Método para la subclasificación de tumores.

Método para la subclasificación de tumores.

La presente invención proporciona un método de subclasificación o pronóstico de tumores

, preferiblemente de mama, más preferiblemente positivos para los receptores hormonales de estrógenos, basado en la cuantificación de una serie de biomarcadores que se han identificado como diferencialmente expresados entre pacientes con mejor y peor pronóstico de la enfermedad. Dicho método permite determinar el riesgo de recaída y/o metástasis, siendo por tanto una herramienta útil para valorar el tratamiento más adecuado a administrar al paciente. Además, la presente invención se refiere a un kit que permite la subclasificación o pronóstico de tumores mediante este método.

Tipo: Patente de Invención. Resumen de patente/invención. Número de Solicitud: P201430887.

Solicitante: FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (FIBHULP).

Nacionalidad solicitante: España.

Inventor/es: FRESNO VARA,JUAN ANGEL, GAMEZ-POZO,ANGELO, ESPINOSA ARRANZ,Enrique, BERGES SORIA,Julia, LÓPEZ VACAS,Rocío.

Fecha de Publicación: .

Clasificación Internacional de Patentes:

  • SECCION G — FISICA > METROLOGIA; ENSAYOS > INVESTIGACION O ANALISIS DE MATERIALES POR DETERMINACION... > G01N33/00 (Investigación o análisis de materiales por métodos específicos no cubiertos por los grupos G01N 1/00 - G01N 31/00)
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Opinión escrita:

Fecha de Realización de la Opinión Escrita: 02.11.2015

Declaración
Novedad (Art. 6.1 LP 11/1986) Reivindicaciones 1-11
Reivindicaciones NO
Actividad inventiva (Art. 8.1 LP 11/1986) Reivindicaciones
Reivindicaciones1-11 NO


Se considera que la solicitud cumple con el requisito de aplicación industrial. Este requisito fue evaluado durante la fase de examen formal y técnico de la solicitud (Artículo 31.2 Ley 11/1986) .

Base de la Opinión.-

La presente opinión se ha realizado sobre la base de la solicitud de patente tal y como se publica.

1. Documentos considerados.-

A continuación se relacionan los documentos pertenecientes al estado de la técnica tomados en consideración para la realización de esta opinión.

Documento Número Publicación o Identificación Fecha Publicación
D01 WO 8502684 A1 (CHILDRENS HOSP MEDICAL CENTER) 20.06.1985
D02 PAWLAK J et al. Evaluation of thioesterase II as a serum marker for rat mammary cancer. Cancer research. UNITED STATES. Sep. 1986. Vol. 46. Nº. 9. Páginas 4712-4719. ISSN 0008-5472 (Print)

2. Declaración motivada según los artículos 29.6 y 29.7 del Reglamento de ejecución de la Ley 11/1986, de 20 de marzo, de Patentes sobre la novedad y la actividad inventiva; citas y explicaciones en apoyo de esta declaración

La presente solicitud divulga un método para el pronóstico in vitro de un sujeto que presenta un tumor mediante la identificación y cuantificación del producto de expresión del gen THEM6. En concreto el tumor es un tumor de mama. La reivindicación 1 caracteriza el método por consistir en la cuantificación y comparación de la cantidad medida con un valor de referencia, que se obtiene por comparación de la cantidad cuantificada en la muestra problema con la cuantificación del producto de expresión del gen en una muestra de células tumorales de un individuo que presenta un tumor triple negativo ( reivindicación 4) , siendo indicativo de un mal pronóstico el que la cantidad del producto de expresión en la muestra objeto de análisis no presente desviación significativa con respecto al valor de referencia (reivindicaciones 5 y 6) .

D01 divulga un método para detectar la enzima tioesterasa II en muestras de tejido y suero. La presencia de tioesterasa IIse asocia con la existencia de células epiteliales mamarias neoplásicas (reivindicaciones 1-11) . Él método es útil para la detección de células epiteliales mamarias, y es particularmente útil para la detección de células epiteliales mamarias neoplásicas que han metastatizado de un tumor de mama primario. Así pues, la presencia de la enzima tioesterasa II en el suero es indicativo de tumores epiteliales mamarias primarios o metastásicos.

D02 divulga la especificidad que tiene el marcador THEM2 con respecto al tejido mamario, en un modelo murino de cáncer de mama. También asocia cambios en el nivel sérico del enzima con el estado fisiológico o patológico de la glándula mamaria. Además THEM2 es indetectable en muestras séricas de individuos no cancerosos, y el nivel de expresión de tal marcador es particularmente alto en aquellos tumores que conservan una morfología epitelial.

Ninguno de los documentos del estado de la técnica divulga un método para el pronóstico del cáncer de mama que haga uso de la identificación de los niveles de expresión THEM6, por lo que las reivindicaciones 1-11 cumplirían con el requisito de novedad tal y como se menciona en el art. 6 de la ley 11-1986.

Tomando en consideración D01 como el estado de la técnica más cercano al objeto de la invención, la diferencia entre ambos sería la identificación de THEM6. El efecto técnico producto de esta diferencia sería la elaboración de un nuevo método para pronosticar la gravedad del cáncer de mama. Por tanto el problema que resuelve la presente invención sería la provisión de un nuevo panel de marcadores para el pronóstico del cáncer de mama. El experto en la materia conocedor de las excepcionales condiciones de THEM2 tanto en su especificidad de tejido, como en su capacidad de información respeto al cáncer de mama, se sentiría inclinado a buscar otras isomorfas de la familia de las tioesterasas para ser utilizadas en la elaboración otro método con capacidad para pronosticar in vitro la gravedad del cáncer de mama, teniendo a priori muchas probabilidades de éxito. Así pues, la identificación de THEM6 como marcador pronóstico de cáncer de mama y la elaboración de un método para su uso equivaldría a una selección alternativa a la de THEM2, por lo que las reivindicaciones 1-11 no cumplirían con el requisito de actividad inventiva tal y como se menciona en al art. 8 de la ley 11/1986.


 


Informe sobre el Estado de la Técnica:

Clasificación:
G01N33/00 (2006.01)

El presente informe ha sido realizado para las siguientes reivindicaciones: TODAS
Fecha de realización del informe: 02.11.2015
Examinador: J. Manso Tomico

CategoríaDocumentos citadosReivindicaciones afectadas
X WO 8502684 A1 (CHILDRENS HOSP MEDICAL CENTER) 20.06.1985, reivindicaciones. 1-11
X PAWLAK J et al. Evaluation of thioesterase II as a serum marker for rat mammary cancer. Cancer research. UNITED STATES. Sep. 1986. Vol. 46. Nº. 9. Páginas 4712-4719. ISSN 0008-5472 (Print). 1-11


Categoría de los documentos citados
X: de particular relevancia O: referido a divulgación no escrita
Y: de particular relevancia combinado con otro/s de la misma categoría P: publicado entre la fecha de prioridad y la de presentación de la solicitud
A: refleja el estado de la técnica E: documento anterior, pero publicado después de la fecha de presentación de la solicitud

Documentación mínima buscada (sistema de clasificación seguido de los símbolos de clasificación)

G01N

Bases de datos electrónicas consultadas durante la búsqueda (nombre de la base de datos y, si es posible, términos de búsqueda utilizados)

INVENES, EPODOC, WPI, EMBASE, BIOSIS.


 


Texto extraído del PDF original:

MÉTODO PARA LA SUBCLASIFICACIÓN DE TUMORES

DESCRIPCIÓN

La presente invención se encuadra dentro del campo de la biología molecular y la oncología, específicamente, dentro de los métodos de subclasificación de tumores, preferiblemente de mama. Concretamente, se refiere a un método de pronóstico de la evolución de los tumores, el cual permite determinar el riesgo de recaída y/o metástasis, siendo por tanto una herramienta útil para determinar el tratamiento más adecuado a administrar al paciente. Además, la presente invención se refiere a un kit que permite la subclasificación de tumores mediante este método.

ESTADO DE LA TÉCNICA

El cáncer de mama es el tumor maligno más frecuente en las mujeres y la primera causa de muerte por cáncer en éstas. Es una enfermedad heterogénea en cuanto a las manifestaciones clínicas, el pronóstico y la sensibilidad a los diferentes tratamientos médicos. El pronóstico del cáncer de mama es particularmente relevante, ya que sirve para seleccionar los tratamientos más adecuados que la paciente recibirá, por ejemplo, terapia adyuvante después de la cirugía para reducir el riesgo de recaída.

No todas las pacientes se beneficiarán de una terapia adyuvante. Así, por ejemplo, en pacientes que presentan un buen pronóstico tras un primer tratamiento es menos probable que la enfermedad recurra, y así es menos probable que estas pacientes obtengan un beneficio adicional por parte de terapias adyuvantes sistémicas, pudiendo evitarse dicho tratamiento en estos casos. Además, la respuesta a un determinado tipo de terapia adyuvante puede variar entre las pacientes que están siendo sometidas a la misma. Es por tanto de crucial importancia identificar factores asociados al pronóstico, los cuales permitan determinar la agresividad del tumor y sean útiles para estimar la progresión de la enfermedad. El análisis de dichos factores permitirá adecuar el tratamiento terapéutico a cada caso clínico y además predecir la sensibilidad o resistencia de un tumor a un determinado agente terapéutico. Estos factores, por tanto, permitirán determinar el pronóstico del cáncer de mama siendo de utilidad para evaluar si la paciente se beneficiará de una terapia adyuvante y qué tipo de terapia será la más adecuada en su caso.

En los últimos años numerosas publicaciones han puesto de manifiesto que las nuevas técnicas de alto rendimiento en genómica pueden ser de gran utilidad en la consecución de estos objetivos (Marchionni et al. Evid Rep Technol Assess. 2007 Dec.;(160):1-105). Estas técnicas pueden proporcionar información sobre el riesgo de padecer la enfermedad, la presencia de un tumor oculto en programas de detección precoz, la detección precoz de una recaída, la posibilidad de que aparezca dicha recaída del cáncer (pronóstico) y la posibilidad de sufrir efectos secundarios y de respuesta a los tratamientos. Así, se han divulgado varios perfiles genéticos relacionados con el pronóstico en cáncer de mama. Tres de estos perfiles, los conocidos como “70-gene Signature” (van 't Veer et al. Nature. 2002 Jan 31;415(6871):530-6), “Recurrence Score” (Paik et al. N Engl J Med. 2004 Dec 30;351(27):2817-26), y “H/I Index” (Ma et al. J Clin Oncol. 2006 Oct 1;24(28):4611-9), han pasado una validación independiente, lo que se podría llamar ensayos en fase II.

El perfil de genes con valor pronóstico “70-gene Signature”, comercializado con el nombre de MammaPrint® por la empresa Agendia, se ofrece para el diagnóstico de pacientes que presenten los siguientes criterios: tamaño del tumor menor de 5 cm, carcinoma de mama en estadio I o II, sin afectación ganglionar o hasta 3 ganglios linfáticos afectos, independientemente de la expresión del receptor de estrógenos (ER). El procedimiento requiere la medida de la expresión de los 70 genes que determinan la firma génica asociada a pronóstico. El método empleado para su desarrollo consistió en la obtención de RNA a partir de tejido congelado en fresco (FF, siglas del inglés “Fresh Frozen”) y el empleo de microarrays de cDNA. El uso de tejido congelado para estudios moleculares a gran escala presenta varios problemas: las muestras congeladas son difíciles de recoger, complicadas de procesar y costosas de almacenar. Por el contrario, las muestras de tejido fijadas en formol y embebidas en parafina (FFPE, siglas del inglés “Formalin-Fixed Paraffin-Embedded”) son estables a temperatura ambiente, fáciles de almacenar y, lo que es más importante, existe un amplio archivo de muestras clínicas disponibles junto con su información clínica y el seguimiento de la enfermedad. Actualmente este método se ofrece también en muestras FFPE. Por otro lado, el análisis de expresión mediante microarrays es una técnica compleja que requiere de equipos sofisticados.

En los otros dos perfiles genéticos con valor pronóstico mencionados anteriormente, conocidos como “Recurrence Score” y “H/I Index”, el método empleado consiste en la obtención de RNA a partir de muestras de tumores FFPE y el empleo de la técnica RT-PCR a tiempo real, con las ventajas que ello supone.

El perfil “H/I Index” comercializado con el nombre de Theros H/I™ por la empresa BioTheranostics, requiere la medida de la expresión de los genes HOXB13 e IL17BR que determinan la firma génica asociada a pronóstico y 4 genes que permiten la normalización. Este método permite pronosticar la respuesta al tratamiento hormonal en mujeres con carcinoma de mama positivo para la expresión del receptor de estrógenos y sin ganglios afectos.

El perfil “Recurrence Score”, comercializado con el nombre de Oncotype DX™ por la empresa Genomic Health, Inc., se ofrece para el pronóstico de pacientes a las que se les ha diagnosticado un carcinoma de mama invasivo en estadio I o II positivo para la expresión del receptor de estrógenos y que no presentan afectación de los ganglios linfáticos. Este perfil es uno de los pocos para los que se han realizado estudios que permiten afirmar su utilidad clínica para predecir el beneficio de un tratamiento quimioterapéutico (Gianni et al. J Clin Oncol. 2005;23(29):7265-7277; Paik et al. J Clin Oncol. 2006;24(23):3726-3724; Chang et al. Breast Cancer Res Treat. 2008 Mar;108(2):233-40).

Por otro lado, otro de los perfiles génicos propuestos para el pronóstico o subclasificación de tumores de mama es el llamado “8-gene Score” (WO2010066928, Sánchez-Navarro et al. BMC Cancer 2010, 10:336), el cual se basa en la cuantificación de ocho genes relacionados con la proliferación celular, específicamente de los genes DTL, ECT2, MTDH, PRC1, RFC4, SCUBE2, STK32B y ZNF533.

Otro de los perfiles génicos propuestos para el pronóstico o subclasificación de tumores de mama es el llamado PAM50 (Prosigna), basado en la expresión de 50 genes (además de 5 genes control), permite la identificación de los subtipos intrínsecos moleculares (LumA, LumB, Her2 y Basal) y la estimación del riesgo individual de recurrencia distante en pacientes ER+ (Jorgensen CL, Nielsen TO, Bjerre KD, Liu S, Wallden B, Balslev E, et al. PAM50 breast cancer intrinsic subtypes and effect of gemcitabine in advanced breast cancer patients. Acta Oncol. 2013). También proporciona valores cuantitativos para la proliferación y la expresión de los genes

ESR1, PGR y ERBB2. Los 50 genes son específicamente elegidos por su capacidad de ser analizados desde tejidos tumorales parafinados o frescos, y mediante dos plataformas: RT-qPCR o Nanostring.

En conclusión, el cáncer, y concretamente el cáncer de mama, es una enfermedad heterogénea con diferentes subtipos tumorales que presentan distinto pronóstico y respuesta a las diferentes opciones terapéuticas. Durante los últimos años se ha puesto de manifiesto que las técnicas de alto rendimiento en genómica son de gran utilidad para pronosticar el riesgo de recaída, de metástasis, la supervivencia y la respuesta a los diferentes tratamientos médicos adyuvantes. Sin embargo, los perfiles génicos descritos hasta la fecha para el pronóstico del cáncer requieren aún de ensayos de validación. Por otra parte, la capacidad predictiva de cada perfil es bastante limitada y existe la necesidad de disponer de perfiles génicos que proporcionen información complementaria a los ya existentes y que permitan pronosticar de forma fiable y eficiente la evolución del tumor, especialmente en términos de recurrencia y/o metástasis, así como la respuesta a las terapias administradas, sirviendo así de ayuda en la toma de decisiones terapéuticas.

DESCRIPCIÓN DE LA INVENCIÓN

La presente invención proporciona un método de subclasificación de tumores, preferiblemente de mama, basado en la cuantificación de una serie de biomarcadores que se han identificado como diferencialmente expresados entre pacientes con mejor y peor pronóstico de la enfermedad. Concretamente, se refiere a un método de pronóstico de tumores, preferiblemente de mama, el cual permite determinar el riesgo de recaída y/o metástasis, siendo por tanto una herramienta útil para valorar el tratamiento más adecuado a administrar al paciente. Además, la presente invención se refiere a un kit que permite la subclasificación o pronóstico de tumores mediante este método.

El método de la presente invención permite identificar pacientes con alto riesgo de metástasis y/o recurrencia en cáncer, preferiblemente de mama, siendo la información pronóstica que proporciona independiente y complementaria a la que proporcionan los perfiles genéticos comerciales (Mammaprint, Oncotype, y 8-gene Score). Estos perfiles comerciales están basados en genes relacionados con la proliferación celular, sin embargo, el método de la invención emplea genes o proteínas (biomarcadores) relacionados con otro proceso biológico, la adhesión celular, íntimamente relacionado con la metástasis. El uso de la proteómica de alto rendimiento ha permitido a los inventores identificar este proceso como desregulado en una población de pacientes de cáncer de mama con positividad para los receptores hormonales de estrógeno (ER+), siendo ésta una característica propia de tumores de mama triple negativo (TNBC) los cuales son más agresivos y presentan un peor pronóstico. Por tanto, el método de la invención permite pronosticar la evolución del tumor en términos de metástasis y/o recurrencia, identificando (subclasificando) dentro de los pacientes de cáncer, preferiblemente de mama, más preferiblemente cáncer de mama ER+, una población con altas probabilidades de sufrir metástasis/recaída a pesar de ser pacientes que han podido ser previamente clasificadas de bajo riesgo por los perfiles comerciales actuales.

El método de la invención permite además decidir si es posible evitar la terapia adyuvante (quimioterapia) en pacientes de cáncer, preferiblemente de mama, con riesgo de recurrencia bajo o intermedio en los que no está clara la decisión terapéutica, permitiendo asimismo el uso de terapias dirigidas y personalizadas.

Por ello, un primer aspecto de la invención se refiere a un método para el pronóstico in

vitro de un sujeto que presenta un tumor, que comprende: a. Cuantificar, en una muestra biológica aislada que comprende células tumorales de dicho sujeto, la cantidad del producto de la expresión del gen THEM6 (SEQ ID NO: 1), y b. Comparar la cantidad cuantificada en la etapa (a) con un valor de referencia.

A dicho método se hará referencia en la presente invención como “método de la invención”.

En una realización preferida, el método de la invención además comprende en la etapa (a) la cuantificación de la cantidad del producto de la expresión del gen COLGALT1 (SEQ ID NO: 2).

En una realización más preferida, el método de la invención además comprende en la etapa (a) la cuantificación de la cantidad del producto de expresión de al menos uno de los genes seleccionados de la lista que consiste en: APCS (SEQ ID NO: 3), AZGP1 (SEQ ID NO: 4), ASPN (SEQ ID NO: 5), CAPRIN1 (SEQ ID NO: 6), CTSG (SEQ ID NO: 7), CPA3 (SEQ ID NO: 8), CCDC40 (SEQ ID NO: 9), CMA1 (SEQ ID NO: 10), NCAPG2 (SEQ ID NO: 11), COL1A1 (SEQ ID NO: 12), COL6A1 (SEQ ID NO: 13), COL6A2 (SEQ ID NO: 14), COL6A3 (SEQ ID NO: 15), COL14A1 (SEQ ID NO: 16), EEF2 (SEQ ID NO: 17), EIF2A (SEQ ID NO: 18), FMOD (SEQ ID NO: 19), HSP90AB1 (SEQ ID NO: 20), HSPB6 (SEQ ID NO: 21), LUM (SEQ ID NO: 22), OGN (SEQ ID NO: 23), NSUN2 (SEQ ID NO: 24), BGN (SEQ ID NO: 25), DCN (SEQ ID NO: 26), PIP (SEQ ID NO: 27), PRKCDBP (SEQ ID NO: 28), PRELP (SEQ ID NO: 29), PSMC2 (SEQ ID NO: 30), RAB10 (SEQ ID NO: 31), SF3A1 (SEQ ID NO: 32), SOD3 (SEQ ID NO: 33), SRRM2 (SEQ ID NO: 34), STIP1 (SEQ ID NO: 35) o CCT7 (SEQ ID NO: 36), o cualquiera de sus combinaciones.

En una realización aún más preferida, el método de la invención comprende en la etapa (a) la cuantificación de la cantidad del producto de expresión de los genes THEM6, COLGALT1, APCS, AZGP1, ASPN, CAPRIN1, CTSG, CPA3, CCDC40, CMA1, NCAPG2, COL1A1, COL6A1, COL6A2, COL6A3, COL14A1, EEF2, EIF2A, FMOD, HSP90AB1, HSPB6, LUM, OGN, NSUN2, BGN, DCN, PIP, PRKCDBP, PRELP, PSMC2, RAB10, SF3A1, SOD3, SRRM2, STIP1 y CCT7.

Dentro del alance de la presente invención se incluyen también aquellos genes que co-expresan o se encuentran correlacionados con los genes indicados anteriormente.

Un ejemplo de dichos genes que co-expresan con éstos, y cuya cuantificación sería por tanto también un valor útil para el método de pronóstico aquí descrito, son los que se detallan en la Fig. 8.

El término “muestra biológica aislada que comprende células tumorales”, tal y como se utiliza en la descripción se refiere, pero no se limita, a tejidos y/o fluidos biológicos de un sujeto, obtenidos mediante cualquier método conocido por un experto en la materia que sirva para tal fin. La muestra biológica puede ser un tejido, por ejemplo, pero sin limitarse, una biopsia tumoral o un aspirado por aguja fina, o puede ser un fluido biológico, por ejemplo, pero sin limitarse, una muestra de fluido, como sangre, plasma, suero, linfa, fluido ascítico, orina o exudado mamario. La muestra puede ser tomada de un mamífero humano, pero también de mamíferos no humanos, como por ejemplo, pero sin limitarse roedores, rumiantes, felinos o cánidos. La muestra biológica puede ser fresca, congelada, fijada o embebida en parafina. Preferiblemente, la muestra está fijada en formalina y embebida en parafina. Más preferiblemente, el sujeto del que se obtiene la muestra biológica aislada es un humano.

Aún más preferiblemente, la muestra biológica se aísla de un sujeto que ha estado previamente sometido a una terapia antitumoral, incluyendo quimio y/o radioterapia, una mastectomía, o bien a una cirugía conservadora seguida de radio o quimioterapia.

El método de la presente invención es útil para predecir la respuesta del cáncer a un determinado tratamiento. En otra realización preferida, el método de la presente invención es útil para tomar decisiones con respecto al tratamiento adyuvante a un tratamiento principal administrado al paciente. En una realización alternativa, el método de la presente invención es útil para tomar decisiones con respecto al tratamiento neoadyuvante a un tratamiento principal administrado al paciente.

Los términos “tumor” o “tumoral”, tal y como se utilizan en la presente descripción, se refieren a células transformadas que presentan un crecimiento incontrolado.

Dependiendo de su posible evolución puede tratarse de un tumor benigno, que permanece en su lugar de inicio y no produce metástasis, o de un tumor maligno o cáncer, invasivo o que puede producir metástasis. El término “tumor” se refiere en la presente invención tanto a un tumor benigno como maligno.

El término “cáncer” o “canceroso” tal y como se utiliza en la presente descripción, se refiere a un tumor maligno, es decir, a una alteración de las células tumorales que tienen capacidad de invadir tejidos o de producir metástasis en lugares distantes del tumor primario. El término “cáncer”, tal y como se utiliza en la presente descripción, se refiere por tanto a la enfermedad neoplásica en la cual las células, de morfología anormal, presentan un crecimiento descontrolado llegando a generar un tumor maligno. Se entiende por “cáncer” el conjunto de enfermedades en las cuales el organismo produce un exceso de células malignas (células cancerosas), con crecimiento descontrolado y división más allá de los límites normales, que en estadios avanzados conduce a la invasión del tejido circundante y, finalmente, a metástasis.

Comprende cualquier enfermedad de un órgano o tejido en un mamífero, preferiblemente el hombre, caracterizada por una multiplicación pobremente controlada, o descontrolada, de células normales o anormales en dicho tejido, y su efecto en la totalidad del cuerpo.

El término “cáncer”, dentro de esta definición, incluye las neoplasias malignas (como carcinoma, sarcoma, carcinosarcoma, etc.), displasias, hiperplasias, así como neoplasias que muestran metástasis, o cualquier otra transformación como por ejemplo, leucoplasias que a menudo preceden al brote del cáncer. Las células y los tejidos son cancerosos cuando crecen y se replican más rápidamente de lo normal, desplazándose o dispersándose en el tejido sano circundante o en cualquier otro tejido del cuerpo, lo que se conoce como metástasis, asume formas y tamaños anormales, muestra cambios en su ratio nucleocitoplasmático, policromasia nuclear, y finalmente cesa. Células y tejidos cancerosos pueden afectar al cuerpo como un todo causando síndromes paraneoplásicos, o pueden ocurrir en un órgano o tejido vital, siendo interrumpida o dañada su función normal, con posibles resultados fatales.

Generalmente se dice que el cáncer se encuentra en uno de tres estados de crecimiento: temprano o localizado, cuando el tumor aún se encuentra confinado en el tejido de origen, o en su localización primaria; extensión directa, cuando las células cancerosas del tumor han invadido el tejido adyacente o se ha extendido únicamente a los nódulos linfáticos regionales; o metástasis, cuando las células cancerosas han migrado a partes distantes del cuerpo desde la localización primaria, por medio del sistema circulatorio o linfático, y se ha establecido en localizaciones secundarias.

Ejemplos de tipos de cáncer son, aunque sin limitarnos, cánceres ginecológicos, cáncer de colon, cáncer de próstata, cáncer de piel incluyendo melanoma, cáncer hepático, cáncer de pulmón, cáncer de esófago, cáncer gástrico, cáncer de páncreas, cáncer de vejiga, cáncer del tracto urinario, cáncer tiroideo, cáncer renal, cáncer de cerebro, sarcoma, linfoma o leucemia. Existe un grupo de tumores en los que es importante la participación de la regulación hormonal, tales como los tumores de mama, ginecológicos o de próstata. Dentro de los cánceres ginecológicos se engloban los tumores de mama, ovario, útero, cérvix, vagina y vulva. El método de la invención es extrapolable a estos otros tipos de tumores de origen hormonal además del de mama. Por tanto, preferiblemente, el método de la presente invención se refiere, pero no se limita a un método para la subclasificación o pronóstico in vitro de tumores de origen hormonal, más preferiblemente de mama, ginecológicos o de próstata.

En una realización más preferida del método de la invención, el tumor es de mama.

El “tumor de mama” es la proliferación acelerada, desordenada y no controlada de células pertenecientes a distintos tejidos de una glándula mamaria. La palabra “carcinoma” se aplica a los tumores malignos que se originan en estirpes celulares de origen epitelial o glandular. La mayoría de los carcinomas de mama tienen su origen en la proliferación acelerada e incontrolada de las células que tapizan el interior de los conductos que durante la lactancia llevan la leche desde los acinos glandulares, donde se produce, hasta los conductos galactóforos, situados detrás de la areola y el pezón, donde se acumula en espera de salir al exterior; este cáncer de mama se conoce como “carcinoma ductal”. En los casos restantes el cáncer tiene su origen en los propios acinos glandulares y se le llama “carcinoma lobulillar”.

Muchos carcinomas de mama se encuentran confinados en la luz de los ductos o de los acinos, sin invadir los tejidos vecinos, recibiendo el nombre de “carcinomas in situ”.

Cuando proliferan en demasía pueden romper la llamada membrana basal y extenderse infiltrando los tejidos que rodean a ductos y acinos y entonces reciben nombres como “carcinoma ductal infiltrante” o “carcinoma lobulillar infiltrante”.

En la presente invención el término “tumor de mama” incluye a los carcinomas de mama en cualquiera de los cinco estadios posibles (0, I, II, III y IV). El tumor se clasifica en estos estadios en función del tamaño del tumor (T), la diseminación a los ganglios linfáticos (N), y la metástasis o diseminación a otras partes del cuerpo (M).

Las expresiones “sin afectación de los ganglios linfáticos”, “sin ganglios linfáticos afectos”, tal y como se utiliza en la presente descripción, se refiere a un cáncer que no se ha diseminado a los ganglios linfáticos. Por el contrario, el término “con afectación de los ganglios linfáticos” o “con ganglios linfáticos afectos”, tal y como se utiliza en la presente descripción, se refiere a un cáncer que se ha diseminado a al menos a un ganglio linfático.

Como se muestra posteriormente en los ejemplos de la presente invención, mediante el método aquí descrito los inventores fueron capaces de identificar, dentro de un grupo de pacientes de cáncer de mama previamente diagnosticadas clínicamente como pacientes de cáncer de mama positivo para la expresión de los receptores hormonales de estrógenos (ER+), una subpoblación cuyo perfil de expresión en base a la firma proteica aquí propuesta tenía una mayor similitud con un grupo de pacientes de cáncer de mama triple negativo (TNBC). Esta subpoblación ER+ cuya firma génica era similar a la del grupo TNBC presentaba una supervivencia libre de metástasis inferior (71,1%) a la de pacientes con cáncer ER+-real (88%). De modo que dicha subpoblación de pacientes ER+ con tumores con características TNBC no solo tenía un perfil molecular más parecido al de estos últimos, sino que además la evolución clínica de estas pacientes era parecida a la de aquellas con TNBC, siendo los grupos con peor pronóstico.

Así, el método de la invención es de utilidad para subclasificar pacientes diagnosticadas como cáncer de mama ER+ en pacientes con cáncer de mama con características de TNBC con un peor pronóstico.

Por ello, más preferiblemente en el método de la invención el tumor es un tumor de mama HER2 negativo o positivo para la expresión de los receptores hormonales de estrógenos (ER+).

La expresión “positivo para receptores hormonales”, tal y como se utiliza en la presente descripción, se refiere a un tumor que presenta expresión para el receptor de estrógenos y/o progesterona. Se entiende por “cáncer de mama positivo para los receptores hormonales de estrógenos (ER+)” un tumor que presenta expresión para el receptor de estrógenos. La expresión “positivo para receptor de progesterona” se refiere a un tumor que presenta expresión para el receptor de progesterona. Como se ha indicado en el párrafo anterior, preferiblemente, el método de la presente invención se refiere, pero no se limita, a un método para la subclasificación o pronóstico de tumores de mama positivos para la expresión del receptor de estrógenos.

El “cáncer de mama triple negativo (TNBC)” se define como la ausencia de tinción en el receptor de estrógeno, en el receptor de progesterona y HER2/neu. Suele ser más agresivo que otros tipos de cáncer de mama, ya que al no estar estimulado el crecimiento del tumor por las hormonas estrógeno y progesterona, ni por la presencia de demasiados receptores de HER2, este tipo de cáncer no responde a la hormonoterapia (como tamoxifeno o inhibidores de la aromatasa) ni a las terapias dirigidas a los receptores de HER2, como Herceptin (nombre genérico: trastuzumab).

El término “producto de la expresión”, tal y como se utiliza en esta descripción, hace referencia a cualquier producto de transcripción o expresión (ARN o proteína) de los genes propuestos en el método de la invención, o a cualquier forma resultante del procesamiento de dichos productos de transcripción o expresión. Los productos de expresión de los genes descritos en la presente invención son, preferiblemente, mRNA o proteína.

El término “cantidad”, tal y como se utiliza en la descripción, se refiere pero no se limita, a la cantidad absoluta o relativa del producto de expresión del gen, así como a cualquier otro valor o parámetro relacionado con la misma o que pueda derivarse de ésta. Dichos valores o parámetros comprenden valores de intensidad de la señal obtenidos a partir de cualquiera de las propiedades físicas o químicas de los productos de expresión de los genes especificados, obtenidos mediante medida directa, por ejemplo, valores de intensidad de espectrometría de masas o resonancia magnética nuclear. Adicionalmente, dichos valores o parámetros incluyen todos aquellos obtenidos mediante medida indirecta, por ejemplo, cualquiera de los sistemas de medida descritos posteriormente.

La cuantificación de la cantidad de producto de la expresión de los genes en la muestra obtenida, tal y como se utiliza en la descripción, hace referencia a la medida de la cantidad o la concentración, preferiblemente de manera semi-cuantitativa o cuantitativa. La medida puede ser llevada a cabo, como se ha indicado anteriormente, de manera directa o indirecta. La medida directa se refiere a la medida de la cantidad o la concentración del producto de la expresión del gen basada en una señal que se obtiene directamente del producto de la expresión del gen y que está correlacionada directamente con el número de moléculas del producto de la expresión del gen presente en la muestra. Dicha señal – a la que también podemos referirnos como señal de intensidad – puede obtenerse, por ejemplo, midiendo un valor de intensidad de una propiedad química o física del producto de expresión. La medida indirecta incluye la medida obtenida de un componente secundario (por ejemplo, un componente distinto del producto de la expresión génica) o un sistema de medida biológica (por ejemplo la medida de respuestas celulares, ligandos, “etiquetas” o productos de reacción enzimática).

De acuerdo con la presente invención, la cuantificación de la cantidad de producto de la expresión de los genes puede ser llevada a cabo por cualquier método de determinación de la cantidad del producto de la expresión de los genes conocido por el experto en la materia. En una realización preferida, la cuantificación del producto de la expresión de los genes se realiza determinando el nivel de mRNA derivado de su transcripción, donde el análisis del nivel de mRNA se puede realizar, a título ilustrativo y sin que limite el alcance de la invención, mediante amplificación por reacción en cadena de la polimerasa (PCR), retrotranscripción en combinación con la reacción en cadena de la ligasa (RT-LCR), retrotranscripción en combinación con la reacción en cadena de la polimerasa (RT-PCR), retrotranscripción en combinación con la reacción en cadena de la polimerasa cuantitativa (qRT-PCR), o cualquier otro método de amplificación de ácidos nucleicos; microarrays de DNA elaborados con oligonucleótidos depositados por cualquier mecanismo; microarrays de DNA elaborados con oligonucleótidos sintetizados in situ mediante fotolitografía o por cualquier otro mecanismo; hibridación in situ utilizando sondas específicas marcadas con cualquier método de marcaje; mediante geles de electroforesis; mediante transferencia a membrana e hibridación con una sonda específica; mediante RMN o cualquier otra técnica de diagnóstico por imagen utilizando nanopartículas paramagnéticas o cualquier otro tipo de nanopartículas detectables funcionalizadas con anticuerpos o por cualquier otro medio.

El mRNA puede ser extraído, por ejemplo, pero sin limitarse a partir de muestras de tejido fresco, tejido FF o de muestras de tejido FFPE. Los métodos de obtención de RNA total o mRNA son bien conocidos en el estado de la técnica. El uso de muestras de tejido FFPE presenta importantes ventajas con respecto a las muestras de tejido FF: son estables a temperatura ambiente, fáciles de almacenar y existe un amplio archivo de muestras clínicas disponibles junto con su información clínica y el seguimiento de la enfermedad. Por tanto, en una realización preferida el mRNA se extrae de muestras de tejido FFPE.

En otra realización preferida, la cuantificación de la cantidad de producto de expresión de los genes en la muestra biológica se realiza determinando el nivel de las proteínas codificadas por dichos genes, mediante preferiblemente la incubación con un anticuerpo específico, en ensayos como Western blot, geles de electroforesis, inmunoprecipitación, arrays de proteína, inmunofluorescencia, inmunohistoquímica, ELISA o cualquier otro método enzimático; mediante la incubación con un ligando específico; mediante RMN o cualquier otra técnica de diagnóstico por imagen; o, por ejemplo, mediante técnicas cromatográficas combinadas con espectrometría de masas.

La cuantificación de la proteína de interés puede llevarse a cabo por medio de cualquiera de las técnicas mencionadas o por cualquier combinación de las mismas.

La proteína puede ser detectada evaluando su presencia o ausencia. La detección puede llevarse a cabo por medio del reconocimiento específico de cualquier fragmento de la proteína por medio de cualquier sonda y/o cualquier anticuerpo. La proteína, o cualquiera de sus fragmentos, puede ser cuantificada, sirviendo estos datos como referencia para compararlos con el valor de referencia y buscar alguna desviación significativa. Esta desviación significativa puede ser asignada al pronóstico de cáncer en el individuo del que procede la muestra problema. En una realización preferida, la proteína, o cualquiera de sus fragmentos, puede ser cuantificada por medio de electroforesis y/o inmunoensayo.

La “electroforesis” es una técnica analítica de separación basada en el movimiento o la migración de macro-moléculas disueltas en un medio (buffer de electroforesis), mediante una matriz o un sólido apoyo como resultado de la acción de un campo eléctrico. El comportamiento de la molécula depende de su movilidad electroforética y esta movilidad depende de la carga, tamaño y forma. Existen numerosas variaciones de esta técnica basadas en el equipamiento usado, soportes y condiciones para llevar a cabo la separación de las proteínas. La electroforesis se selecciona de la lista que comprende, pero sin limitarse, electroforesis capilar, electroforesis en papel, electroforesis en gel de agarosa, electroforesis en gel de poliacrilamida, isoelectroenfoque o electroforesis bidimensional.

Un “inmunoensayo” es una prueba bioquímica que mide la concentración de una sustancia en un líquido biológico usando la reacción de un anticuerpo o anticuerpos con alguno de sus antígenos. El ensayo aprovecha la especificidad de un anticuerpo con su antígeno. La cantidad de anticuerpo o antígeno puede detectarse por medio de métodos conocidos en el estado de la técnica. Uno de los métodos más comunes es el que se basa en el marcaje del antígeno o de los anticuerpos. El marcaje puede llevarse a cabo, pero sin limitarse, mediante una enzima, radioisótopos (radioinmunoensayo), etiquetas magnéticas (inmunoensayo magnético) o fluorescencia, y también otras técnicas incluidas aglutinación, nefelometría, turbidimetría o Western Blot. Los inmunoensayos heterogéneos pueden ser competitivos o no competitivos. El inmunoensayo puede ser competitivo: la respuesta será inversamente proporcional a la concentración de antígeno en la muestra, o puede ser no competitivo (conocido también como "sandwich assay"): los resultados son directamente proporcionales a la concentración del antígeno. Una técnica de inmunoensayo que puede ser utilizada en la presente invención es el ensayo ELISA (Enzyme-Linked ImmunoSorbent Assay).

Por medio de las “técnicas cromatográficas”, las moléculas pueden ser separadas, pero sin limitarse, por su carga, tamaño, masa molecular, mediante su polaridad o mediante su potencial redox. La técnica de cromatografía se selecciona, pero sin limitarse, de entre cromatografía de líquidos (cromatografía de partición, cromatografía de adsorción, cromatografía de exclusión o cromatografía de intercambio iónico), cromatografía de gases o cromatografía de fluidos supercríticos.

La “tecnología de microarray” está basada, por ejemplo, sobre la fijación en un soporte sólido de una molécula que reconoce la proteína de interés. El microarray basado en anticuerpos es el microarray de proteínas más común. En este caso, los anticuerpos se fijan en el soporte sólido (también se puede emplear el término chip para referirse a microarray). Estos anticuerpos son utilizados para capturar moléculas que permiten la detección de proteínas procedentes de muestras biológicas. El término "soporte sólido" tal como se emplea en la presente invención se refiere a una gran variedad de materiales, por ejemplo, pero sin limitarse, intercambio de iones o resina adsorción, vidrio, plástico, látex, nylon, gel, ésteres de celulosa, esferas paramagnéticas o la combinación de algunos de ellos.

El término “valor de referencia” o “punto de corte” o “cantidad de referencia”, tal y como se utiliza en la presente descripción, se refiere a cualquier valor o rango de valores derivado de la cuantificación del producto de la expresión del/los gen/es biomarcador/es en una muestra biológica, o en una colección de muestras biológicas, preferiblemente procedentes de individuos afectados de cáncer con un mal pronóstico, que permita definir dos poblaciones con diferente riesgo de recaída y/o metástasis. La cantidad de referencia se ha de medir de la misma forma, y ser obtenida en el mismo tipo de muestra biológica aislada, que la cantidad medida en el sujeto analizado.

Preferiblemente en el método de la invención, el valor de referencia del paso (b) se obtiene tras la cuantificación del producto de la expresión del gen de la etapa (a) en una muestra biológica aislada que comprende células tumorales de un individuo que presenta un tumor de mama triple negativo.

El término “comparación”, tal y como se utiliza en la descripción, se refiere pero no se limita, a la comparación de la cantidad del producto de expresión del gen cuantificada en la etapa (a) del método de la invención, con un valor de referencia. La comparación descrita en el apartado (b) del método de la presente invención puede ser realizada manualmente o asistida por ordenador.

En una realización más preferida, el método de la invención además comprende un paso (c) donde si la/s cantidad/es cuantificada/s en el paso (a) no presenta/n una desviación significativa con respecto al valor de referencia con el que se compara/n en el paso (b), se asigna al sujeto al grupo de pacientes con un mal pronóstico.

El término “pronóstico”, tal y como se utiliza en la presente descripción, se refiere, pero no se limita, a la determinación de la progresión de un tumor, incluyendo recaída o recurrencia, capacidad de diseminación metastásica, supervivencia libre de metástasis o respuesta a un determinado tratamiento. En una realización más preferida, el “mal pronóstico“ se refiere a un alto riesgo de recaída y/o de metástasis, y/o una menor supervivencia libre de recaída a distancia o de metástasis o una menor supervivencia global.

El término “supervivencia libre de recaída a distancia” (SLRD), tal y como se utiliza en la presente descripción, se refiere al tiempo transcurrido desde la fecha de la cirugía hasta la recaída a distancia o hasta la última visita. El término “supervivencia global” (SG), tal y como se utiliza en la presente descripción, se refiere al tiempo transcurrido desde la fecha de la cirugía hasta la última visita o hasta el fallecimiento del paciente.

Una “desviación significativa” con respecto al valor de referencia puede ser establecida por un experto en la materia mediante el uso de diferentes herramientas estadísticas, por ejemplo, pero sin limitarse, mediante la determinación de intervalos de confianza, determinación del valor p, test de Student o funciones discriminantes de Fisher; preferiblemente mediante las herramientas estadísticas descritas posteriormente en los ejemplos.

Los genes HSP90AB1, EEF2, STIP1, PSMC2, RAB10, NSUN2, CAPRIN1, SF3A1, COLGALT1, THEM6, CCT7, EIF2A y SRRM2 presentan una expresión aumentada en muestras procedentes de pacientes de cáncer de mama TNBC con un peor pronóstico, con respecto a la expresión cuantificada para esos mismos genes en una muestra de cáncer de mama ER+ con un buen pronóstico. A su vez, los genes HSPB6, COL1A1, APCS, DCN, SOD3, CTSG, COL6A1, COL6A2, COL6A3, PIP, CPA3, OGN, BGN, CMA1, AZGP1, LUM, PRELP, COL14A1, FMOD, CCDC40, NCAPG2, PRKCDBP y ASPN presentan una expresión reducida en muestras procedentes de pacientes de cáncer de mama TNBC con un peor pronóstico, con respecto a la expresión cuantificada para esos mismos genes en una muestra de cáncer de mama ER+ con un buen pronóstico.

En otra realización preferida, el método de la invención además comprende en la etapa (a) la cuantificación de la cantidad del producto de expresión de al menos uno de los genes incluidos en la firma genética MammaPrint, OncoType, Theros H/I, Prosigna o 8-gene Score, o cualquiera de sus combinaciones. Los genes biomarcadores que forman parte de estas firmas genéticas son los divulgados en la bibliografía correspondiente (MammaPrint divulgado en van 't Veer et al. Nature. 2002 Jan 31;415(6871):530-6; OncoType divulgado en Paik et al. N Engl J Med. 2004 Dec 30;351(27):2817-26, Theros H/I divulgado en Ma et al. J Clin Oncol. 2006 Oct 1;24(28):4611-9; Prosigna divulgado en Jorgensen CL, Nielsen TO, Bjerre KD, Liu S, Wallden B, Balslev E, et al. PAM50 breast cancer intrinsic subtypes and effect of gemcitabine in advanced breast cancer patients. Acta Oncol. 2013; y 8-gene Score divulgado en WO2010066928). Dentro del ámbito de la presente invención también se incluyen aquellos genes que co-expresan o se encuentran correlacionados con los genes de estas firmas genéticas.

Los pasos (a) y/o (b) del método de la invención pueden ser total o parcialmente automatizados, por ejemplo, pero sin limitarnos, mediante un equipo robótico para la cuantificación, en el paso (a), de la cantidad de producto de expresión del gen en la muestra biológica aislada.

Además de los pasos especificados anteriormente, el método de la invención puede comprender otros pasos adicionales, por ejemplo, aunque sin limitarnos, relacionados con el pre-tratamiento de la muestra biológica aislada previamente a su análisis.

El método de la presente invención puede incluir adicionalmente un paso en el cual, si se determina que el paciente presenta un mal pronóstico, se determine el tratamiento para el paciente.

El tratamiento principal del cáncer habitualmente suele ser la cirugía. En el caso del cáncer de mama, la cirugía suele consistir bien en una mastectomía o bien en una cirugía conservadora. La expresión “mastectomía”, tal y como se utiliza en la presente descripción, se refiere a la extirpación de la mama o de tanto tejido de la mama como esté afectado. En la mayoría de los casos, el cirujano extirpa también los ganglios linfáticos de la axila. La “expresión cirugía conservadora”, tal y como se utiliza en la presente descripción, se refiere a la extirpación del tumor pero no de la mama; también se conoce como tumorectomía, mastectomía segmentaria o mastectomía parcial.

Después de la cirugía, muchos pacientes reciben terapia adyuvante. El término “terapia adyuvante”, tal y como se utiliza en la presente descripción, se refiere al tratamiento que se da después del tratamiento principal con el objetivo de prevenir la recaída del cáncer en el seno o en otro lugar. En el tratamiento del cáncer, la terapia adyuvante puede consistir, por ejemplo, pero sin limitarse en radioterapia, quimioterapia, terapia hormonal o terapia biológica.

La quimioterapia adyuvante implica el uso de fármacos anticancerígenos, generalmente en combinación. Los más frecuentemente usados incluyen antraciclinas, tales como doxorubicina o epirubicina, 5-fluorouracilo, metotrexato, ciclofosfamida, y taxoides como el paclitaxel o docetaxel. La terapia hormonal adyuvante usa análogos de estrógenos tales como el tamoxifeno, que reduce el crecimiento de las células cancerosas bloqueando el receptor de estrógenos.

Algunos pacientes antes de la cirugía reciben terapia “neoadyuvante”. El término “terapia neoadyuvante”, tal y como se utiliza en la presente descripción, se refiere a la terapia adyuvante que se administra antes del tratamiento principal con el objetivo de reducir el tamaño del tumor, para posibilitar o facilitar la cirugía. En el tratamiento del cáncer dicha terapia, puede incluir, por ejemplo, pero sin limitarse, radioterapia, quimioterapia, terapia hormonal o terapia biológica.

La “radioterapia” consiste en el uso de radiaciones ionizantes para destruir las células cancerosas. Después de la cirugía conservadora de mama, la mayoría de los pacientes reciben radioterapia. Algunos pacientes reciben radioterapia después de una mastectomía. Algunos pacientes reciben radioterapia antes de la cirugía.

Los tumores positivos para receptores hormonales suelen tratarse con terapia hormonal con el objetivo de reducir o detener los efectos del estrógeno sobre las células tumorales. La terapia hormonal, puede consistir, por ejemplo, pero sin limitarse, en la administración de moduladores selectivos de receptores de estrógeno, inhibidores de aromatasa, agonistas de hormonas liberadoras de hormonas luteinizantes u otros agentes hormonales. Algunos moduladores selectivos de receptores de estrógeno son, por ejemplo, pero sin limitarse tamoxifeno, raloxifeno o toremifeno. Algunos inhibidores de aromatasa son, por ejemplo, pero sin limitarse letrozol, anastrozol o exemestano. Otras sustancias anti-estrogénicas: fulvestrant.

Otros agentes hormonales son, por ejemplo, pero sin limitarse, los andrógenos.

El TNBC es insensible a algunos de los tratamientos más eficaces disponibles para el cáncer de mama, incluyendo el tratamiento dirigido al HER2 como el trastuzumab y los tratamientos endocrinos como el tamoxifeno, o los inhibidores de la aromatasa. La quimioterapia citotóxica combinada, administrada en dosis densas o metronómicas, continúa siendo el tratamiento estándar en los TNBC en estadio temprano.

La “quimioterapia” consiste en el uso de compuestos o combinaciones de compuestos con el objetivo de destruir células cancerosas. Los compuestos administrados en la quimioterapia para el cáncer de mama pueden ser por ejemplo, pero sin limitarse, agentes alquilantes, antimetabolitos, inhibidores de la mitosis o antibióticos antitumorales. Algunos agentes alquilantes son, por ejemplo, pero sin limitarse, cisplatino, ciclofosfamida, dacarbazina, ifosfamida, mecloretamina o melfalán. Algunos antimetabolitos, son por ejemplo, pero sin limitarse, fluorouracilo, metotrexato, gemcitabina, citarabina o fludarabina. Algunos inhibidores de la mitosis son, por ejemplo, pero sin limitarse paclitaxel, docetaxel, etopósido, vinblastina, vincristina o vinorelbina. Algunos antibióticos antitumorales, son por ejemplo, pero sin limitarse bleomicina o antraciclinas. Algunas antraciclinas son, por ejemplo, daunorrubicina, doxorrubicina, epirrubicina o idarrubicina.

Otro aspecto de la invención se refiere a un kit, de ahora en adelante “kit de la invención”, que consiste en cebadores y/o sondas capaces de hibridar con los productos de expresión de los genes THEM6, COLGALT1, APCS, AZGP1, ASPN, CAPRIN1, CTSG, CPA3, CCDC40, CMA1, NCAPG2, COL1A1, COL6A1, COL6A2, COL6A3, COL14A1, EEF2, EIF2A, FMOD, HSP90AB1, HSPB6, LUM, OGN, NSUN2, BGN, DCN, PIP, PRKCDBP, PRELP, PSMC2, RAB10, SF3A1, SOD3, SRRM2, STIP1 y CCT7.

Otro aspecto de la invención se refiere al uso de un kit que comprende sondas y/o cebadores capaces de hibridar con los productos de expresión del gen THEM6, preferiblemente que además comprende sondas y/o cebadores capaces de hibridar con los productos de expresión de cualquiera de los genes seleccionados de la lista que consiste en: COLGALT1, APCS, AZGP1, ASPN, CAPRIN1, CTSG, CPA3, CCDC40, CMA1, NCAPG2, COL1A1, COL6A1, COL6A2, COL6A3, COL14A1, EEF2, EIF2A, FMOD, HSP90AB1, HSPB6, LUM, OGN, NSUN2, BGN, DCN, PIP, PRKCDBP, PRELP, PSMC2, RAB10, SF3A1, SOD3, SRRM2, STIP1 o CCT7, o cualquiera de sus combinaciones, para llevar a cabo el método de la invención. En una realización preferida de este aspecto de la invención, el kit es el kit de la invención descrito en el párrafo anterior.

Los kits descritos en la presente invención pueden comprender cebadores, sondas, anticuerpos poli o monoclonales, y todos aquellos reactivos necesarios para cuantificar y analizar la variación en el nivel de expresión de los genes por medio de cualquiera de los métodos descritos anteriormente en este documento y/o conocidos en el estado de la técnica. Los kits además pueden incluir, sin ningún tipo de limitación, el uso de tampones, enzimas, enzimas polimerasas, cofactores para obtener una actividad óptima de éstas, agentes para prevenir la contaminación, etc.

Los kits pueden contener además otras moléculas, genes, proteínas o sondas de interés, que sirvan como controles positivos y negativos. Por otro lado los kits pueden incluir todos los soportes y recipientes necesarios para su puesta en marcha y optimización. Preferiblemente, los kits comprenden además las instrucciones para llevar a cabo el método de la invención.

Los cebadores, sondas y/o anticuerpos comprendidos en los kits descritos en la invención presentan complementariedad, y por tanto, capacidad de hibridación, con al menos un producto de la expresión de cada uno de los genes descritos para el método de la invención.

El término “sonda”, tal y como se emplea en la presente descripción, se refiere a una molécula de ADN o ARN monocatenario con una secuencia de bases específica, preferiblemente marcada, que se utiliza para detectar secuencias de bases complementarias en el producto de la expresión de un gen por hibridación parcial o total. Las sondas pueden ser, por ejemplo, pero sin limitarnos, un oligonucleótido, un fragmento amplificado por PCR o un fragmento de ADN purificado. La expresión “sonda del producto de expresión del gen” se refiere a una sonda que permite detectar la expresión de dicho gen, es decir, se refiere a una sonda complementaria al ARNm o al ADNc de dicho gen.

El término “cebador”, como se utiliza aquí, se refiere a un oligonucleótido de ADN o ARN complementario a la secuencia de un ácido nucleico molde determinado, que actúa como punto de inicio para la adición de nucleótidos en el proceso de copia de la cadena complementaria a la secuencia de dicho ácido nucleico molde, por ejemplo, pero sin limitarnos en una PCR. Preferiblemente, el cebador es un oligonucleótido de ADN. La expresión “cebador del producto de expresión del gen” se refiere a un cebador que permite detectar la expresión de dicho gen, es decir, se refiere a un cebador complementario al ARNm o al ADNc de dicho gen. Cebadores que pueden emplearse en la presente invención son conocidos en el estado de la técnica o pueden diseñarse con facilidad a partir de la secuencia de los genes aquí descritos.

En una realización preferida, al menos uno de los anticuerpos de los kits de la invención está marcado o inmovilizado. En una realización más preferida, al menos uno de los anticuerpos de los kits de la invención está marcado con una etiqueta seleccionada de la lista que comprende: un radioisótopo, un marcador fluorescente o luminiscente, un anticuerpo, un fragmento de anticuerpo, una etiqueta de afinidad, una enzima y un substrato de una enzima. En una realización preferida, al menos uno de los anticuerpos de los kits de la invención está inmovilizado en una matriz de nylon, en un soporte de plástico o en cuentas.

A lo largo de la descripción y las reivindicaciones la palabra "comprende" y sus variantes no pretenden excluir otras características técnicas, aditivos, componentes o pasos. Para los expertos en la materia, otros objetos, ventajas y características de la invención se desprenderán en parte de la descripción y en parte de la práctica de la invención. Los siguientes ejemplos y figuras se proporcionan a modo de ilustración, y no se pretende que sean limitativos de la presente invención.

DESCRIPCIÓN DE LAS FIGURAS

FIG. 1. Clúster jerárquico en base a proteínas expresadas diferencialmente entre

pacientes de cáncer de mama positivo para receptores hormonales de

estrógeno (ER+) (gris oscuro, cuarta línea desde arriba) y pacientes de cáncer

de mama triple negativo (TNBC) (gris más oscuro, segunda línea desde arriba).

Aparecía un grupo de pacientes diagnosticadas como ER+ con un perfil más parecido a las TNBC, denominadas TNBC-like (gris más claro, primera línea desde arriba). Las que se mantenían como ER+ (gris claro, tercera línea desde arriba) se denominaron

ER-true.

FIG. 2. Clúster jerárquico en base a proteínas expresadas diferencialmente entre

ER-true (gris claro) y TNBC-like (gris oscuro).

FIG. 3. Evolución clínica de los subgrupos identificados mediante el clúster: ER-

true, TNBC-like y TNBC. Los dos últimos presentaron una evolución similar, siendo los grupos de peor pronóstico.

FIG. 4. Predictor TNBC-like en la población base.

FIG. 5. Firma de Adhesión en la población de pacientes ER+, nódulo linfático

positivo (LN+) (n=421) pertenecientes a la cohorte de validación.

FIG. 6. Firma de Adhesión por subtipos moleculares (A) LumA (n=363), (B) LumB

(n=223), (C) Normal (n=246), (D) Her2 (n=129) y (E) Basal (n=180).

FIG. 7. Perfiles comerciales aplicados sobre las pacientes ER+ de la cohorte de

validación (n=1028). A. Mammaprint. Clasifica en 2 grupos de riesgo (alto y bajo) B.

Combinación de Mammaprint con la Firma de Adhesión. A cada uno de los grupos de riesgo (alto y bajo), la Firma de Adhesión los subdivide en 2 nuevos grupos (ER-true o TNBC). C. Oncotype. Clasifica en 3 grupos de riesgo: bajo, intermedio y alto. D.

Combinación de Oncotype con la Firma de Adhesión. A cada uno de los grupos de riesgo del Oncotype, la Firma de Adhesión los subdivide en 2 nuevos grupos (ER-true

o TNBC). E. 8-geneScore. Clasifica en 2 grupos de riesgo (alto y bajo). F.

Combinación de 8-geneScore con la Firma de Adhesión. A cada uno de los grupos de riesgo (alto y bajo), la Firma de Adhesión los subdivide en 2 nuevos grupos (ER-true o TNBC).

FIG. 8. Genes correlacionados con los genes biomarcadores descritos para el

método de la invención.

EJEMPLOS

A continuación se ilustrará la invención mediante unos ensayos realizados por los inventores, que ponen de manifiesto la efectividad del método de pronóstico de la invención.

1. Material y métodos

1.1.

Selección de muestras.

Se seleccionaron 106 muestras parafinadas (FFPE) de pacientes diagnosticados de cáncer de mama. Nueve de ellas estaban disponibles en el Biobanco del Hospital Universitario La Paz, IdiPAZ (RD09/0076/00073) y las 97 restantes pertenecían al Biobanco del Hospital Universitario 12 de Octubre, I+12 (RD09/0076/00118), ambos integrados en la red Nacional de Biobancos (RetBioH; www.redbiobancos.es).

Únicamente se procesaron las muestras con un contenido mínimo de células tumorales del 50%. Sólo fueron incluidas en el estudio aquellas para las que había suficiente cantidad de proteína, así como aquellas para las que el número de péptidos fuera superior a la media menos 2 desviaciones estándar sobre el número total de péptidos identificados.

1.2.

Extracción y digestión de proteínas.

Las muestras FFPE se cortaron en un micrótomo. Cada corte se desparafinó en xileno y se lavó dos veces con etanol absoluto. Las muestras lavadas se resuspendieron en Tris-HCl 40 mM- 2% SDS, pH 8,2. A continuación se incubó la mezcla en un termobloque (Eppendorf) a 100°C durante 20 minutos seguido de 2 horas a 80° C (1).

A continuación, se centrifugaron a 15.000 x g durante 20 minutos a temperatura ambiente, y los pellets obtenidos fueron desechados. El extracto obtenido se guardó a -80 °C hasta ser utilizado (2). La concentración de proteínas se determinó usando el kit MicroBCA (Pierce-Thermo Scientific).

La digestión de los extractos (10 µg) se llevó a cabo con tripsina (1:50) y se eliminó el SDS de los lisados digeridos usando el kit Detergent Removal Spin Columns (Pierce).

A continuación las muestras fueron desaladas (ZipTips-Millipore), se secaron y se resolubilizaron en 15 µL de ácido fórmico al 0,1% y acetonitrilo al 3% antes de ser analizados por espectrometría de masas (2).

1.3.

Cromatografía líquida y espectrometría de masas.

Las muestras (4 µL) se analizaron en un espectrómetro de masas híbrido, LTQ- Orbitrap Velos (Thermo Fischer Scientific) acoplado a un sistema NanoLC-Ultra (Eksigent Technologies) de gran precisión. La separación de péptidos se llevó a cabo en una columna de fase reversa (75 µm × 150 mm) a una velocidad de flujo de 250 nL/min.

La composición del solvente fue ácido fórmico al 0,1% para el canal A y ácido fórmico al 0,1%/acetonitrilio al 99,9% para el canal B. Los péptidos se eluyeron con un gradiente de 5-30% de acetonitrilo en 95 minutos.

El espectrómetro operó en el modo data-dependent (DDA), adquiriendo un espectro de 300-1.700 m/z con una resolución de 30.000 a 400 m/z, seguido por una fragmentación CID (collision-induced dissociation) de las 20 señales más intensas cada ciclo. El automatic gain control (AGC) se estableció en 10.000 iones. Las muestras se calibraron empleando las señales m/z de 429,088735 y 445,120025, que corresponden a péptidos conocidos.

1.4.

Procesamiento de datos de expresión de proteínas.

Los datos adquiridos por espectrometría de masas (MS) se procesaron con el software MaxQuant (versión 1.2.7.4) (3) y mediante el motor de búsqueda Andromeda, se procedió a la identificación de proteínas (4). Para identificar los espectros, se compararon con los de las bases de datos humanas UniProtKB/Swiss- Prot. La carbamidometilación de la cisteína se asumió como una modificación fija, mientras que la oxidación (M), desamidación (N, Q) y la acetilación en el extremo N- terminal como modificaciones variables. La tasa de falsos descubrimientos (FDR) máxima fue de 0,01 para péptidos y 0,05 para proteínas.

La cuantificación sin marcaje se llevó a cabo estableciendo ventanas de 2 minutos entre las múltiples carreras. La abundancia de proteínas se calculó en base a la intensidad del espectro proteico normalizado (intensidad LFQ).

Como proteínas cuantificables, se seleccionaron aquellas que fueran detectadas en al menos un 75% de las muestras dentro de al menos un grupo (ER+ o TNBC), y que contaran con, al menos, dos péptidos únicos. Sólo estas proteínas fueron consideradas para análisis posteriores.

Los datos obtenidos para las proteínas, en un primer paso se transformaron (log2), y tal como está descrito en (5), se imputaron los valores nulos. Por último, estos valores de expresión se centraron (z-score) y los efectos de grupo se corrigieron usando ComBat (“Combating Batch Effects When Combining Batches of Gene Expression Microarray Data”) (6). Este software está basado en un método empírico Bayesiano; corrige los efectos de grupo estandarizando la media y la varianza entre los grupos (7).

1.5.

Análisis de supervivencia.

Para identificar proteínas expresadas de forma diferencial entre las pacientes ER+ (71 pacientes) y las TNBC (25 pacientes) se llevó a cabo un análisis de expresión diferencial empleando SAM (Significance Analysis of Microarrays) (8) con un “False Discovery Rate” por debajo del 5% (estimación de la proporción de proteínas que han podido salir como significativos al azar).

Con las proteínas significativas se construyeron clusters jerárquicos usando la correlación de Pearson y el método de average-linkage (método para calcular la distancia entre clusters; el average-linkage entre dos clusters se calcula como la distancia media entre los componentes de cada clúster). A continuación, se calculó un nivel de significación estadístico para cada proteína en base a un modelo univariante (6) con el fin de identificar los genes cuya expresión estuviera significativamente relacionada con la supervivencia libre de metástasis (en inglés, “distant metastasis- free survival“ DMFS) como esta descrito en (9). Brevemente, las proteínas relacionadas con DMFS fueron filtradas en base a sus p-valores. Aquellas con un p- valor<0,01 se seleccionaron para desarrollar modelos de predicción de riesgo utilizando el método de componentes principales supervisado de E. Bair and R.

Tibshirani (10). Además, entre las proteínas seleccionadas se establecieron grupos de correlación con el fin de encontrar perfiles reducidos. La validación cruzada (Leave-

one-out cross-validation) se utilizó para evaluar la precisión en cuanto a la predicción de los perfiles (cada una de las muestras a nivel individual se considera cohorte de validación, y es sobre la que se analiza el perfil obtenido. El proceso se repite hasta que todas las muestras hayan pasado por esa etapa). Se considera a una determinada muestra como datos de validación, y a las restantes como los datos muestrales. Esto se repite de tal manera que cada muestra se utiliza una vez como datos de validación. Para probar la significación estadística y descartar que hubiese ocurrido por un proceso al azar, los perfiles fueron sometidos a 1.000 permutaciones aleatorias. Además, por el hecho de usar permutaciones, se detectaron correlaciones entre genes, evitando así el hecho de asumir situaciones paramétricas en la distribución de genes. Esto es una ventaja sobre otras técnicas (ANOVA, Bonferroni), las cuales asumen igualdad de varianzas y/o independencia de genes.

La eficiencia de estos modelos se evaluó por el área bajo la curva (AUC) de las curvas ROC, que consisten en una representación gráfica de la sensibilidad frente a (1 – especificidad) (11). Los análisis se realizaron en el programa BRB-ArrayTools v4_2_1, desarrollado por el Dr. Richard Simon y BRB-ArrayTools Equipo de Desarrollo.

1.6.

Predictores de riesgo.

Los predictores de riesgo, realizados en BRB-Array Tools, están basados en el Compound Covariate Predictor (12), Diagonal Linear Discriminant Analysis (13), Nearest Neighbor Classification (13) y Support Vector Machines with linear kernel (14).

Están compuestos por un conjunto de genes con expresión diferencial al nivel 0,05 del random variance t-test (15) y que tenían tanto datos de expresión de proteínas como de genes (para la meta-validación). El error de predicción se estimó usando leave- one-out cross-validation (LOOCV), como está descrito en (16). Para cada conjunto de datos LOOCV se repitió todo el proceso de construcción de modelos, incluyendo el proceso de selección de genes. También se evaluó si la estimación de la tasa de error por validación cruzada era significativamente menor de lo que cabría esperar de predicción aleatoria (por permutaciones). El nivel de significación es, por tanto, la proporción de las permutaciones aleatorias que dieron una tasa de error menor que la tasa de error obtenida con los datos reales. Para probar la significación estadística del punto de corte, se evaluó el valor p del estadístico log-rank test entre los grupos de riesgo mediante 1.000 permutaciones aleatorias.

Cuando se estudiaron posibles diferencias entre las pacientes ER+ y TNBC, además de las proteínas, se analizaron datos de expresión de miRNAs. Se utilizó la base de datos miRWalk (version 15 de Marzo de 2013) (17) para encontrar posibles dianas de los miRNAs entre las proteínas identificadas con el SAM.

1.7.

Análisis ontológico.

Al tener bases de datos tanto de expresión proteica como de expresión génica, fue necesario hacer una conversión gen-proteína. Para ello, en un primer lugar se utilizó la base de datos Uniprot (http://www.uniprot.org), cuya misión es proporcionar información a la comunidad científica en cuanto a lo que se refiere a secuencia y funcionalidad de la proteína. Reúne además resultados experimentales sobre cada una de las proteínas.

Teniendo el nombre oficial de la proteína, así como del gen, a continuación se usó la base de datos DAVID (Database for Annotation, Visualization and Integrated Discovery v6.7) (18, 19). Esta base proporciona un conjunto de anotaciones funcionales para conocer el significado biológico que hay detrás esos genes, agrupándolos a su vez en clusters según su funcionalidad. Además, permite establecer asociaciones gen-enfermedad y visualizar los genes en los mapas de las rutas de Biocarta, KEGG y Panther aportando referencias bibliográficas en las que se hace mención al gen/genes de interés.

Para el análisis ontológico en esta base de datos, se acotaron los resultados a la lista de “homo sapiens”, la categoría GOTERM-FAT y las rutas Biocarta, KEGG y Panther.

1.8.

Verificación ortogonal.

Se construyó una gran base de datos de expresión génica (cohorte de validación) compuesta por 1.296 pacientes con carcinomas mamarios primarios, y 32.339 valores de expresión génica, obtenida de dos trabajos publicados previamente (20, 21).

Además, los subtipos moleculares de las pacientes se asignaron usando el algoritmo Single Sample Predictor (SSP) descrito por Hu et al. (22) y usado por Fan et al. (23).

Combinar datos de diferentes experimentos de microarrays es una gran ventaja, ya que permite trabajar con un número mayor de muestras, dando un mayor poder estadístico a los resultados. No obstante, hay que tener cuidado con los efectos de grupo que se generan cuando las muestras son procesadas en días o grupos diferentes, o por distinta gente. En este caso, los efectos de grupo que surgen entre las dos bases de datos se corrigieron con el software ComBat (6).

Al trabajar con datos de expresión proteica en las muestras empleadas y de expresión génica en la base de datos construida, había que hacer la conversión proteína-gen.

Una vez hecha esta conversión, se seleccionaron todos los ensayos para los genes de interés y, en aquellos casos en los que hubiera varias entradas para un mismo gen, se seleccionó aquel con mayor desviación estándar.

En esta cohorte de validación, además de los datos de expresión génica, estaban disponibles los datos de supervivencia libre de enfermedad así como la recaída o no y su estatus de receptor de estrógenos, pero no se conocía ni el estatus de Her2, ni el de PR, ni el tratamiento recibido por las pacientes. Esto suponía un problema en cuanto a la selección de pacientes TNBC. Para conseguir una mayor precisión, se seleccionaron aquellas pacientes ER- con niveles de expresión de PGR<12 y de ERBB2<11.8 como esta descrito por otros grupos (24, 25).

1.9.

Análisis estadístico.

Para el análisis estadístico se utilizaron los programas BRB-ArrayTools, SPSS v16, GraphPad Prism 5.1 y R v2.15.2 (con el paquete Design 0.2.3). Todos los p-valores se consideraron estadísticamente significativos cuando eran por debajo de 0,05. Los datos de expresión se centraron y se analizaron en MeV (26) y Cytoscape (27).

2. Resultados

2.1. Análisis de proteínas “label-free”: 224 proteínas diferenciales.

Haciendo un estudio paralelo pero partiendo del mismo SAM inicial (con 1085 proteínas), se trabajó con 224 proteínas expresadas de forma diferencial entre ER+ y TNBC con un FDR<5%. Se construyó un clúster jerárquico usando la expresión de esas 224 proteínas (Figura 1). Lo que se puede observar a simple vista es que hay un grupo de pacientes que han sido diagnosticadas clínicamente como ER+ pero cuyo perfil de expresión tiene más similitud con el grupo TNBC que con el mismo ER+. A estas pacientes ER+ con tendencia a TNBC, se les denominó en el presente trabajo como TNBC-like. Las ER+ que se mantenían como tal, recibieron el nombre de ER-

true.

2.2. ER-true vs. TNBC-like.

Para tratar de reducir el número de proteínas diferenciales entre las pacientes ER+ true y TNBC-like, se hizo de nuevo un SAM, pero en este caso sólo con estos 2 grupos (dejando ya fuera a las TNBC, centrando el estudio en las ER+). Con este nuevo SAM, partiendo del total de las 1.085 proteínas, 44 de ellas presentaban una expresión diferencial (Figura 2).

2.3. Evolución clínica de las pacientes.

En base a los clusters, al identificar un nuevo posible subgrupo de pacientes, se trabajó con las muestras clasificadas como: ER+-true, TNBC-like y TNBC. Para conocer un poco mejor el comportamiento de este nuevo grupo TNBC-like, tanto a nivel clínico como a nivel molecular, se analizó el perfil de supervivencia de estos tres grupos mediante las gráficas Kaplan-Meier (estimador no paramétrico de la función de supervivencia), cuyo objetivo es estimar la probabilidad de supervivencia de un grupo de pacientes en un intervalo de tiempo definido (Figura 3). En el grupo TNBC-like, la supervivencia libre de metástasis (DMFS) a los 5 años fue de 71,1% mientras que en las ER-true de 88% (p-valor=0.24). De nuevo lo que se puede observar es que los tumores con características de TNBC-like no sólo tienen un perfil molecular más parecido a los tumores TNBC, sino que además, la evolución clínica de estas pacientes es también muy parecida, siendo los grupos con peor pronóstico.

2.4. Predictor TNBC-like.

El siguiente paso consistió en verificar si esa tendencia que aparecía en la población ensayada se podía validar en una cohorte mayor. Como no hay bases de datos de expresión proteica en grandes poblaciones, se trabajó con la base de datos de expresión génica de 1296 pacientes. Para ello, partiendo de las 44 proteínas significativas del SAM (Figura 2), se hizo la conversión a genes. Durante esta conversión, se perdieron 6 proteínas (en la base de datos Swissprot, 3 salían desconocidas y otras 3 sin referencias), por lo que quedaron 38. Al buscarlas en la base de datos de expresión génica, 2 de ellas no aparecían, por lo que al final, se trabajó con 36 proteínas/genes.

Se diseñó un predictor de clase (denominado “predictor TNBC-like”) usando la herramienta “Class Prediction” de BRB-ArrayTools a partir de la población de pacientes ER+ (clasificadas por el clúster) (Figura 4). A pesar de que el p-valor no salía significativo (p=0.086), se veía de nuevo una tendencia, que se comprobó en la base de datos de validación, sobre 421 pacientes (ER+, LN+). En este caso, el p-valor fue de 0.0047, por lo que tanto el predictor como la tendencia se validaban.

Una vez validado el predictor, había que profundizar un poco sobre las proteínas que lo componían, por lo que se realizó un análisis ontológico (Swissprot y DAVID).

Curiosamente, la mayoría de las 36 proteínas estaban relacionadas con procesos de adhesión. Con esta información, el predictor TNBC-like pasó a llamarse “Firma de Adhesión”.

2.5. Validación por subtipos.

Una vez obtenido un predictor con peso, el paso siguiente fue la verificación de su validación. Para ello se cogió la cohorte de validación con las 1296 pacientes y, en un primer lugar, se validó el predictor en toda la población de pacientes ER+ con ganglios positivos (n=421). En este caso salía significativo (p=0.0047) (Figura 5).

La siguiente prueba de validación que se llevó a cabo consistió en aplicar el predictor a cada uno de los subgrupos moleculares de pacientes por separado, es decir, en LumA (n=363), LumB (n=223), Basal (n=180), Normal (n=246) y Her2 (n=129). En este caso lo que ocurría es que sólo para el subgrupo LumA (pacientes que son generalmente ER+ con buen pronóstico) aparecían diferencias significativas entre ambos grupos (Figura 6).

2.6. TNBC-like vs. Mammaprint, Oncotype y 8-genes Score.

Una vez comprobado que el predictor diseñado se validaba en una población de pacientes, se pasó a compararlo con los perfiles existentes mencionados anteriormente (Mammaprint, Oncotype y 8-gene-Score). Para ello se aplicó cada test a las pacientes ER+ de la cohorte de validación (752 pacientes).

Estos perfiles comerciales están basados principalmente en genes de proliferación mientras que la Firma de Adhesión aquí propuesta, como su nombre indica, lo hace en genes de adhesión. Cuando se combinaron parejas de perfiles en la población de pacientes (Firma de Adhesión + Mammprint/Oncotype/8-gene) se vio que la Firma de Adhesión aportaba una información extra a la proporcionada por los otros (Figura 7).

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P201430887 ES 2 553 786 A1 27-10-2014  

REIVINDICACIONES

1. Método para el pronóstico in vitro de un sujeto que presenta un tumor, que comprende: a.

Cuantificar, en una muestra biológica aislada que comprende células tumorales de dicho sujeto, la cantidad del producto de la expresión del gen THEM6, y b.

comparar la cantidad cuantificada en la etapa (a) con un valor de referencia.

2. Método según la reivindicación 1, donde el tumor es de mama.

3. Método según la reivindicación 2, donde el tumor es HER2 negativo o positivo para la expresión de los receptores hormonales de estrógenos.

4. Método según cualquiera de las reivindicaciones 1 a 3, donde el valor de referencia del paso (b) se obtiene tras la cuantificación del producto de expresión del gen de la etapa (a) en una muestra biológica aislada que comprende células tumorales de un individuo que presenta un tumor de mama triple negativo.

5. Método según la reivindicación 4, que además comprende un paso (c) donde si la cantidad cuantificada en el paso (a) no presenta una desviación significativa con respecto al valor de referencia con el que se compara en el paso (b), se asigna al sujeto al grupo de pacientes con un mal pronóstico.

6. Método según la reivindicación 5, donde el mal pronóstico se refiere a un alto riesgo de recaída y/o de metástasis.

7. Método según cualquiera de las reivindicaciones 1 a 6, donde el producto de expresión del gen es mRNA o proteína.

8. Método según cualquiera de las reivindicaciones 1 a 7, donde la muestra biológica aislada que comprende células tumorales está fijada en formalina y embebida en parafina.

9. Método según cualquiera de las reivindicaciones 1 a 8 donde el sujeto es un humano.

P201430887 ES 2 553 786 A1 27-10-2014   10. Método según cualquiera de las reivindicaciones 1 a 9 donde el sujeto ha estado previamente sometido a una terapia antitumoral.

11. Uso de un kit que comprende sondas y/o cebadores capaces de hibridar con los productos de expresión del gen THEM6, para llevar a cabo el método según cualquiera de las reivindicaciones 1 a 10.

FIG. 1

37

FIG. 3

Supervivencia 100 90 80 ER+-true TNBC-like o r c e n t a j e d e s u p e r v i v e n c i a P TNBC 0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Tiempo (años) 39

FIG. 4

Supervivencia

100

c i a

80

e r v i v e n

p 60 e s u

t a j e d

40

ER+-true P P value valor 0.0860

r c e n

TNBC-like

o P 20

0 0

2

4

6

8

10

12

14

Tiempo (años)

FIG. 5

Firma de Adhesión 100 e d a d 80 ER+-true TNBC-like s u p e r v i v e n c i a l i b r e d e e n f e r m % P value P valor 0.0047 0 0 100 150 200 250 300 350 400 Tiempo (meses) 41

FIG. 6

A

Supervivencia LumA

100

90

80

70

60

50

ER+-true

40

TNBC-like

30

o r c e n t a j e d e s u p e r v i v e n c i a

20

P 10

0 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150

Tiempo (meses)

B

Supervivencia LumB

100

90

c i a

80

70

r v i v e n e rvival 60 s u p e t su

50

d j e

40

t a ercenP 30

ER+-true r c e n o

20

TNBC-like P

10

0 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150

Time

Tiempo (meses) 42

FIG. 6 (cont.)

C

Supervivencia Normal

100

90

c i a

80

70

r v i v e n ervial 60 s u p

t 50

ER+-true e d 40

TNBC-like j eercen t aP 30 r c e n

20

o P 10

0 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150

Time

Tiempo (meses)

D

Supervivencia Her2

100

90

c i a

80

70

r v i v e n ervival 60 s u p et 50

d 40

j e ER+-true t aercenP 30

TNBC-like r c e n

20

o P 10

0 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150

Time

Tiempo (meses) 43

FIG. 6 (cont.)

E

Supervivencia Basales

100

90

c i a

80

70

r v i v e n

v i a l

e

60

s ur

s u p

50

ER+-true e d

40

TNBC-like j e ercent t a P 30

20

r c e n o P

10

0 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150

Time

Tiempo (meses) 44

FIG. 7

A Mammaprint e d a d 100 80 Low Risk Riesgo bajo High Risk Riesgo alto s u p e r v i v e n c i a l i b r e d e e n f e r m 90 120 150 180 % Tiempo (meses) B Mammaprint + TNBC-like e d a d 100 80 ER-true low ER-true bajo TNBC-like bajo TNBC-like low ER-t ER-rue high true alto TNBC-lik TNBC- e high like alto s u p e r v i v e n c i a l i b r e d e e n f e r m 90 120 150 180 % Tiempo (meses)

FIG. 7 (cont.)

C Oncotype e d a d 100 80 Low Risk Riesgo bajo Intermediate Risk Riesgo intermedio High Risk Riesgo alto s u p e r v i v e n c i a l i b r e d e e n f e r m 90 120 150 180 % Tiempo (meses) D Oncotype + TNBC-like e d a d 100 80 ER ER-t-rue low true bajo TNBC-like low TNBC-like bajo ER-t - rue intermediat true intermedio e TNBC-like intermediate TNBC-like intermedio ER ER -t - rue high true alto TNBC TNBC--like high like alto s u p e r v i v e n c i a l i b r e d e e n f e r m 90 120 150 180 % Tiempo (meses) 46

FIG. 7 (cont.)

E 8-geneScore e d a d 100 80 d e e n f e r m Riesgo bajo Low Risk r v i v e n c i a l i b r e High Ris Riesgo k alto s u pe 90 120 150 180 % Tiempo (meses) F 8-geneScore + TNBC-like e d a d 100 80 ER-T ER- rue-low true bajo TNBC-Like-low TNBC-like bajo ER-T ER- rue-High true alto TNBC-Like-High TNBC-like alto s u p e r v i v e n c i a l i b r e d e e n f e r m 90 120 150 180 % Tiempo (meses) 47

FIG. 8

APCS Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_014576 A1CF Hs00205840_m1 NM_020469 ABO Hs00220850_m1 NM_001009185 ACSL6 Hs00362960_m1 NM_006687 ACTL7A Hs00246418_s1 AF029899 ADAM20 Hs01083178_s1 NM_052853 ADCK2 Hs00934133_m1 NM_000682 ADRA2B Hs00265090_s1 NM_001619 ADRBK1 Hs00176395_m1 NM_002025 AFF2 Hs00171400_m1 NM_006076 AGFG2 Hs00331724_s1 NM_012190 ALDH1L1 Hs00201836_m1 AK026411 ALDOB Hs01551887_m1 NM_020547 AMHR2 Hs00179718_m1 NM_015985 ANGPT4 Hs00907078_m1 NM_004308 ARHGAP1 Hs00188815_m1 NM_017700 ARHGEF38 Hs00214498_m1 NM_018076 ARMC4 Hs00259786_m1 NM_004314 ART1 Hs00188841_m1 NM_020646 ASCL3 Hs00221027_m1 NM_024490 ATP10A Hs00257114_m1 NM_001676 ATP12A Hs01060284_m1 NM_000707 AVPR1B Hs00704725_s1 NM_030765 B3GNT4 Hs01867372_s1 NM_004324 BAX Hs99999001_m1 AB032253 BAZ1B Hs00224831_m1 NM_001008405 BCAP29 Hs00218964_m1 NM_152733 BTBD9 Hs00298028_s1 AK023540 BUB1 Hs00177821_m1 NM_015652 C10orf12 Hs00249021_s1 NM_174943 C14orf178 Hs00752598_s1 NM_014117 C16orf72 Hs00415599_m1 NM_006365 C1orf61 Hs00197247_m1 NM_001738 CA1 Hs01100176_m1 NM_005182 CA7 Hs00193128_m1 NM_019855 CABP5 Hs00251995_m1 AF227750 CACNA1G Hs00367969_m1 NM_000722 CACNA2D1 Hs00984856_m1 NM_000723 CACNB1 Hs00609497_m1 NM_021189 CADM3 Hs01003862_m1 NM_015981 CAMK2A Hs00211096_m1 48 NM_001220 CAMK2B Hs00365799_m1 NM_024046 CAMKV Hs00225234_m1 AF111345 CASP10 Hs01017902_m1 U20760 CASR Hs01047795_m1 NM_001234 CAV3 Hs00154292_m1 NM_031290 CCDC70 Hs00229861_m1 NM_012118 CCRN4L Hs00232597_m1 U96627 CD84 Hs00174668_m1 NM_001790 CDC25C Hs00156411_m1 NM_006382 CDRT1 Hs00275997_m1 NM_001804 CDX1 Hs00156451_m1 NM_001817 CEACAM4 Hs00958102_g1 BC005918 CELA3A Hs00371670_m1 D00306 CELA3A Hs00371670_m1 NM_005454 CER1 Hs00193796_m1 NM_021797 CHIA Hs00757767_m1 NM_000742 CHRNA2 Hs00181237_m1 BC006114 CHRNA3 Hs01095115_m1 NM_000748 CHRNB2 Hs00181267_m1 NM_000749 CHRNB3 Hs00181269_m1 NM_006383 CIB2 Hs00197280_m1 U18288 CIITA Hs00172106_m1 NM_012131 CLDN17 Hs01043467_s1 NM_016369 CLDN18 Hs00212584_m1 NM_004898 CLOCK Hs00231857_m1 NM_001841 CNR2 Hs00361490_m1 NM_001842 CNTFR Hs00181798_m1 NM_152516 COMMD1 Hs00415059_m1 NM_001869 CPA2 Hs00157009_m1 NM_001308 CPN1 Hs01014876_m1 NM_000567 CRP Hs00265044_m1 NM_022644 CSH2 Hs00831897_s1 NM_000634 CXCR1 Hs01921207_s1 NM_000106 CYP2D6 Hs02576168_g1 AF280110 CYP3A43 Hs00256159_m1 D13705 CYP4A11 Hs00167961_m1 NM_000787 DBH Hs01089840_m1 NM_005215 DCC Hs00180437_m1 NM_017639 DCHS2 Hs00214191_m1 AB000277 DLGAP1 Hs00924702_m1 NM_023932 DLK2 Hs01106587_m1 NM_017539 DNAH3 Hs00296171_m1 NM_023036 DNAI2 Hs00224913_m1 NM_018602 DNAJA4 Hs00388055_m1 NM_015291 DNAJC16 Hs00406457_m1 49 NM_013369 DNMT3L Hs01081364_m1 M30625 DRD2 Hs01024460_m1 NM_000795 DRD2 Hs01024460_m1 NM_000798 DRD5 Hs00361234_s1 NM_001939 DRP2 Hs00157301_m1 NM_005867 DSCR4 Hs00862205_m1 NM_024025 DUSP26 Hs00225167_m1 U52373 DYRK1A Hs00176369_m1 NM_001950 E2F4 Hs00608098_m1 NM_021783 EDA2R Hs00222305_m1 U57001 EFNB3 Hs00154861_m1 NM_001965 EGR4 Hs00231095_m1 NM_003760 EIF4G3 Hs00186804_m1 NM_153265 EML3 Hs00401524_m1 NM_005232 EPHA1 Hs00975876_g1 NM_014285 EXOSC2 Hs00204705_m1 NM_017678 FAM55D Hs00214388_m1 NM_152660 FAM76A Hs00295301_m1 U90941 FCGR2C Hs00269605_m1 NM_014375 FETUB Hs00608480_m1 AF171928 FGF5 Hs03676587_s1 NM_005197 FOXN3 Hs00830558_g1 U81501 FPR2 Hs02759175_s1 AF334946 FRMD8 Hs00607699_mH M95489 FSHR Hs00174865_m1 NM_016263 FZR1 Hs00393592_m1 NM_000809 GABRA4 Hs00608034_m1 NM_017417 GALNT8 Hs00213610_m1 NM_020634 GDF3 Hs00220998_m1 NM_024707 GEMIN7 Hs00226769_m1 NM_022139 GFRA4 Hs00360831_g1 NM_000167 GK Hs02340011_g1 NM_147193 GLIS1 Hs00377690_m1 NM_002062 GLP1R Hs01006332_m1 NM_024312 GNPTAB Hs00393389_m1 NM_020155 GPR137 Hs00220079_m1 NM_005290 GPR15 Hs00922903_s1 NM_018969 GPR173 Hs00255846_s1 NM_007264 GPR182 Hs01922099_s1 NM_018971 GPR27 Hs00251809_s1 NM_004224 GPR50 Hs00173684_m1 NM_018654 GPRC5D Hs03045339_m1 AF015731 GRIN1 Hs00609557_m1 AF015730 GRIN1 Hs00609557_m1 D13515 GRIN1 Hs00246956_m1 U11287 GRIN2B Hs00168230_m1 U90278 GRIN2B Hs00168230_m1 L40027 GSK3A Hs00219856_m1 NM_004286 GTPBP1 Hs00534836_s1 NM_000409 GUCA1A Hs00181172_m1 NM_002098 GUCA1B Hs00361600_m1 NM_002099 GYPA Hs00266777_m1 NM_002100 GYPB Hs03044427_m1 NM_002100 GYPB Hs03044427_m1 AF040723 HAP1 Hs00355440_m1 NM_005477 HCN4 Hs00975492_m1 NM_015052 HECW1 Hs00389648_m1 NM_022462 HIF3A Hs00223818_m1 M57732 HNF1A Hs01551752_m1 NM_000457 HNF4A Hs01023298_m1 NM_022304 HRH2 Hs00254569_s1 NM_007232 HRH3 Hs00200610_m1 NM_000870 HTR4 Hs00168380_m1 NM_015259 ICOSLG Hs00323621_m1 NM_018262 IFT122 Hs00217508_m1 NM_005535 IL12RB1 Hs00234651_m1 NM_002190 IL17A Hs00174383_m1 AB012701 IL1RL1 Hs00545038_g1 NM_022789 IL25 Hs03044841_m1 M75914 IL5RA Hs00602482_m1 NM_000564 IL5RA Hs00236871_m1 M96651 IL5RA Hs00602482_m1 NM_005538 INHBC Hs03986132_s1 NM_017759 INO80D Hs00214850_m1 NM_000632 ITGAM Hs00355885_m1 AF182199 ITSN2 Hs00536891_m1 NM_003724 JRK Hs00374396_s1 NM_004977 KCNC3 Hs00192108_m1 NM_012285 KCNH4 Hs00202206_m1 U03884 KCNJ1 Hs00531188_m1 D50134 KCNJ5 Hs00168476_m1 NM_002248 KCNN1 Hs00158457_m1 NM_004653 KDM5D Hs01104406_g1 NM_021013 KRT34 Hs00606019_gH NM_002283 KRT85 Hs00158558_m1 NM_015155 LARP4B Hs00833057_s1 NM_002305 LGALS1 Hs00355202_m1 AF156888 LHX3 Hs01033412_m1 NM_002314 LIMK1 Hs00242731_m1 D50550 LLGL1 Hs00188098_m1 51 NM_021819 LMAN1L Hs00222386_m1 AF117949 LOXL2 Hs00158757_m1 NM_006338 LRRN2 Hs00180696_m1 NM_016383 LUZP4 Hs00212609_m1 NM_021020 LZTS1 Hs00232762_m1 NM_002446 MAP3K10 Hs00374249_m1 NM_006610 MASP2 Hs00198244_m1 NM_002379 MATN1 Hs00159075_m1 NM_000529 MC2R Hs00300820_s1 NM_014815 MED24 Hs00207863_m1 NM_005925 MEP1B Hs00195535_m1 NM_014160 MKRN2 Hs00274055_m1 NM_005940 MMP11 Hs00171829_m1 AB009303 MMP16 Hs00234676_m1 NM_015134 MPRIP Hs00819388_m1 NM_000431 MVK Hs00176077_m1 NM_000256 MYBPC3 Hs00165232_m1 NM_002472 MYH8 Hs00267293_m1 NM_001002841 MYL4 Hs00267321_m1 NM_016239 MYO15A Hs02568467_s1 U63041 NCAM1 Hs00169851_m1 NM_016453 NCKIPSD Hs00356575_m1 NM_004829 NCR1 Hs00183118_m1 NM_004828 NCR2 Hs00183113_m1 NM_006656 NEU3 Hs00198406_m1 NM_021191 NEUROD4 Hs01850960_s1 NM_022728 NEUROD6 Hs00745618_s1 NM_000620 NOS1 Hs00167223_m1 NM_014625 NPHS2 Hs00922492_m1 U59431 NPY6R Hs00246222_s1 NM_005122 NR1I3 Hs00231959_m1 NM_001489 NR6A1 Hs00364256_m1 D14689 NUP214 Hs01090093_m1 NM_013941 OR10C1 Hs00273849_s1 NM_012351 OR10J1 Hs00273418_s1 NM_030883 OR2H1 Hs01894157_s1 NM_019897 OR2S2 Hs00252047_s1 NM_017506 OR7A5 Hs00758531_s1 NM_012377 OR7C2 Hs00247330_s1 NM_013358 PADI1 Hs00203458_m1 AF311940 PAPPA2 Hs00395734_m1 NM_000438 PAX3 Hs00240950_m1 NM_013340 PCDHB1 Hs00247446_s1 NM_018916 PCDHGA3 Hs00251717_m1 AF152516 PCDHGA9 Hs00259365_s1 52 NM_000923 PDE4C Hs00971857_mH NM_002608 PDGFB Hs00234042_m1 NM_003687 PDLIM4 Hs00184792_m1 NM_024791 PDZD3 Hs00227168_m1 NM_002619 PF4 Hs00236998_m1 NM_020393 PGLYRP4 Hs01120180_m1 NM_015157 PHLDB1 Hs00384827_m1 NM_018068 PIWIL2 Hs00216263_m1 M15465 PKLR Hs00176075_m1 NM_022062 PKNOX2 Hs00222872_m1 NM_015184 PLCL2 Hs00392897_m1 NM_015993 PLLP Hs00762550_s1 AF230401 PML Hs00971694_m1 NM_006229 PNLIPRP1 Hs00173824_m1 NM_004576 PPP2R2B Hs00270227_m1 NM_006247 PPP5C Hs00196577_m1 U42387 PPYR1 Hs00275980_s1 K03206 PRB1 Hs00818764_m1 NM_005039 PRB1 Hs00818764_m1 K03205 PRB1 Hs00818764_m1 NM_002723 PRB4 Hs00864002_m1 NM_020228 PRDM10 Hs00999749_m1 NM_020229 PRDM11 Hs00220293_m1 NM_002761 PRM1 Hs00358158_g1 NM_021232 PRODH2 Hs00560403_m1 AF076215 PROP1 Hs00395073_m1 NM_004676 PRY Hs00190725_m1 NM_021016 PSG3 Hs00360732_m1 NM_004158 PSPN Hs03986122_s1 NM_000965 RARB Hs00977140_m1 NM_203390 RBM12B Hs00736582_m1 AF031549 RHAG Hs00914753_m1 NM_020407 RHBG Hs00220735_m1 NM_000539 RHO Hs00892431_m1 NM_002939 RNH1 Hs00161407_m1 BC002550 RPS12 Hs00831630_g1 NM_014496 RPS6KA6 Hs00179523_m1 NM_015179 RRP12 Hs00958380_m1 NM_004348 RUNX2 Hs00298328_s1 NM_006514 SCN10A Hs01045137_m1 NM_001039 SCNN1G Hs00168918_m1 BC005913 SFTPC Hs00161628_m1 NM_003018 SFTPC Hs00161628_m1 NM_003018 SFTPC Hs00161628_m1 NM_000451 SHOX Hs00757860_g1 53 NM_015360 SKIV2L2 Hs00299011_m1 NM_020309 SLC17A7 Hs00220404_m1 BC000651 SLC1A7 Hs00198515_m1 NM_004803 SLC22A14 Hs00899722_m1 NM_016609 SLC22A17 Hs00414311_g1 NM_003041 SLC5A2 Hs00894642_m1 D87920 SLC5A5 Hs00166567_m1 AF168619 SPAG11A Hs00414469_m1 NM_012391 SPDEF Hs01026048_m1 NM_015087 SPG20 Hs00374834_m1 NM_000347 SPTB Hs01024103_m1 NM_014178 STXBP6 Hs00274072_m1 NM_033025 SYDE1 Hs00263581_m1 NM_003898 SYNJ2 Hs00975687_m1 NM_177963 SYT12 Hs00698267_m1 NM_003967 TAAR5 Hs00269590_s1 NM_013251 TAC3 Hs00203109_m1 NM_004606 TAF1 Hs00542346_s1 NM_003189 TAL1 Hs01097987_m1 NM_015079 TBC1D2B Hs00534954_m1 NM_004608 TBX6 Hs00365539_m1 U11271 TBXA2R Hs00169054_m1 NM_014972 TCF25 Hs00248217_m1 NM_031273 TEX13B Hs00364019_g1 NM_001586 TEX28 Hs01561622_m1 NM_030770 TMPRSS5 Hs00893588_m1 NM_006034 TP53I11 Hs00271970_s1 NM_024807 TREML2 Hs01077557_m1 D16845 TRHR Hs00175019_m1 AF220123 TRIM10 Hs00232497_m1 NM_006458 TRIM3 Hs00197678_m1 NM_007118 TRIO Hs00179276_m1 NM_024971 TRPM3 Hs00326297_m1 NM_001010873 TSPO2 Hs00416836_m1 NM_017931 TTC38 Hs00215654_m1 NR_001536 TTTY2 Hs00287662_m1 U82467 TUB Hs00163231_m1 NM_003320 TUB Hs00163231_m1 NM_025218 ULBP1 Hs00360941_m1 NM_004205 USP2 Hs00899199_g1 NM_015023 WDTC1 Hs00248234_m1 NM_003393 WNT8B Hs00610126_m1 NM_181710 ZNRF4 Hs00741333_s1 NM_015113 ZZEF1 Hs00209409_m1 54 ASPN Número de acceso (GenBank) Símbolo del gen TaqMan®Assay (extremo 3') NM_001613 ACTA2 Hs00426835_g1 NM_001102 ACTN1 Hs00998100_m1 NM_001105 ACVR1 Hs00153836_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_139056 ADAMTS16 Hs01049997_m1 NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_197941 ADAMTS6 Hs00812159_s1 AF284095 ADRA2A Hs00265081_s1 NM_001129 AEBP1 Hs00937468_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_005465 AKT3 Hs00289302_s1 NM_001034173 ALDH1L2 Hs00402876_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_054027 ANKH Hs00219798_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_004308 ARHGAP1 Hs00188815_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_018071 ARHGEF40 Hs00216283_m1 AF316824 ASPN Hs00214395_m1 NM_024490 ATP10A Hs00257114_m1 NM_000332 ATXN1 Hs00165656_m1 NM_021913 AXL Hs01064444_m1 NM_012104 BACE1 Hs01123242_m1 NM_152731 BEND6 Hs00288163_m1 NM_001711 BGN Hs00959143_m1 NM_001711 BGN Hs00959143_m1 BC002416 BGN Hs00959143_m1 NM_017614 BHMT2 Hs00214120_m1 NM_006129 BMP1 Hs00196183_m1 NM_001199 BMP1 Hs00986789_m1 NM_001204 BMPR2 Hs00176148_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017787 C10orf26 Hs00740771_s1 NM_030945 C1QTNF3 Hs00229569_m1 AF329841 C1QTNF5 Hs00363053_g1 NM_031910 C1QTNF6 Hs00230464_m1 AF329842 C1QTNF6 Hs00230464_m1 NM_031911 C1QTNF7 Hs00230467_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 NM_004772 C5orf13 Hs00854282_g1 NM_004772 C5orf13 Hs00854282_g1 NM_001007189 C5orf53 Hs00759532_s1 AF313413 C5orf62 Hs00383944_m1 NM_032823 C9orf3 Hs01051467_m1 NM_000722 CACNA2D1 Hs00984856_m1 NM_014333 CADM1 Hs00296064_s1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_001753 CAV1 Hs00971716_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_016557 CCRL1 Hs00664347_s1 NM_020404 CD248 Hs00535586_s1 NM_000574 CD55 Hs00167090_m1 BC001288 CD55 Hs00167090_m1 NM_012072 CD93 Hs00362607_m1 U82164 CD99 Hs00242853_m1 NM_002414 CD99 Hs00365982_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 56 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_004936 CDKN2B Hs00793225_m1 NM_016174 CERCAM Hs00170969_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_175856 CHSY3 Hs00545664_m1 NM_003613 CILP Hs00173647_m1 D86586 CLEC11A Hs00161544_m1 NM_002975 CLEC11A Hs00161544_m1 BC005810 CLEC11A Hs00161544_m1 NM_024769 CLMP Hs00956750_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 NM_004368 CNN2 Hs00854264_s1 NM_015463 CNRIP1 Hs00384403_m1 NM_000493 COL10A1 Hs00166657_m1 NM_000493 COL10A1 Hs00166657_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 NM_001856 COL16A1 Hs00156876_m1 NM_030582 COL18A1 Hs01043425_g1 AF018081 COL18A1 Hs01043425_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 NM_000393 COL5A2 Hs00893923_m1 NM_015719 COL5A3 Hs00210526_m1 57 NM_015719 COL5A3 Hs00210526_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001849 COL6A2 Hs00242484_m1 AY029208 COL6A2 Hs00242484_m1 NM_004369 COL6A3 Hs00915120_m1 NM_001850 COL8A1 Hs00156669_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_000095 COMP Hs00164359_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_001864 COX7A1 Hs00156989_m1 NM_019609 CPXM1 Hs01566704_g1 BC006393 CPZ Hs00186333_m1 AL136861 CRISPLD2 Hs00230322_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_138455 CTHRC1 Hs00298917_m1 NM_000396 CTSK Hs00166156_m1 NM_000609 CXCL12 Hs00930455_m1 NM_020311 CXCR7 Hs00664172_s1 AL136693 CYBRD1 Hs00227411_m1 AF003114 CYR61 Hs00998503_g1 NM_001554 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_003737 DCHS1 Hs01044548_m1 NM_001920 DCN Hs00754870_s1 AF138303 DCN Hs00266491_m1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_001920 DCN Hs00754870_s1 NM_006182 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_000793 DIO2 Hs00255341_m1 58 NM_013989 DIO2 Hs00255341_m1 NM_014974 DIP2C Hs00324224_m1 NM_014974 DIP2C Hs00324224_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 AF026219 DLC1 Hs00931487_m1 NM_006094 DLC1 Hs00183436_m1 NM_001005336 DNM1 Hs00189369_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_013352 DSE Hs00203441_m1 NM_024007 EBF1 Hs00395513_m1 NM_001393 ECM2 Hs00154821_m1 NM_005711 EDIL3 Hs00174781_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_016938 EFEMP2 Hs00213545_m1 AB030655 EFEMP2 Hs00213545_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_020390 EIF5A2 Hs00702673_s1 NM_005230 ELK3 Hs00987814_m1 NM_000501 ELN Hs01091772_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_001008707 EML1 Hs00270014_m1 NM_004434 EML1 Hs00270014_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_004098 EMX2 Hs00244574_m1 NM_001776 ENTPD1 Hs00739960_s1 NM_004956 ETV1 Hs00290469_s1 NM_000129 F13A1 Hs00173388_m1 NM_001992 F2R Hs00169258_m1 NM_004101 F2RL2 Hs00187982_m1 NM_182705 FAM101B Hs00823804_m1 NM_182705 FAM101B Hs00823804_m1 AF260333 FAM198B Hs00259260_s1 NM_153711 FAM26E Hs00382139_m1 U76833 FAP Hs00990806_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 59 NM_006486 FBLN1 Hs00197774_m1 NM_001996 FBLN1 Hs00242546_m1 NM_001998 FBLN2 Hs00157482_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_006832 FERMT2 Hs01041255_m1 NM_006832 FERMT2 Hs01041255_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 NM_003862 FGF18 Hs00818572_m1 NM_001449 FHL1 Hs00793641_g1 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 NM_014890 FILIP1L Hs00706279_s1 NM_017946 FKBP14 Hs00942521_m1 NM_017946 FKBP14 Hs00942521_m1 AF100751 FKBP7 Hs00535040_m1 NM_007270 FKBP9 Hs00414859_m1 NM_013231 FLRT2 Hs00544171_s1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 BC005858 FN1 Hs00415006_m1 AF130095 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_032532 FNDC1 Hs00287359_m1 NM_005253 FOSL2 Hs00232013_m1 NM_001452 FOXF2 Hs00230963_m1 NM_152330 FRMD6 Hs00378563_m1 NM_152330 FRMD6 Hs00378563_m1 NM_013409 FST Hs00246256_m1 NM_006350 FST Hs00246260_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_003505 FZD1 Hs00268943_s1 NM_000813 GABRB2 Hs00289390_s1 NM_015675 GADD45B Hs00169587_m1 NM_020474 GALNT1 Hs00234919_m1 NM_020474 GALNT1 Hs00234919_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 L13720 GAS6 Hs01090305_m1 NM_000820 GAS6 Hs01090305_m1 BC001152 GAS7 Hs00932959_m1 NM_003644 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005110 GFPT2 Hs01049561_m1 NM_000165 GJA1 Hs00748445_s1 NM_005266 GJA5 Hs00270952_s1 M86849 GJB2 Hs00269615_s1 NM_005270 GLI2 Hs00257977_m1 NM_032575 GLIS2 Hs00402743_g1 NM_152629 GLIS3 Hs00295084_s1 NM_152629 GLIS3 Hs00295084_s1 NM_018446 GLT8D1 Hs00251197_m1 NM_018446 GLT8D1 Hs00251197_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_004126 GNG11 Hs00914578_m1 NM_018841 GNG12 Hs03005750_m1 NM_014498 GOLIM4 Hs00274320_m1 NM_005708 GPC6 Hs00170677_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_001008397 GPX8 Hs00380670_m1 AF154054 GREM1 Hs00171951_m1 NM_013372 GREM1 Hs00171951_m1 NM_002091 GRP Hs00181852_m1 NM_016315 GULP1 Hs00169604_m1 AF200715 GULP1 Hs00169604_m1 NR_002196 H19 Hs00262142_g1 NR_002196 H19 Hs00262142_g1 NM_014799 HEPH Hs00953259_m1 NM_014571 HEYL Hs01113778_m1 NM_031935 HMCN1 Hs00399043_m1 NM_006895 HNMT Hs00199373_m1 NM_001024074 HNMT Hs02759756_s1 NM_003725 HSD17B6 Hs00366258_m1 NM_003725 HSD17B6 Hs00366258_m1 NM_052970 HSPA12B Hs00369554_m1 M85289 HSPG2 Hs01078536_m1 NM_002775 HTRA1 Hs01016151_m1 NM_053044 HTRA3 Hs01099710_m1 226944_at NM_053044 HTRA3 209721_s_at BC002857 IFFO1 61 227870_at NM_020962 IGDCC4 209540_at NM_000618 IGF1 209541_at NM_000618 IGF1 202409_at NM_001007139 IGF2 201508_at NM_001552 IGFBP4 201163_s_at NM_001553 IGFBP7 201162_at NM_001553 IGFBP7 202948_at NM_000877 IL1R1 210511_s_at M13436 INHBA 227140_at NM_002192 INHBA 207191_s_at NM_005545 ISLR 222899_at AF109681 ITGA11 201389_at NM_002205 ITGA5 202351_at NM_002210 ITGAV 211945_s_at NM_002211 ITGB1 214021_x_at NM_002213 ITGB5 214020_x_at NM_002213 ITGB5 201124_at NM_002213 ITGB5 201125_s_at NM_002213 ITGB5 214927_at NM_004791 ITGBL1 205422_s_at NM_004791 ITGBL1 209298_s_at AF114488 ITSN1 35776_at NM_001001132 ITSN1 209297_at AF114488 ITSN1 219213_at NM_021219 JAM2 212813_at NM_032801 JAM3 218418_s_at NM_015493 KANK2 229125_at NM_181712 KANK4 222857_s_at AF160967 KCNMB4 219479_at NM_024089 KDELC1 220504_at NM_007035 KERA 212942_s_at NM_018689 KIAA1199 231807_at NM_019590 KIAA1217 220002_at NM_018012 KIF26B 225303_at NM_018240 KIRREL 202393_s_at NM_005655 KLF10 205116_at NM_000426 LAMA2 216840_s_at NM_000426 LAMA2 213519_s_at NM_000426 LAMA2 202202_s_at NM_002290 LAMA4 211651_s_at M20206 LAMB1 201505_at NM_002291 LAMB1 200771_at NM_002293 LAMC1 223380_s_at AF207547 LATS2 227013_at NM_014572 LATS2 62 228080_at NM_178834 LAYN 206481_s_at NM_001290 LDB2 202377_at NM_001003679 LEPR 220750_s_at NM_022356 LEPRE1 201105_at NM_002305 LGALS1 231411_at NM_005780 LHFP 218656_s_at NM_005780 LHFP 230708_at NM_199000 LHFPL3 217892_s_at NM_016357 LIMA1 218574_s_at NM_014583 LMCD1 203766_s_at NM_012134 LMOD1 204298_s_at NM_002317 LOX 215446_s_at NM_002317 LOX 203570_at NM_005576 LOXL1 202998_s_at NM_002318 LOXL2 204037_at NM_001401 LPAR1 204036_at NM_001401 LPAR1 227688_at NM_020871 LRCH2 200784_s_at NM_002332 LRP1 200785_s_at NM_002332 LRP1 213909_at NM_130830 LRRC15 205381_at NM_005824 LRRC17 203835_at NM_005512 LRRC32 226826_at NM_173491 LSM11 223690_at AF113211 LTBP2 204682_at NM_000428 LTBP2 201744_s_at NM_002345 LUM 229554_at NM_002345 LUM 218559_s_at NM_005461 MAFB 219894_at NM_019066 MAGEL2 203151_at NM_002373 MAP1A 203552_at NM_006575 MAP4K5 223095_at BC004995 MARVELD1 206091_at NM_002381 MATN3 203417_at NM_017459 MFAP2 212713_at NM_002404 MFAP4 209758_s_at U37283 MFAP5 213765_at NM_003480 MFAP5 213764_s_at NM_003480 MFAP5 212472_at NM_014632 MICAL2 212473_s_at NM_014632 MICAL2 207233_s_at NM_000248 MITF 226066_at NM_000248 MITF 203876_s_at NM_005940 MMP11 203878_s_at NM_005940 MMP11 63 205959_at NM_002427 MMP13 202827_s_at NM_004995 MMP14 160020_at NM_004995 MMP14 202828_s_at NM_004995 MMP14 223614_at AL136588 MMP16 204575_s_at U38321 MMP19 201069_at NM_004530 MMP2 205330_at NM_002430 MN1 37408_at NM_006039 MRC2 227727_at NM_145015 MRGPRF 238583_at NM_001031679 MSRB3 225790_at NM_001031679 MSRB3 225782_at NM_001031679 MSRB3 209596_at AF245505 MXRA5 212509_s_at NM_001008528 MXRA7 227326_at NM_001008528 MXRA7 213422_s_at NM_032348 MXRA8 201058_s_at NM_006097 MYL9 201798_s_at NM_013451 MYOF 228608_at NM_052867 NALCN 204749_at NM_004538 NAP1L3 201621_at NM_005380 NBL1 37005_at NM_005380 NBL1 209550_at U35139 NDN 213012_at NM_006154 NEDD4 243357_at NM_173808 NEGR1 229461_x_at NM_173808 NEGR1 226103_at NM_144573 NEXN 202008_s_at NM_002508 NID1 202007_at NM_002508 NID1 204114_at NM_007361 NID2 219594_at NM_016533 NINJ2 232201_at NM_033120 NKD2 207031_at NM_001189 NKX3-2 202238_s_at NM_006169 NNMT 202237_at NM_006169 NNMT 219773_at NM_016931 NOX4 212298_at NM_001024628 NRP1 222877_at NM_003872 NRP2 229225_at NM_003872 NRP2 225566_at NM_003872 NRP2 227486_at NM_002526 NT5E 222020_s_at NM_016522 NTM 227566_at NM_016522 NTM 223315_at AF278532 NTN4 64 204589_at NM_014840 NUAK1 228141_at NM_019094 NUDT4 218730_s_at NM_014057 OGN 222722_at NM_014057 OGN 217525_at NM_198474 OLFML1 213125_at NM_015441 OLFML2B 218162_at NM_020190 OLFML3 205908_s_at NM_005014 OMD 205907_s_at NM_005014 OMD 228703_at NM_182904 P4HA3 200906_s_at NM_016081 PALLD 200907_s_at NM_016081 PALLD 200897_s_at NM_016081 PALLD 212958_x_at NM_000919 PAM 222455_s_at AF237771 PARVA 217890_s_at NM_018222 PARVA 225975_at NM_019035 PCDH18 210273_at AB006757 PCDH7 228640_at NM_002589 PCDH7 202465_at NM_002593 PCOLCE 205560_at NM_006200 PCSK5 205559_s_at NM_006200 PCSK5 213652_at NM_006200 PCSK5 236300_at NM_000921 PDE3A 218718_at NM_016205 PDGFC 219304_s_at NM_025208 PDGFD 203131_at NM_006206 PDGFRA 202273_at NM_002609 PDGFRB 205226_at NM_006207 PDGFRL 219165_at NM_021630 PDLIM2 203370_s_at NM_005451 PDLIM7 226658_at NM_001006624 PDPN 204879_at NM_006474 PDPN 221898_at NM_001006624 PDPN 212915_at NM_015009 PDZRN3 212134_at NM_015157 PHLDB1 203688_at NM_000297 PKD2 235746_s_at NM_001007267 PLA2R1 227419_x_at NM_001012973 PLAC9 211668_s_at K03226 PLAU 205479_s_at NM_002658 PLAU 204940_at NM_002667 PLN 204939_s_at NM_002667 PLN 201215_at NM_005032 PLS3 218901_at NM_020353 PLSCR4 219700_at NM_020405 PLXDC1 227276_at NM_032812 PLXDC2 213241_at NM_005761 PLXNC1 222449_at NM_020182 PMEPA1 222450_at NM_020182 PMEPA1 210139_s_at L03203 PMP22 226522_at NM_153703 PODN 214981_at NM_006475 POSTN 210809_s_at D13665 POSTN 236044_at NM_001030059 PPAPDC1A 203735_x_at NM_003622 PPFIBP1 204518_s_at NM_000943 PPIC 204517_at NM_000943 PPIC 230311_s_at AF272898 PRDM6 226065_at NM_153026 PRICKLE1 226069_at NM_153026 PRICKLE1 225968_at NM_198859 PRICKLE2 213010_at NM_145040 PRKCDBP 205880_at NM_002742 PRKD1 219383_at NM_024841 PRR5L 238852_at NM_006902 PRRX1 205991_s_at NM_006902 PRRX1 226695_at NM_006902 PRRX1 224937_at NM_020440 PTGFRN 226380_at NM_007039 PTPN21 213362_at NM_002839 PTPRD 214043_at NM_002839 PTPRD 204944_at NM_002841 PTPRG 227126_at NM_002841 PTPRG 208790_s_at AF312393 PTRF 208789_at NM_012232 PTRF 223463_at AF161486 RAB23 229504_at NM_016277 RAB23 217763_s_at NM_006868 RAB31 217764_s_at AF183421 RAB31 217762_s_at NM_006868 RAB31 202052_s_at NM_015577 RAI14 209496_at BC000069 RARRES2 228109_at NM_006909 RASGRF2 206767_at NM_014483 RBMS3 203498_at NM_005822 RCAN2 204759_at NM_001268 RCBTB2 219102_at NM_020650 RCN3 61734_at NM_020650 RCN3 205407_at NM_021111 RECK 66 219489_s_at NM_017821 RHBDL2 209684_at AL136924 RIN2 204040_at NM_014746 RNF144A 205578_at NM_004560 ROR2 212912_at NM_001006932 RPS6KA2 209360_s_at D43968 RUNX1 205528_s_at NM_004349 RUNX1T1 205529_s_at NM_004349 RUNX1T1 228827_at NM_004349 RUNX1T1 236859_at NM_001015051 RUNX2 232231_at NM_001015051 RUNX2 206893_at NM_002968 SALL1 229273_at NM_002968 SALL1 227557_at NM_153334 SCARF2 201286_at NM_001006946 SDC1 212887_at NM_006364 SEC23A 200945_s_at NM_014933 SEC31A 214293_at NM_018243 SEPT11 230071_at NM_018243 SEPT11 201307_at NM_018243 SEPT11 202283_at NM_002615 SERPINF1 200986_at NM_000062 SERPING1 223121_s_at NM_003013 SFRP2 223122_s_at AF311912 SFRP2 204052_s_at NM_003014 SFRP4 204051_s_at NM_003014 SFRP4 214492_at NM_000337 SGCD 228602_at NM_000337 SGCD 230730_at NM_000337 SGCD 213543_at NM_000337 SGCD 241872_at NM_032291 SGIP1 223672_at AL136561 SGIP1 227038_at NM_152621 SGMS2 225162_at NM_001009555 SH3D19 213252_at NM_014631 SH3PXD2A 224817_at NM_014631 SH3PXD2A 231823_s_at NM_001017995 SH3PXD2B 208443_x_at NM_006884 SHOX2 210135_s_at AF022654 SHOX2 230130_at NM_004787 SLIT2 209897_s_at AF055585 SLIT2 203813_s_at NM_003062 SLIT3 230218_at NM_017575 SMG6 223235_s_at AB014737 SMOC2 213139_at NM_003068 SNAI2 67 228720_at NM_020777 SORCS2 212667_at NM_003118 SPARC 200665_s_at NM_003118 SPARC 200795_at NM_004684 SPARCL1 222154_s_at NM_015535 SPATS2L 202363_at AF231124 SPOCK1 209437_s_at AB051390 SPON1 213993_at NM_006108 SPON1 209436_at NM_006108 SPON1 213994_s_at NM_006108 SPON1 218638_s_at NM_012445 SPON2 219677_at NM_025106 SPSB1 226075_at NM_025106 SPSB1 204955_at NM_006307 SRPX 205499_at NM_014467 SRPX2 204963_at AL136756 SSPN 226932_at NM_005086 SSPN 202440_s_at NM_005418 ST5 228821_at NM_032528 ST6GAL2 213103_at NM_052851 STARD13 212344_at NM_015170 SULF1 212354_at NM_015170 SULF1 212353_at NM_015170 SULF1 233555_s_at NM_018837 SULF2 224724_at NM_018837 SULF2 44702_at NM_033025 SYDE1 221276_s_at NM_030786 SYNC 219310_at NM_024893 SYNDIG1 202796_at NM_007286 SYNPO 242340_at NM_005639 SYT1 229991_s_at NM_080737 SYTL4 205547_s_at NM_003186 TAGLN 215464_s_at NM_014604 TAX1BP3 209154_at AF234997 TAX1BP3 230438_at NM_152380 TBX15 240715_at NM_000192 TBX5 227705_at NM_152278 TCEAL7 208986_at NM_003205 TCF12 238041_at NM_003205 TCF12 212382_at NM_003199 TCF4 228837_at NM_003199 TCF4 212385_at NM_003199 TCF4 203753_at NM_003199 TCF4 222146_s_at NM_003199 TCF4 212386_at NM_003199 TCF4 68 213891_s_at NM_003199 TCF4 224955_at NM_021961 TEAD1 209651_at BC001830 TGFB1I1 209747_at J03241 TGFB3 203083_at NM_003247 THBS2 204776_at NM_003248 THBS4 208850_s_at NM_006288 THY1 213869_x_at NM_006288 THY1 208851_s_at AL161958 THY1 224560_at NM_003255 TIMP2 231579_s_at NM_003255 TIMP2 201149_s_at U67195 TIMP3 201148_s_at NM_000362 TIMP3 201147_s_at NM_000362 TIMP3 201150_s_at NM_000362 TIMP3 202011_at NM_003257 TJP1 219315_s_at NM_024600 TMEM204 206026_s_at NM_007115 TNFAIP6 206025_s_at NM_007115 TNFAIP6 227812_at NM_018647 TNFRSF19 221748_s_at NM_022648 TNS1 217853_at NM_022748 TNS3 204083_s_at NM_003289 TPM2 215382_x_at NM_003294 TPSAB1 216474_x_at NM_003294 TPSAB1 205683_x_at NM_003294 TPSAB1 207134_x_at NM_024164 TPSB2 204140_at NM_003596 TPST1 202369_s_at NM_012288 TRAM2 205802_at NM_003304 TRPC1 205803_s_at NM_003304 TRPC1 223392_s_at NM_020856 TSHZ3 223393_s_at AL136805 TSHZ3 225406_at NM_020648 TWSG1 223279_s_at AF322916 UACA 201535_at NM_007106 UBL3 224827_at NM_152277 UBTD2 41856_at NM_170744 UNC5B 213100_at NM_170744 UNC5B 226899_at NM_170744 UNC5B 211571_s_at D32039 VCAN 215646_s_at NM_004385 VCAN 204620_s_at NM_004385 VCAN 221731_x_at NM_004385 VCAN 204619_s_at NM_004385 VCAN 69 200931_s_at NM_014000 VCL 227399_at NM_016206 VGLL3 201426_s_at NM_003380 VIM 235471_at NM_001031746 VSTM4 213381_at NM_001031746 VSTM4 206796_at NM_003882 WISP1 235821_at NM_003882 WISP1 229802_at NM_003882 WISP1 205792_at NM_003881 WISP2 205648_at NM_003391 WNT2 213425_at NM_003392 WNT5A 205990_s_at NM_003392 WNT5A 202133_at NM_015472 WWTR1 224894_at NM_006106 YAP1 226484_at NM_145166 ZBTB47 212419_at NM_153367 ZCCHC24 212423_at NM_153367 ZCCHC24 212758_s_at NM_030751 ZEB1 210875_s_at U12170 ZEB1 241700_at NM_024721 ZFHX4 219779_at NM_024721 ZFHX4 219778_at NM_012082 ZFPM2 214761_at NM_015069 ZNF423 226677_at NM_015461 ZNF521 226676_at NM_015461 ZNF521 225021_at NM_018181 ZNF532 AZGP1 Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') AF237813 ABAT Hs00252934_s1 AF237813 ABAT Hs00252934_s1 NM_001627 ALCAM Hs00977639_m1 NM_004673 ANGPTL1 Hs00559786_m1 M73069 AR Hs00907244_m1 AF162704 AR Hs00907244_m1 NM_005603 ATP8B1 Hs00900656_m1 NM_001185 AZGP1 Hs00426651_m1 NM_025057 C14orf45 Hs00228117_m1 NM_030806 C1orf21 Hs00229347_m1 NM_030806 C1orf21 Hs00229347_m1 NM_030806 C1orf21 Hs00229347_m1 NM_152400 C4orf32 Hs03043968_m1 NM_174921 C4orf34 Hs01595303_m1 NM_001012993 C9orf152 Hs00418117_m1 NM_001218 CA12 Hs00250312_s1 NM_001218 CA12 Hs00250312_s1 NM_001218 CA12 Hs00250312_s1 NM_001280 CIRBP Hs00989762_g1 NM_001280 CIRBP Hs00989762_g1 NM_130898 CREB3L4 Hs00370116_m1 NM_001914 CYB5A Hs04229876_g1 M22865 CYB5A Hs04229876_g1 NM_001914 CYB5A Hs04229876_g1 NM_144611 CYB5D2 Hs00376067_m1 NM_178033 CYP4X1 Hs00380077_m1 NM_014762 DHCR24 Hs00207388_m1 NM_003732 EIF4EBP3 Hs00358624_g1 AL136939 ELOVL5 Hs01094711_m1 NM_001249 ENTPD5 Hs04176260_g1 AF233336 EPHX2 Hs00157403_m1 NM_001982 ERBB3 Hs00951456_g1 NM_000125 ESR1 Hs01046818_m1 NM_145235 FANK1 Hs01113524_m1 NM_001461 FMO5 Hs00356233_m1 NM_004496 FOXA1 Hs00270129_m1 NM_017423 GALNT7 Hs00213624_m1 NM_017423 GALNT7 Hs00213624_m1 NM_001033044 GLUL Hs01013056_g1 NM_015141 GPD1L Hs00380515_m1 NM_020153 IFT46 Hs00375293_m1 NM_015015 KDM4B Hs00943636_m1 NM_015015 KDM4B Hs00943636_m1 NM_020775 KIAA1324 Hs00331399_m1 NM_020775 KIAA1324 Hs00331399_m1 NM_019600 KIAA1370 Hs00325311_m1 NM_015254 KIF13B Hs00209573_m1 NM_014988 LIMCH1 Hs00405524_m1 NM_014988 LIMCH1 Hs00405524_m1 AB050468 LRIG1 Hs00394267_m1 AF126181 MAGED2 Hs00374760_m1 NM_005910 MAPT Hs00326720_s1 J03778 MAPT Hs00902194_m1 NM_005910 MAPT Hs00326720_s1 NM_005910 MAPT Hs00326720_s1 NM_024101 MLPH Hs00225445_m1 NM_024101 MLPH Hs00225445_m1 NM_022100 MRPS14 Hs00223099_m1 NM_001001924 MTUS1 Hs00826834_m1 NM_005375 MYB Hs00193527_m1 71 NM_018728 MYO5C Hs00218921_m1 NM_000662 NAT1 Hs00265080_s1 NM_052946 NOSTRIN Hs00976555_m1 NM_015392 NPDC1 Hs00209870_m1 NM_002652 PIP Hs01114172_m1 AF225513 PKIB Hs00261162_m1 NM_022449 RAB17 Hs00940833_m1 NM_004703 RABEP1 Hs00388983_m1 NM_004703 RABEP1 Hs00388983_m1 NM_002937 RNASE4 Hs00268002_s1 NM_002937 RNASE4 Hs00268002_s1 NM_001001523 RORC Hs01076112_m1 NM_173079 RUNDC1 Hs00405433_m1 NM_173079 RUNDC1 Hs00405433_m1 NM_001038 SCNN1A Hs00168906_m1 NM_020974 SCUBE2 Hs00221277_m1 NM_012429 SEC14L2 Hs00202756_m1 NM_012429 SEC14L2 Hs00202756_m1 NM_003944 SELENBP1 Hs00187625_m1 NM_020859 SHROOM3 Hs00290214_m1 NM_020859 SHROOM3 Hs00290214_m1 AF303378 SIAE Hs00405144_m1 NM_003060 SLC22A5 Hs00929869_m1 NM_012319 SLC39A6 Hs00202392_m1 NM_025257 SLC44A4 Hs00228901_m1 NM_019073 SPATA6 Hs00219452_m1 NM_015130 TBC1D9 Hs00324085_m1 NM_024817 THSD4 Hs00388227_m1 NM_014428 TJP3 Hs00274276_m1 AF161526 TMBIM4 Hs00211390_m1 NM_003217 TMBIM6 Hs00162661_m1 NM_144686 TMC4 Hs00376274_m1 NM_018342 TMEM144 Hs00938021_m1 NM_032780 TMEM25 Hs00536347_m1 NM_198485 TPRG1 Hs00415626_m1 NM_005080 XBP1 Hs00231936_m1 NM_145252 ZG16B Hs00377054_m1 BGN Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_005157 ABL1 Hs01104721_m1 NM_001613 ACTA2 Hs00426835_g1 NM_001101 ACTB Hs03023880_g1 M95178 ACTN1 Hs00998100_m1 72 BC003576 ACTN1 Hs00998100_m1 NM_001102 ACTN1 Hs00998100_m1 NM_000020 ACVRL1 Hs00163543_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_139056 ADAMTS16 Hs01049997_m1 NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_197941 ADAMTS6 Hs00812159_s1 NM_052998 ADC Hs00364871_m1 NM_001129 AEBP1 Hs00937468_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_006738 AKAP13 Hs00331658_s1 NM_006738 AKAP13 Hs00331658_s1 NM_005465 AKT3 Hs00289302_s1 NM_001034173 ALDH1L2 Hs00402876_m1 NM_130847 AMOTL1 Hs00294070_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_054027 ANKH Hs00219798_m1 NM_054027 ANKH Hs00219798_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_004308 ARHGAP1 Hs00188815_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_000047 ARSE Hs01033722_m1 AF316824 ASPN Hs00214395_m1 NM_017680 ASPN Hs00214395_m1 NM_001007026 ATN1 Hs00157312_m1 NM_000332 ATXN1 Hs00165656_m1 NM_001699 AXL Hs01064444_m1 73 NM_021913 AXL Hs01064444_m1 NM_012104 BACE1 Hs01123242_m1 NM_181844 BCL6B Hs00394655_m1 NM_001711 BGN Hs00959143_m1 BC002416 BGN Hs00959143_m1 NM_017614 BHMT2 Hs00214120_m1 NM_017614 BHMT2 Hs00214120_m1 NM_001199 BMP1 Hs00986789_m1 NM_006129 BMP1 Hs00196183_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_030968 C1QTNF1 Hs00945123_m1 NM_030945 C1QTNF3 Hs00229569_m1 AF329841 C1QTNF5 Hs00363053_g1 AF329842 C1QTNF6 Hs00230464_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 NM_004772 C5orf13 Hs00854282_g1 AF313413 C5orf62 Hs00383944_m1 NM_183373 C6orf145 Hs00406043_m1 NM_024728 C7orf10 Hs00257329_m1 NM_032823 C9orf3 Hs01051467_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_032040 CCDC8 Hs00540204_s1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_025140 CCDC92 Hs00228468_m1 NM_020404 CD248 Hs00535586_s1 NM_001024736 CD276 Hs00987207_m1 NM_012072 CD93 Hs00362607_m1 NM_002414 CD99 Hs00365982_m1 U82164 CD99 Hs00242853_m1 NM_002414 CD99 Hs00365982_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 74 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_004936 CDKN2B Hs00793225_m1 NM_016174 CERCAM Hs00170969_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_024536 CHPF Hs00226041_m1 NM_018413 CHST11 Hs00218229_m1 NM_175856 CHSY3 Hs00545664_m1 NM_003613 CILP Hs00173647_m1 D86586 CLEC11A Hs00161544_m1 NM_002975 CLEC11A Hs00161544_m1 BC005810 CLEC11A Hs00161544_m1 NM_015526 CLIP3 Hs00367493_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 NM_004368 CNN2 Hs00854264_s1 NM_015463 CNRIP1 Hs00384403_m1 NM_000493 COL10A1 Hs00166657_m1 NM_000493 COL10A1 Hs00166657_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 NM_001856 COL16A1 Hs00156876_m1 AF018081 COL18A1 Hs01043425_g1 NM_030582 COL18A1 Hs01043425_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_001846 COL4A2 Hs01098873_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 75 NM_000393 COL5A2 Hs00893923_m1 NM_015719 COL5A3 Hs00210526_m1 NM_015719 COL5A3 Hs00210526_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001849 COL6A2 Hs00242484_m1 AY029208 COL6A2 Hs00242484_m1 NM_004369 COL6A3 Hs00915120_m1 NM_001850 COL8A1 Hs00156669_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_000095 COMP Hs00164359_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_001864 COX7A1 Hs00156989_m1 NM_019609 CPXM1 Hs01566704_g1 BC006393 CPZ Hs00186333_m1 AL136861 CRISPLD2 Hs00230322_m1 NM_014460 CSDC2 Hs00411093_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_138455 CTHRC1 Hs00298917_m1 NM_014772 CTIF Hs00207460_m1 NM_001908 CTSB Hs00947439_m1 NM_000396 CTSK Hs00166156_m1 NM_000609 CXCL12 Hs00930455_m1 NM_000398 CYB5R3 Hs00240921_m1 NM_134268 CYGB Hs00370478_m1 AF003114 CYR61 Hs00998503_g1 NM_001554 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 BC003064 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_003737 DCHS1 Hs01044548_m1 AF138303 DCN Hs00266491_m1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_001920 DCN Hs00754870_s1 76 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_006182 DDR2 Hs01025953_m1 NM_014974 DIP2C Hs00324224_m1 NM_014974 DIP2C Hs00324224_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 NM_006094 DLC1 Hs00183436_m1 AF026219 DLC1 Hs00931487_m1 NM_001005336 DNM1 Hs00189369_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_013352 DSE Hs00203441_m1 NM_014934 DZIP1 Hs00208790_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_001393 ECM2 Hs00154821_m1 NM_005711 EDIL3 Hs00174781_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_016938 EFEMP2 Hs00213545_m1 AB030655 EFEMP2 Hs00213545_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_000501 ELN Hs01091772_m1 NM_000501 ELN Hs01091772_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_004098 EMX2 Hs00244574_m1 NM_000118 ENG Hs03986114_s1 NM_138961 ESAM Hs00332781_m1 NM_004956 ETV1 Hs00290469_s1 NM_147127 EVC2 Hs00377633_m1 NM_000129 F13A1 Hs00173388_m1 NM_001992 F2R Hs00169258_m1 NM_004101 F2RL2 Hs00187982_m1 NM_182705 FAM101B Hs00823804_m1 NM_182705 FAM101B Hs00823804_m1 NM_020223 FAM20C Hs00398243_m1 NM_153711 FAM26E Hs00382139_m1 U76833 FAP Hs00990806_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 77 NM_006486 FBLN1 Hs00197774_m1 NM_001996 FBLN1 Hs00242546_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_006832 FERMT2 Hs01041255_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 NM_003862 FGF18 Hs00818572_m1 BC006245 FGF18 Hs00818572_m1 NM_003862 FGF18 Hs00818572_m1 NM_001449 FHL1 Hs00793641_g1 NM_004468 FHL3 Hs00189516_m1 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 NM_014890 FILIP1L Hs00706279_s1 AF100751 FKBP7 Hs00535040_m1 NM_007270 FKBP9 Hs00414859_m1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_001458 FLNC Hs00155124_m1 AF169676 FLRT2 Hs00544171_s1 NM_013231 FLRT2 Hs00544171_s1 NM_175736 FMNL3 Hs00604672_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 AF130095 FN1 Hs00415006_m1 BC005858 FN1 Hs00415006_m1 NM_032532 FNDC1 Hs00287359_m1 NM_005253 FOSL2 Hs00232013_m1 NM_001452 FOXF2 Hs00230963_m1 NM_005197 FOXN3 Hs00830558_g1 NM_002015 FOXO1 Hs00231106_m1 NM_004118 FOXS1 Hs02379646_s1 NM_003088 FSCN1 Hs00979631_g1 NM_006350 FST Hs00246260_m1 NM_013409 FST Hs00246256_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 78 NM_000148 FUT1 Hs00355741_m1 NM_024637 GAL3ST4 Hs00430693_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 NM_000820 GAS6 Hs01090305_m1 L13720 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 NM_003644 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005110 GFPT2 Hs01049561_m1 NM_004121 GGT5 Hs00269779_m1 NM_005266 GJA5 Hs00270952_s1 M86849 GJB2 Hs00269615_s1 NM_005270 GLI2 Hs00257977_m1 NM_032575 GLIS2 Hs00402743_g1 NM_152629 GLIS3 Hs00295084_s1 NM_152629 GLIS3 Hs00295084_s1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_005708 GPC6 Hs00170677_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_207370 GPR153 Hs01112674_m1 NM_207370 GPR153 Hs01112674_m1 NM_015696 GPX7 Hs00210410_m1 NM_001008397 GPX8 Hs00380670_m1 AF154054 GREM1 Hs00171951_m1 NM_013372 GREM1 Hs00171951_m1 NM_002091 GRP Hs00181852_m1 NM_000177 GSN Hs00388617_m1 NR_002196 H19 Hs00262142_g1 NR_002196 H19 Hs00262142_g1 NM_014799 HEPH Hs00953259_m1 NM_014571 HEYL Hs01113778_m1 NM_031935 HMCN1 Hs00399043_m1 NM_003725 HSD17B6 Hs00366258_m1 NM_003725 HSD17B6 Hs00366258_m1 NM_052970 HSPA12B Hs00369554_m1 NM_005529 HSPG2 Hs01078536_m1 M85289 HSPG2 Hs01078536_m1 NM_002775 HTRA1 Hs01016151_m1 NM_053044 HTRA3 Hs01099710_m1 NM_053044 HTRA3 Hs01099710_m1 79 NM_002167 ID3 Hs00171409_m1 BC002857 IFFO1 Hs00209967_m1 NM_020962 IGDCC4 Hs00326335_m1 NM_000612 IGF2 Hs00277496_s1 NM_001007139 IGF2 Hs00277496_s1 M31159 IGFBP3 Hs00181211_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_004517 ILK Hs00177914_m1 NM_002192 INHBA Hs01081598_m1 M13436 INHBA Hs01081598_m1 NM_005545 ISLR Hs01921558_s1 AF109681 ITGA11 Hs01012939_m1 NM_002205 ITGA5 Hs01547673_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_015493 KANK2 Hs00795260_m1 NM_181712 KANK4 Hs00400916_m1 AF160967 KCNMB4 Hs00205704_m1 NM_024089 KDELC1 Hs00607574_g1 NM_018689 KIAA1199 Hs00378530_m1 NM_019590 KIAA1217 Hs00289569_m1 NM_018012 KIF26B Hs00215977_m1 NM_018240 KIRREL Hs00217307_m1 NM_003709 KLF7 Hs00748636_s1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002290 LAMA4 Hs00935293_m1 M20206 LAMB1 Hs01055971_m1 NM_002291 LAMB1 Hs01055971_m1 NM_002293 LAMC1 Hs00267056_m1 AF207547 LATS2 Hs00324396_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_000229 LCAT Hs01068069_m1 NM_022356 LEPRE1 Hs00223565_m1 NM_014262 LEPREL2 Hs00204607_m1 80 NM_002305 LGALS1 Hs00355202_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_199000 LHFPL3 Hs01585188_s1 NM_017980 LIMS2 Hs01002880_gH NM_153713 LIX1L Hs00542269_m1 NM_014583 LMCD1 Hs00205871_m1 NM_005572 LMNA Hs01108898_g1 NM_012134 LMOD1 Hs00201704_m1 NM_002317 LOX Hs00942480_m1 NM_002317 LOX Hs00942480_m1 NM_005576 LOXL1 Hs00935937_m1 NM_002318 LOXL2 Hs00158757_m1 NM_020871 LRCH2 Hs00325819_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_130830 LRRC15 Hs00370056_s1 NM_005824 LRRC17 Hs00180581_m1 NM_005512 LRRC32 Hs00194136_m1 AF113211 LTBP2 Hs00544640_s1 NM_000428 LTBP2 Hs00544640_s1 NM_002345 LUM Hs00158940_m1 NM_002345 LUM Hs00158940_m1 NM_033631 LUZP1 Hs00612276_m1 NM_021020 LZTS1 Hs00232762_m1 NM_005461 MAFB Hs00271378_s1 NM_019066 MAGEL2 Hs00255922_s1 NM_002373 MAP1A Hs00357973_m1 NM_002375 MAP4 Hs00159048_m1 M64571 MAP4 Hs00159048_m1 BC004995 MARVELD1 Hs00230362_m1 NM_002381 MATN3 Hs00159081_m1 NM_017459 MFAP2 Hs01027737_m1 NM_002404 MFAP4 Hs00412974_m1 U37283 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_014632 MICAL2 Hs01121806_m1 NM_014632 MICAL2 Hs01121806_m1 NM_000248 MITF Hs01117294_m1 NM_000248 MITF Hs01117294_m1 NM_005940 MMP11 Hs00171829_m1 NM_005940 MMP11 Hs00171829_m1 NM_002427 MMP13 Hs00942589_m1 NM_004995 MMP14 Hs01037009_g1 81 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 AL136588 MMP16 Hs00540314_s1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 NM_002430 MN1 Hs00159202_m1 NM_015134 MPRIP Hs00819388_m1 NM_015134 MPRIP Hs00819388_m1 NM_006039 MRC2 Hs00195862_m1 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 AF060154 MSC Hs00231955_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 AF245505 MXRA5 Hs00295630_s1 NM_001008528 MXRA7 Hs00895155_m1 NM_001008528 MXRA7 Hs00895155_m1 NM_032348 MXRA8 Hs00260584_m1 NM_002473 MYH9 Hs00159522_m1 NM_006097 MYL9 Hs00697086_m1 NM_015194 MYO1D Hs00381456_m1 NM_004998 MYO1E Hs00192232_m1 NM_052867 NALCN Hs00291166_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_005380 NBL1 Hs00185054_m1 NM_005380 NBL1 Hs00185054_m1 NM_006312 NCOR2 Hs00196955_m1 U35139 NDN Hs00267349_s1 NM_144573 NEXN Hs00332124_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_007361 NID2 Hs01547198_g1 NM_016533 NINJ2 Hs00356576_m1 NM_033120 NKD2 Hs00263909_m1 NM_001189 NKX3-2 Hs00154168_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_000435 NOTCH3 Hs01128541_m1 NM_016931 NOX4 Hs01558199_m1 NM_003995 NPR2 Hs00241516_m1 NM_016588 NRN1 Hs00213192_m1 AF145712 NRP1 Hs00826121_m1 NM_001024628 NRP1 Hs00826121_m1 82 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_002526 NT5E Hs01573922_m1 NM_016522 NTM Hs00275411_m1 NM_016522 NTM Hs00275411_m1 NM_014840 NUAK1 Hs00934234_m1 NM_019094 NUDT4 Hs00819603_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_015441 OLFML2B Hs00827139_g1 NM_020190 OLFML3 Hs00220180_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_182904 P4HA3 Hs00420085_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 AF237771 PARVA Hs00217177_m1 NM_018222 PARVA Hs00217177_m1 NM_016580 PCDH12 Hs00170986_m1 NM_019035 PCDH18 Hs00251855_m1 NM_002589 PCDH7 Hs00159908_m1 AB006757 PCDH7 Hs00361092_m1 AF152318 PCDHGA1 Hs00251717_m1 NM_002588 PCDHGC3 Hs00251717_m1 BC006439 PCDHGC3 Hs00251717_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_004716 PCSK7 Hs00237114_m1 NM_016205 PDGFC Hs00211916_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 NM_021630 PDLIM2 Hs00222154_m1 NM_005451 PDLIM7 Hs01103929_g1 NM_005451 PDLIM7 Hs01103929_g1 NM_006474 PDPN Hs01089982_g1 NM_001006624 PDPN Hs01089982_g1 NM_015157 PHLDB1 Hs00384827_m1 NM_000297 PKD2 Hs00165517_m1 NM_001012973 PLAC9 Hs00418288_m1 K03226 PLAU Hs00170182_m1 83 NM_002658 PLAU Hs00170182_m1 AY029180 PLAUR Hs00959822_m1 U08839 PLAUR Hs00182181_m1 NM_173542 PLBD2 Hs00381310_m1 NM_000445 PLEC Hs00356977_m1 NM_022835 PLEKHG2 Hs00293943_m1 NM_002667 PLN Hs00160179_m1 NM_005032 PLS3 Hs00192406_m1 NM_020360 PLSCR3 Hs00220521_m1 NM_020353 PLSCR4 Hs00924823_m1 AF326591 PLVAP Hs00229941_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_032812 PLXDC2 Hs00262350_m1 NM_005761 PLXNC1 Hs00955621_m1 NM_020182 PMEPA1 Hs03987603_g1 NM_020182 PMEPA1 Hs03987603_g1 NM_020182 PMEPA1 Hs03987603_g1 L03203 PMP22 Hs00165556_m1 NM_153703 PODN Hs00542259_m1 NM_000938 POLR2B Hs00265358_m1 NM_006475 POSTN Hs01566750_m1 D13665 POSTN Hs01566750_m1 NM_001030059 PPAPDC1A Hs00404185_m1 BC006362 PPAPDC3 Hs00262043_m1 NM_000943 PPIC Hs00181460_m1 NM_012231 PRDM2 Hs00202013_m1 AF272898 PRDM6 Hs01373000_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_145040 PRKCDBP Hs00293638_m1 NM_002742 PRKD1 Hs00177037_m1 NM_024841 PRR5L Hs00757785_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_016307 PRRX2 Hs00212537_m1 NM_020440 PTGFRN Hs01385989_m1 NM_002821 PTK7 Hs00897151_m1 NM_007039 PTPN21 Hs00234784_m1 NM_002839 PTPRD Hs00295441_s1 AF312393 PTRF Hs00396859_m1 84 NM_012232 PTRF Hs00396859_m1 AF161486 RAB23 Hs00212407_m1 AF183421 RAB31 Hs00199313_m1 NM_006868 RAB31 Hs00199313_m1 NM_006868 RAB31 Hs00199313_m1 NM_015577 RAI14 Hs00210238_m1 BC000069 RARRES2 Hs00161209_g1 NM_007368 RASA3 Hs00183698_m1 NM_004841 RASAL2 Hs00183129_m1 NM_006909 RASGRF2 Hs00394798_m1 NM_020650 RCN3 Hs00276633_m1 NM_020650 RCN3 Hs00276633_m1 NM_021111 RECK Hs01019179_m1 NM_021106 RGS3 Hs00367777_m1 NM_017821 RHBDL2 Hs00384848_m1 AL136924 RIN2 Hs00610937_m1 NM_014746 RNF144A Hs00207267_m1 NM_005012 ROR1 Hs00178178_m1 NM_001006932 RPS6KA2 Hs00179731_m1 D43968 RUNX1 Hs00231079_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001015051 RUNX2 Hs00298328_s1 NM_001015051 RUNX2 Hs00298328_s1 NM_002968 SALL1 Hs00231307_m1 NM_020436 SALL4 Hs00360675_m1 NM_153334 SCARF2 Hs00544847_m1 NM_001006946 SDC1 Hs00896425_g1 NM_014933 SEC31A Hs00274601_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_006216 SERPINE2 Hs00385730_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 AF311912 SFRP2 Hs00293258_m1 NM_003013 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 U58331 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 85 AL136561 SGIP1 Hs00260297_m1 NM_032291 SGIP1 Hs00260297_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_001017995 SH3PXD2B Hs00375183_s1 NM_006884 SHOX2 Hs01059691_m1 AF022654 SHOX2 Hs00243203_m1 NM_152264 SLC39A13 Hs00378317_m1 NM_003043 SLC6A6 Hs00896747_m1 NM_004787 SLIT2 Hs00191193_m1 AF055585 SLIT2 Hs00191193_m1 NM_003062 SLIT3 Hs00171524_m1 NM_005904 SMAD7 Hs00998193_m1 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 NM_006932 SMTN Hs00199489_m1 AF064238 SMTN Hs00199489_m1 NM_003068 SNAI2 Hs00950344_m1 NM_018013 SOBP Hs00215979_m1 NM_020777 SORCS2 Hs00325181_m1 NM_003118 SPARC Hs00277762_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_021972 SPHK1 Hs00184211_m1 AF231124 SPOCK1 Hs00270274_m1 AB051390 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_025106 SPSB1 Hs00228304_m1 NM_025106 SPSB1 Hs00228304_m1 NM_006307 SRPX Hs00196867_m1 NM_014467 SRPX2 Hs00997580_m1 AL136756 SSPN Hs00296706_s1 NM_005086 SSPN Hs00296706_s1 NM_006927 ST3GAL2 Hs00199480_m1 NM_005418 ST5 Hs00936461_m1 NM_032528 ST6GAL2 Hs00290088_s1 NM_015170 SULF1 Hs00290918_m1 NM_015170 SULF1 Hs00290918_m1 NM_018837 SULF2 Hs00378697_m1 NM_033025 SYDE1 Hs00263581_m1 NM_033025 SYDE1 Hs00263581_m1 NM_024893 SYNDIG1 Hs00227616_m1 86 NM_007286 SYNPO Hs00702468_s1 NM_080737 SYTL4 Hs00299039_m1 NM_003186 TAGLN Hs00162558_m1 NM_014604 TAX1BP3 Hs00205924_m1 AF234997 TAX1BP3 Hs00205924_m1 NM_015079 TBC1D2B Hs00534954_m1 NM_152380 TBX15 Hs00537087_m1 NM_000192 TBX5 Hs00361155_m1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 BC000125 TGFB1 Hs00998133_m1 BC001830 TGFB1I1 Hs00210887_m1 J03241 TGFB3 Hs01086000_m1 NM_000358 TGFBI Hs03987596_s1 NM_003247 THBS2 Hs01568063_m1 L38969 THBS3 Hs00200157_m1 NM_006288 THY1 Hs00264235_s1 NM_006288 THY1 Hs00264235_s1 AL161958 THY1 Hs00264235_s1 NM_005424 TIE1 Hs00892696_m1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 U67195 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_024600 TMEM204 Hs01061927_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_001065 TNFRSF1A Hs00533568_g1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_022748 TNS3 Hs00224228_m1 NM_003289 TPM2 Hs00268540_m1 NM_012288 TRAM2 Hs00202213_m1 NM_003304 TRPC1 Hs00608195_m1 NM_003304 TRPC1 Hs00608195_m1 NM_020856 TSHZ3 Hs02379784_s1 AL136805 TSHZ3 Hs02379784_s1 NM_005725 TSPAN2 Hs00194836_m1 87 BC002654 TUBB6 Hs00603164_m1 NM_000474 TWIST1 Hs00361186_m1 AF322916 UACA Hs00326052_m1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 NM_014909 VASH1 Hs00208609_m1 D32039 VCAN Hs01007941_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_014000 VCL Hs00243320_m1 U58111 VEGFC Hs01099206_m1 NM_014667 VGLL4 Hs00382574_m1 NM_003380 VIM Hs00958116_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_152348 WDR81 Hs00400556_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003881 WISP2 Hs00180242_m1 NM_015472 WWTR1 Hs00210007_m1 NM_145166 ZBTB47 Hs00908860_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_030751 ZEB1 Hs01566407_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_024721 ZFHX4 Hs00257312_s1 NM_012082 ZFPM2 Hs00201397_m1 NM_015069 ZNF423 Hs00323880_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 NM_018181 ZNF532 Hs00539543_m1 NM_024706 ZNF668 Hs00226767_m1 NM_001010972 ZYX Hs00170299_m1 NM_003461 ZYX Hs00170299_m1 THEM6 Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_174922 ADCK5 Hs00381695_g1 88 NM_007002 ADRM1 Hs00199645_m1 NM_005787 ALG3 Hs00271780_m1 NM_025251 ARHGAP39 Hs00286798_m1 NM_001694 ATP6V0C Hs00798308_sH NM_015201 BOP1 Hs00374884_m1 NM_015201 BOP1 Hs00374884_m1 BC004446 C20orf24 Hs00218951_m1 NM_018840 C20orf24 Hs00218951_m1 AF274948 C20orf24 Hs00218951_m1 NM_023080 C8orf33 Hs00535769_m1 NM_023080 C8orf33 Hs00535769_m1 NM_152416 C8orf38 Hs00415126_m1 NM_001001795 C8orf82 Hs01575194_m1 NM_001306 CLDN3 Hs00265816_s1 NM_001306 CLDN3 Hs00265816_s1 AF290195 COMMD5 Hs00204138_m1 BC003055 COMMD5 Hs00986545_m1 NM_003909 CPNE3 Hs01122594_m1 NM_013291 CPSF1 Hs00273612_m1 NM_013291 CPSF1 Hs00273612_m1 NM_001916 CYC1 Hs00357717_m1 NM_032687 CYHR1 Hs00402078_g1 BC005073 CYHR1 Hs00402078_g1 NM_032687 CYHR1 Hs00402078_g1 NM_024295 DERL1 Hs00251475_s1 NM_012079 DGAT1 Hs00201385_m1 NM_001960 EEF1D Hs02339452_g1 NM_001960 EEF1D Hs02339452_g1 NM_019037 EXOSC4 Hs00363401_g1 NM_019037 EXOSC4 Hs00363401_g1 NM_019037 EXOSC4 Hs00363401_g1 AF151022 FAM203A Hs00367709_g1 NM_016458 FAM203A Hs00367709_g1 NM_198488 FAM83H Hs00294647_s1 NM_024555 FBXL6 Hs00226123_m1 NM_138465 GLI4 Hs00294078_m1 NM_003801 GPAA1 Hs00186931_m1 NM_003801 GPAA1 Hs00186931_m1 NM_024531 GPR172A Hs01859203_s1 NM_024531 GPR172A Hs01859203_s1 NM_000837 GRINA Hs00418129_g1 NM_024736 GSDMD Hs00226875_m1 NM_005526 HSF1 Hs00232134_m1 NM_005526 HSF1 Hs00232134_m1 NM_145754 KIFC2 Hs00377525_m1 89 NM_145754 KIFC2 Hs00377525_m1 NM_014665 LRRC14 Hs00206378_m1 NM_014665 LRRC14 Hs00206378_m1 NM_002346 LY6E Hs00158942_m1 AL136937 MAF1 Hs00361082_g1 NM_138431 MFSD3 Hs00293683_m1 NM_022372 MLST8 Hs00375430_m1 NM_002949 MRPL12 Hs00243186_m1 NM_014078 MRPL13 Hs01091048_m1 NM_014175 MRPL15 Hs00204356_m1 NM_021107 MRPS12 Hs00221633_m1 NM_178812 MTDH Hs00757833_m1 NM_014637 MTFR1 Hs00206110_m1 NM_014637 MTFR1 Hs00206110_m1 AF261090 NDUFB9 Hs00601381_mH U79718 NTHL1 Hs00267385_m1 NM_017570 OPLAH Hs00417215_m1 NM_005034 POLR2K Hs01562397_m1 NM_005034 POLR2K Hs01562397_m1 NM_032902 PPP1R16A Hs00262830_m1 NM_014754 PTDSS1 Hs00207371_m1 NM_005607 PTK2 Hs01056457_m1 NM_005607 PTK2 Hs01056457_m1 AF217197 PUF60 Hs01050528_g1 NM_023078 PYCRL Hs00985624_m1 NM_016732 RALY Hs00249817_m1 NM_004260 RECQL4 Hs00171627_m1 NM_052924 RHPN1 Hs00379557_m1 NM_000973 RPL8 Hs00361285_g1 NM_058192 RPUSD1 Hs00369703_m1 BC001811 RRS1 Hs00534971_s1 NM_015356 SCRIB Hs00363005_m1 NM_030974 SHARPIN Hs00229642_m1 BC003068 SLC19A1 Hs00953344_m1 U25147 SLC25A1 Hs00761590_sH NM_012140 SLC25A10 Hs00201730_m1 NM_017767 SLC39A4 Hs00214912_m1 NM_003129 SQLE Hs01123768_m1 AF098865 SQLE Hs01123768_m1 NM_005648 TCEB1 Hs00855349_g1 NM_032862 TIGD5 Hs00262637_s1 NM_005834 TIMM17B Hs00758442_m1 NM_017866 TMEM70 Hs00215349_m1 NM_014573 TMEM97 Hs00299877_m1 NM_052963 TOP1MT Hs00369537_m1 90 NM_031466 TRAPPC9 Hs00230278_m1 NM_031466 TRAPPC9 Hs00230278_m1 NM_145003 TSNARE1 Hs00417030_m1 NM_003313 TSTA3 Hs00163023_m1 NM_003313 TSTA3 Hs00163023_m1 NM_016208 VPS28 Hs00211938_m1 NM_018024 WDYHV1 Hs00216009_m1 NM_001017964 YDJC Hs00419214_g1 NM_003406 YWHAZ Hs00852925_sH NM_003406 YWHAZ Hs00852925_sH NM_015117 ZC3H3 Hs00299449_m1 NM_006958 ZNF16 Hs00705748_s1 NM_030580 ZNF34 Hs00228999_m1 NM_014789 ZNF623 Hs00706213_s1 NM_030895 ZNF696 Hs00229425_m1 NM_003416 ZNF7 Hs00171565_m1 NM_016096 ZNF706 Hs00706404_s1 NM_173831 ZNF707 Hs00385456_m1 CAPRIN1 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_006595 API5 Hs00972630_g1 NM_152641 ARID2 Hs00326029_m1 BC005071 BTBD10 Hs00260470_m1 NM_152316 C11orf46 Hs01876789_s1 NM_014267 C11orf58 Hs00702504_s1 NM_014267 C11orf58 Hs00702504_s1 NM_152409 C5orf24 Hs01594521_m1 AL136810 CAND1 Hs00218384_m1 NM_005898 CAPRIN1 Hs01075318_m1 NM_005898 CAPRIN1 Hs01075318_m1 NM_005898 CAPRIN1 Hs01075318_m1 NM_005898 CAPRIN1 Hs01075318_m1 NM_005898 CAPRIN1 Hs01075318_m1 NM_005898 CAPRIN1 Hs01075318_m1 NM_030771 CCDC34 Hs00293234_m1 NM_018318 CCDC91 Hs00217828_m1 NM_032221 CHD6 Hs00325206_m1 NM_000390 CHM Hs00708359_s1 NM_004236 COPS2 Hs00182826_m1 NM_001031812 CSNK1G3 Hs00177858_m1 NM_003590 CUL3 Hs00180183_m1 NM_016221 DCTN4 Hs00211976_m1 NM_003677 DENR Hs00795562_s1 91 NM_001012339 DNAJC21 Hs00288009_m1 NM_001012339 DNAJC21 Hs00288009_m1 NM_206831 DPH3 Hs00761040_s1 NM_001968 EIF4E Hs00854166_g1 NM_173511 FAM117B Hs00403039_m1 NM_022063 FAM204A Hs00222878_m1 NM_173611 FAM98B Hs00543341_m1 NM_032228 FAR1 Hs00386153_m1 NM_012160 FBXL4 Hs00273315_m1 NM_012175 FBXO3 Hs00201809_m1 NM_012175 FBXO3 Hs00201809_m1 NM_178439 GMCL1 Hs00703629_s1 NM_022913 GPBP1 Hs00607556_m1 NM_152407 GRPEL2 Hs00537120_s1 NM_022482 GZF1 Hs00223905_m1 NM_006805 HNRNPA0 Hs00246543_s1 NM_006805 HNRNPA0 Hs00246543_s1 NM_138394 HNRPLL Hs00293181_m1 NM_022466 IKZF5 Hs00223846_m1 NM_144981 IMMP1L Hs00758295_g1 NM_016475 JKAMP Hs00255559_m1 NM_152903 KBTBD6 Hs01650625_s1 NM_020122 KCMF1 Hs01549125_m1 NM_021970 LAMTOR3 Hs00179753_m1 NM_018362 LIN7C Hs00218015_m1 NM_032622 LNX1 Hs00261754_m1 NM_017824 MARCH5 Hs00215155_m1 NM_018834 MATR3 Hs00251579_m1 NM_203406 MBLAC2 Hs00736566_m1 NM_006838 METAP2 Hs01127366_m1 NM_212554 METTL10 Hs00379680_m1 BC000195 METTL9 Hs00367590_m1 NM_020774 MIB1 Hs00379185_m1 NM_152622 MIER3 Hs00401662_m1 NM_014342 MTCH2 Hs00819318_g1 AL136920 PAIP1 Hs00603735_g1 NM_006451 PAIP1 Hs00603735_g1 NM_003477 PDHX Hs00185790_m1 NM_032177 PHAX Hs00536084_m1 NM_001031689 PLAA Hs00972148_m1 NM_004792 PPIG Hs01081188_gH NM_021003 PPM1A Hs00221372_m1 NM_002721 PPP6C Hs00254827_m1 NM_002721 PPP6C Hs00254827_m1 NM_004663 RAB11A Hs00900539_m1 92 NM_021252 RAB18 Hs00222021_m1 NM_014999 RAB21 Hs00209226_m1 NM_006267 RANBP2 Hs00397898_g1 NM_006047 RBM12 Hs00246072_s1 NM_033117 RBM18 Hs00263878_m1 NM_018151 RIF1 Hs00871714_m1 NM_016120 RLIM Hs00602952_m1 NM_016422 RNF141 Hs00212656_m1 NM_152682 RWDD4 Hs00386192_g1 NM_017988 SCYL2 Hs00250551_m1 NM_016275 SELT Hs00892526_g1 NM_014554 SENP1 Hs01060367_m1 NM_006345 SLC30A9 Hs00197118_m1 NM_012243 SLC35A3 Hs00911515_m1 NM_006425 SLU7 Hs00197528_m1 NM_001001419 SMAD5 Hs00289739_s1 NM_020463 SMEK2 Hs00383278_m1 NM_194285 SPTY2D1 Hs00827244_m1 AF107405 SRSF3 Hs00751507_s1 NM_003932 ST13 Hs00832556_sH NM_018374 TMEM106B Hs00332866_s1 NM_017583 TRIM44 Hs00214040_m1 NM_017583 TRIM44 Hs00214040_m1 NM_006292 TSG101 Hs01121709_m1 NM_020784 TXNDC16 Hs00394095_m1 BC005979 UBE2B Hs00163311_m1 NM_005339 UBE2K Hs01001790_m1 NM_003348 UBE2N Hs00854751_s1 NM_001001481 UBE2W Hs00217672_m1 NM_172070 UBR3 Hs00542490_m1 NM_172070 UBR3 Hs00542490_m1 NM_018314 UEVLD Hs00217789_m1 NM_032557 USP38 Hs00261419_m1 NM_017944 USP47 Hs00215725_m1 NM_017599 VEZT Hs00250257_m1 NM_139281 WDR36 Hs00291795_s1 NM_020924 ZBTB26 Hs00363648_s1 NM_021964 ZNF148 Hs00222661_m1 BC006279 ZNF627 Hs00377160_g1 NM_016096 ZNF706 Hs00706404_s1 NM_152601 ZNF709 Hs00708414_s1 93 CCT7 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_001087 AAMP Hs00153682_m1 NM_007274 ACOT7 Hs00739006_m1 NM_007274 ACOT7 Hs00739006_m1 NM_004300 ACP1 Hs00244706_g1 NM_004300 ACP1 Hs00244706_g1 NM_000687 AHCY Hs00898135_gH NM_012111 AHSA1 Hs00201602_m1 NM_006303 AIMP2 Hs00196842_m1 NM_006303 AIMP2 Hs00196842_m1 AF151034 ANKRD39 Hs00212844_m1 NM_000485 APRT Hs00356991_m1 NM_030978 ARPC5L Hs00229649_m1 BC000018 ARPC5L Hs00229649_m1 NM_001686 ATP5B Hs00969569_m1 NM_001001973 ATP5C1 Hs01101219_g1 NM_001689 ATP5G3 Hs00266085_m1 NM_001689 ATP5G3 Hs00266085_m1 NM_001168 BIRC5 Hs03063352_s1 NM_015201 BOP1 Hs00374884_m1 NM_004053 BYSL Hs00608266_m1 NM_024520 C2orf47 Hs00225928_m1 NM_178448 C9orf140 Hs00746788_s1 NM_031966 CCNB1 Hs01030103_m1 NM_031966 CCNB1 Hs01030103_m1 NM_004701 CCNB2 Hs01084597_g1 NM_006431 CCT2 Hs00197562_m1 NM_005998 CCT3 Hs01090729_g1 NM_006430 CCT4 Hs00272345_m1 NM_000075 CDK4 Hs00364847_m1 NM_001809 CENPA Hs00903938_g1 NM_016139 CHCHD2 Hs00853326_g1 NM_004804 CIAO1 Hs00191307_m1 NM_001827 CKS2 Hs00854958_g1 NM_006012 CLPP Hs00195655_m1 NM_006067 COX4NB Hs00196000_m1 NM_004255 COX5A Hs00362067_m1 NM_001862 COX5B Hs00426948_m1 BC006229 COX5B Hs00426948_m1 NM_001862 COX5B Hs00426948_m1 NM_004718 COX7A2L Hs00190880_m1 NM_016207 CPSF3 Hs00211919_m1 NM_001916 CYC1 Hs00357717_m1 94 NM_005804 DDX39A Hs00271794_m1 BC001121 DGUOK Hs00361549_m1 NM_001363 DKC1 Hs00154737_m1 U59151 DKC1 Hs00154737_m1 AF226998 DPY30 Hs00261491_m1 NM_012145 DTYMK Hs00992744_m1 NM_006579 EBP Hs00198130_m1 NM_032331 ECE2 Hs04189541_g1 BC001173 EIF3B Hs00186732_m1 AF047695 EIF4E2 Hs00601369_g1 AF022229 EIF6 Hs00158272_m1 NM_001419 ELAVL1 Hs00171309_m1 NM_033505 EPT1 Hs01013816_m1 NM_014285 EXOSC2 Hs00204705_m1 NM_019037 EXOSC4 Hs00363401_g1 NM_019037 EXOSC4 Hs00363401_g1 NM_019037 EXOSC4 Hs00363401_g1 NM_020158 EXOSC5 Hs00220083_m1 NM_032822 FAM136A Hs00852529_g1 NM_016049 FAM158A Hs00211377_m1 NM_004461 FARSA Hs00189494_m1 AF161521 FARSB Hs00271714_m1 NM_012170 FBXO22 Hs00201796_m1 NM_002014 FKBP4 Hs00427038_g1 NM_021953 FOXM1 Hs00153543_m1 NM_052850 GADD45GIP1 Hs00369339_m1 NM_002046 GAPDH Hs03929097_g1 NM_002046 GAPDH Hs03929097_g1 NM_024775 GEMIN6 Hs00276734_m1 AF118652 GLRX3 Hs01582641_g1 BC000498 GOT1 Hs00157798_m1 NM_025196 GRPEL1 Hs00379355_m1 NM_025196 GRPEL1 Hs00379355_m1 NM_002106 H2AFZ Hs01888362_g1 NM_002106 H2AFZ Hs01888362_g1 NM_016185 HN1 Hs00602957_m1 NM_004493 HSD17B10 Hs00189576_m1 AF275719 HSP90AB1 Hs00607336_gH NM_002156 HSPD1 Hs01866140_g1 NM_002156 HSPD1 Hs01866140_g1 NM_002157 HSPE1 Hs01654720_g1 NM_033416 IMP4 Hs00394979_m1 NM_020122 KCMF1 Hs01549125_m1 BC005978 KPNA2 Hs00818252_g1 M92439 LRPPRC Hs00370169_g1 95 NM_012321 LSM4 Hs00202406_m1 NM_012321 LSM4 Hs00202406_m1 NM_016199 LSM7 Hs00211890_m1 NM_002358 MAD2L1 Hs00829154_g1 NM_005917 MDH1 Hs00936497_g1 BC001396 METTL11A Hs00894565_m1 NM_002949 MRPL12 Hs00243186_m1 NM_032111 MRPL14 Hs00372862_m1 NM_022061 MRPL17 Hs00222867_m1 NM_014161 MRPL18 Hs00204310_m1 AB049654 MRPL36 Hs00852169_g1 AF325707 MRPL37 Hs00212894_m1 AB049944 MRPS11 Hs00602553_m1 NM_021107 MRPS12 Hs00221633_m1 NM_031280 MRPS15 Hs00229834_m1 NM_015969 MRPS17 Hs00706351_s1 NM_016034 MRPS2 Hs00211334_m1 BC000242 MRPS23 Hs00608544_m1 NM_032014 MRPS24 Hs00364044_m1 NM_015971 MRPS7 Hs00211079_m1 NM_182640 MRPS9 Hs00396989_m1 NM_016183 MRTO4 Hs00607404_g1 NM_014342 MTCH2 Hs00819318_g1 NM_006636 MTHFD2 Hs00759197_s1 NM_003491 NAA10 Hs00185854_m1 NM_175614 NDUFA11 Hs00418302_m1 NM_014222 NDUFA8 Hs00204417_m1 AF050641 NDUFA9 Hs00245308_m1 AF261090 NDUFB9 Hs00601381_mH NM_004551 NDUFS3 Hs01549083_m1 NM_004553 NDUFS6 Hs00190035_m1 NM_000269 NME1 Hs02621161_s1 NM_016391 NOP16 Hs00212622_m1 NM_016391 NOP16 Hs00212622_m1 BC000245 NSDHL Hs00940273_m1 AF241788 NUDC Hs00702452_s1 NM_006452 PAICS Hs00272390_m1 NM_006452 PAICS Hs00272390_m1 D25547 PCMT1 Hs00193600_m1 NM_004708 PDCD5 Hs00270435_m1 NM_002634 PHB Hs00855044_g1 NM_015160 PMPCA Hs00299419_m1 NM_020143 PNO1 Hs00220044_m1 NM_006230 POLD2 Hs00371762_m1 NM_004805 POLR2D Hs00797358_s1 96 BC003582 POLR2F Hs00222679_m1 NM_006233 POLR2I Hs01042086_g1 BC003048 PPIL1 Hs00798372_s1 NM_002712 PPP1R7 Hs00160366_m1 NM_005710 PQBP1 Hs00172888_m1 NM_001032381 PQBP1 Hs00172888_m1 NM_003981 PRC1 Hs01597831_m1 NM_006406 PRDX4 Hs00197394_m1 AF153607 PRELID1 Hs02638995_g1 NM_001536 PRMT1 Hs01587651_g1 NM_002792 PSMA7 Hs00895424_m1 NM_002792 PSMA7 Hs00895424_m1 NM_002799 PSMB7 Hs00160607_m1 NM_002804 PSMC3 Hs00267682_m1 NM_005805 PSMD14 Hs01113429_m1 NM_002808 PSMD2 Hs01092070_g1 NM_002812 PSMD8 Hs00601309_m1 NM_003720 PSMG1 Hs00186605_m1 NM_004219 PTTG1 Hs00851754_u1 AF054183 RAN Hs00741099_g1 NM_002882 RANBP1 Hs01597912_g1 L03411 RDBP Hs00267952_m1 M87338 RFC2 Hs00945948_m1 NM_002914 RFC2 Hs00945948_m1 NM_006397 RNASEH2A Hs00197370_m1 NM_016093 RPL26L1 Hs01631495_s1 NM_001034 RRM2 Hs01072069_g1 BC001886 RRM2 Hs01072069_g1 NM_003707 RUVBL1 Hs00186558_m1 NM_006666 RUVBL2 Hs01090542_m1 AF184213 SF3B14 Hs00255423_m1 NM_031287 SF3B5 Hs02379840_s1 NM_005412 SHMT2 Hs00193658_m1 NM_006857 SNRNP27 Hs00386296_m1 NM_003090 SNRPA1 Hs00795392_mH J04564 SNRPB Hs00268321_m1 NM_003091 SNRPB Hs00268321_m1 BC001721 SNRPD1 Hs00762441_s1 NM_004597 SNRPD2 Hs00817686_mH NM_003096 SNRPG Hs01923241_g1 NM_006463 STAMBP Hs00197726_m1 NM_006819 STIP1 Hs00428979_m1 NM_006819 STIP1 Hs00428979_m1 NM_013442 STOML2 Hs00203730_m1 NM_003849 SUCLG1 Hs00388749_m1 97 NM_017503 SURF2 Hs00213828_m1 NM_006755 TALDO1 Hs00997203_m1 AF151073 TBC1D7 Hs00212898_m1 NM_005648 TCEB1 Hs00855349_g1 NM_012458 TIMM13 Hs00606550_g1 NM_006327 TIMM23 Hs00197056_m1 NM_006327 TIMM23 Hs00197056_m1 NM_001001563 TIMM50 Hs00859225_m1 NM_000365 TPI1 Hs01593134_gH NM_004237 TRIP13 Hs01020069_m1 NM_003310 TSSC1 Hs00964450_m1 AF313911 TXN Hs01555212_g1 NM_006701 TXNL4A Hs00198633_m1 NM_014501 UBE2S Hs00819350_m1 AB032931 UBE2T Hs00204359_m1 BC002906 UCK2 Hs00367072_m1 NM_006590 USP39 Hs00198180_m1 NM_018256 WDR12 Hs00372531_g1 NM_017588 WDR5 Hs00424605_m1 CMA1 Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_007168 ABCA8 Hs00992371_m1 NM_001911 CTSG Hs00175195_m1 NM_018659 CYTL1 Hs01573280_m1 NM_002036 DARC Hs01011079_s1 BC005912 FCER1A Hs00758600_m1 NM_004469 FIGF Hs00189521_m1 NM_005031 FXYD1 Hs00245327_m1 NM_004962 GDF10 Hs01086867_m1 AB024518 IL33 Hs00369211_m1 AF128846 INMT Hs00198941_m1 NM_006691 LYVE1 Hs00272659_m1 NM_004527 MEOX1 Hs00244943_m1 NM_002404 MFAP4 Hs00412974_m1 NM_000139 MS4A2 Hs00175091_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_173833 SCARA5 Hs01073151_m1 NM_173833 SCARA5 Hs01073151_m1 NM_004657 SDPR Hs00190538_m1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 98 COL14A1 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_000014 A2M Hs00163474_m1 NM_005763 AASS Hs00194991_m1 NM_080284 ABCA6 Hs00365329_m1 NM_007168 ABCA8 Hs00992371_m1 NM_080283 ABCA9 Hs00329320_m1 NM_080283 ABCA9 Hs00329320_m1 NM_080283 ABCA9 Hs00329320_m1 AF016535 ABCB1 Hs01067802_m1 AF016535 ABCB1 Hs01067802_m1 NM_005050 ABCD4 Hs00929495_m1 AF098951 ABCG2 Hs01053787_m1 AB056106 ABI3BP Hs00248821_m1 NM_001093 ACACB Hs01565927_g1 NM_001093 ACACB Hs01565927_g1 NM_001613 ACTA2 Hs00426835_g1 NM_001613 ACTA2 Hs00426835_g1 NM_001105 ACVR1 Hs00153836_m1 NM_001616 ACVR2A Hs00155658_m1 NM_000020 ACVRL1 Hs00163543_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_025220 ADAM33 Hs00296426_m1 NM_025220 ADAM33 Hs00296426_m1 NM_006988 ADAMTS1 Hs01095532_g1 NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_001121 ADD3 Hs00249890_m1 NM_019903 ADD3 Hs00249890_m1 NM_001121 ADD3 Hs00249890_m1 AF153821 ADH1B Hs00605175_m1 M24317 ADH1B Hs00605175_m1 M21692 ADH1B Hs00605175_m1 NM_004797 ADIPOQ Hs02564413_s1 AF284095 ADRA2A Hs00265081_s1 NM_001129 AEBP1 Hs00937468_m1 NM_005935 AFF1 Hs00610550_m1 NM_006796 AFG3L2 Hs00255224_m1 NM_001620 AHNAK Hs00300657_s1 99 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_006738 AKAP13 Hs00331658_s1 NM_005465 AKT3 Hs00289302_s1 NM_000689 ALDH1A1 Hs00167445_m1 AB015228 ALDH1A2 Hs00180254_m1 NM_001034173 ALDH1L2 Hs00402876_m1 NM_130847 AMOTL1 Hs00294070_m1 AB056476 ANGPTL1 Hs00559786_m1 NM_004673 ANGPTL1 Hs00559786_m1 NM_004673 ANGPTL1 Hs00559786_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_001148 ANK2 Hs00153998_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_000700 ANXA1 Hs00945401_m1 NM_003734 AOC3 Hs00186647_m1 NM_001647 APOD Hs00155794_m1 NM_022481 ARAP3 Hs00223903_m1 NM_020809 ARHGAP20 Hs00826991_m1 NM_001025616 ARHGAP24 Hs01097580_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_014629 ARHGEF10 Hs00206020_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_032199 ARID5B Hs01382781_m1 NM_183376 ARRDC4 Hs00411771_m1 AF316824 ASPN Hs00214395_m1 NM_017680 ASPN Hs00214395_m1 NM_020453 ATP10D Hs00935004_m1 NM_001003696 ATP5J Hs01081389_g1 NM_001003803 ATP5S Hs00210402_m1 NM_000332 ATXN1 Hs00165656_m1 NM_021913 AXL Hs01064444_m1 NM_012104 BACE1 Hs01123242_m1 NM_021813 BACH2 Hs00222364_m1 NM_020139 BDH2 Hs01009428_g1 NM_001711 BGN Hs00959143_m1 BC002416 BGN Hs00959143_m1 100 NM_152414 BHLHE22 Hs01084964_s1 NM_030762 BHLHE41 Hs00229146_m1 NM_017614 BHMT2 Hs00214120_m1 NM_017614 BHMT2 Hs00214120_m1 NM_001204 BMPR2 Hs00176148_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 AY027658 BOC Hs00264408_m1 NM_033254 BOC Hs00264408_m1 NM_006763 BTG2 Hs00198887_m1 NM_152547 BTNL9 Hs00537320_m1 AL136653 C10orf10 Hs00199735_m1 NM_017787 C10orf26 Hs00740771_s1 NM_024631 C11orf61 Hs00226408_m1 NM_032849 C13orf33 Hs00262558_m1 AF329841 C1QTNF5 Hs00363053_g1 NM_031911 C1QTNF7 Hs00230467_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 AF325503 C2orf40 Hs00260897_m1 NM_000064 C3 Hs00163811_m1 NM_015224 C3orf63 Hs00248615_m1 AF329088 C4orf49 Hs00261759_m1 NM_004772 C5orf13 Hs00854282_g1 NM_001007189 C5orf53 Hs00759532_s1 AF313413 C5orf62 Hs00383944_m1 NM_000587 C7 Hs00175109_m1 NM_024913 C7orf58 Hs00227735_m1 NM_020925 CACHD1 Hs00326087_m1 NM_000722 CACNA2D1 Hs00984856_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 AF356193 CARD6 Hs01123611_m1 NM_001753 CAV1 Hs00971716_m1 NM_001753 CAV1 Hs00971716_m1 NM_001233 CAV2 Hs00184597_m1 NM_001233 CAV2 Hs00184597_m1 NM_175709 CBX7 Hs00545603_m1 AL136562 CCDC3 Hs00230222_m1 NM_174908 CCDC50 Hs00291696_s1 101 NM_174908 CCDC50 Hs00291696_s1 AL136609 CCDC8 Hs00540204_s1 NM_032040 CCDC8 Hs00540204_s1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_001759 CCND2 Hs00922419_g1 AF063591 CD200 Hs01033303_m1 NM_020404 CD248 Hs00535586_s1 NM_014880 CD302 Hs00208436_m1 M81104 CD34 Hs00990735_m1 NM_000072 CD36 Hs01567186_m1 NM_000072 CD36 Hs01567186_m1 NM_012072 CD93 Hs00362607_m1 NM_012072 CD93 Hs00362607_m1 NM_002414 CD99 Hs00365982_m1 NM_003671 CDC14B Hs00269351_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_001795 CDH5 Hs00901463_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_004936 CDKN2B Hs00793225_m1 NM_001801 CDO1 Hs00156447_m1 U69546 CELF2 Hs00990166_m1 NM_006561 CELF2 Hs00990166_m1 AB011154 CEP68 Hs00209465_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_000204 CFI Hs00989715_m1 NM_003956 CH25H Hs02379634_s1 NM_006614 CHL1 Hs00544069_m1 NM_145234 CHRDL1 Hs00292767_m1 NM_003613 CILP Hs00173647_m1 NM_005602 CLDN11 Hs00194440_m1 NM_003277 CLDN5 Hs00533949_s1 BC005810 CLEC11A Hs00161544_m1 NM_175060 CLEC14A Hs00545534_s1 NM_003278 CLEC3B Hs00162844_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 102 NM_001299 CNN1 Hs00154543_m1 NM_015463 CNRIP1 Hs00384403_m1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 NM_001856 COL16A1 Hs00156876_m1 NM_030582 COL18A1 Hs01043425_g1 AF018081 COL18A1 Hs01043425_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 NM_000393 COL5A2 Hs00893923_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 AY029208 COL6A2 Hs00242484_m1 NM_001849 COL6A2 Hs00242484_m1 NM_004369 COL6A3 Hs00915120_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006091 CORO2B Hs00379744_m1 NM_001864 COX7A1 Hs00156989_m1 NM_001864 COX7A1 Hs00156989_m1 NM_001870 CPA3 Hs00157019_m1 NM_001873 CPE Hs00175676_m1 NM_001873 CPE Hs00175676_m1 NM_019609 CPXM1 Hs01566704_g1 NM_198148 CPXM2 Hs00406866_m1 BC006393 CPZ Hs00186333_m1 NM_016441 CRIM1 Hs00212750_m1 AL136861 CRISPLD2 Hs00230322_m1 NM_006371 CRTAP Hs00197261_m1 NM_021117 CRY2 Hs00323654_m1 NM_018371 CSGALNACT1 Hs00218054_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_000396 CTSK Hs00166156_m1 103 NM_001334 CTSO Hs00154656_m1 U20350 CX3CR1 Hs01922583_s1 NM_000609 CXCL12 Hs00930455_m1 NM_004887 CXCL14 Hs00171135_m1 AF144103 CXCL14 Hs00171135_m1 NM_024689 CXorf36 Hs00226702_m1 NM_024689 CXorf36 Hs00226702_m1 AL136693 CYBRD1 Hs00227411_m1 NM_134268 CYGB Hs00370478_m1 NM_000104 CYP1B1 Hs00164383_m1 NM_000104 CYP1B1 Hs00164383_m1 NM_183075 CYP2U1 Hs00766273_m1 AF003114 CYR61 Hs00998503_g1 NM_001554 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 NM_052954 CYYR1 Hs00364793_m1 BC003064 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_002036 DARC Hs01011079_s1 NM_003737 DCHS1 Hs01044548_m1 NM_001920 DCN Hs00754870_s1 AF138303 DCN Hs00266491_m1 NM_001920 DCN Hs00754870_s1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_006182 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_014974 DIP2C Hs00324224_m1 NM_033425 DIXDC1 Hs00736707_m1 NM_014421 DKK2 Hs00205294_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 AF026219 DLC1 Hs00931487_m1 NM_006094 DLC1 Hs00183436_m1 NM_004010 DMD Hs01049460_m1 NM_001005336 DNM1 Hs00189369_m1 NM_001380 DOCK1 Hs00169192_m1 NM_001935 DPP4 Hs00175210_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 104 NM_001937 DPT Hs00355056_m1 NM_001386 DPYSL2 Hs00954558_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_032160 DSEL Hs00707488_s1 NM_001723 DST Hs00794953_m1 NM_001723 DST Hs00794953_m1 NM_001723 DST Hs00794953_m1 NM_004417 DUSP1 Hs00610257_g1 NM_014934 DZIP1 Hs00208790_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_001005463 EBF3 Hs00291943_s1 NM_001005463 EBF3 Hs00291943_s1 NM_001393 ECM2 Hs00154821_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 M74921 EDNRB Hs00240752_m1 AB030655 EFEMP2 Hs00213545_m1 NM_016938 EFEMP2 Hs00213545_m1 NM_181723 EFHA2 Hs01028469_m1 NM_152403 EGFLAM Hs00794831_m1 NM_001964 EGR1 Hs00152928_m1 NM_001964 EGR1 Hs00152928_m1 NM_001964 EGR1 Hs00152928_m1 NM_000399 EGR2 Hs00166165_m1 NM_004430 EGR3 Hs00231780_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_005230 ELK3 Hs00987814_m1 NM_000501 ELN Hs01091772_m1 NM_022159 ELTD1 Hs03987598_m1 NM_016242 EMCN Hs01038209_m1 NM_016242 EMCN Hs01038209_m1 AF205940 EMCN Hs01038209_m1 NM_016242 EMCN Hs01038209_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_004098 EMX2 Hs00244574_m1 D45421 ENPP2 Hs00196470_m1 L35594 ENPP2 Hs00196470_m1 U87967 ENTPD1 Hs00969559_m1 105 NM_001776 ENTPD1 Hs00739960_s1 NM_001776 ENTPD1 Hs00739960_s1 NM_001430 EPAS1 Hs01026142_m1 NM_001430 EPAS1 Hs01026142_m1 NM_012156 EPB41L1 Hs00385004_m1 NM_001431 EPB41L2 Hs00154988_m1 NM_004449 ERG Hs01554635_m1 NM_004449 ERG Hs01554635_m1 NM_138961 ESAM Hs00332781_m1 NM_005239 ETS2 Hs00232009_m1 NM_147127 EVC2 Hs00377633_m1 NM_000129 F13A1 Hs00173388_m1 NM_001992 F2R Hs00169258_m1 NM_004101 F2RL2 Hs00187982_m1 NM_001442 FABP4 Hs01086178_g1 NM_138333 FAM122A Hs00540770_s1 NM_032581 FAM126A Hs00261521_m1 NM_032042 FAM172A Hs00230742_m1 NM_153690 FAM43A Hs00538124_s1 U76833 FAP Hs00990806_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001996 FBLN1 Hs00242546_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 NM_153214 FBLN7 Hs00402230_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_012158 FBXL3 Hs01045265_m1 BC005912 FCER1A Hs00758600_m1 NM_006832 FERMT2 Hs01041255_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 NM_000800 FGF1 Hs00265254_m1 NM_003862 FGF18 Hs00818572_m1 NM_003862 FGF18 Hs00818572_m1 NM_002009 FGF7 Hs00173565_m1 U29538 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 AF098518 FHL1 Hs00793641_g1 AF063002 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 NM_020482 FHL5 Hs00220910_m1 106 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 NM_004469 FIGF Hs00189521_m1 AF100751 FKBP7 Hs00535040_m1 NM_007270 FKBP9 Hs00414859_m1 NM_207422 FLJ44635 Hs00885839_s1 NM_001458 FLNC Hs00155124_m1 AF169676 FLRT2 Hs00544171_s1 NM_013231 FLRT2 Hs00544171_s1 BC005894 FMO2 Hs00155158_m1 NM_001460 FMO2 Hs00155158_m1 NM_002023 FMOD Hs00157619_m1 BC004490 FOS Hs01119267_g1 NM_006732 FOSB Hs01547109_m1 NM_001452 FOXF2 Hs00230963_m1 NM_005197 FOXN3 Hs00830558_g1 NM_005197 FOXN3 Hs00830558_g1 NM_002015 FOXO1 Hs00231106_m1 NM_144966 FREM1 Hs00381549_m1 NM_144966 FREM1 Hs00381549_m1 NM_152330 FRMD6 Hs00378563_m1 NM_152330 FRMD6 Hs00378563_m1 NM_001463 FRZB Hs00173503_m1 U91903 FRZB Hs00173503_m1 NM_013409 FST Hs00246256_m1 NM_006350 FST Hs00246260_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_000148 FUT1 Hs00355741_m1 NM_005031 FXYD1 Hs00245327_m1 NM_012193 FZD4 Hs00201853_m1 NM_003507 FZD7 Hs00275833_s1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 L13720 GAS6 Hs01090305_m1 NM_000820 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 NM_003644 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005261 GEM Hs00738924_m1 NM_005110 GFPT2 Hs01049561_m1 NM_004121 GGT5 Hs00269779_m1 107 NM_017655 GIPC2 Hs00214273_m1 NM_002060 GJA4 Hs00704917_s1 NM_002060 GJA4 Hs00704917_s1 NM_005270 GLI2 Hs00257977_m1 NM_032575 GLIS2 Hs00402743_g1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_015710 GLTSCR2 Hs00414236_m1 NM_004126 GNG11 Hs00914578_m1 NM_018841 GNG12 Hs03005750_m1 NM_053064 GNG2 Hs00828232_m1 NM_020918 GPAM Hs01573680_m1 NM_015234 GPR116 Hs00391810_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_198827 GPR133 Hs00914797_m1 NM_138445 GPR146 Hs00298904_s1 NM_014710 GPRASP1 Hs01932892_s1 NM_023927 GRAMD3 Hs00225077_m1 NM_022469 GREM2 Hs01934663_s1 NM_000177 GSN Hs00388617_m1 AF200715 GULP1 Hs00169604_m1 NM_016315 GULP1 Hs00169604_m1 NR_002196 H19 Hs00262142_g1 NR_002196 H19 Hs00262142_g1 NM_014571 HEYL Hs01113778_m1 NM_000601 HGF Hs00900066_m1 NM_002126 HLF Hs00171406_m1 M95585 HLF Hs00171406_m1 NM_002126 HLF Hs00171406_m1 NM_031935 HMCN1 Hs00399043_m1 NM_006895 HNMT Hs00199373_m1 NM_001024074 HNMT Hs02759756_s1 NM_030661 HOXA3 Hs00601076_m1 NM_019102 HOXA5 Hs00430330_m1 NM_016245 HSD17B11 Hs00212226_m1 NM_052970 HSPA12B Hs00369554_m1 NM_144617 HSPB6 Hs00328933_m1 M85289 HSPG2 Hs01078536_m1 NM_000867 HTR2B Hs00168362_m1 NM_002775 HTRA1 Hs01016151_m1 NM_002167 ID3 Hs00171409_m1 NM_001546 ID4 Hs00155465_m1 NM_001546 ID4 Hs00155465_m1 NM_020962 IGDCC4 Hs00326335_m1 108 M37484 IGF1 Hs01547657_m1 M29644 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_000612 IGF2 Hs00277496_s1 NM_001007139 IGF2 Hs00277496_s1 NM_001552 IGFBP4 Hs00181767_m1 NM_002178 IGFBP6 Hs00942697_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_144646 IGJ Hs00950678_g1 NM_178822 IGSF10 Hs00975906_m1 NM_004512 IL11RA Hs00234415_m1 NM_138284 IL17D Hs00370528_m1 NM_017563 IL17RD Hs00296982_m1 NM_000877 IL1R1 Hs00991002_m1 AB024518 IL33 Hs00369211_m1 AF128846 INMT Hs00198941_m1 NM_002194 INPP1 Hs00181856_m1 NM_006633 IQGAP2 Hs00183606_m1 AY009128 ISCU Hs00396806_m1 NM_005545 ISLR Hs01921558_s1 AF072132 ITGA7 Hs00174397_m1 NM_002206 ITGA7 Hs00174397_m1 NM_003638 ITGA8 Hs00233321_m1 NM_002210 ITGAV Hs00233808_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_030569 ITIH5 Hs00262393_s1 NM_004867 ITM2A Hs01011360_g1 NM_004867 ITM2A Hs01011360_g1 NM_021999 ITM2B Hs01126287_m1 AF114488 ITSN1 Hs00161676_m1 NM_001001132 ITSN1 Hs00161676_m1 AF114488 ITSN1 Hs00161676_m1 NM_000214 JAG1 Hs01070036_m1 NM_000214 JAG1 Hs01070036_m1 U73936 JAG1 Hs01070036_m1 NM_002227 JAK1 Hs01026996_m1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_002228 JUN Hs01103582_s1 109 NM_015493 KANK2 Hs00795260_m1 NM_138444 KCTD12 Hs00540818_s1 NM_138444 KCTD12 Hs00540818_s1 NM_007035 KERA Hs00559942_m1 NM_014686 KIAA0355 Hs00206664_m1 NM_014774 KIAA0494 Hs00207479_m1 NM_019590 KIAA1217 Hs00289569_m1 NM_018240 KIRREL Hs00217307_m1 NM_000222 KIT Hs00922202_m1 NM_005552 KLC1 Hs00194316_m1 NM_007249 KLF12 Hs00273134_m1 NM_016270 KLF2 Hs00360439_g1 NM_001206 KLF9 Hs00230918_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002290 LAMA4 Hs00935293_m1 M20206 LAMB1 Hs01055971_m1 NM_002291 LAMB1 Hs01055971_m1 NM_002293 LAMC1 Hs00267056_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_001290 LDB2 Hs00609711_m1 NM_001290 LDB2 Hs00609711_m1 U66495 LEPR Hs00900242_m1 U50748 LEPR Hs00900242_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_199000 LHFPL3 Hs01585188_s1 NM_002310 LIFR Hs01123581_m1 BC001247 LIMA1 Hs00212557_m1 NM_016357 LIMA1 Hs00212557_m1 NM_017980 LIMS2 Hs01002880_gH NM_153713 LIX1L Hs00542269_m1 NM_005574 LMO2 Hs00277106_m1 NM_012134 LMOD1 Hs00201704_m1 NM_002317 LOX Hs00942480_m1 NM_005576 LOXL1 Hs00935937_m1 NM_001401 LPAR1 Hs00173500_m1 NM_001401 LPAR1 Hs00173500_m1 NM_005767 LPAR6 Hs00271758_s1 NM_012302 LPHN2 Hs00202347_m1 NM_000237 LPL Hs01012571_m1 NM_000237 LPL Hs01012571_m1 110 NM_015116 LRCH1 Hs00996581_m1 NM_020871 LRCH2 Hs00325819_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_005824 LRRC17 Hs00180581_m1 NM_005512 LRRC32 Hs00194136_m1 NM_181506 LRRC70 Hs00704102_s1 BC004958 LRRFIP1 Hs00384213_m1 AL442092 LRRN3 Hs00539582_s1 NM_018334 LRRN3 Hs00539582_s1 AF113211 LTBP2 Hs00544640_s1 NM_000428 LTBP2 Hs00544640_s1 NM_002345 LUM Hs00158940_m1 NM_002345 LUM Hs00158940_m1 NM_005584 MAB21L1 Hs00366575_s1 NM_005461 MAFB Hs00271378_s1 NM_019066 MAGEL2 Hs00255922_s1 NM_153267 MAMDC2 Hs00299196_m1 NM_005907 MAN1A1 Hs00195458_m1 NM_005909 MAP1B Hs00195487_m1 NM_002380 MATN2 Hs00242767_m1 NM_002381 MATN3 Hs00159081_m1 NM_001002796 MCTP1 Hs00226801_m1 NM_005241 MECOM Hs00602795_m1 NM_005241 MECOM Hs00602795_m1 NM_002397 MEF2C Hs00231149_m1 NM_002397 MEF2C Hs00231149_m1 NM_002398 MEIS1 Hs01017441_m1 NM_004527 MEOX1 Hs00244943_m1 NM_005924 MEOX2 Hs00232248_m1 NM_014033 METTL7A Hs00204042_m1 NM_002404 MFAP4 Hs00412974_m1 AL136588 MMP16 Hs00540314_s1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 NM_007351 MMRN1 Hs00201182_m1 NM_024756 MMRN2 Hs00226971_m1 NM_024756 MMRN2 Hs00226971_m1 NM_002430 MN1 Hs00159202_m1 NM_024761 MOBKL2B Hs00257351_m1 NM_024761 MOBKL2B Hs00257351_m1 NM_023075 MPPE1 Hs00372745_g1 NM_006039 MRC2 Hs00195862_m1 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 111 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001001924 MTUS1 Hs00826834_m1 NM_205853 MUSTN1 Hs01592115_g1 AF245505 MXRA5 Hs00295630_s1 NM_032348 MXRA8 Hs00260584_m1 NM_025107 MYCT1 Hs00228305_m1 NM_002474 MYH11 Hs00224610_m1 NM_022844 MYH11 Hs00224622_m1 NM_006097 MYL9 Hs00697086_m1 NM_005467 NAALAD2 Hs01119919_m1 NM_052867 NALCN Hs00291166_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_005380 NBL1 Hs00185054_m1 NM_005380 NBL1 Hs00185054_m1 U35139 NDN Hs00267349_s1 NM_022351 NECAB1 Hs00332733_m1 NM_173808 NEGR1 Hs01584331_m1 NM_173808 NEGR1 Hs01584331_m1 NM_144573 NEXN Hs00332124_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_007361 NID2 Hs01547198_g1 BC005202 NIPSNAP3B Hs00218073_m1 NM_007184 NISCH Hs00200400_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_052946 NOSTRIN Hs00976555_m1 NM_024408 NOTCH2 Hs01050720_mH NM_024408 NOTCH2 Hs01050720_mH NM_002514 NOV Hs00159631_m1 NM_002514 NOV Hs00159631_m1 NM_153240 NPHP3 Hs00406109_m1 NM_153240 NPHP3 Hs00406109_m1 NM_003995 NPR2 Hs00241516_m1 BC004154 NR2F1 Hs00818842_m1 NM_005654 NR2F1 Hs00818842_m1 U01351 NR3C1 Hs00230818_m1 X03348 NR3C1 Hs00354508_m1 NM_016588 NRN1 Hs00213192_m1 NM_001024628 NRP1 Hs00826121_m1 AF278532 NTN4 Hs00221915_m1 NM_014840 NUAK1 Hs00934234_m1 NM_019094 NUDT4 Hs00819603_m1 NM_178507 OAF Hs00420156_m1 112 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_015441 OLFML2B Hs00827139_g1 NM_020190 OLFML3 Hs00220180_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_145260 OSR1 Hs00377071_m1 NM_182904 P4HA3 Hs00420085_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_017734 PALMD Hs00214675_m1 NM_001001991 PAMR1 Hs00405837_m1 NM_173462 PAPLN Hs00404545_m1 NM_057177 PARD3B Hs00365140_m1 AF237771 PARVA Hs00217177_m1 NM_018222 PARVA Hs00217177_m1 NM_019035 PCDH18 Hs00251855_m1 NM_019035 PCDH18 Hs00251855_m1 NM_002589 PCDH7 Hs00159908_m1 BC006439 PCDHGC3 Hs00251717_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_001003683 PDE1A Hs00192346_m1 NM_001003683 PDE1A Hs00192346_m1 NM_001003683 PDE1A Hs00192346_m1 NM_005019 PDE1A Hs00897273_m1 NM_002599 PDE2A Hs01042255_m1 NM_000921 PDE3A Hs01012698_m1 NM_000921 PDE3A Hs01012698_m1 NM_018945 PDE7B Hs01054008_m1 NM_016205 PDGFC Hs00211916_m1 AB033832 PDGFD Hs00937332_m1 NM_025208 PDGFD Hs00937332_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 NM_002612 PDK4 Hs01037704_m1 NM_021630 PDLIM2 Hs00222154_m1 AF338650 PDZD2 Hs00389477_m1 NM_015009 PDZRN3 Hs00392900_m1 M37780 PECAM1 Hs00169777_m1 NM_000442 PECAM1 Hs00169777_m1 113 NM_000442 PECAM1 Hs00169777_m1 NM_021255 PELI2 Hs01012262_mH NM_021965 PGM5 Hs00222671_m1 NM_015157 PHLDB1 Hs00384827_m1 NM_017933 PID1 Hs00952182_m1 NM_181504 PIK3R1 Hs00933163_m1 NM_000297 PKD2 Hs00165517_m1 NM_001007267 PLA2R1 Hs00234853_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_006718 PLAGL1 Hs00414677_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_015184 PLCL2 Hs00392897_m1 NM_172069 PLEKHH2 Hs01377275_m1 NM_002666 PLIN1 Hs01106927_m1 NM_002667 PLN Hs00160179_m1 NM_002667 PLN Hs00160179_m1 NM_005032 PLS3 Hs00192406_m1 NM_020353 PLSCR4 Hs00924823_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_020405 PLXDC1 Hs00220723_m1 L03203 PMP22 Hs00165556_m1 NM_153703 PODN Hs00542259_m1 D13665 POSTN Hs01566750_m1 AB000888 PPAP2A Hs00170356_m1 AF014403 PPAP2A Hs00170356_m1 AB000889 PPAP2B Hs00170359_m1 NM_003713 PPAP2B Hs00170359_m1 NM_003713 PPAP2B Hs00170359_m1 NM_000943 PPIC Hs00181460_m1 AF324888 PPP1R12B Hs00364082_m1 NM_021132 PPP3CB Hs00184176_m1 NM_012231 PRDM2 Hs00202013_m1 AF272898 PRDM6 Hs01373000_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_198859 PRICKLE2 Hs00291033_s1 NM_002742 PRKD1 Hs00177037_m1 NM_000313 PROS1 Hs00165590_m1 NM_024841 PRR5L Hs00757785_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 114 NM_000314 PTEN Hs01920652_s1 NM_000958 PTGER4 Hs00168761_m1 NM_020440 PTGFRN Hs01385989_m1 NM_000961 PTGIS Hs00919949_m1 M57399 PTN Hs00383235_m1 NM_002825 PTN Hs00383235_m1 BC005916 PTN Hs00383235_m1 NM_007039 PTPN21 Hs00234784_m1 NM_002837 PTPRB Hs01549049_m1 NM_002837 PTPRB Hs01549049_m1 NM_002841 PTPRG Hs00892788_m1 NM_002845 PTPRM Hs00267809_m1 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 NM_005859 PURA Hs00245886_s1 NM_006909 RASGRF2 Hs00394798_m1 NM_023940 RASL11B Hs00225132_m1 NM_016563 RASL12 Hs00275429_m1 NM_001031695 RBFOX2 Hs00329214_s1 NM_014483 RBMS3 Hs00205567_m1 NM_005822 RCAN2 Hs00195165_m1 NM_001268 RCBTB2 Hs00154390_m1 NM_021111 RECK Hs01019179_m1 NM_005045 RELN Hs01022646_m1 NM_144629 RFTN2 Hs00376096_m1 AF186779 RGL1 Hs00248508_m1 AF159570 RGS5 Hs00186212_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 AL136924 RIN2 Hs00610937_m1 NM_014746 RNF144A Hs00207267_m1 NM_178532 RNF180 Hs00400379_m1 NM_178532 RNF180 Hs00400379_m1 NM_019055 ROBO4 Hs00219408_m1 NM_001006932 RPS6KA2 Hs00179731_m1 D43968 RUNX1 Hs00231079_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001015051 RUNX2 Hs00298328_s1 NM_001400 S1PR1 Hs01922614_s1 NM_001030060 SAMD5 Hs02576346_m1 115 NM_173833 SCARA5 Hs01073151_m1 NM_173833 SCARA5 Hs01073151_m1 NM_153334 SCARF2 Hs00544847_m1 NM_004588 SCN2B Hs00190186_m1 AF225986 SCN3A Hs00366913_m1 NM_174934 SCN4B Hs00545394_m1 NM_002976 SCN7A Hs00161546_m1 NM_004657 SDPR Hs00190538_m1 NM_033127 SEC16B Hs00263939_m1 NM_003005 SELP Hs00356351_m1 NM_020163 SEMA3G Hs00220101_m1 NM_003966 SEMA5A Hs01549381_m1 NM_020858 SEMA6D Hs00227965_m1 NM_005410 SEPP1 Hs00193657_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_006216 SERPINE2 Hs00385730_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 NM_014454 SESN1 Hs00902787_m1 NM_003012 SFRP1 Hs03928965_s1 AF311912 SFRP2 Hs00293258_m1 NM_003013 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_031469 SH3BGRL2 Hs00230283_m1 NM_001009555 SH3D19 Hs00296942_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_001017995 SH3PXD2B Hs00375183_s1 AF022654 SHOX2 Hs00243203_m1 AL136944 SLC40A1 Hs00205888_m1 AF055585 SLIT2 Hs00191193_m1 NM_004787 SLIT2 Hs00191193_m1 AB011538 SLIT3 Hs00171524_m1 NM_003062 SLIT3 Hs00171524_m1 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 AB014737 SMOC2 Hs00405777_m1 NM_003068 SNAI2 Hs00950344_m1 NM_000345 SNCA Hs01103386_m1 NM_005460 SNCAIP Hs00193814_m1 116 NM_003099 SNX1 Hs00162052_m1 NM_018013 SOBP Hs00215979_m1 NM_003877 SOCS2 Hs00919620_m1 AL136896 SOCS5 Hs00367107_m1 NM_014011 SOCS5 Hs00751962_s1 NM_015385 SORBS1 Hs00908953_m1 NM_020777 SORCS2 Hs00325181_m1 NM_022454 SOX17 Hs00751752_s1 NM_022454 SOX17 Hs00751752_s1 NM_031439 SOX7 Hs00846731_s1 NM_003118 SPARC Hs00277762_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 AF231124 SPOCK1 Hs00270274_m1 AB051390 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_005841 SPRY1 Hs01083036_s1 NM_005842 SPRY2 Hs01921749_s1 NM_003128 SPTBN1 Hs01555159_m1 NM_006307 SRPX Hs00196867_m1 NM_005086 SSPN Hs00296706_s1 AL136756 SSPN Hs00296706_s1 NM_005086 SSPN Hs00296706_s1 NM_032528 ST6GAL2 Hs00290088_s1 NM_012448 STAT5B Hs00273500_m1 NM_003174 SVIL Hs00931028_m1 AB014540 SWAP70 Hs00296255_s1 AF043290 SYNE1 Hs00941972_m1 NM_007286 SYNPO Hs00702468_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_080737 SYTL4 Hs00299039_m1 NM_003182 TAC1 Hs00243227_m1 NM_006283 TACC1 Hs00180691_m1 NM_003186 TAGLN Hs00162558_m1 NM_003189 TAL1 Hs01097987_m1 NM_015079 TBC1D2B Hs00534954_m1 NM_152380 TBX15 Hs00537087_m1 NM_000192 TBX5 Hs00361155_m1 NM_152278 TCEAL7 Hs00385936_m1 117 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_000459 TEK Hs00945146_m1 NM_015319 TENC1 Hs00539247_m1 BC001830 TGFB1I1 Hs00210887_m1 J03241 TGFB3 Hs01086000_m1 NM_003243 TGFBR3 Hs01114250_m1 NM_003247 THBS2 Hs01568063_m1 NM_003248 THBS4 Hs00170261_m1 NM_018676 THSD1 Hs00218756_m1 NM_005424 TIE1 Hs00892696_m1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 NM_003257 TJP1 Hs00543824_m1 NM_004614 TK2 Hs00936918_m1 NM_007005 TLE4 Hs00276083_s1 AB002318 TLN2 Hs00322257_m1 NM_018286 TMEM100 Hs00388033_m1 NM_024600 TMEM204 Hs01061927_m1 AL136550 TMEM47 Hs00230190_m1 NM_022093 TNN Hs00295597_m1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 AF091627 TP63 Hs00978338_m1 NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_024164 TPSB2 Hs02576518_gH NM_003596 TPST1 Hs00234324_m1 NM_003295 TPT1 Hs02621289_g1 NM_003295 TPT1 Hs02621289_g1 NM_003295 TPT1 Hs02621289_g1 NM_003295 TPT1 Hs02621289_g1 118 NM_012288 TRAM2 Hs00202213_m1 NM_003304 TRPC1 Hs00608195_m1 NM_003304 TRPC1 Hs00608195_m1 NM_006022 TSC22D1 Hs01553786_m1 NM_173485 TSHZ2 Hs00251507_s1 NM_173485 TSHZ2 Hs00251507_s1 NM_173485 TSHZ2 Hs00251507_s1 NM_020856 TSHZ3 Hs02379784_s1 AL136805 TSHZ3 Hs02379784_s1 NM_005725 TSPAN2 Hs00194836_m1 NM_005725 TSPAN2 Hs00194836_m1 NM_004615 TSPAN7 Hs00190284_m1 AB028966 TTC28 Hs01117728_m1 NM_057179 TWIST2 Hs00382379_m1 NM_006472 TXNIP Hs01006900_g1 NM_001008224 UACA Hs00326052_m1 AF322916 UACA Hs00326052_m1 NM_007106 UBL3 Hs01018736_g1 NM_007124 UTRN Hs01126016_m1 D32039 VCAN Hs01007941_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_003380 VIM Hs00958116_m1 NM_015378 VPS13D Hs00390189_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_000552 VWF Hs00169795_m1 NM_014991 WDFY3 Hs00385595_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003881 WISP2 Hs00180242_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_015472 WWTR1 Hs00210007_m1 NM_015472 WWTR1 Hs00210007_m1 NM_006106 YAP1 Hs00371735_m1 NM_015642 ZBTB20 Hs00210321_m1 NM_015642 ZBTB20 Hs00210321_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_030751 ZEB1 Hs01566407_m1 U12170 ZEB1 Hs01566407_m1 119 NM_014795 ZEB2 Hs00207691_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_024721 ZFHX4 Hs00257312_s1 NM_022473 ZFP106 Hs00223868_m1 NM_003407 ZFP36 Hs00185658_m1 NM_004926 ZFP36L1 Hs00245183_m1 NM_006887 ZFP36L2 Hs00272828_m1 NM_006887 ZFP36L2 Hs00272828_m1 NM_012082 ZFPM2 Hs00201397_m1 NM_017661 ZNF280D Hs00214302_m1 NM_015069 ZNF423 Hs00323880_m1 NM_030634 ZNF436 Hs00535922_m1 NM_030634 ZNF436 Hs00535922_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 COL1A1 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_005157 ABL1 Hs01104721_m1 NM_001613 ACTA2 Hs00426835_g1 M95178 ACTN1 Hs00998100_m1 BC003576 ACTN1 Hs00998100_m1 NM_001102 ACTN1 Hs00998100_m1 NM_001105 ACVR1 Hs00153836_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_139056 ADAMTS16 Hs01049997_m1 NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_197941 ADAMTS6 Hs00812159_s1 AF284095 ADRA2A Hs00265081_s1 NM_001129 AEBP1 Hs00937468_m1 AB003476 AKAP12 Hs00374507_m1 NM_001034173 ALDH1L2 Hs00402876_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 120 NM_004308 ARHGAP1 Hs00188815_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_018071 ARHGEF40 Hs00216283_m1 AF316824 ASPN Hs00214395_m1 NM_017680 ASPN Hs00214395_m1 NM_000332 ATXN1 Hs00165656_m1 NM_021913 AXL Hs01064444_m1 NM_012104 BACE1 Hs01123242_m1 NM_152731 BEND6 Hs00288163_m1 NM_001711 BGN Hs00959143_m1 NM_001711 BGN Hs00959143_m1 BC002416 BGN Hs00959143_m1 NM_017614 BHMT2 Hs00214120_m1 NM_006129 BMP1 Hs00196183_m1 NM_001199 BMP1 Hs00986789_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_030945 C1QTNF3 Hs00229569_m1 AF329841 C1QTNF5 Hs00363053_g1 NM_031910 C1QTNF6 Hs00230464_m1 AF329842 C1QTNF6 Hs00230464_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 NM_004772 C5orf13 Hs00854282_g1 NM_004772 C5orf13 Hs00854282_g1 AF313413 C5orf62 Hs00383944_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_025140 CCDC92 Hs00228468_m1 NM_020404 CD248 Hs00535586_s1 NM_001024736 CD276 Hs00987207_m1 NM_002414 CD99 Hs00365982_m1 U82164 CD99 Hs00242853_m1 NM_002414 CD99 Hs00365982_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 121 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_004936 CDKN2B Hs00793225_m1 NM_016174 CERCAM Hs00170969_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_175856 CHSY3 Hs00545664_m1 NM_003613 CILP Hs00173647_m1 D86586 CLEC11A Hs00161544_m1 NM_002975 CLEC11A Hs00161544_m1 BC005810 CLEC11A Hs00161544_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 NM_004368 CNN2 Hs00854264_s1 NM_015463 CNRIP1 Hs00384403_m1 NM_000493 COL10A1 Hs00166657_m1 NM_000493 COL10A1 Hs00166657_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 NM_001856 COL16A1 Hs00156876_m1 AF018081 COL18A1 Hs01043425_g1 NM_030582 COL18A1 Hs01043425_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 NM_000393 COL5A2 Hs00893923_m1 NM_015719 COL5A3 Hs00210526_m1 NM_015719 COL5A3 Hs00210526_m1 NM_001848 COL6A1 Hs00242448_m1 122 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001849 COL6A2 Hs00242484_m1 AY029208 COL6A2 Hs00242484_m1 NM_004369 COL6A3 Hs00915120_m1 NM_001850 COL8A1 Hs00156669_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_000095 COMP Hs00164359_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_001864 COX7A1 Hs00156989_m1 NM_019609 CPXM1 Hs01566704_g1 BC006393 CPZ Hs00186333_m1 NM_052854 CREB3L1 Hs00999635_m1 AL136861 CRISPLD2 Hs00230322_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_138455 CTHRC1 Hs00298917_m1 NM_000396 CTSK Hs00166156_m1 NM_000609 CXCL12 Hs00930455_m1 AF003114 CYR61 Hs00998503_g1 NM_001554 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 BC003064 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_003737 DCHS1 Hs01044548_m1 AF138303 DCN Hs00266491_m1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_001920 DCN Hs00754870_s1 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_006182 DDR2 Hs01025953_m1 NM_013989 DIO2 Hs00255341_m1 NM_014974 DIP2C Hs00324224_m1 NM_013253 DKK3 Hs00247429_m1 123 NM_001018057 DKK3 Hs00247429_m1 NM_001005336 DNM1 Hs00189369_m1 NM_001937 DPT Hs00355056_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_013352 DSE Hs00203441_m1 NM_001393 ECM2 Hs00154821_m1 NM_005711 EDIL3 Hs00174781_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_016938 EFEMP2 Hs00213545_m1 AB030655 EFEMP2 Hs00213545_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_005230 ELK3 Hs00987814_m1 NM_000501 ELN Hs01091772_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_001425 EMP3 Hs00171319_m1 NM_004098 EMX2 Hs00244574_m1 NM_001776 ENTPD1 Hs00739960_s1 NM_004956 ETV1 Hs00290469_s1 NM_000129 F13A1 Hs00173388_m1 NM_001992 F2R Hs00169258_m1 NM_004101 F2RL2 Hs00187982_m1 NM_182705 FAM101B Hs00823804_m1 NM_182705 FAM101B Hs00823804_m1 NM_153711 FAM26E Hs00382139_m1 U76833 FAP Hs00990806_m1 NM_001996 FBLN1 Hs00242546_m1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 NM_003862 FGF18 Hs00818572_m1 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 NM_014890 FILIP1L Hs00706279_s1 NM_017946 FKBP14 Hs00942521_m1 124 NM_017946 FKBP14 Hs00942521_m1 AF100751 FKBP7 Hs00535040_m1 NM_007270 FKBP9 Hs00414859_m1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_013231 FLRT2 Hs00544171_s1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 BC005858 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 AF130095 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_032532 FNDC1 Hs00287359_m1 NM_005253 FOSL2 Hs00232013_m1 NM_005253 FOSL2 Hs00232013_m1 NM_005253 FOSL2 Hs00232013_m1 NM_001452 FOXF2 Hs00230963_m1 NM_152330 FRMD6 Hs00378563_m1 NM_152330 FRMD6 Hs00378563_m1 NM_013409 FST Hs00246256_m1 NM_006350 FST Hs00246260_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_003505 FZD1 Hs00268943_s1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 L13720 GAS6 Hs01090305_m1 NM_000820 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 NM_003644 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005110 GFPT2 Hs01049561_m1 NM_004121 GGT5 Hs00269779_m1 M86849 GJB2 Hs00269615_s1 NM_005270 GLI2 Hs00257977_m1 NM_032575 GLIS2 Hs00402743_g1 NM_152629 GLIS3 Hs00295084_s1 NM_152629 GLIS3 Hs00295084_s1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_014498 GOLIM4 Hs00274320_m1 125 AF111178 GPC6 Hs00170677_m1 NM_005708 GPC6 Hs00170677_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_001008397 GPX8 Hs00380670_m1 AF154054 GREM1 Hs00171951_m1 NM_013372 GREM1 Hs00171951_m1 NM_002091 GRP Hs00181852_m1 NR_002196 H19 Hs00262142_g1 NR_002196 H19 Hs00262142_g1 NM_014799 HEPH Hs00953259_m1 NM_014571 HEYL Hs01113778_m1 NM_031935 HMCN1 Hs00399043_m1 NM_003725 HSD17B6 Hs00366258_m1 NM_003725 HSD17B6 Hs00366258_m1 NM_052970 HSPA12B Hs00369554_m1 NM_005529 HSPG2 Hs01078536_m1 M85289 HSPG2 Hs01078536_m1 NM_002775 HTRA1 Hs01016151_m1 NM_053044 HTRA3 Hs01099710_m1 NM_053044 HTRA3 Hs01099710_m1 BC002857 IFFO1 Hs00209967_m1 NM_020962 IGDCC4 Hs00326335_m1 NM_000612 IGF2 Hs00277496_s1 NM_001007139 IGF2 Hs00277496_s1 NM_001552 IGFBP4 Hs00181767_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_000877 IL1R1 Hs00991002_m1 NM_004517 ILK Hs00177914_m1 NM_002192 INHBA Hs01081598_m1 M13436 INHBA Hs01081598_m1 NM_005545 ISLR Hs01921558_s1 AF109681 ITGA11 Hs01012939_m1 NM_002205 ITGA5 Hs01547673_m1 NM_002210 ITGAV Hs00233808_m1 NM_002211 ITGB1 Hs00236976_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_032801 JAM3 Hs00262270_s1 NM_015493 KANK2 Hs00795260_m1 NM_181712 KANK4 Hs00400916_m1 126 AF160967 KCNMB4 Hs00205704_m1 NM_024089 KDELC1 Hs00607574_g1 NM_007035 KERA Hs00559942_m1 NM_018689 KIAA1199 Hs00378530_m1 NM_019590 KIAA1217 Hs00289569_m1 NM_018012 KIF26B Hs00215977_m1 NM_018240 KIRREL Hs00217307_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002290 LAMA4 Hs00935293_m1 M20206 LAMB1 Hs01055971_m1 NM_002291 LAMB1 Hs01055971_m1 NM_002293 LAMC1 Hs00267056_m1 AF207547 LATS2 Hs00324396_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_022356 LEPRE1 Hs00223565_m1 NM_002305 LGALS1 Hs00355202_m1 NM_005780 LHFP Hs00172961_m1 NM_199000 LHFPL3 Hs01585188_s1 NM_016357 LIMA1 Hs00212557_m1 NM_014583 LMCD1 Hs00205871_m1 NM_002317 LOX Hs00942480_m1 NM_002317 LOX Hs00942480_m1 NM_005576 LOXL1 Hs00935937_m1 NM_002318 LOXL2 Hs00158757_m1 NM_001401 LPAR1 Hs00173500_m1 NM_020871 LRCH2 Hs00325819_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_130830 LRRC15 Hs00370056_s1 NM_005824 LRRC17 Hs00180581_m1 NM_005512 LRRC32 Hs00194136_m1 AF113211 LTBP2 Hs00544640_s1 NM_000428 LTBP2 Hs00544640_s1 NM_002345 LUM Hs00158940_m1 NM_002345 LUM Hs00158940_m1 NM_005461 MAFB Hs00271378_s1 NM_005461 MAFB Hs00271378_s1 NM_019066 MAGEL2 Hs00255922_s1 NM_002373 MAP1A Hs00357973_m1 M64571 MAP4 Hs00159048_m1 NM_004834 MAP4K4 Hs00377415_m1 BC004995 MARVELD1 Hs00230362_m1 127 NM_002381 MATN3 Hs00159081_m1 NM_017459 MFAP2 Hs01027737_m1 NM_002404 MFAP4 Hs00412974_m1 U37283 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_014632 MICAL2 Hs01121806_m1 NM_014632 MICAL2 Hs01121806_m1 NM_000248 MITF Hs01117294_m1 NM_005940 MMP11 Hs00171829_m1 NM_005940 MMP11 Hs00171829_m1 NM_002427 MMP13 Hs00942589_m1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 AL136588 MMP16 Hs00540314_s1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 NM_002430 MN1 Hs00159202_m1 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 AF245505 MXRA5 Hs00295630_s1 NM_001008528 MXRA7 Hs00895155_m1 NM_032348 MXRA8 Hs00260584_m1 NM_002473 MYH9 Hs00159522_m1 NM_006097 MYL9 Hs00697086_m1 NM_015194 MYO1D Hs00381456_m1 NM_052867 NALCN Hs00291166_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_005380 NBL1 Hs00185054_m1 NM_005380 NBL1 Hs00185054_m1 U35139 NDN Hs00267349_s1 NM_173808 NEGR1 Hs01584331_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_007361 NID2 Hs01547198_g1 NM_016533 NINJ2 Hs00356576_m1 NM_033120 NKD2 Hs00263909_m1 NM_001189 NKX3-2 Hs00154168_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 128 NM_016931 NOX4 Hs01558199_m1 NM_001024628 NRP1 Hs00826121_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_002526 NT5E Hs01573922_m1 NM_016522 NTM Hs00275411_m1 NM_016522 NTM Hs00275411_m1 NM_014840 NUAK1 Hs00934234_m1 NM_019094 NUDT4 Hs00819603_m1 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_015441 OLFML2B Hs00827139_g1 NM_020190 OLFML3 Hs00220180_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_182904 P4HA3 Hs00420085_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_000919 PAM Hs00168596_m1 NM_000919 PAM Hs00168596_m1 AF237771 PARVA Hs00217177_m1 NM_018222 PARVA Hs00217177_m1 AB006757 PCDH7 Hs00361092_m1 NM_002589 PCDH7 Hs00159908_m1 AF152318 PCDHGA1 Hs00251717_m1 NM_002588 PCDHGC3 Hs00251717_m1 BC006439 PCDHGC3 Hs00251717_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_016205 PDGFC Hs00211916_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 NM_021630 PDLIM2 Hs00222154_m1 NM_005451 PDLIM7 Hs01103929_g1 NM_005451 PDLIM7 Hs01103929_g1 NM_001006624 PDPN Hs01089982_g1 NM_006474 PDPN Hs01089982_g1 NM_001006624 PDPN Hs01089982_g1 NM_015157 PHLDB1 Hs00384827_m1 129 NM_000297 PKD2 Hs00165517_m1 K03226 PLAU Hs00170182_m1 NM_002658 PLAU Hs00170182_m1 AY029180 PLAUR Hs00959822_m1 U08839 PLAUR Hs00182181_m1 NM_005032 PLS3 Hs00192406_m1 NM_020353 PLSCR4 Hs00924823_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_032812 PLXDC2 Hs00262350_m1 NM_005761 PLXNC1 Hs00955621_m1 NM_020182 PMEPA1 Hs03987603_g1 NM_020182 PMEPA1 Hs03987603_g1 NM_020182 PMEPA1 Hs03987603_g1 L03203 PMP22 Hs00165556_m1 NM_153703 PODN Hs00542259_m1 NM_006475 POSTN Hs01566750_m1 D13665 POSTN Hs01566750_m1 NM_001030059 PPAPDC1A Hs00404185_m1 NM_000943 PPIC Hs00181460_m1 NM_000943 PPIC Hs00181460_m1 AF272898 PRDM6 Hs01373000_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_198859 PRICKLE2 Hs00291033_s1 NM_145040 PRKCDBP Hs00293638_m1 NM_002742 PRKD1 Hs00177037_m1 NM_024841 PRR5L Hs00757785_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_020440 PTGFRN Hs01385989_m1 NM_002821 PTK7 Hs00897151_m1 NM_007039 PTPN21 Hs00234784_m1 NM_002839 PTPRD Hs00295441_s1 NM_002839 PTPRD Hs00295441_s1 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 AF183421 RAB31 Hs00199313_m1 NM_006868 RAB31 Hs00199313_m1 NM_006868 RAB31 Hs00199313_m1 NM_015577 RAI14 Hs00210238_m1 BC000069 RARRES2 Hs00161209_g1 NM_006909 RASGRF2 Hs00394798_m1 NM_020650 RCN3 Hs00276633_m1 NM_020650 RCN3 Hs00276633_m1 130 NM_021111 RECK Hs01019179_m1 NM_017821 RHBDL2 Hs00384848_m1 AL136924 RIN2 Hs00610937_m1 NM_014746 RNF144A Hs00207267_m1 NM_004560 ROR2 Hs00896176_m1 NM_001006932 RPS6KA2 Hs00179731_m1 D43968 RUNX1 Hs00231079_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001015051 RUNX2 Hs00298328_s1 NM_001015051 RUNX2 Hs00298328_s1 NM_002968 SALL1 Hs00231307_m1 NM_002968 SALL1 Hs00231307_m1 NM_020436 SALL4 Hs00360675_m1 NM_153334 SCARF2 Hs00544847_m1 NM_001006946 SDC1 Hs00896425_g1 NM_006364 SEC23A Hs00197232_m1 AB020712 SEC31A Hs00274601_m1 NM_014933 SEC31A Hs00274601_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 AF311912 SFRP2 Hs00293258_m1 NM_003013 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_032291 SGIP1 Hs00260297_m1 AL136561 SGIP1 Hs00260297_m1 NM_001009555 SH3D19 Hs00296942_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_001017995 SH3PXD2B Hs00375183_s1 NM_006884 SHOX2 Hs01059691_m1 AF022654 SHOX2 Hs00243203_m1 NM_033518 SLC38A5 Hs01012028_m1 NM_152264 SLC39A13 Hs00378317_m1 AF055585 SLIT2 Hs00191193_m1 NM_003062 SLIT3 Hs00171524_m1 131 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 NM_003068 SNAI2 Hs00950344_m1 NM_020777 SORCS2 Hs00325181_m1 NM_003118 SPARC Hs00277762_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_015535 SPATS2L Hs00274702_m1 NM_021972 SPHK1 Hs00184211_m1 AF231124 SPOCK1 Hs00270274_m1 AB051390 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_025106 SPSB1 Hs00228304_m1 NM_025106 SPSB1 Hs00228304_m1 NM_006307 SRPX Hs00196867_m1 NM_014467 SRPX2 Hs00997580_m1 NM_018984 SSH1 Hs00368014_m1 AL136756 SSPN Hs00296706_s1 NM_005086 SSPN Hs00296706_s1 NM_005418 ST5 Hs00936461_m1 NM_032528 ST6GAL2 Hs00290088_s1 NM_015170 SULF1 Hs00290918_m1 NM_015170 SULF1 Hs00290918_m1 NM_015170 SULF1 Hs00290918_m1 NM_018837 SULF2 Hs00378697_m1 NM_018837 SULF2 Hs00378697_m1 NM_033025 SYDE1 Hs00263581_m1 NM_024893 SYNDIG1 Hs00227616_m1 NM_007286 SYNPO Hs00702468_s1 NM_080737 SYTL4 Hs00299039_m1 NM_003186 TAGLN Hs00162558_m1 NM_014604 TAX1BP3 Hs00205924_m1 AF234997 TAX1BP3 Hs00205924_m1 NM_152380 TBX15 Hs00537087_m1 NM_000192 TBX5 Hs00361155_m1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 132 BC000125 TGFB1 Hs00998133_m1 BC001830 TGFB1I1 Hs00210887_m1 J03241 TGFB3 Hs01086000_m1 NM_000358 TGFBI Hs03987596_s1 NM_003246 THBS1 Hs00962914_m1 NM_003247 THBS2 Hs01568063_m1 NM_006288 THY1 Hs00264235_s1 NM_006288 THY1 Hs00264235_s1 AL161958 THY1 Hs00264235_s1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 U67195 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_024600 TMEM204 Hs01061927_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_018647 TNFRSF19 Hs00218634_m1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_003289 TPM2 Hs00268540_m1 NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_024164 TPSB2 Hs02576518_gH NM_012288 TRAM2 Hs00202213_m1 NM_003304 TRPC1 Hs00608195_m1 NM_003304 TRPC1 Hs00608195_m1 NM_020856 TSHZ3 Hs02379784_s1 AL136805 TSHZ3 Hs02379784_s1 NM_000474 TWIST1 Hs00361186_m1 NM_057179 TWIST2 Hs00382379_m1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 D32039 VCAN Hs01007941_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_014000 VCL Hs00243320_m1 NM_016206 VGLL3 Hs00275109_s1 NM_003380 VIM Hs00958116_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 133 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003881 WISP2 Hs00180242_m1 NM_001002292 WLS Hs01553062_m1 NM_003391 WNT2 Hs00608224_m1 NM_003392 WNT5A Hs00998537_m1 NM_015472 WWTR1 Hs00210007_m1 NM_145166 ZBTB47 Hs00908860_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_030751 ZEB1 Hs01566407_m1 U12170 ZEB1 Hs01566407_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_024721 ZFHX4 Hs00257312_s1 NM_012082 ZFPM2 Hs00201397_m1 NM_015069 ZNF423 Hs00323880_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 NM_024706 ZNF668 Hs00226767_m1 NM_003461 ZYX Hs00170299_m1 COL6A1 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_005157 ABL1 Hs01104721_m1 NM_001613 ACTA2 Hs00426835_g1 NM_001101 ACTB Hs03023880_g1 NM_001102 ACTN1 Hs00998100_m1 M95178 ACTN1 Hs00998100_m1 BC003576 ACTN1 Hs00998100_m1 NM_001105 ACVR1 Hs00153836_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_139056 ADAMTS16 Hs01049997_m1 NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_197941 ADAMTS6 Hs00812159_s1 134 NM_052998 ADC Hs00364871_m1 AF284095 ADRA2A Hs00265081_s1 NM_001129 AEBP1 Hs00937468_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_006738 AKAP13 Hs00331658_s1 NM_005465 AKT3 Hs00289302_s1 NM_001034173 ALDH1L2 Hs00402876_m1 NM_130847 AMOTL1 Hs00294070_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_054027 ANKH Hs00219798_m1 NM_054027 ANKH Hs00219798_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_153000 APCDD1 Hs00537787_m1 NM_004308 ARHGAP1 Hs00188815_m1 NM_004308 ARHGAP1 Hs00188815_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_005737 ARL4C Hs00255039_s1 NM_005737 ARL4C Hs00255039_s1 NM_000047 ARSE Hs01033722_m1 NM_017680 ASPN Hs00214395_m1 AF316824 ASPN Hs00214395_m1 NM_001007026 ATN1 Hs00157312_m1 NM_021913 AXL Hs01064444_m1 NM_012104 BACE1 Hs01123242_m1 NM_152731 BEND6 Hs00288163_m1 BC002416 BGN Hs00959143_m1 NM_001711 BGN Hs00959143_m1 NM_001711 BGN Hs00959143_m1 NM_017614 BHMT2 Hs00214120_m1 NM_017614 BHMT2 Hs00214120_m1 NM_006129 BMP1 Hs00196183_m1 NM_001199 BMP1 Hs00986789_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 135 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_030968 C1QTNF1 Hs00945123_m1 NM_030945 C1QTNF3 Hs00229569_m1 AF329841 C1QTNF5 Hs00363053_g1 NM_031910 C1QTNF6 Hs00230464_m1 AF329842 C1QTNF6 Hs00230464_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 NM_004772 C5orf13 Hs00854282_g1 AF313413 C5orf62 Hs00383944_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 BC000039 CALHM2 Hs00374996_m1 NM_001219 CALU Hs00154230_m1 NM_001753 CAV1 Hs00971716_m1 NM_001753 CAV1 Hs00971716_m1 NM_032040 CCDC8 Hs00540204_s1 AL136609 CCDC8 Hs00540204_s1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_025140 CCDC92 Hs00228468_m1 NM_001759 CCND2 Hs00922419_g1 NM_020404 CD248 Hs00535586_s1 NM_001024736 CD276 Hs00987207_m1 NM_012072 CD93 Hs00362607_m1 NM_002414 CD99 Hs00365982_m1 NM_002414 CD99 Hs00365982_m1 U82164 CD99 Hs00242853_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_016174 CERCAM Hs00170969_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_003956 CH25H Hs02379634_s1 NM_024536 CHPF Hs00226041_m1 NM_018413 CHST11 Hs00218229_m1 136 NM_175856 CHSY3 Hs00545664_m1 NM_003613 CILP Hs00173647_m1 D86586 CLEC11A Hs00161544_m1 NM_002975 CLEC11A Hs00161544_m1 BC005810 CLEC11A Hs00161544_m1 NM_015526 CLIP3 Hs00367493_m1 NM_024769 CLMP Hs00956750_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 NM_004368 CNN2 Hs00854264_s1 NM_015463 CNRIP1 Hs00384403_m1 U07820 CNTN1 Hs00169986_m1 NM_000493 COL10A1 Hs00166657_m1 NM_000493 COL10A1 Hs00166657_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 NM_001856 COL16A1 Hs00156876_m1 AF018081 COL18A1 Hs01043425_g1 NM_030582 COL18A1 Hs01043425_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_001846 COL4A2 Hs01098873_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 NM_000393 COL5A2 Hs00893923_m1 NM_015719 COL5A3 Hs00210526_m1 NM_015719 COL5A3 Hs00210526_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 137 NM_001849 COL6A2 Hs00242484_m1 AY029208 COL6A2 Hs00242484_m1 NM_004369 COL6A3 Hs00915120_m1 NM_001850 COL8A1 Hs00156669_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_000095 COMP Hs00164359_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_001864 COX7A1 Hs00156989_m1 NM_019609 CPXM1 Hs01566704_g1 BC006393 CPZ Hs00186333_m1 AL136861 CRISPLD2 Hs00230322_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_138455 CTHRC1 Hs00298917_m1 NM_000396 CTSK Hs00166156_m1 NM_000609 CXCL12 Hs00930455_m1 NM_000398 CYB5R3 Hs00240921_m1 NM_134268 CYGB Hs00370478_m1 NM_001554 CYR61 Hs00998503_g1 AF003114 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 NM_001343 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 BC003064 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_003737 DCHS1 Hs01044548_m1 NM_001920 DCN Hs00754870_s1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 AF138303 DCN Hs00266491_m1 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_006182 DDR2 Hs01025953_m1 NM_013989 DIO2 Hs00255341_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 NM_006094 DLC1 Hs00183436_m1 AF026219 DLC1 Hs00931487_m1 NM_001005336 DNM1 Hs00189369_m1 138 NM_001935 DPP4 Hs00175210_m1 M74777 DPP4 Hs00175210_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_013352 DSE Hs00203441_m1 NM_014934 DZIP1 Hs00208790_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_001393 ECM2 Hs00154821_m1 NM_005711 EDIL3 Hs00174781_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_016938 EFEMP2 Hs00213545_m1 AB030655 EFEMP2 Hs00213545_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_000501 ELN Hs01091772_m1 NM_000501 ELN Hs01091772_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_001425 EMP3 Hs00171319_m1 NM_004098 EMX2 Hs00244574_m1 NM_001776 ENTPD1 Hs00739960_s1 NM_147127 EVC2 Hs00377633_m1 NM_000129 F13A1 Hs00173388_m1 NM_001992 F2R Hs00169258_m1 NM_004101 F2RL2 Hs00187982_m1 NM_182705 FAM101B Hs00823804_m1 NM_182705 FAM101B Hs00823804_m1 NM_020223 FAM20C Hs00398243_m1 NM_153711 FAM26E Hs00382139_m1 NM_024519 FAM65A Hs00225927_m1 U76833 FAP Hs00990806_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 139 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_006832 FERMT2 Hs01041255_m1 Z24725 FERMT2 Hs01041255_m1 NM_006832 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 NM_003862 FGF18 Hs00818572_m1 AF063002 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 NM_004468 FHL3 Hs00189516_m1 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 NM_014890 FILIP1L Hs00706279_s1 NM_017946 FKBP14 Hs00942521_m1 AF100751 FKBP7 Hs00535040_m1 NM_007270 FKBP9 Hs00414859_m1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_001458 FLNC Hs00155124_m1 NM_013231 FLRT2 Hs00544171_s1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 BC005858 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 AF130095 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_032532 FNDC1 Hs00287359_m1 NM_005253 FOSL2 Hs00232013_m1 NM_005253 FOSL2 Hs00232013_m1 NM_005253 FOSL2 Hs00232013_m1 NM_001452 FOXF2 Hs00230963_m1 NM_005197 FOXN3 Hs00830558_g1 NM_152330 FRMD6 Hs00378563_m1 NM_152330 FRMD6 Hs00378563_m1 NM_003088 FSCN1 Hs00979631_g1 NM_006350 FST Hs00246260_m1 NM_013409 FST Hs00246256_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_000148 FUT1 Hs00355741_m1 NM_003505 FZD1 Hs00268943_s1 140 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 NM_002048 GAS1 Hs00266715_s1 L13720 GAS6 Hs01090305_m1 NM_000820 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005110 GFPT2 Hs01049561_m1 NM_004121 GGT5 Hs00269779_m1 M86849 GJB2 Hs00269615_s1 NM_012201 GLG1 Hs00953976_s1 NM_005270 GLI2 Hs00257977_m1 NM_032575 GLIS2 Hs00402743_g1 NM_152629 GLIS3 Hs00295084_s1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_005708 GPC6 Hs00170677_m1 NM_002510 GPNMB Hs01095679_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_015696 GPX7 Hs00210410_m1 NM_001008397 GPX8 Hs00380670_m1 AF154054 GREM1 Hs00171951_m1 NM_013372 GREM1 Hs00171951_m1 NM_002091 GRP Hs00181852_m1 NM_000177 GSN Hs00388617_m1 NR_002196 H19 Hs00262142_g1 NM_014799 HEPH Hs00953259_m1 NM_014571 HEYL Hs01113778_m1 NM_031935 HMCN1 Hs00399043_m1 NM_052970 HSPA12B Hs00369554_m1 NM_005529 HSPG2 Hs01078536_m1 M85289 HSPG2 Hs01078536_m1 NM_002775 HTRA1 Hs01016151_m1 NM_053044 HTRA3 Hs01099710_m1 NM_053044 HTRA3 Hs01099710_m1 NM_002167 ID3 Hs00171409_m1 BC002857 IFFO1 Hs00209967_m1 NM_020962 IGDCC4 Hs00326335_m1 NM_000618 IGF1 Hs01547657_m1 NM_000612 IGF2 Hs00277496_s1 NM_001007139 IGF2 Hs00277496_s1 141 NM_000598 IGFBP3 Hs00426289_m1 NM_001552 IGFBP4 Hs00181767_m1 NM_002178 IGFBP6 Hs00942697_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_000877 IL1R1 Hs00991002_m1 NM_004517 ILK Hs00177914_m1 NM_002192 INHBA Hs01081598_m1 M13436 INHBA Hs01081598_m1 NM_005545 ISLR Hs01921558_s1 AF109681 ITGA11 Hs01012939_m1 NM_002205 ITGA5 Hs01547673_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_015493 KANK2 Hs00795260_m1 NM_181712 KANK4 Hs00400916_m1 AF160967 KCNMB4 Hs00205704_m1 NM_138444 KCTD12 Hs00540818_s1 NM_024089 KDELC1 Hs00607574_g1 NM_007035 KERA Hs00559942_m1 NM_019590 KIAA1217 Hs00289569_m1 NM_018012 KIF26B Hs00215977_m1 NM_018240 KIRREL Hs00217307_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002290 LAMA4 Hs00935293_m1 NM_002291 LAMB1 Hs01055971_m1 M20206 LAMB1 Hs01055971_m1 NM_002293 LAMC1 Hs00267056_m1 AF207547 LATS2 Hs00324396_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_022356 LEPRE1 Hs00223565_m1 NM_002305 LGALS1 Hs00355202_m1 NM_005780 LHFP Hs00172961_m1 NM_199000 LHFPL3 Hs01585188_s1 NM_153713 LIX1L Hs00542269_m1 NM_014583 LMCD1 Hs00205871_m1 NM_005572 LMNA Hs01108898_g1 NM_012134 LMOD1 Hs00201704_m1 NM_002317 LOX Hs00942480_m1 142 NM_002317 LOX Hs00942480_m1 NM_005576 LOXL1 Hs00935937_m1 NM_002318 LOXL2 Hs00158757_m1 NM_002318 LOXL2 Hs00158757_m1 NM_015116 LRCH1 Hs00996581_m1 NM_020871 LRCH2 Hs00325819_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_130830 LRRC15 Hs00370056_s1 NM_005824 LRRC17 Hs00180581_m1 NM_005512 LRRC32 Hs00194136_m1 NM_002339 LSP1 Hs00158886_m1 AF113211 LTBP2 Hs00544640_s1 NM_000428 LTBP2 Hs00544640_s1 NM_002345 LUM Hs00158940_m1 NM_002345 LUM Hs00158940_m1 NM_033631 LUZP1 Hs00612276_m1 NM_005461 MAFB Hs00271378_s1 NM_005461 MAFB Hs00271378_s1 NM_019066 MAGEL2 Hs00255922_s1 NM_002373 MAP1A Hs00357973_m1 NM_002375 MAP4 Hs00159048_m1 M64571 MAP4 Hs00159048_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_004834 MAP4K4 Hs00377415_m1 BC004995 MARVELD1 Hs00230362_m1 NM_017459 MFAP2 Hs01027737_m1 NM_002404 MFAP4 Hs00412974_m1 NM_003480 MFAP5 Hs00185803_m1 U37283 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_014632 MICAL2 Hs01121806_m1 NM_014632 MICAL2 Hs01121806_m1 NM_005940 MMP11 Hs00171829_m1 NM_005940 MMP11 Hs00171829_m1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 AL136588 MMP16 Hs00540314_s1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 NM_002430 MN1 Hs00159202_m1 NM_006039 MRC2 Hs00195862_m1 143 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 AF060154 MSC Hs00231955_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 AF245505 MXRA5 Hs00295630_s1 NM_001008528 MXRA7 Hs00895155_m1 NM_001008528 MXRA7 Hs00895155_m1 NM_032348 MXRA8 Hs00260584_m1 NM_002473 MYH9 Hs00159522_m1 NM_006097 MYL9 Hs00697086_m1 NM_015194 MYO1D Hs00381456_m1 NM_004998 MYO1E Hs00192232_m1 NM_052867 NALCN Hs00291166_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_005380 NBL1 Hs00185054_m1 NM_005380 NBL1 Hs00185054_m1 U35139 NDN Hs00267349_s1 NM_173808 NEGR1 Hs01584331_m1 NM_173808 NEGR1 Hs01584331_m1 NM_144573 NEXN Hs00332124_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_007361 NID2 Hs01547198_g1 NM_016533 NINJ2 Hs00356576_m1 NM_033120 NKD2 Hs00263909_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_000435 NOTCH3 Hs01128541_m1 NM_016931 NOX4 Hs01558199_m1 NM_003995 NPR2 Hs00241516_m1 NM_016588 NRN1 Hs00213192_m1 AF145712 NRP1 Hs00826121_m1 NM_001024628 NRP1 Hs00826121_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_002526 NT5E Hs01573922_m1 NM_016522 NTM Hs00275411_m1 NM_016522 NTM Hs00275411_m1 NM_014840 NUAK1 Hs00934234_m1 NM_019094 NUDT4 Hs00819603_m1 NM_178507 OAF Hs00420156_m1 144 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_015441 OLFML2B Hs00827139_g1 NM_020190 OLFML3 Hs00220180_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_003999 OSMR Hs00187782_m1 NM_182904 P4HA3 Hs00420085_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_000919 PAM Hs00168596_m1 NM_000919 PAM Hs00168596_m1 AF237771 PARVA Hs00217177_m1 NM_018222 PARVA Hs00217177_m1 NM_019035 PCDH18 Hs00251855_m1 NM_019035 PCDH18 Hs00251855_m1 AB006757 PCDH7 Hs00361092_m1 NM_002589 PCDH7 Hs00159908_m1 AF152318 PCDHGA1 Hs00251717_m1 NM_002588 PCDHGC3 Hs00251717_m1 BC006439 PCDHGC3 Hs00251717_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_016205 PDGFC Hs00211916_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 NM_021630 PDLIM2 Hs00222154_m1 NM_005451 PDLIM7 Hs01103929_g1 NM_005451 PDLIM7 Hs01103929_g1 NM_005451 PDLIM7 Hs01103929_g1 NM_001006624 PDPN Hs01089982_g1 NM_001006624 PDPN Hs01089982_g1 NM_006474 PDPN Hs01089982_g1 NM_015009 PDZRN3 Hs00392900_m1 NM_015157 PHLDB1 Hs00384827_m1 NM_000297 PKD2 Hs00165517_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_002658 PLAU Hs00170182_m1 K03226 PLAU Hs00170182_m1 145 AY029180 PLAUR Hs00959822_m1 NM_173542 PLBD2 Hs00381310_m1 NM_000445 PLEC Hs00356977_m1 NM_005032 PLS3 Hs00192406_m1 NM_020353 PLSCR4 Hs00924823_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_032812 PLXDC2 Hs00262350_m1 NM_005761 PLXNC1 Hs00955621_m1 NM_020182 PMEPA1 Hs03987603_g1 NM_020182 PMEPA1 Hs03987603_g1 L03203 PMP22 Hs00165556_m1 NM_153703 PODN Hs00542259_m1 D13665 POSTN Hs01566750_m1 NM_001030059 PPAPDC1A Hs00404185_m1 BC006362 PPAPDC3 Hs00262043_m1 NM_000943 PPIC Hs00181460_m1 NM_000943 PPIC Hs00181460_m1 NM_012231 PRDM2 Hs00202013_m1 AF272898 PRDM6 Hs01373000_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_145040 PRKCDBP Hs00293638_m1 NM_002742 PRKD1 Hs00177037_m1 NM_024841 PRR5L Hs00757785_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_016307 PRRX2 Hs00212537_m1 NM_020440 PTGFRN Hs01385989_m1 NM_002821 PTK7 Hs00897151_m1 NM_007039 PTPN21 Hs00234784_m1 NM_002839 PTPRD Hs00295441_s1 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 AF183421 RAB31 Hs00199313_m1 NM_006868 RAB31 Hs00199313_m1 NM_006868 RAB31 Hs00199313_m1 NM_015577 RAI14 Hs00210238_m1 BC000069 RARRES2 Hs00161209_g1 NM_007368 RASA3 Hs00183698_m1 NM_006909 RASGRF2 Hs00394798_m1 D28482 RBMS1 Hs00249930_s1 NM_014483 RBMS3 Hs00205567_m1 NM_005822 RCAN2 Hs00195165_m1 NM_020650 RCN3 Hs00276633_m1 146 NM_020650 RCN3 Hs00276633_m1 NM_021111 RECK Hs01019179_m1 NM_017821 RHBDL2 Hs00384848_m1 NM_020663 RHOJ Hs00368156_m1 AL136924 RIN2 Hs00610937_m1 NM_014746 RNF144A Hs00207267_m1 NM_005012 ROR1 Hs00178178_m1 NM_004560 ROR2 Hs00896176_m1 NM_001006932 RPS6KA2 Hs00179731_m1 D43968 RUNX1 Hs00231079_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001015051 RUNX2 Hs00298328_s1 NM_001015051 RUNX2 Hs00298328_s1 NM_002968 SALL1 Hs00231307_m1 NM_153334 SCARF2 Hs00544847_m1 NM_001006946 SDC1 Hs00896425_g1 NM_006364 SEC23A Hs00197232_m1 NM_014933 SEC31A Hs00274601_m1 NM_003966 SEMA5A Hs01549381_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 AF311912 SFRP2 Hs00293258_m1 NM_003013 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 U58331 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_001009555 SH3D19 Hs00296942_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_001017995 SH3PXD2B Hs00375183_s1 NM_006884 SHOX2 Hs01059691_m1 AF022654 SHOX2 Hs00243203_m1 NM_033518 SLC38A5 Hs01012028_m1 NM_152264 SLC39A13 Hs00378317_m1 NM_004787 SLIT2 Hs00191193_m1 147 AF055585 SLIT2 Hs00191193_m1 AB011538 SLIT3 Hs00171524_m1 NM_003062 SLIT3 Hs00171524_m1 NM_005904 SMAD7 Hs00998193_m1 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 NM_006932 SMTN Hs00199489_m1 AF064238 SMTN Hs00199489_m1 NM_003068 SNAI2 Hs00950344_m1 NM_018013 SOBP Hs00215979_m1 NM_020777 SORCS2 Hs00325181_m1 NM_003118 SPARC Hs00277762_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_015535 SPATS2L Hs00274702_m1 NM_021972 SPHK1 Hs00184211_m1 AF231124 SPOCK1 Hs00270274_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 AB051390 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_025106 SPSB1 Hs00228304_m1 NM_025106 SPSB1 Hs00228304_m1 U83867 SPTAN1 Hs00162203_m1 NM_006307 SRPX Hs00196867_m1 NM_014467 SRPX2 Hs00997580_m1 NM_018984 SSH1 Hs00368014_m1 AL136756 SSPN Hs00296706_s1 NM_005086 SSPN Hs00296706_s1 NM_006927 ST3GAL2 Hs00199480_m1 NM_005418 ST5 Hs00936461_m1 NM_032528 ST6GAL2 Hs00290088_s1 NM_015170 SULF1 Hs00290918_m1 NM_015170 SULF1 Hs00290918_m1 NM_018837 SULF2 Hs00378697_m1 NM_018837 SULF2 Hs00378697_m1 NM_033025 SYDE1 Hs00263581_m1 NM_024893 SYNDIG1 Hs00227616_m1 NM_007286 SYNPO Hs00702468_s1 NM_080737 SYTL4 Hs00299039_m1 NM_003186 TAGLN Hs00162558_m1 AF234997 TAX1BP3 Hs00205924_m1 NM_014604 TAX1BP3 Hs00205924_m1 NM_015079 TBC1D2B Hs00534954_m1 148 NM_152380 TBX15 Hs00537087_m1 NM_000192 TBX5 Hs00361155_m1 NM_152278 TCEAL7 Hs00385936_m1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 BC000125 TGFB1 Hs00998133_m1 BC001830 TGFB1I1 Hs00210887_m1 J03241 TGFB3 Hs01086000_m1 NM_000358 TGFBI Hs03987596_s1 NM_003247 THBS2 Hs01568063_m1 NM_006288 THY1 Hs00264235_s1 NM_006288 THY1 Hs00264235_s1 AL161958 THY1 Hs00264235_s1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 NM_000362 TIMP3 Hs00927216_m1 U67195 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_006289 TLN1 Hs00971189_g1 NM_024600 TMEM204 Hs01061927_m1 NM_024334 TMEM43 Hs00225702_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_018647 TNFRSF19 Hs00218634_m1 NM_001065 TNFRSF1A Hs00533568_g1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_003289 TPM2 Hs00268540_m1 NM_003290 TPM4 Hs01861627_g1 NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_024164 TPSB2 Hs02576518_gH NM_003596 TPST1 Hs00234324_m1 NM_012288 TRAM2 Hs00202213_m1 NM_003304 TRPC1 Hs00608195_m1 AL136805 TSHZ3 Hs02379784_s1 NM_020856 TSHZ3 Hs02379784_s1 149 AF054841 TSPAN4 Hs01587032_m1 BC002654 TUBB6 Hs00603164_m1 NM_000474 TWIST1 Hs00361186_m1 NM_057179 TWIST2 Hs00382379_m1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 NM_014909 VASH1 Hs00208609_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 D32039 VCAN Hs01007941_m1 NM_004385 VCAN Hs01007944_m1 NM_014000 VCL Hs00243320_m1 NM_016206 VGLL3 Hs00275109_s1 NM_003380 VIM Hs00958116_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_152348 WDR81 Hs00400556_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003881 WISP2 Hs00180242_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_015472 WWTR1 Hs00210007_m1 NM_145166 ZBTB47 Hs00908860_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_030751 ZEB1 Hs01566407_m1 U12170 ZEB1 Hs01566407_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_024721 ZFHX4 Hs00257312_s1 NM_006887 ZFP36L2 Hs00272828_m1 NM_006887 ZFP36L2 Hs00272828_m1 NM_012082 ZFPM2 Hs00201397_m1 NM_022470 ZMAT3 Hs00223860_m1 NM_015069 ZNF423 Hs00323880_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 NM_001010972 ZYX Hs00170299_m1 NM_003461 ZYX Hs00170299_m1 150 COL6A2 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_007168 ABCA8 Hs00992371_m1 NM_005157 ABL1 Hs01104721_m1 NM_001033583 ACOT9 Hs00202482_m1 NM_001613 ACTA2 Hs00426835_g1 M95178 ACTN1 Hs00998100_m1 BC003576 ACTN1 Hs00998100_m1 NM_001102 ACTN1 Hs00998100_m1 NM_001105 ACVR1 Hs00153836_m1 NM_000020 ACVRL1 Hs00163543_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_025220 ADAM33 Hs00296426_m1 NM_139056 ADAMTS16 Hs01049997_m1 NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_197941 ADAMTS6 Hs00812159_s1 NM_052998 ADC Hs00364871_m1 AF284095 ADRA2A Hs00265081_s1 NM_001129 AEBP1 Hs00937468_m1 NM_006796 AFG3L2 Hs00255224_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 M90360 AKAP13 Hs00407844_m1 NM_006738 AKAP13 Hs00331658_s1 NM_005465 AKT3 Hs00289302_s1 NM_001034173 ALDH1L2 Hs00402876_m1 NM_130847 AMOTL1 Hs00294070_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_001148 ANK2 Hs00153998_m1 NM_054027 ANKH Hs00219798_m1 NM_054027 ANKH Hs00219798_m1 151 NM_014942 ANKRD6 Hs00208902_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_000700 ANXA1 Hs00945401_m1 NM_003734 AOC3 Hs00186647_m1 NM_153000 APCDD1 Hs00537787_m1 NM_015242 ARAP1 Hs00362929_m1 NM_004308 ARHGAP1 Hs00188815_m1 NM_020809 ARHGAP20 Hs00826991_m1 NM_001025616 ARHGAP24 Hs01097580_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_020754 ARHGAP31 Hs00393361_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_005737 ARL4C Hs00255039_s1 NM_000047 ARSE Hs01033722_m1 AF316824 ASPN Hs00214395_m1 NM_017680 ASPN Hs00214395_m1 NM_001007026 ATN1 Hs00157312_m1 NM_001003696 ATP5J Hs01081389_g1 NM_000332 ATXN1 Hs00165656_m1 NM_001699 AXL Hs01064444_m1 NM_021913 AXL Hs01064444_m1 NM_033309 B3GNT9 Hs00740919_g1 NM_012104 BACE1 Hs01123242_m1 NM_021813 BACH2 Hs00222364_m1 NM_181844 BCL6B Hs00394655_m1 NM_152731 BEND6 Hs00288163_m1 NM_001711 BGN Hs00959143_m1 BC002416 BGN Hs00959143_m1 NM_001711 BGN Hs00959143_m1 NM_152414 BHLHE22 Hs01084964_s1 NM_017614 BHMT2 Hs00214120_m1 NM_017614 BHMT2 Hs00214120_m1 NM_006129 BMP1 Hs00196183_m1 NM_001199 BMP1 Hs00986789_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 AY027658 BOC Hs00264408_m1 152 NM_033254 BOC Hs00264408_m1 AL136653 C10orf10 Hs00199735_m1 NM_014059 C13orf15 Hs00204129_m1 NM_032849 C13orf33 Hs00262558_m1 NM_030968 C1QTNF1 Hs00945123_m1 NM_030945 C1QTNF3 Hs00229569_m1 AF329841 C1QTNF5 Hs00363053_g1 NM_031910 C1QTNF6 Hs00230464_m1 AF329842 C1QTNF6 Hs00230464_m1 NM_031911 C1QTNF7 Hs00230467_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 NM_000064 C3 Hs00163811_m1 NM_004772 C5orf13 Hs00854282_g1 AF313413 C5orf62 Hs00383944_m1 NM_183373 C6orf145 Hs00406043_m1 NM_001013842 C8orf58 Hs00543616_m1 NM_000722 CACNA2D1 Hs00984856_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 BC000039 CALHM2 Hs00374996_m1 NM_015916 CALHM2 Hs00374996_m1 NM_004930 CAPZB Hs00191827_m1 AF356193 CARD6 Hs01123611_m1 NM_001753 CAV1 Hs00971716_m1 NM_001753 CAV1 Hs00971716_m1 NM_001233 CAV2 Hs00184597_m1 NM_001233 CAV2 Hs00184597_m1 AL136562 CCDC3 Hs00230222_m1 AL136609 CCDC8 Hs00540204_s1 NM_032040 CCDC8 Hs00540204_s1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_025140 CCDC92 Hs00228468_m1 NM_001759 CCND2 Hs00922419_g1 NM_020404 CD248 Hs00535586_s1 NM_001024736 CD276 Hs00987207_m1 M81104 CD34 Hs00990735_m1 NM_012072 CD93 Hs00362607_m1 NM_002414 CD99 Hs00365982_m1 U82164 CD99 Hs00242853_m1 153 NM_002414 CD99 Hs00365982_m1 NM_145057 CDC42EP5 Hs01936746_s1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_001795 CDH5 Hs00901463_m1 NM_004936 CDKN2B Hs00793225_m1 NM_016174 CERCAM Hs00170969_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_000204 CFI Hs00989715_m1 NM_003956 CH25H Hs02379634_s1 NM_018413 CHST11 Hs00218229_m1 NM_130468 CHST14 Hs00944245_s1 AB017915 CHST3 Hs01000045_m1 NM_175856 CHSY3 Hs00545664_m1 NM_003613 CILP Hs00173647_m1 D86586 CLEC11A Hs00161544_m1 NM_002975 CLEC11A Hs00161544_m1 BC005810 CLEC11A Hs00161544_m1 NM_175060 CLEC14A Hs00545534_s1 BC005254 CLEC2B Hs00192860_m1 NM_015526 CLIP3 Hs00367493_m1 NM_024769 CLMP Hs00956750_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 NM_001299 CNN1 Hs00154543_m1 NM_004368 CNN2 Hs00854264_s1 NM_015463 CNRIP1 Hs00384403_m1 NM_000493 COL10A1 Hs00166657_m1 NM_000493 COL10A1 Hs00166657_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 NM_001856 COL16A1 Hs00156876_m1 AF018081 COL18A1 Hs01043425_g1 NM_030582 COL18A1 Hs01043425_g1 NM_000088 COL1A1 Hs01076775_g1 154 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_001846 COL4A2 Hs01098873_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 NM_000393 COL5A2 Hs00893923_m1 NM_015719 COL5A3 Hs00210526_m1 NM_015719 COL5A3 Hs00210526_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 AY029208 COL6A2 Hs00242484_m1 NM_004369 COL6A3 Hs00915120_m1 NM_001850 COL8A1 Hs00156669_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_000095 COMP Hs00164359_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_001864 COX7A1 Hs00156989_m1 NM_019609 CPXM1 Hs01566704_g1 NM_198148 CPXM2 Hs00406866_m1 BC006393 CPZ Hs00186333_m1 AL136861 CRISPLD2 Hs00230322_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_138455 CTHRC1 Hs00298917_m1 NM_014772 CTIF Hs00207460_m1 NM_000396 CTSK Hs00166156_m1 NM_000609 CXCL12 Hs00930455_m1 NM_020311 CXCR7 Hs00664172_s1 NM_000398 CYB5R3 Hs00240921_m1 NM_134268 CYGB Hs00370478_m1 AF003114 CYR61 Hs00998503_g1 155 NM_001554 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 NM_015345 DAAM2 Hs00322497_m1 BC003064 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_003737 DCHS1 Hs01044548_m1 NM_001920 DCN Hs00754870_s1 AF138303 DCN Hs00266491_m1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_001920 DCN Hs00754870_s1 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_006182 DDR2 Hs01025953_m1 NM_013989 DIO2 Hs00255341_m1 NM_014974 DIP2C Hs00324224_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 NM_006094 DLC1 Hs00183436_m1 AF026219 DLC1 Hs00931487_m1 NM_001005336 DNM1 Hs00189369_m1 M80536 DPP4 Hs00175210_m1 M74777 DPP4 Hs00175210_m1 NM_001935 DPP4 Hs00175210_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001386 DPYSL2 Hs00954558_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_013352 DSE Hs00203441_m1 NM_014934 DZIP1 Hs00208790_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_001393 ECM2 Hs00154821_m1 NM_005711 EDIL3 Hs00174781_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_016938 EFEMP2 Hs00213545_m1 156 AB030655 EFEMP2 Hs00213545_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_005230 ELK3 Hs00987814_m1 NM_000501 ELN Hs01091772_m1 NM_000501 ELN Hs01091772_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_001425 EMP3 Hs00171319_m1 NM_004098 EMX2 Hs00244574_m1 NM_000118 ENG Hs03986114_s1 NM_001776 ENTPD1 Hs00739960_s1 NM_001430 EPAS1 Hs01026142_m1 NM_001431 EPB41L2 Hs00154988_m1 NM_004449 ERG Hs01554635_m1 NM_138961 ESAM Hs00332781_m1 NM_004956 ETV1 Hs00290469_s1 NM_147127 EVC2 Hs00377633_m1 NM_000129 F13A1 Hs00173388_m1 NM_001992 F2R Hs00169258_m1 NM_004101 F2RL2 Hs00187982_m1 NM_182705 FAM101B Hs00823804_m1 NM_182705 FAM101B Hs00823804_m1 NM_020223 FAM20C Hs00398243_m1 NM_153711 FAM26E Hs00382139_m1 NM_024519 FAM65A Hs00225927_m1 U76833 FAP Hs00990806_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_006832 FERMT2 Hs01041255_m1 NM_006832 FERMT2 Hs01041255_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 BC006245 FGF18 Hs00818572_m1 NM_003862 FGF18 Hs00818572_m1 NM_003862 FGF18 Hs00818572_m1 AF098518 FHL1 Hs00793641_g1 157 NM_001449 FHL1 Hs00793641_g1 AF063002 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 NM_004468 FHL3 Hs00189516_m1 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 NM_014890 FILIP1L Hs00706279_s1 NM_017946 FKBP14 Hs00942521_m1 AF100751 FKBP7 Hs00535040_m1 NM_007270 FKBP9 Hs00414859_m1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_001458 FLNC Hs00155124_m1 AF169676 FLRT2 Hs00544171_s1 NM_013231 FLRT2 Hs00544171_s1 NM_175736 FMNL3 Hs00604672_m1 NM_002021 FMO1 Hs00266654_m1 BC005858 FN1 Hs00415006_m1 AF130095 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_032532 FNDC1 Hs00287359_m1 NM_005253 FOSL2 Hs00232013_m1 NM_005253 FOSL2 Hs00232013_m1 NM_005253 FOSL2 Hs00232013_m1 NM_001452 FOXF2 Hs00230963_m1 NM_005197 FOXN3 Hs00830558_g1 NM_005197 FOXN3 Hs00830558_g1 NM_002015 FOXO1 Hs00231106_m1 NM_002015 FOXO1 Hs00231106_m1 NM_152330 FRMD6 Hs00378563_m1 NM_152330 FRMD6 Hs00378563_m1 NM_003088 FSCN1 Hs00979631_g1 NM_013409 FST Hs00246256_m1 NM_006350 FST Hs00246260_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_000148 FUT1 Hs00355741_m1 NM_005031 FXYD1 Hs00245327_m1 M14333 FYN Hs00941600_m1 NM_003505 FZD1 Hs00268943_s1 AF078077 GADD45B Hs00169587_m1 AF087853 GADD45B Hs00169587_m1 158 NM_015675 GADD45B Hs00169587_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 NM_002048 GAS1 Hs00266715_s1 L13720 GAS6 Hs01090305_m1 NM_000820 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 NM_003644 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005261 GEM Hs00738924_m1 NM_005110 GFPT2 Hs01049561_m1 NM_004121 GGT5 Hs00269779_m1 NM_005266 GJA5 Hs00270952_s1 M86849 GJB2 Hs00269615_s1 NM_012201 GLG1 Hs00953976_s1 NM_005270 GLI2 Hs00257977_m1 NM_032575 GLIS2 Hs00402743_g1 NM_152629 GLIS3 Hs00295084_s1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_004126 GNG11 Hs00914578_m1 NM_053064 GNG2 Hs00828232_m1 NM_005708 GPC6 Hs00170677_m1 NM_002510 GPNMB Hs01095679_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_207370 GPR153 Hs01112674_m1 NM_007223 GPR176 Hs01064696_m1 NM_015696 GPX7 Hs00210410_m1 NM_001008397 GPX8 Hs00380670_m1 AF154054 GREM1 Hs00171951_m1 NM_013372 GREM1 Hs00171951_m1 NM_002091 GRP Hs00181852_m1 NM_000177 GSN Hs00388617_m1 NM_016315 GULP1 Hs00169604_m1 AF200715 GULP1 Hs00169604_m1 NR_002196 H19 Hs00262142_g1 NR_002196 H19 Hs00262142_g1 NM_014799 HEPH Hs00953259_m1 NM_014571 HEYL Hs01113778_m1 NM_031935 HMCN1 Hs00399043_m1 NM_016245 HSD17B11 Hs00212226_m1 159 NM_052970 HSPA12B Hs00369554_m1 NM_052970 HSPA12B Hs00369554_m1 NM_001541 HSPB2 Hs00155436_m1 NM_005529 HSPG2 Hs01078536_m1 M85289 HSPG2 Hs01078536_m1 NM_002775 HTRA1 Hs01016151_m1 NM_053044 HTRA3 Hs01099710_m1 NM_053044 HTRA3 Hs01099710_m1 NM_002167 ID3 Hs00171409_m1 BC002857 IFFO1 Hs00209967_m1 NM_020962 IGDCC4 Hs00326335_m1 NM_000618 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 M17863 IGF2 Hs03929076_gH NM_000612 IGF2 Hs00277496_s1 NM_001007139 IGF2 Hs00277496_s1 NM_000598 IGFBP3 Hs00426289_m1 M31159 IGFBP3 Hs00181211_m1 NM_001552 IGFBP4 Hs00181767_m1 NM_002178 IGFBP6 Hs00942697_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_138284 IL17D Hs00370528_m1 NM_000877 IL1R1 Hs00991002_m1 NM_004517 ILK Hs00177914_m1 NM_002192 INHBA Hs01081598_m1 M13436 INHBA Hs01081598_m1 NM_005545 ISLR Hs01921558_s1 AF109681 ITGA11 Hs01012939_m1 NM_002205 ITGA5 Hs01547673_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_030569 ITIH5 Hs00262393_s1 NM_033397 ITPRIP Hs01878396_s1 AF114488 ITSN1 Hs00161676_m1 NM_001001132 ITSN1 Hs00161676_m1 AF114488 ITSN1 Hs00161676_m1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_130469 JDP2 Hs00185689_m1 NM_015493 KANK2 Hs00795260_m1 NM_181712 KANK4 Hs00400916_m1 160 AF160967 KCNMB4 Hs00205704_m1 NM_138444 KCTD12 Hs00540818_s1 NM_024089 KDELC1 Hs00607574_g1 NM_007035 KERA Hs00559942_m1 NM_001009880 KIAA0930 Hs00292272_m1 NM_019590 KIAA1217 Hs00289569_m1 NM_018012 KIF26B Hs00215977_m1 NM_018240 KIRREL Hs00217307_m1 NM_005655 KLF10 Hs00921811_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002290 LAMA4 Hs00935293_m1 M20206 LAMB1 Hs01055971_m1 NM_002291 LAMB1 Hs01055971_m1 NM_002293 LAMC1 Hs00267056_m1 AF207547 LATS2 Hs00324396_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_001290 LDB2 Hs00609711_m1 NM_022356 LEPRE1 Hs00223565_m1 NM_014262 LEPREL2 Hs00204607_m1 NM_002305 LGALS1 Hs00355202_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_199000 LHFPL3 Hs01585188_s1 NM_016357 LIMA1 Hs00212557_m1 NM_017980 LIMS2 Hs01002880_gH NM_153713 LIX1L Hs00542269_m1 NM_014583 LMCD1 Hs00205871_m1 NM_005572 LMNA Hs01108898_g1 NM_012134 LMOD1 Hs00201704_m1 NM_002317 LOX Hs00942480_m1 NM_002317 LOX Hs00942480_m1 NM_005576 LOXL1 Hs00935937_m1 NM_002318 LOXL2 Hs00158757_m1 NM_001401 LPAR1 Hs00173500_m1 NM_001401 LPAR1 Hs00173500_m1 NM_015116 LRCH1 Hs00996581_m1 NM_020871 LRCH2 Hs00325819_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_130830 LRRC15 Hs00370056_s1 NM_005824 LRRC17 Hs00180581_m1 NM_005512 LRRC32 Hs00194136_m1 161 NM_002339 LSP1 Hs00158886_m1 AF113211 LTBP2 Hs00544640_s1 NM_000428 LTBP2 Hs00544640_s1 NM_002345 LUM Hs00158940_m1 NM_002345 LUM Hs00158940_m1 NM_033631 LUZP1 Hs00612276_m1 NM_033631 LUZP1 Hs00612276_m1 NM_021020 LZTS1 Hs00232762_m1 NM_005461 MAFB Hs00271378_s1 NM_005461 MAFB Hs00271378_s1 NM_019066 MAGEL2 Hs00255922_s1 NM_002373 MAP1A Hs00357973_m1 NM_002375 MAP4 Hs00159048_m1 NM_002375 MAP4 Hs00159048_m1 NM_002375 MAP4 Hs00159048_m1 NM_002375 MAP4 Hs00159048_m1 M64571 MAP4 Hs00159048_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_004834 MAP4K4 Hs00377415_m1 BC004995 MARVELD1 Hs00230362_m1 NM_017459 MFAP2 Hs01027737_m1 NM_002404 MFAP4 Hs00412974_m1 U37283 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_002406 MGAT1 Hs01855897_s1 NM_014632 MICAL2 Hs01121806_m1 NM_014632 MICAL2 Hs01121806_m1 NM_000248 MITF Hs01117294_m1 NM_000248 MITF Hs01117294_m1 NM_005940 MMP11 Hs00171829_m1 NM_005940 MMP11 Hs00171829_m1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 AL136588 MMP16 Hs00540314_s1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 NM_002430 MN1 Hs00159202_m1 NM_023075 MPPE1 Hs00372745_g1 NM_015134 MPRIP Hs00819388_m1 NM_015134 MPRIP Hs00819388_m1 NM_006039 MRC2 Hs00195862_m1 162 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 AF060154 MSC Hs00231955_m1 NM_002444 MSN Hs01085677_g1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 AF245505 MXRA5 Hs00295630_s1 NM_001008528 MXRA7 Hs00895155_m1 NM_001008528 MXRA7 Hs00895155_m1 NM_032348 MXRA8 Hs00260584_m1 NM_002473 MYH9 Hs00159522_m1 NM_006097 MYL9 Hs00697086_m1 NM_015194 MYO1D Hs00381456_m1 NM_004998 MYO1E Hs00192232_m1 NM_005468 NAALADL1 Hs00193839_m1 NM_052867 NALCN Hs00291166_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_005380 NBL1 Hs00185054_m1 NM_005380 NBL1 Hs00185054_m1 U35139 NDN Hs00267349_s1 NM_173808 NEGR1 Hs01584331_m1 NM_144573 NEXN Hs00332124_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_007361 NID2 Hs01547198_g1 NM_016533 NINJ2 Hs00356576_m1 NM_033120 NKD2 Hs00263909_m1 NM_001189 NKX3-2 Hs00154168_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_000435 NOTCH3 Hs01128541_m1 NM_002514 NOV Hs00159631_m1 NM_002514 NOV Hs00159631_m1 NM_016931 NOX4 Hs01558199_m1 NM_003995 NPR2 Hs00241516_m1 NM_016588 NRN1 Hs00213192_m1 AF145712 NRP1 Hs00826121_m1 NM_001024628 NRP1 Hs00826121_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_002526 NT5E Hs01573922_m1 NM_002526 NT5E Hs01573922_m1 163 NM_016522 NTM Hs00275411_m1 NM_016522 NTM Hs00275411_m1 NM_014840 NUAK1 Hs00934234_m1 NM_019094 NUDT4 Hs00819603_m1 NM_178507 OAF Hs00420156_m1 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_015441 OLFML2B Hs00827139_g1 NM_020190 OLFML3 Hs00220180_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_003999 OSMR Hs00187782_m1 NM_182904 P4HA3 Hs00420085_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_002579 PALM Hs00608156_m1 NM_000919 PAM Hs00168596_m1 AF237771 PARVA Hs00217177_m1 NM_018222 PARVA Hs00217177_m1 NM_019035 PCDH18 Hs00251855_m1 NM_019035 PCDH18 Hs00251855_m1 AB006757 PCDH7 Hs00361092_m1 NM_002589 PCDH7 Hs00159908_m1 AF152318 PCDHGA1 Hs00251717_m1 NM_002588 PCDHGC3 Hs00251717_m1 BC006439 PCDHGC3 Hs00251717_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_004716 PCSK7 Hs00237114_m1 NM_000921 PDE3A Hs01012698_m1 NM_016205 PDGFC Hs00211916_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 NM_021630 PDLIM2 Hs00222154_m1 NM_005451 PDLIM7 Hs01103929_g1 NM_005451 PDLIM7 Hs01103929_g1 NM_005451 PDLIM7 Hs01103929_g1 NM_001006624 PDPN Hs01089982_g1 NM_006474 PDPN Hs01089982_g1 NM_001006624 PDPN Hs01089982_g1 164 NM_015009 PDZRN3 Hs00392900_m1 NM_015157 PHLDB1 Hs00384827_m1 NM_017933 PID1 Hs00952182_m1 NM_000297 PKD2 Hs00165517_m1 NM_000929 PLA2G5 Hs00173472_m1 NM_001007267 PLA2R1 Hs00234853_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_006718 PLAGL1 Hs00414677_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_002656 PLAGL1 Hs00243030_m1 K03226 PLAU Hs00170182_m1 NM_002658 PLAU Hs00170182_m1 U08839 PLAUR Hs00182181_m1 AY029180 PLAUR Hs00959822_m1 NM_173542 PLBD2 Hs00381310_m1 NM_002667 PLN Hs00160179_m1 NM_005032 PLS3 Hs00192406_m1 NM_020360 PLSCR3 Hs00220521_m1 NM_020360 PLSCR3 Hs00220521_m1 NM_020353 PLSCR4 Hs00924823_m1 NM_006227 PLTP Hs00272126_m1 AF326591 PLVAP Hs00229941_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_032812 PLXDC2 Hs00262350_m1 NM_005761 PLXNC1 Hs00955621_m1 NM_020182 PMEPA1 Hs03987603_g1 NM_020182 PMEPA1 Hs03987603_g1 NM_020182 PMEPA1 Hs03987603_g1 L03203 PMP22 Hs00165556_m1 NM_153703 PODN Hs00542259_m1 D13665 POSTN Hs01566750_m1 AF014403 PPAP2A Hs00170356_m1 AB000888 PPAP2A Hs00170356_m1 NM_003713 PPAP2B Hs00170359_m1 NM_001030059 PPAPDC1A Hs00404185_m1 BC006362 PPAPDC3 Hs00262043_m1 NM_000943 PPIC Hs00181460_m1 NM_000943 PPIC Hs00181460_m1 NM_012231 PRDM2 Hs00202013_m1 AF272898 PRDM6 Hs01373000_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_153026 PRICKLE1 Hs01055551_m1 165 NM_153026 PRICKLE1 Hs01055551_m1 NM_198859 PRICKLE2 Hs00291033_s1 NM_145040 PRKCDBP Hs00293638_m1 NM_002742 PRKD1 Hs00177037_m1 NM_000313 PROS1 Hs00165590_m1 NM_001017528 PRR5 Hs00214502_m1 NM_024841 PRR5L Hs00757785_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_016307 PRRX2 Hs00212537_m1 NM_020440 PTGFRN Hs01385989_m1 NM_000961 PTGIS Hs00919949_m1 NM_002821 PTK7 Hs00897151_m1 NM_007039 PTPN21 Hs00234784_m1 NM_002839 PTPRD Hs00295441_s1 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 NM_006775 QKI Hs00287641_m1 NM_006868 RAB31 Hs00199313_m1 AF183421 RAB31 Hs00199313_m1 NM_006868 RAB31 Hs00199313_m1 NM_177403 RAB7B Hs00536338_s1 NM_015577 RAI14 Hs00210238_m1 BC000069 RARRES2 Hs00161209_g1 NM_007368 RASA3 Hs00183698_m1 NM_006909 RASGRF2 Hs00394798_m1 D28482 RBMS1 Hs00249930_s1 NM_014483 RBMS3 Hs00205567_m1 NM_005822 RCAN2 Hs00195165_m1 NM_001268 RCBTB2 Hs00154390_m1 NM_020650 RCN3 Hs00276633_m1 NM_020650 RCN3 Hs00276633_m1 NM_021111 RECK Hs01019179_m1 NM_144629 RFTN2 Hs00376096_m1 NM_017821 RHBDL2 Hs00384848_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 AL136924 RIN2 Hs00610937_m1 NM_014746 RNF144A Hs00207267_m1 NM_019055 ROBO4 Hs00219408_m1 NM_005012 ROR1 Hs00178178_m1 NM_004560 ROR2 Hs00896176_m1 BC002363 RPS6KA2 Hs00179731_m1 166 NM_001006932 RPS6KA2 Hs00179731_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001015051 RUNX2 Hs00298328_s1 NM_001015051 RUNX2 Hs00298328_s1 NM_002961 S100A4 Hs00243202_m1 NM_153334 SCARF2 Hs00544847_m1 NM_001006946 SDC1 Hs00896425_g1 NM_006364 SEC23A Hs00197232_m1 NM_014933 SEC31A Hs00274601_m1 NM_003966 SEMA5A Hs01549381_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_006216 SERPINE2 Hs00385730_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 AF311912 SFRP2 Hs00293258_m1 NM_003013 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 U58331 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 AL136561 SGIP1 Hs00260297_m1 NM_001009555 SH3D19 Hs00296942_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_001017995 SH3PXD2B Hs00375183_s1 NM_006884 SHOX2 Hs01059691_m1 AF022654 SHOX2 Hs00243203_m1 NM_078483 SLC36A1 Hs01092773_m1 NM_033518 SLC38A5 Hs01012028_m1 NM_152264 SLC39A13 Hs00378317_m1 NM_152270 SLFN11 Hs00536981_m1 NM_004787 SLIT2 Hs00191193_m1 AF055585 SLIT2 Hs00191193_m1 AB011538 SLIT3 Hs00171524_m1 NM_003062 SLIT3 Hs00171524_m1 NM_005904 SMAD7 Hs00998193_m1 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 167 NM_006932 SMTN Hs00199489_m1 AF064238 SMTN Hs00199489_m1 NM_003068 SNAI2 Hs00950344_m1 NM_018013 SOBP Hs00215979_m1 NM_020777 SORCS2 Hs00325181_m1 NM_003118 SPARC Hs00277762_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_015535 SPATS2L Hs00274702_m1 NM_021972 SPHK1 Hs00184211_m1 AF231124 SPOCK1 Hs00270274_m1 AB051390 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_005841 SPRY1 Hs01083036_s1 NM_025106 SPSB1 Hs00228304_m1 NM_025106 SPSB1 Hs00228304_m1 NM_006307 SRPX Hs00196867_m1 NM_014467 SRPX2 Hs00997580_m1 NM_018984 SSH1 Hs00368014_m1 AL136756 SSPN Hs00296706_s1 NM_005086 SSPN Hs00296706_s1 NM_006927 ST3GAL2 Hs00199480_m1 NM_005418 ST5 Hs00936461_m1 NM_032528 ST6GAL2 Hs00290088_s1 NM_015170 SULF1 Hs00290918_m1 NM_018837 SULF2 Hs00378697_m1 NM_018837 SULF2 Hs00378697_m1 NM_033025 SYDE1 Hs00263581_m1 NM_033025 SYDE1 Hs00263581_m1 NM_024893 SYNDIG1 Hs00227616_m1 NM_007286 SYNPO Hs00702468_s1 NM_080737 SYTL4 Hs00299039_m1 NM_006283 TACC1 Hs00180691_m1 NM_003186 TAGLN Hs00162558_m1 NM_014604 TAX1BP3 Hs00205924_m1 AF234997 TAX1BP3 Hs00205924_m1 NM_015079 TBC1D2B Hs00534954_m1 NM_152380 TBX15 Hs00537087_m1 NM_000192 TBX5 Hs00361155_m1 NM_152278 TCEAL7 Hs00385936_m1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 168 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 BC000125 TGFB1 Hs00998133_m1 BC001830 TGFB1I1 Hs00210887_m1 J03241 TGFB3 Hs01086000_m1 NM_000358 TGFBI Hs03987596_s1 NM_003247 THBS2 Hs01568063_m1 NM_003248 THBS4 Hs00170261_m1 NM_006288 THY1 Hs00264235_s1 NM_006288 THY1 Hs00264235_s1 AL161958 THY1 Hs00264235_s1 NM_005424 TIE1 Hs00892696_m1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 U67195 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_004614 TK2 Hs00936918_m1 NM_006289 TLN1 Hs00971189_g1 AB002318 TLN2 Hs00322257_m1 NM_024600 TMEM204 Hs01061927_m1 NM_024334 TMEM43 Hs00225702_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_001065 TNFRSF1A Hs00533568_g1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_022748 TNS3 Hs00224228_m1 BC000474 TP53I3 Hs00153280_m1 NM_003289 TPM2 Hs00268540_m1 NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_024164 TPSB2 Hs02576518_gH NM_003596 TPST1 Hs00234324_m1 NM_012288 TRAM2 Hs00202213_m1 NM_003304 TRPC1 Hs00608195_m1 NM_003304 TRPC1 Hs00608195_m1 NM_020856 TSHZ3 Hs02379784_s1 169 AL136805 TSHZ3 Hs02379784_s1 NM_005725 TSPAN2 Hs00194836_m1 AF054841 TSPAN4 Hs01587032_m1 BC000389 TSPAN4 Hs01587032_m1 AB028966 TTC28 Hs01117728_m1 BC002654 TUBB6 Hs00603164_m1 NM_000474 TWIST1 Hs00361186_m1 NM_057179 TWIST2 Hs00382379_m1 AF322916 UACA Hs00326052_m1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 NM_014909 VASH1 Hs00208609_m1 D32039 VCAN Hs01007941_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_014000 VCL Hs00243320_m1 NM_003377 VEGFB Hs00173634_m1 U58111 VEGFC Hs01099206_m1 NM_016206 VGLL3 Hs00275109_s1 NM_016206 VGLL3 Hs00275109_s1 NM_003380 VIM Hs00958116_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_152348 WDR81 Hs00400556_m1 NM_003387 WIPF1 Hs01076141_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003881 WISP2 Hs00180242_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_003391 WNT2 Hs00608224_m1 NM_015472 WWTR1 Hs00210007_m1 NM_145166 ZBTB47 Hs00908860_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 U12170 ZEB1 Hs01566407_m1 NM_014795 ZEB2 Hs00207691_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_024721 ZFHX4 Hs00257312_s1 NM_006887 ZFP36L2 Hs00272828_m1 170 NM_012082 ZFPM2 Hs00201397_m1 NM_022470 ZMAT3 Hs00223860_m1 NM_015069 ZNF423 Hs00323880_m1 NM_032772 ZNF503 Hs00262121_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 NM_024706 ZNF668 Hs00226767_m1 NM_001010972 ZYX Hs00170299_m1 NM_003461 ZYX Hs00170299_m1 COL6A3 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_007168 ABCA8 Hs00992371_m1 AB056106 ABI3BP Hs00248821_m1 NM_001613 ACTA2 Hs00426835_g1 M95178 ACTN1 Hs00998100_m1 BC003576 ACTN1 Hs00998100_m1 NM_001102 ACTN1 Hs00998100_m1 NM_001105 ACVR1 Hs00153836_m1 NM_000020 ACVRL1 Hs00163543_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_025220 ADAM33 Hs00296426_m1 NM_139056 ADAMTS16 Hs01049997_m1 NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_197941 ADAMTS6 Hs00812159_s1 AF284095 ADRA2A Hs00265081_s1 NM_001129 AEBP1 Hs00937468_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_006738 AKAP13 Hs00331658_s1 M90360 AKAP13 Hs00407844_m1 NM_005465 AKT3 Hs00289302_s1 NM_001034173 ALDH1L2 Hs00402876_m1 171 NM_130847 AMOTL1 Hs00294070_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_001148 ANK2 Hs00153998_m1 NM_054027 ANKH Hs00219798_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_000700 ANXA1 Hs00945401_m1 NM_003734 AOC3 Hs00186647_m1 NM_004308 ARHGAP1 Hs00188815_m1 NM_001025616 ARHGAP24 Hs01097580_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_005737 ARL4C Hs00255039_s1 NM_005737 ARL4C Hs00255039_s1 AF316824 ASPN Hs00214395_m1 NM_017680 ASPN Hs00214395_m1 NM_001003696 ATP5J Hs01081389_g1 NM_000332 ATXN1 Hs00165656_m1 NM_021913 AXL Hs01064444_m1 NM_012104 BACE1 Hs01123242_m1 NM_021813 BACH2 Hs00222364_m1 NM_152731 BEND6 Hs00288163_m1 NM_001711 BGN Hs00959143_m1 NM_001711 BGN Hs00959143_m1 BC002416 BGN Hs00959143_m1 NM_152414 BHLHE22 Hs01084964_s1 NM_017614 BHMT2 Hs00214120_m1 NM_017614 BHMT2 Hs00214120_m1 NM_006129 BMP1 Hs00196183_m1 NM_001199 BMP1 Hs00986789_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_032849 C13orf33 Hs00262558_m1 NM_030945 C1QTNF3 Hs00229569_m1 172 AF329841 C1QTNF5 Hs00363053_g1 NM_031910 C1QTNF6 Hs00230464_m1 AF329842 C1QTNF6 Hs00230464_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 NM_000064 C3 Hs00163811_m1 NM_004772 C5orf13 Hs00854282_g1 NM_004772 C5orf13 Hs00854282_g1 AF313413 C5orf62 Hs00383944_m1 NM_000722 CACNA2D1 Hs00984856_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 AF356193 CARD6 Hs01123611_m1 NM_001753 CAV1 Hs00971716_m1 NM_001753 CAV1 Hs00971716_m1 NM_001233 CAV2 Hs00184597_m1 NM_032040 CCDC8 Hs00540204_s1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_001759 CCND2 Hs00922419_g1 NM_020404 CD248 Hs00535586_s1 NM_012072 CD93 Hs00362607_m1 NM_002414 CD99 Hs00365982_m1 U82164 CD99 Hs00242853_m1 NM_002414 CD99 Hs00365982_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_001795 CDH5 Hs00901463_m1 NM_004936 CDKN2B Hs00793225_m1 NM_006561 CELF2 Hs00990166_m1 NM_016174 CERCAM Hs00170969_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_000204 CFI Hs00989715_m1 NM_003956 CH25H Hs02379634_s1 NM_018413 CHST11 Hs00218229_m1 NM_175856 CHSY3 Hs00545664_m1 NM_003613 CILP Hs00173647_m1 173 D86586 CLEC11A Hs00161544_m1 NM_002975 CLEC11A Hs00161544_m1 BC005810 CLEC11A Hs00161544_m1 BC005254 CLEC2B Hs00192860_m1 NM_024769 CLMP Hs00956750_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 NM_152495 CNIH3 Hs00379269_m1 NM_004368 CNN2 Hs00854264_s1 NM_015463 CNRIP1 Hs00384403_m1 NM_000493 COL10A1 Hs00166657_m1 NM_000493 COL10A1 Hs00166657_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 NM_001856 COL16A1 Hs00156876_m1 NM_030582 COL18A1 Hs01043425_g1 AF018081 COL18A1 Hs01043425_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 NM_000393 COL5A2 Hs00893923_m1 NM_015719 COL5A3 Hs00210526_m1 NM_015719 COL5A3 Hs00210526_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001849 COL6A2 Hs00242484_m1 AY029208 COL6A2 Hs00242484_m1 NM_001850 COL8A1 Hs00156669_m1 174 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_000095 COMP Hs00164359_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_001864 COX7A1 Hs00156989_m1 NM_019609 CPXM1 Hs01566704_g1 BC006393 CPZ Hs00186333_m1 AL136861 CRISPLD2 Hs00230322_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_138455 CTHRC1 Hs00298917_m1 NM_000396 CTSK Hs00166156_m1 NM_000609 CXCL12 Hs00930455_m1 NM_020311 CXCR7 Hs00664172_s1 NM_134268 CYGB Hs00370478_m1 NM_000104 CYP1B1 Hs00164383_m1 NM_000104 CYP1B1 Hs00164383_m1 AF003114 CYR61 Hs00998503_g1 NM_001554 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 BC003064 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_003737 DCHS1 Hs01044548_m1 NM_001920 DCN Hs00754870_s1 AF138303 DCN Hs00266491_m1 NM_001920 DCN Hs00754870_s1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_006182 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_004403 DFNA5 Hs00189346_m1 NM_000793 DIO2 Hs00255341_m1 NM_013989 DIO2 Hs00255341_m1 NM_014974 DIP2C Hs00324224_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 NM_006094 DLC1 Hs00183436_m1 175 AF026219 DLC1 Hs00931487_m1 NM_001005336 DNM1 Hs00189369_m1 M74777 DPP4 Hs00175210_m1 NM_001935 DPP4 Hs00175210_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001386 DPYSL2 Hs00954558_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_013352 DSE Hs00203441_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_001393 ECM2 Hs00154821_m1 NM_005711 EDIL3 Hs00174781_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_016938 EFEMP2 Hs00213545_m1 AB030655 EFEMP2 Hs00213545_m1 NM_001964 EGR1 Hs00152928_m1 NM_001964 EGR1 Hs00152928_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_020390 EIF5A2 Hs00702673_s1 NM_020390 EIF5A2 Hs00702673_s1 NM_005230 ELK3 Hs00987814_m1 NM_000501 ELN Hs01091772_m1 NM_022159 ELTD1 Hs03987598_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_004434 EML1 Hs00270014_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_001425 EMP3 Hs00171319_m1 NM_004098 EMX2 Hs00244574_m1 U87967 ENTPD1 Hs00969559_m1 NM_001776 ENTPD1 Hs00739960_s1 NM_001776 ENTPD1 Hs00739960_s1 NM_012156 EPB41L1 Hs00385004_m1 NM_004449 ERG Hs01554635_m1 NM_004956 ETV1 Hs00290469_s1 NM_147127 EVC2 Hs00377633_m1 NM_000129 F13A1 Hs00173388_m1 NM_001992 F2R Hs00169258_m1 176 NM_004101 F2RL2 Hs00187982_m1 NM_182705 FAM101B Hs00823804_m1 NM_182705 FAM101B Hs00823804_m1 NM_153711 FAM26E Hs00382139_m1 U76833 FAP Hs00990806_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001996 FBLN1 Hs00242546_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_006832 FERMT2 Hs01041255_m1 NM_006832 FERMT2 Hs01041255_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 NM_000800 FGF1 Hs00265254_m1 NM_003862 FGF18 Hs00818572_m1 AF063002 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 NM_014890 FILIP1L Hs00706279_s1 NM_017946 FKBP14 Hs00942521_m1 NM_017946 FKBP14 Hs00942521_m1 AF100751 FKBP7 Hs00535040_m1 NM_007270 FKBP9 Hs00414859_m1 NM_207422 FLJ44635 Hs00885839_s1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 AF169676 FLRT2 Hs00544171_s1 NM_013231 FLRT2 Hs00544171_s1 NM_002021 FMO1 Hs00266654_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 BC005858 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 AF130095 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_032532 FNDC1 Hs00287359_m1 177 NM_005253 FOSL2 Hs00232013_m1 NM_001452 FOXF2 Hs00230963_m1 NM_005197 FOXN3 Hs00830558_g1 NM_005197 FOXN3 Hs00830558_g1 NM_002015 FOXO1 Hs00231106_m1 NM_152330 FRMD6 Hs00378563_m1 NM_152330 FRMD6 Hs00378563_m1 NM_013409 FST Hs00246256_m1 NM_006350 FST Hs00246260_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_000148 FUT1 Hs00355741_m1 NM_015675 GADD45B Hs00169587_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 NM_000820 GAS6 Hs01090305_m1 L13720 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 NM_003644 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005261 GEM Hs00738924_m1 NM_005110 GFPT2 Hs01049561_m1 NM_004121 GGT5 Hs00269779_m1 NM_005266 GJA5 Hs00270952_s1 M86849 GJB2 Hs00269615_s1 NM_005270 GLI2 Hs00257977_m1 NM_006851 GLIPR1 Hs00199268_m1 NM_032575 GLIS2 Hs00402743_g1 NM_152629 GLIS3 Hs00295084_s1 NM_152629 GLIS3 Hs00295084_s1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_004126 GNG11 Hs00914578_m1 NM_018841 GNG12 Hs03005750_m1 NM_053064 GNG2 Hs00828232_m1 NM_014498 GOLIM4 Hs00274320_m1 AF111178 GPC6 Hs00170677_m1 NM_005708 GPC6 Hs00170677_m1 NM_002510 GPNMB Hs01095679_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_001008397 GPX8 Hs00380670_m1 AF154054 GREM1 Hs00171951_m1 178 NM_013372 GREM1 Hs00171951_m1 NM_002091 GRP Hs00181852_m1 NM_000177 GSN Hs00388617_m1 AF200715 GULP1 Hs00169604_m1 NM_016315 GULP1 Hs00169604_m1 NR_002196 H19 Hs00262142_g1 NR_002196 H19 Hs00262142_g1 NM_014799 HEPH Hs00953259_m1 NM_014571 HEYL Hs01113778_m1 NM_000601 HGF Hs00900066_m1 NM_031935 HMCN1 Hs00399043_m1 NM_016245 HSD17B11 Hs00212226_m1 NM_003725 HSD17B6 Hs00366258_m1 NM_052970 HSPA12B Hs00369554_m1 M85289 HSPG2 Hs01078536_m1 NM_002775 HTRA1 Hs01016151_m1 NM_053044 HTRA3 Hs01099710_m1 NM_053044 HTRA3 Hs01099710_m1 NM_002167 ID3 Hs00171409_m1 BC002857 IFFO1 Hs00209967_m1 NM_005531 IFI16 Hs00986755_m1 NM_020962 IGDCC4 Hs00326335_m1 M37484 IGF1 Hs01547657_m1 M29644 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_001007139 IGF2 Hs00277496_s1 NM_001552 IGFBP4 Hs00181767_m1 NM_002178 IGFBP6 Hs00942697_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_000877 IL1R1 Hs00991002_m1 NM_002192 INHBA Hs01081598_m1 M13436 INHBA Hs01081598_m1 NM_005545 ISLR Hs01921558_s1 AF109681 ITGA11 Hs01012939_m1 NM_002205 ITGA5 Hs01547673_m1 NM_002210 ITGAV Hs00233808_m1 NM_002211 ITGB1 Hs00236976_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 179 AF114488 ITSN1 Hs00161676_m1 NM_001001132 ITSN1 Hs00161676_m1 AF114488 ITSN1 Hs00161676_m1 NM_000214 JAG1 Hs01070036_m1 U73936 JAG1 Hs01070036_m1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_015493 KANK2 Hs00795260_m1 NM_181712 KANK4 Hs00400916_m1 AF160967 KCNMB4 Hs00205704_m1 NM_031954 KCTD10 Hs00230632_m1 NM_138444 KCTD12 Hs00540818_s1 NM_138444 KCTD12 Hs00540818_s1 NM_024089 KDELC1 Hs00607574_g1 NM_153705 KDELC2 Hs00794053_m1 NM_007035 KERA Hs00559942_m1 NM_019590 KIAA1217 Hs00289569_m1 NM_018012 KIF26B Hs00215977_m1 NM_018240 KIRREL Hs00217307_m1 NM_005655 KLF10 Hs00921811_m1 NM_003709 KLF7 Hs00748636_s1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002290 LAMA4 Hs00935293_m1 M20206 LAMB1 Hs01055971_m1 NM_002291 LAMB1 Hs01055971_m1 NM_002293 LAMC1 Hs00267056_m1 AF207547 LATS2 Hs00324396_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_001290 LDB2 Hs00609711_m1 NM_001003679 LEPR Hs00900242_m1 NM_022356 LEPRE1 Hs00223565_m1 NM_002305 LGALS1 Hs00355202_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_199000 LHFPL3 Hs01585188_s1 NM_016357 LIMA1 Hs00212557_m1 NM_153713 LIX1L Hs00542269_m1 NM_014583 LMCD1 Hs00205871_m1 NM_012134 LMOD1 Hs00201704_m1 NM_002317 LOX Hs00942480_m1 NM_002317 LOX Hs00942480_m1 NM_005576 LOXL1 Hs00935937_m1 180 NM_002318 LOXL2 Hs00158757_m1 NM_001401 LPAR1 Hs00173500_m1 NM_001401 LPAR1 Hs00173500_m1 NM_015116 LRCH1 Hs00996581_m1 NM_020871 LRCH2 Hs00325819_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_130830 LRRC15 Hs00370056_s1 NM_005824 LRRC17 Hs00180581_m1 NM_005512 LRRC32 Hs00194136_m1 AF113211 LTBP2 Hs00544640_s1 NM_000428 LTBP2 Hs00544640_s1 NM_002345 LUM Hs00158940_m1 NM_002345 LUM Hs00158940_m1 NM_033631 LUZP1 Hs00612276_m1 NM_005461 MAFB Hs00271378_s1 NM_005461 MAFB Hs00271378_s1 NM_019066 MAGEL2 Hs00255922_s1 NM_005907 MAN1A1 Hs00195458_m1 NM_002373 MAP1A Hs00357973_m1 M64571 MAP4 Hs00159048_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_004834 MAP4K4 Hs00377415_m1 BC004995 MARVELD1 Hs00230362_m1 NM_002381 MATN3 Hs00159081_m1 NM_017459 MFAP2 Hs01027737_m1 NM_002404 MFAP4 Hs00412974_m1 U37283 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_014632 MICAL2 Hs01121806_m1 NM_014632 MICAL2 Hs01121806_m1 NM_000248 MITF Hs01117294_m1 NM_000248 MITF Hs01117294_m1 NM_005940 MMP11 Hs00171829_m1 NM_005940 MMP11 Hs00171829_m1 NM_002427 MMP13 Hs00942589_m1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 AL136588 MMP16 Hs00540314_s1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 181 NM_002422 MMP3 Hs00968308_m1 NM_002430 MN1 Hs00159202_m1 NM_006039 MRC2 Hs00195862_m1 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 AF245505 MXRA5 Hs00295630_s1 NM_001008528 MXRA7 Hs00895155_m1 NM_001008528 MXRA7 Hs00895155_m1 NM_032348 MXRA8 Hs00260584_m1 NM_002473 MYH9 Hs00159522_m1 NM_006097 MYL9 Hs00697086_m1 NM_004998 MYO1E Hs00192232_m1 NM_052867 NALCN Hs00291166_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_005380 NBL1 Hs00185054_m1 NM_005380 NBL1 Hs00185054_m1 U35139 NDN Hs00267349_s1 NM_173808 NEGR1 Hs01584331_m1 NM_173808 NEGR1 Hs01584331_m1 NM_144573 NEXN Hs00332124_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_007361 NID2 Hs01547198_g1 NM_016533 NINJ2 Hs00356576_m1 NM_033120 NKD2 Hs00263909_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_024408 NOTCH2 Hs01050720_mH NM_024408 NOTCH2 Hs01050720_mH NM_016931 NOX4 Hs01558199_m1 NM_016588 NRN1 Hs00213192_m1 AF145712 NRP1 Hs00826121_m1 NM_001024628 NRP1 Hs00826121_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_002526 NT5E Hs01573922_m1 NM_016522 NTM Hs00275411_m1 NM_016522 NTM Hs00275411_m1 NM_014840 NUAK1 Hs00934234_m1 NM_019094 NUDT4 Hs00819603_m1 NM_014057 OGN Hs00247901_m1 182 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_015441 OLFML2B Hs00827139_g1 NM_020190 OLFML3 Hs00220180_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_003999 OSMR Hs00187782_m1 NM_182904 P4HA3 Hs00420085_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_000919 PAM Hs00168596_m1 NM_000919 PAM Hs00168596_m1 NM_002581 PAPPA Hs00545593_s1 AF237771 PARVA Hs00217177_m1 NM_018222 PARVA Hs00217177_m1 NM_019035 PCDH18 Hs00251855_m1 AB006757 PCDH7 Hs00361092_m1 NM_002589 PCDH7 Hs00159908_m1 AF152318 PCDHGA1 Hs00251717_m1 NM_002588 PCDHGC3 Hs00251717_m1 BC006439 PCDHGC3 Hs00251717_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_016205 PDGFC Hs00211916_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 NM_021630 PDLIM2 Hs00222154_m1 NM_005451 PDLIM7 Hs01103929_g1 NM_001006624 PDPN Hs01089982_g1 NM_006474 PDPN Hs01089982_g1 NM_001006624 PDPN Hs01089982_g1 NM_015009 PDZRN3 Hs00392900_m1 NM_015157 PHLDB1 Hs00384827_m1 NM_000297 PKD2 Hs00165517_m1 NM_001007267 PLA2R1 Hs00234853_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_006718 PLAGL1 Hs00414677_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_002656 PLAGL1 Hs00243030_m1 K03226 PLAU Hs00170182_m1 NM_002658 PLAU Hs00170182_m1 183 NM_002667 PLN Hs00160179_m1 NM_005032 PLS3 Hs00192406_m1 NM_020353 PLSCR4 Hs00924823_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_032812 PLXDC2 Hs00262350_m1 NM_005761 PLXNC1 Hs00955621_m1 NM_020182 PMEPA1 Hs03987603_g1 NM_020182 PMEPA1 Hs03987603_g1 L03203 PMP22 Hs00165556_m1 NM_153703 PODN Hs00542259_m1 NM_006475 POSTN Hs01566750_m1 D13665 POSTN Hs01566750_m1 NM_001030059 PPAPDC1A Hs00404185_m1 BC006362 PPAPDC3 Hs00262043_m1 NM_003622 PPFIBP1 Hs00186240_m1 NM_000943 PPIC Hs00181460_m1 NM_000943 PPIC Hs00181460_m1 NM_001198 PRDM1 Hs00153357_m1 NM_012231 PRDM2 Hs00202013_m1 AF272898 PRDM6 Hs01373000_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_198859 PRICKLE2 Hs00291033_s1 NM_145040 PRKCDBP Hs00293638_m1 NM_002742 PRKD1 Hs00177037_m1 NM_000313 PROS1 Hs00165590_m1 NM_024841 PRR5L Hs00757785_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_020440 PTGFRN Hs01385989_m1 NM_007039 PTPN21 Hs00234784_m1 NM_002839 PTPRD Hs00295441_s1 NM_002841 PTPRG Hs00892788_m1 NM_002841 PTPRG Hs00892788_m1 NM_002845 PTPRM Hs00267809_m1 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 NM_006775 QKI Hs00287641_m1 NM_016277 RAB23 Hs00212407_m1 AF161486 RAB23 Hs00212407_m1 NM_006868 RAB31 Hs00199313_m1 AF183421 RAB31 Hs00199313_m1 NM_006868 RAB31 Hs00199313_m1 184 NM_015577 RAI14 Hs00210238_m1 BC000069 RARRES2 Hs00161209_g1 NM_007368 RASA3 Hs00183698_m1 NM_006909 RASGRF2 Hs00394798_m1 NM_014483 RBMS3 Hs00205567_m1 NM_005822 RCAN2 Hs00195165_m1 NM_001268 RCBTB2 Hs00154390_m1 NM_020650 RCN3 Hs00276633_m1 NM_020650 RCN3 Hs00276633_m1 NM_021111 RECK Hs01019179_m1 NM_005613 RGS4 Hs00194501_m1 NM_017821 RHBDL2 Hs00384848_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 AL136924 RIN2 Hs00610937_m1 NM_014746 RNF144A Hs00207267_m1 NM_001006932 RPS6KA2 Hs00179731_m1 D43968 RUNX1 Hs00231079_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001015051 RUNX2 Hs00298328_s1 NM_001015051 RUNX2 Hs00298328_s1 NM_002968 SALL1 Hs00231307_m1 NM_002968 SALL1 Hs00231307_m1 NM_153334 SCARF2 Hs00544847_m1 NM_001006946 SDC1 Hs00896425_g1 NM_006364 SEC23A Hs00197232_m1 NM_014933 SEC31A Hs00274601_m1 NM_003966 SEMA5A Hs01549381_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 NM_003013 SFRP2 Hs00293258_m1 AF311912 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_032291 SGIP1 Hs00260297_m1 AL136561 SGIP1 Hs00260297_m1 185 NM_152621 SGMS2 Hs00380453_m1 NM_001009555 SH3D19 Hs00296942_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_001017995 SH3PXD2B Hs00375183_s1 NM_006884 SHOX2 Hs01059691_m1 AF022654 SHOX2 Hs00243203_m1 NM_078483 SLC36A1 Hs01092773_m1 NM_152270 SLFN11 Hs00536981_m1 NM_004787 SLIT2 Hs00191193_m1 AF055585 SLIT2 Hs00191193_m1 NM_003062 SLIT3 Hs00171524_m1 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 NM_003068 SNAI2 Hs00950344_m1 NM_018013 SOBP Hs00215979_m1 NM_020777 SORCS2 Hs00325181_m1 NM_003118 SPARC Hs00277762_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_015535 SPATS2L Hs00274702_m1 AF231124 SPOCK1 Hs00270274_m1 AB051390 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_005841 SPRY1 Hs01083036_s1 NM_025106 SPSB1 Hs00228304_m1 NM_025106 SPSB1 Hs00228304_m1 NM_006307 SRPX Hs00196867_m1 NM_014467 SRPX2 Hs00997580_m1 NM_018984 SSH1 Hs00368014_m1 NM_005086 SSPN Hs00296706_s1 AL136756 SSPN Hs00296706_s1 NM_005086 SSPN Hs00296706_s1 NM_005418 ST5 Hs00936461_m1 NM_032528 ST6GAL2 Hs00290088_s1 NM_006873 STON1 Hs00538997_m1 NM_015170 SULF1 Hs00290918_m1 NM_015170 SULF1 Hs00290918_m1 NM_015170 SULF1 Hs00290918_m1 NM_018837 SULF2 Hs00378697_m1 NM_018837 SULF2 Hs00378697_m1 NM_003174 SVIL Hs00931028_m1 186 NM_033025 SYDE1 Hs00263581_m1 NM_024893 SYNDIG1 Hs00227616_m1 AF043290 SYNE1 Hs00941972_m1 NM_007286 SYNPO Hs00702468_s1 NM_080737 SYTL4 Hs00299039_m1 NM_006283 TACC1 Hs00180691_m1 NM_003186 TAGLN Hs00162558_m1 NM_014604 TAX1BP3 Hs00205924_m1 AF234997 TAX1BP3 Hs00205924_m1 NM_015079 TBC1D2B Hs00534954_m1 NM_152380 TBX15 Hs00537087_m1 NM_000192 TBX5 Hs00361155_m1 NM_152278 TCEAL7 Hs00385936_m1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_021961 TEAD1 Hs00744253_s1 BC000125 TGFB1 Hs00998133_m1 BC001830 TGFB1I1 Hs00210887_m1 J03241 TGFB3 Hs01086000_m1 NM_000358 TGFBI Hs03987596_s1 NM_003246 THBS1 Hs00962914_m1 NM_003247 THBS2 Hs01568063_m1 NM_003248 THBS4 Hs00170261_m1 NM_006288 THY1 Hs00264235_s1 NM_006288 THY1 Hs00264235_s1 AL161958 THY1 Hs00264235_s1 NM_005424 TIE1 Hs00892696_m1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 U67195 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_024600 TMEM204 Hs01061927_m1 NM_002160 TNC Hs01115664_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_018647 TNFRSF19 Hs00218634_m1 NM_003326 TNFSF4 Hs00967195_m1 187 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_022748 TNS3 Hs00224228_m1 NM_003289 TPM2 Hs00268540_m1 NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_024164 TPSB2 Hs02576518_gH NM_003596 TPST1 Hs00234324_m1 NM_012288 TRAM2 Hs00202213_m1 NM_007118 TRIO Hs00179276_m1 NM_003304 TRPC1 Hs00608195_m1 NM_003304 TRPC1 Hs00608195_m1 NM_020856 TSHZ3 Hs02379784_s1 AL136805 TSHZ3 Hs02379784_s1 NM_005725 TSPAN2 Hs00194836_m1 AB028966 TTC28 Hs01117728_m1 BC002654 TUBB6 Hs00603164_m1 NM_000474 TWIST1 Hs00361186_m1 NM_057179 TWIST2 Hs00382379_m1 AF322916 UACA Hs00326052_m1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 NM_014909 VASH1 Hs00208609_m1 D32039 VCAN Hs01007941_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_014000 VCL Hs00243320_m1 U58111 VEGFC Hs01099206_m1 NM_016206 VGLL3 Hs00275109_s1 NM_016206 VGLL3 Hs00275109_s1 NM_003380 VIM Hs00958116_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_003387 WIPF1 Hs01076141_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003881 WISP2 Hs00180242_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_003391 WNT2 Hs00608224_m1 NM_003392 WNT5A Hs00998537_m1 188 NM_015472 WWTR1 Hs00210007_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_030751 ZEB1 Hs01566407_m1 U12170 ZEB1 Hs01566407_m1 NM_014795 ZEB2 Hs00207691_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_024721 ZFHX4 Hs00257312_s1 NM_004926 ZFP36L1 Hs00245183_m1 NM_012082 ZFPM2 Hs00201397_m1 NM_015069 ZNF423 Hs00323880_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 NM_018181 ZNF532 Hs00539543_m1 CPA3 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') AB003476 AKAP12 Hs00374507_m1 NM_000689 ALDH1A1 Hs00167445_m1 NM_001148 ANK2 Hs00153998_m1 AF316824 ASPN Hs00214395_m1 NM_001003696 ATP5J Hs01081389_g1 NM_012261 C20orf103 Hs00935891_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_015463 CNRIP1 Hs00384403_m1 NM_021110 COL14A1 Hs00385388_m1 NM_001911 CTSG Hs00175195_m1 NM_000396 CTSK Hs00166156_m1 NM_001920 DCN Hs00754870_s1 AF138302 DCN Hs00370385_m1 AF138303 DCN Hs00266491_m1 NM_001920 DCN Hs00754870_s1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001393 ECM2 Hs00154821_m1 NM_004101 F2RL2 Hs00187982_m1 U76833 FAP Hs00990806_m1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_013231 FLRT2 Hs00544171_s1 BC006454 GAS7 Hs00932959_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_000601 HGF Hs00900066_m1 189 NM_014485 HPGDS Hs00183950_m1 NM_000867 HTR2B Hs00168362_m1 NM_000618 IGF1 Hs01547657_m1 NM_003856 IL1RL1 Hs00545038_g1 NM_004791 ITGBL1 Hs00191224_m1 NM_021219 JAM2 Hs01022013_m1 NM_000899 KITLG Hs00295067_s1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_005780 LHFP Hs00172961_m1 NM_016357 LIMA1 Hs00212557_m1 NM_005824 LRRC17 Hs00180581_m1 NM_002345 LUM Hs00158940_m1 NM_002404 MFAP4 Hs00412974_m1 D10583 MS4A2 Hs00175091_m1 NM_000139 MS4A2 Hs00175091_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_025208 PDGFD Hs00937332_m1 NM_153703 PODN Hs00542259_m1 NM_021111 RECK Hs01019179_m1 AF030107 RGS13 Hs00243182_m1 NM_003013 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 NM_004787 SLIT2 Hs00191193_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_152278 TCEAL7 Hs00385936_m1 J03241 TGFB3 Hs01086000_m1 NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_024164 TPSB2 Hs02576518_gH NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 U12170 ZEB1 Hs01566407_m1 190 CTSG Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_007168 ABCA8 Hs00992371_m1 NM_001148 ANK2 Hs00153998_m1 NM_003956 CH25H Hs02379634_s1 NM_145234 CHRDL1 Hs00292767_m1 NM_001836 CMA1 Hs00156558_m1 NM_001870 CPA3 Hs00157019_m1 NM_018659 CYTL1 Hs01573280_m1 NM_002036 DARC Hs01011079_s1 BC005912 FCER1A Hs00758600_m1 NM_005031 FXYD1 Hs00245327_m1 NM_004962 GDF10 Hs01086867_m1 NM_052970 HSPA12B Hs00369554_m1 NM_000618 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_178822 IGSF10 Hs00975906_m1 AB024518 IL33 Hs00369211_m1 AF128846 INMT Hs00198941_m1 NM_021219 JAM2 Hs01022013_m1 NM_000426 LAMA2 Hs01124081_m1 NM_006691 LYVE1 Hs00272659_m1 NM_004527 MEOX1 Hs00244943_m1 NM_002404 MFAP4 Hs00412974_m1 D10583 MS4A2 Hs00175091_m1 NM_000139 MS4A2 Hs00175091_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_153703 PODN Hs00542259_m1 NM_020663 RHOJ Hs00368156_m1 NM_173833 SCARA5 Hs01073151_m1 NM_004657 SDPR Hs00190538_m1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_024164 TPSB2 Hs02576518_gH DCN Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_000014 A2M Hs00163474_m1 191 NM_080284 ABCA6 Hs00365329_m1 NM_007168 ABCA8 Hs00992371_m1 NM_080283 ABCA9 Hs00329320_m1 AB056106 ABI3BP Hs00248821_m1 NM_001033583 ACOT9 Hs00202482_m1 NM_001613 ACTA2 Hs00426835_g1 NM_001102 ACTN1 Hs00998100_m1 NM_001105 ACVR1 Hs00153836_m1 NM_001616 ACVR2A Hs00155658_m1 NM_000020 ACVRL1 Hs00163543_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_025220 ADAM33 Hs00296426_m1 NM_139056 ADAMTS16 Hs01049997_m1 NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_197941 ADAMTS6 Hs00812159_s1 NM_015833 ADARB1 Hs00953724_m1 NM_019903 ADD3 Hs00249890_m1 NM_001121 ADD3 Hs00249890_m1 M24317 ADH1B Hs00605175_m1 M21692 ADH1B Hs00605175_m1 AF284095 ADRA2A Hs00265081_s1 NM_001129 AEBP1 Hs00937468_m1 NM_006796 AFG3L2 Hs00255224_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_006738 AKAP13 Hs00331658_s1 M90360 AKAP13 Hs00407844_m1 NM_005465 AKT3 Hs00289302_s1 NM_005465 AKT3 Hs00289302_s1 NM_000689 ALDH1A1 Hs00167445_m1 NM_001034173 ALDH1L2 Hs00402876_m1 NM_130847 AMOTL1 Hs00294070_m1 NM_004673 ANGPTL1 Hs00559786_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 192 NM_012098 ANGPTL2 Hs00765775_m1 NM_001148 ANK2 Hs00153998_m1 NM_054027 ANKH Hs00219798_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_001025356 ANO6 Hs01374899_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_000700 ANXA1 Hs00945401_m1 NM_003734 AOC3 Hs00186647_m1 NM_153000 APCDD1 Hs00537787_m1 NM_020809 ARHGAP20 Hs00826991_m1 NM_001025616 ARHGAP24 Hs01097580_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_032199 ARID5B Hs01382781_m1 NM_005737 ARL4C Hs00255039_s1 AF316824 ASPN Hs00214395_m1 NM_017680 ASPN Hs00214395_m1 NM_020453 ATP10D Hs00935004_m1 NM_001003696 ATP5J Hs01081389_g1 NM_001003803 ATP5S Hs00210402_m1 NM_000332 ATXN1 Hs00165656_m1 NM_021913 AXL Hs01064444_m1 NM_012104 BACE1 Hs01123242_m1 NM_021813 BACH2 Hs00222364_m1 NM_152731 BEND6 Hs00288163_m1 NM_001711 BGN Hs00959143_m1 BC002416 BGN Hs00959143_m1 NM_152414 BHLHE22 Hs01084964_s1 NM_030762 BHLHE41 Hs00229146_m1 NM_017614 BHMT2 Hs00214120_m1 NM_017614 BHMT2 Hs00214120_m1 NM_001199 BMP1 Hs00986789_m1 NM_006129 BMP1 Hs00196183_m1 NM_001204 BMPR2 Hs00176148_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_033254 BOC Hs00264408_m1 AL136653 C10orf10 Hs00199735_m1 193 NM_017787 C10orf26 Hs00740771_s1 NM_014059 C13orf15 Hs00204129_m1 NM_032849 C13orf33 Hs00262558_m1 NM_030945 C1QTNF3 Hs00229569_m1 AF329841 C1QTNF5 Hs00363053_g1 AF329842 C1QTNF6 Hs00230464_m1 NM_031911 C1QTNF7 Hs00230467_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 NM_000064 C3 Hs00163811_m1 NM_015224 C3orf63 Hs00248615_m1 NM_004772 C5orf13 Hs00854282_g1 NM_001007189 C5orf53 Hs00759532_s1 AF313413 C5orf62 Hs00383944_m1 NM_183373 C6orf145 Hs00406043_m1 NM_024913 C7orf58 Hs00227735_m1 NM_032823 C9orf3 Hs01051467_m1 NM_020925 CACHD1 Hs00326087_m1 NM_000722 CACNA2D1 Hs00984856_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_015916 CALHM2 Hs00374996_m1 AF356193 CARD6 Hs01123611_m1 NM_001753 CAV1 Hs00971716_m1 NM_001753 CAV1 Hs00971716_m1 NM_001233 CAV2 Hs00184597_m1 NM_001233 CAV2 Hs00184597_m1 AL136562 CCDC3 Hs00230222_m1 NM_174908 CCDC50 Hs00291696_s1 AL136609 CCDC8 Hs00540204_s1 NM_032040 CCDC8 Hs00540204_s1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_001759 CCND2 Hs00922419_g1 NM_016557 CCRL1 Hs00664347_s1 AF063591 CD200 Hs01033303_m1 NM_020404 CD248 Hs00535586_s1 NM_014880 CD302 Hs00208436_m1 NM_012072 CD93 Hs00362607_m1 U82164 CD99 Hs00242853_m1 NM_002414 CD99 Hs00365982_m1 194 NM_003671 CDC14B Hs00269351_m1 NM_145057 CDC42EP5 Hs01936746_s1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_001795 CDH5 Hs00901463_m1 NM_012395 CDK14 Hs00202633_m1 NM_000076 CDKN1C Hs00175938_m1 NM_004936 CDKN2B Hs00793225_m1 NM_001801 CDO1 Hs00156447_m1 NM_001025076 CELF2 Hs00990166_m1 U69546 CELF2 Hs00990166_m1 NM_006561 CELF2 Hs00990166_m1 NM_016174 CERCAM Hs00170969_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_000204 CFI Hs00989715_m1 NM_003956 CH25H Hs02379634_s1 NM_006614 CHL1 Hs00544069_m1 NM_145234 CHRDL1 Hs00292767_m1 NM_018413 CHST11 Hs00218229_m1 NM_175856 CHSY3 Hs00545664_m1 NM_003613 CILP Hs00173647_m1 NM_005602 CLDN11 Hs00194440_m1 D86586 CLEC11A Hs00161544_m1 NM_002975 CLEC11A Hs00161544_m1 BC005810 CLEC11A Hs00161544_m1 BC005254 CLEC2B Hs00192860_m1 NM_013943 CLIC4 Hs00749895_s1 NM_024769 CLMP Hs00956750_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 NM_001299 CNN1 Hs00154543_m1 NM_004368 CNN2 Hs00854264_s1 NM_015463 CNRIP1 Hs00384403_m1 NM_000493 COL10A1 Hs00166657_m1 NM_000493 COL10A1 Hs00166657_m1 NM_001854 COL11A1 Hs01097664_m1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 195 NM_001856 COL16A1 Hs00156876_m1 NM_030582 COL18A1 Hs01043425_g1 AF018081 COL18A1 Hs01043425_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 NM_000393 COL5A2 Hs00893923_m1 NM_015719 COL5A3 Hs00210526_m1 NM_015719 COL5A3 Hs00210526_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 AY029208 COL6A2 Hs00242484_m1 NM_001849 COL6A2 Hs00242484_m1 NM_004369 COL6A3 Hs00915120_m1 NM_001850 COL8A1 Hs00156669_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_000095 COMP Hs00164359_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_001864 COX7A1 Hs00156989_m1 NM_001864 COX7A1 Hs00156989_m1 NM_001870 CPA3 Hs00157019_m1 NM_001873 CPE Hs00175676_m1 NM_153634 CPNE8 Hs00402394_m1 NM_019609 CPXM1 Hs01566704_g1 NM_198148 CPXM2 Hs00406866_m1 BC006393 CPZ Hs00186333_m1 AL136861 CRISPLD2 Hs00230322_m1 NM_018371 CSGALNACT1 Hs00218054_m1 NM_018590 CSGALNACT2 Hs00603821_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_138455 CTHRC1 Hs00298917_m1 196 NM_000396 CTSK Hs00166156_m1 NM_001334 CTSO Hs00154656_m1 U20350 CX3CR1 Hs01922583_s1 NM_000609 CXCL12 Hs00930455_m1 NM_020311 CXCR7 Hs00664172_s1 AL136693 CYBRD1 Hs00227411_m1 NM_134268 CYGB Hs00370478_m1 NM_000104 CYP1B1 Hs00164383_m1 NM_000104 CYP1B1 Hs00164383_m1 NM_000104 CYP1B1 Hs00164383_m1 NM_183075 CYP2U1 Hs00766273_m1 AF003114 CYR61 Hs00998503_g1 NM_001554 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 BC003064 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_003737 DCHS1 Hs01044548_m1 NM_001920 DCN Hs00754870_s1 AF138303 DCN Hs00266491_m1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_006182 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_004403 DFNA5 Hs00189346_m1 NM_000793 DIO2 Hs00255341_m1 NM_013989 DIO2 Hs00255341_m1 NM_014974 DIP2C Hs00324224_m1 NM_033425 DIXDC1 Hs00736707_m1 NM_014421 DKK2 Hs00205294_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 AF026219 DLC1 Hs00931487_m1 NM_006094 DLC1 Hs00183436_m1 NM_001005336 DNM1 Hs00189369_m1 NM_144658 DOCK11 Hs00376176_m1 NM_014705 DOCK4 Hs00206807_m1 M74777 DPP4 Hs00175210_m1 NM_001935 DPP4 Hs00175210_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 197 NM_001937 DPT Hs00355056_m1 NM_000110 DPYD Hs02510591_s1 NM_001386 DPYSL2 Hs00954558_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_013352 DSE Hs00203441_m1 NM_032160 DSEL Hs00707488_s1 NM_014934 DZIP1 Hs00208790_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_001005463 EBF3 Hs00291943_s1 NM_001393 ECM2 Hs00154821_m1 NM_005711 EDIL3 Hs00174781_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 AB030655 EFEMP2 Hs00213545_m1 NM_016938 EFEMP2 Hs00213545_m1 NM_181723 EFHA2 Hs01028469_m1 NM_001964 EGR1 Hs00152928_m1 NM_001964 EGR1 Hs00152928_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_020390 EIF5A2 Hs00702673_s1 NM_020390 EIF5A2 Hs00702673_s1 NM_005230 ELK3 Hs00987814_m1 NM_000501 ELN Hs01091772_m1 NM_022159 ELTD1 Hs03987598_m1 NM_016242 EMCN Hs01038209_m1 NM_016242 EMCN Hs01038209_m1 AF205940 EMCN Hs01038209_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_001008707 EML1 Hs00270014_m1 NM_004434 EML1 Hs00270014_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_004098 EMX2 Hs00244574_m1 U87967 ENTPD1 Hs00969559_m1 NM_001776 ENTPD1 Hs00739960_s1 NM_001776 ENTPD1 Hs00739960_s1 NM_001430 EPAS1 Hs01026142_m1 NM_012156 EPB41L1 Hs00385004_m1 NM_001431 EPB41L2 Hs00154988_m1 198 NM_001981 EPS15 Hs00179978_m1 NM_004449 ERG Hs01554635_m1 NM_004956 ETV1 Hs00290469_s1 NM_147127 EVC2 Hs00377633_m1 NM_014210 EVI2A Hs00204405_m1 NM_000129 F13A1 Hs00173388_m1 NM_001992 F2R Hs00169258_m1 NM_004101 F2RL2 Hs00187982_m1 NM_182705 FAM101B Hs00823804_m1 NM_182705 FAM101B Hs00823804_m1 NM_032581 FAM126A Hs00261521_m1 NM_153711 FAM26E Hs00382139_m1 U76833 FAP Hs00990806_m1 NM_000043 FAS Hs00907759_m1 NM_000043 FAS Hs00907759_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001996 FBLN1 Hs00242546_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_012158 FBXL3 Hs01045265_m1 BC005912 FCER1A Hs00758600_m1 NM_006832 FERMT2 Hs01041255_m1 NM_006832 FERMT2 Hs01041255_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 NM_005102 FEZ2 Hs00170585_m1 NM_000800 FGF1 Hs00265254_m1 NM_003862 FGF18 Hs00818572_m1 U29538 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 AF098518 FHL1 Hs00793641_g1 AF063002 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 NM_014890 FILIP1L Hs00706279_s1 NM_017946 FKBP14 Hs00942521_m1 NM_017946 FKBP14 Hs00942521_m1 AF100751 FKBP7 Hs00535040_m1 199 NM_007270 FKBP9 Hs00414859_m1 NM_002017 FLI1 Hs00956711_m1 NM_207422 FLJ44635 Hs00885839_s1 AF169676 FLRT2 Hs00544171_s1 NM_013231 FLRT2 Hs00544171_s1 NM_002021 FMO1 Hs00266654_m1 NM_002023 FMOD Hs00157619_m1 AF130095 FN1 Hs00415006_m1 BC005858 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_032532 FNDC1 Hs00287359_m1 NM_001452 FOXF2 Hs00230963_m1 NM_005197 FOXN3 Hs00830558_g1 NM_005197 FOXN3 Hs00830558_g1 NM_002015 FOXO1 Hs00231106_m1 NM_002015 FOXO1 Hs00231106_m1 NM_144966 FREM1 Hs00381549_m1 NM_152330 FRMD6 Hs00378563_m1 NM_152330 FRMD6 Hs00378563_m1 NM_001463 FRZB Hs00173503_m1 U91903 FRZB Hs00173503_m1 NM_013409 FST Hs00246256_m1 NM_006350 FST Hs00246260_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_000148 FUT1 Hs00355741_m1 NM_005031 FXYD1 Hs00245327_m1 M14333 FYN Hs00941600_m1 NM_002037 FYN Hs00941600_m1 NM_003505 FZD1 Hs00268943_s1 NM_003507 FZD7 Hs00275833_s1 NM_015675 GADD45B Hs00169587_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 L13720 GAS6 Hs01090305_m1 NM_000820 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 NM_003644 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005261 GEM Hs00738924_m1 NM_005110 GFPT2 Hs01049561_m1 200 NM_004121 GGT5 Hs00269779_m1 NM_005266 GJA5 Hs00270952_s1 M86849 GJB2 Hs00269615_s1 NM_005270 GLI2 Hs00257977_m1 NM_006851 GLIPR1 Hs00199268_m1 NM_006851 GLIPR1 Hs00199268_m1 NM_032575 GLIS2 Hs00402743_g1 NM_152629 GLIS3 Hs00295084_s1 NM_018446 GLT8D1 Hs00251197_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_004126 GNG11 Hs00914578_m1 NM_018841 GNG12 Hs03005750_m1 NM_053064 GNG2 Hs00828232_m1 NM_014498 GOLIM4 Hs00274320_m1 NM_005708 GPC6 Hs00170677_m1 NM_002510 GPNMB Hs01095679_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_198827 GPR133 Hs00914797_m1 AF039686 GPR34 Hs00271105_s1 NM_014710 GPRASP1 Hs01932892_s1 NM_015696 GPX7 Hs00210410_m1 NM_001008397 GPX8 Hs00380670_m1 NM_023927 GRAMD3 Hs00225077_m1 AF154054 GREM1 Hs00171951_m1 NM_013372 GREM1 Hs00171951_m1 NM_002091 GRP Hs00181852_m1 NM_000177 GSN Hs00388617_m1 NM_016315 GULP1 Hs00169604_m1 AF200715 GULP1 Hs00169604_m1 NM_016315 GULP1 Hs00169604_m1 NR_002196 H19 Hs00262142_g1 NR_002196 H19 Hs00262142_g1 NM_014799 HEPH Hs00953259_m1 NM_000601 HGF Hs00900066_m1 NM_031935 HMCN1 Hs00399043_m1 NM_006895 HNMT Hs00199373_m1 NM_001024074 HNMT Hs02759756_s1 NM_016245 HSD17B11 Hs00212226_m1 NM_003725 HSD17B6 Hs00366258_m1 NM_052970 HSPA12B Hs00369554_m1 M85289 HSPG2 Hs01078536_m1 NM_000867 HTR2B Hs00168362_m1 NM_002775 HTRA1 Hs01016151_m1 201 NM_053044 HTRA3 Hs01099710_m1 NM_053044 HTRA3 Hs01099710_m1 NM_002167 ID3 Hs00171409_m1 BC002857 IFFO1 Hs00209967_m1 AF208043 IFI16 Hs00194261_m1 NM_005531 IFI16 Hs00986755_m1 NM_020962 IGDCC4 Hs00326335_m1 M37484 IGF1 Hs01547657_m1 M29644 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_000612 IGF2 Hs00277496_s1 NM_001007139 IGF2 Hs00277496_s1 M31159 IGFBP3 Hs00181211_m1 NM_002178 IGFBP6 Hs00942697_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_153687 IKBIP Hs00291515_m1 NM_138284 IL17D Hs00370528_m1 NM_000877 IL1R1 Hs00991002_m1 M13436 INHBA Hs01081598_m1 NM_002192 INHBA Hs01081598_m1 NM_005545 ISLR Hs01921558_s1 AF109681 ITGA11 Hs01012939_m1 NM_002210 ITGAV Hs00233808_m1 NM_002211 ITGB1 Hs00236976_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_030569 ITIH5 Hs00262393_s1 NM_004867 ITM2A Hs01011360_g1 NM_004867 ITM2A Hs01011360_g1 AF092128 ITM2B Hs01126287_m1 NM_021999 ITM2B Hs01126287_m1 AF114488 ITSN1 Hs00161676_m1 NM_001001132 ITSN1 Hs00161676_m1 AF114488 ITSN1 Hs00161676_m1 NM_000214 JAG1 Hs01070036_m1 U73936 JAG1 Hs01070036_m1 NM_002227 JAK1 Hs01026996_m1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_175061 JAZF1 Hs00697777_m1 202 NM_015493 KANK2 Hs00795260_m1 AF160967 KCNMB4 Hs00205704_m1 NM_031954 KCTD10 Hs00230632_m1 NM_138444 KCTD12 Hs00540818_s1 NM_138444 KCTD12 Hs00540818_s1 NM_024089 KDELC1 Hs00607574_g1 NM_153705 KDELC2 Hs00794053_m1 NM_007035 KERA Hs00559942_m1 NM_019590 KIAA1217 Hs00289569_m1 NM_018240 KIRREL Hs00217307_m1 NM_005655 KLF10 Hs00921811_m1 NM_007249 KLF12 Hs00273134_m1 NM_016270 KLF2 Hs00360439_g1 NM_001206 KLF9 Hs00230918_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002290 LAMA4 Hs00935293_m1 M20206 LAMB1 Hs01055971_m1 NM_002291 LAMB1 Hs01055971_m1 NM_002293 LAMC1 Hs00267056_m1 AF207547 LATS2 Hs00324396_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_001290 LDB2 Hs00609711_m1 NM_001003679 LEPR Hs00900242_m1 NM_001003679 LEPR Hs00900242_m1 U50748 LEPR Hs00900242_m1 NM_022356 LEPRE1 Hs00223565_m1 NM_002305 LGALS1 Hs00355202_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_199000 LHFPL3 Hs01585188_s1 BC001247 LIMA1 Hs00212557_m1 NM_016357 LIMA1 Hs00212557_m1 NM_017980 LIMS2 Hs01002880_gH NM_153713 LIX1L Hs00542269_m1 NM_005574 LMO2 Hs00277106_m1 NM_012134 LMOD1 Hs00201704_m1 NM_002317 LOX Hs00942480_m1 NM_002317 LOX Hs00942480_m1 NM_005576 LOXL1 Hs00935937_m1 NM_002318 LOXL2 Hs00158757_m1 NM_001401 LPAR1 Hs00173500_m1 NM_001401 LPAR1 Hs00173500_m1 203 NM_005767 LPAR6 Hs00271758_s1 NM_017839 LPCAT2 Hs00215225_m1 NM_015116 LRCH1 Hs00996581_m1 NM_020871 LRCH2 Hs00325819_m1 NM_153377 LRIG3 Hs00957485_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_130830 LRRC15 Hs00370056_s1 NM_005824 LRRC17 Hs00180581_m1 NM_005512 LRRC32 Hs00194136_m1 BC004958 LRRFIP1 Hs00384213_m1 AF113211 LTBP2 Hs00544640_s1 NM_000428 LTBP2 Hs00544640_s1 NM_002345 LUM Hs00158940_m1 NM_002345 LUM Hs00158940_m1 NM_033631 LUZP1 Hs00612276_m1 NM_033631 LUZP1 Hs00612276_m1 NM_015364 LY96 Hs00209771_m1 NM_005584 MAB21L1 Hs00366575_s1 NM_005461 MAFB Hs00271378_s1 NM_005461 MAFB Hs00271378_s1 NM_019066 MAGEL2 Hs00255922_s1 NM_153267 MAMDC2 Hs00299196_m1 NM_032427 MAML2 Hs00418423_m1 NM_005907 MAN1A1 Hs00195458_m1 NM_002373 MAP1A Hs00357973_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_006575 MAP4K5 Hs00179088_m1 BC004995 MARVELD1 Hs00230362_m1 NM_002381 MATN3 Hs00159081_m1 NM_021038 MBNL1 Hs00253287_m1 AF054589 MDFIC Hs00611472_m1 NM_002397 MEF2C Hs00231149_m1 NM_002398 MEIS1 Hs01017441_m1 NM_005924 MEOX2 Hs00232248_m1 NM_017459 MFAP2 Hs01027737_m1 NM_002404 MFAP4 Hs00412974_m1 U37283 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_014632 MICAL2 Hs01121806_m1 NM_000248 MITF Hs01117294_m1 NM_000248 MITF Hs01117294_m1 NM_007287 MME Hs00153519_m1 204 NM_000902 MME Hs00153519_m1 AL136588 MMP16 Hs00540314_s1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 NM_002422 MMP3 Hs00968308_m1 NM_002430 MN1 Hs00159202_m1 NM_024761 MOBKL2B Hs00257351_m1 NM_024761 MOBKL2B Hs00257351_m1 NM_006791 MORF4L1 Hs01655230_s1 NM_023075 MPPE1 Hs00372745_g1 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 AF245505 MXRA5 Hs00295630_s1 NM_001008528 MXRA7 Hs00895155_m1 NM_001008528 MXRA7 Hs00895155_m1 NM_032348 MXRA8 Hs00260584_m1 NM_006097 MYL9 Hs00697086_m1 NM_004998 MYO1E Hs00192232_m1 NM_052867 NALCN Hs00291166_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_005380 NBL1 Hs00185054_m1 NM_005380 NBL1 Hs00185054_m1 U35139 NDN Hs00267349_s1 NM_022351 NECAB1 Hs00332733_m1 NM_006154 NEDD4 Hs00406454_m1 NM_173808 NEGR1 Hs01584331_m1 NM_173808 NEGR1 Hs01584331_m1 NM_144573 NEXN Hs00332124_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_007361 NID2 Hs01547198_g1 NM_016533 NINJ2 Hs00356576_m1 NM_033120 NKD2 Hs00263909_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_024408 NOTCH2 Hs01050720_mH NM_024408 NOTCH2 Hs01050720_mH NM_002514 NOV Hs00159631_m1 NM_016931 NOX4 Hs01558199_m1 NM_005654 NR2F1 Hs00818842_m1 X03348 NR3C1 Hs00354508_m1 NM_016588 NRN1 Hs00213192_m1 205 NM_001024628 NRP1 Hs00826121_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_002526 NT5E Hs01573922_m1 NM_002526 NT5E Hs01573922_m1 NM_016522 NTM Hs00275411_m1 AF278532 NTN4 Hs00221915_m1 NM_014840 NUAK1 Hs00934234_m1 NM_019094 NUDT4 Hs00819603_m1 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_015441 OLFML2B Hs00827139_g1 NM_020190 OLFML3 Hs00220180_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_003999 OSMR Hs00187782_m1 NM_182904 P4HA3 Hs00420085_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_017734 PALMD Hs00214675_m1 NM_000919 PAM Hs00168596_m1 NM_000919 PAM Hs00168596_m1 NM_173462 PAPLN Hs00404545_m1 NM_002581 PAPPA Hs00545593_s1 NM_002581 PAPPA Hs00545593_s1 NM_057177 PARD3B Hs00365140_m1 AF237771 PARVA Hs00217177_m1 NM_018222 PARVA Hs00217177_m1 NM_019035 PCDH18 Hs00251855_m1 AB006757 PCDH7 Hs00361092_m1 NM_002589 PCDH7 Hs00159908_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_005019 PDE1A Hs00897273_m1 NM_000921 PDE3A Hs01012698_m1 NM_018945 PDE7B Hs01054008_m1 NM_016205 PDGFC Hs00211916_m1 NM_025208 PDGFD Hs00937332_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 206 NM_021630 PDLIM2 Hs00222154_m1 NM_005451 PDLIM7 Hs01103929_g1 NM_006474 PDPN Hs01089982_g1 NM_001006624 PDPN Hs01089982_g1 NM_001006624 PDPN Hs01089982_g1 AF338650 PDZD2 Hs00389477_m1 NM_015009 PDZRN3 Hs00392900_m1 NM_000442 PECAM1 Hs00169777_m1 NM_000442 PECAM1 Hs00169777_m1 NM_021255 PELI2 Hs01012262_mH NM_021965 PGM5 Hs00222671_m1 NM_014721 PHACTR2 Hs01112111_m1 NM_015157 PHLDB1 Hs00384827_m1 NM_145753 PHLDB2 Hs00377503_m1 NM_017933 PID1 Hs00952182_m1 NM_000297 PKD2 Hs00165517_m1 NM_001007267 PLA2R1 Hs00234853_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_006718 PLAGL1 Hs00414677_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_015184 PLCL2 Hs00392897_m1 NM_002667 PLN Hs00160179_m1 NM_002667 PLN Hs00160179_m1 NM_005032 PLS3 Hs00192406_m1 NM_020353 PLSCR4 Hs00924823_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_032812 PLXDC2 Hs00262350_m1 NM_005761 PLXNC1 Hs00955621_m1 NM_020182 PMEPA1 Hs03987603_g1 L03203 PMP22 Hs00165556_m1 NM_153703 PODN Hs00542259_m1 NM_006475 POSTN Hs01566750_m1 D13665 POSTN Hs01566750_m1 AB000888 PPAP2A Hs00170356_m1 AF014403 PPAP2A Hs00170356_m1 AB000889 PPAP2B Hs00170359_m1 NM_003713 PPAP2B Hs00170359_m1 NM_003713 PPAP2B Hs00170359_m1 NM_001030059 PPAPDC1A Hs00404185_m1 BC006362 PPAPDC3 Hs00262043_m1 NM_003622 PPFIBP1 Hs00186240_m1 NM_000943 PPIC Hs00181460_m1 NM_000943 PPIC Hs00181460_m1 NM_001198 PRDM1 Hs00153357_m1 207 NM_012231 PRDM2 Hs00202013_m1 AF272898 PRDM6 Hs01373000_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_198859 PRICKLE2 Hs00291033_s1 NM_145040 PRKCDBP Hs00293638_m1 NM_002742 PRKD1 Hs00177037_m1 NM_000311 PRNP Hs01920617_s1 NM_000313 PROS1 Hs00165590_m1 NM_024841 PRR5L Hs00757785_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_000314 PTEN Hs01920652_s1 NM_000958 PTGER4 Hs00168761_m1 NM_020440 PTGFRN Hs01385989_m1 NM_000961 PTGIS Hs00919949_m1 NM_007039 PTPN21 Hs00234784_m1 NM_002837 PTPRB Hs01549049_m1 NM_002839 PTPRD Hs00295441_s1 NM_002841 PTPRG Hs00892788_m1 NM_002845 PTPRM Hs00267809_m1 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 NM_006775 QKI Hs00287641_m1 NM_006775 QKI Hs00287641_m1 NM_006775 QKI Hs00287641_m1 NM_006775 QKI Hs00287641_m1 AF161486 RAB23 Hs00212407_m1 NM_016277 RAB23 Hs00212407_m1 NM_006868 RAB31 Hs00199313_m1 AF183421 RAB31 Hs00199313_m1 NM_014247 RAPGEF2 Hs00248010_m1 BC000069 RARRES2 Hs00161209_g1 NM_007368 RASA3 Hs00183698_m1 NM_004841 RASAL2 Hs00183129_m1 NM_006909 RASGRF2 Hs00394798_m1 D28482 RBMS1 Hs00249930_s1 NM_002897 RBMS1 Hs00249930_s1 NM_002897 RBMS1 Hs00249930_s1 NM_014483 RBMS3 Hs00205567_m1 NM_005822 RCAN2 Hs00195165_m1 NM_001268 RCBTB2 Hs00154390_m1 208 NM_020650 RCN3 Hs00276633_m1 NM_020650 RCN3 Hs00276633_m1 NM_021111 RECK Hs01019179_m1 NM_144629 RFTN2 Hs00376096_m1 AF186779 RGL1 Hs00248508_m1 NM_017821 RHBDL2 Hs00384848_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 AL136924 RIN2 Hs00610937_m1 NM_021133 RNASEL Hs00221692_m1 NM_014746 RNF144A Hs00207267_m1 NM_001006932 RPS6KA2 Hs00179731_m1 D43968 RUNX1 Hs00231079_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001015051 RUNX2 Hs00298328_s1 NM_001015051 RUNX2 Hs00298328_s1 NM_002961 S100A4 Hs00243202_m1 NM_153334 SCARF2 Hs00544847_m1 NM_002976 SCN7A Hs00161546_m1 NM_001006946 SDC1 Hs00896425_g1 NM_006364 SEC23A Hs00197232_m1 NM_014933 SEC31A Hs00274601_m1 NM_003966 SEMA5A Hs01549381_m1 NM_005410 SEPP1 Hs00193657_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_015129 SEPT6 Hs00248408_m1 NM_001011553 SEPT7 Hs00792555_m1 NM_006216 SERPINE2 Hs00385730_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 NM_003013 SFRP2 Hs00293258_m1 AF311912 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 AL136561 SGIP1 Hs00260297_m1 209 NM_152621 SGMS2 Hs00380453_m1 NM_001009555 SH3D19 Hs00296942_m1 NM_016009 SH3GLB1 Hs00211220_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_001017995 SH3PXD2B Hs00375183_s1 NM_006884 SHOX2 Hs01059691_m1 AF022654 SHOX2 Hs00243203_m1 NM_003930 SKAP2 Hs00182698_m1 AL136944 SLC40A1 Hs00205888_m1 NM_152270 SLFN11 Hs00536981_m1 AF055585 SLIT2 Hs00191193_m1 NM_004787 SLIT2 Hs00191193_m1 AB011538 SLIT3 Hs00171524_m1 NM_003062 SLIT3 Hs00171524_m1 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 AB014737 SMOC2 Hs00405777_m1 NM_003068 SNAI2 Hs00950344_m1 NM_052870 SNX18 Hs00369367_s1 NM_018013 SOBP Hs00215979_m1 NM_014011 SOCS5 Hs00751962_s1 AL136896 SOCS5 Hs00367107_m1 NM_015385 SORBS1 Hs00908953_m1 NM_020777 SORCS2 Hs00325181_m1 NM_003118 SPARC Hs00277762_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_015535 SPATS2L Hs00274702_m1 AF231124 SPOCK1 Hs00270274_m1 AB051390 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_005841 SPRY1 Hs01083036_s1 NM_005842 SPRY2 Hs01921749_s1 NM_025106 SPSB1 Hs00228304_m1 NM_006307 SRPX Hs00196867_m1 NM_014467 SRPX2 Hs00997580_m1 NM_005086 SSPN Hs00296706_s1 AL136756 SSPN Hs00296706_s1 NM_005086 SSPN Hs00296706_s1 NM_005418 ST5 Hs00936461_m1 NM_032528 ST6GAL2 Hs00290088_s1 NM_006873 STON1 Hs00538997_m1 210 NM_015170 SULF1 Hs00290918_m1 NM_015170 SULF1 Hs00290918_m1 NM_018837 SULF2 Hs00378697_m1 NM_003174 SVIL Hs00931028_m1 AB014540 SWAP70 Hs00296255_s1 NM_033025 SYDE1 Hs00263581_m1 NM_024893 SYNDIG1 Hs00227616_m1 AF043290 SYNE1 Hs00941972_m1 NM_007286 SYNPO Hs00702468_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_005639 SYT1 Hs00194572_m1 NM_080737 SYTL4 Hs00299039_m1 NM_006283 TACC1 Hs00180691_m1 NM_006283 TACC1 Hs00180691_m1 NM_003186 TAGLN Hs00162558_m1 AF234997 TAX1BP3 Hs00205924_m1 NM_015079 TBC1D2B Hs00534954_m1 NM_152715 TBCEL Hs00378548_m1 NM_152380 TBX15 Hs00537087_m1 NM_000192 TBX5 Hs00361155_m1 NM_152278 TCEAL7 Hs00385936_m1 NM_003205 TCF12 Hs00918972_m1 NM_003205 TCF12 Hs00918972_m1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_000459 TEK Hs00945146_m1 BC001830 TGFB1I1 Hs00210887_m1 J03241 TGFB3 Hs01086000_m1 NM_003247 THBS2 Hs01568063_m1 NM_003248 THBS4 Hs00170261_m1 NM_006288 THY1 Hs00264235_s1 NM_006288 THY1 Hs00264235_s1 AL161958 THY1 Hs00264235_s1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 211 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_003257 TJP1 Hs00543824_m1 NM_004614 TK2 Hs00936918_m1 NM_007005 TLE4 Hs00276083_s1 NM_024600 TMEM204 Hs01061927_m1 AL136550 TMEM47 Hs00230190_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_018647 TNFRSF19 Hs00218634_m1 NM_022093 TNN Hs00295597_m1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_022748 TNS3 Hs00224228_m1 Z24727 TPM1 Hs00165966_m1 NM_003289 TPM2 Hs00268540_m1 NM_003294 TPSAB1 Hs02576518_gH NM_003294 TPSAB1 Hs02576518_gH NM_024164 TPSB2 Hs02576518_gH NM_003596 TPST1 Hs00234324_m1 NM_012288 TRAM2 Hs00202213_m1 NM_003304 TRPC1 Hs00608195_m1 NM_003304 TRPC1 Hs00608195_m1 NM_173485 TSHZ2 Hs00251507_s1 NM_173485 TSHZ2 Hs00251507_s1 NM_020856 TSHZ3 Hs02379784_s1 AL136805 TSHZ3 Hs02379784_s1 NM_005725 TSPAN2 Hs00194836_m1 AB028966 TTC28 Hs01117728_m1 BC002654 TUBB6 Hs00603164_m1 NM_000474 TWIST1 Hs00361186_m1 NM_057179 TWIST2 Hs00382379_m1 NM_020648 TWSG1 Hs00221028_m1 NM_006472 TXNIP Hs01006900_g1 NM_001008224 UACA Hs00326052_m1 AF322916 UACA Hs00326052_m1 NM_007106 UBL3 Hs01018736_g1 D32039 VCAN Hs01007941_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_014000 VCL Hs00243320_m1 U58111 VEGFC Hs01099206_m1 212 NM_016206 VGLL3 Hs00275109_s1 NM_016206 VGLL3 Hs00275109_s1 NM_003380 VIM Hs00958116_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_016303 WBP5 Hs02378843_s1 NM_003387 WIPF1 Hs01076141_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003881 WISP2 Hs00180242_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_003391 WNT2 Hs00608224_m1 NM_015472 WWTR1 Hs00210007_m1 NM_006106 YAP1 Hs00371735_m1 NM_015642 ZBTB20 Hs00210321_m1 NM_015642 ZBTB20 Hs00210321_m1 NM_145166 ZBTB47 Hs00908860_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_030751 ZEB1 Hs01566407_m1 U12170 ZEB1 Hs01566407_m1 NM_014795 ZEB2 Hs00207691_m1 NM_014795 ZEB2 Hs00207691_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_024721 ZFHX4 Hs00257312_s1 NM_004926 ZFP36L1 Hs00245183_m1 NM_006887 ZFP36L2 Hs00272828_m1 NM_012082 ZFPM2 Hs00201397_m1 NM_022470 ZMAT3 Hs00223860_m1 NM_015069 ZNF423 Hs00323880_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 NM_018181 ZNF532 Hs00539543_m1 EEF2 Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_013265 C11orf2 Hs00203146_m1 NM_001280 CIRBP Hs00989762_g1 NM_001280 CIRBP Hs00989762_g1 NM_001402 EEF1A1 Hs00265885_g1 NM_001404 EEF1G Hs01922638_u1 213 NM_001404 EEF1G Hs01922638_u1 NM_001961 EEF2 Hs01012839_g1 NM_003754 EIF3F Hs04187475_g1 BC000733 EIF3G Hs00186772_m1 NM_016091 EIF3L Hs01066348_g1 NM_001417 EIF4B Hs00251278_s1 NM_001417 EIF4B Hs00251278_s1 NM_015710 GLTSCR2 Hs00414236_m1 NM_015710 GLTSCR2 Hs00414236_m1 NM_002067 GNA11 Hs01588833_m1 NM_002067 GNA11 Hs01588833_m1 NM_002067 GNA11 Hs01588833_m1 NM_002067 GNA11 Hs01588833_m1 NM_006098 GNB2L1 Hs00914568_g1 BC000120 GTF2F1 Hs00157845_m1 NM_002136 HNRNPA1 Hs01656228_s1 NM_001551 IGBP1 Hs00426831_mH NM_000884 IMPDH2 Hs01021353_m1 NM_017572 MKNK2 Hs00179671_m1 NM_017572 MKNK2 Hs00179671_m1 NM_005594 NACA Hs01903640_uH NM_015897 PIAS4 Hs00185538_m1 NM_005051 QARS Hs00192530_m1 NM_006013 RPL10 Hs00749196_s1 NM_007104 RPL10A Hs01912344_uH NM_000975 RPL11 Hs00831112_s1 NM_000976 RPL12 Hs02385039_g1 NM_000976 RPL12 Hs02385039_g1 NM_000976 RPL12 Hs02385039_g1 NM_012423 RPL13A Hs01926559_g1 BC001675 RPL13A Hs03043885_g1 NM_012423 RPL13A Hs01926559_g1 BC000514 RPL13A Hs01926559_g1 NM_001034996 RPL14 Hs03004339_g1 U16738 RPL14 Hs03004339_g1 AF279903 RPL15 Hs00705011_s1 NM_000979 RPL18 Hs00965812_g1 NM_000983 RPL22 Hs01865331_s1 NM_000983 RPL22 Hs01865331_s1 NM_000992 RPL29 Hs00988959_gH NM_000992 RPL29 Hs00988959_gH NM_000992 RPL29 Hs00988959_gH NM_000967 RPL3 Hs01581771_g1 BC006483 RPL3 Hs01581771_g1 NM_000967 RPL3 Hs01581771_g1 214 NM_000967 RPL3 Hs01581771_g1 NM_015414 RPL36 Hs00762481_s1 NM_021029 RPL36A Hs00979517_g1 NM_000997 RPL37 Hs02340038_g1 NM_000997 RPL37 Hs02340038_g1 BC005817 RPL4 Hs01939407_gH NM_000968 RPL4 Hs01939407_gH NM_000968 RPL4 Hs01939407_gH NM_000969 RPL5 Hs03044958_g1 NM_000969 RPL5 Hs03044958_g1 NM_000972 RPL7A Hs02598230_gH NM_000972 RPL7A Hs02598230_gH NM_000972 RPL7A Hs02598230_gH NM_001004 RPLP2 Hs01115130_g1 NM_001018 RPS15 Hs01358643_g1 BC000354 RPS28 Hs02597258_g1 NM_001010 RPS6 Hs02339423_g1 NM_001010 RPS6 Hs02339423_g1 NM_001012 RPS8 Hs01374307_g1 NM_001013 RPS9 Hs02339426_g1 NM_001013 RPS9 Hs02339426_g1 AF272894 UBXN6 Hs00228853_m1 NM_025241 UBXN6 Hs00228853_m1 EIF2A Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') U49844 ATR Hs00354807_m1 NM_018195 C11orf57 Hs00217019_m1 BC006475 C3orf26 Hs00260635_m1 NM_005760 CEBPZ Hs00172900_m1 NM_025180 CEP63 Hs00375588_m1 NM_025180 CEP63 Hs00375588_m1 AF289495 CEP70 Hs00225806_m1 NM_016094 COMMD2 Hs00289862_s1 NM_004236 COPS2 Hs00182826_m1 NM_016302 CRBN Hs00372271_m1 NM_001007553 CSDE1 Hs00200261_m1 NM_020943 CWC22 Hs00326271_m1 AF106019 DDX20 Hs00200516_m1 AF334103 DDX50 Hs00430621_m1 AF217190 DHX36 Hs00325797_m1 NM_014953 DIS3 Hs00209014_m1 NM_006360 EIF3M Hs00272235_m1 NM_006360 EIF3M Hs00272235_m1 215 NM_001013438 FXR1 Hs01096876_g1 NM_005087 FXR1 Hs00245382_m1 NM_001011537 FYTTD1 Hs00260265_m1 NM_024996 GFM1 Hs00227997_m1 NM_024996 GFM1 Hs00227997_m1 NM_024996 GFM1 Hs00227997_m1 NM_024996 GFM1 Hs00227997_m1 NM_002128 HMGB1 Hs01923466_g1 NM_020800 IFT80 Hs00398803_m1 D84223 LARS Hs00219931_m1 NM_020117 LARS Hs00219931_m1 NM_181705 LYRM7 Hs00738930_m1 NM_020347 LZTFL1 Hs00220450_m1 NM_032390 MKI67IP Hs00757500_s1 AF212225 MRPL1 Hs00220322_m1 BC003375 MRPL3 Hs00246665_m1 NM_020191 MRPS22 Hs00220182_m1 NM_020191 MRPS22 Hs00220182_m1 NM_020191 MRPS22 Hs00220182_m1 NM_002453 MTIF2 Hs00267268_m1 NM_012123 MTO1 Hs00201667_m1 NM_025146 NAA50 Hs00363889_m1 NM_002492 NDUFB5 Hs00159582_m1 NM_015938 NMD3 Hs00274893_m1 NM_015938 NMD3 Hs00274893_m1 NM_015938 NMD3 Hs00274893_m1 AB042278 NPM1 Hs01576587_g1 NM_024947 PHC3 Hs00227887_m1 NM_002669 PLRG1 Hs00182215_m1 AB041261 PNPLA8 Hs00382272_m1 NM_020320 RARS2 Hs00368084_m1 NM_015014 RBM34 Hs00380698_m1 AF226052 RG9MTD1 Hs00215145_m1 NM_007282 RNF13 Hs00961507_m1 NM_032194 RPF2 Hs00828160_m1 NM_000986 RPL24 Hs02338570_gH NM_000986 RPL24 Hs02338570_gH NM_000996 RPL35A Hs02596935_g1 NM_000969 RPL5 Hs03044958_g1 NM_001010 RPS6 Hs02339423_g1 NM_015659 RSL1D1 Hs00378363_g1 NM_016304 RSL24D1 Hs00829770_g1 AF165521 RSL24D1 Hs00829770_g1 AL136807 SERP1 Hs00288000_s1 NM_020463 SMEK2 Hs00383278_m1 216 NM_007107 SSR3 Hs00606481_m1 NM_005862 STAG1 Hs00195307_m1 NM_018309 TBC1D23 Hs00217743_m1 NM_024818 UBA5 Hs01566989_m1 NM_001001992 USP16 Hs00170791_m1 NM_016485 VTA1 Hs00212881_m1 NM_021964 ZNF148 Hs00222661_m1 NM_021994 ZNF277 Hs00222737_m1 NM_152289 ZNF561 Hs00600950_m1 BC006279 ZNF627 Hs00377160_g1 FMOD Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') AF284095 ADRA2A Hs00265081_s1 NM_018071 ARHGEF40 Hs00216283_m1 NM_017787 C10orf26 Hs00740771_s1 NM_015463 CNRIP1 Hs00384403_m1 NM_021110 COL14A1 Hs00385388_m1 NM_001856 COL16A1 Hs00156876_m1 NM_052854 CREB3L1 Hs00999635_m1 NM_021198 CTDSP1 Hs00221852_m1 U20350 CX3CR1 Hs01922583_s1 NM_024843 CYBRD1 Hs00227411_m1 AL136693 CYBRD1 Hs00227411_m1 NM_001343 DAB2 Hs01120074_m1 NM_145056 DACT3 Hs00376818_m1 AF138303 DCN Hs00266491_m1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_001920 DCN Hs00754870_s1 NM_033425 DIXDC1 Hs00736707_m1 NM_001018057 DKK3 Hs00247429_m1 NM_001393 ECM2 Hs00154821_m1 AB030655 EFEMP2 Hs00213545_m1 NM_016938 EFEMP2 Hs00213545_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001996 FBLN1 Hs00242546_m1 NM_013231 FLRT2 Hs00544171_s1 NM_001012505 FOXP1 Hs00415004_m1 NM_001012505 FOXP1 Hs00415004_m1 NM_000148 FUT1 Hs00355741_m1 NM_031302 GLT8D2 Hs00229917_m1 217 NM_018841 GNG12 Hs03005750_m1 NM_000177 GSN Hs00388617_m1 NM_002775 HTRA1 Hs01016151_m1 NM_001007139 IGF2 Hs00277496_s1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_130469 JDP2 Hs00185689_m1 NM_015493 KANK2 Hs00795260_m1 NM_004235 KLF4 Hs00358836_m1 NM_004235 KLF4 Hs00358836_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002292 LAMB2 Hs00158642_m1 NM_005780 LHFP Hs00172961_m1 NM_005576 LOXL1 Hs00935937_m1 NM_001401 LPAR1 Hs00173500_m1 NM_002332 LRP1 Hs00233899_m1 NM_002404 MFAP4 Hs00412974_m1 NM_004530 MMP2 Hs00234422_m1 NM_145015 MRGPRF Hs01936726_s1 NM_001031679 MSRB3 Hs00827017_m1 U35139 NDN Hs00267349_s1 AF278532 NTN4 Hs00221915_m1 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_020190 OLFML3 Hs00220180_m1 NM_018222 PARVA Hs00217177_m1 NM_006207 PDGFRL Hs00185122_m1 NM_021630 PDLIM2 Hs00222154_m1 NM_003687 PDLIM4 Hs00184792_m1 BC003096 PDLIM4 Hs00184792_m1 NM_015009 PDZRN3 Hs00392900_m1 NM_174933 PHYHD1 Hs00288878_m1 NM_001007267 PLA2R1 Hs00234853_m1 NM_020353 PLSCR4 Hs00924823_m1 NM_020182 PMEPA1 Hs03987603_g1 L03203 PMP22 Hs00165556_m1 NM_153703 PODN Hs00542259_m1 NM_198859 PRICKLE2 Hs00291033_s1 NM_012232 PTRF Hs00396859_m1 NM_021111 RECK Hs01019179_m1 NM_004349 RUNX1T1 Hs00231702_m1 AF311912 SFRP2 Hs00293258_m1 218 NM_003013 SFRP2 Hs00293258_m1 NM_001009555 SH3D19 Hs00296942_m1 NM_003062 SLIT3 Hs00171524_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_005086 SSPN Hs00296706_s1 NM_015319 TENC1 Hs00539247_m1 BC001830 TGFB1I1 Hs00210887_m1 J03241 TGFB3 Hs01086000_m1 NM_024600 TMEM204 Hs01061927_m1 NM_022648 TNS1 Hs00917032_m1 BC000389 TSPAN4 Hs01587032_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_006887 ZFP36L2 Hs00272828_m1 NM_015069 ZNF423 Hs00323880_m1 COLGALT1 Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_031946 AGAP3 Hs00230596_m1 NM_024595 AKIRIN1 Hs00607590_m1 BC000764 AKIRIN2 Hs00363236_m1 NM_018064 AKIRIN2 Hs00363236_m1 NM_000692 ALDH1B1 Hs00377718_m1 AF274753 ANKH Hs00219798_m1 AF290613 AP1M1 Hs00261227_m1 NM_001024226 ARF1 Hs00761273_s1 M57763 ARF6 Hs00761810_s1 NM_004308 ARHGAP1 Hs00188815_m1 NM_005718 ARPC4 Hs00194811_m1 AF019888 ARPC4 Hs00194811_m1 NM_174983 C19orf28 Hs00545503_m1 NM_024033 C7orf49 Hs00256907_m1 NM_004343 CALR Hs00189032_m1 NM_001219 CALU Hs00154230_m1 NM_001219 CALU Hs00154230_m1 U67280 CALU Hs00154230_m1 AF294326 CBFB Hs00242386_m1 NM_138442 CCDC124 Hs00294009_m1 AB012305 CDK2 Hs01548894_m1 NM_013943 CLIC4 Hs00749895_s1 NM_001848 COL6A1 Hs00242448_m1 219 NM_007263 COPE Hs00200674_m1 BC002342 CORO1C Hs00170938_m1 NM_001908 CTSB Hs00947439_m1 NM_001814 CTSC Hs00175188_m1 NM_139179 DAGLB Hs00373700_m1 NM_001348 DAPK3 Hs00154676_m1 NM_024050 DDA1 Hs00610984_m1 D29643 DDOST Hs00193263_m1 NM_001375 DNASE2 Hs00923081_m1 NM_139265 EHD4 Hs00248124_m1 NM_001419 ELAVL1 Hs00171309_m1 AF177377 EML4 Hs00219420_m1 NM_001428 ENO1 Hs00361415_m1 NM_007051 FAF1 Hs00169544_m1 NM_004461 FARSA Hs00189494_m1 BC005147 FKBP1A Hs00356621_g1 NM_004514 FOXK2 Hs00536139_s1 NM_024955 FOXRED2 Hs00227920_m1 NM_002030 FPR3 Hs00266666_s1 NM_012280 FTSJ1 Hs00202185_m1 D13988 GDI2 Hs00357525_m1 NM_022343 GLIPR2 Hs00223508_m1 NM_024656 GLT25D1 Hs00430697_g1 M76477 GM2A Hs00166197_m1 NM_000405 GM2A Hs00166197_m1 NM_000405 GM2A Hs00166197_m1 NM_002074 GNB1 Hs00181845_m1 BC000873 GNB4 Hs01118085_m1 NM_004838 HOMER3 Hs00191446_m1 NM_005526 HSF1 Hs00232134_m1 NM_018992 KCTD5 Hs00368026_m1 NM_006854 KDELR2 Hs00199277_m1 U93240 KPNA4 Hs00601211_m1 NM_006762 LAPTM5 Hs00198882_m1 NM_032737 LMNB2 Hs00383326_m1 NM_012321 LSM4 Hs00202406_m1 NM_002745 MAPK1 Hs01052196_m1 AF100544 MAPK14 Hs00176248_m1 M64240 MAX Hs00231142_m1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_130807 MOBKL2A Hs00370031_m1 BC000756 MRPL4 Hs00211043_m1 NM_023018 NADK Hs00224899_m1 NM_014286 NCS1 Hs00179522_m1 220 BC003129 NONO Hs00939763_g1 NM_005234 NR2F6 Hs00172870_m1 AF022859 NRP2 Hs00187290_m1 NM_012346 NUP62 Hs02621445_s1 NM_152716 PATL1 Hs00405584_m1 NM_152716 PATL1 Hs00405584_m1 BC006344 PDIA4 Hs01115905_m1 NM_005742 PDIA6 Hs01012536_m1 BC001312 PDIA6 Hs01012536_m1 NM_005742 PDIA6 Hs01012536_m1 NM_005022 PFN1 Hs00748915_s1 NM_001008660 PICALM Hs00999731_g1 NM_001008660 PICALM Hs00999731_g1 AF230409 PML Hs00971694_m1 M32221 PSAP Hs01551088_g1 NM_002819 PTBP1 Hs00243060_m1 NM_006861 RAB35 Hs00199284_m1 NM_002882 RANBP1 Hs01597912_g1 NM_002886 RAP2B Hs00267932_s1 M62399 RELA Hs01042010_m1 NM_024832 RIN3 Hs00227365_m1 AF346602 SEC61A1 Hs01037684_m1 BC000154 SLC12A9 Hs01546995_m1 NM_005660 SLC35A2 Hs00194644_m1 BC003163 SLC43A3 Hs01061206_m1 AB026256 SLCO2B1 Hs00200670_m1 NM_020429 SMURF1 Hs00410929_m1 NM_003144 SSR1 Hs00162340_m1 NM_006927 ST3GAL2 Hs00199480_m1 NM_005419 STAT2 Hs01013126_g1 NM_006819 STIP1 Hs00428979_m1 NM_006936 SUMO3 Hs00739248_m1 NM_033161 SURF4 Hs00369130_m1 AF078866 SURF4 Hs00369130_m1 NM_007111 TFDP1 Hs00955491_gH NM_005782 THOC4 Hs00362329_m1 NM_005782 THOC4 Hs00362329_m1 NM_018475 TMEM165 Hs00218461_m1 NM_020243 TOMM22 Hs00560379_g1 NM_003290 TPM4 Hs01861627_g1 NM_025250 TTYH3 Hs00394292_m1 NM_006082 TUBA1B Hs00744842_sH BC004949 TUBA1C Hs00733770_m1 BC005946 TUBA1C Hs00733770_m1 BC005838 TUBB Hs00763510_gH 221 AF141349 TUBB Hs00763510_gH NM_030930 UNC93B1 Hs00276771_m1 U59323 UPF1 Hs00973118_g1 BC002411 YBX1 Hs00829347_g1 NM_004559 YBX1 Hs00829347_g1 NM_006555 YKT6 Hs00559914_m1 NM_003405 YWHAH Hs00607046_m1 U28964 YWHAZ Hs01122447_g1 NM_015457 ZDHHC5 Hs00379814_m1 HSP90AB1 Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_005692 ABCF2 Hs00255026_m1 U18197 ACLY Hs00982738_m1 NM_004208 AIFM1 Hs00377585_m1 NM_016237 ANAPC5 Hs01102438_m1 NM_017747 ANKHD1 Hs00368160_m1 NM_006305 ANP32A Hs00829953_g1 NM_001024226 ARF1 Hs00761273_s1 AF084520 ARFGEF1 Hs00963238_m1 NM_006421 ARFGEF1 Hs00963238_m1 NM_001025593 ARFIP1 Hs01029094_m1 NM_018120 ARMC1 Hs00603799_m1 NM_001686 ATP5B Hs00969569_m1 NM_005765 ATP6AP2 Hs00997145_m1 NM_001690 ATP6V1A Hs00156003_m1 NM_001695 ATP6V1C1 Hs00940702_m1 NM_015878 AZIN1 Hs00210634_m1 NM_001191 BCL2L1 Hs00169141_m1 NM_001191 BCL2L1 Hs00169141_m1 NM_014670 BZW1 Hs00602250_m1 NM_014145 C20orf30 Hs00793426_m1 NM_006443 C6orf108 Hs00197576_m1 NM_030939 C6orf62 Hs00229553_m1 NM_030939 C6orf62 Hs00229553_m1 NM_032120 C7orf64 Hs00603900_g1 NM_023080 C8orf33 Hs00535769_m1 AF151824 CAB39 Hs00212451_m1 L18887 CANX Hs01558409_m1 NM_001024649 CANX Hs01558409_m1 NM_014296 CAPN7 Hs00204734_m1 NM_005898 CAPRIN1 Hs01075318_m1 NM_005898 CAPRIN1 Hs01075318_m1 NM_001014437 CARS Hs01000965_m1 222 NM_006431 CCT2 Hs00197562_m1 NM_006430 CCT4 Hs00272345_m1 NM_001253 CDC5L Hs00154370_m1 L08599 CDH1 Hs01013958_m1 NM_004779 CNOT8 Hs00231841_m1 NM_004371 COPA Hs00189232_m1 NM_006710 COPS8 Hs00991301_g1 NM_001895 CSNK2A1 Hs00751002_s1 BC000021 CYB561 Hs00157220_m1 NM_014764 DAZAP2 Hs00429643_m1 NM_001012732 DCTD Hs01126095_m1 AF061337 DDX3X Hs00606179_m1 NM_003677 DENR Hs00795562_s1 AF279891 DHX15 Hs00154713_m1 NM_001357 DHX9 Hs00357476_m1 U59151 DKC1 Hs00154737_m1 NM_001539 DNAJA1 Hs00266011_m1 NM_006145 DNAJB1 Hs00428680_m1 NM_052951 DNTTIP1 Hs00369479_m1 NM_001011546 DSTN Hs00800683_s1 NM_001968 EIF4E Hs00854166_g1 NM_001969 EIF5 Hs01028811_g1 NM_001428 ENO1 Hs00361415_m1 NM_004436 ENSA Hs00705265_s1 NM_017697 ESRP1 Hs00214472_m1 NM_006544 EXOC5 Hs00272473_m1 NM_014285 EXOSC2 Hs00204705_m1 NM_019037 EXOSC4 Hs00363401_g1 NM_003379 EZR Hs00931646_m1 NM_003379 EZR Hs00931646_m1 NM_003379 EZR Hs00931646_m1 NM_004461 FARSA Hs00189494_m1 NM_002014 FKBP4 Hs00427038_g1 NM_005803 FLOT1 Hs00195134_m1 NM_007085 FSTL1 Hs00907496_m1 NM_001011537 FYTTD1 Hs00260265_m1 NM_006836 GCN1L1 Hs00412445_m1 D13988 GDI2 Hs00357525_m1 NM_024996 GFM1 Hs00227997_m1 NM_032380 GFM2 Hs00260735_m1 NM_015044 GGA2 Hs00209277_m1 BC000284 GGA2 Hs00209277_m1 NM_006708 GLO1 Hs00198702_m1 AF118652 GLRX3 Hs01582641_g1 NM_012084 GLUD2 Hs00273224_s1 223 NM_002076 GNS Hs00157741_m1 NM_002094 GSPT1 Hs01093019_m1 BC004472 GTF2I Hs00263393_m1 NM_005324 H3F3B Hs00287906_s1 NM_004500 HNRNPC Hs01028910_g1 NM_004966 HNRNPF Hs00359014_m1 AF028832 HSP90AA1 Hs00743767_sH NM_001017963 HSP90AA1 Hs00743767_sH AF275719 HSP90AB1 Hs00607336_gH NM_003299 HSP90B1 Hs00427665_g1 BC002526 HSPA4 Hs00382884_m1 AF352832 HSPA8 Hs00852842_gH BC000478 HSPA9 Hs00269818_m1 NM_004134 HSPA9 Hs00269818_m1 NM_002156 HSPD1 Hs01866140_g1 NM_002156 HSPD1 Hs01866140_g1 NM_005530 IDH3A Hs00194253_m1 NM_004515 ILF2 Hs01080165_g1 NM_016338 IPO11 Hs00275241_m1 AF151086 KBTBD4 Hs00560341_m1 NM_018992 KCTD5 Hs00368026_m1 NM_007317 KIF22 Hs00173253_m1 NM_021633 KLHL12 Hs00603108_mH U93240 KPNA4 Hs00601211_m1 AF348513 LMBR1 Hs00223794_m1 NM_012321 LSM4 Hs00202406_m1 NM_002355 M6PR Hs01124302_m1 NM_014628 MAD2L1BP Hs00206004_m1 AF100544 MAPK14 Hs00176248_m1 NM_012325 MAPRE1 Hs01121102_g1 NM_005911 MAT2A Hs00428515_g1 NM_018834 MATR3 Hs00251579_m1 M64240 MAX Hs00231142_m1 NM_003791 MBTPS1 Hs00186886_m1 NM_002388 MCM3 Hs00172459_m1 NM_014160 MKRN2 Hs00274055_m1 NM_014078 MRPL13 Hs01091048_m1 NM_032111 MRPL14 Hs00372862_m1 NM_022915 MRPL44 Hs00224773_m1 NM_018141 MRPS10 Hs00216720_m1 NM_021107 MRPS12 Hs00221633_m1 AB049952 MRPS18A Hs00606652_m1 BC005373 MRPS18B Hs00204096_m1 BC000242 MRPS23 Hs00608544_m1 D89646 MSH6 Hs00264721_m1 224 NM_003828 MTMR1 Hs00382245_m1 NM_025146 NAA50 Hs00363889_m1 NM_005899 NBR1 Hs00245918_m1 NM_004741 NOLC1 Hs00170493_m1 BC003129 NONO Hs00939763_g1 L14599 NONO Hs00939763_g1 AB042278 NPM1 Hs01576587_g1 NM_022731 NUCKS1 Hs01068059_g1 NM_018230 NUP133 Hs00217272_m1 NM_004152 OAZ1 Hs00427923_m1 AF242521 OAZ2 Hs00159726_m1 NM_017830 OCIAD1 Hs00215197_m1 NM_006452 PAICS Hs00272390_m1 BC001716 PAIP2 Hs00212868_m1 D25547 PCMT1 Hs00193600_m1 NM_014891 PDAP1 Hs01634881_s1 NM_005742 PDIA6 Hs01012536_m1 NM_000291 PGK1 Hs00943178_g1 NM_000291 PGK1 Hs00943178_g1 NM_024613 PLEKHF2 Hs01890213_s1 NM_020143 PNO1 Hs00220044_m1 NM_002695 POLR2E Hs00267554_m1 NM_017739 POMGNT1 Hs00214729_m1 NM_005038 PPID Hs00234593_m1 AB000635 PPP2R5D Hs00605059_m1 NM_006247 PPP5C Hs00196577_m1 NM_001032381 PQBP1 Hs00172888_m1 NM_000947 PRIM2 Hs00168726_m1 NM_002734 PRKAR1A Hs00267597_m1 M18468 PRKAR1A Hs00267597_m1 U34994 PRKDC Hs00179161_m1 NM_006109 PRMT5 Hs01047356_m1 NM_015629 PRPF31 Hs00210306_m1 NM_002787 PSMA2 Hs00746751_s1 NM_002804 PSMC3 Hs00267682_m1 NM_002812 PSMD8 Hs00601309_m1 BC002684 PSME3 Hs00195072_m1 NM_005789 PSME3 Hs00195072_m1 NM_002819 PTBP1 Hs00243060_m1 BC003005 PTGES3 Hs00832847_gH NM_005607 PTK2 Hs01056457_m1 NM_016395 PTPLAD1 Hs00179633_m1 NM_021252 RAB18 Hs00222021_m1 NM_004161 RAB1A Hs00800204_s1 NM_004162 RAB5A Hs00702360_s1 225 NM_006265 RAD21 Hs00366726_m1 AF054183 RAN Hs00741099_g1 NM_005493 RANBP9 Hs01116140_m1 NM_005493 RANBP9 Hs01116140_m1 NM_002883 RANGAP1 Hs00610049_m1 NM_005610 RBBP4 Hs01568507_g1 NM_018047 RBM22 Hs00216159_m1 NM_018835 RC3H2 Hs00218941_m1 NM_004290 RNF14 Hs00366339_m1 NM_001033 RRM1 Hs01040698_m1 NM_004866 SCAMP1 Hs00792736_m1 NM_003001 SDHC Hs01698067_s1 NM_006363 SEC23B Hs00197211_m1 AF346602 SEC61A1 Hs01037684_m1 NM_016275 SELT Hs00892526_g1 NM_015640 SERBP1 Hs00854675_gH NM_003011 SET Hs00853870_g1 NM_006930 SKP1 Hs00749532_s1 NM_001152 SLC25A5 Hs00854499_g1 AF079117 SLC29A1 Hs01085706_m1 NM_005660 SLC35A2 Hs00194644_m1 NM_016045 SLMO2 Hs00429845_m1 NM_003072 SMARCA4 Hs00231324_m1 NM_003074 SMARCC1 Hs02559508_s1 NM_003825 SNAP23 Hs00187075_m1 NM_006415 SPTLC1 Hs00272311_m1 NM_003129 SQLE Hs01123768_m1 NM_006947 SRP72 Hs00601540_m1 NM_182691 SRPK2 Hs00795102_m1 NM_015908 SRRT Hs01056389_g1 NM_006924 SRSF1 Hs00199471_m1 AF047448 SRSF10 Hs00793055_g1 NM_003016 SRSF2 Hs01923929_s1 NM_003017 SRSF3 Hs00751507_s1 NM_001007559 SS18 Hs01075912_m1 NM_003146 SSRP1 Hs00172629_m1 NM_003932 ST13 Hs00832556_sH NM_006819 STIP1 Hs00428979_m1 U67122 SUMO1 Hs00830844_g1 NM_007192 SUPT16H Hs00200446_m1 BC004439 TIMM17A Hs00197081_m1 NM_006327 TIMM23 Hs00197056_m1 NM_014742 TM9SF4 Hs00207196_m1 AF033095 TMBIM6 Hs00162661_m1 NM_006815 TMED2 Hs00607277_m1 226 NM_006815 TMED2 Hs00607277_m1 NM_030969 TMEM14B Hs00852500_g1 NM_152464 TMEM199 Hs00382320_m1 NM_016456 TMEM9 Hs00212825_m1 NM_030755 TMX1 Hs00702835_s1 NM_001025252 TPD52 Hs00896046_m1 NM_001025252 TPD52 Hs00896046_m1 BC000451 TRA2B Hs00907493_m1 NM_014294 TRAM1 Hs01116824_m1 AF230394 TRIM27 Hs00179059_m1 NM_003496 TRRAP Hs01591130_m1 NM_004622 TSN Hs00172824_m1 NM_018128 TSR1 Hs00911303_g1 M26880 UBC Hs01871556_s1 NM_003340 UBE2D3 Hs00701790_s1 NM_003348 UBE2N Hs00854751_s1 NM_006048 UBE4B Hs00195897_m1 AF006010 UBR5 Hs00210750_m1 NM_014607 UBXN4 Hs00908410_m1 NM_003366 UQCRC2 Hs00996395_m1 NM_032334 UTP23 Hs00260536_m1 BC005941 VAMP3 Hs00922166_m1 NM_004781 VAMP3 Hs00922166_m1 NM_003374 VDAC1 Hs01631624_gH NM_003374 VDAC1 Hs01631624_gH NM_018206 VPS35 Hs00372497_m1 AF309553 WDR61 Hs00228800_m1 AF298880 XPO5 Hs00382453_m1 NM_020750 XPO5 Hs00382453_m1 BC000129 XPO5 Hs00382453_m1 AL136841 XRN2 Hs00560009_m1 NM_012255 XRN2 Hs00560009_m1 NM_030799 YIPF5 Hs01093311_m1 U28936 YWHAE Hs00356749_g1 NM_003406 YWHAZ Hs00852925_sH BC003623 YWHAZ Hs00852925_sH U28964 YWHAZ Hs01122447_g1 HSPB6 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_080284 ABCA6 Hs00365329_m1 NM_007168 ABCA8 Hs00992371_m1 NM_080283 ABCA9 Hs00329320_m1 AB056106 ABI3BP Hs00248821_m1 227 NM_001093 ACACB Hs01565927_g1 NM_001093 ACACB Hs01565927_g1 NM_001093 ACACB Hs01565927_g1 NM_017888 ACSM5 Hs00384980_m1 NM_000020 ACVRL1 Hs00163543_m1 NM_025220 ADAM33 Hs00296426_m1 NM_139247 ADCY4 Hs00328499_m1 NM_001118 ADCYAP1R1 Hs00153869_m1 NM_000667 ADH1A Hs00605167_g1 AF153821 ADH1B Hs00605175_m1 M24317 ADH1B Hs00605175_m1 M21692 ADH1B Hs00605175_m1 NM_000669 ADH1C Hs00817827_m1 NM_004797 ADIPOQ Hs02564413_s1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 NM_001353 AKR1C1 Hs04230636_sH NM_001353 AKR1C1 Hs04230636_sH U05598 AKR1C2 Hs00413886_m1 AB015228 ALDH1A2 Hs00180254_m1 NM_012190 ALDH1L1 Hs00201836_m1 NM_004673 ANGPTL1 Hs00559786_m1 AB056476 ANGPTL1 Hs00559786_m1 NM_004673 ANGPTL1 Hs00559786_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_001148 ANK2 Hs00153998_m1 NM_003734 AOC3 Hs00186647_m1 NM_005161 APLNR Hs00270873_s1 NM_001170 AQP7 Hs00357359_m1 NM_173800 AQPEP Hs00545100_m1 NM_022481 ARAP3 Hs00223903_m1 NM_020809 ARHGAP20 Hs00826991_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_000049 ASPA Hs00163703_m1 NM_032827 ATOH8 Hs00262454_m1 NM_001003696 ATP5J Hs01081389_g1 NM_017614 BHMT2 Hs00214120_m1 NM_017614 BHMT2 Hs00214120_m1 NM_033254 BOC Hs00264408_m1 AY027658 BOC Hs00264408_m1 NM_152547 BTNL9 Hs00537320_m1 NM_152547 BTNL9 Hs00537320_m1 NM_007021 C10orf10 Hs00199735_m1 AL136653 C10orf10 Hs00199735_m1 228 NM_032849 C13orf33 Hs00262558_m1 NM_030968 C1QTNF1 Hs00945123_m1 NM_001733 C1R Hs00354278_m1 NM_080625 C20orf160 Hs00381168_m1 AF325503 C2orf40 Hs00260897_m1 J05064 C6 Hs01110040_m1 NM_000587 C7 Hs00175109_m1 NM_024913 C7orf58 Hs00227735_m1 NM_000717 CA4 Hs00426343_m1 NM_000717 CA4 Hs00426343_m1 NM_001232 CASQ2 Hs00154286_m1 NM_001753 CAV1 Hs00971716_m1 NM_001753 CAV1 Hs00971716_m1 NM_001233 CAV2 Hs00184597_m1 NM_001233 CAV2 Hs00184597_m1 AL136562 CCDC3 Hs00230222_m1 NM_015621 CCDC69 Hs00248958_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_020404 CD248 Hs00535586_s1 M81104 CD34 Hs00990735_m1 M98399 CD36 Hs01567186_m1 NM_000072 CD36 Hs01567186_m1 NM_000072 CD36 Hs01567186_m1 NM_001795 CDH5 Hs00901463_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_001801 CDO1 Hs00156447_m1 S73751 CES1 Hs00275607_m1 NM_001928 CFD Hs00157263_m1 NM_003956 CH25H Hs02379634_s1 NM_145234 CHRDL1 Hs00292767_m1 NM_001279 CIDEA Hs00154455_m1 NM_022094 CIDEC Hs00535723_m1 NM_003277 CLDN5 Hs00533949_s1 NM_175060 CLEC14A Hs00545534_s1 NM_003278 CLEC3B Hs00162844_m1 NM_001299 CNN1 Hs00154543_m1 NM_015463 CNRIP1 Hs00384403_m1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 NM_006091 CORO2B Hs00379744_m1 229 AF007162 CRYAB Hs00157107_m1 NM_024689 CXorf36 Hs00226702_m1 NM_024689 CXorf36 Hs00226702_m1 NM_000398 CYB5R3 Hs00240921_m1 NM_134268 CYGB Hs00370478_m1 NM_052954 CYYR1 Hs00364793_m1 NM_002036 DARC Hs01011079_s1 NM_001014796 DDR2 Hs01025953_m1 NM_006182 DDR2 Hs01025953_m1 NM_032564 DGAT2 Hs01045913_m1 AB048286 DGAT2 Hs01045913_m1 AF284225 DMRT2 Hs00246364_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_022659 EBF2 Hs00224081_m1 NM_001005463 EBF3 Hs00291943_s1 NM_001005463 EBF3 Hs00291943_s1 NM_001964 EGR1 Hs00152928_m1 NM_001964 EGR1 Hs00152928_m1 NM_000399 EGR2 Hs00166165_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_000501 ELN Hs01091772_m1 NM_022159 ELTD1 Hs03987598_m1 NM_016242 EMCN Hs01038209_m1 AF205940 EMCN Hs01038209_m1 NM_016242 EMCN Hs01038209_m1 NM_000118 ENG Hs03986114_s1 D45421 ENPP2 Hs00196470_m1 L35594 ENPP2 Hs00196470_m1 NM_001430 EPAS1 Hs01026142_m1 NM_004449 ERG Hs01554635_m1 NM_138961 ESAM Hs00332781_m1 NM_001442 FABP4 Hs01086178_g1 NM_001442 FABP4 Hs01086178_g1 AL050264 FAM107A Hs00200376_m1 NM_153690 FAM43A Hs00538124_s1 NM_198552 FAM89A Hs00293357_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 230 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 U29538 FHL1 Hs00793641_g1 AF098518 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 AF063002 FHL1 Hs00793641_g1 NM_004469 FIGF Hs00189521_m1 NM_013231 FLRT2 Hs00544171_s1 BC005894 FMO2 Hs00155158_m1 NM_001460 FMO2 Hs00155158_m1 NM_022823 FNDC4 Hs00224502_m1 NM_006732 FOSB Hs01547109_m1 NM_144966 FREM1 Hs00381549_m1 NM_005031 FXYD1 Hs00245327_m1 NM_012193 FZD4 Hs00201853_m1 NM_015714 G0S2 Hs00274783_s1 NM_004962 GDF10 Hs01086867_m1 NM_005261 GEM Hs00738924_m1 NM_004121 GGT5 Hs00269779_m1 NM_005838 GLYAT Hs00973654_m1 NM_004126 GNG11 Hs00914578_m1 NM_020918 GPAM Hs01573680_m1 NM_020918 GPAM Hs01573680_m1 NM_005276 GPD1 Hs00193386_m1 NM_005276 GPD1 Hs00193386_m1 NM_178172 GPIHBP1 Hs00417223_g1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_138445 GPR146 Hs00298904_s1 NM_002084 GPX3 Hs02513161_s1 NM_002084 GPX3 Hs02513161_s1 NM_000177 GSN Hs00388617_m1 U94363 GYG2 Hs00187459_m1 NM_003918 GYG2 Hs00187459_m1 NM_002101 GYPC Hs00242584_m1 NR_002196 H19 Hs00262142_g1 AF349571 HBA1 Hs00361191_g1 NM_000558 HBA1 Hs00361191_g1 BC005931 HBA1 Hs00361191_g1 AF105974 HBA1 Hs00361191_g1 NM_000517 HBA2 Hs00361191_g1 NM_000517 HBA2 Hs00361191_g1 NM_152722 HEPACAM Hs00404147_m1 NM_052970 HSPA12B Hs00369554_m1 231 NM_001541 HSPB2 Hs00155436_m1 NM_144617 HSPB6 Hs00328933_m1 NM_014424 HSPB7 Hs00205296_m1 M85289 HSPG2 Hs01078536_m1 M37484 IGF1 Hs01547657_m1 M29644 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_000612 IGF2 Hs00277496_s1 NM_001007139 IGF2 Hs00277496_s1 NM_002178 IGFBP6 Hs00942697_m1 NM_178822 IGSF10 Hs00975906_m1 AB024518 IL33 Hs00369211_m1 AF128846 INMT Hs00198941_m1 AF072132 ITGA7 Hs00174397_m1 NM_002206 ITGA7 Hs00174397_m1 NM_030569 ITIH5 Hs00262393_s1 NM_004867 ITM2A Hs01011360_g1 NM_004867 ITM2A Hs01011360_g1 AF114488 ITSN1 Hs00161676_m1 NM_001001132 ITSN1 Hs00161676_m1 NM_021219 JAM2 Hs01022013_m1 NM_002229 JUNB Hs01564117_s1 NM_015493 KANK2 Hs00795260_m1 NM_198471 KANK3 Hs00418312_m1 AL136722 KCNIP2 Hs01552688_g1 NM_175737 KLB Hs00545621_m1 NM_175737 KLB Hs00545621_m1 NM_014079 KLF15 Hs00362736_m1 NM_016270 KLF2 Hs00360439_g1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_001290 LDB2 Hs00609711_m1 NM_000230 LEP Hs00174877_m1 U50748 LEPR Hs00900242_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_014368 LHX6 Hs00232660_m1 NM_017980 LIMS2 Hs01002880_gH NM_005357 LIPE Hs00943410_m1 NM_005357 LIPE Hs00943410_m1 NM_012134 LMOD1 Hs00201704_m1 NM_000237 LPL Hs01012571_m1 NM_000237 LPL Hs01012571_m1 232 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_005512 LRRC32 Hs00194136_m1 NM_181506 LRRC70 Hs00704102_s1 NM_003573 LTBP4 Hs00186025_m1 NM_006691 LYVE1 Hs00272659_m1 NM_002373 MAP1A Hs00357973_m1 M28882 MCAM Hs00920938_g1 NM_006500 MCAM Hs00920938_g1 AF089868 MCAM Hs00920938_g1 NM_004527 MEOX1 Hs00244943_m1 NM_005924 MEOX2 Hs00232248_m1 NM_002404 MFAP4 Hs00412974_m1 NM_007287 MME Hs00153519_m1 U38321 MMP19 Hs00275699_m1 NM_024756 MMRN2 Hs00226971_m1 NM_024756 MMRN2 Hs00226971_m1 NM_145015 MRGPRF Hs01936726_s1 NM_205853 MUSTN1 Hs01592115_g1 NM_025107 MYCT1 Hs00228305_m1 NM_002474 MYH11 Hs00224610_m1 NM_022844 MYH11 Hs00224622_m1 NM_005467 NAALAD2 Hs01119919_m1 U35139 NDN Hs00267349_s1 NM_002507 NGFR Hs00182120_m1 NM_005386 NNAT Hs00704196_s1 NM_004557 NOTCH4 Hs00965895_g1 NM_000906 NPR1 Hs00181445_m1 NM_000906 NPR1 Hs00181445_m1 NM_016588 NRN1 Hs00213192_m1 NM_178507 OAF Hs00420156_m1 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_145260 OSR1 Hs00377071_m1 NM_002579 PALM Hs00608156_m1 NM_017734 PALMD Hs00214675_m1 NM_017734 PALMD Hs00214675_m1 NM_001001991 PAMR1 Hs00405837_m1 NM_019035 PCDH18 Hs00251855_m1 NM_002591 PCK1 Hs00159918_m1 NM_013363 PCOLCE2 Hs00203477_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_002599 PDE2A Hs01042255_m1 233 NM_000922 PDE3B Hs01057215_m1 NM_000922 PDE3B Hs01057215_m1 NM_002612 PDK4 Hs01037704_m1 NM_000442 PECAM1 Hs00169777_m1 NM_000442 PECAM1 Hs00169777_m1 NM_021965 PGM5 Hs00222671_m1 NM_015157 PHLDB1 Hs00384827_m1 NM_138370 PKDCC Hs00293125_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_002666 PLIN1 Hs01106927_m1 NM_006227 PLTP Hs00272126_m1 AF326591 PLVAP Hs00229941_m1 NM_020376 PNPLA2 Hs00386101_m1 NM_020376 PNPLA2 Hs00386101_m1 NM_153703 PODN Hs00542259_m1 AB000888 PPAP2A Hs00170356_m1 AF014403 PPAP2A Hs00170356_m1 NM_015869 PPARG Hs00234592_m1 NM_014634 PPM1F Hs00206069_m1 NM_033256 PPP1R14A Hs00264434_m1 NM_014330 PPP1R15A Hs00169585_m1 NM_014330 PPP1R15A Hs00169585_m1 NM_006741 PPP1R1A Hs00410058_m1 NM_002716 PPP2R1B Hs00988483_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_000313 PROS1 Hs00165590_m1 NM_000961 PTGIS Hs00919949_m1 NM_002837 PTPRB Hs01549049_m1 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 NM_005854 RAMP2 Hs00237194_m1 U78168 RAPGEF3 Hs00183449_m1 NM_017805 RASIP1 Hs00215089_m1 NM_016563 RASL12 Hs00275429_m1 NM_014483 RBMS3 Hs00205567_m1 NM_006744 RBP4 Hs00924047_m1 U43559 RDH5 Hs00161263_m1 AF186779 RGL1 Hs00248508_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 NM_019055 ROBO4 Hs00219408_m1 NM_004349 RUNX1T1 Hs00231702_m1 234 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001400 S1PR1 Hs01922614_s1 NM_000331 SAA1 Hs00761940_s1 NM_030754 SAA2 Hs00754237_s1 NM_173833 SCARA5 Hs01073151_m1 NM_173833 SCARA5 Hs01073151_m1 NM_174934 SCN4B Hs00545394_m1 NM_004657 SDPR Hs00190538_m1 NM_004657 SDPR Hs00190538_m1 NM_003005 SELP Hs00356351_m1 NM_020163 SEMA3G Hs00220101_m1 NM_000062 SERPING1 Hs00934330_m1 NM_005489 SH2D3C Hs01552509_m1 NM_004731 SLC16A7 Hs00940851_m1 NM_025243 SLC19A3 Hs00228858_m1 NM_025243 SLC19A3 Hs00228858_m1 NM_003062 SLIT3 Hs00171524_m1 AB011538 SLIT3 Hs00171524_m1 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 NM_003102 SOD3 Hs00162090_m1 NM_015385 SORBS1 Hs00908953_m1 NM_022454 SOX17 Hs00751752_s1 NM_018419 SOX18 Hs00746079_s1 NM_031439 SOX7 Hs00846731_s1 NM_005841 SPRY1 Hs01083036_s1 NM_005842 SPRY2 Hs01921749_s1 NM_003128 SPTBN1 Hs01555159_m1 NM_006307 SRPX Hs00196867_m1 NM_003178 SYN2 Hs00268427_m1 NM_007286 SYNPO Hs00702468_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_152380 TBX15 Hs00537087_m1 NM_000459 TEK Hs00945146_m1 NM_015319 TENC1 Hs00539247_m1 NM_001063 TF Hs01067777_m1 NM_001063 TF Hs01067777_m1 NM_003248 THBS4 Hs00170261_m1 NM_005424 TIE1 Hs00892696_m1 NM_003256 TIMP4 Hs00162784_m1 AB002318 TLN2 Hs00322257_m1 NM_018286 TMEM100 Hs00388033_m1 NM_183240 TMEM37 Hs01931464_s1 235 NM_022144 TNMD Hs00223332_m1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_173485 TSHZ2 Hs00251507_s1 NM_004615 TSPAN7 Hs00190284_m1 NM_172367 TUSC5 Hs00542659_m1 NM_057179 TWIST2 Hs00382379_m1 NM_000552 VWF Hs00169795_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_003407 ZFP36 Hs00185658_m1 NM_015069 ZNF423 Hs00323880_m1 LUM Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_001033583 ACOT9 Hs00202482_m1 NM_022977 ACSL4 Hs01547083_m1 NM_001613 ACTA2 Hs00426835_g1 NM_001102 ACTN1 Hs00998100_m1 NM_001105 ACVR1 Hs00153836_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_139056 ADAMTS16 Hs01049997_m1 NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_197941 ADAMTS6 Hs00812159_s1 NM_001114 ADCY7 Hs00936808_m1 NM_001129 AEBP1 Hs00937468_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_005465 AKT3 Hs00289302_s1 NM_005465 AKT3 Hs00289302_s1 236 NM_001034173 ALDH1L2 Hs00402876_m1 NM_052947 ALPK2 Hs00364763_m1 NM_130847 AMOTL1 Hs00294070_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_054027 ANKH Hs00219798_m1 NM_054027 ANKH Hs00219798_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_001025356 ANO6 Hs01374899_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_000700 ANXA1 Hs00945401_m1 NM_001153 ANXA4 Hs00984874_m1 NM_001025616 ARHGAP24 Hs01097580_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_005737 ARL4C Hs00255039_s1 AF316824 ASPN Hs00214395_m1 NM_017680 ASPN Hs00214395_m1 NM_020453 ATP10D Hs00935004_m1 NM_001003696 ATP5J Hs01081389_g1 NM_001003803 ATP5S Hs00210402_m1 NM_000332 ATXN1 Hs00165656_m1 NM_021913 AXL Hs01064444_m1 NM_012104 BACE1 Hs01123242_m1 NM_005504 BCAT1 Hs00298666_s1 NM_005504 BCAT1 Hs00298666_s1 NM_152731 BEND6 Hs00288163_m1 NM_001711 BGN Hs00959143_m1 NM_001711 BGN Hs00959143_m1 BC002416 BGN Hs00959143_m1 NM_152414 BHLHE22 Hs01084964_s1 NM_017614 BHMT2 Hs00214120_m1 NM_006129 BMP1 Hs00196183_m1 NM_001199 BMP1 Hs00986789_m1 NM_001204 BMPR2 Hs00176148_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 237 NM_014059 C13orf15 Hs00204129_m1 NM_030945 C1QTNF3 Hs00229569_m1 AF329841 C1QTNF5 Hs00363053_g1 AF329842 C1QTNF6 Hs00230464_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 NM_004772 C5orf13 Hs00854282_g1 AF313413 C5orf62 Hs00383944_m1 NM_024728 C7orf10 Hs00257329_m1 NM_024913 C7orf58 Hs00227735_m1 NM_032823 C9orf3 Hs01051467_m1 NM_000722 CACNA2D1 Hs00984856_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_001219 CALU Hs00154230_m1 AF356193 CARD6 Hs01123611_m1 NM_001753 CAV1 Hs00971716_m1 NM_001233 CAV2 Hs00184597_m1 NM_001233 CAV2 Hs00184597_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_001759 CCND2 Hs00922419_g1 NM_016557 CCRL1 Hs00664347_s1 AF063591 CD200 Hs01033303_m1 NM_020404 CD248 Hs00535586_s1 NM_000574 CD55 Hs00167090_m1 BC001288 CD55 Hs00167090_m1 NM_002414 CD99 Hs00365982_m1 U82164 CD99 Hs00242853_m1 NM_002414 CD99 Hs00365982_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_012395 CDK14 Hs00202633_m1 NM_003159 CDKL5 Hs00177340_m1 NM_004936 CDKN2B Hs00793225_m1 NM_006561 CELF2 Hs00990166_m1 NM_016174 CERCAM Hs00170969_m1 NM_000186 CFH Hs00962366_m1 238 NM_000186 CFH Hs00962366_m1 NM_018413 CHST11 Hs00218229_m1 NM_175856 CHSY3 Hs00545664_m1 NM_003613 CILP Hs00173647_m1 NM_016326 CKLF Hs00793072_m1 D86586 CLEC11A Hs00161544_m1 NM_002975 CLEC11A Hs00161544_m1 BC005810 CLEC11A Hs00161544_m1 BC005254 CLEC2B Hs00192860_m1 NM_013943 CLIC4 Hs00749895_s1 NM_024769 CLMP Hs00956750_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 NM_004368 CNN2 Hs00854264_s1 NM_152755 CNPY4 Hs00414977_m1 NM_015463 CNRIP1 Hs00384403_m1 U07820 CNTN1 Hs00169986_m1 NM_000493 COL10A1 Hs00166657_m1 NM_000493 COL10A1 Hs00166657_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_001854 COL11A1 Hs01097664_m1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_004370 COL12A1 Hs00329355_s1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 NM_001856 COL16A1 Hs00156876_m1 NM_030582 COL18A1 Hs01043425_g1 AF018081 COL18A1 Hs01043425_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 NM_000393 COL5A2 Hs00893923_m1 NM_015719 COL5A3 Hs00210526_m1 NM_015719 COL5A3 Hs00210526_m1 239 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 AY029208 COL6A2 Hs00242484_m1 NM_001849 COL6A2 Hs00242484_m1 NM_004369 COL6A3 Hs00915120_m1 NM_001850 COL8A1 Hs00156669_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_000095 COMP Hs00164359_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_001864 COX7A1 Hs00156989_m1 NM_001870 CPA3 Hs00157019_m1 NM_153634 CPNE8 Hs00402394_m1 NM_019609 CPXM1 Hs01566704_g1 BC006393 CPZ Hs00186333_m1 AL136861 CRISPLD2 Hs00230322_m1 NM_018590 CSGALNACT2 Hs00603821_m1 NM_018590 CSGALNACT2 Hs00603821_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_138455 CTHRC1 Hs00298917_m1 NM_000396 CTSK Hs00166156_m1 NM_000609 CXCL12 Hs00930455_m1 NM_020311 CXCR7 Hs00664172_s1 NM_000104 CYP1B1 Hs00164383_m1 NM_183075 CYP2U1 Hs00766273_m1 AF003114 CYR61 Hs00998503_g1 NM_001554 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 BC003064 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_173674 DCBLD1 Hs00920580_m1 NM_003737 DCHS1 Hs01044548_m1 NM_001920 DCN Hs00754870_s1 AF138303 DCN Hs00266491_m1 NM_001920 DCN Hs00754870_s1 240 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_006182 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_139160 DEPDC7 Hs00373609_m1 NM_004403 DFNA5 Hs00189346_m1 NM_000793 DIO2 Hs00255341_m1 NM_013989 DIO2 Hs00255341_m1 NM_014974 DIP2C Hs00324224_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 AF026219 DLC1 Hs00931487_m1 NM_006094 DLC1 Hs00183436_m1 NM_144658 DOCK11 Hs00376176_m1 NM_014705 DOCK4 Hs00206807_m1 M74777 DPP4 Hs00175210_m1 NM_001935 DPP4 Hs00175210_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_000110 DPYD Hs02510591_s1 NM_001387 DPYSL3 Hs00181665_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_013352 DSE Hs00203441_m1 NM_014934 DZIP1 Hs00208790_m1 NM_024007 EBF1 Hs00395513_m1 NM_001393 ECM2 Hs00154821_m1 NM_005711 EDIL3 Hs00174781_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_003566 EEA1 Hs00929215_m1 NM_016938 EFEMP2 Hs00213545_m1 AB030655 EFEMP2 Hs00213545_m1 NM_014601 EHD2 Hs00277504_m1 NM_020390 EIF5A2 Hs00702673_s1 NM_020390 EIF5A2 Hs00702673_s1 NM_005230 ELK3 Hs00987814_m1 NM_000501 ELN Hs01091772_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_001008707 EML1 Hs00270014_m1 NM_004434 EML1 Hs00270014_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 241 NM_004098 EMX2 Hs00244574_m1 U87967 ENTPD1 Hs00969559_m1 NM_001776 ENTPD1 Hs00739960_s1 NM_001776 ENTPD1 Hs00739960_s1 NM_012156 EPB41L1 Hs00385004_m1 BC000686 EPDR1 Hs00378148_m1 NM_004950 EPYC Hs00191912_m1 NM_004956 ETV1 Hs00290469_s1 NM_147127 EVC2 Hs00377633_m1 NM_014210 EVI2A Hs00204405_m1 NM_000401 EXT2 Hs00181158_m1 NM_000129 F13A1 Hs00173388_m1 NM_001992 F2R Hs00169258_m1 NM_182705 FAM101B Hs00823804_m1 NM_182705 FAM101B Hs00823804_m1 NM_032581 FAM126A Hs00261521_m1 NM_153711 FAM26E Hs00382139_m1 U76833 FAP Hs00990806_m1 NM_000043 FAS Hs00907759_m1 NM_000043 FAS Hs00907759_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001996 FBLN1 Hs00242546_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_006832 FERMT2 Hs01041255_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 NM_000800 FGF1 Hs00265254_m1 NM_003862 FGF18 Hs00818572_m1 NM_001449 FHL1 Hs00793641_g1 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 NM_014890 FILIP1L Hs00706279_s1 NM_017946 FKBP14 Hs00942521_m1 NM_017946 FKBP14 Hs00942521_m1 NM_017946 FKBP14 Hs00942521_m1 AF100751 FKBP7 Hs00535040_m1 NM_007270 FKBP9 Hs00414859_m1 NM_013231 FLRT2 Hs00544171_s1 242 NM_002021 FMO1 Hs00266654_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 BC005858 FN1 Hs00415006_m1 AF130095 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_032532 FNDC1 Hs00287359_m1 NM_022763 FNDC3B Hs00224289_m1 NM_001452 FOXF2 Hs00230963_m1 NM_005197 FOXN3 Hs00830558_g1 NM_002015 FOXO1 Hs00231106_m1 NM_152330 FRMD6 Hs00378563_m1 NM_152330 FRMD6 Hs00378563_m1 NM_013409 FST Hs00246256_m1 NM_006350 FST Hs00246260_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_003505 FZD1 Hs00268943_s1 NM_015675 GADD45B Hs00169587_m1 NM_020474 GALNT1 Hs00234919_m1 NM_020474 GALNT1 Hs00234919_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 L13720 GAS6 Hs01090305_m1 NM_000820 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005110 GFPT2 Hs01049561_m1 NM_005266 GJA5 Hs00270952_s1 M86849 GJB2 Hs00269615_s1 NM_006851 GLIPR1 Hs00199268_m1 NM_006851 GLIPR1 Hs00199268_m1 NM_032575 GLIS2 Hs00402743_g1 NM_152629 GLIS3 Hs00295084_s1 NM_152629 GLIS3 Hs00295084_s1 NM_018446 GLT8D1 Hs00251197_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_004126 GNG11 Hs00914578_m1 NM_018841 GNG12 Hs03005750_m1 243 NM_053064 GNG2 Hs00828232_m1 NM_014498 GOLIM4 Hs00274320_m1 AF111178 GPC6 Hs00170677_m1 NM_005708 GPC6 Hs00170677_m1 NM_002510 GPNMB Hs01095679_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_007223 GPR176 Hs01064696_m1 AF039686 GPR34 Hs00271105_s1 NM_015696 GPX7 Hs00210410_m1 NM_001008397 GPX8 Hs00380670_m1 AF154054 GREM1 Hs00171951_m1 NM_013372 GREM1 Hs00171951_m1 NM_002091 GRP Hs00181852_m1 AF200715 GULP1 Hs00169604_m1 NM_016315 GULP1 Hs00169604_m1 NM_014799 HEPH Hs00953259_m1 NM_000601 HGF Hs00900066_m1 NM_031935 HMCN1 Hs00399043_m1 NM_006895 HNMT Hs00199373_m1 NM_001024074 HNMT Hs02759756_s1 NM_014485 HPGDS Hs00183950_m1 NM_016245 HSD17B11 Hs00212226_m1 NM_003725 HSD17B6 Hs00366258_m1 NM_003725 HSD17B6 Hs00366258_m1 NM_000867 HTR2B Hs00168362_m1 NM_002775 HTRA1 Hs01016151_m1 NM_053044 HTRA3 Hs01099710_m1 NM_053044 HTRA3 Hs01099710_m1 NM_002167 ID3 Hs00171409_m1 BC002857 IFFO1 Hs00209967_m1 NM_005531 IFI16 Hs00986755_m1 NM_020962 IGDCC4 Hs00326335_m1 NM_000618 IGF1 Hs01547657_m1 NM_001007139 IGF2 Hs00277496_s1 NM_000598 IGFBP3 Hs00426289_m1 M31159 IGFBP3 Hs00181211_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_153687 IKBIP Hs00291515_m1 NM_153687 IKBIP Hs00291515_m1 NM_000877 IL1R1 Hs00991002_m1 M13436 INHBA Hs01081598_m1 NM_002192 INHBA Hs01081598_m1 NM_005545 ISLR Hs01921558_s1 244 AF109681 ITGA11 Hs01012939_m1 NM_002210 ITGAV Hs00233808_m1 NM_002211 ITGB1 Hs00236976_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_021999 ITM2B Hs01126287_m1 AF114488 ITSN1 Hs00161676_m1 AF114488 ITSN1 Hs00161676_m1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_175061 JAZF1 Hs00697777_m1 NM_015493 KANK2 Hs00795260_m1 NM_181712 KANK4 Hs00400916_m1 AF160967 KCNMB4 Hs00205704_m1 NM_031954 KCTD10 Hs00230632_m1 NM_138444 KCTD12 Hs00540818_s1 NM_024089 KDELC1 Hs00607574_g1 NM_153705 KDELC2 Hs00794053_m1 NM_007035 KERA Hs00559942_m1 NM_018689 KIAA1199 Hs00378530_m1 NM_019590 KIAA1217 Hs00289569_m1 NM_018012 KIF26B Hs00215977_m1 NM_018240 KIRREL Hs00217307_m1 NM_005655 KLF10 Hs00921811_m1 NM_007249 KLF12 Hs00273134_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002290 LAMA4 Hs00935293_m1 M20206 LAMB1 Hs01055971_m1 NM_002291 LAMB1 Hs01055971_m1 NM_002293 LAMC1 Hs00267056_m1 AF207547 LATS2 Hs00324396_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_001290 LDB2 Hs00609711_m1 NM_001003679 LEPR Hs00900242_m1 NM_022356 LEPRE1 Hs00223565_m1 NM_002305 LGALS1 Hs00355202_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_005779 LHFPL2 Hs00299613_m1 245 NM_199000 LHFPL3 Hs01585188_s1 NM_016357 LIMA1 Hs00212557_m1 NM_004987 LIMS1 Hs00757864_m1 NM_153713 LIX1L Hs00542269_m1 NM_014583 LMCD1 Hs00205871_m1 NM_002317 LOX Hs00942480_m1 NM_002317 LOX Hs00942480_m1 NM_005576 LOXL1 Hs00935937_m1 NM_002318 LOXL2 Hs00158757_m1 NM_001401 LPAR1 Hs00173500_m1 NM_001401 LPAR1 Hs00173500_m1 NM_005767 LPAR6 Hs00271758_s1 NM_015116 LRCH1 Hs00996581_m1 NM_020871 LRCH2 Hs00325819_m1 NM_153377 LRIG3 Hs00957485_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_130830 LRRC15 Hs00370056_s1 NM_005824 LRRC17 Hs00180581_m1 NM_005512 LRRC32 Hs00194136_m1 NM_173491 LSM11 Hs00542854_m1 AF113211 LTBP2 Hs00544640_s1 NM_000428 LTBP2 Hs00544640_s1 NM_002345 LUM Hs00158940_m1 NM_033631 LUZP1 Hs00612276_m1 NM_015364 LY96 Hs00209771_m1 NM_005461 MAFB Hs00271378_s1 NM_005461 MAFB Hs00271378_s1 NM_019066 MAGEL2 Hs00255922_s1 NM_005907 MAN1A1 Hs00195458_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_006575 MAP4K5 Hs00179088_m1 NM_002356 MARCKS Hs00158993_m1 BC004995 MARVELD1 Hs00230362_m1 NM_002381 MATN3 Hs00159081_m1 AF054589 MDFIC Hs00611472_m1 NM_017459 MFAP2 Hs01027737_m1 NM_002404 MFAP4 Hs00412974_m1 U37283 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_014632 MICAL2 Hs01121806_m1 NM_014632 MICAL2 Hs01121806_m1 NM_000248 MITF Hs01117294_m1 246 NM_000248 MITF Hs01117294_m1 NM_005940 MMP11 Hs00171829_m1 NM_005940 MMP11 Hs00171829_m1 NM_002427 MMP13 Hs00942589_m1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 AL136588 MMP16 Hs00540314_s1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 NM_002422 MMP3 Hs00968308_m1 NM_002430 MN1 Hs00159202_m1 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 NM_032476 MRPS6 Hs00606808_m1 NM_002445 MSR1 Hs00234012_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 AF245505 MXRA5 Hs00295630_s1 NM_001008528 MXRA7 Hs00895155_m1 NM_001008528 MXRA7 Hs00895155_m1 NM_032348 MXRA8 Hs00260584_m1 NM_006097 MYL9 Hs00697086_m1 NM_012223 MYO1B Hs00362654_m1 NM_004998 MYO1E Hs00192232_m1 NM_052867 NALCN Hs00291166_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_005380 NBL1 Hs00185054_m1 NM_005380 NBL1 Hs00185054_m1 U35139 NDN Hs00267349_s1 NM_006154 NEDD4 Hs00406454_m1 NM_173808 NEGR1 Hs01584331_m1 NM_173808 NEGR1 Hs01584331_m1 NM_144573 NEXN Hs00332124_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_007361 NID2 Hs01547198_g1 NM_016533 NINJ2 Hs00356576_m1 NM_033120 NKD2 Hs00263909_m1 NM_001189 NKX3-2 Hs00154168_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_016931 NOX4 Hs01558199_m1 247 NM_016588 NRN1 Hs00213192_m1 NM_001024628 NRP1 Hs00826121_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_002526 NT5E Hs01573922_m1 NM_002526 NT5E Hs01573922_m1 NM_016522 NTM Hs00275411_m1 NM_016522 NTM Hs00275411_m1 NM_014840 NUAK1 Hs00934234_m1 NM_019094 NUDT4 Hs00819603_m1 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_015441 OLFML2B Hs00827139_g1 NM_020190 OLFML3 Hs00220180_m1 AF035776 OLR1 Hs00234028_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_182904 P4HA3 Hs00420085_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_000919 PAM Hs00168596_m1 NM_000919 PAM Hs00168596_m1 NM_002581 PAPPA Hs00545593_s1 NM_002581 PAPPA Hs00545593_s1 NM_018222 PARVA Hs00217177_m1 AF237771 PARVA Hs00217177_m1 NM_019035 PCDH18 Hs00251855_m1 AB006757 PCDH7 Hs00361092_m1 NM_002589 PCDH7 Hs00159908_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_000921 PDE3A Hs01012698_m1 AB033831 PDGFC Hs00211916_m1 NM_016205 PDGFC Hs00211916_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 NM_021630 PDLIM2 Hs00222154_m1 NM_005451 PDLIM7 Hs01103929_g1 NM_001006624 PDPN Hs01089982_g1 248 NM_006474 PDPN Hs01089982_g1 NM_001006624 PDPN Hs01089982_g1 NM_014721 PHACTR2 Hs01112111_m1 NM_145753 PHLDB2 Hs00377503_m1 NM_000297 PKD2 Hs00165517_m1 NM_001007267 PLA2R1 Hs00234853_m1 K03226 PLAU Hs00170182_m1 NM_002658 PLAU Hs00170182_m1 U08839 PLAUR Hs00182181_m1 NM_002667 PLN Hs00160179_m1 NM_002667 PLN Hs00160179_m1 NM_005032 PLS3 Hs00192406_m1 NM_020353 PLSCR4 Hs00924823_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_032812 PLXDC2 Hs00262350_m1 NM_005761 PLXNC1 Hs00955621_m1 NM_005761 PLXNC1 Hs00955621_m1 NM_020182 PMEPA1 Hs03987603_g1 NM_020182 PMEPA1 Hs03987603_g1 L03203 PMP22 Hs00165556_m1 NM_153703 PODN Hs00542259_m1 NM_006475 POSTN Hs01566750_m1 D13665 POSTN Hs01566750_m1 NM_001030059 PPAPDC1A Hs00404185_m1 NM_003622 PPFIBP1 Hs00186240_m1 NM_000943 PPIC Hs00181460_m1 NM_000943 PPIC Hs00181460_m1 NM_001198 PRDM1 Hs00153357_m1 AF272898 PRDM6 Hs01373000_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_198859 PRICKLE2 Hs00291033_s1 NM_145040 PRKCDBP Hs00293638_m1 NM_002742 PRKD1 Hs00177037_m1 NM_000313 PROS1 Hs00165590_m1 NM_024841 PRR5L Hs00757785_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_020440 PTGFRN Hs01385989_m1 NM_007039 PTPN21 Hs00234784_m1 NM_002839 PTPRD Hs00295441_s1 NM_002839 PTPRD Hs00295441_s1 NM_002841 PTPRG Hs00892788_m1 NM_002841 PTPRG Hs00892788_m1 249 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 NM_006775 QKI Hs00287641_m1 NM_006775 QKI Hs00287641_m1 NM_006775 QKI Hs00287641_m1 AF161486 RAB23 Hs00212407_m1 NM_016277 RAB23 Hs00212407_m1 NM_006868 RAB31 Hs00199313_m1 NM_006868 RAB31 Hs00199313_m1 AF183421 RAB31 Hs00199313_m1 NM_015577 RAI14 Hs00210238_m1 BC000069 RARRES2 Hs00161209_g1 NM_007368 RASA3 Hs00183698_m1 NM_004841 RASAL2 Hs00183129_m1 NM_006909 RASGRF2 Hs00394798_m1 NM_005822 RCAN2 Hs00195165_m1 NM_001268 RCBTB2 Hs00154390_m1 NM_020650 RCN3 Hs00276633_m1 NM_020650 RCN3 Hs00276633_m1 NM_021111 RECK Hs01019179_m1 NM_002907 RECQL Hs00262956_m1 NM_144629 RFTN2 Hs00376096_m1 NM_005613 RGS4 Hs00194501_m1 NM_017821 RHBDL2 Hs00384848_m1 AL136924 RIN2 Hs00610937_m1 NM_021133 RNASEL Hs00221692_m1 NM_014746 RNF144A Hs00207267_m1 NM_001006932 RPS6KA2 Hs00179731_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001015051 RUNX2 Hs00298328_s1 NM_001015051 RUNX2 Hs00298328_s1 NM_002968 SALL1 Hs00231307_m1 NM_002968 SALL1 Hs00231307_m1 NM_153334 SCARF2 Hs00544847_m1 NM_001006946 SDC1 Hs00896425_g1 NM_002998 SDC2 Hs00299807_m1 NM_012429 SEC14L2 Hs00202756_m1 NM_006364 SEC23A Hs00197232_m1 NM_006364 SEC23A Hs00197232_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_001011553 SEPT7 Hs00792555_m1 250 NM_006216 SERPINE2 Hs00385730_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 AF311912 SFRP2 Hs00293258_m1 NM_003013 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 AL136561 SGIP1 Hs00260297_m1 NM_152621 SGMS2 Hs00380453_m1 NM_001009555 SH3D19 Hs00296942_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_001017995 SH3PXD2B Hs00375183_s1 NM_006884 SHOX2 Hs01059691_m1 AF022654 SHOX2 Hs00243203_m1 NM_052885 SLC2A13 Hs00369423_m1 NM_032826 SLC35B4 Hs00327785_s1 NM_033518 SLC38A5 Hs01012028_m1 NM_032148 SLC41A2 Hs00259767_m1 NM_003043 SLC6A6 Hs00896747_m1 NM_152270 SLFN11 Hs00536981_m1 AF055585 SLIT2 Hs00191193_m1 NM_004787 SLIT2 Hs00191193_m1 NM_003062 SLIT3 Hs00171524_m1 NM_017575 SMG6 Hs00214019_m1 AB014737 SMOC2 Hs00405777_m1 NM_003068 SNAI2 Hs00950344_m1 NM_052870 SNX18 Hs00369367_s1 NM_014011 SOCS5 Hs00751962_s1 AL136896 SOCS5 Hs00367107_m1 NM_020777 SORCS2 Hs00325181_m1 NM_003118 SPARC Hs00277762_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_015535 SPATS2L Hs00274702_m1 AF231124 SPOCK1 Hs00270274_m1 AB051390 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_152594 SPRED1 Hs00544790_m1 251 NM_025106 SPSB1 Hs00228304_m1 NM_025106 SPSB1 Hs00228304_m1 NM_006307 SRPX Hs00196867_m1 NM_014467 SRPX2 Hs00997580_m1 AL136756 SSPN Hs00296706_s1 NM_005086 SSPN Hs00296706_s1 NM_032528 ST6GAL2 Hs00290088_s1 NM_006873 STON1 Hs00538997_m1 NM_015170 SULF1 Hs00290918_m1 NM_015170 SULF1 Hs00290918_m1 NM_015170 SULF1 Hs00290918_m1 NM_018837 SULF2 Hs00378697_m1 NM_018837 SULF2 Hs00378697_m1 NM_033025 SYDE1 Hs00263581_m1 NM_024893 SYNDIG1 Hs00227616_m1 NM_005639 SYT1 Hs00194572_m1 NM_080737 SYTL4 Hs00299039_m1 NM_003186 TAGLN Hs00162558_m1 NM_014604 TAX1BP3 Hs00205924_m1 AF234997 TAX1BP3 Hs00205924_m1 NM_152715 TBCEL Hs00378548_m1 NM_152380 TBX15 Hs00537087_m1 NM_000192 TBX5 Hs00361155_m1 NM_152278 TCEAL7 Hs00385936_m1 NM_003205 TCF12 Hs00918972_m1 NM_003205 TCF12 Hs00918972_m1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 BC001830 TGFB1I1 Hs00210887_m1 J03241 TGFB3 Hs01086000_m1 NM_000358 TGFBI Hs03987596_s1 NM_004612 TGFBR1 Hs00610320_m1 NM_003246 THBS1 Hs00962914_m1 NM_003247 THBS2 Hs01568063_m1 NM_006288 THY1 Hs00264235_s1 NM_006288 THY1 Hs00264235_s1 AL161958 THY1 Hs00264235_s1 NM_021649 TICAM2 Hs01934488_s1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 252 U67195 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_000362 TIMP3 Hs00927216_m1 NM_024600 TMEM204 Hs01061927_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_018647 TNFRSF19 Hs00218634_m1 NM_003326 TNFSF4 Hs00967195_m1 NM_022748 TNS3 Hs00224228_m1 NM_003289 TPM2 Hs00268540_m1 NM_003596 TPST1 Hs00234324_m1 NM_012288 TRAM2 Hs00202213_m1 NM_173084 TRIM59 Hs01868189_s1 NM_003304 TRPC1 Hs00608195_m1 NM_003304 TRPC1 Hs00608195_m1 NM_020856 TSHZ3 Hs02379784_s1 AL136805 TSHZ3 Hs02379784_s1 NM_005725 TSPAN2 Hs00194836_m1 BC002654 TUBB6 Hs00603164_m1 NM_000474 TWIST1 Hs00361186_m1 NM_057179 TWIST2 Hs00382379_m1 NM_020648 TWSG1 Hs00221028_m1 NM_001008224 UACA Hs00326052_m1 AF322916 UACA Hs00326052_m1 AF044221 UBL3 Hs01018736_g1 NM_007106 UBL3 Hs01018736_g1 NM_152277 UBTD2 Hs00742805_s1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 D32039 VCAN Hs01007941_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_014000 VCL Hs00243320_m1 U58111 VEGFC Hs01099206_m1 NM_016206 VGLL3 Hs00275109_s1 NM_016206 VGLL3 Hs00275109_s1 NM_003380 VIM Hs00958116_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_016303 WBP5 Hs02378843_s1 NM_003387 WIPF1 Hs01076141_m1 NM_003882 WISP1 Hs00365573_m1 253 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003881 WISP2 Hs00180242_m1 NM_001002292 WLS Hs01553062_m1 NM_003391 WNT2 Hs00608224_m1 NM_015472 WWTR1 Hs00210007_m1 NM_006106 YAP1 Hs00371735_m1 NM_145166 ZBTB47 Hs00908860_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_030751 ZEB1 Hs01566407_m1 U12170 ZEB1 Hs01566407_m1 NM_014795 ZEB2 Hs00207691_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_024721 ZFHX4 Hs00257312_s1 NM_012082 ZFPM2 Hs00201397_m1 NM_015069 ZNF423 Hs00323880_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 NM_018181 ZNF532 Hs00539543_m1 NCAPG2 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_004300 ACP1 Hs00244706_g1 NM_004301 ACTL6A Hs00188792_m1 NM_018685 ANLN Hs01120433_m1 NM_030920 ANP32E Hs00229474_m1 NM_004900 APOBEC3B Hs00358981_m1 NM_014783 ARHGAP11A Hs02567722_s1 NM_018154 ASF1B Hs00216780_m1 NM_018136 ASPM Hs00250800_m1 NM_018136 ASPM Hs00250800_m1 NM_014109 ATAD2 Hs00905075_m1 NM_014109 ATAD2 Hs00905075_m1 NM_014109 ATAD2 Hs00905075_m1 NM_014109 ATAD2 Hs00905075_m1 NM_003600 AURKA Hs01582073_m1 AB011446 AURKB Hs00945858_g1 NM_000465 BARD1 Hs03987607_g1 NM_000465 BARD1 Hs03987607_g1 AB028869 BIRC5 Hs00153353_m1 NM_001012270 BIRC5 Hs03063352_s1 NM_001168 BIRC5 Hs03063352_s1 NM_000057 BLM Hs01119890_m1 254 NM_000059 BRCA2 Hs00609073_m1 NM_000059 BRCA2 Hs00609073_m1 AF360549 BRIP1 Hs00230743_m1 NM_032043 BRIP1 Hs00230743_m1 NM_018321 BRIX1 Hs00217848_m1 NM_004336 BUB1 Hs01557701_m1 NM_004336 BUB1 Hs01557701_m1 AF043294 BUB1 Hs01557701_m1 NM_001211 BUB1B Hs01084819_m1 NM_145018 C11orf82 Hs00376649_m1 NM_017915 C12orf48 Hs00215575_m1 NM_017915 C12orf48 Hs00215575_m1 NM_024808 C13orf34 Hs00227229_m1 NM_033286 C15orf23 Hs00411667_m1 NM_152259 C15orf42 Hs00738302_m1 NM_025108 C16orf59 Hs00228308_m1 NM_020188 C16orf61 Hs00220174_m1 NM_018186 C1orf112 Hs00216940_m1 BC000209 C1orf135 Hs00225211_m1 NM_024037 C1orf135 Hs00225211_m1 NM_145257 C1orf96 Hs00299198_m1 NM_198566 C5orf34 Hs00399342_m1 NM_178448 C9orf140 Hs00746788_s1 NM_017998 C9orf40 Hs00706688_s1 NM_144508 CASC5 Hs00220608_m1 NM_001224 CASP2 Hs00892481_m1 NM_007276 CBX3 Hs00371848_m1 BC006444 CCDC77 Hs00260625_m1 AF269167 CCDC99 Hs00215019_m1 NM_001237 CCNA2 Hs00996789_g1 NM_001237 CCNA2 Hs00996789_g1 NM_031966 CCNB1 Hs01030103_m1 NM_031966 CCNB1 Hs01030103_m1 NM_004701 CCNB2 Hs01084597_g1 NM_001238 CCNE1 Hs01026536_m1 AF112857 CCNE2 Hs01051894_m1 NM_001762 CCT6A Hs00798979_s1 NM_001255 CDC20 Hs00426680_mH NM_001789 CDC25A Hs00947994_m1 NM_001790 CDC25C Hs00156411_m1 NM_003504 CDC45 Hs00185895_m1 NM_001254 CDC6 Hs00154374_m1 U77949 CDC6 Hs00154374_m1 NM_003503 CDC7 Hs00177487_m1 NM_152562 CDCA2 Hs00401022_m1 255 NM_152562 CDCA2 Hs00401022_m1 NM_031299 CDCA3 Hs00229905_m1 BC002551 CDCA3 Hs00229905_m1 NM_017955 CDCA4 Hs00743989_s1 NM_080668 CDCA5 Hs00293564_m1 AY029179 CDCA7 Hs00230589_m1 BC001651 CDCA8 Hs00983661_m1 NM_001786 CDK1 Hs00364293_m1 NM_001786 CDK1 Hs00364293_m1 D88357 CDK1 Hs00364293_m1 M68520 CDK2 Hs01548894_m1 AF213033 CDKN3 Hs00937841_m1 AF321125 CDT1 Hs00368864_m1 NM_030928 CDT1 Hs00368864_m1 NM_001806 CEBPG Hs01922818_s1 BC002703 CENPA Hs00903938_g1 NM_001809 CENPA Hs00903938_g1 NM_001813 CENPE Hs01068241_m1 U30872 CENPF Hs00193201_m1 NM_022909 CENPH Hs00224722_m1 NM_006733 CENPI Hs00198791_m1 NM_006733 CENPI Hs00198791_m1 BC005400 CENPK Hs00608708_m1 NM_033319 CENPL Hs00378325_m1 NM_024053 CENPM Hs00894704_m1 NM_018455 CENPN Hs00218401_m1 NM_018455 CENPN Hs00218401_m1 NM_024322 CENPO Hs00256990_m1 NM_018132 CENPQ Hs00216695_m1 NM_014985 CEP152 Hs00942685_g1 NM_018131 CEP55 Hs00216688_m1 NM_005483 CHAF1A Hs00193920_m1 NM_005483 CHAF1A Hs00193920_m1 NM_005441 CHAF1B Hs00601414_m1 NM_017812 CHCHD3 Hs00430102_m1 NM_001274 CHEK1 Hs00967513_m1 NM_001274 CHEK1 Hs00967513_m1 NM_001274 CHEK1 Hs00967513_m1 BC004207 CHEK2 Hs00200485_m1 NM_007174 CIT Hs00392339_m1 NM_018204 CKAP2 Hs00217068_m1 NM_152515 CKAP2L Hs00403991_m1 NM_001008938 CKAP5 Hs01120723_m1 NM_001826 CKS1B Hs02518862_g1 NM_001827 CKS2 Hs00854958_g1 256 NM_022111 CLSPN Hs00375405_m1 NM_016207 CPSF3 Hs00211919_m1 AF053641 CSE1L Hs00169158_m1 AF053640 CSE1L Hs00354853_m1 NM_001316 CSE1L Hs00169158_m1 NM_001905 CTPS Hs01041852_m1 AF070448 CTSL2 Hs00952036_m1 NM_003592 CUL1 Hs01117001_m1 NM_006716 DBF4 Hs00272696_m1 NM_005804 DDX39A Hs00271794_m1 NM_003472 DEK Hs01078267_m1 NM_017779 DEPDC1 Hs00854841_g1 NM_017779 DEPDC1 Hs00854841_g1 NM_017779 DEPDC1 Hs00854841_g1 NM_017779 DEPDC1 Hs00854841_g1 NM_018369 DEPDC1B Hs00293551_m1 BC003584 DHFR Hs00758822_s1 BC000192 DHFR Hs00758822_s1 NM_000791 DHFR Hs00758822_s1 NM_000791 DHFR Hs00758822_s1 NM_018706 DHTKD1 Hs00907840_m1 NM_030932 DIAPH3 Hs01107330_m1 U59151 DKC1 Hs00154737_m1 NM_001363 DKC1 Hs00154737_m1 NM_014750 DLGAP5 Hs00207323_m1 NM_015190 DNAJC9 Hs00750059_s1 NM_015190 DNAJC9 Hs00750059_s1 NM_001379 DNMT1 Hs02558036_s1 AF232674 DONSON Hs00375083_m1 NM_024094 DSCC1 Hs00225430_m1 NM_024918 DSN1 Hs01566636_m1 NM_016448 DTL Hs00978565_m1 NM_016448 DTL Hs00978565_m1 NM_012145 DTYMK Hs00992744_m1 M96577 E2F1 Hs00153451_m1 NM_005225 E2F1 Hs00153451_m1 NM_004091 E2F2 Hs00231667_m1 NM_001949 E2F3 Hs00605457_m1 NM_203394 E2F7 Hs00403170_m1 NM_024680 E2F8 Hs00226635_m1 NM_006579 EBP Hs00198130_m1 NM_006579 EBP Hs00198130_m1 NM_018098 ECT2 Hs00216455_m1 NM_018098 ECT2 Hs00216455_m1 NM_017669 ERCC6L Hs00535177_s1 257 NM_012291 ESPL1 Hs00901789_g1 NM_012291 ESPL1 Hs00901789_g1 NM_017697 ESRP1 Hs00214472_m1 NM_020728 ESYT2 Hs00294020_m1 NM_003686 EXO1 Hs00243513_m1 NM_004456 EZH2 Hs01016789_m1 NM_138348 FAM105B Hs00385644_m1 NM_138419 FAM54A Hs00293660_m1 NM_138419 FAM54A Hs00293660_m1 BC005004 FAM64A Hs00760463_s1 NM_207418 FAM72D Hs00822131_m1 NM_030919 FAM83D Hs00383338_m1 NM_000135 FANCA Hs00164555_m1 NM_000135 FANCA Hs00164555_m1 NM_001018115 FANCD2 Hs00945450_m1 NM_004629 FANCG Hs00184947_m1 BC004277 FANCI Hs00383049_m1 NM_018193 FANCI Hs00289551_m1 NM_018193 FANCI Hs00289551_m1 NM_012177 FBXO5 Hs00559989_m1 NM_012177 FBXO5 Hs00559989_m1 NM_004111 FEN1 Hs00748727_s1 BC000323 FEN1 Hs00748727_s1 NM_022116 FIGNL1 Hs01934587_s1 NM_021953 FOXM1 Hs00153543_m1 NM_002041 GABPB1 Hs00242573_m1 NM_174942 GAS2L3 Hs00604175_m1 NM_182625 GEN1 Hs00404087_m1 NM_021067 GINS1 Hs01040835_m1 BC003186 GINS2 Hs00211479_m1 NM_022770 GINS3 Hs00375456_m1 NM_022770 GINS3 Hs00375456_m1 BC005995 GINS4 Hs00260545_m1 NM_015895 GMNN Hs00992846_m1 NM_003875 GMPS Hs00269500_m1 NM_013296 GPSM2 Hs01076888_m1 NM_013296 GPSM2 Hs01076888_m1 NM_012341 GTPBP4 Hs00202558_m1 NM_012341 GTPBP4 Hs00202558_m1 NM_016426 GTSE1 Hs00212681_m1 NM_016426 GTSE1 Hs00212681_m1 NM_016426 GTSE1 Hs00212681_m1 NM_016426 GTSE1 Hs00212681_m1 NM_012412 H2AFV Hs00606542_mH NM_002105 H2AFX Hs00266783_s1 258 NM_002106 H2AFZ Hs01888362_g1 NM_002106 H2AFZ Hs01888362_g1 NM_018063 HELLS Hs00216247_m1 AF155827 HELLS Hs00216247_m1 NM_018410 HJURP Hs00251144_m1 BC000903 HMGB2 Hs01127828_g1 NM_005342 HMGB3 Hs00801334_s1 U29343 HMMR Hs00234864_m1 NM_012485 HMMR Hs00234864_m1 NM_016185 HN1 Hs00602957_m1 NM_194247 HNRNPA3 Hs00864845_s1 NM_004499 HNRNPAB Hs00954054_g1 NM_000194 HPRT1 Hs99999909_m1 NM_016299 HSPA14 Hs00212495_m1 NM_020238 INCENP Hs00220336_m1 NM_178229 IQGAP3 Hs00603642_m1 NM_178229 IQGAP3 Hs00603642_m1 BC005832 KIAA0101 Hs00207134_m1 NM_014736 KIAA0101 Hs00207134_m1 NM_020890 KIAA1524 Hs00405413_m1 NM_004523 KIF11 Hs00189698_m1 NM_014875 KIF14 Hs00208408_m1 NM_014875 KIF14 Hs00208408_m1 NM_020242 KIF15 Hs00173349_m1 NM_031217 KIF18A Hs01015428_m1 NM_005733 KIF20A Hs00993573_m1 NM_016195 KIF20B Hs01027505_m1 NM_004856 KIF23 Hs00370852_m1 NM_004856 KIF23 Hs00370852_m1 AY026505 KIF2C Hs00901710_m1 U63743 KIF2C Hs00901710_m1 NM_012310 KIF4A Hs01020169_m1 BC000712 KIFC1 Hs00382565_m1 NM_018846 KLHL7 Hs01074827_m1 NM_014708 KNTC1 Hs00206854_m1 NM_002266 KPNA2 Hs00818252_g1 BC005978 KPNA2 Hs00818252_g1 NM_000234 LIG1 Hs01553527_m1 NM_173083 LIN9 Hs00542748_m1 NM_005573 LMNB1 Hs00194369_m1 NM_032737 LMNB2 Hs00383326_m1 NM_152329 LRR1 Hs00907947_m1 NM_002358 MAD2L1 Hs00829154_g1 NM_018048 MAGOHB Hs00970279_m1 NM_032844 MASTL Hs00949171_m1 259 AB042719 MCM10 Hs00960349_m1 AL136840 MCM10 Hs00960349_m1 NM_018518 MCM10 Hs00960349_m1 NM_004526 MCM2 Hs01091564_m1 NM_002388 MCM3 Hs00172459_m1 NM_005914 MCM4 Hs00381539_m1 NM_005914 MCM4 Hs00381539_m1 NM_005914 MCM4 Hs00381539_m1 NM_005914 MCM4 Hs00381539_m1 NM_006739 MCM5 Hs01052142_m1 NM_006739 MCM5 Hs01052142_m1 NM_005915 MCM6 Hs00195504_m1 NM_005915 MCM6 Hs00195504_m1 AF279900 MCM7 Hs01097212_m1 D55716 MCM7 Hs01097212_m1 BC005170 MCM8 Hs01067422_m1 NM_014791 MELK Hs01106431_m1 NM_018944 MIS18A Hs00219050_m1 NM_018944 MIS18A Hs00219050_m1 NM_018944 MIS18A Hs00219050_m1 NM_002417 MKI67 Hs01032435_g1 NM_002417 MKI67 Hs01032435_g1 NM_002417 MKI67 Hs01032435_g1 NM_002417 MKI67 Hs01032435_g1 NM_024629 MLF1IP Hs00381676_m1 NM_024629 MLF1IP Hs00381676_m1 NM_024629 MLF1IP Hs00381676_m1 AY028916 MND1 Hs00259549_m1 NM_022782 MPHOSPH9 Hs00224430_m1 BC003375 MRPL3 Hs00246665_m1 NM_020662 MRS2 Hs00252895_m1 U04045 MSH2 Hs00179887_m1 D89646 MSH6 Hs00264721_m1 NM_000179 MSH6 Hs00264721_m1 NM_014342 MTCH2 Hs00819318_g1 NM_005956 MTHFD1 Hs01068263_m1 NM_006636 MTHFD2 Hs00759197_s1 NM_002466 MYBL2 Hs00942543_m1 NM_002482 NASP Hs00267329_m1 NM_014865 NCAPD2 Hs00274505_m1 NM_015261 NCAPD3 Hs01017817_g1 NM_022346 NCAPG Hs00254617_m1 NM_022346 NCAPG Hs00254617_m1 NM_015341 NCAPH Hs01010752_m1 NM_006101 NDC80 Hs00196101_m1 260 NM_018248 NEIL3 Hs00217387_m1 NM_002497 NEK2 Hs00601227_mH NM_032869 NUDCD1 Hs00395650_m1 NM_002452 NUDT1 Hs00159343_m1 BC000025 NUDT5 Hs00274029_m1 AF326731 NUF2 Hs00230097_m1 NM_005124 NUP153 Hs01018919_m1 NM_004298 NUP155 Hs00184876_m1 NM_015135 NUP205 Hs00299654_m1 NM_015135 NUP205 Hs00299654_m1 NM_007280 OIP5 Hs00299079_m1 NM_004153 ORC1 Hs00172751_m1 NM_014321 ORC6 Hs00941236_m1 NM_006452 PAICS Hs00272390_m1 NM_006452 PAICS Hs00272390_m1 NM_018492 PBK Hs00218544_m1 NM_002592 PCNA Hs00952870_g1 NM_014317 PDSS1 Hs00372008_m1 NM_001009936 PHF19 Hs00379166_m1 NM_001009936 PHF19 Hs00379166_m1 NM_025049 PIF1 Hs00228104_m1 NM_004203 PKMYT1 Hs00993622_g1 NM_005030 PLK1 Hs00983233_g1 NM_014264 PLK4 Hs00975273_m1 NM_014264 PLK4 Hs00975273_m1 NM_015426 POC1A Hs00248813_m1 NM_015426 POC1A Hs00248813_m1 NM_016937 POLA1 Hs00415835_m1 NM_002689 POLA2 Hs00160242_m1 NM_002692 POLE2 Hs00160277_m1 U00238 PPAT Hs00601264_m1 NM_015316 PPP1R13B Hs00367408_m1 NM_003981 PRC1 Hs01597831_m1 NM_000946 PRIM1 Hs00265388_m1 NM_000947 PRIM2 Hs00168726_m1 NM_018304 PRR11 Hs00383634_m1 NM_002803 PSMC2 Hs00739800_m1 NM_013290 PSMC3IP Hs00247433_m1 NM_002816 PSMD12 Hs00738496_g1 NM_005805 PSMD14 Hs01113429_m1 NM_004219 PTTG1 Hs00851754_u1 NM_019042 PUS7 Hs00219342_m1 NM_013277 RACGAP1 Hs01100049_mH AF084513 RAD1 Hs00421891_g1 NM_002875 RAD51 Hs00153418_m1 261 NM_006479 RAD51AP1 Hs01548891_m1 NM_012415 RAD54B Hs01066216_m1 NM_003579 RAD54L Hs00269177_m1 AF054183 RAN Hs00741099_g1 NM_002882 RANBP1 Hs01597912_g1 NM_002895 RBL1 Hs00765707_m1 NM_018077 RBM28 Hs00216325_m1 NM_001017919 RCCD1 Hs00364408_m1 NM_002914 RFC2 Hs00945948_m1 M87338 RFC2 Hs00945948_m1 NM_002915 RFC3 Hs00161357_m1 BC000149 RFC3 Hs00161357_m1 NM_002916 RFC4 Hs00427469_m1 NM_007370 RFC5 Hs00738859_m1 BC001866 RFC5 Hs00738859_m1 NM_005614 RHEB Hs00356729_g1 NM_005614 RHEB Hs00356729_g1 NM_005614 RHEB Hs00356729_g1 NM_024945 RMI1 Hs00227878_m1 NM_152308 RMI2 Hs00293870_m1 NM_002936 RNASEH1 Hs00268000_m1 NM_006397 RNASEH2A Hs00197370_m1 NM_032814 RNFT2 Hs01074543_m1 NM_001033 RRM1 Hs01040698_m1 NM_001033 RRM1 Hs01040698_m1 BC001886 RRM2 Hs01072069_g1 NM_001034 RRM2 Hs01072069_g1 NM_001013437 SEH1L Hs01031566_m1 NM_001012409 SGOL1 Hs00386282_m1 NM_152524 SGOL2 Hs00332104_m1 NM_152524 SGOL2 Hs00332104_m1 NM_024745 SHCBP1 Hs00226915_m1 NM_006304 SHFM1 Hs00428732_m1 NM_145060 SKA1 Hs00536843_m1 NM_182620 SKA2 Hs00735057_m1 NM_145061 SKA3 Hs00384927_m1 BC001441 SKP2 Hs00261857_m1 NM_005983 SKP2 Hs01021864_m1 NM_006527 SLBP Hs00153497_m1 NM_014251 SLC25A13 Hs01573628_m1 NM_016045 SLMO2 Hs00429845_m1 NM_006306 SMC1A Hs00196849_m1 NM_006444 SMC2 Hs00197593_m1 NM_006444 SMC2 Hs00197593_m1 AL136877 SMC4 Hs00374522_m1 262 NM_005496 SMC4 Hs00374522_m1 NM_003090 SNRPA1 Hs00795392_mH NM_003090 SNRPA1 Hs00795392_mH NM_003090 SNRPA1 Hs00795392_mH NM_006938 SNRPD1 Hs00705733_s1 BC001721 SNRPD1 Hs00762441_s1 NM_006461 SPAG5 Hs00197708_m1 NM_182513 SPC24 Hs00699347_m1 AF225416 SPC25 Hs00221100_m1 NM_003137 SRPK1 Hs00177298_m1 NM_003143 SSBP1 Hs00268409_m1 NM_003035 STIL Hs00161700_m1 NM_005563 STMN1 Hs01027516_g1 NM_005563 STMN1 Hs01027516_g1 NM_006342 TACC3 Hs00170751_m1 AF151073 TBC1D7 Hs00212898_m1 BC002493 TCF19 Hs00232525_m1 NM_005782 THOC4 Hs00362329_m1 NM_003920 TIMELESS Hs01086966_m1 NM_017858 TIPIN Hs00762756_s1 NM_003258 TK1 Hs01062127_g1 NM_015257 TMEM194A Hs00322591_m1 NM_015257 TMEM194A Hs00322591_m1 NM_032842 TMEM209 Hs00262523_m1 NM_014573 TMEM97 Hs00299877_m1 NM_001032283 TMPO Hs01052569_mH NM_001032283 TMPO Hs01052569_mH NM_001032283 TMPO Hs01052569_mH NM_021992 TMSB15A Hs00751699_s1 NM_012470 TNPO3 Hs01110576_m1 NM_001067 TOP2A Hs03063307_m1 NM_001067 TOP2A Hs03063307_m1 NM_007027 TOPBP1 Hs00199775_m1 AF098158 TPX2 Hs00201616_m1 NM_015905 TRIM24 Hs00234363_m1 NM_003852 TRIM24 Hs00234363_m1 NM_004237 TRIP13 Hs01020069_m1 NM_005480 TROAP Hs01006294_g1 AF080255 TTF2 Hs00186105_m1 NM_003318 TTK Hs00177412_m1 NM_006082 TUBA1B Hs00744842_sH NM_006082 TUBA1B Hs00744842_sH NM_006082 TUBA1B Hs00744842_sH BC006379 TUBA1B Hs00744842_sH BC006481 TUBA1B Hs00744842_sH 263 BC005946 TUBA1C Hs00733770_m1 BC004949 TUBA1C Hs00733770_m1 NM_001071 TYMS Hs00426591_m1 NM_007019 UBE2C Hs00853610_g1 NM_014501 UBE2S Hs00819350_m1 AB032931 UBE2T Hs00204359_m1 NM_014671 UBE3C Hs00904531_m1 NM_015984 UCHL5 Hs00255374_m1 BC002906 UCK2 Hs00367072_m1 NM_013282 UHRF1 Hs01086727_m1 NM_003362 UNG Hs00422172_m1 NM_003368 USP1 Hs00163427_m1 NM_003372 VBP1 Hs00163459_m1 NM_003384 VRK1 Hs00177470_m1 NM_001008396 WDHD1 Hs00173172_m1 NM_001008396 WDHD1 Hs00173172_m1 NM_007086 WDHD1 Hs00173172_m1 NM_018256 WDR12 Hs00372531_g1 NM_024908 WDR76 Hs00227706_m1 NM_024908 WDR76 Hs00227706_m1 AF083389 WHSC1 Hs00324599_m1 D89729 XPO1 Hs00185645_m1 AF298880 XPO5 Hs00382453_m1 NM_007235 XPOT Hs00610636_g1 NM_153695 ZNF367 Hs00400665_m1 NM_017975 ZWILCH Hs00215851_m1 NM_017975 ZWILCH Hs00215851_m1 NM_007057 ZWINT Hs00199952_m1 NSUN2 Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_014109 ATAD2 Hs00905075_m1 NM_018321 BRIX1 Hs00217848_m1 BC006475 C3orf26 Hs00260635_m1 NM_018356 C5orf22 Hs00217966_m1 NM_175921 C5orf51 Hs00420444_m1 NM_031966 CCNB1 Hs01030103_m1 NM_012073 CCT5 Hs00603745_mH NM_032830 CIRH1A Hs00262464_m1 AB045223 CLPTM1L Hs00363947_m1 NM_030782 CLPTM1L Hs00363947_m1 NM_015420 DCAF13 Hs00702585_s1 NM_015420 DCAF13 Hs00702585_s1 NM_004728 DDX21 Hs01056146_m1 264 U59151 DKC1 Hs00154737_m1 NM_001363 DKC1 Hs00154737_m1 BC001144 DNAJB11 Hs00212527_m1 NM_001012339 DNAJC21 Hs00288009_m1 NM_013235 DROSHA Hs00203008_m1 NM_001034915 ESRP1 Hs00214472_m1 NM_138348 FAM105B Hs00385644_m1 NM_207418 FAM72D Hs00822131_m1 NM_024091 FASTKD3 Hs00225414_m1 NM_012341 GTPBP4 Hs00202558_m1 NM_012341 GTPBP4 Hs00202558_m1 BC003353 MED10 Hs00540306_s1 AB049654 MRPL36 Hs00852169_g1 NM_004553 NDUFS6 Hs00190035_m1 NM_032869 NUDCD1 Hs00395650_m1 NM_004298 NUP155 Hs00184876_m1 NM_006451 PAIP1 Hs00603735_g1 BC005295 PAIP1 Hs00603735_g1 NM_006451 PAIP1 Hs00603735_g1 NM_006999 PAPD7 Hs00173159_m1 NM_013232 PDCD6 Hs00202985_m1 NM_033109 PNPT1 Hs00396733_g1 NM_005983 SKP2 Hs01021864_m1 NM_001047 SRD5A1 Hs00602694_mH NM_004237 TRIP13 Hs01020069_m1 NM_015939 TRMT6 Hs00210942_m1 AF298880 XPO5 Hs00382453_m1 NM_007235 XPOT Hs00610636_g1 NM_033414 ZNF622 Hs00369182_m1 OGN Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_000014 A2M Hs00163474_m1 NM_080284 ABCA6 Hs00365329_m1 NM_007168 ABCA8 Hs00992371_m1 NM_080283 ABCA9 Hs00329320_m1 NM_080283 ABCA9 Hs00329320_m1 NM_080283 ABCA9 Hs00329320_m1 AF016535 ABCB1 Hs01067802_m1 AF016535 ABCB1 Hs01067802_m1 AB056106 ABI3BP Hs00248821_m1 NM_001093 ACACB Hs01565927_g1 NM_001613 ACTA2 Hs00426835_g1 NM_001105 ACVR1 Hs00153836_m1 265 NM_001616 ACVR2A Hs00155658_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_025220 ADAM33 Hs00296426_m1 NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_019903 ADD3 Hs00249890_m1 NM_001121 ADD3 Hs00249890_m1 AF153821 ADH1B Hs00605175_m1 M24317 ADH1B Hs00605175_m1 M21692 ADH1B Hs00605175_m1 AF284095 ADRA2A Hs00265081_s1 NM_001129 AEBP1 Hs00937468_m1 NM_006796 AFG3L2 Hs00255224_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_005465 AKT3 Hs00289302_s1 NM_000689 ALDH1A1 Hs00167445_m1 AB015228 ALDH1A2 Hs00180254_m1 NM_001034173 ALDH1L2 Hs00402876_m1 NM_130847 AMOTL1 Hs00294070_m1 AB056476 ANGPTL1 Hs00559786_m1 NM_004673 ANGPTL1 Hs00559786_m1 NM_004673 ANGPTL1 Hs00559786_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_001148 ANK2 Hs00153998_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_000700 ANXA1 Hs00945401_m1 NM_003734 AOC3 Hs00186647_m1 NM_020809 ARHGAP20 Hs00826991_m1 NM_001025616 ARHGAP24 Hs01097580_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_018071 ARHGEF40 Hs00216283_m1 266 NM_018071 ARHGEF40 Hs00216283_m1 NM_032199 ARID5B Hs01382781_m1 AF316824 ASPN Hs00214395_m1 NM_017680 ASPN Hs00214395_m1 NM_020453 ATP10D Hs00935004_m1 NM_001003696 ATP5J Hs01081389_g1 NM_001003803 ATP5S Hs00210402_m1 NM_000332 ATXN1 Hs00165656_m1 NM_021913 AXL Hs01064444_m1 NM_012104 BACE1 Hs01123242_m1 NM_021813 BACH2 Hs00222364_m1 NM_020139 BDH2 Hs01009428_g1 NM_001711 BGN Hs00959143_m1 BC002416 BGN Hs00959143_m1 NM_152414 BHLHE22 Hs01084964_s1 NM_030762 BHLHE41 Hs00229146_m1 NM_017614 BHMT2 Hs00214120_m1 NM_017614 BHMT2 Hs00214120_m1 NM_001204 BMPR2 Hs00176148_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_004330 BNIP2 Hs00972047_m1 AY027658 BOC Hs00264408_m1 NM_033254 BOC Hs00264408_m1 NM_152547 BTNL9 Hs00537320_m1 NM_017787 C10orf26 Hs00740771_s1 NM_014059 C13orf15 Hs00204129_m1 NM_032849 C13orf33 Hs00262558_m1 NM_030945 C1QTNF3 Hs00229569_m1 AF329841 C1QTNF5 Hs00363053_g1 NM_031911 C1QTNF7 Hs00230467_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 AF325503 C2orf40 Hs00260897_m1 NM_000064 C3 Hs00163811_m1 NM_015224 C3orf63 Hs00248615_m1 NM_001001701 C4orf3 Hs00386171_m1 AF329088 C4orf49 Hs00261759_m1 NM_004772 C5orf13 Hs00854282_g1 NM_001007189 C5orf53 Hs00759532_s1 AF313413 C5orf62 Hs00383944_m1 NM_000587 C7 Hs00175109_m1 267 NM_024913 C7orf58 Hs00227735_m1 NM_020925 CACHD1 Hs00326087_m1 NM_000722 CACNA2D1 Hs00984856_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 AF356193 CARD6 Hs01123611_m1 NM_001753 CAV1 Hs00971716_m1 NM_001753 CAV1 Hs00971716_m1 NM_001233 CAV2 Hs00184597_m1 NM_001233 CAV2 Hs00184597_m1 NM_175709 CBX7 Hs00545603_m1 AL136562 CCDC3 Hs00230222_m1 NM_174908 CCDC50 Hs00291696_s1 NM_174908 CCDC50 Hs00291696_s1 AL136609 CCDC8 Hs00540204_s1 NM_032040 CCDC8 Hs00540204_s1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_001759 CCND2 Hs00922419_g1 AF063591 CD200 Hs01033303_m1 NM_020404 CD248 Hs00535586_s1 NM_014880 CD302 Hs00208436_m1 M81104 CD34 Hs00990735_m1 NM_000072 CD36 Hs01567186_m1 NM_012072 CD93 Hs00362607_m1 NM_003671 CDC14B Hs00269351_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_001795 CDH5 Hs00901463_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_000076 CDKN1C Hs00175938_m1 NM_004936 CDKN2B Hs00793225_m1 NM_001801 CDO1 Hs00156447_m1 NM_006561 CELF2 Hs00990166_m1 AB011154 CEP68 Hs00209465_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_000204 CFI Hs00989715_m1 268 NM_003956 CH25H Hs02379634_s1 NM_006614 CHL1 Hs00544069_m1 NM_145234 CHRDL1 Hs00292767_m1 NM_175856 CHSY3 Hs00545664_m1 NM_003613 CILP Hs00173647_m1 NM_005602 CLDN11 Hs00194440_m1 NM_003277 CLDN5 Hs00533949_s1 NM_002975 CLEC11A Hs00161544_m1 BC005810 CLEC11A Hs00161544_m1 NM_175060 CLEC14A Hs00545534_s1 NM_003278 CLEC3B Hs00162844_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 NM_001299 CNN1 Hs00154543_m1 NM_015463 CNRIP1 Hs00384403_m1 NM_021110 COL14A1 Hs00385388_m1 NM_021110 COL14A1 Hs00385388_m1 NM_001855 COL15A1 Hs01559630_m1 NM_001856 COL16A1 Hs00156876_m1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 NM_000393 COL5A2 Hs00893923_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 AY029208 COL6A2 Hs00242484_m1 NM_001849 COL6A2 Hs00242484_m1 NM_004369 COL6A3 Hs00915120_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006091 CORO2B Hs00379744_m1 NM_001864 COX7A1 Hs00156989_m1 NM_001864 COX7A1 Hs00156989_m1 NM_001870 CPA3 Hs00157019_m1 NM_001873 CPE Hs00175676_m1 269 NM_001873 CPE Hs00175676_m1 NM_019609 CPXM1 Hs01566704_g1 NM_198148 CPXM2 Hs00406866_m1 BC006393 CPZ Hs00186333_m1 AL136861 CRISPLD2 Hs00230322_m1 NM_006371 CRTAP Hs00197261_m1 NM_021117 CRY2 Hs00323654_m1 NM_018371 CSGALNACT1 Hs00218054_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_000396 CTSK Hs00166156_m1 NM_001334 CTSO Hs00154656_m1 U20350 CX3CR1 Hs01922583_s1 NM_000609 CXCL12 Hs00930455_m1 AL136693 CYBRD1 Hs00227411_m1 NM_134268 CYGB Hs00370478_m1 NM_000104 CYP1B1 Hs00164383_m1 NM_183075 CYP2U1 Hs00766273_m1 AF003114 CYR61 Hs00998503_g1 NM_001554 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 NM_052954 CYYR1 Hs00364793_m1 NM_015345 DAAM2 Hs00322497_m1 BC003064 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_002036 DARC Hs01011079_s1 NM_003737 DCHS1 Hs01044548_m1 NM_001920 DCN Hs00754870_s1 AF138303 DCN Hs00266491_m1 NM_001920 DCN Hs00754870_s1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_006182 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_014974 DIP2C Hs00324224_m1 NM_033425 DIXDC1 Hs00736707_m1 NM_014421 DKK2 Hs00205294_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 AF026219 DLC1 Hs00931487_m1 270 NM_006094 DLC1 Hs00183436_m1 NM_001005336 DNM1 Hs00189369_m1 M74777 DPP4 Hs00175210_m1 NM_001935 DPP4 Hs00175210_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001386 DPYSL2 Hs00954558_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_013352 DSE Hs00203441_m1 NM_032160 DSEL Hs00707488_s1 NM_001723 DST Hs00794953_m1 NM_001723 DST Hs00794953_m1 NM_001723 DST Hs00794953_m1 NM_004417 DUSP1 Hs00610257_g1 NM_014934 DZIP1 Hs00208790_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_001005463 EBF3 Hs00291943_s1 NM_001393 ECM2 Hs00154821_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 NM_001957 EDNRA Hs03988672_m1 AB030655 EFEMP2 Hs00213545_m1 NM_016938 EFEMP2 Hs00213545_m1 NM_181723 EFHA2 Hs01028469_m1 NM_152403 EGFLAM Hs00794831_m1 NM_001964 EGR1 Hs00152928_m1 NM_001964 EGR1 Hs00152928_m1 NM_001964 EGR1 Hs00152928_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_005230 ELK3 Hs00987814_m1 NM_000501 ELN Hs01091772_m1 NM_022159 ELTD1 Hs03987598_m1 NM_016242 EMCN Hs01038209_m1 AF205940 EMCN Hs01038209_m1 NM_016242 EMCN Hs01038209_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_004434 EML1 Hs00270014_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_004098 EMX2 Hs00244574_m1 271 L35594 ENPP2 Hs00196470_m1 NM_001776 ENTPD1 Hs00739960_s1 NM_001430 EPAS1 Hs01026142_m1 NM_001431 EPB41L2 Hs00154988_m1 NM_004449 ERG Hs01554635_m1 NM_005239 ETS2 Hs00232009_m1 NM_147127 EVC2 Hs00377633_m1 NM_000129 F13A1 Hs00173388_m1 NM_001992 F2R Hs00169258_m1 NM_004101 F2RL2 Hs00187982_m1 NM_138333 FAM122A Hs00540770_s1 NM_032581 FAM126A Hs00261521_m1 NM_032042 FAM172A Hs00230742_m1 U76833 FAP Hs00990806_m1 NM_000043 FAS Hs00907759_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001996 FBLN1 Hs00242546_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 NM_153214 FBLN7 Hs00402230_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_012158 FBXL3 Hs01045265_m1 BC005912 FCER1A Hs00758600_m1 NM_006832 FERMT2 Hs01041255_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 NM_000800 FGF1 Hs00265254_m1 NM_003862 FGF18 Hs00818572_m1 NM_003862 FGF18 Hs00818572_m1 NM_002009 FGF7 Hs00173565_m1 U29538 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 AF098518 FHL1 Hs00793641_g1 AF063002 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 NM_004469 FIGF Hs00189521_m1 NM_014890 FILIP1L Hs00706279_s1 NM_017946 FKBP14 Hs00942521_m1 272 AF100751 FKBP7 Hs00535040_m1 NM_007270 FKBP9 Hs00414859_m1 NM_207422 FLJ44635 Hs00885839_s1 NM_001458 FLNC Hs00155124_m1 AF169676 FLRT2 Hs00544171_s1 NM_013231 FLRT2 Hs00544171_s1 NM_001460 FMO2 Hs00155158_m1 NM_002023 FMOD Hs00157619_m1 BC004490 FOS Hs01119267_g1 NM_001452 FOXF2 Hs00230963_m1 NM_005197 FOXN3 Hs00830558_g1 NM_005197 FOXN3 Hs00830558_g1 NM_002015 FOXO1 Hs00231106_m1 NM_144966 FREM1 Hs00381549_m1 NM_144966 FREM1 Hs00381549_m1 NM_152330 FRMD6 Hs00378563_m1 NM_152330 FRMD6 Hs00378563_m1 NM_001463 FRZB Hs00173503_m1 U91903 FRZB Hs00173503_m1 NM_013409 FST Hs00246256_m1 NM_006350 FST Hs00246260_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_000148 FUT1 Hs00355741_m1 NM_005031 FXYD1 Hs00245327_m1 NM_003507 FZD7 Hs00275833_s1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 L13720 GAS6 Hs01090305_m1 NM_000820 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 NM_003644 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005261 GEM Hs00738924_m1 NM_005110 GFPT2 Hs01049561_m1 NM_017655 GIPC2 Hs00214273_m1 NM_005270 GLI2 Hs00257977_m1 NM_032575 GLIS2 Hs00402743_g1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_004126 GNG11 Hs00914578_m1 NM_018841 GNG12 Hs03005750_m1 273 NM_053064 GNG2 Hs00828232_m1 NM_014498 GOLIM4 Hs00274320_m1 NM_020918 GPAM Hs01573680_m1 NM_015234 GPR116 Hs00391810_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_198827 GPR133 Hs00914797_m1 NM_014710 GPRASP1 Hs01932892_s1 NM_001004051 GPRASP2 Hs01121555_s1 NM_023927 GRAMD3 Hs00225077_m1 NM_002091 GRP Hs00181852_m1 NM_000177 GSN Hs00388617_m1 NM_016315 GULP1 Hs00169604_m1 AF200715 GULP1 Hs00169604_m1 NM_016315 GULP1 Hs00169604_m1 NR_002196 H19 Hs00262142_g1 NR_002196 H19 Hs00262142_g1 NM_014571 HEYL Hs01113778_m1 NM_000601 HGF Hs00900066_m1 NM_002126 HLF Hs00171406_m1 M95585 HLF Hs00171406_m1 NM_002126 HLF Hs00171406_m1 NM_031935 HMCN1 Hs00399043_m1 NM_006895 HNMT Hs00199373_m1 NM_001024074 HNMT Hs02759756_s1 NM_030661 HOXA3 Hs00601076_m1 NM_019102 HOXA5 Hs00430330_m1 NM_016245 HSD17B11 Hs00212226_m1 NM_052970 HSPA12B Hs00369554_m1 NM_144617 HSPB6 Hs00328933_m1 M85289 HSPG2 Hs01078536_m1 NM_000867 HTR2B Hs00168362_m1 NM_002775 HTRA1 Hs01016151_m1 NM_002167 ID3 Hs00171409_m1 NM_001546 ID4 Hs00155465_m1 NM_001546 ID4 Hs00155465_m1 NM_020962 IGDCC4 Hs00326335_m1 M37484 IGF1 Hs01547657_m1 M29644 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_000612 IGF2 Hs00277496_s1 NM_001007139 IGF2 Hs00277496_s1 NM_002178 IGFBP6 Hs00942697_m1 NM_001553 IGFBP7 Hs00944483_m1 274 NM_001553 IGFBP7 Hs00944483_m1 NM_178822 IGSF10 Hs00975906_m1 NM_004512 IL11RA Hs00234415_m1 NM_138284 IL17D Hs00370528_m1 NM_000877 IL1R1 Hs00991002_m1 AB024518 IL33 Hs00369211_m1 AF128846 INMT Hs00198941_m1 NM_002194 INPP1 Hs00181856_m1 AY009128 ISCU Hs00396806_m1 NM_005545 ISLR Hs01921558_s1 NM_002206 ITGA7 Hs00174397_m1 NM_002210 ITGAV Hs00233808_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_002213 ITGB5 Hs00174435_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_030569 ITIH5 Hs00262393_s1 NM_004867 ITM2A Hs01011360_g1 NM_004867 ITM2A Hs01011360_g1 NM_021999 ITM2B Hs01126287_m1 NM_001001132 ITSN1 Hs00161676_m1 AF114488 ITSN1 Hs00161676_m1 AF114488 ITSN1 Hs00161676_m1 NM_000214 JAG1 Hs01070036_m1 U73936 JAG1 Hs01070036_m1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_175061 JAZF1 Hs00697777_m1 NM_015493 KANK2 Hs00795260_m1 AF160967 KCNMB4 Hs00205704_m1 NM_138444 KCTD12 Hs00540818_s1 NM_138444 KCTD12 Hs00540818_s1 NM_024089 KDELC1 Hs00607574_g1 NM_153705 KDELC2 Hs00794053_m1 NM_007035 KERA Hs00559942_m1 NM_014686 KIAA0355 Hs00206664_m1 NM_019590 KIAA1217 Hs00289569_m1 NM_018240 KIRREL Hs00217307_m1 NM_000222 KIT Hs00922202_m1 NM_007249 KLF12 Hs00273134_m1 NM_016270 KLF2 Hs00360439_g1 NM_001206 KLF9 Hs00230918_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 275 NM_000426 LAMA2 Hs01124081_m1 NM_002290 LAMA4 Hs00935293_m1 M20206 LAMB1 Hs01055971_m1 NM_002291 LAMB1 Hs01055971_m1 NM_002293 LAMC1 Hs00267056_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_181714 LCA5 Hs01099550_m1 NM_001290 LDB2 Hs00609711_m1 NM_001003679 LEPR Hs00900242_m1 NM_001003679 LEPR Hs00900242_m1 U50748 LEPR Hs00900242_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_199000 LHFPL3 Hs01585188_s1 NM_002310 LIFR Hs01123581_m1 BC001247 LIMA1 Hs00212557_m1 NM_016357 LIMA1 Hs00212557_m1 NM_153713 LIX1L Hs00542269_m1 NM_005574 LMO2 Hs00277106_m1 NM_012134 LMOD1 Hs00201704_m1 NM_002317 LOX Hs00942480_m1 NM_005576 LOXL1 Hs00935937_m1 NM_001401 LPAR1 Hs00173500_m1 NM_001401 LPAR1 Hs00173500_m1 NM_005767 LPAR6 Hs00271758_s1 NM_017839 LPCAT2 Hs00215225_m1 NM_012302 LPHN2 Hs00202347_m1 NM_000237 LPL Hs01012571_m1 NM_000237 LPL Hs01012571_m1 NM_015116 LRCH1 Hs00996581_m1 NM_020871 LRCH2 Hs00325819_m1 NM_153377 LRIG3 Hs00957485_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_130830 LRRC15 Hs00370056_s1 NM_005824 LRRC17 Hs00180581_m1 NM_005512 LRRC32 Hs00194136_m1 NM_181506 LRRC70 Hs00704102_s1 BC004958 LRRFIP1 Hs00384213_m1 NM_018334 LRRN3 Hs00539582_s1 AL442092 LRRN3 Hs00539582_s1 NM_000428 LTBP2 Hs00544640_s1 AF113211 LTBP2 Hs00544640_s1 276 NM_002345 LUM Hs00158940_m1 NM_002345 LUM Hs00158940_m1 NM_005584 MAB21L1 Hs00366575_s1 NM_005461 MAFB Hs00271378_s1 NM_019066 MAGEL2 Hs00255922_s1 NM_153267 MAMDC2 Hs00299196_m1 NM_005907 MAN1A1 Hs00195458_m1 BC004995 MARVELD1 Hs00230362_m1 NM_002381 MATN3 Hs00159081_m1 NM_002397 MEF2C Hs00231149_m1 NM_002397 MEF2C Hs00231149_m1 NM_002398 MEIS1 Hs01017441_m1 NM_004527 MEOX1 Hs00244943_m1 NM_005924 MEOX2 Hs00232248_m1 NM_017459 MFAP2 Hs01027737_m1 NM_002404 MFAP4 Hs00412974_m1 NM_003480 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 NM_000248 MITF Hs01117294_m1 AL136588 MMP16 Hs00540314_s1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 NM_007351 MMRN1 Hs00201182_m1 NM_024756 MMRN2 Hs00226971_m1 NM_024756 MMRN2 Hs00226971_m1 NM_002430 MN1 Hs00159202_m1 NM_024761 MOBKL2B Hs00257351_m1 NM_024761 MOBKL2B Hs00257351_m1 NM_023075 MPPE1 Hs00372745_g1 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 AF245505 MXRA5 Hs00295630_s1 NM_032348 MXRA8 Hs00260584_m1 NM_025107 MYCT1 Hs00228305_m1 NM_002474 MYH11 Hs00224610_m1 NM_022844 MYH11 Hs00224622_m1 NM_006097 MYL9 Hs00697086_m1 NM_005467 NAALAD2 Hs01119919_m1 NM_052867 NALCN Hs00291166_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_005380 NBL1 Hs00185054_m1 NM_005380 NBL1 Hs00185054_m1 277 U35139 NDN Hs00267349_s1 NM_022351 NECAB1 Hs00332733_m1 NM_173808 NEGR1 Hs01584331_m1 NM_173808 NEGR1 Hs01584331_m1 NM_144573 NEXN Hs00332124_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_007361 NID2 Hs01547198_g1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_002514 NOV Hs00159631_m1 NM_002514 NOV Hs00159631_m1 NM_005654 NR2F1 Hs00818842_m1 U01351 NR3C1 Hs00230818_m1 X03348 NR3C1 Hs00354508_m1 NM_016588 NRN1 Hs00213192_m1 NM_001024628 NRP1 Hs00826121_m1 AF278532 NTN4 Hs00221915_m1 NM_014840 NUAK1 Hs00934234_m1 NM_019094 NUDT4 Hs00819603_m1 NM_178507 OAF Hs00420156_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_015441 OLFML2B Hs00827139_g1 NM_020190 OLFML3 Hs00220180_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_182904 P4HA3 Hs00420085_m1 NM_016081 PALLD Hs01082959_m1 NM_016081 PALLD Hs01082959_m1 NM_017734 PALMD Hs00214675_m1 NM_001001991 PAMR1 Hs00405837_m1 NM_173462 PAPLN Hs00404545_m1 NM_057177 PARD3B Hs00365140_m1 AF237771 PARVA Hs00217177_m1 NM_018222 PARVA Hs00217177_m1 NM_019035 PCDH18 Hs00251855_m1 NM_019035 PCDH18 Hs00251855_m1 AB006757 PCDH7 Hs00361092_m1 NM_002589 PCDH7 Hs00159908_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_001003683 PDE1A Hs00192346_m1 278 NM_001003683 PDE1A Hs00192346_m1 NM_001003683 PDE1A Hs00192346_m1 NM_005019 PDE1A Hs00897273_m1 NM_002599 PDE2A Hs01042255_m1 NM_000921 PDE3A Hs01012698_m1 NM_000921 PDE3A Hs01012698_m1 NM_018945 PDE7B Hs01054008_m1 NM_016205 PDGFC Hs00211916_m1 AB033832 PDGFD Hs00937332_m1 NM_025208 PDGFD Hs00937332_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 NM_002612 PDK4 Hs01037704_m1 NM_021630 PDLIM2 Hs00222154_m1 AF338650 PDZD2 Hs00389477_m1 NM_015009 PDZRN3 Hs00392900_m1 NM_000442 PECAM1 Hs00169777_m1 NM_021255 PELI2 Hs01012262_mH NM_021965 PGM5 Hs00222671_m1 NM_015157 PHLDB1 Hs00384827_m1 NM_145753 PHLDB2 Hs00377503_m1 NM_017933 PID1 Hs00952182_m1 NM_000297 PKD2 Hs00165517_m1 NM_001007267 PLA2R1 Hs00234853_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_006718 PLAGL1 Hs00414677_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_172069 PLEKHH2 Hs01377275_m1 NM_002667 PLN Hs00160179_m1 NM_002667 PLN Hs00160179_m1 NM_005032 PLS3 Hs00192406_m1 NM_020353 PLSCR4 Hs00924823_m1 NM_020405 PLXDC1 Hs00220723_m1 L03203 PMP22 Hs00165556_m1 NM_153703 PODN Hs00542259_m1 D13665 POSTN Hs01566750_m1 AB000888 PPAP2A Hs00170356_m1 AF014403 PPAP2A Hs00170356_m1 NM_003713 PPAP2B Hs00170359_m1 AB000889 PPAP2B Hs00170359_m1 NM_003713 PPAP2B Hs00170359_m1 NM_000943 PPIC Hs00181460_m1 AF324888 PPP1R12B Hs00364082_m1 279 AF272898 PRDM6 Hs01373000_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_198859 PRICKLE2 Hs00291033_s1 NM_145040 PRKCDBP Hs00293638_m1 NM_002742 PRKD1 Hs00177037_m1 NM_000313 PROS1 Hs00165590_m1 NM_024841 PRR5L Hs00757785_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_000314 PTEN Hs01920652_s1 NM_000314 PTEN Hs01920652_s1 NM_020440 PTGFRN Hs01385989_m1 NM_000961 PTGIS Hs00919949_m1 M57399 PTN Hs00383235_m1 NM_002825 PTN Hs00383235_m1 BC005916 PTN Hs00383235_m1 NM_007039 PTPN21 Hs00234784_m1 NM_002837 PTPRB Hs01549049_m1 NM_002837 PTPRB Hs01549049_m1 NM_002841 PTPRG Hs00892788_m1 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 NM_014904 RAB11FIP2 Hs00208593_m1 NM_016277 RAB23 Hs00212407_m1 BC000069 RARRES2 Hs00161209_g1 NM_006909 RASGRF2 Hs00394798_m1 NM_016563 RASL12 Hs00275429_m1 NM_001031695 RBFOX2 Hs00329214_s1 NM_014483 RBMS3 Hs00205567_m1 NM_005822 RCAN2 Hs00195165_m1 NM_001268 RCBTB2 Hs00154390_m1 NM_021111 RECK Hs01019179_m1 NM_144629 RFTN2 Hs00376096_m1 AF186779 RGL1 Hs00248508_m1 AF159570 RGS5 Hs00186212_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 AL136924 RIN2 Hs00610937_m1 NM_002937 RNASE4 Hs00268002_s1 280 NM_014746 RNF144A Hs00207267_m1 NM_178532 RNF180 Hs00400379_m1 NM_178532 RNF180 Hs00400379_m1 NM_019055 ROBO4 Hs00219408_m1 NM_001006932 RPS6KA2 Hs00179731_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001015051 RUNX2 Hs00298328_s1 NM_001400 S1PR1 Hs01922614_s1 NM_173833 SCARA5 Hs01073151_m1 NM_173833 SCARA5 Hs01073151_m1 NM_153334 SCARF2 Hs00544847_m1 NM_004588 SCN2B Hs00190186_m1 NM_174934 SCN4B Hs00545394_m1 NM_002976 SCN7A Hs00161546_m1 NM_004657 SDPR Hs00190538_m1 NM_006364 SEC23A Hs00197232_m1 NM_003005 SELP Hs00356351_m1 NM_003966 SEMA5A Hs01549381_m1 NM_020858 SEMA6D Hs00227965_m1 NM_005410 SEPP1 Hs00193657_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 NM_006216 SERPINE2 Hs00385730_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 AF311912 SFRP2 Hs00293258_m1 NM_003013 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_031469 SH3BGRL2 Hs00230283_m1 NM_001009555 SH3D19 Hs00296942_m1 NM_016009 SH3GLB1 Hs00211220_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_001017995 SH3PXD2B Hs00375183_s1 AF022654 SHOX2 Hs00243203_m1 AL136944 SLC40A1 Hs00205888_m1 AF055585 SLIT2 Hs00191193_m1 281 NM_004787 SLIT2 Hs00191193_m1 AB011538 SLIT3 Hs00171524_m1 NM_003062 SLIT3 Hs00171524_m1 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 AB014737 SMOC2 Hs00405777_m1 NM_003068 SNAI2 Hs00950344_m1 NM_005460 SNCAIP Hs00193814_m1 NM_003099 SNX1 Hs00162052_m1 NM_018013 SOBP Hs00215979_m1 NM_003877 SOCS2 Hs00919620_m1 AL136896 SOCS5 Hs00367107_m1 NM_014011 SOCS5 Hs00751962_s1 NM_015385 SORBS1 Hs00908953_m1 NM_020777 SORCS2 Hs00325181_m1 NM_022454 SOX17 Hs00751752_s1 NM_031439 SOX7 Hs00846731_s1 NM_003118 SPARC Hs00277762_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_015087 SPG20 Hs00374834_m1 AF231124 SPOCK1 Hs00270274_m1 AB051390 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_005841 SPRY1 Hs01083036_s1 NM_005842 SPRY2 Hs01921749_s1 NM_006307 SRPX Hs00196867_m1 NM_014467 SRPX2 Hs00997580_m1 NM_005086 SSPN Hs00296706_s1 AL136756 SSPN Hs00296706_s1 NM_005086 SSPN Hs00296706_s1 NM_032528 ST6GAL2 Hs00290088_s1 NM_003174 SVIL Hs00931028_m1 NM_024893 SYNDIG1 Hs00227616_m1 NM_007286 SYNPO Hs00702468_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_080737 SYTL4 Hs00299039_m1 NM_006283 TACC1 Hs00180691_m1 NM_003186 TAGLN Hs00162558_m1 NM_015079 TBC1D2B Hs00534954_m1 282 NM_152380 TBX15 Hs00537087_m1 NM_000192 TBX5 Hs00361155_m1 NM_152278 TCEAL7 Hs00385936_m1 NM_003205 TCF12 Hs00918972_m1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_030756 TCF7L2 Hs01009038_m1 NM_000459 TEK Hs00945146_m1 NM_015319 TENC1 Hs00539247_m1 BC001830 TGFB1I1 Hs00210887_m1 J03241 TGFB3 Hs01086000_m1 NM_003247 THBS2 Hs01568063_m1 NM_003248 THBS4 Hs00170261_m1 NM_018676 THSD1 Hs00218756_m1 AL161958 THY1 Hs00264235_s1 NM_005424 TIE1 Hs00892696_m1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 NM_000362 TIMP3 Hs00927216_m1 NM_004614 TK2 Hs00936918_m1 NM_007005 TLE4 Hs00276083_s1 AB002318 TLN2 Hs00322257_m1 NM_018286 TMEM100 Hs00388033_m1 NM_024600 TMEM204 Hs01061927_m1 NM_022093 TNN Hs00295597_m1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_003289 TPM2 Hs00268540_m1 NM_003596 TPST1 Hs00234324_m1 NM_012288 TRAM2 Hs00202213_m1 NM_003304 TRPC1 Hs00608195_m1 NM_003304 TRPC1 Hs00608195_m1 NM_006022 TSC22D1 Hs01553786_m1 283 NM_173485 TSHZ2 Hs00251507_s1 NM_173485 TSHZ2 Hs00251507_s1 NM_173485 TSHZ2 Hs00251507_s1 NM_020856 TSHZ3 Hs02379784_s1 AL136805 TSHZ3 Hs02379784_s1 NM_005725 TSPAN2 Hs00194836_m1 NM_004615 TSPAN7 Hs00190284_m1 AB028966 TTC28 Hs01117728_m1 NM_000474 TWIST1 Hs00361186_m1 NM_057179 TWIST2 Hs00382379_m1 NM_006472 TXNIP Hs01006900_g1 NM_001008224 UACA Hs00326052_m1 AF322916 UACA Hs00326052_m1 NM_007106 UBL3 Hs01018736_g1 NM_007124 UTRN Hs01126016_m1 D32039 VCAN Hs01007941_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_016206 VGLL3 Hs00275109_s1 NM_016206 VGLL3 Hs00275109_s1 NM_003380 VIM Hs00958116_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_000552 VWF Hs00169795_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003881 WISP2 Hs00180242_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_001002292 WLS Hs01553062_m1 NM_015472 WWTR1 Hs00210007_m1 NM_006106 YAP1 Hs00371735_m1 NM_015642 ZBTB20 Hs00210321_m1 NM_015642 ZBTB20 Hs00210321_m1 NM_145166 ZBTB47 Hs00908860_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_030751 ZEB1 Hs01566407_m1 U12170 ZEB1 Hs01566407_m1 NM_014795 ZEB2 Hs00207691_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_024721 ZFHX4 Hs00257312_s1 284 NM_022473 ZFP106 Hs00223868_m1 NM_006887 ZFP36L2 Hs00272828_m1 NM_012082 ZFPM2 Hs00201397_m1 NM_015069 ZNF423 Hs00323880_m1 NM_030634 ZNF436 Hs00535922_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 PIP Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') M73069 AR Hs00907244_m1 AF162704 AR Hs00907244_m1 D90427 AZGP1 Hs00426651_m1 NM_001185 AZGP1 Hs00426651_m1 NM_025057 C14orf45 Hs00228117_m1 NM_030806 C1orf21 Hs00229347_m1 NM_030806 C1orf21 Hs00229347_m1 NM_152400 C4orf32 Hs03043968_m1 NM_024843 CYBRD1 Hs00227411_m1 AL136693 CYBRD1 Hs00227411_m1 NM_178033 CYP4X1 Hs00380077_m1 NM_178134 CYP4Z1 Hs00419990_m1 NM_012153 EHF Hs00171917_m1 AL136939 ELOVL5 Hs01094711_m1 AF233336 EPHX2 Hs00157403_m1 NM_145235 FANK1 Hs01113524_m1 NM_001461 FMO5 Hs00356233_m1 NM_004496 FOXA1 Hs00270129_m1 NM_017423 GALNT7 Hs00213624_m1 NM_005518 HMGCS2 Hs00985427_m1 NM_020775 KIAA1324 Hs00331399_m1 NM_019600 KIAA1370 Hs00325311_m1 NM_015254 KIF13B Hs00209573_m1 NM_014988 LIMCH1 Hs00405524_m1 NM_014988 LIMCH1 Hs00405524_m1 AB050468 LRIG1 Hs00394267_m1 NM_002343 LTF Hs00914330_m1 NM_005595 NFIA Hs00325656_m1 NM_052946 NOSTRIN Hs00976555_m1 AF278532 NTN4 Hs00221915_m1 BC000915 PDLIM1 Hs00253222_m1 NM_003022 SH3BGRL Hs00161654_m1 NM_003022 SH3BGRL Hs00161654_m1 NM_152332 TC2N Hs00541117_m1 285 PRELP Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_000014 A2M Hs00163474_m1 NM_007168 ABCA8 Hs00992371_m1 AB056106 ABI3BP Hs00248821_m1 NM_001613 ACTA2 Hs00426835_g1 NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_015833 ADARB1 Hs00953724_m1 NM_001129 AEBP1 Hs00937468_m1 NM_006796 AFG3L2 Hs00255224_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_005465 AKT3 Hs00289302_s1 NM_000689 ALDH1A1 Hs00167445_m1 NM_130847 AMOTL1 Hs00294070_m1 NM_004673 ANGPTL1 Hs00559786_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_001148 ANK2 Hs00153998_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_003734 AOC3 Hs00186647_m1 NM_001025616 ARHGAP24 Hs01097580_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_001007026 ATN1 Hs00157312_m1 NM_001003696 ATP5J Hs01081389_g1 NM_001003803 ATP5S Hs00210402_m1 NM_021913 AXL Hs01064444_m1 NM_001711 BGN Hs00959143_m1 BC002416 BGN Hs00959143_m1 NM_001711 BGN Hs00959143_m1 NM_152414 BHLHE22 Hs01084964_s1 NM_017614 BHMT2 Hs00214120_m1 NM_017614 BHMT2 Hs00214120_m1 AY027658 BOC Hs00264408_m1 NM_033254 BOC Hs00264408_m1 NM_007021 C10orf10 Hs00199735_m1 AL136653 C10orf10 Hs00199735_m1 286 NM_030968 C1QTNF1 Hs00945123_m1 AF329841 C1QTNF5 Hs00363053_g1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_012261 C20orf103 Hs00935891_m1 NM_000064 C3 Hs00163811_m1 AF329088 C4orf49 Hs00261759_m1 NM_024913 C7orf58 Hs00227735_m1 NM_004342 CALD1 Hs00921982_m1 AF356193 CARD6 Hs01123611_m1 NM_001753 CAV1 Hs00971716_m1 NM_001753 CAV1 Hs00971716_m1 NM_001233 CAV2 Hs00184597_m1 NM_001233 CAV2 Hs00184597_m1 AL136562 CCDC3 Hs00230222_m1 NM_174908 CCDC50 Hs00291696_s1 NM_032040 CCDC8 Hs00540204_s1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_001759 CCND2 Hs00922419_g1 NM_003671 CDC14B Hs00269351_m1 NM_001795 CDH5 Hs00901463_m1 NM_004936 CDKN2B Hs00793225_m1 NM_001801 CDO1 Hs00156447_m1 U69546 CELF2 Hs00990166_m1 NM_006561 CELF2 Hs00990166_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_145234 CHRDL1 Hs00292767_m1 AB017915 CHST3 Hs01000045_m1 NM_015526 CLIP3 Hs00367493_m1 NM_004368 CNN2 Hs00854264_s1 NM_015463 CNRIP1 Hs00384403_m1 NM_021110 COL14A1 Hs00385388_m1 NM_001856 COL16A1 Hs00156876_m1 NM_001849 COL6A2 Hs00242484_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_000095 COMP Hs00164359_m1 NM_016429 COPZ2 Hs00212698_m1 NM_198148 CPXM2 Hs00406866_m1 NM_198148 CPXM2 Hs00406866_m1 BC006393 CPZ Hs00186333_m1 287 AL136861 CRISPLD2 Hs00230322_m1 AF007162 CRYAB Hs00157107_m1 M92934 CTGF Hs00170014_m1 NM_000398 CYB5R3 Hs00240921_m1 NM_134268 CYGB Hs00370478_m1 NM_183075 CYP2U1 Hs00766273_m1 NM_001554 CYR61 Hs00998503_g1 NM_004227 CYTH3 Hs00188456_m1 NM_052954 CYYR1 Hs00364793_m1 BC003064 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_003737 DCHS1 Hs01044548_m1 AF138302 DCN Hs00370385_m1 AF138303 DCN Hs00266491_m1 NM_001920 DCN Hs00754870_s1 NM_001920 DCN Hs00754870_s1 NM_006182 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_014421 DKK2 Hs00205294_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 AF026219 DLC1 Hs00931487_m1 NM_006094 DLC1 Hs00183436_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001386 DPYSL2 Hs00954558_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_001393 ECM2 Hs00154821_m1 NM_016938 EFEMP2 Hs00213545_m1 AB030655 EFEMP2 Hs00213545_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_000501 ELN Hs01091772_m1 NM_001431 EPB41L2 Hs00154988_m1 NM_004449 ERG Hs01554635_m1 NM_147127 EVC2 Hs00377633_m1 NM_000129 F13A1 Hs00173388_m1 288 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 BC006245 FGF18 Hs00818572_m1 NM_003862 FGF18 Hs00818572_m1 NM_003862 FGF18 Hs00818572_m1 U29538 FHL1 Hs00793641_g1 AF098518 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 AF063002 FHL1 Hs00793641_g1 NM_001449 FHL1 Hs00793641_g1 NM_203371 FIBIN Hs00831591_s1 NM_007270 FKBP9 Hs00414859_m1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_013231 FLRT2 Hs00544171_s1 NM_001460 FMO2 Hs00155158_m1 NM_032532 FNDC1 Hs00287359_m1 NM_001452 FOXF2 Hs00230963_m1 NM_005197 FOXN3 Hs00830558_g1 NM_005197 FOXN3 Hs00830558_g1 NM_002015 FOXO1 Hs00231106_m1 NM_001463 FRZB Hs00173503_m1 U91903 FRZB Hs00173503_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_000148 FUT1 Hs00355741_m1 NM_005031 FXYD1 Hs00245327_m1 NM_022003 FXYD6 Hs01121135_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 NM_000820 GAS6 Hs01090305_m1 L13720 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 289 BC006454 GAS7 Hs00932959_m1 NM_004962 GDF10 Hs01086867_m1 NM_005261 GEM Hs00738924_m1 NM_005110 GFPT2 Hs01049561_m1 NM_004121 GGT5 Hs00269779_m1 NM_005270 GLI2 Hs00257977_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_004126 GNG11 Hs00914578_m1 NM_053064 GNG2 Hs00828232_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_198827 GPR133 Hs00914797_m1 NM_002084 GPX3 Hs02513161_s1 NM_002084 GPX3 Hs02513161_s1 NM_000177 GSN Hs00388617_m1 NM_002101 GYPC Hs00242584_m1 NM_000601 HGF Hs00900066_m1 NM_031935 HMCN1 Hs00399043_m1 NM_052970 HSPA12B Hs00369554_m1 NM_001541 HSPB2 Hs00155436_m1 NM_144617 HSPB6 Hs00328933_m1 M85289 HSPG2 Hs01078536_m1 NM_000867 HTR2B Hs00168362_m1 NM_002167 ID3 Hs00171409_m1 NM_001546 ID4 Hs00155465_m1 NM_020962 IGDCC4 Hs00326335_m1 NM_000618 IGF1 Hs01547657_m1 NM_000618 IGF1 Hs01547657_m1 NM_001007139 IGF2 Hs00277496_s1 NM_002178 IGFBP6 Hs00942697_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_138284 IL17D Hs00370528_m1 AF128846 INMT Hs00198941_m1 NM_005545 ISLR Hs01921558_s1 AF072132 ITGA7 Hs00174397_m1 NM_002206 ITGA7 Hs00174397_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_030569 ITIH5 Hs00262393_s1 AF114488 ITSN1 Hs00161676_m1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_015493 KANK2 Hs00795260_m1 NM_138444 KCTD12 Hs00540818_s1 290 NM_018240 KIRREL Hs00217307_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002293 LAMC1 Hs00267056_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_001290 LDB2 Hs00609711_m1 U50748 LEPR Hs00900242_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_199000 LHFPL3 Hs01585188_s1 NM_017980 LIMS2 Hs01002880_gH NM_153713 LIX1L Hs00542269_m1 NM_012134 LMOD1 Hs00201704_m1 NM_005576 LOXL1 Hs00935937_m1 NM_020871 LRCH2 Hs00325819_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_005512 LRRC32 Hs00194136_m1 AF113211 LTBP2 Hs00544640_s1 NM_000428 LTBP2 Hs00544640_s1 NM_003573 LTBP4 Hs00186025_m1 NM_005584 MAB21L1 Hs00366575_s1 NM_032427 MAML2 Hs00418423_m1 NM_005924 MEOX2 Hs00232248_m1 NM_002404 MFAP4 Hs00412974_m1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 NM_024756 MMRN2 Hs00226971_m1 NM_002430 MN1 Hs00159202_m1 NM_024761 MOBKL2B Hs00257351_m1 NM_024761 MOBKL2B Hs00257351_m1 AY007239 MOXD1 Hs00378239_m1 NM_012219 MRAS Hs00327411_s1 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001008528 MXRA7 Hs00895155_m1 NM_001008528 MXRA7 Hs00895155_m1 NM_032348 MXRA8 Hs00260584_m1 NM_022844 MYH11 Hs00224622_m1 NM_006097 MYL9 Hs00697086_m1 NM_004538 NAP1L3 Hs00270173_s1 291 U35139 NDN Hs00267349_s1 NM_144573 NEXN Hs00332124_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_016533 NINJ2 Hs00356576_m1 NM_002514 NOV Hs00159631_m1 NM_002514 NOV Hs00159631_m1 NM_003995 NPR2 Hs00241516_m1 NM_005654 NR2F1 Hs00818842_m1 NM_016588 NRN1 Hs00213192_m1 NM_178507 OAF Hs00420156_m1 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_145260 OSR1 Hs00377071_m1 NM_016081 PALLD Hs01082959_m1 NM_019035 PCDH18 Hs00251855_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 NM_021630 PDLIM2 Hs00222154_m1 NM_021965 PGM5 Hs00222671_m1 NM_015157 PHLDB1 Hs00384827_m1 NM_017933 PID1 Hs00952182_m1 NM_000297 PKD2 Hs00165517_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_005032 PLS3 Hs00192406_m1 NM_020353 PLSCR4 Hs00924823_m1 NM_153703 PODN Hs00542259_m1 AF014403 PPAP2A Hs00170356_m1 AB000888 PPAP2A Hs00170356_m1 NM_003713 PPAP2B Hs00170359_m1 AF324888 PPP1R12B Hs00364082_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_145040 PRKCDBP Hs00293638_m1 292 NM_002742 PRKD1 Hs00177037_m1 NM_000313 PROS1 Hs00165590_m1 NM_006902 PRRX1 Hs00246569_m1 NM_000961 PTGIS Hs00919949_m1 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 NM_006775 QKI Hs00287641_m1 NM_006909 RASGRF2 Hs00394798_m1 NM_016563 RASL12 Hs00275429_m1 NM_021111 RECK Hs01019179_m1 AF186779 RGL1 Hs00248508_m1 AL136826 RGMA Hs03986139_s1 NM_020663 RHOJ Hs00368156_m1 NM_005012 ROR1 Hs00178178_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_153334 SCARF2 Hs00544847_m1 NM_002976 SCN7A Hs00161546_m1 U88870 SEPT4 Hs00910210_g1 NM_006216 SERPINE2 Hs00385730_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 AF311912 SFRP2 Hs00293258_m1 NM_003013 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 NM_001009555 SH3D19 Hs00296942_m1 NM_014631 SH3PXD2A Hs00206037_m1 AF055585 SLIT2 Hs00191193_m1 NM_004787 SLIT2 Hs00191193_m1 AB011538 SLIT3 Hs00171524_m1 NM_003062 SLIT3 Hs00171524_m1 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 NM_018013 SOBP Hs00215979_m1 NM_015385 SORBS1 Hs00908953_m1 NM_003118 SPARC Hs00277762_m1 NM_004684 SPARCL1 Hs00949881_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_005841 SPRY1 Hs01083036_s1 NM_006307 SRPX Hs00196867_m1 AL136756 SSPN Hs00296706_s1 293 NM_005086 SSPN Hs00296706_s1 NM_033025 SYDE1 Hs00263581_m1 NM_007286 SYNPO Hs00702468_s1 NM_133477 SYNPO2 Hs02786674_s1 NM_003186 TAGLN Hs00162558_m1 NM_015079 TBC1D2B Hs00534954_m1 NM_152380 TBX15 Hs00537087_m1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 BC001830 TGFB1I1 Hs00210887_m1 NM_003248 THBS4 Hs00170261_m1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 AB002318 TLN2 Hs00322257_m1 NM_018286 TMEM100 Hs00388033_m1 NM_024600 TMEM204 Hs01061927_m1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_012288 TRAM2 Hs00202213_m1 NM_173485 TSHZ2 Hs00251507_s1 AL136805 TSHZ3 Hs02379784_s1 NM_057179 TWIST2 Hs00382379_m1 NM_003380 VIM Hs00958116_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_015472 WWTR1 Hs00210007_m1 NM_015642 ZBTB20 Hs00210321_m1 NM_015642 ZBTB20 Hs00210321_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_024721 ZFHX4 Hs00257312_s1 NM_012082 ZFPM2 Hs00201397_m1 NM_015069 ZNF423 Hs00323880_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 PRKCDBP Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_001033583 ACOT9 Hs00202482_m1 NM_001613 ACTA2 Hs00426835_g1 M95178 ACTN1 Hs00998100_m1 BC003576 ACTN1 Hs00998100_m1 294 NM_001102 ACTN1 Hs00998100_m1 NM_000020 ACVRL1 Hs00163543_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_003474 ADAM12 Hs01106111_m1 NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_014244 ADAMTS2 Hs01040735_mH NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_007038 ADAMTS5 Hs00199841_m1 NM_197941 ADAMTS6 Hs00812159_s1 NM_015833 ADARB1 Hs00953724_m1 NM_001129 AEBP1 Hs00937468_m1 NM_006796 AFG3L2 Hs00255224_m1 NM_020133 AGPAT4 Hs00220031_m1 NM_005100 AKAP12 Hs00374507_m1 AB003476 AKAP12 Hs00374507_m1 NM_005465 AKT3 Hs00289302_s1 NM_005465 AKT3 Hs00289302_s1 NM_001034173 ALDH1L2 Hs00402876_m1 NM_130847 AMOTL1 Hs00294070_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_012098 ANGPTL2 Hs00765775_m1 NM_054027 ANKH Hs00219798_m1 NM_054027 ANKH Hs00219798_m1 NM_014942 ANKRD6 Hs00208902_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_018153 ANTXR1 Hs00216777_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_058172 ANTXR2 Hs00291622_m1 NM_000700 ANXA1 Hs00945401_m1 NM_153000 APCDD1 Hs00537787_m1 NM_022481 ARAP3 Hs00223903_m1 NM_001010000 ARHGAP28 Hs00229108_m1 NM_020754 ARHGAP31 Hs00393361_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_018071 ARHGEF40 Hs00216283_m1 NM_005737 ARL4C Hs00255039_s1 NM_000047 ARSE Hs01033722_m1 AF316824 ASPN Hs00214395_m1 NM_017680 ASPN Hs00214395_m1 295 NM_001007026 ATN1 Hs00157312_m1 NM_001699 AXL Hs01064444_m1 NM_021913 AXL Hs01064444_m1 NM_033309 B3GNT9 Hs00740919_g1 NM_012104 BACE1 Hs01123242_m1 AF095192 BAG2 Hs00188716_m1 NM_005504 BCAT1 Hs00298666_s1 NM_005504 BCAT1 Hs00298666_s1 NM_152731 BEND6 Hs00288163_m1 BC002416 BGN Hs00959143_m1 NM_001711 BGN Hs00959143_m1 NM_017614 BHMT2 Hs00214120_m1 NM_001199 BMP1 Hs00986789_m1 NM_006129 BMP1 Hs00196183_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_017637 BNC2 Hs00214187_m1 NM_033254 BOC Hs00264408_m1 NM_004334 BST1 Hs01070190_m1 AL136653 C10orf10 Hs00199735_m1 NM_022338 C11orf24 Hs01125237_m1 NM_020179 C11orf75 Hs00745008_s1 NM_014059 C13orf15 Hs00204129_m1 NM_032849 C13orf33 Hs00262558_m1 NM_030968 C1QTNF1 Hs00945123_m1 NM_030945 C1QTNF3 Hs00229569_m1 AF329841 C1QTNF5 Hs00363053_g1 AF329842 C1QTNF6 Hs00230464_m1 NM_001733 C1R Hs00354278_m1 M18767 C1S Hs01043795_m1 NM_004772 C5orf13 Hs00854282_g1 AF313413 C5orf62 Hs00383944_m1 NM_183373 C6orf145 Hs00406043_m1 NM_024728 C7orf10 Hs00257329_m1 NM_001013842 C8orf58 Hs00543616_m1 NM_032823 C9orf3 Hs01051467_m1 NM_004342 CALD1 Hs00921982_m1 NM_004342 CALD1 Hs00921982_m1 NM_015916 CALHM2 Hs00374996_m1 BC000039 CALHM2 Hs00374996_m1 AF356193 CARD6 Hs01123611_m1 NM_001753 CAV1 Hs00971716_m1 NM_001753 CAV1 Hs00971716_m1 NM_001233 CAV2 Hs00184597_m1 NM_001233 CAV2 Hs00184597_m1 296 AL136562 CCDC3 Hs00230222_m1 NM_032040 CCDC8 Hs00540204_s1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 NM_199511 CCDC80 Hs00736722_m1 AF245436 CCDC82 Hs00226834_m1 NM_016557 CCRL1 Hs00664347_s1 AF063591 CD200 Hs01033303_m1 NM_020404 CD248 Hs00535586_s1 NM_001024736 CD276 Hs00987207_m1 NM_012072 CD93 Hs00362607_m1 NM_002414 CD99 Hs00365982_m1 U82164 CD99 Hs00242853_m1 NM_002414 CD99 Hs00365982_m1 NM_145057 CDC42EP5 Hs01936746_s1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 D21254 CDH11 Hs00901475_m1 NM_001797 CDH11 Hs00901475_m1 NM_006561 CELF2 Hs00990166_m1 NM_016174 CERCAM Hs00170969_m1 NM_000186 CFH Hs00962366_m1 NM_000186 CFH Hs00962366_m1 NM_000204 CFI Hs00989715_m1 NM_018413 CHST11 Hs00218229_m1 NM_004273 CHST3 Hs01000045_m1 AB017915 CHST3 Hs01000045_m1 NM_175856 CHSY3 Hs00545664_m1 D86586 CLEC11A Hs00161544_m1 NM_002975 CLEC11A Hs00161544_m1 BC005810 CLEC11A Hs00161544_m1 BC005254 CLEC2B Hs00192860_m1 NM_013943 CLIC4 Hs00749895_s1 NM_015526 CLIP3 Hs00367493_m1 NM_024769 CLMP Hs00956750_m1 NM_024769 CLMP Hs00956750_m1 NM_144601 CMTM3 Hs00738855_m1 NM_001299 CNN1 Hs00154543_m1 NM_004368 CNN2 Hs00854264_s1 NM_015463 CNRIP1 Hs00384403_m1 NM_000493 COL10A1 Hs00166657_m1 NM_000493 COL10A1 Hs00166657_m1 NM_004370 COL12A1 Hs00329355_s1 NM_001855 COL15A1 Hs01559630_m1 297 NM_001856 COL16A1 Hs00156876_m1 NM_030582 COL18A1 Hs01043425_g1 AF018081 COL18A1 Hs01043425_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000088 COL1A1 Hs01076775_g1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000089 COL1A2 Hs01028971_m1 NM_000090 COL3A1 Hs00943809_m1 NM_000090 COL3A1 Hs00943809_m1 NM_001846 COL4A2 Hs01098873_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000093 COL5A1 Hs00609088_m1 NM_000393 COL5A2 Hs00893923_m1 NM_000393 COL5A2 Hs00893923_m1 NM_015719 COL5A3 Hs00210526_m1 NM_015719 COL5A3 Hs00210526_m1 NM_001848 COL6A1 Hs00242448_m1 NM_001848 COL6A1 Hs00242448_m1 AY029208 COL6A2 Hs00242484_m1 NM_001849 COL6A2 Hs00242484_m1 NM_004369 COL6A3 Hs00915120_m1 NM_001850 COL8A1 Hs00156669_m1 NM_005202 COL8A2 Hs00697025_m1 NM_005202 COL8A2 Hs00697025_m1 NM_000095 COMP Hs00164359_m1 NM_016429 COPZ2 Hs00212698_m1 NM_006587 CORIN Hs00198141_m1 NM_006587 CORIN Hs00198141_m1 NM_152727 CPNE2 Hs00541611_m1 NM_153634 CPNE8 Hs00402394_m1 NM_019609 CPXM1 Hs01566704_g1 BC006393 CPZ Hs00186333_m1 AL136861 CRISPLD2 Hs00230322_m1 AF007162 CRYAB Hs00157107_m1 U46006 CSRP2 Hs00426717_m1 NM_001321 CSRP2 Hs00426717_m1 NM_015235 CSTF2T Hs00915629_s1 M92934 CTGF Hs00170014_m1 NM_138455 CTHRC1 Hs00298917_m1 NM_001908 CTSB Hs00947439_m1 NM_000396 CTSK Hs00166156_m1 NM_000609 CXCL12 Hs00930455_m1 NM_000398 CYB5R3 Hs00240921_m1 298 NM_134268 CYGB Hs00370478_m1 NM_004227 CYTH3 Hs00188456_m1 BC003064 DAB2 Hs01120074_m1 AF188298 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_001343 DAB2 Hs01120074_m1 NM_016651 DACT1 Hs03987602_g1 NM_145056 DACT3 Hs00376818_m1 NM_173674 DCBLD1 Hs00920580_m1 NM_003737 DCHS1 Hs01044548_m1 AF138303 DCN Hs00266491_m1 AF138302 DCN Hs00370385_m1 NM_001920 DCN Hs00754870_s1 NM_001920 DCN Hs00754870_s1 NM_001014796 DDR2 Hs01025953_m1 NM_006182 DDR2 Hs01025953_m1 NM_001014796 DDR2 Hs01025953_m1 NM_139160 DEPDC7 Hs00373609_m1 NM_004403 DFNA5 Hs00189346_m1 NM_013253 DKK3 Hs00247429_m1 NM_001018057 DKK3 Hs00247429_m1 NM_006094 DLC1 Hs00183436_m1 NM_001005336 DNM1 Hs00189369_m1 NM_018431 DOK5 Hs00218324_m1 NM_001935 DPP4 Hs00175210_m1 NM_001937 DPT Hs00355056_m1 NM_001937 DPT Hs00355056_m1 NM_001386 DPYSL2 Hs00954558_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_001387 DPYSL3 Hs00181665_m1 NM_013352 DSE Hs00203441_m1 NM_001947 DUSP7 Hs00997002_m1 NM_014934 DZIP1 Hs00208790_m1 NM_014934 DZIP1 Hs00208790_m1 NM_024007 EBF1 Hs00395513_m1 NM_024007 EBF1 Hs00395513_m1 NM_001393 ECM2 Hs00154821_m1 NM_005711 EDIL3 Hs00174781_m1 NM_001957 EDNRA Hs03988672_m1 AB030655 EFEMP2 Hs00213545_m1 NM_016938 EFEMP2 Hs00213545_m1 NM_014601 EHD2 Hs00277504_m1 NM_014601 EHD2 Hs00277504_m1 NM_020390 EIF5A2 Hs00702673_s1 NM_020390 EIF5A2 Hs00702673_s1 299 NM_005230 ELK3 Hs00987814_m1 NM_000501 ELN Hs01091772_m1 NM_007046 EMILIN1 Hs00170878_m1 NM_001423 EMP1 Hs00608055_m1 NM_001423 EMP1 Hs00608055_m1 NM_001425 EMP3 Hs00171319_m1 NM_004098 EMX2 Hs00244574_m1 NM_000118 ENG Hs03986114_s1 NM_001776 ENTPD1 Hs00739960_s1 NM_001431 EPB41L2 Hs00154988_m1 NM_138961 ESAM Hs00332781_m1 NM_004956 ETV1 Hs00290469_s1 NM_004454 ETV5 Hs00231790_m1 NM_147127 EVC2 Hs00377633_m1 NM_000401 EXT2 Hs00181158_m1 NM_000129 F13A1 Hs00173388_m1 NM_182705 FAM101B Hs00823804_m1 NM_182705 FAM101B Hs00823804_m1 NM_032581 FAM126A Hs00261521_m1 NM_001010924 FAM171A1 Hs00295934_m1 NM_032181 FAM176A Hs00259924_m1 NM_020223 FAM20C Hs00398243_m1 NM_153711 FAM26E Hs00382139_m1 U76833 FAP Hs00990806_m1 NM_000043 FAS Hs00907759_m1 NM_000043 FAS Hs00907759_m1 NM_024582 FAT4 Hs00707110_s1 NM_001996 FBLN1 Hs00242546_m1 NM_006486 FBLN1 Hs00197774_m1 NM_001996 FBLN1 Hs00242546_m1 NM_001998 FBLN2 Hs00157482_m1 NM_006329 FBLN5 Hs00197064_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_000138 FBN1 Hs00171191_m1 NM_006832 FERMT2 Hs01041255_m1 Z24725 FERMT2 Hs01041255_m1 NM_005103 FEZ1 Hs00192714_m1 NM_000800 FGF1 Hs00265254_m1 NM_003862 FGF18 Hs00818572_m1 NM_001449 FHL1 Hs00793641_g1 NM_004468 FHL3 Hs00189516_m1 NM_025135 FHOD3 Hs00228447_m1 NM_203371 FIBIN Hs00831591_s1 NM_203371 FIBIN Hs00831591_s1 300 NM_014890 FILIP1L Hs00706279_s1 NM_017946 FKBP14 Hs00942521_m1 AF100751 FKBP7 Hs00535040_m1 NM_007270 FKBP9 Hs00414859_m1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_001456 FLNA Hs02558140_s1 NM_013231 FLRT2 Hs00544171_s1 NM_002021 FMO1 Hs00266654_m1 AF130095 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 NM_002026 FN1 Hs00415006_m1 BC005858 FN1 Hs00415006_m1 NM_032532 FNDC1 Hs00287359_m1 NM_022763 FNDC3B Hs00224289_m1 NM_022823 FNDC4 Hs00224502_m1 NM_001452 FOXF2 Hs00230963_m1 NM_002015 FOXO1 Hs00231106_m1 NM_003088 FSCN1 Hs00979631_g1 NM_013409 FST Hs00246256_m1 NM_006350 FST Hs00246260_m1 BC000055 FSTL1 Hs00907496_m1 NM_000148 FUT1 Hs00355741_m1 NM_022003 FXYD6 Hs01121135_m1 NM_003505 FZD1 Hs00268943_s1 NM_003507 FZD7 Hs00275833_s1 NM_024637 GAL3ST4 Hs00430693_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_054110 GALNTL2 Hs00365065_m1 NM_002048 GAS1 Hs00266715_s1 L13720 GAS6 Hs01090305_m1 NM_000820 GAS6 Hs01090305_m1 NM_003644 GAS7 Hs00932959_m1 BC001152 GAS7 Hs00932959_m1 BC006454 GAS7 Hs00932959_m1 NM_005110 GFPT2 Hs01049561_m1 NM_004121 GGT5 Hs00269779_m1 NM_005266 GJA5 Hs00270952_s1 M86849 GJB2 Hs00269615_s1 NM_012201 GLG1 Hs00953976_s1 NM_005270 GLI2 Hs00257977_m1 NM_006851 GLIPR1 Hs00199268_m1 NM_022343 GLIPR2 Hs00223508_m1 NM_022343 GLIPR2 Hs00223508_m1 NM_032575 GLIS2 Hs00402743_g1 301 NM_152629 GLIS3 Hs00295084_s1 NM_031302 GLT8D2 Hs00229917_m1 NM_031302 GLT8D2 Hs00229917_m1 NM_004126 GNG11 Hs00914578_m1 NM_053064 GNG2 Hs00828232_m1 NM_005708 GPC6 Hs00170677_m1 NM_001001994 GPM6B Hs01041077_m1 NM_032777 GPR124 Hs00262150_m1 NM_032777 GPR124 Hs00262150_m1 NM_007223 GPR176 Hs01064696_m1 NM_015696 GPX7 Hs00210410_m1 NM_001008397 GPX8 Hs00380670_m1 NM_013372 GREM1 Hs00171951_m1 NM_002091 GRP Hs00181852_m1 NM_000177 GSN Hs00388617_m1 AF200715 GULP1 Hs00169604_m1 NM_016315 GULP1 Hs00169604_m1 NM_002101 GYPC Hs00242584_m1 NR_002196 H19 Hs00262142_g1 NM_014799 HEPH Hs00953259_m1 NM_014571 HEYL Hs01113778_m1 NM_021958 HLX Hs00172035_m1 NM_031935 HMCN1 Hs00399043_m1 NM_000861 HRH1 Hs00911670_s1 NM_052970 HSPA12B Hs00369554_m1 NM_001541 HSPB2 Hs00155436_m1 M85289 HSPG2 Hs01078536_m1 NM_002775 HTRA1 Hs01016151_m1 NM_053044 HTRA3 Hs01099710_m1 NM_053044 HTRA3 Hs01099710_m1 NM_002167 ID3 Hs00171409_m1 BC002857 IFFO1 Hs00209967_m1 AF208043 IFI16 Hs00194261_m1 NM_005531 IFI16 Hs00986755_m1 NM_020962 IGDCC4 Hs00326335_m1 NM_001007139 IGF2 Hs00277496_s1 M31159 IGFBP3 Hs00181211_m1 NM_002178 IGFBP6 Hs00942697_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_001553 IGFBP7 Hs00944483_m1 NM_153687 IKBIP Hs00291515_m1 NM_004517 ILK Hs00177914_m1 NM_002192 INHBA Hs01081598_m1 M13436 INHBA Hs01081598_m1 NM_005545 ISLR Hs01921558_s1 302 AF109681 ITGA11 Hs01012939_m1 NM_002205 ITGA5 Hs01547673_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_004791 ITGBL1 Hs00191224_m1 NM_033397 ITPRIP Hs01878396_s1 NM_021219 JAM2 Hs01022013_m1 NM_032801 JAM3 Hs00262270_s1 NM_015493 KANK2 Hs00795260_m1 NM_181712 KANK4 Hs00400916_m1 AF153820 KCNJ2 Hs01876357_s1 AF160967 KCNMB4 Hs00205704_m1 NM_024089 KDELC1 Hs00607574_g1 NM_015074 KIF1B Hs00248321_m1 NM_018012 KIF26B Hs00215977_m1 BC001211 KIFC3 Hs00194304_m1 NM_018240 KIRREL Hs00217307_m1 NM_000426 LAMA2 Hs01124081_m1 NM_002290 LAMA4 Hs00935293_m1 M20206 LAMB1 Hs01055971_m1 NM_002291 LAMB1 Hs01055971_m1 NM_002293 LAMC1 Hs00267056_m1 NM_018357 LARP6 Hs00217969_m1 AF207547 LATS2 Hs00324396_m1 NM_014572 LATS2 Hs00324396_m1 NM_178834 LAYN Hs00379511_m1 NM_001290 LDB2 Hs00609711_m1 NM_022356 LEPRE1 Hs00223565_m1 NM_002305 LGALS1 Hs00355202_m1 NM_005780 LHFP Hs00172961_m1 NM_005780 LHFP Hs00172961_m1 NM_199000 LHFPL3 Hs01585188_s1 NM_004987 LIMS1 Hs00757864_m1 NM_017980 LIMS2 Hs01002880_gH NM_153713 LIX1L Hs00542269_m1 NM_005572 LMNA Hs01108898_g1 NM_012134 LMOD1 Hs00201704_m1 NM_002317 LOX Hs00942480_m1 NM_002317 LOX Hs00942480_m1 NM_005576 LOXL1 Hs00935937_m1 NM_002318 LOXL2 Hs00158757_m1 NM_020871 LRCH2 Hs00325819_m1 NM_002332 LRP1 Hs00233899_m1 NM_002332 LRP1 Hs00233899_m1 NM_130830 LRRC15 Hs00370056_s1 NM_005824 LRRC17 Hs00180581_m1 303 NM_005512 LRRC32 Hs00194136_m1 NM_000428 LTBP2 Hs00544640_s1 NM_002345 LUM Hs00158940_m1 NM_002345 LUM Hs00158940_m1 NM_033631 LUZP1 Hs00612276_m1 NM_033631 LUZP1 Hs00612276_m1 NM_021020 LZTS1 Hs00232762_m1 NM_005360 MAF Hs00193519_m1 NM_019066 MAGEL2 Hs00255922_s1 NM_032427 MAML2 Hs00418423_m1 NM_002373 MAP1A Hs00357973_m1 M64571 MAP4 Hs00159048_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_004834 MAP4K4 Hs00377415_m1 NM_004834 MAP4K4 Hs00377415_m1 BC004995 MARVELD1 Hs00230362_m1 M29277 MCAM Hs00920938_g1 AF089868 MCAM Hs00920938_g1 M28882 MCAM Hs00920938_g1 NM_017459 MFAP2 Hs01027737_m1 NM_002404 MFAP4 Hs00412974_m1 NM_003480 MFAP5 Hs00185803_m1 NM_003480 MFAP5 Hs00185803_m1 U37283 MFAP5 Hs00185803_m1 BC003610 MFGE8 Hs00170712_m1 NM_014632 MICAL2 Hs01121806_m1 NM_014632 MICAL2 Hs01121806_m1 NM_000248 MITF Hs01117294_m1 NM_000248 MITF Hs01117294_m1 NM_004995 MMP14 Hs01037009_g1 NM_004995 MMP14 Hs01037009_g1 U38321 MMP19 Hs00275699_m1 NM_004530 MMP2 Hs00234422_m1 NM_001032278 MMP28 Hs01020031_m1 NM_002430 MN1 Hs00159202_m1 NM_024761 MOBKL2B Hs00257351_m1 NM_024761 MOBKL2B Hs00257351_m1 NM_012219 MRAS Hs00327411_s1 NM_006039 MRC2 Hs00195862_m1 NM_145015 MRGPRF Hs01936726_s1 AF060154 MSC Hs00231955_m1 NM_002444 MSN Hs01085677_g1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 NM_001031679 MSRB3 Hs00827017_m1 304 AF245505 MXRA5 Hs00295630_s1 NM_001008528 MXRA7 Hs00895155_m1 NM_001008528 MXRA7 Hs00895155_m1 NM_032348 MXRA8 Hs00260584_m1 NM_006097 MYL9 Hs00697086_m1 NM_004998 MYO1E Hs00192232_m1 NM_005468 NAALADL1 Hs00193839_m1 NM_052867 NALCN Hs00291166_m1 NM_004538 NAP1L3 Hs00270173_s1 NM_005380 NBL1 Hs00185054_m1 NM_005380 NBL1 Hs00185054_m1 U35139 NDN Hs00267349_s1 NM_144573 NEXN Hs00332124_m1 NM_002508 NID1 Hs00159600_m1 NM_002508 NID1 Hs00159600_m1 NM_007361 NID2 Hs01547198_g1 NM_016533 NINJ2 Hs00356576_m1 NM_033120 NKD2 Hs00263909_m1 NM_001189 NKX3-2 Hs00154168_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_006169 NNMT Hs00196287_m1 NM_002514 NOV Hs00159631_m1 NM_016931 NOX4 Hs01558199_m1 NM_003995 NPR2 Hs00241516_m1 NM_016588 NRN1 Hs00213192_m1 NM_001024628 NRP1 Hs00826121_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_003872 NRP2 Hs01033058_m1 NM_002526 NT5E Hs01573922_m1 NM_002526 NT5E Hs01573922_m1 NM_016522 NTM Hs00275411_m1 NM_014840 NUAK1 Hs00934234_m1 NM_019094 NUDT4 Hs00819603_m1 NM_178507 OAF Hs00420156_m1 NM_014057 OGN Hs00247901_m1 NM_014057 OGN Hs00247901_m1 NM_198474 OLFML1 Hs00416948_m1 NM_015441 OLFML2B Hs00827139_g1 NM_020190 OLFML3 Hs00220180_m1 NM_005014 OMD Hs00192325_m1 NM_005014 OMD Hs00192325_m1 NM_182904 P4HA3 Hs00420085_m1 NM_016081 PALLD Hs01082959_m1 305 NM_016081 PALLD Hs01082959_m1 NM_000919 PAM Hs00168596_m1 NM_000919 PAM Hs00168596_m1 NM_002581 PAPPA Hs00545593_s1 NM_002581 PAPPA Hs00545593_s1 AF237771 PARVA Hs00217177_m1 NM_018222 PARVA Hs00217177_m1 NM_019035 PCDH18 Hs00251855_m1 NM_002589 PCDH7 Hs00159908_m1 AB006757 PCDH7 Hs00361092_m1 NM_002588 PCDHGC3 Hs00251717_m1 BC006439 PCDHGC3 Hs00251717_m1 NM_002593 PCOLCE Hs00170179_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_006200 PCSK5 Hs00196400_m1 NM_004716 PCSK7 Hs00237114_m1 NM_006206 PDGFRA Hs00998026_m1 NM_002609 PDGFRB Hs00387364_m1 NM_006207 PDGFRL Hs00185122_m1 NM_021630 PDLIM2 Hs00222154_m1 NM_005451 PDLIM7 Hs01103929_g1 NM_005451 PDLIM7 Hs01103929_g1 NM_001006624 PDPN Hs01089982_g1 NM_006474 PDPN Hs01089982_g1 NM_001006624 PDPN Hs01089982_g1 NM_003768 PEA15 Hs00273606_s1 BC001422 PGF Hs01119262_m1 NM_004427 PHC2 Hs00189460_m1 NM_015157 PHLDB1 Hs00384827_m1 M24779 PIM1 Hs01065498_m1 NM_000297 PKD2 Hs00165517_m1 NM_000929 PLA2G5 Hs00173472_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_006718 PLAGL1 Hs00414677_m1 NM_002656 PLAGL1 Hs00243030_m1 NM_002658 PLAU Hs00170182_m1 AY029180 PLAUR Hs00959822_m1 U08839 PLAUR Hs00182181_m1 NM_002667 PLN Hs00160179_m1 NM_000302 PLOD1 Hs00609368_m1 NM_005032 PLS3 Hs00192406_m1 NM_020360 PLSCR3 Hs00220521_m1 NM_020360 PLSCR3 Hs00220521_m1 306 NM_020353 PLSCR4 Hs00924823_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_020405 PLXDC1 Hs00220723_m1 NM_032812 PLXDC2 Hs00262350_m1 AL136663 PLXNA1 Hs00260134_s1 NM_005761 PLXNC1 Hs00955621_m1 NM_020182 PMEPA1 Hs03987603_g1 NM_020182 PMEPA1 Hs03987603_g1 NM_153703 PODN Hs00542259_m1 D13665 POSTN Hs01566750_m1 NM_001030059 PPAPDC1A Hs00404185_m1 BC006362 PPAPDC3 Hs00262043_m1 NM_000943 PPIC Hs00181460_m1 NM_014634 PPM1F Hs00206069_m1 NM_014634 PPM1F Hs00206069_m1 NM_002725 PRELP Hs00160431_m1 NM_002725 PRELP Hs00160431_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_153026 PRICKLE1 Hs01055551_m1 NM_002737 PRKCA Hs00925195_m1 NM_002742 PRKD1 Hs00177037_m1 NM_000311 PRNP Hs01920617_s1 NM_000313 PROS1 Hs00165590_m1 NM_024841 PRR5L Hs00757785_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_006902 PRRX1 Hs00246569_m1 NM_016307 PRRX2 Hs00212537_m1 NM_000961 PTGIS Hs00919949_m1 NM_002821 PTK7 Hs00897151_m1 NM_002839 PTPRD Hs00295441_s1 NM_002845 PTPRM Hs00267809_m1 AF312393 PTRF Hs00396859_m1 NM_012232 PTRF Hs00396859_m1 NM_006775 QKI Hs00287641_m1 NM_006775 QKI Hs00287641_m1 AF161486 RAB23 Hs00212407_m1 NM_016277 RAB23 Hs00212407_m1 NM_177403 RAB7B Hs00536338_s1 NM_015577 RAI14 Hs00210238_m1 BC000069 RARRES2 Hs00161209_g1 NM_007368 RASA3 Hs00183698_m1 NM_006909 RASGRF2 Hs00394798_m1 NM_002897 RBMS1 Hs00249930_s1 NM_002897 RBMS1 Hs00249930_s1 307 D28482 RBMS1 Hs00249930_s1 NM_005822 RCAN2 Hs00195165_m1 NM_001268 RCBTB2 Hs00154390_m1 NM_020650 RCN3 Hs00276633_m1 NM_020650 RCN3 Hs00276633_m1 NM_021111 RECK Hs01019179_m1 NM_144629 RFTN2 Hs00376096_m1 NM_021106 RGS3 Hs00367777_m1 NM_017821 RHBDL2 Hs00384848_m1 NM_020663 RHOJ Hs00368156_m1 NM_020663 RHOJ Hs00368156_m1 NM_024832 RIN3 Hs00227365_m1 NM_014746 RNF144A Hs00207267_m1 NM_019055 ROBO4 Hs00219408_m1 NM_005012 ROR1 Hs00178178_m1 NM_001006932 RPS6KA2 Hs00179731_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_004349 RUNX1T1 Hs00231702_m1 NM_001015051 RUNX2 Hs00298328_s1 NM_001015051 RUNX2 Hs00298328_s1 NM_002966 S100A10 Hs00751478_s1 NM_002961 S100A4 Hs00243202_m1 NM_153334 SCARF2 Hs00544847_m1 NM_014575 SCHIP1 Hs00205829_m1 NM_001006946 SDC1 Hs00896425_g1 NM_018243 SEPT11 Hs00217342_m1 NM_018243 SEPT11 Hs00217342_m1 U88870 SEPT4 Hs00910210_g1 NM_006216 SERPINE2 Hs00385730_m1 NM_002615 SERPINF1 Hs01106937_m1 NM_000062 SERPING1 Hs00934330_m1 NM_003013 SFRP2 Hs00293258_m1 AF311912 SFRP2 Hs00293258_m1 NM_003014 SFRP4 Hs00180066_m1 NM_003014 SFRP4 Hs00180066_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 NM_000337 SGCD Hs01087180_m1 AL136561 SGIP1 Hs00260297_m1 AF230904 SH3KBP1 Hs00230414_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_014631 SH3PXD2A Hs00206037_m1 NM_001017995 SH3PXD2B Hs00375183_s1 NM_006884 SHOX2 Hs01059691_m1 AF022654 SHOX2 Hs00243203_m1 308 AB023430 SIRPA Hs00757426_s1 NM_033518 SLC38A5 Hs01012028_m1 NM_152264 SLC39A13 Hs00378317_m1 NM_003062 SLIT3 Hs00171524_m1 NM_017575 SMG6 Hs00214019_m1 NM_017575 SMG6 Hs00214019_m1 NM_006932 SMTN Hs00199489_m1 AF064238 SMTN Hs00199489_m1 NM_003068 SNAI2 Hs00950344_m1 NM_018013 SOBP Hs00215979_m1 NM_020777 SORCS2 Hs00325181_m1 NM_003118 SPARC Hs00277762_m1 NM_003118 SPARC Hs00277762_m1 NM_015535 SPATS2L Hs00274702_m1 NM_021972 SPHK1 Hs00184211_m1 AF231124 SPOCK1 Hs00270274_m1 AB051390 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_006108 SPON1 Hs01120488_m1 NM_012445 SPON2 Hs00202813_m1 NM_025106 SPSB1 Hs00228304_m1 NM_025106 SPSB1 Hs00228304_m1 NM_006307 SRPX Hs00196867_m1 NM_014467 SRPX2 Hs00997580_m1 NM_005086 SSPN Hs00296706_s1 AL136756 SSPN Hs00296706_s1 NM_006927 ST3GAL2 Hs00199480_m1 NM_006927 ST3GAL2 Hs00199480_m1 NM_005418 ST5 Hs00936461_m1 NM_032528 ST6GAL2 Hs00290088_s1 NM_006873 STON1 Hs00538997_m1 NM_033025 SYDE1 Hs00263581_m1 NM_024893 SYNDIG1 Hs00227616_m1 NM_007286 SYNPO Hs00702468_s1 NM_080737 SYTL4 Hs00299039_m1 NM_003186 TAGLN Hs00162558_m1 NM_014604 TAX1BP3 Hs00205924_m1 AF234997 TAX1BP3 Hs00205924_m1 NM_152380 TBX15 Hs00537087_m1 NM_000192 TBX5 Hs00361155_m1 NM_152278 TCEAL7 Hs00385936_m1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 309 NM_003199 TCF4 Hs00972428_g1 NM_003199 TCF4 Hs00972428_g1 BC001830 TGFB1I1 Hs00210887_m1 NM_000358 TGFBI Hs03987596_s1 NM_003247 THBS2 Hs01568063_m1 NM_006288 THY1 Hs00264235_s1 AL161958 THY1 Hs00264235_s1 NM_006288 THY1 Hs00264235_s1 NM_005424 TIE1 Hs00892696_m1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 NM_003255 TIMP2 Hs01091319_m1 NM_000362 TIMP3 Hs00927216_m1 NM_007005 TLE4 Hs00276083_s1 NM_015444 TMEM158 Hs00374916_s1 NM_024600 TMEM204 Hs01061927_m1 AL136550 TMEM47 Hs00230190_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_007115 TNFAIP6 Hs01113602_m1 NM_003840 TNFRSF10D Hs00388742_m1 NM_001065 TNFRSF1A Hs00533568_g1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 BC000474 TP53I3 Hs00153280_m1 NM_003289 TPM2 Hs00268540_m1 NM_003596 TPST1 Hs00234324_m1 NM_012288 TRAM2 Hs00202213_m1 NM_003304 TRPC1 Hs00608195_m1 NM_003304 TRPC1 Hs00608195_m1 NM_020856 TSHZ3 Hs02379784_s1 AL136805 TSHZ3 Hs02379784_s1 NM_005725 TSPAN2 Hs00194836_m1 BC002654 TUBB6 Hs00603164_m1 NM_000474 TWIST1 Hs00361186_m1 NM_057179 TWIST2 Hs00382379_m1 AF322916 UACA Hs00326052_m1 NM_170744 UNC5B Hs00900710_m1 NM_170744 UNC5B Hs00900710_m1 NM_014909 VASH1 Hs00208609_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_004385 VCAN Hs01007944_m1 NM_014000 VCL Hs00243320_m1 U58111 VEGFC Hs01099206_m1 310 NM_016206 VGLL3 Hs00275109_s1 NM_016206 VGLL3 Hs00275109_s1 NM_003380 VIM Hs00958116_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_001031746 VSTM4 Hs00990862_m1 NM_021197 WFDC1 Hs00221849_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003882 WISP1 Hs00365573_m1 NM_003881 WISP2 Hs00180242_m1 NM_001002292 WLS Hs01553062_m1 NM_003391 WNT2 Hs00608224_m1 NM_015472 WWTR1 Hs00210007_m1 NM_145166 ZBTB47 Hs00908860_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_153367 ZCCHC24 Hs00380384_m1 NM_024721 ZFHX4 Hs00257312_s1 NM_012082 ZFPM2 Hs00201397_m1 NM_015069 ZNF423 Hs00323880_m1 NM_015461 ZNF521 Hs00296682_m1 NM_015461 ZNF521 Hs00296682_m1 NM_018181 ZNF532 Hs00539543_m1 NM_001010972 ZYX Hs00170299_m1 NM_003461 ZYX Hs00170299_m1 PSMC2 Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_004757 AIMP1 Hs00171131_m1 NM_007348 ATF6 Hs00232586_m1 NM_016468 COX16 Hs00212850_m1 NM_001412 EIF1AX Hs00796778_s1 NM_004487 GOLGB1 Hs00189566_m1 NM_002093 GSK3B Hs00275656_m1 D89678 HNRPDL Hs00943612_g1 NM_032622 LNX1 Hs00261754_m1 NM_020347 LZTFL1 Hs00220450_m1 NM_020191 MRPS22 Hs00220182_m1 NM_020191 MRPS22 Hs00220182_m1 NM_005023 PGGT1B Hs00941416_m1 NM_002647 PIK3C3 Hs00176908_m1 U03886 PNPLA4 Hs00378633_m1 NM_005105 RBM8A Hs00254802_s1 BC000232 REEP5 Hs00382478_m1 NM_006930 SKP1 Hs00749532_s1 311 NM_198999 SLC26A5 Hs01398267_m1 NM_003130 SRI Hs00234168_m1 RAB10 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_004300 ACP1 Hs00244706_g1 NM_004300 ACP1 Hs00244706_g1 NM_005722 ACTR2 Hs00855199_g1 NM_005721 ACTR3 Hs00828586_m1 NM_005721 ACTR3 Hs00828586_m1 NM_004504 AGFG1 Hs00427993_m1 NM_018685 ANLN Hs01120433_m1 NM_005744 ARIH1 Hs00194934_m1 NM_001177 ARL1 Hs01029870_m1 NM_018184 ARL8B Hs00750443_s1 BC003586 ARMC10 Hs00259089_m1 NM_030978 ARPC5L Hs00229649_m1 BC000018 ARPC5L Hs00229649_m1 AB028628 ASF1A Hs00204044_m1 NM_015459 ATL3 Hs00794490_m1 NM_001689 ATP5G3 Hs00266085_m1 NM_001689 ATP5G3 Hs00266085_m1 NM_016252 BIRC6 Hs00212288_m1 NM_001001342 BLOC1S2 Hs00611274_m1 NM_016401 C11orf73 Hs01581971_g1 NM_024738 C12orf49 Hs00226884_m1 NM_020375 C12orf5 Hs00608644_m1 AF061731 C14orf119 Hs00250466_m1 BC004818 C14orf129 Hs00212854_m1 NM_015609 C1orf144 Hs00379295_m1 AF274948 C20orf24 Hs00218951_m1 BC004446 C20orf24 Hs00218951_m1 NM_024520 C2orf47 Hs00225928_m1 BC004548 C2orf56 Hs00218600_m1 NM_173824 C3orf38 Hs00379322_m1 NM_001001701 C4orf3 Hs00386171_m1 AF116682 C6orf115 Hs00410715_m1 NM_152734 C6orf89 Hs00541641_m1 NM_138701 C7orf11 Hs00540849_m1 BC006110 C7orf70 Hs00801106_s1 NM_152523 CCNYL1 Hs00852689_s1 NM_152523 CCNYL1 Hs00852689_s1 NM_006016 CD164 Hs00985280_m1 NM_024529 CDC73 Hs00225998_m1 312 D88357 CDK1 Hs00364293_m1 NM_001809 CENPA Hs00903938_g1 NM_203463 CERS6 Hs00826756_m1 NM_001008708 CHAC2 Hs00378072_m1 NM_004804 CIAO1 Hs00191307_m1 NM_001008388 CISD2 Hs00381903_m1 NM_013943 CLIC4 Hs00749895_s1 AF112216 CMPK1 Hs01074420_g1 NM_152516 COMMD1 Hs00415059_m1 BC001228 COMMD2 Hs00211477_m1 AB047848 COPZ1 Hs00255433_m1 BC002342 CORO1C Hs00170938_m1 NM_006067 COX4NB Hs00196000_m1 NM_017437 CPSF2 Hs00298753_m1 NM_017437 CPSF2 Hs00298753_m1 NM_016207 CPSF3 Hs00211919_m1 NM_014171 CRIPT Hs00378194_m1 NM_014171 CRIPT Hs00378194_m1 AF241784 CRLS1 Hs00219512_m1 BC005299 CYCS Hs01588974_g1 NM_032486 DCTN5 Hs00739985_m1 NM_020640 DCUN1D1 Hs00603078_m1 BC004169 DCUN1D5 Hs00260376_m1 NM_003677 DENR Hs00795562_s1 BC001144 DNAJB11 Hs00212527_m1 NM_022552 DNMT3A Hs01027166_m1 NM_206831 DPH3 Hs00761040_s1 AF226998 DPY30 Hs00261491_m1 NM_001938 DR1 Hs00172424_m1 NM_001938 DR1 Hs00172424_m1 BC002809 DR1 Hs00172424_m1 NM_032331 ECE2 Hs04189541_g1 NM_004094 EIF2S1 Hs00612304_s1 AF047695 EIF4E2 Hs00601369_g1 AL080102 EIF5 Hs01028811_g1 NM_001969 EIF5 Hs01028811_g1 NM_033505 EPT1 Hs01013816_m1 NM_015701 ERLEC1 Hs00249026_m1 NM_014584 ERO1L Hs00205880_m1 NM_020728 ESYT2 Hs00294020_m1 NM_006544 EXOC5 Hs00272473_m1 NM_001014812 FAM96A Hs00607709_m1 NM_015475 FAM98A Hs00295622_m1 NM_012170 FBXO22 Hs00201796_m1 NM_012170 FBXO22 Hs00201796_m1 313 NM_015176 FBXO28 Hs00429691_m1 NM_022763 FNDC3B Hs00224289_m1 NM_007085 FSTL1 Hs00907496_m1 NM_001011537 FYTTD1 Hs00260265_m1 BC000973 G2E3 Hs00560314_m1 NM_012297 G3BP2 Hs00907696_m1 NM_002056 GFPT1 Hs00899865_m1 NM_002056 GFPT1 Hs00899865_m1 NM_000821 GGCX Hs00168139_m1 NM_016066 GLRX2 Hs00375015_m1 AF118652 GLRX3 Hs01582641_g1 BC005359 GMFB Hs00177752_m1 NM_002074 GNB1 Hs00181845_m1 AL136571 GOLT1B Hs01042467_m1 NM_016072 GOLT1B Hs01042467_m1 AB044661 GPN1 Hs00246735_m1 NM_138408 GTF3C6 Hs00431124_g1 NM_012412 H2AFV Hs00606542_mH NM_018097 HAUS2 Hs01077859_m1 NM_005333 HCCS Hs00193443_m1 AF255650 HIATL1 Hs00430874_m1 NM_138571 HINT3 Hs00370872_m1 NM_016185 HN1 Hs00602957_m1 NM_138394 HNRPLL Hs00293181_m1 NM_017813 IMPAD1 Hs01093068_m1 NM_020122 KCMF1 Hs01549125_m1 NM_006854 KDELR2 Hs00199277_m1 NM_002268 KPNA4 Hs00927639_g1 NM_002268 KPNA4 Hs00927639_g1 U93240 KPNA4 Hs00601211_m1 NM_001002257 LCLAT1 Hs00699427_m1 NM_152329 LRR1 Hs00907947_m1 NM_032121 MAGT1 Hs00794271_m1 NM_001006617 MAPKAP1 Hs00225549_m1 NM_032844 MASTL Hs00949171_m1 NM_139279 MCFD2 Hs00373767_m1 BC004183 MCMBP Hs00227371_m1 NM_014060 MCTS1 Hs00273873_m1 NM_005917 MDH1 Hs00936497_g1 NM_015955 MEMO1 Hs00831646_uH BC001396 METTL11A Hs00894565_m1 NM_145280 METTL21A Hs00697611_m1 NM_020194 MFF Hs00697397_m1 NM_032390 MKI67IP Hs00757500_s1 NM_015702 MMADHC Hs00948345_g1 314 NM_018221 MOBKL1B Hs00217172_m1 BC003398 MOBKL1B Hs00217172_m1 AF151853 MOBKL3 Hs00961389_g1 AF095727 MPZL1 Hs00827792_m1 NM_014763 MRPL19 Hs00608522_g1 NM_031903 MRPL32 Hs00388301_m1 NM_016622 MRPL35 Hs00424551_m1 NM_014050 MRPL42 Hs00204112_m1 NM_022915 MRPL44 Hs00224773_m1 NM_020409 MRPL47 Hs00415002_m1 NM_019051 MRPL50 Hs00745120_s1 NM_019051 MRPL50 Hs00745120_s1 NM_018141 MRPS10 Hs00216720_m1 NM_014342 MTCH2 Hs00819318_g1 NM_006636 MTHFD2 Hs00759197_s1 NM_025146 NAA50 Hs00363889_m1 NM_019080 NDFIP2 Hs00393276_m1 NM_005006 NDUFS1 Hs00192297_m1 NM_020726 NLN Hs00252959_m1 NM_015938 NMD3 Hs00274893_m1 NM_024894 NOL10 Hs00227621_m1 NM_002524 NRAS Hs00180035_m1 NM_007006 NUDT21 Hs00199656_m1 BC000025 NUDT5 Hs00274029_m1 NM_007172 NUP50 Hs00855432_g1 NM_138459 NUS1 Hs00604633_s1 NM_002577 PAK2 Hs02559219_s1 NM_152716 PATL1 Hs00405584_m1 NM_005742 PDIA6 Hs01012536_m1 NM_005742 PDIA6 Hs01012536_m1 BC001312 PDIA6 Hs01012536_m1 NM_005742 PDIA6 Hs01012536_m1 NM_002618 PEX13 Hs00159996_m1 NM_002629 PGAM1 Hs01652468_g1 NM_000291 PGK1 Hs00943178_g1 NM_018323 PI4K2B Hs00217854_m1 NM_020143 PNO1 Hs00220044_m1 NM_033109 PNPT1 Hs00396733_g1 BC003048 PPIL1 Hs00798372_s1 NM_006241 PPP1R2 Hs00761729_s1 NM_000945 PPP3R1 Hs01547793_m1 NM_174907 PPP4R2 Hs00752559_sH AF153607 PRELID1 Hs02638995_g1 NM_002790 PSMA5 Hs00936004_m1 NM_002816 PSMD12 Hs00738496_g1 315 NM_005805 PSMD14 Hs01113429_m1 NM_014614 PSME4 Hs00412002_m1 NM_001013663 PTRHD1 Hs00415546_m1 NM_033224 PURB Hs00328258_s1 AL136650 RAB10 Hs00794658_m1 BC000905 RAB1A Hs00800204_s1 NM_004161 RAB1A Hs00800204_s1 NM_004580 RAB27A Hs00608302_m1 NM_006861 RAB35 Hs00199284_m1 NM_016120 RLIM Hs00602952_m1 NM_022780 RMND5A Hs00405598_m1 NM_002936 RNASEH1 Hs00268000_m1 NM_173647 RNF149 Hs00411860_m1 NM_005156 ROD1 Hs01006008_g1 NM_006916 RPE Hs00851816_g1 NM_006916 RPE Hs00851816_g1 NM_006916 RPE Hs00851816_g1 NM_001034 RRM2 Hs01072069_g1 BC001886 RRM2 Hs01072069_g1 NM_033112 RRP36 Hs00384517_m1 NM_003729 RTCD1 Hs00186634_m1 NM_006054 RTN3 Hs00428645_m1 NM_020150 SAR1A Hs00833068_s1 NM_017988 SCYL2 Hs00250551_m1 AF346602 SEC61A1 Hs01037684_m1 NM_001013437 SEH1L Hs01031566_m1 AF184213 SF3B14 Hs00255423_m1 NM_145169 SFT2D1 Hs00376888_m1 NM_145169 SFT2D1 Hs00376888_m1 AF257318 SH3GLB1 Hs00211220_m1 AF263293 SH3GLB1 Hs00211220_m1 NM_003028 SHB Hs00295223_s1 BC004991 SLC25A33 Hs00757629_s1 NM_017964 SLC30A6 Hs00215827_m1 NM_017964 SLC30A6 Hs00215827_m1 NM_025181 SLC35F5 Hs00228615_m1 NM_018158 SLC4A1AP Hs00250835_m1 NM_016045 SLMO2 Hs00429845_m1 NM_006444 SMC2 Hs00197593_m1 NM_020463 SMEK2 Hs00383278_m1 BC006215 SMEK2 Hs00383284_m1 NM_006857 SNRNP27 Hs00386296_m1 NM_003096 SNRPG Hs01923241_g1 AF121856 SNX6 Hs00276682_m1 NM_021928 SPCS3 Hs00222513_m1 316 AL136660 SPCS3 Hs00222513_m1 NM_032802 SPPL2A Hs00607726_mH NM_021203 SRPRB Hs00253639_m1 NM_003144 SSR1 Hs00162340_m1 NM_003144 SSR1 Hs00162340_m1 NM_007107 SSR3 Hs00606481_m1 NM_005843 STAM2 Hs00195241_m1 NM_006463 STAMBP Hs00197726_m1 BC003074 STARD3NL Hs01106499_m1 NM_003162 STRN Hs01005318_m1 NM_003162 STRN Hs01005318_m1 NM_033161 SURF4 Hs00369130_m1 AF078866 SURF4 Hs00369130_m1 NM_006372 SYNCRIP Hs00749309_s1 AF151073 TBC1D7 Hs00212898_m1 BC001622 THUMPD3 Hs00356788_m1 NM_006327 TIMM23 Hs00197056_m1 NM_006327 TIMM23 Hs00197056_m1 NM_006327 TIMM23 Hs00197056_m1 NM_020123 TM9SF3 Hs00219998_m1 NM_016040 TMED5 Hs00211349_m1 AL136941 TMEM126A Hs00945042_m1 NM_145254 TMEM170A Hs00377057_m1 NM_018247 TMEM30A Hs00217382_m1 BC000948 TMEM33 Hs01027901_m1 NM_018266 TMEM39A Hs00217530_m1 NM_014313 TMEM50A Hs00900635_m1 NM_002270 TNPO1 Hs00541872_g1 NM_033550 TP53RK Hs00369266_m1 NM_052965 TSEN15 Hs00379071_m1 NM_004622 TSN Hs00172824_m1 NM_173810 TTC9C Hs00381854_m1 BC006405 TXNDC17 Hs00608858_m1 NM_005783 TXNDC9 Hs00195063_m1 NM_003336 UBE2A Hs00163308_m1 NM_003340 UBE2D3 Hs00701790_s1 NM_080678 UBE2F Hs01592406_m1 NM_080678 UBE2F Hs01592406_m1 NM_080678 UBE2F Hs01592406_m1 AF161502 UBE2J1 Hs00935350_m1 NM_003348 UBE2N Hs00854751_s1 AB032931 UBE2T Hs00204359_m1 NM_001001481 UBE2W Hs00217672_m1 AL136643 UBQLN1 Hs00923840_m1 NM_013438 UBQLN1 Hs00923840_m1 317 AF201946 VPS29 Hs01110749_m1 BC005937 VTA1 Hs00212881_m1 NM_016485 VTA1 Hs00212881_m1 NM_017588 WDR5 Hs00424605_m1 BC004875 YIPF4 Hs00260445_m1 NM_006555 YKT6 Hs00559914_m1 NM_014263 YME1L1 Hs00907919_m1 NM_006826 YWHAQ Hs00863277_g1 NM_178547 ZBTB8OS Hs00703935_s1 SF3A1 Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') AF119662 ATXN10 Hs00203028_m1 NM_014306 C22orf28 Hs00204783_m1 NM_033318 C22orf32 Hs00536438_m1 NM_005137 DGCR2 Hs00192970_m1 NM_003753 EIF3D Hs00388727_m1 NM_016091 EIF3L Hs01066348_g1 NM_019843 EIF4ENIF1 Hs01046371_g1 NM_001429 EP300 Hs00914223_m1 AL136553 LDOC1L Hs00707651_s1 NM_021090 MTMR3 Hs00328784_s1 NM_016418 NF2 Hs00738978_m1 U24223 PCBP1 Hs00362410_s1 NM_032311 POLDIP3 Hs00276880_s1 NM_152267 RNF185 Hs00270886_s1 NM_004630 SF1 Hs00190309_m1 NM_001005409 SF3A1 Hs01066327_m1 NM_005877 SF3A1 Hs01066327_m1 NM_001005409 SF3A1 Hs01066327_m1 D28588 SP2 Hs00175262_m1 NM_003932 ST13 Hs00832556_sH NM_016272 TOB2 Hs00249392_s1 SOD3 Número de acceso Símbolo (GenBank) del gen TaqMan®Assay (extremo 3') NM_003734 AOC3 Hs00186647_m1 NM_005161 APLNR Hs00270873_s1 NM_001170 AQP7 Hs00357359_m1 NM_022481 ARAP3 Hs00223903_m1 NM_032827 ATOH8 Hs00262454_m1 AF043899 BIN1 Hs00184913_m1 AF001383 BIN1 Hs00184913_m1 318 NM_004305 BIN1 Hs00184913_m1 NM_033254 BOC Hs00264408_m1 AY027658 BOC Hs00264408_m1 AL136653 C10orf10 Hs00199735_m1 NM_022153 C10orf54 Hs00735289_m1 NM_022153 C10orf54 Hs00735289_m1 NM_030968 C1QTNF1 Hs00945123_m1 NM_000587 C7 Hs00175109_m1 AL136562 CCDC3 Hs00230222_m1 M81104 CD34 Hs00990735_m1 NM_001795 CDH5 Hs00901463_m1 NM_145234 CHRDL1 Hs00292767_m1 NM_004273 CHST3 Hs01000045_m1 NM_022094 CIDEC Hs00535723_m1 NM_003277 CLDN5 Hs00533949_s1 NM_175060 CLEC14A Hs00545534_s1 AF007162 CRYAB Hs00157107_m1 NM_024689 CXorf36 Hs00226702_m1 NM_000398 CYB5R3 Hs00240921_m1 NM_134268 CYGB Hs00370478_m1 NM_052954 CYYR1 Hs00364793_m1 NM_002036 DARC Hs01011079_s1 NM_004944 DNASE1L3 Hs00172840_m1 NM_001005463 EBF3 Hs00291943_s1 NM_000118 ENG Hs03986114_s1 L35594 ENPP2 Hs00196470_m1 NM_138961 ESAM Hs00332781_m1 NM_007177 FAM107A Hs00200376_m1 AL050264 FAM107A Hs00200376_m1 NM_022823 FNDC4 Hs00224502_m1 NM_005031 FXYD1 Hs00245327_m1 NM_004962 GDF10 Hs01086867_m1 NM_005276 GPD1 Hs00193386_m1 NM_178172 GPIHBP1 Hs00417223_g1 NM_138445 GPR146 Hs00298904_s1 NM_002084 GPX3 Hs02513161_s1 NM_002084 GPX3 Hs02513161_s1 NM_024869 GRRP1 Hs00227532_m1 NM_000177 GSN Hs00388617_m1 NM_002101 GYPC Hs00242584_m1 NM_001541 HSPB2 Hs00155436_m1 NM_144617 HSPB6 Hs00328933_m1 NM_144617 HSPB6 Hs00328933_m1 NM_014424 HSPB7 Hs00205296_m1 NM_000873 ICAM2 Hs00168384_m1 319 NM_000873 ICAM2 Hs00168384_m1 NM_004512 IL11RA Hs00234415_m1 AF128846 INMT Hs00198941_m1 AF072132 ITGA7 Hs00174397_m1 NM_002206 ITGA7 Hs00174397_m1 NM_030569 ITIH5 Hs00262393_s1 NM_198471 KANK3 Hs00418312_m1 NM_014079 KLF15 Hs00362736_m1 NM_139284 LGI4 Hs00373801_m1 NM_017980 LIMS2 Hs01002880_gH NM_005357 LIPE Hs00943410_m1 NM_003573 LTBP4 Hs00186025_m1 BC002796 LYL1 Hs00245789_m1 BC003179 MALL Hs00193728_m1 M28882 MCAM Hs00920938_g1 AF089868 MCAM Hs00920938_g1 NM_004527 MEOX1 Hs00244943_m1 NM_002404 MFAP4 Hs00412974_m1 NM_002405 MFNG Hs00159117_m1 NM_024756 MMRN2 Hs00226971_m1 NM_024756 MMRN2 Hs00226971_m1 NM_205853 MUSTN1 Hs01592115_g1 NM_014520 MYBBP1A Hs00185208_m1 NM_022844 MYH11 Hs00224622_m1 NM_002507 NGFR Hs00182120_m1 NM_000906 NPR1 Hs00181445_m1 NM_000906 NPR1 Hs00181445_m1 NM_178507 OAF Hs00420156_m1 NM_002599 PDE2A Hs01042255_m1 NM_014759 PHYHIP Hs00901974_m1 NM_001012973 PLAC9 Hs00418288_m1 NM_020360 PLSCR3 Hs00220521_m1 AF326591 PLVAP Hs00229941_m1 NM_014634 PPM1F Hs00206069_m1 NM_014634 PPM1F Hs00206069_m1 NM_006741 PPP1R1A Hs00410058_m1 NM_002725 PRELP Hs00160431_m1 NM_016563 RASL12 Hs00275429_m1 U43559 RDH5 Hs00161263_m1 AL136826 RGMA Hs03986139_s1 NM_019055 ROBO4 Hs00219408_m1 NM_001400 S1PR1 Hs01922614_s1 NM_000331 SAA1 Hs00761940_s1 NM_173833 SCARA5 Hs01073151_m1 NM_173833 SCARA5 Hs01073151_m1 320 NM_003005 SELP Hs00356351_m1 NM_005489 SH2D3C Hs01552509_m1 AB011538 SLIT3 Hs00171524_m1 NM_017575 SMG6 Hs00214019_m1 NM_022454 SOX17 Hs00751752_s1 NM_015374 SUN2 Hs00391455_m1 NM_007286 SYNPO Hs00702468_s1 NM_007162 TFEB Hs00292981_m1 NM_005424 TIE1 Hs00892696_m1 NM_022648 TNS1 Hs00917032_m1 NM_022648 TNS1 Hs00917032_m1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_019105 TNXB Hs00372889_g1 NM_004615 TSPAN7 Hs00190284_m1 NM_000552 VWF Hs00169795_m1 SRRM2 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_181806 AASDH Hs00699243_m1 NM_025220 ADAM33 Hs00296426_m1 NM_015339 ADNP Hs00209721_m1 NM_005935 AFF1 Hs00610550_m1 NM_005935 AFF1 Hs00610550_m1 NM_014914 AGAP1 Hs00274576_m1 NM_006738 AKAP13 Hs00331658_s1 NM_006738 AKAP13 Hs00331658_s1 NM_006738 AKAP13 Hs00331658_s1 NM_006738 AKAP13 Hs00331658_s1 NM_015120 ALMS1 Hs01064641_m1 NM_025144 ALPK1 Hs00325918_m1 NM_173473 ANAPC16 Hs00383931_m1 NM_016237 ANAPC5 Hs01102438_m1 NM_017664 ANKRD10 Hs00214321_m1 NM_013275 ANKRD11 Hs00331872_s1 NM_015208 ANKRD12 Hs00209530_m1 NM_015208 ANKRD12 Hs00209530_m1 NM_015208 ANKRD12 Hs00209530_m1 NM_033121 ANKRD13A Hs00395421_m1 NM_025190 ANKRD36B Hs00414889_m1 NM_015245 ANKS1A Hs01040689_m1 NM_006305 ANP32A Hs00829953_g1 NM_006305 ANP32A Hs00829953_g1 NM_001003954 ANXA13 Hs00188802_m1 321 NM_003938 AP3D1 Hs00187577_m1 NM_000038 APC Hs01568270_m1 NM_000038 APC Hs01568270_m1 NM_018171 APPL2 Hs01565861_m1 NM_015313 ARHGEF12 Hs00209661_m1 NM_005744 ARIH1 Hs00194934_m1 NM_014154 ARMC8 Hs00204280_m1 NM_018489 ASH1L Hs00218516_m1 NM_006856 ATF7 Hs00232499_m1 NM_018179 ATF7IP Hs00216895_m1 NM_017974 ATG16L1 Hs00368834_m1 NM_033388 ATG16L2 Hs00400565_m1 NM_022374 ATL2 Hs00608716_m1 NM_005603 ATP8B1 Hs00900656_m1 NM_000489 ATRX Hs00997525_m1 NM_002973 ATXN2 Hs00268077_m1 NM_013449 BAZ2A Hs00203782_m1 NM_020235 BBX Hs00220317_m1 NM_020235 BBX Hs00220317_m1 NM_016252 BIRC6 Hs00212288_m1 NM_148894 BOD1L Hs00386037_m1 NM_004459 BPTF Hs00925866_m1 NM_005104 BRD2 Hs01121986_g1 NM_005104 BRD2 Hs01121986_g1 NM_014299 BRD4 Hs00204762_m1 NM_014299 BRD4 Hs00204762_m1 NM_152733 BTBD9 Hs00298028_s1 NM_153810 C10orf46 Hs00403870_m1 NM_024631 C11orf61 Hs00226408_m1 NM_017926 C14orf118 Hs00250472_m1 NM_004772 C5orf13 Hs00854282_g1 NM_024941 C5orf44 Hs00227853_m1 NM_198097 C7orf28B Hs00276365_m1 NM_032823 C9orf3 Hs01051467_m1 NM_000720 CACNA1D Hs00167753_m1 NM_001743 CALM2 Hs00830212_s1 NM_006136 CAPZA2 Hs00255135_m1 NM_024110 CARD14 Hs00364499_m1 NM_018237 CCAR1 Hs00603006_m1 NM_018237 CCAR1 Hs00603006_m1 NM_001008661 CCBL2 Hs00219725_m1 NM_019083 CCDC76 Hs00219487_m1 NM_001240 CCNT1 Hs00171029_m1 NM_003607 CDC42BPA Hs00207976_m1 NM_020239 CDC42SE1 Hs00970458_m1 322 NM_024529 CDC73 Hs00225998_m1 NM_003718 CDK13 Hs00243534_m1 NM_002595 CDK17 Hs00176839_m1 NM_002595 CDK17 Hs00176839_m1 NM_014704 CEP104 Hs00206793_m1 AF317887 CEP290 Hs00228353_m1 NM_014810 CEP350 Hs00207805_m1 NM_025180 CEP63 Hs00375588_m1 NM_001271 CHD2 Hs00172280_m1 NM_001271 CHD2 Hs00172280_m1 NM_001273 CHD4 Hs00172349_m1 NM_015226 CLEC16A Hs00389799_m1 NM_020666 CLK4 Hs00252917_m1 NM_018686 CMAS Hs00218814_m1 NM_138809 CMBL Hs00540853_m1 NM_182523 CMC1 Hs00699369_m1 NM_178868 CMTM8 Hs00418242_m1 NM_014515 CNOT2 Hs00248093_m1 NM_014515 CNOT2 Hs00248093_m1 NM_007018 CNTRL Hs00199723_m1 NM_005713 COL4A3BP Hs00178615_m1 NM_030627 CPEB4 Hs00286741_m1 NM_019095 CRLS1 Hs00219512_m1 NM_001025105 CSNK1A1 Hs00793391_m1 NM_024790 CSPP1 Hs00227161_m1 NM_001903 CTNNA1 Hs00944792_mH NM_001331 CTNND1 Hs00609738_g1 NM_001008895 CUL4A Hs00757716_m1 NM_001918 DBT Hs00157226_m1 NM_024345 DCAF10 Hs00995044_m1 NM_006386 DDX17 Hs00428757_m1 NM_006386 DDX17 Hs00428757_m1 NM_020414 DDX24 Hs00252691_m1 NM_022779 DDX31 Hs01077341_m1 NM_004640 DDX39B Hs00366447_m1 AL136611 DDX59 Hs00229936_m1 NM_024901 DENND2D Hs00227687_m1 NM_003677 DENR Hs00795562_s1 NM_003677 DENR Hs00795562_s1 NM_015954 DERA Hs00211032_m1 NM_030621 DICER1 Hs00998582_g1 NM_015151 DIP2A Hs00396274_m1 NM_014902 DLGAP4 Hs01582307_m1 NM_001031723 DNAJB14 Hs00368747_m1 NM_005223 DNASE1 Hs00173736_m1 323 NM_001376 DYNC1H1 Hs00378891_m1 U16797 EFNB2 Hs00187950_m1 NM_024852 EIF2C3 Hs01087121_m1 NM_003752 EIF3C Hs00186742_m1 NM_019843 EIF4ENIF1 Hs01046371_g1 NM_172373 ELF1 Hs00381199_m1 NM_006874 ELF2 Hs00959418_g1 NM_012081 ELL2 Hs00831747_s1 AF010314 ENC1 Hs00171580_m1 NM_015409 EP400 Hs00367471_m1 NM_001431 EPB41L2 Hs00154988_m1 NM_021235 EPS15L1 Hs00221980_m1 NM_016649 ESF1 Hs00363154_m1 NM_018638 ETNK1 Hs00218609_m1 NM_001987 ETV6 Hs01045747_m1 NM_016337 EVL Hs00275226_m1 NM_014613 FAF2 Hs00385091_m1 NM_014719 FAM115A Hs00206993_m1 NM_014612 FAM120A Hs00205966_m1 AL136630 FAM172A Hs00230742_m1 NM_018379 FAM63A Hs00930861_g1 NM_014808 FARP2 Hs00207771_m1 NM_012158 FBXL3 Hs01045265_m1 NM_012174 FBXW8 Hs00395481_m1 NM_006832 FERMT2 Hs01041255_m1 AK024388 FGFR1 Hs00259959_s1 NM_015308 FNBP4 Hs01553131_m1 NM_001012505 FOXP1 Hs00415004_m1 NM_001012505 FOXP1 Hs00415004_m1 NM_001012505 FOXP1 Hs00415004_m1 NM_001012505 FOXP1 Hs00415004_m1 NM_003902 FUBP1 Hs00231632_m1 NM_002039 GAB1 Hs00157646_m1 NM_002040 GABPA Hs00745591_s1 NM_003644 GAS7 Hs00932959_m1 NM_012201 GLG1 Hs00953976_s1 NM_004486 GOLGA2 Hs00366395_m1 NM_002078 GOLGA4 Hs00157775_m1 NM_001023567 GOLGA8B Hs00367259_m1 NM_014498 GOLIM4 Hs00274320_m1 NM_001002909 GPATCH8 Hs00323292_s1 NM_000408 GPD2 Hs01090711_m1 NM_001516 GTF2H3 Hs00956783_g1 NM_001518 GTF2I Hs00231018_m1 NM_004893 H2AFY Hs00191689_m1 324 NM_018097 HAUS2 Hs01077859_m1 NM_015382 HECTD1 Hs00383290_g1 NM_152696 HIPK1 Hs00323583_m1 NM_024503 HIVEP3 Hs00225836_m1 NM_001003810 HNRNPD Hs01086914_g1 NM_001003810 HNRNPD Hs01086914_g1 NM_001003810 HNRNPD Hs01086914_g1 NM_005968 HNRNPM Hs00246018_m1 NM_006896 HOXA7 Hs00600844_m1 NM_016245 HSD17B11 Hs00212226_m1 AF050145 IDS Hs01064295_m1 NM_000416 IFNGR1 Hs00988304_m1 NM_006531 IFT88 Hs00197926_m1 NM_002184 IL6ST Hs00174360_m1 NM_003866 INPP4B Hs00182580_m1 NM_033547 INTS4 Hs00417075_m1 NM_004136 IREB2 Hs00386293_m1 NM_002210 ITGAV Hs00233808_m1 AK024887 ITPK1-AS1 Hs01053867_s1 NM_012308 KDM2A Hs00367034_m1 NM_015015 KDM4B Hs00943636_m1 NM_015015 KDM4B Hs00943636_m1 NM_015061 KDM4C Hs00323906_m1 BC000717 KHDRBS1 Hs00173141_m1 NM_014802 KIAA0528 Hs00390363_m1 NM_001009814 KIAA0564 Hs00323369_m1 NM_014949 KIAA0907 Hs00208991_m1 NM_019590 KIAA1217 Hs00289569_m1 NM_015443 KIAA1267 Hs00393805_m1 NM_019600 KIAA1370 Hs00325311_m1 NM_005552 KLC1 Hs00194316_m1 NM_001206 KLF9 Hs00230918_m1 NM_020782 KLHDC5 Hs00325227_m1 NM_017644 KLHL24 Hs00214210_m1 NM_004985 KRAS Hs00270666_m1 NM_182926 KTN1 Hs00192160_m1 NR_002473 LOC440354 Hs00403469_m1 NM_005578 LPP Hs00194400_m1 NM_015116 LRCH1 Hs00996581_m1 NM_017768 LRRC40 Hs00214930_m1 NM_004735 LRRFIP1 Hs00190993_m1 NM_004735 LRRFIP1 Hs00190993_m1 NM_006309 LRRFIP2 Hs00196889_m1 NM_018385 LSG1 Hs00251109_m1 NM_015578 LSM14A Hs00385941_m1 325 NM_015565 LTN1 Hs00391630_m1 NM_006107 LUC7L3 Hs00212659_m1 NM_005885 MARCH6 Hs00195391_m1 NM_138441 MB21D1 Hs00403553_m1 NM_021038 MBNL1 Hs00253287_m1 NM_022132 MCCC2 Hs00223257_m1 NM_005587 MEF2A Hs01050409_m1 NM_001410 MEGF8 Hs00604376_s1 NM_006838 METAP2 Hs01127366_m1 NM_016025 METTL9 Hs00367590_m1 NM_024311 MFSD11 Hs00225636_m1 NM_012214 MGAT4A Hs00923405_m1 NM_020774 MIB1 Hs00379185_m1 NM_013255 MKLN1 Hs00183783_m1 BC000371 MLEC Hs00207082_m1 NM_005933 MLL Hs00610538_m1 NM_005933 MLL Hs00610538_m1 NM_005933 MLL Hs00610538_m1 AF067804 MLL5 Hs00218773_m1 NM_015026 MON2 Hs00736767_m1 NM_012286 MORF4L2 Hs00202211_m1 NM_017520 MPHOSPH8 Hs00736882_m1 NM_015134 MPRIP Hs00819388_m1 NM_032853 MUM1 Hs00536092_s1 BC002713 MXD4 Hs01598209_g1 NM_005964 MYH10 Hs00292551_m1 NM_033375 MYO1C Hs00300761_m1 NM_004999 MYO6 Hs01568222_m1 NM_013451 MYOF Hs03987599_u1 NM_025029 MZT2B Hs01656193_gH NM_025146 NAA50 Hs00363889_m1 NM_002482 NASP Hs00267329_m1 NM_020443 NAV1 Hs00368110_m1 NM_006540 NCOA2 Hs00896106_m1 NM_020967 NCOA5 Hs00253115_m1 NM_006311 NCOR1 Hs00196920_m1 NM_002496 NDUFS8 Hs00159597_m1 NM_002498 NEK3 Hs00300928_m1 NM_032815 NFATC2IP Hs00374014_g1 NM_005597 NFIC Hs00232157_m1 NM_005597 NFIC Hs00232157_m1 NM_015384 NIPBL Hs00209846_m1 NM_020726 NLN Hs00252959_m1 NM_006985 NPIP Hs00276063_m1 NM_012428 NPTN Hs01033358_m1 326 NM_021005 NR2F2 Hs00819630_m1 NM_002525 NRD1 Hs00895350_m1 NM_182543 NSUN6 Hs00400181_m1 NM_022731 NUCKS1 Hs01068059_g1 NM_006185 NUMA1 Hs00272062_m1 NM_001005743 NUMB Hs00269398_s1 NM_001008564 NUPL1 Hs00207510_m1 NM_017830 OCIAD1 Hs00215197_m1 NM_024586 OSBPL9 Hs00541027_m1 NM_020205 OTUD7B Hs00220240_m1 NM_175854 PAN3 Hs00545663_m1 NM_175854 PAN3 Hs00545663_m1 NM_175854 PAN3 Hs00545663_m1 NM_173797 PAPD4 Hs00406243_m1 NM_173797 PAPD4 Hs00406243_m1 NM_173797 PAPD4 Hs00406243_m1 NM_002585 PBX1 Hs00295499_s1 NM_002585 PBX1 Hs00295499_s1 NM_005016 PCBP2 Hs00245320_m1 NM_005016 PCBP2 Hs00245320_m1 NM_006315 PCGF3 Hs00602402_s1 NM_013232 PDCD6 Hs00202985_m1 NM_013232 PDCD6 Hs00202985_m1 NM_013232 PDCD6 Hs00202985_m1 NM_000923 PDE4C Hs00971857_mH NM_016205 PDGFC Hs00211916_m1 NM_002613 PDPK1 Hs00176884_m1 NM_015027 PDXDC1 Hs00415811_m1 NM_002632 PGF Hs01119262_m1 NM_015153 PHF3 Hs00209480_m1 NM_001008660 PICALM Hs00999731_g1 NM_181504 PIK3R1 Hs00933163_m1 NM_181504 PIK3R1 Hs00933163_m1 NM_012399 PITPNB Hs00273460_m1 NM_000296 PKD1 Hs00165489_m1 NM_006256 PKN2 Hs00178944_m1 NM_001005476 PKP4 Hs00269305_m1 NM_001005476 PKP4 Hs00269305_m1 NM_019012 PLEKHA5 Hs00219251_m1 NM_032870 PNISR Hs00369090_m1 NM_032870 PNISR Hs00369090_m1 NM_032870 PNISR Hs00369090_m1 NM_019014 POLR1B Hs00219263_m1 NM_003711 PPAP2A Hs00170356_m1 NM_003622 PPFIBP1 Hs00186240_m1 327 NM_003622 PPFIBP1 Hs00186240_m1 NM_004792 PPIG Hs01081188_gH AF070670 PPM1A Hs00236053_m1 NM_002714 PPP1R10 Hs00160391_m1 NM_002480 PPP1R12A Hs01552893_m1 NM_002481 PPP1R12B Hs00364082_m1 NM_002715 PPP2CA Hs00427260_m1 NM_001007257 PRDM2 Hs00210612_m1 NM_005809 PRDX2 Hs00853603_s1 BC002763 PRKAR2A Hs00177760_m1 NM_003690 PRKRA Hs00269379_m1 NM_003690 PRKRA Hs00269379_m1 NM_018061 PRPF38B Hs00216242_m1 NM_018304 PRR11 Hs00383634_m1 NM_018304 PRR11 Hs00383634_m1 NM_015172 PRRC2C Hs00324618_m1 NM_015172 PRRC2C Hs00324618_m1 NM_015172 PRRC2C Hs00324618_m1 NM_015172 PRRC2C Hs00324618_m1 NM_000021 PSEN1 Hs00997789_m1 NM_002840 PTPRF Hs00892984_m1 AF112206 RAB14 Hs00249440_m1 NM_021252 RAB18 Hs00222021_m1 NM_012197 RABGAP1 Hs00170910_m1 NM_014990 RALGAPA1 Hs01054485_m1 NM_014990 RALGAPA1 Hs01054485_m1 NM_002890 RASA1 Hs00243115_m1 NM_006506 RASA2 Hs00183550_m1 NM_006910 RBBP6 Hs00199439_m1 NM_006910 RBBP6 Hs00199439_m1 NM_001031695 RBFOX2 Hs00329214_s1 NM_021239 RBM25 Hs00402198_m1 NM_021239 RBM25 Hs00402198_m1 NM_004902 RBM39 Hs00705337_s1 AF107493 RBM5 Hs00172952_m1 NM_005777 RBM6 Hs00172915_m1 NM_002897 RBMS1 Hs00249930_s1 NM_001008710 RBPMS Hs00199302_m1 NM_005669 REEP5 Hs00382478_m1 NM_012102 RERE Hs00201558_m1 NM_012102 RERE Hs00201558_m1 NM_016316 REV1 Hs00249411_m1 NM_018151 RIF1 Hs00871714_m1 NM_003831 RIOK3 Hs01590882_m1 NM_003730 RNASET2 Hs00427770_m1 328 NM_017610 RNF111 Hs00214108_m1 NM_017619 RNPC3 Hs00384230_m1 NM_017619 RNPC3 Hs00384230_m1 NM_002943 RORA Hs00536545_m1 NM_002943 RORA Hs00536545_m1 NM_001030 RPS27 Hs01378332_g1 NM_001003698 RREB1 Hs00171486_m1 NM_001003698 RREB1 Hs00171486_m1 NM_018364 RSBN1 Hs00218019_m1 NM_007008 RTN4 Hs01103690_m1 AF112221 RUFY3 Hs01127885_m1 NM_012234 RYBP Hs00393028_m1 NM_012234 RYBP Hs00393028_m1 NM_015474 SAMHD1 Hs00210016_m1 NM_004719 SCAF11 Hs00190882_m1 NM_004719 SCAF11 Hs00190882_m1 NM_016106 SCFD1 Hs00794863_m1 NM_006643 SDCCAG3 Hs00374642_m1 NM_006642 SDCCAG8 Hs00394864_m1 NM_003003 SEC14L1 Hs00608163_m1 NM_014701 SECISBP2L Hs00299746_m1 NM_015571 SENP6 Hs00210213_m1 NM_015571 SENP6 Hs00210213_m1 NM_000185 SERPIND1 Hs00164821_m1 NM_001005526 SF3B1 Hs00202782_m1 NM_001005526 SF3B1 Hs00202782_m1 NM_004592 SFSWAP Hs00190197_m1 NM_004592 SFSWAP Hs00190197_m1 NM_022754 SFXN1 Hs00224259_m1 NM_014853 SGSM2 Hs00390054_m1 NM_020870 SH3RF1 Hs00325806_m1 NM_173082 SHPRH Hs00542737_m1 NM_000617 SLC11A2 Hs00167206_m1 NM_021977 SLC22A3 Hs02382478_s1 NM_018155 SLC25A36 Hs00216785_m1 NM_018155 SLC25A36 Hs00216785_m1 NM_018155 SLC25A36 Hs00216785_m1 NM_024881 SLC35E1 Hs00603867_m1 NM_182838 SLC35E2 Hs01568716_m1 AF010601 SMAD5 Hs00195437_m1 NM_003074 SMARCC1 Hs02559508_s1 NM_003074 SMARCC1 Hs02559508_s1 U32581 SMG1 Hs00247891_m1 NM_018225 SMU1 Hs00739861_mH NM_020429 SMURF1 Hs00410929_m1 329 NM_030918 SNX27 Hs00229472_m1 NM_030918 SNX27 Hs00229472_m1 NM_003603 SORBS2 Hs00243432_m1 NM_015001 SPEN Hs00209232_m1 NM_016630 SPG21 Hs00213341_m1 NM_006717 SPIN1 Hs00198748_m1 NM_139168 SREK1 Hs00295416_s1 NM_182691 SRPK2 Hs00795102_m1 NM_005839 SRRM1 Hs00366642_m1 NM_016333 SRRM2 Hs00249492_m1 NM_004768 SRSF11 Hs00191108_m1 NM_018984 SSH1 Hs00368014_m1 NM_005086 SSPN Hs00296706_s1 NM_016028 SUV420H1 Hs00211300_m1 NM_003487 TAF15 Hs00185844_m1 NM_152334 TARSL2 Hs00406324_m1 NM_014744 TBC1D5 Hs00207213_m1 NM_005647 TBL1X Hs00183329_m1 NM_006706 TCERG1 Hs00198676_m1 NM_014972 TCF25 Hs00248217_m1 NM_005653 TFCP2 Hs00232185_m1 NM_024831 TGS1 Hs00227358_m1 NM_005119 THRAP3 Hs00371602_m1 NM_005119 THRAP3 Hs00371602_m1 NM_017736 THUMPD1 Hs00430083_g1 NM_003257 TJP1 Hs00543824_m1 NM_032027 TM2D1 Hs00608855_m1 NM_024780 TMC5 Hs00227103_m1 NM_006827 TMED10 Hs01655242_g1 NM_018374 TMEM106B Hs00332866_s1 NM_030923 TMEM163 Hs00379686_m1 NM_182526 TMEM229B Hs00328230_s1 NM_032824 TMEM87B Hs00262432_m1 NM_003747 TNKS Hs00186671_m1 NM_002270 TNPO1 Hs00541872_g1 NM_002270 TNPO1 Hs00541872_g1 NM_014494 TNRC6A Hs00379422_m1 NM_014494 TNRC6A Hs00379422_m1 NM_001024843 TNRC6B Hs00324606_m1 NM_001024843 TNRC6B Hs00324606_m1 NM_003286 TOP1 Hs00243257_m1 NM_014828 TOX4 Hs00706258_s1 NM_003290 TPM4 Hs01861627_g1 NM_003292 TPR Hs00162918_m1 NM_013293 TRA2A Hs00203263_m1 330 NM_013293 TRA2A Hs00203263_m1 NM_013293 TRA2A Hs00203263_m1 NM_015906 TRIM33 Hs00210808_m1 NM_007118 TRIO Hs00179276_m1 NM_007118 TRIO Hs00179276_m1 AF091395 TRIO Hs00179276_m1 NM_018128 TSR1 Hs00911303_g1 NM_133462 TTC14 Hs00326671_m1 NM_001001894 TTC3 Hs00268613_m1 NM_144596 TTC8 Hs00292684_m1 NM_015072 TTLL5 Hs00367300_m1 NM_006659 TUBGCP2 Hs00943104_m1 NM_001007466 TULP4 Hs00220363_m1 NM_001008224 UACA Hs00326052_m1 NM_003337 UBE2B Hs00163311_m1 NM_003339 UBE2D2 Hs00366152_m1 NM_003339 UBE2D2 Hs00366152_m1 NM_014671 UBE3C Hs00904531_m1 NM_007106 UBL3 Hs01018736_g1 NM_016936 UBN1 Hs00213514_m1 NM_020131 UBQLN4 Hs00702633_s1 NM_014607 UBXN4 Hs00908410_m1 NM_175866 UHMK1 Hs01111764_m1 NM_003366 UQCRC2 Hs00996395_m1 NM_003940 USP13 Hs00187594_m1 NM_015017 USP33 Hs00367269_m1 NM_014709 USP34 Hs00611330_m1 NM_014709 USP34 Hs00611330_m1 NM_003363 USP4 Hs01100028_g1 NM_018218 USP40 Hs00332716_m1 NM_018218 USP40 Hs00332716_m1 NM_014667 VGLL4 Hs00382574_m1 NM_015243 VPS13B Hs00382324_m1 NM_024667 VPS37B Hs01091832_m1 NM_006990 WASF2 Hs00819075_gH NM_003941 WASL Hs00187614_m1 NM_015910 WDPCP Hs00210831_m1 NM_005112 WDR1 Hs00213813_m1 NM_025234 WDR61 Hs00228800_m1 NM_024102 WDR77 Hs00560455_m1 NM_018979 WNK1 Hs00219183_m1 NM_018979 WNK1 Hs00219183_m1 NM_018979 WNK1 Hs00219183_m1 NM_015626 WSB1 Hs01075504_g1 NM_015238 WWC1 Hs00392086_m1 331 NR_001564 XIST Hs00300535_s1 NM_014263 YME1L1 Hs00907919_m1 NM_001005404 YPEL2 Hs01357188_m1 NM_003403 YY1 Hs00231533_m1 NM_014007 ZBTB43 Hs00706047_s1 NM_014007 ZBTB43 Hs00706047_s1 NM_030751 ZEB1 Hs01566407_m1 NM_019006 ZFAND6 Hs00375275_m1 NM_053023 ZFP91 Hs00364919_m1 NM_016107 ZFR Hs00211515_m1 NM_003453 ZMYM2 Hs00268802_m1 NM_006624 ZMYND11 Hs00198349_m1 NM_021964 ZNF148 Hs00222661_m1 NM_021964 ZNF148 Hs00222661_m1 NM_021964 ZNF148 Hs00222661_m1 NM_033288 ZNF160 Hs00369142_m1 NM_001007088 ZNF182 Hs01588257_m1 NM_005649 ZNF354A Hs01921591_s1 NM_021188 ZNF410 Hs00221828_m1 NM_021646 ZNF500 Hs00832064_s1 NM_017656 ZNF562 Hs00864102_g1 NM_030972 ZNF611 Hs01864525_s1 NM_198484 ZNF621 Hs01395092_m1 NM_001014972 ZNF638 Hs00205587_m1 NM_152320 ZNF641 Hs01075391_m1 AK021514 ZNF721 Hs01382452_m1 NM_152458 ZNF785 Hs00738331_m1 STIP1 Número de acceso Símbolo del (GenBank) gen TaqMan®Assay (extremo 3') NM_005692 ABCF2 Hs00255026_m1 U18197 ACLY Hs00982738_m1 NM_007274 ACOT7 Hs00739006_m1 NM_004300 ACP1 Hs00244706_g1 NM_005736 ACTR1A Hs00194913_m1 NM_001005386 ACTR2 Hs00855199_g1 NM_004208 AIFM1 Hs00377585_m1 NM_024595 AKIRIN1 Hs00607590_m1 NM_018064 AKIRIN2 Hs00363236_m1 NM_016237 ANAPC5 Hs01102438_m1 NM_017747 ANKHD1 Hs00368160_m1 NM_006305 ANP32A Hs00829953_g1 NM_001283 AP1S1 Hs00609701_m1 NM_001283 AP1S1 Hs00609701_m1 332 AF229254 API5 Hs00972630_g1 NM_006595 API5 Hs00972630_g1 NM_001024226 ARF1 Hs00761273_s1 NM_001024226 ARF1 Hs00761273_s1 M57763 ARF6 Hs00761810_s1 NM_006421 ARFGEF1 Hs00963238_m1 NM_003224 ARFRP1 Hs00182389_m1 NM_004309 ARHGDIA Hs00976924_g1 D13989 ARHGDIA Hs00976924_g1 AF019888 ARPC4 Hs00194811_m1 BC000018 ARPC5L Hs00229649_m1 NM_014109 ATAD2 Hs00905075_m1 NM_001686 ATP5B Hs00969569_m1 NM_001690 ATP6V1A Hs00156003_m1 NM_001695 ATP6V1C1 Hs00940702_m1 NM_015878 AZIN1 Hs00210634_m1 NM_004324 BAX Hs99999001_m1 NM_001191 BCL2L1 Hs00169141_m1 NM_001191 BCL2L1 Hs00169141_m1 NM_014739 BCLAF1 Hs00602256_m1 AB028869 BIRC5 Hs00153353_m1 NM_001018055 BRCC3 Hs02386484_g1 NM_001728 BSG Hs00936295_m1 NM_004336 BUB1 Hs01557701_m1 NM_007176 C14orf1 Hs00969092_m1 NM_015609 C1orf144 Hs00379295_m1 NM_022758 C6orf106 Hs00256056_s1 NM_030939 C6orf62 Hs00229553_m1 NM_023080 C8orf33 Hs00535769_m1 NM_001219 CALU Hs00154230_m1 U67280 CALU Hs00154230_m1 NM_001024649 CANX Hs01558409_m1 L18887 CANX Hs01558409_m1 NM_005898 CAPRIN1 Hs01075318_m1 NM_001014437 CARS Hs01000965_m1 NM_001237 CCNA2 Hs00996789_g1 NM_031966 CCNB1 Hs01030103_m1 AF112857 CCNE2 Hs01051894_m1 U17105 CCNF Hs00171049_m1 NM_006431 CCT2 Hs00197562_m1 NM_006429 CCT7 Hs00362446_m1 NM_001253 CDC5L Hs00154370_m1 NM_080668 CDCA5 Hs00293564_m1 L08599 CDH1 Hs01013958_m1 D88357 CDK1 Hs00364293_m1 333 NM_001786 CDK1 Hs00364293_m1 AB012305 CDK2 Hs01548894_m1 NM_017548 CDV3 Hs00250190_m1 NM_203463 CERS6 Hs00826756_m1 NM_020412 CHMP1B Hs00252683_s1 NM_013943 CLIC4 Hs00749895_s1 BC004467 CLINT1 Hs00206388_m1 NM_004371 COPA Hs00189232_m1 NM_004379 CREB1 Hs00231713_m1 NM_004379 CREB1 Hs00231713_m1 NM_001895 CSNK2A1 Hs00751002_s1 NM_001895 CSNK2A1 Hs00751002_s1 BC000021 CYB561 Hs00157220_m1 NM_030579 CYB5B Hs02378162_s1 NM_001916 CYC1 Hs00357717_m1 NM_000786 CYP51A1 Hs01567880_g1 NM_139179 DAGLB Hs00373700_m1 NM_001348 DAPK3 Hs00154676_m1 NM_014764 DAZAP2 Hs00429643_m1 J03208 DBT Hs00157226_m1 NM_025230 DCAF11 Hs00228767_m1 NM_032486 DCTN5 Hs00739985_m1 NM_020640 DCUN1D1 Hs00603078_m1 NM_024050 DDA1 Hs00610984_m1 D29643 DDOST Hs00193263_m1 NM_018332 DDX19A Hs01035515_m1 NM_001356 DDX3X Hs00606179_m1 AF061337 DDX3X Hs00606179_m1 AF064605 DEDD Hs00172768_m1 NM_003677 DENR Hs00795562_s1 NM_024295 DERL1 Hs00251475_s1 NM_001357 DHX9 Hs00357476_m1 NM_001357 DHX9 Hs00357476_m1 NM_001363 DKC1 Hs00154737_m1 U59151 DKC1 Hs00154737_m1 NM_001539 DNAJA1 Hs00266011_m1 NM_006145 DNAJB1 Hs00428680_m1 NM_001375 DNASE2 Hs00923081_m1 NM_052951 DNTTIP1 Hs00369479_m1 NM_006052 DSCR3 Hs00195931_m1 NM_006579 EBP Hs00198130_m1 NM_018098 ECT2 Hs00216455_m1 NM_025083 EDC3 Hs00257810_m1 NM_004953 EIF4G1 Hs00191933_m1 AF022229 EIF6 Hs00158272_m1 334 NM_001419 ELAVL1 Hs00171309_m1 NM_001428 ENO1 Hs00361415_m1 NM_004436 ENSA Hs00705265_s1 NM_004446 EPRS Hs00270083_m1 NM_006459 ERLIN1 Hs00197691_m1 NM_017697 ESRP1 Hs00214472_m1 NM_006544 EXOC5 Hs00272473_m1 NM_014285 EXOSC2 Hs00204705_m1 NM_019037 EXOSC4 Hs00363401_g1 NM_019037 EXOSC4 Hs00363401_g1 NM_019037 EXOSC4 Hs00363401_g1 NM_003379 EZR Hs00931646_m1 NM_003379 EZR Hs00931646_m1 NM_003379 EZR Hs00931646_m1 NM_030919 FAM83D Hs00383338_m1 NM_004461 FARSA Hs00189494_m1 NM_012170 FBXO22 Hs00201796_m1 NM_012177 FBXO5 Hs00559989_m1 NM_004111 FEN1 Hs00748727_s1 NM_000143 FH Hs00895618_m1 BC005147 FKBP1A Hs00356621_g1 NM_002014 FKBP4 Hs00427038_g1 NM_025207 FLAD1 Hs00611011_m1 NM_144600 FOPNL Hs00376034_m1 NM_004514 FOXK2 Hs00536139_s1 NM_007085 FSTL1 Hs00907496_m1 NM_013393 FTSJ2 Hs00203647_m1 NM_001011537 FYTTD1 Hs00260265_m1 NM_012297 G3BP2 Hs00907696_m1 NM_012297 G3BP2 Hs00907696_m1 NM_002041 GABPB1 Hs00242573_m1 NM_002046 GAPDH Hs03929097_g1 NM_002046 GAPDH Hs03929097_g1 NM_002046 GAPDH Hs03929097_g1 NM_000819 GART Hs00531926_m1 NM_000819 GART Hs00531926_m1 D13988 GDI2 Hs00357525_m1 NM_024996 GFM1 Hs00227997_m1 NM_032380 GFM2 Hs00260735_m1 NM_002056 GFPT1 Hs00899865_m1 NM_015044 GGA2 Hs00209277_m1 AF131820 GHITM Hs00205205_m1 NM_001499 GLE1 Hs00155273_m1 AF118652 GLRX3 Hs01582641_g1 NM_024656 GLT25D1 Hs00430697_g1 335 NM_000405 GM2A Hs00166197_m1 NM_000405 GM2A Hs00166197_m1 NM_006572 GNA13 Hs01116113_g1 NM_002074 GNB1 Hs00181845_m1 NM_002076 GNS Hs00157741_m1 AF229796 GOSR2 Hs00269922_m1 NM_024531 GPR172A Hs01859203_s1 NM_025196 GRPEL1 Hs00379355_m1 BC004472 GTF2I Hs00263393_m1 NM_005333 HCCS Hs00193443_m1 NM_030789 HM13 Hs00383699_m1 NM_016185 HN1 Hs00602957_m1 NM_144570 HN1L Hs00375909_m1 NM_004499 HNRNPAB Hs00954054_g1 NM_004500 HNRNPC Hs01028910_g1 NM_004966 HNRNPF Hs00359014_m1 NM_032383 HPS3 Hs00289968_m1 NM_005526 HSF1 Hs00232134_m1 AF275719 HSP90AB1 Hs00607336_gH NM_007355 HSP90AB1 Hs00607336_gH NM_003299 HSP90B1 Hs00427665_g1 BC002526 HSPA4 Hs00382884_m1 AF352832 HSPA8 Hs00852842_gH NM_004134 HSPA9 Hs00269818_m1 NM_002156 HSPD1 Hs01866140_g1 NM_006644 HSPH1 Hs00971475_m1 NM_006410 HTATIP2 Hs00185131_m1 NM_005530 IDH3A Hs00194253_m1 NM_004515 ILF2 Hs01080165_g1 AF151831 KBTBD2 Hs00736546_m1 NM_015483 KBTBD2 Hs00736546_m1 AF151086 KBTBD4 Hs00560341_m1 NM_018992 KCTD5 Hs00368026_m1 NM_007317 KIF22 Hs00173253_m1 AY026505 KIF2C Hs00901710_m1 BC002374 KPNA1 Hs00158502_m1 BC005978 KPNA2 Hs00818252_g1 U93240 KPNA4 Hs00601211_m1 NM_018407 LAPTM4B Hs00363282_m1 NM_052879 LARP4 Hs00369419_m1 AF348513 LMBR1 Hs00223794_m1 NM_012321 LSM4 Hs00202406_m1 NM_002355 M6PR Hs01124302_m1 NM_002745 MAPK1 Hs01052196_m1 AF100544 MAPK14 Hs00176248_m1 336 NM_001006617 MAPKAP1 Hs00225549_m1 NM_012325 MAPRE1 Hs01121102_g1 NM_004990 MARS Hs00192202_m1 NM_005911 MAT2A Hs00428515_g1 NM_002382 MAX Hs00231142_m1 M64240 MAX Hs00231142_m1 NM_002383 MAZ Hs00159087_m1 NM_021960 MCL1 Hs01050896_m1 NM_003906 MCM3AP Hs00172706_m1 NM_005914 MCM4 Hs00381539_m1 NM_005914 MCM4 Hs00381539_m1 NM_004275 MED20 Hs00385586_m1 NM_002417 MKI67 Hs01032435_g1 NM_014160 MKRN2 Hs00274055_m1 NM_170607 MLX Hs00538258_m1 NM_032478 MRPL38 Hs00375656_m1 NM_014050 MRPL42 Hs00204112_m1 NM_022915 MRPL44 Hs00224773_m1 NM_018141 MRPS10 Hs00216720_m1 NM_021107 MRPS12 Hs00221633_m1 AB049952 MRPS18A Hs00606652_m1 BC005373 MRPS18B Hs00204096_m1 NM_015971 MRPS7 Hs00211079_m1 NM_016183 MRTO4 Hs00607404_g1 D89646 MSH6 Hs00264721_m1 AF344882 MST4 Hs00213049_m1 NM_014342 MTCH2 Hs00819318_g1 NM_014637 MTFR1 Hs00206110_m1 NM_003828 MTMR1 Hs00382245_m1 NM_025146 NAA50 Hs00363889_m1 NM_023018 NADK Hs00224899_m1 NM_023018 NADK Hs00224899_m1 NM_007362 NCBP2 Hs00201247_m1 NM_002505 NFYA Hs00953589_m1 NM_003634 NIPSNAP1 Hs00186287_m1 NM_000269 NME1 Hs02621161_s1 NM_004741 NOLC1 Hs00170493_m1 NM_004741 NOLC1 Hs00170493_m1 L14599 NONO Hs00939763_g1 BC003129 NONO Hs00939763_g1 NM_006392 NOP56 Hs00197340_m1 NM_005234 NR2F6 Hs00172870_m1 NM_016143 NSFL1C Hs00820401_m1 NM_018230 NUP133 Hs00217272_m1 NM_007172 NUP50 Hs00855432_g1 337 NM_012346 NUP62 Hs02621445_s1 NM_138459 NUS1 Hs00604633_s1 AF201942 NXT2 Hs00218849_m1 NM_017670 OTUB1 Hs00214346_m1 NM_017670 OTUB1 Hs00214346_m1 NM_006452 PAICS Hs00272390_m1 NM_152716 PATL1 Hs00405584_m1 NM_152716 PATL1 Hs00405584_m1 D25547 PCMT1 Hs00193600_m1 NM_014891 PDAP1 Hs01634881_s1 NM_001002810 PDE4DIP Hs00223575_m1 U67932 PDE7A Hs00331173_s1 NM_005742 PDIA6 Hs01012536_m1 BC001312 PDIA6 Hs01012536_m1 NM_005742 PDIA6 Hs01012536_m1 NM_002631 PGD Hs00427230_m1 NM_000291 PGK1 Hs00943178_g1 NM_000291 PGK1 Hs00943178_g1 NM_000291 PGK1 Hs00943178_g1 NM_006667 PGRMC1 Hs00998344_m1 NM_002634 PHB Hs00855044_g1 NM_001008660 PICALM Hs00999731_g1 NM_001008660 PICALM Hs00999731_g1 NM_007183 PKP3 Hs00170887_m1 NM_005030 PLK1 Hs00983233_g1 NM_020143 PNO1 Hs00220044_m1 NM_032311 POLDIP3 Hs00276880_s1 NM_004805 POLR2D Hs00797358_s1 NM_002695 POLR2E Hs00267554_m1 NM_017739 POMGNT1 Hs00214729_m1 AB000635 PPP2R5D Hs00605059_m1 NM_006247 PPP5C Hs00196577_m1 NM_001032381 PQBP1 Hs00172888_m1 L19184 PRDX1 Hs00602020_mH AF197952 PRDX5 Hs00738905_g1 NM_000947 PRIM2 Hs00168726_m1 M18468 PRKAR1A Hs00267597_m1 U34994 PRKDC Hs00179161_m1 NM_001536 PRMT1 Hs01587651_g1 NM_015629 PRPF31 Hs00210306_m1 NM_012469 PRPF6 Hs00202956_m1 NM_002764 PRPS1 Hs00751338_s1 M64992 PSMA1 Hs01027360_g1 NM_002792 PSMA7 Hs00895424_m1 NM_002804 PSMC3 Hs00267682_m1 338 NM_002807 PSMD1 Hs00160631_m1 AF001212 PSMD11 Hs00160660_m1 NM_002816 PSMD12 Hs00738496_g1 NM_002812 PSMD8 Hs00601309_m1 BC002684 PSME3 Hs00195072_m1 NM_005789 PSME3 Hs00195072_m1 NM_002819 PTBP1 Hs00243060_m1 NM_005607 PTK2 Hs01056457_m1 NM_016395 PTPLAD1 Hs00179633_m1 AF217197 PUF60 Hs01050528_g1 NM_004161 RAB1A Hs00800204_s1 NM_006861 RAB35 Hs00199284_m1 NM_006861 RAB35 Hs00199284_m1 NM_004162 RAB5A Hs00702360_s1 AF074717 RAD1 Hs00421891_g1 NM_006265 RAD21 Hs00366726_m1 AF054183 RAN Hs00741099_g1 NM_002882 RANBP1 Hs01597912_g1 NM_005493 RANBP9 Hs01116140_m1 NM_002883 RANGAP1 Hs00610049_m1 NM_002886 RAP2B Hs00267932_s1 NM_005610 RBBP4 Hs01568507_g1 NM_001269 RCC1 Hs00154399_m1 M87338 RFC2 Hs00945948_m1 NM_002914 RFC2 Hs00945948_m1 NM_002915 RFC3 Hs00161357_m1 NM_007370 RFC5 Hs00738859_m1 NM_003831 RIOK3 Hs01590882_m1 NM_018683 RNF114 Hs00218782_m1 BC003560 RPN2 Hs00955802_m1 NM_001033 RRM1 Hs01040698_m1 BC001886 RRM2 Hs01072069_g1 NM_003707 RUVBL1 Hs00186558_m1 NM_017988 SCYL2 Hs00250551_m1 NM_003001 SDHC Hs01698067_s1 NM_006363 SEC23B Hs00197211_m1 AF346602 SEC61A1 Hs01037684_m1 NM_005412 SHMT2 Hs00193658_m1 NM_004207 SLC16A3 Hs00358829_m1 U15939 SLC19A1 Hs00953345_m1 NM_005660 SLC35A2 Hs00194644_m1 NM_016045 SLMO2 Hs00429845_m1 NM_003072 SMARCA4 Hs00231324_m1 BC006215 SMEK2 Hs00383284_m1 NM_003091 SNRPB Hs00268321_m1 339 NM_003971 SPAG9 Hs00187715_m1 NM_003129 SQLE Hs01123768_m1 NM_003137 SRPK1 Hs00177298_m1 NM_003139 SRPR Hs00162326_m1 NM_021203 SRPRB Hs00253639_m1 NM_015908 SRRT Hs01056389_g1 NM_006924 SRSF1 Hs00199471_m1 AF047448 SRSF10 Hs00793055_g1 NM_003016 SRSF2 Hs01923929_s1 NM_003017 SRSF3 Hs00751507_s1 AF343880 SS18 Hs01075912_m1 NM_001007559 SS18 Hs01075912_m1 NM_003144 SSR1 Hs00162340_m1 NM_003144 SSR1 Hs00162340_m1 NM_003146 SSRP1 Hs00172629_m1 NM_006819 STIP1 Hs00428979_m1 NM_004177 STX3 Hs00927422_m1 NM_006936 SUMO3 Hs00739248_m1 NM_007192 SUPT16H Hs00200446_m1 NM_033161 SURF4 Hs00369130_m1 AF078866 SURF4 Hs00369130_m1 BC002616 TAGLN2 Hs00761239_s1 NM_144582 TEX261 Hs00375962_m1 NM_003234 TFRC Hs02559818_s1 NM_005782 THOC4 Hs00362329_m1 NM_005782 THOC4 Hs00362329_m1 BC004439 TIMM17A Hs00197081_m1 NM_006327 TIMM23 Hs00197056_m1 NM_001001563 TIMM50 Hs00859225_m1 NM_001064 TKT Hs01115545_m1 NM_014742 TM9SF4 Hs00207196_m1 NM_006815 TMED2 Hs00607277_m1 NM_006815 TMED2 Hs00607277_m1 NM_017870 TMEM132A Hs00250439_m1 NM_015257 TMEM194A Hs00322591_m1 NM_152464 TMEM199 Hs00382320_m1 NM_030755 TMX1 Hs00702835_s1 NM_020243 TOMM22 Hs00560379_g1 NM_014828 TOX4 Hs00706258_s1 NM_001025252 TPD52 Hs00896046_m1 AF098158 TPX2 Hs00201616_m1 NM_014294 TRAM1 Hs01116824_m1 AF230394 TRIM27 Hs00179059_m1 NM_016404 TRMT112 Hs00829096_g1 NM_003496 TRRAP Hs01591130_m1 340 NM_004622 TSN Hs00172824_m1 NM_018128 TSR1 Hs00911303_g1 NM_024331 TTPAL Hs00225689_m1 NM_006082 TUBA1B Hs00744842_sH BC004949 TUBA1C Hs00733770_m1 BC005946 TUBA1C Hs00733770_m1 BC005838 TUBB Hs00763510_gH AF141349 TUBB Hs00763510_gH NM_007279 U2AF2 Hs00200737_m1 NM_003336 UBE2A Hs00163308_m1 NM_007019 UBE2C Hs00853610_g1 NM_003340 UBE2D3 Hs00701790_s1 NM_003343 UBE2G2 Hs00163326_m1 NM_003344 UBE2H Hs00163327_m1 NM_003969 UBE2M Hs01920984_g1 NM_003348 UBE2N Hs00854751_s1 NM_014501 UBE2S Hs00819350_m1 AB032931 UBE2T Hs00204359_m1 NM_001032288 UBE2V1 Hs00851874_g1 NM_006048 UBE4B Hs00195897_m1 NM_014607 UBXN4 Hs00908410_m1 AF237290 UCK1 Hs00258815_m1 NM_030930 UNC93B1 Hs00276771_m1 BC000263 USP10 Hs01019015_m1 NM_005153 USP10 Hs01019015_m1 NM_032334 UTP23 Hs00260536_m1 NM_004781 VAMP3 Hs00922166_m1 AF100752 VCP Hs00997642_m1 NM_003374 VDAC1 Hs01631624_gH NM_018206 VPS35 Hs00372497_m1 NM_016485 VTA1 Hs00212881_m1 M61715 WARS Hs00188259_m1 BC006351 WDR74 Hs00276510_m1 NM_020750 XPO5 Hs00382453_m1 BC000129 XPO5 Hs00382453_m1 NM_012255 XRN2 Hs00560009_m1 NM_004559 YBX1 Hs00829347_g1 NM_030799 YIPF5 Hs01093311_m1 NM_006555 YKT6 Hs00559914_m1 NM_024640 YRDC Hs00226428_m1 NM_003406 YWHAZ Hs00852925_sH BC003623 YWHAZ Hs00852925_sH U28964 YWHAZ Hs01122447_g1 NM_015457 ZDHHC5 Hs00379814_m1 NM_006782 ZFPL1 Hs00198955_m1 341 NM_014205 ZNHIT2 Hs00274099_s1 342

P201430887 ES 2 553 786 A1 09-06-2014 LISTADO DE SECUENCIAS   <110> Fundación Hospital la Paz <120> MÉTODO PARA LA SUBCLASIFICACIÓN DE TUMORES <130> ES1660.22 <160> 36 <170> PatentIn version 3.5 <210> 1 <211> 10925 <212> DNA <213> Homo sapiens <400> 1 cggccgtgat ttgctccggt ttcaaaaggg aggaagggcg ggaatgctcg ggaagagcct 60 ggggttggca ggacctttag ggggtggaat gaatgtcgtg agggcgagta aggaggtacc 120 ggctggggct gaaaatgcgc acggggacca tgagcgtgat tcgccctgag ccgctgcgaa 180 cgccctgcga gctggggtgg ccctggaggt cctggagcag aagctaggtt cccgcagagt 240 ccgctgcagc gccgctggcg atcgggctgg gtcccatttt ccacgaaaag tcccgcggct 300 tcggccgcgg aggtgctgga gcctttgcgc tcagacgaag ggccgaacgg ccagggccag 360 gccgcgtctt cagagcctgg cgagggtctc gcgctgctgg gaaggcggag acgccggggc 420 gcgcgtgcac cctcgcgcct gcagcgccgc gcacggccgc caggtgccgc tgtggcgctc 480 agcgcgccgc ccgccccgcc ccagggaacg cgaaagtggc gcgggcctgg acggcgggac 540 ggaccacgta gggcgctgag aaggtcgcgc cacggtgggc ggggctccgg gcccctcccc 600 ctcggccgcc ctcgcgctgt ggttcgctcc gggcgcgctg cgctcgtgag ttcccaggag 660 gcctggcggg caccgtaacc agcgccgcgg acaccggcac cggcgccacg gactccgcag 720 gaccccgcgc ccgccgccgc cgctatgctg gggctgctgg tggcgttgct ggccctgggg 780 ctcgctgtct ttgcgctgct ggacgtctgg tacctggtgc gccttccgtg cgccgtgctg 840 cgcgcgcgcc tgctgcagcc gcgcgtccgt gacctgctag ctgagcagcg cttcccgggc 900 cgcgtgctgc cctcggactt ggacctgctg ctgcacatga acaacgcgcg ctacctgcgc 960 gaggccgact ttgcgcgcgt cgcgcacctg acccgctgcg gggtgctcgg ggcgctgagg 1020 gagttgcggg cgcacacggt gctggcggcc tcgtgcgcgc gccaccgccg ctcgctgcgc 1080 ctgctggagc ccttcgaggt gcgcacccgc ctgctgggct gggacgaccg cgcgttctac 1140 ctggaggcgc gctttgtcag cctgcgggac ggcttcgtgt gcgcgctgct gcgcttccgg 1200 cagcacctgc tgggcacctc acccgagcgc gtcgtgcagc acctgtgcca gcgcagggtg 1260 agcggccccc gcccctggcc ccggagcacg gcctttgtgg gacctccggg ggctcctcct 1320 agtccctggc cccctcccct agggaaggcc cgctgcctgc acctctttcg gatactgctg 1380 gagtcctgcc tcttaccgct cccgcccctc cctctctacc gggggcattc ctcactgatg 1440 cctttgttcg tgggggttcc tagggtcccc gaatcaactc ttcatagtcg ggcttagcgt 1500 gcttccctcc tgccatttct taacctggcc cctcacggtt tcgtgttcac ccctctcctc 1560 Página 1

P201430887 ES 2 553 786 A1 09-06-2014 tctcctggta ctctgttctg tggctggagt gttgacctct ctggtccttg gtcctgaata 1620   taggttggag aggtgatcag ttagaagagg ttcctaggag ttcccgagga cctgagcccc 1680 cctttcacac agcttagagc tgaagggctg ggttctggtc acctgggttt ggggttgagg 1740 tattgagccg agtagctgaa agccttctgg cctttctgca gttggagaga ggagggccat 1800 gcacctccca gggctcgctc ctcccagcag ggcagaaccg cccctgcagc atggcacctg 1860 gggccctggg gacggccacc aggccgatgt ggccagacca gttgccagaa aagttgcctg 1920 gagcgtccgt gcaggaagcc agggcctgtg cacccctggt gtgcccttag ggcactgccc 1980 tctccggtct cggacaggtg cctcccgagc agacgagggt caacgtctca tctcagtcct 2040 gatgttacag gaaagggatt cagatccaga cctcaaggga gggttcttgg atcttgtgta 2100 agaaagaact cagggcgagt ctgcagcgca cagtgaaagc aagtttatta aggtaaagcg 2160 gtgaaagaat agctggtccg tagacccagt agcatgttcc tgtaagagga ggaacgcgtc 2220 caccctaggt gcaatgcttg tatatatggg gagatgtgat ctgctacaag ggtttgtgat 2280 aaaggagtaa ttttcttaat tactatattt tgcaagaatc aatattacta ttttcttttt 2340 tttttttttt tttttcagac ggattctcac tctgtcgccc aggctggagt gcagtggcgt 2400 gatctcggct cactgcaacc tccgccttcc gggttcacgc cattctcctg cttcagcctc 2460 cccactagct gggactacgg cgccagccac cacgcccggc taattttttg tatttttagt 2520 agagacgggg tttcaaaatc aggaatgcct ttgttctcca gacatcggga tatctggaca 2580 ctcccaagtc tgggtctctt tagtaaacat tattaatttg ttcccttaac tgtgtttgaa 2640 acgcttgttc cccggtgccg taaagaaata gcacgtgaac ataaatttaa tttcctcagc 2700 aaggccattt ttacttcctg cagaaagggt acactcgcca gcagctttgc catgagagta 2760 caccgaacaa aggagacagg ctcatttata acctgatgtg taacaatcgc ttttatttaa 2820 agtgcgaacg gaatatttaa tccatttcag ccagggattt gcatcttgat actctctcga 2880 tggctaaggt ctgttttaga tctcttattt ttacaataga caccctagtt ttattattag 2940 atgtagaagc aaccggtgtg agatctagaa ctgaggctac tgaagaaggg ggagatgggg 3000 gaataatgcg tatttaaaaa atacctaggg ggtcttttcc atttatgtca atccccatac 3060 cacagaagcg actgagggca ggtctagagt tagttaaggt ggaggtggtg atagagaagg 3120 acagggttac actgataagg ctgacagttc gaaagggtag tcctttcagt gaaatagatg 3180 aggggtttta gatctgcaca gacctttttc ttggaagttt aactttgctc ctgagcagtt 3240 gaatgtgtat agtcccgttt actacaaagt tggcaggcta taggagcaga acattggcat 3300 cttggctgca ggtcattacg ataatgagag ctaggggtaa ccatgtccat cagagggctg 3360 ggacgtaagc atttgtgtga aaaggctagc tgttgttgat cttttacatt tccgcaaggt 3420 atgacagaac aagcattcaa ggcggtggtc tgaggtgagt tagttacagt aataacaaag 3480 gcgctagtaa caataaggaa aggaagcaat atgaaggtac aggaaaatta agctttcttt 3540 aactttaact tagtaggatt ggtcctagta cagtcatcca tgattctgag agaaagatgt 3600 tttcttgact ggagtgtggt cgtttttttc ttggctctgc ggatggcagt ctcagtggtt 3660 Página 2

P201430887 ES 2 553 786 A1 09-06-2014 aacagcataa aatagggttc ttcccaggct ggctcaagtt ttttctttct gtcttttgat 3720   gaggacgtgg ttttcaggct ggtgctggtg tactggaaat tctaggggtg gtacctagaa 3780 ctaaaagtct tttagttctg agggaaggga aactggaaga taaattaagt atatcatttt 3840 tgctgcatat cctggggctt gaggccccat ggtgatgcct cccgctccat tcctgctcag 3900 cgccgcccag gggacactgc ggccctgcct cctcttaagc tcttggcctt cttggggcct 3960 tcactgcccc tgtgcactgt ggccttggac atgaggggcc ttgtgactta cctggccacc 4020 ttcaggcctt aagaaagcta aacaccattt tatatttgac agtgcttttt gtatgatttt 4080 ataccagata agttaaattt tacctttata ctaatgtgct attaatgtta aacttaataa 4140 aatctttttt tttttttttt gagacagagt cttgctctgt cgcccaggct ggagtgcagt 4200 ggcgcaatct cagctcaccg caagctccgc ctcccgggtt cacgccattc tcctgcctca 4260 gcctcctgag tagctgggac tacaggcgcc cgccaccatg cccagctaat tttttgtatt 4320 ttttagtgga gatggggttt caccgtgtta gccaggatag tctcgatctc ctgacctcgt 4380 gatccgcccg cctcagcctt ccaaagtgct gggattacag gcgtgagcca ccgtgcccgg 4440 ccaaacttaa taaaatcttg tagacattat ttattcaatt ttaatgtctg actatagggt 4500 aagattttta tagactcttt ttaagctttt ataatttttg ttaaagagcg ggttagtgct 4560 ttaagaaaaa tctattgtgc ttttaacatc cagttcacag aaaaactgca tgatacccct 4620 ttagctttag ccaatatgtt tacacacaga atttccttta caattaacat tttaaaactt 4680 gcttaaacct ttaaaacaaa atatattttt taacctttta atgtaggtaa aaatccatat 4740 tatgtctcct tataatcctg ttattaaaag tattatttta tttttctgac ataccttgta 4800 tataaactgt ttttttttaa ataattttac attcaggagg cctaattact tttaaattat 4860 acactatttc ttgcataaat tcccttttat agcttttctt acaactttca caatcttcaa 4920 catgtcttaa ctttctgcct gccttttacg ctatttcttt ttctcagttt caccctctat 4980 gtcttccttt gatttctgtc tcttccagtt tctctcttat tctttccctc tgtattttaa 5040 tctctttctg tctcttctct ctcttcactc tcttcatccc ctgcttcctt cttccctcct 5100 gagttctccc gctcctgcag cagcagggcc gggcaatggc accagcccct gggcatgcac 5160 tgccgtcagt ttctctatcc acccccacca ttcccctttt tacttttttt cccctttctt 5220 cctacactta gtttctcggg ctgggtggga tttgcatggc tgcagtccgg ccccggcagc 5280 ccagaggctt ggcagatgcc tgccacaaat tgcaagaatt atgccctctc acctcctctg 5340 ctctcttcct ggcgccgctg tgcttgctgt ttttgctttc tttttttctg acttcctctc 5400 ctagttcttt ttcctgtctg ctggtctttc ctttgtctct gccagccacc tatgctgctg 5460 ttttcccccc tctccttccc cttcccctgg gggaccaacc agcgggagtg aagcttagcc 5520 tttttctttc cctgtgaaga ggggaaaagg gagttttgaa tatatatata tatatatata 5580 tatatatata tatatatata tatattttaa ctactggagg tttgtgtgag gttcaacccc 5640 ctgaaattaa tggaagactt aacccctcaa accaggggtg tcttgccttg cctgccctgg 5700 gaggttgacc tgtttcctcc tttcccccca aaggtccctt gcatacttcc cacttgtgtt 5760 Página 3

P201430887 ES 2 553 786 A1 09-06-2014 gtcctctctg gtcgcccccc caagggagaa ttaggcccct cttagtgtag gcgtgctggt 5820   ataaatccca cagcaggacc tgccctaagc catatgaggt cactacagaa ccggaaccat 5880 ggaggggacc cactcactgt ccagcaggag gacttgtcac cgtccacaca aaccacactg 5940 caagcagggt tgtctgtgat cattcacaca tacacacatt cagccctcca gaatttcacc 6000 accaaggaag tactttacca gcttctgtgg cttctccttc cttggtctgt gcacagagtt 6060 gcagccctgg tatgtgagca tcctttacct taggttgctg gccagtttct tttttttttt 6120 tttttctgca ttgctgagag tccgggttta ttcgtcacac caggtgggtc tcaatttctc 6180 atccctgagg ccactgcagt gaggcagagg agcgtgctcc ctcatgagag aggaacagag 6240 accgcccccg caggagaatg tagccctgta cggattgcca ccaaattgtt tgaaatgctt 6300 gttccccggt gccgtaaaga aacagcagtt gaacataaat ttaatttact cagcaaggac 6360 atttttactt cctgcagaaa ggacacactt gccatcagct ttgccacaag agttcaccca 6420 acaaaggaaa cagggtcatt tataacctga cgcgtccacc ctattgccgt ctctggtttc 6480 cattgactgg gatgggacct cacattctgt atctgtcccg attggctagc aacgtacaac 6540 tttttaaaag aggcaaaggc agaggagaac aaaggaagga agtaatttgt ggaatgctga 6600 gaaaggtaaa aacaccttca aataaggaag aggaacaggc tatgacctaa tgcccgcttg 6660 gaccagtata agcatgccag ggcaaatatt taggctaaat tgtgggagct aagaacctaa 6720 agtagtacat tgctttcttt attactgcta gcagatattt aataatgtta gcacaggtct 6780 ttgaataaat tttgcttcta agagaagtta ctatttattc ctaattagat cggtaggaaa 6840 gtctttgaag aggaacctct actttacaac taaacatcta gaggctcgga atgcctcttt 6900 ctggggatgc agcccagcag gccccagcct catttcccag ccctcactca aaatggagtc 6960 gctctggttc cagcgcctct gacactgaga ggtcatgtca ggaatgggga aactgaggct 7020 cagaggagct atggcactgc acaaagctac acggctccct ggtcttctgt ttctgttgag 7080 tcatgtgaac caaaaagtat cggagatatg tctcagtcaa tttagaaagt ttactttgcc 7140 aaggataagg actcaccagt cctgacaaca tgtgcccaag gtggtcgggg cacagcttgc 7200 ttttatacat ctcagggagg cacaatacat ctgtcagtac atgtaagatt cacattgatg 7260 ccatctggaa ggggggcttt caggtcatgg tagatgtaaa agttttctga ttggcagttg 7320 gttgaaagag ctattatcag tagaaaggca tgtctgggtt aagatactgg ttgtggagac 7380 ctaggtttta ttatgcagat gaagcctcca ggctgcaggc ttcagaggga atagatcata 7440 aatgtttctt gtcggactta aggtctgtgt tgttaatgct ggagggcata acaggcctgt 7500 cccacaccct cttctatcat ggcctgggct agtctttctg gttaaatgtg gagggccctg 7560 gcctattgga ggaagttcat tcagatggtt gggggtacct tccgatgtta tttttggttt 7620 acagtcagga accccctaaa aggcctagat ctctctctgt ccccaggtgc tggactctat 7680 gtctttcatg catctagagt ccagaggcaa aggccaccaa ggctgagagc cgggcacgga 7740 ggccgaggag atggggagcc agggttgctt ttctgggaaa gagggagtga taaaatcagg 7800 catgggctgg ttggtgaggt ccctgtggga ggtgaaggct gggacccaga acagcagaga 7860 Página 4

P201430887 ES 2 553 786 A1 09-06-2014 ctctgtcgat gatgtggaaa gaccgcggct gcagtttggg caggctgagc cagggttggg 7920   tcttgcatgt tgagaggctg gcctgcggtg atgtggccaa agaggaagag ctgggctggg 7980 gtgagtgttg gtcacatggt tgaaactagg tggggagggg agtggtccag gggagagtcc 8040 aggcccagct ctgctgggac ttgccatggg ggtcacgact catctgcagg gaaggtctgg 8100 gctttatctc tgagcacctc tgtgtgctgc tcaccctgaa gtgggggtgg gcctgtgcct 8160 ggcctgtccc ctcatcctgg gagctcccaa tgcccatctg caaggctgtg gacccctcag 8220 gagtggcctg gagcctggct cccattgcca catggtggct gtgtgtgtgg agagggttga 8280 tagtggagtg gtcaggccca ggctgccctg ggggatgaag tgccatcctc tgggtgccct 8340 ggagaaagaa gagaactcag tgagccctgt ctggtacttt cctggaggag ggctcccatg 8400 ctggccctcc acccctctgt cccctgtcac cctgaggcct ctggatttcc tctctgccct 8460 tcccaacctg ccaacttcac gggtttctgg ctgggttctg gggatggccc ctaggggaga 8520 cgggccaggc acaagcgggg ctgtgtcaag gtgggtatgc aggggtagca caagtgtgca 8580 gagcctgggg aggcatgggc aaagcatggc aggcggcggg gcaggggatc ttggaaggtc 8640 acgggctggg gagcagtgtg ggcagcggcc cagaggtggg aaggccgtag cttagctggg 8700 tgtccccttt ctgtcctctg caggtggagc cccctgagct gcccgctgat ctgcagcact 8760 ggatctccta caacgaggcc agcagccagc tgctccgcat ggagagtggg ctcagtgatg 8820 tcaccaagga ccagtgaccg ccaccttcac accgtctgcc ctggccacca tcctgggcct 8880 gggggctgcc cacagatggg cagtctcagc catactctgt tccagctgga gtagcctcct 8940 gaccagcctg gcccaccctg ctccacccac tgggcccccc cagttattga tacccctctg 9000 tgctgggctc cacgctaggc agaaggagga gtggcattgg catcctgacc cagctctgcc 9060 ctcaaggtgg ggatggatgg gcaaaggaga gtcctgcctg gccctacgat gaggccactc 9120 atgtgggcct aggtagggga ggatggtgcc tggagcagag ggacccacaa gtgcctcccg 9180 agcctagatc ctggctcgga ccactgcaag ggccgaggca gggccagacc agagcatcct 9240 gggtacaggc ctgggctctc cagggcctgg gcctgattca ggtgcagtgg gcactcctga 9300 agggtcagag cggcatctgc caggcagccc ctctggcttc cgctgaggtg gttgcaggcc 9360 tggggcagag cctgggtggt cagaggccgg ggctagaggc agatggaagg gaggcatttg 9420 ctgacagagg acggggcacc cgggctcccc actgcagtcg gccttgcctc ctcctcctcc 9480 tctacctcca gtcaggctgg acgggagggt agccttgtgg ctgagagggg tcagactagg 9540 tggcacaggg gctcctggaa agacagcagg cttcctgctg ggcgttccct tgttggaggg 9600 aatagagtgg gggtgggact ctgcaggggt gtccttgtcc actcgcaccc ctcgccgccc 9660 accagggcca tgctctgtga cttgggctga tccccaccct ttctgggcct acagcaccac 9720 aggccgctgt acccccttag agctgcccct ctctggcctg gccggcaggc gtcttcttaa 9780 ctcctctgtc ctctatattc agcatgttcc ttgtcagctg ctgggccggc cctgccttgc 9840 gctagcagag cctctcctgg cagcttctca ggtctcccta atggagacac caggctacta 9900 ggacactggc tggggccacc ccctcctgcc taatgcctca ccttacagct ggggaaactg 9960 Página 5

P201430887 ES 2 553 786 A1 09-06-2014 aggcctggaa tggcccagag tcaccaaggc aaagttgggg ctggtcccag cctgaggctc 10020   cagctgatgc cctcagctcc cagagagggg gtgccccatc tagctgggtg caggggtcac 10080 tgcttgtcag ctcagggccc tgtgcccgct tgcctgttcc cctacatctg tgcctgcaca 10140 tccagaactg cctccttgcc gctgcctcca ggaagcccac cttgagccag agtcaagggc 10200 tgcagcactg cccgatagaa cacgcccgcc ctcactgctg ttcttgcctt acagccacca 10260 tgggaaagct gcaacctttc tgttttattt aaagaaagcc caacattaaa gggttttcat 10320 tgcaagcgtg ctggggaggg ccttgtttct gagctaccac caccaccatc catgcagggg 10380 cggaggtggg accagggaag ctggggcaca ttcccaagat gggtgtctgg catggggggc 10440 tatccaggtt tgttgggctc ccgtgaactt agggatcagg ctggcagggc agggcttgtc 10500 ctcatcccat ggggcatagg actgaggcca agaaggtgct gtccaaagcc ccctggggag 10560 ccagcccttc ctgctccggc cctcctggtt cccagctctc gaggcttgca gccccatcta 10620 cagatgccag cgccaggttc ccggtttccc tccttcaggg attaccctgg cggtcatgcc 10680 tcagactctg ggtctggccc tccaggctcc cagagcctcg ggcagggtgc tggtagccat 10740 tgggggcaga ggtcaatgga ctggtgggtg gacaggaggc agagagagca tgggggctgt 10800 tctgcaggcc cttcaaaagg ggtggggaga agtgggaccc tccgggacat aaagttgagt 10860 gaggcggggt gtggccacgt ccatgctgtg accaccttcc tgggagggtc cagaaggctc 10920 tgagg 10925 <210> 2 <211> 28769 <212> DNA <213> Homo sapiens <400> 2 ggaaaacaat cccttgacag cgtttccatg aaaacatggc ccttgtctct ggaagagctt 60 gtgcccagaa cggtccatta tcatgccctg gctctatttt cacgccaacc ctatagggtc 120 tctatgatct cattttatag atggacagac tgaggctcac atatagcaag cccaaggcgg 180 ggactgaatg tgacgccagg tctgtggacg tcatgacctt tattctccac aaccctcaat 240 gacatccctg tgagatccaa aaccaggatg gcaaaaccca cgttgcagca gaggaaactg 300 aggctaaggt ctcttgggtc ccaaaccagg tcctaagtag ccaagtccgc ctggtggcac 360 agcccgggtt ttatacatgg ggaaattggg cggcgcatct ggcggaggtc tcagtggtag 420 gaggcgcctg gaggaagcgc gggttcctaa ccctaacgct acccctaaca tcccttccac 480 gcgctccgag cgctatgtgc ctttaagatc ggtgcggggg cggggcgtcc tgggtagggc 540 tgcaggtgac gtcactccgg gccttgggac tcggagagcg tctggaggcg gggcctggac 600 ttcacgcccg gcgcgctcct cccctttaag gcgcgcggcc gggcggggcc cctatgaccc 660 ctttaaggcg cggccagagt cctcccgcag aaaaacgact taaaggagac gcgtggcgcg 720 atggcggcgg ccccacgcgc gggccggcgg cgcgggcagc cgctcctggc gctgctgctt 780 ctgctgctgg cgccactgcc gccgggggcc ccgccgggcg ccgacgccta cttccccgag 840 gagcgctgga gcccggagtc gcccctgcag gcgccgcgcg tgctcatcgc gctgttggcg 900 Página 6 cgaaacgcgg cccacgcgtt gcccaccacg ctgggcgcac tcgagcggct gcggcacccg 960 cgggagcgca cggcgctatg gtgagtcgag cccgctgtcc ccatcaggcg ggtcacgcga 1020 gcccctgctt gctgtcccca taggggtggg tccacgcgag cccctgcccg ctgtcctctt 1080 ctgggcgggt ccgcgcgtgc ttcctgctcg ctacccccat cgggacggtt ctacgcatgc 1140 ccctgcccgc tgcccccatc gggacgggtc cacgcgtgcc ccctgcctgc tgtcctccca 1200 tggggccaga cacagccctc cccacaacac aagcgggacc gagttcctcc tgctggctcc 1260 tttggggtgg gctgggcacc gcttctgcct gctggaccct actagggcag ctccggcctc 1320 actaactggg gctctaactc cctctggggc acgtacacct ccaaaggacg gagcccagag 1380 cccccactgg ggcgttgcca gaggccacat ctaacagcaa gcctttctgt gccggctgct 1440 gcccttaagc ttgaactcag cctggctcca ggccccagtc aaacccctgc cctcagaccg 1500 gcgtgggtgg agtccaggac cagatggccc aggaggaagt ggatgctttc ttggtaggga 1560 atggggcaga gctctgaaga aacctttgac tggtgacttc tcactccctg cctcagtttt 1620 ctcaaatgga aaatgggtcc gggtgcagtg gctcacgcag taatcctagc aatttgggag 1680 gccaaggtaa gcgggtcact tgagctcagg agttcgacac cagccttgcc aacatggcaa 1740 aaccccgtct ctagaaaaaa aatacaaaaa ttagccaggt gcggtggtgt gtgcctgtag 1800 tcccagctat tcaggaggct gacgcaggag aatcgcttga gcccaggagt tcgaggctgc 1860 agtgacctat gattgcacca ctgcactcca gcctgggcta cagagtaaga cctgcctcta 1920 aaaaaagaaa aagaaaagaa aatgagcgta ttaatataat tctctttttg ggtttgtctc 1980 tgaagattat ccagttaatg gatgtggagc ccttgggtct ggcatgggct tggctctcag 2040 tgattttatt atcatgatta ctgtcattgc tggtgttatt gtcaacttaa tttattgggc 2100 agaattagct tttggcacta cggtcaaact aaactcccaa atgtcgcttt tccttccacc 2160 tgatttctca gtctggataa tccaaataca caattggtac ttaacaaatg tttgttgaat 2220 gaataattga ctgcagccca ctgaagtggt gtggctcaca ggagaagatg aaggcagggt 2280 aagggattta tgagatatac tttgagatat actttttttt ttctctcaga cggaatcttg 2340 ctctgtcgcc caggctggag tacagtgaca cgatctcagc tcattgcaac ctccgcctcc 2400 gggttcaagt gattctcctg cctcagcctc ccgagtagct tgggattaca ggtgcgcacc 2460 accatgcctg gctaattttt gtatttttaa tagagtcagg gtttcaccat tgtggccagg 2520 cttgtgttga tctcctgacc tcatgatctg cctgcctcgg cctccctaag tgctgggatt 2580 acaggcatga gccacagcgc cctgctgaga tatacttttt tttttgatac agggttttac 2640 atctgtcgcc caggcgggag tgcagtggtg caatcctagc tcactgcaac ttccccctcc 2700 tgggctcaag tgattctcct gcctcagctt cttgagtaac tgggactaca ggcgtatgcc 2760 actgcgccca gctaattttt gtattttttc tagagatggg gttttgccct attggccagg 2820 ctggtctcga actcccgagc tcaagtgacc tgcccacctc ggcctcccaa catattggga 2880 ttacaggcgt gagccattgc acccagctgg tttctgatat atacatttca ttttttaata 2940 ttttttattt atttattttt tgagactgag tctcgctctc gttgctgagg ctggagtgca 3000 Página 7 gtggcacgat ctcggctcac tgcaacctcc tcctcccagg ttcaagcgat tctcctgcct 3060 cggcctcctg agtagctggg attacaggtg cccgccacca cacccagcta attttttgtg 3120 tttttagtag agatgggatt tcaccatgtt ggccaggcta ggctcaaact cctggcctca 3180 agtgattcac ccgcctcggc ctcccaaagt gctggaatta caagcgtgag ccaccatgcc 3240 cggcctaatt tttgtatttt tagtagagat ggggtttcgc catgttggcc aggctggtct 3300 caaactcctg acctcaggtg atacacccgc ctcggcctct caaagtgctg ggatgacagg 3360 cgtgagccac cgtgcctggc ctgatctata cattacaaaa attgccgtgt gcggtggctc 3420 attcctgtca tcccagcact ttgggaggct gaggcaggtg gatcacctga ggtcaggagt 3480 tcgagagcag cctggccaac atggcgaaac cccatctcta ctaaaaatgc aaaaattagc 3540 tgggcatggt ggtgggcacc tgtaatccca gctactcggg aggctgaggc aggagaattg 3600 cttggacctg gtaggcggag attgcagtga accaagattg tgccactgca ctctagcctg 3660 ggtgacagag caagactctg tctcaaaaga aaaaaaaaat taagtgacac atatttgtta 3720 gtgaatgtgg tttgcaagat cttagatgct cagtaataaa acagccaatc actaatgggt 3780 ctttccaaaa tcagcttgtt taatccttcc acttcccagt aaactgggtc ctgttcccac 3840 ccccatgtta cagatgagga aactgacatg gaaagggaga aatgggccgg gcgcggtggc 3900 tcacgcttgt taagtccagc actttgggag gccaaggtgg gcggatcacg aggtcaggag 3960 atcgagacca gcctggccaa catggtgaaa ccccgtctct actaaaaata caaaaaaatt 4020 agccgggtgt ggtggcgggc gcctgtagtc ccagctactt gggaggctga gacaggagaa 4080 ggcgtgaacc cgggaggcgg agcttgcagt gagccgagat cgcgccactg cactccagcc 4140 tgggcaacag agcgagactc tgtctcaaaa aaaaacaaag gaaagggaga agtgtcctgt 4200 ccagggatac atagctggtg ggaggccagt tggggatggt ggtccttgac ttgcctcact 4260 gctgcctggt cctgcctcag tctccccaag tacgctgcct gtcccctctc cctgcagggt 4320 ggctacggac cacaacatgg ataacacgtc aactgtgctg cgggagtggc tggtggccgt 4380 gaagagtttg taccattccg tggagtggcg gccagcagag gagcccaggt gagcatcttt 4440 cccctgctcc tagtctgatt gggctttgcc tctgctcaca caccctctat ggctccccat 4500 tgccccagaa caattacagg ccctcagtcc ctgcctccag cccagccagg cagcattaag 4560 ctactctgag cctccctcag ctttacaaat aggccataat cctcttctca gacctttgcc 4620 caagccgttc cctgtaccta gaattctttc actccctttt tcttctgggg acgcccactg 4680 ctttgttccc tggctcactg actcagtctt ggtcccagca ctggctttgc tgtttatcta 4740 ctccctaaag ccctgggcag catggactcc ctgcccccac ccagttcctt tctgggtttt 4800 tgtttttttt ttgagacagg gtctcactcc ctcacccagg ctggagtgca gtggagtgaa 4860 cacagcttac tgcagccttt aactcctggg ctcaagccat cctcccgcct cagcctcctg 4920 agtagctggg actacaggca catgtaacca tgcctagcta atgtttttgt attttttgta 4980 gagatagggt ctcactgtgt tgcccaggct ggtctcaaag tgctggcctc aagcgatcct 5040 cccacctctg cctcccaaag tgctgggatc gcaggcgtgg gccactgcac tggaccccac 5100 Página 8 tgagcttcct tccttccttc cctccagtgt gcctcgggct ttcttccctc caggcctttg 5160 cacaggctgt acctccggcc aggaacattc tccccacttc tctttcctcg tcgtttactt 5220 tttcccatcc ctcagatcag cttacacgtc ccctcctcca ggaagctctc tctgagtacc 5280 ccgaaggcag ctcaggccct cgctgggctt tgatagtgcc ttgtgatgtc cacatcacag 5340 ctgcctcccc ataggtccta cccggacgag gaaggcccga aacactggtc tgactcacgc 5400 tacgagcatg tcatgaagtt gcgccaggca gccctgaaat cagctcgaga catgtgggct 5460 gattacatcc tggtaagttt ctcagccggc cggatatgga tcacaggcag gtctgggtat 5520 ccccagggaa ggcggagcag caggatgcca ggaccatcct taatgttgtt ttgcagaagg 5580 gtaaactgag gcttagagag gggagatgag ttgcttgagg tgatatggtt ggtcagtgga 5640 ggaggagctg ggattcattt gatcctcagc actaggaatg aatgggcttt tctgtcccca 5700 gttgtcccct gtgtttggac acttgggtca agtccatttt tattttttta tttttttgag 5760 acagagactc actctggtgc ccaggctgga gtgaagtgcc gcaatatcgg ctcactgcaa 5820 cctctgcctc ctgggttcaa gcgattcccg tgccacagcc tcctgagtag ctgggaccac 5880 aggcacccac caccacgccc ggctaatttt ttatttttat ttttgtggaa gccaggcatg 5940 gtggctcatg cctataatcc cagcacttta ggaggccaag gcgggtggat cacttgaggt 6000 caggaggtcg agaccagcct ggtcaatatg gtgagactcc atctctacta aaaatacaaa 6060 aattagccgg gcgtggtggc aggtgcctgt aatcccggct acctgggagg ctgaggcagg 6120 aggatttctt gaacctagga ggcagaggtt gcagtgagcc gagatcgtgc cactgcactc 6180 cagtcactgg gcgacacagt gagactccat ctcataaata aatacataaa taaatatttt 6240 taaaaaataa caaataaaaa atatttttgt agagacgggg tcttgctatg ttgcccaggc 6300 tggtctccaa cccctgggct caagtgatct tcctgcctcg gcctcccaaa gtgctgggat 6360 tacaggcatg ggccaccgtg cctggccgtg tcacgtctgt ttttatcacc atcatatgta 6420 atggccaaac ctttgggtca cttccaagaa gcaggaggaa ggggtcaggg gctggggggt 6480 ggtggccaca ttgaattgct gaggcctgac ttgcacttcc tcctcctgtg gggacattgt 6540 ctcatgggga agggaacagt tgagtctttt tatttttttc tcgagccaag atcacgccac 6600 tgcactccaa cctgggccac agtatgagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa 6660 aaacagactt ataggttgaa tattactatt attttttaat ttgtataaac ttatggagca 6720 caagtgtaat tctgttacat gcatagattg tgaagtggtg aagtcagaga ttttggggcg 6780 tccatcccct aaataatata cattgaaccc attacacagt tttctatgat caaccccaaa 6840 tgttatttca gccttcatac ttttctatat tctcctgatt ttcttttttc ttgttttttg 6900 agacagagtc tctgttgccc aggttggagt gcagtggcac aatctcggct cactgcagcc 6960 tcctcctcct gggttcaagc aattcttctg cctcagcctc ctgggtagct gggattacag 7020 gcccccgcca tcatgcctgg ctaatttttg taattttagt agagacgggg tttcgccatg 7080 ttggccaggc tggtctctaa agtcctgacc tcaggtgatc cagctgcctc ggcctcccaa 7140 agtgctggga ttataggtgt gagccaccac atccagccca tctcttaaaa caaacaaaca 7200 Página 9 aaaagcagaa aagaaaaagc aaagagtcaa gtgagcaaag tgattacgat gcagtggtgg 7260 ctagaggtcc aactacacag gccagtggag gcacttggtg tctacttgga ggggaatggg 7320 gagccatgga gggtgtgtga gcaggggagg tctgtgttct gatttgagat tttcagaagc 7380 ctctgtggac caggcgcggt ggctcatgcc tctaaattca gtactttgag tggctgaggc 7440 aagtggattg tttgacttca ggagtttgag accagcctgg tcaacatggt gaaaccctgt 7500 ttctaccaaa atataaacat tagcttggca tggtgatgcg cgcctgtaac cccagctact 7560 tgggaggctg aggcaggaga atgtcttgaa cccgggaggc agaggttgca gtgagctgag 7620 attgcaccac tgcgctccag cctgggcgac agagtgagac tatgtctcaa aaaaaaaaag 7680 ccacacacta gcaggaagct ggagtagagg cccaagcagg gtatcagcga ttgatggaca 7740 ggcctgcatg gggtgggggc cgtggagaaa ggcagggggt tcaggatgcg tcacgaggtg 7800 aaggagacag gttctgcttt gacactggat gtgaaggtgc cagggagaga ggaacgggga 7860 cagtgccaca tctagggagg acggatggag ctcctgaggg gaccctttcg cttggtgcct 7920 tatcagacca ttttataggt gaggaaacag gctgacggag gggacatctt gcctggtggg 7980 gtgtcagaac tggcaaggag gcagagaggt ggatctggag ccttccagag ccttctgaca 8040 caaagctgcc ttgtcctgcc tctaggattt tgcttttgtg gtttgaggtt gcctggcttt 8100 agcttttttt tccctcagca aaccggggtg gaactcaaag tgctggttca aaactcaaag 8160 tggcttttga cacaaaataa tattttcgtg tttctttttt tttttttttt tttttgagac 8220 agtgtctcac tctgtcgccc aggctggagt gcagtggcgc gatcttggct cactgcagcc 8280 tccacctcct ggggtcaagt gactctcctg cttcggcctc ccaagtagct gggactacag 8340 atgcttgcca ccatgcccgg ctattttttt ttttgtgacg gagtctcact ctgtcgccca 8400 ggctggagtg cagtggtgcg atctcagctc actgcaagct ctgcctccca ggttcatgcc 8460 attttcctgc ctcagcctcc tgaatagctg ggactacagg cgcccgccac aacacccggc 8520 taattttttg tatttttagt agagacaggg tttcaccgtg ttggccagca tggtctcgat 8580 ctcctgacct cgtgatccac ccggcttggc ctcccaaagt gctgggatta caggcgtgag 8640 ccagcgcgcc tggcccgact aatttttttt gtatttttgt agagacaggg tttcactatg 8700 ctgaccaggc tgatctcgaa ctcctgactt caggtgatcc acccacctcg tcctcccaaa 8760 gtactactgg gattaccggt gtgagccact gcgcctggtc acaaaattat atttttgtaa 8820 ctggggactt tggaacccat attggaatgt gaaatagttt gtctaatgtt ttaaaatgat 8880 tgtttgaagg tccccctttc tctctctttt tacaaaagct atggatgtta cttgcaggta 8940 aaaaaaataa ataaaaatat acgagctggg tgtgtctcac gcctgtaatc ccagtgcttc 9000 aggaggccaa tgtgggagga tcatttgagg tcaggagttc aaaaccagcc tgggcaacat 9060 agtgagaccc cccccatctc tacaaaaact aacaaaaaaa aaaaattagc caggtgtact 9120 ggtttgtgtc tgtagtccca gctaattggg aggctgaggt gggaggattg cttgagccca 9180 ggagtaggag gctgcaatca gccatgattg tgtcactgta ctccagcttg ggtgacagag 9240 cgagaccctt tcttaagctt cgtatatgtg tatgtgtgtg tgtatgtgtg tgcgtgtgtg 9300 Página 10 tatacatata tacatatata cgtgtatatg tatatatatc tatatatgta tataaacata 9360 tatacgtgtg tgtgtgtata atatagatat acatatgaaa caagaaagaa aaacatctac 9420 tttttttttt tttttttttt tgagatggag tctcattttg tcacccaggc tagagtgcag 9480 tggcgccatc tcggctcact gcaacctctg ccttctgggt tcaagcaatt ttcctgcctc 9540 agcctccgga gtacctggga ttacaggtgc ccgccaccat gcctggctaa gtttttgtat 9600 ttttagtgga gatggggttt cgccatgttg gccaggctgg tcttgaactc ctgacctcaa 9660 gtgatcacct gcctcagcct cccaaagtgc taggattgca ggcgtgagcc accgcccctg 9720 gccagcatct aaattttaat tgtatctcct ggagagattc actttctcct ctttcttgtt 9780 tgttttaatt gaagtcagtt cacatatata tttatttgtt ttgcaaccac cacctctaat 9840 tctagaacat tttcattccc cagaaagaaa accctattcc catcagcagt cactccccaa 9900 ctccccattc ctctccccta ggctctggca gccactaatc tgcttcctgt ctacggattt 9960 gtcaatggaa tgtcacacta tatggcgttt cgtgtctggt ttctctcact cagcattgag 10020 ttttcagggt tcattacagc ctggatcagt gcttccttcc tttgtatggc tgactcttat 10080 tccgttgtct gggtggacca cgttatgttg atctcctcat ccgttgatgg acacacttca 10140 gtcacttcca ccttttttgg ctgttgagac tttttttttg agacagagtg ttgctctgtc 10200 gcgcaggttt gcagtgcagt ggcacgatct cggctcactg caacctccat ctcctgggtt 10260 caagcgattc tcctgcgtta gtctcccgag tagctgaaat tacaggcatg tgtcaccatg 10320 cccggctaat tatttttatt tatttttatt tttagtagag acggggtttc accgtgttgc 10380 ccaggctggt cttggactct tgacctcatg tgatctgcct gccttggcat cccaaagtgc 10440 taggattaca ggtgtgagcc actgcacccg gcctggctgt tgggattctg acatgaacat 10500 gagcgtacaa agacctgttt gaattatctg ggcatggtgg tgcgcgcctg tatttaatcc 10560 cagctactca ggaggctgag gcaggagaat catctgaacc taggaggtgg aggttgcagt 10620 gagccgagat cacaccactg cacttcagcc tgggtgactg agcaagactc tgtctcaaaa 10680 acaaacaaac aaacaaagaa gctgtttgag tcctttcttt caattctctt ggttcatacc 10740 taggaatgga attcctggat catgtagtaa ttctatgttt agctttttga ggaactgcca 10800 cagtgatctg gctgtttgtt ctgcattaat attcaaaggt cacagattca aacatccaga 10860 gggaccggat ggggtgtgta acatgaccac agggcttgtc ctaagaccca gccacctccc 10920 ctctgcaact gaaggttgcc atgtggaaat ggtattctca cgttgccagg ggatactgga 10980 attctagttt ttgttgttgt tcatggcagt taatccaaat attctaaacg atactgcctg 11040 ggtaacagaa agcatctctg tggaccagca gtaaaagaaa aaaaatccag accgggcaca 11100 atggctcaca cctgtaatcc cagcactttg ggaggccgag gcaggcgtat cacttgaaat 11160 caagagttcg agaccagcct ggccaacctg gtgaaacccc atctctacca aaaaatacaa 11220 aaattagcct gacgtggtgg catgtgtctg taatcccagc tacttgggag actcagggag 11280 aattgcttga acatgggagg tggaggttgc agtgagccga gatcacgccg ctgcactcca 11340 gcctatgcaa caggagacgc catctcaaaa aaacaaaaac aaaaacaaaa aaccttctgg 11400 Página 11 tagttctgtg atatatcatg acttctgtgt ctttacatcc tggtagaggg ggaacgtccg 11460 gacctaatca ttttctatgt gtgattttat atatatatat ttaattttag tctaggtgca 11520 gtggctcaga cctgtaatct cagaactatt gtaggccatg gggaggatcg ctttgagccc 11580 aggagttcaa aaccacccta ggcaatgtag agggatccta tctctacaaa cataaaaata 11640 aaaatgaaaa cattatctag gcatggtgac gtgtgcctgt acgctcagct acttgagagg 11700 ctgagatgag aggatcactt gagcccagaa actccaggct gcagtgggct acgattacac 11760 cattgcactt cagcctgagt gacacagcaa gatgctatcc ctttaaaaaa taaaaaatga 11820 agaaaaagta aaatagtagg ccaggcatgg tggctcatgc ctgtaatccc agcactttga 11880 gaggccgagg tggacgaatc acatgaggtc aggagtttaa aaccagcctg gccaacatga 11940 tggtaccctg tctctattaa aaatacaaaa agttacccgg gtgtgatggt gcacggctgt 12000 agtcgcagct actcgggagg ctgagacagg agaatcgctt gaacccagga ggcggaggtt 12060 gcagcgagct gagaccatac cactgcactc cagcctgggt gacagagcga gactccgtct 12120 caaaaaaaaa aaggttttgc taccttcttg ctcattggtt gttcatttat ttctcagggc 12180 tatctcagtg cctagaattt tctttgaagg aactgaagac ctttgcttta tttccatgat 12240 ccaggggatc ctgcaggccc ccaaaacggg gtccctgctt catttcatcc ggtgtagggg 12300 gtgcttccag aggtctttgc cagaccccca gggcactggc ctttgcccca gctgttctga 12360 atggtagcct gacctggcag cccatgctga tgctttgtgg ggtgttctgc agtttgtaga 12420 tgcggacaac ctgatcctca accctgacac actgagcctg ctcatcgctg agaacaagac 12480 ggtggtcgcc cccatgctgg attcccgggc tgcgtactcc aacttctggt gtggaatgac 12540 ttcccaggta gagtgagggc ctggggactg tggggactgg gctgagcagg ggggtgccgt 12600 ggctagagtg taacttactg tcacacaacc tcgtggtgtg tgttttacaa aaatcatcat 12660 ggaagctggg cacggtggct cacacctgta accccagcac tttgggagac tgcggcaggc 12720 gggttgcctg agctcaggag tttgagacca tcctgggcaa catggtgaaa ccccatctct 12780 actaaaaaaa aaaaaaatta cagaaattag ccgggtatgg tggcacatgc ctgtcctccc 12840 agctgctcgg gaggctgaag catgagaatc acttgaaccc aggaggcgga agttgcagtg 12900 agccgagatc acgccactgc actccagcct gggtgacgga gtgagacttg gtctcaaaaa 12960 caaaacaaaa caaaaactca ttatggtaat ctttaaacag ccctctgagg ccagacagga 13020 gggaagaata gagggtcctt gattgtcccc caccatgcta ttccagaggt ggaaacagaa 13080 acacagagag gaagtgactt gcctaaagtc acacagctag caagtggtgg tgtcaggatg 13140 ggacttcagg catggcttga tccaggtgtt tggataactg tctttctcca tcctttgggt 13200 gggttcattc tcagacagct tgagagtgat cccagcagcg tctagccatc atccattctg 13260 attgggccat tgctagtctc ctctccacac tacctctgaa ctcattactg aagctgggaa 13320 aatacaaggc tctttcttat tggccatgcc tggccacagg tcccacactg ggcttgagtc 13380 tggggtcctg ggaccacagg cgcacactgc tgtgcctggc tgtctgtctg gtcctgtttc 13440 atgccgccca ctatcacggg tctccatcct cacctttcaa gacccctacg cggaactctc 13500 Página 12 gctctctccc cacagggcta ctacaagcgc acacctgcct acatccctat ccgcaagcga 13560 gaccgccggg gctgctttgc agttcccatg gtgcactcga ccttcctgat cgacctgcgg 13620 aaggcggcgt ccaggaacct ggccttctac ccacctcacc ctgactacac ctggtccttt 13680 gacgacatca tcgtctttgc cttctcctgc aagcaggcag gtacgtacat gaggggtctg 13740 ccatcgcagg ggcatctgcc tggttctttg ggttttgcac taagccagtt cagaacacac 13800 tgaagattca cagaacccaa acaatgcagc gcagggctga cttcaggtgc agctgtatct 13860 aggtgttcag ataatgtctc caggaccccg tttctctcca gccctggctt tgctggttag 13920 cttcattccc tagctcttta agatctattg gttggtcagg cagagtggct tatgcctgta 13980 atcccaacaa tttggcaggc taaggcgggt ggatcatttg aggtcaggag tttgagacca 14040 gcctggccaa catggtgaaa ccccatctct actaaaaata caaaaattag ccggacgtgg 14100 tggtgctact ggggaggctg aggcgggagg atcacttgaa tatgggaggc ggaagttgca 14160 gtgagccgag atcatgccac tgcactccag cctgggcaac aaagtaagaa tccttctcaa 14220 gaaaaaaata cctattgatt gcatgttact attatttttt aatttgtgta aatttatgga 14280 gcacaagtgt aattttgtca cgtgcataga ttgtgaagtg gtgagtcaag agattttagg 14340 gcatccatcc ccaaataata tacattgaac ccgttacaca attttccatg atcaacccca 14400 aatgttattt caatcttcat acttttctat attctcccaa ttttcttttg tttttttttt 14460 ttgaagtaga gtcttgctct gtcacctagg ctagagtgca gtggtgcgat ctcggctcac 14520 tgcaacctct gcctcctggt tcaagagatt ctcctgcctc agcctcccaa gtagctggga 14580 ttacaggcat acgccaccat gtctggctca tttttatatt tatagtagag acagggtttc 14640 cccaggttgg ccaggctggt ctcaaactcc tgaccccagg tgatccgccc acctcggcct 14700 cccaaagtgc cgggattaca ggagggagcc actgcacctg ggccattctc ctaattttct 14760 acagttgagc atatattaat tgtttaattg ggaaaacaaa tatttaaaga gacagcacag 14820 cctcatgttg acttgttgtt tactggaaac cagaggttgg caaactgacc tgcaggccaa 14880 acctggccca ctaattactt tttttttttt tttttttttg agacggagtc tcgctctgtc 14940 gcccaggctg gagtgcagtg gcccgatctt ggctcactgt aagctccgcc tcctgggttc 15000 acgccattct cctgcctcag ctttccgcgt agctgggact acaggcacca gccaccaggc 15060 ccggctaatt tttgtatttt tagtagagac ggggtttcac tgtgttagcc aggatggtct 15120 tgatctcttg accttgtgat ctgcccacct cggcctccca gagtgctggg attacaggcg 15180 tgagccaccg cgcctggccc cactaattac ttttatatgg ccacaagcta acaacaactt 15240 ttatatttta tttttatttt tttagagaca cagtcttact ctgtcaccca gcctggagtg 15300 cagtggtgtg atcgtagctc actgcagcct caacctcctg ggctcaagca atcctctcat 15360 ctcagcctcc agactggctg gggctatagg cacctgccta catgcccagc taattgaaaa 15420 aaaaaatgtt tttgtagaga tggggtcttg ctatgttgcc cagactagac ttgaactcct 15480 ggccttaagt gatccttccc acctcagcct cccaaagcgc taggaataca aacgtgagct 15540 acggtgcctg gccaacaatt tttacatttt tattatttat ttatttattt gacacagggt 15600 Página 13 ctccctccgt tgcccaggct ggagtacagt ggcatgatct cagctcactg caacctccac 15660 ctcccaggtt caattgattc tcctgcctta gcctccctag tagctgggac tacaggtgtg 15720 caccaccacg cctggctaat ttttgtattt ttagtagaga tggggttttg cctgttggcc 15780 aggctggtct cgaactcctg acctcaggtg attcacccgc ctcagcctca caaaatgctg 15840 ggattacggg catgagccac cacacccggc caatttttac atttttaaat cactggggaa 15900 aagaatcaaa agaagaagaa tattgtgaca catgaaaact gtatgaaatt cagatttcat 15960 tgcccatcaa taaagtgtca tcagtaccca gccaagccca ttcatttaag tgtcgtctgt 16020 agctgctttc aagtgccaca ggcagaacag agtcattgag atagaaaccg tctggcacac 16080 aagcctaaaa tacttaccac ctggcccttt atagaagaaa ttgaccaatt aaaattaaaa 16140 gaggccgggt gtagtggctc atgcctgtaa tcccagcact ttgggagggt gaggtgggtg 16200 gatcacatga ggtcaagagt ttgaggccag cctggccaac atggtgaaac ccgtctctgc 16260 taaaaataca aaaattggct gggcatggtg gtgggtgcct gtagtcccag ctacttggga 16320 ggctgaggca caagaattgt ttgaacccag gaggcagtga acggagatca caccactgca 16380 atccagcctg ggcgacagag cgagactctg tctcaaaaaa aataaataaa ttaaattaaa 16440 agagcatcat tgagtttttt agtctaaaaa agatacacac ttggctgggc tcagtggatc 16500 acttgaggtc aggatttcga gaccagcctg gccaacgtgg tgaaacccca cctctactaa 16560 aaaaaaatac agaaattagc tgggtgtggt ggcgggtgcc tgtaatccca gctacttggg 16620 aggctgaggc aggagaattg cttgaacccc agaggcggag gttgcagtga gccgaggtgg 16680 caccactgaa ctccagcctg ggcgacagaa cgagactctg tctcaaaaaa aaagatacac 16740 actcatcaaa atttaaacca tccagaaaag gatagatgta gaaggaagta acttaactca 16800 cattttgtca aactttcctt tttgtgcctc aacatgcatt tttactgttt tttttttggg 16860 tttgtttttg agacagggcc ttgccctgtt gcctaagctg gagtgcagtg tgccatcata 16920 gctcatggca gcctcaagtc tcctgggctc aagtgatcct cctgccacag cctcccgagg 16980 agctgggacc ataggcaggt accaccattc ccagctaatt ttaaaattat ttgtagagcc 17040 gggcgtggtg gctcatacct gtaatcccag cacttcagga ggccaagaca ggtggatcgc 17100 gaggtcagga gatcgagacc atcctggcta acatgatgaa accccgtctc tacaaataca 17160 aaaaattagc caggcatggt ggcatgtgcc tgtagtctca gctactaggg aggctgaggc 17220 aggagaatca cttgaacccg ggaggcggag gttgcagtga gccaaggtag tgccactgca 17280 ctccagcctg ggagagtgag actctgtctt aaaaaaaaaa aaaagttgtt tgtagatata 17340 aggtcttgct ctgttgccca ggctggtctc agacacctga cctcaagcga tcctcctgcg 17400 ttggcctcct gaagccgtgg gatggaaggc atgagccact gggcctcgcc tgtttttaca 17460 tttgtctgtt gcttccctgc ccactgcaga ggttcagatg tatgtgtgca acaaggagga 17520 gtacggattc ttgccagtgc cattgcgcgc ccacagcacc ctccaggatg aggccgagag 17580 cttcatgcat gtgcagctgg aggtcatggg tgagtctgcc tgcacaccgc cctgggaggt 17640 gccaggttgc ctccctttca ctgatgtctc aaatccgtcc catgagcact gactgagtgc 17700 Página 14 caggcagatg caagtccctg tggggggtgc tgggtgcaac ggcacgtgtg aacgaggtgg 17760 agggttgtgt ctgctctcac agagtgctgg tttgcaggta gctgtacaca gcatgcttgg 17820 ggttgtcggg tgggcttcct ggaggaggtg gcattaaggg gcaggttgag taggagttca 17880 ccataaaggg gattgcagca ggaggtggta gtgtgggcaa aggccgggag gctggaaggg 17940 acgtgaacct ggggaacagg caaggtcagt gatcccctgg ggctggtatc cagggccagg 18000 gtggatggcc tcagagacca ggctgaggaa gggaccttcc ccctgaggac agtcaggagc 18060 tatagaggac atgaaaactg agaggacagc aagttttcac taaagaactg catgtatagg 18120 ccaggcatgg tgactcaaac ctgtaattcc agcactttgg gaggccaaag taagaggatt 18180 gcttgagcct aggagttcaa gatcagcctg ggcaacatag tgagacccca tctctatatt 18240 aaaaaaaatt ttggccgggt gcggtggctc atgcctgtaa tcctaacact tcgggaggac 18300 gagacgggcg gatcacaagg tcaaaagatg gagaccatac tgaccaacat ggtgaaaccc 18360 tgtctctact aaaaatacaa aaaaaattag ctgggtgtgg tagcgaatgc ctatagtccc 18420 agctacttgg gaggctgagg caggagaatc acttgaacct gggaggcgga ggttgcagtg 18480 agccgagatc gtgccactgc acttcagcct ggcaacagag tgaaactccg tctcaaaaaa 18540 aaaaattttt ttttaattag tccgacatgg tggcacatgc ctgtattcta gctactcagg 18600 aggctgaggt gggagaatcc tttgagccca ggagttggag gccgcagtga gccataatcg 18660 tgccactgca ctacagcctg ggcaatagag taagtctgtc tcaaaaataa taataataaa 18720 aaataattat cccagctctt tgggaggcca aggtgggcgg atccctggaa cccagtagtt 18780 tgagaatatc gtgggcaaca tggtgaaacc ttgtctttac caaaaaaaaa taacaaaaat 18840 tagccaggcg tgatggcaca cacctgtggt cccagctact cgggaggctg aggcgagagg 18900 atcccttgag cccaggaggt cgaagctgca gtgagccaag attgcttcac tgcactccag 18960 cctgggcagc agagccagac cctgtatcaa taaataaata aataaaactt taaaaaaatc 19020 catgaactat gaaaccagca gccgtccctc taaaactgga ggagcacgca gggctgagct 19080 gtaattgagg ttgtctaggg atgatgctcc catctcagcc attgctaatg tgggcctcgc 19140 cctgcactgg gcgcagaaag ccctgccaaa gccactgcca ttcccaccac tgcgtagatg 19200 gagactgggt gggaggggtg aggcctctgt cccggggctc agtttcccca gccttaccga 19260 tttctgaacg agtctatctg cggctccccc tggtggctca agatggaata gcaccctgcc 19320 ctttgtgttt tggggagact tttttttttt ttttgagacg gtgtctcact ttgtcaccca 19380 ggctggaatg cagtggcgca ttctgggctc acttgaaacc tccgcctcct gggttcaagc 19440 gattcccctg cctcagcctc ccgagtagtt gggattacag gtacctgcca ccacacctgg 19500 caaattttgt atttttagta gagacggggt ttcaccatgt tagccaggct ggcctcgaac 19560 tcctgtcctc aggtgatcca cctgcctcgg cctcccagaa tgctgggatt acaggcgtgt 19620 gtcactgcgc ctggcctggg ggagactttt gagtcttttt gaggtgacac ctggagactg 19680 cacaatcact ggggcaggcc ccccacaaca cccaagagtg gcatacttag gtgtccaggt 19740 cccacccggc tacagttggg ggtggtgggt ctccatttat caccaactcc catcagaaac 19800 Página 15 gggcctgaga agcgtctctg tggctaccag agttttccca gtttaagttc tcacatatat 19860 ttgtgttgtc atttcctttt tttgagacag agtctcgctg ttacccaggc tggaatgcag 19920 tggcaaaatc acagctcact gcagcctcaa cctccttgac tcaagcgatc cttccacctc 19980 agcctcctaa gtagctgaga ccacaggtgc atgccactac catgctcagc taatttgtta 20040 atttaggttt ttggtttttt tggtttttat ttttttgaga tggagtcttg cactgtcgcc 20100 tgggctggag tgcaatggtg cgatcttggc tcactgcaac ctccgcctcc caggttcaag 20160 tgattctgcc ccaccttccc aagtagctga gtttaacagg cgcttgccac cacgcctggc 20220 taattttttg tatttttatt tttattattt tttgtttgtt tgtttttttt gagacggagt 20280 ctcgctctgt ctcccaggct ggagtgcagt ggcccgatct cggctcactg caagctccgc 20340 ttcctgggtt cacgccattc tcctgcctca gcctcccgag tagctgggac tacaggcgcc 20400 tgctaccaca tccggctaat tttttgtatt tttattggag atggggtttc actgtgttaa 20460 cctggatggc ctcgatctcc tgaccttgtg agccacctgc ctcggcctcc caaagtgctg 20520 ggattacagg catgagccac tgcgcccagc tagttttttg tatttttagt ggggacaggg 20580 tttcagtatg ttggccaggc tggtctcgaa ctcctgacct catgatctgc ccacctcagc 20640 ctcccaaagt gctgggatta caggcatgaa ccactgtgcc cggccttctt ttttgctttt 20700 tttggagatg gagtctctgt cacccaggct ggagtgcagt gtcaccatca tagctcgctg 20760 cagccttgaa ctcctgggca atccttctgc ctcagcctcc caaggagcta cagatttccc 20820 cttttaaaag cacacaagcc atgtggatta gggcccaccc taatgacctc attttaactc 20880 gatgacctct gtacacaacc ctgtgtccaa ataggatcat atcctggggt actggtggtt 20940 ggcactgggg agacacagtt caccccatga catagtgcat gatctcatga catctctttg 21000 tgaaacctct cagtggctta ttggcccatt ttatagatga ggaaagctga ggcccaggcc 21060 aatcaagaat atacagcatg ccatcatttc ttggttcatt ctacaagcaa ttactgagtg 21120 cctgctgtgt gccaagcccc tgtgttgggc actaggggcc cagtgtgagc agacatacct 21180 ggtgtccttc ccaaagggct cacaacagac aggcacaggg ccagggggtt agggcagcaa 21240 ggatgcgagc tttggtggtg caagtccagg tgctgctggg gcccagagga ggtgcctggc 21300 tcagcctagg gaggtgggag tggggagggt gacccccatg cccagggcat catagctgag 21360 aagtaacgtt acagagcagg gaaaggaagg gtatttcaag cagggatcca gcatgtgcaa 21420 aggccctgag gtaggaatgg gggttctttg ggttggcagg ggcatagagg tggggctggg 21480 gggtagagtg aagctggagc atggggcgtg gccagggctt agaggcaggg ttgggggcgg 21540 agtgaagctg gagcccaggg cgtggccacg gctgagagtc ggggctggga gcagggtgaa 21600 gctggggcct ggggtgtgac caggacttag aagcggggct gggggtcgga gcgaagctgt 21660 tgcatggcca gggtttaaag gtggggctgg gggggtgcag ggtgaagttg gagcctgggg 21720 catggccagg gcttagaggc aaggctgggg gaggctgtgg ggtgaagctg gggcctgggg 21780 cgtggccagg gctgagtggt gcggctgggg ggcaggttga agctgtagcc tggggtgtgg 21840 ccagggctta gaggcggggc taagggcagg gtgaggctgg gacctggggc gagtccaggg 21900 Página 16 ttgagtagcg gggccttggg cgcggtgaag ctggggcctg gggtgtggcc agggctgaga 21960 ggcaggactg ggggcggggt gaagctgggg cctggggtgt ggccagggct ttgggctgct 22020 gtgcagggtt caaatgacat gggaggggct cctagagggc agcgctgatg tgggcggagc 22080 caggtcgact ttgtgggccg agccagtctg actgggagcc atggagtggg tggggaaagc 22140 gtgttggaga gaggctggag gctccttacc ccagcgactc ctcaacgtct gtgccccaca 22200 gtgaagcacc cgcccgcaga gccctcccgc ttcatctcgg ctcccaccaa gacaccggac 22260 aagatgggct tcgacgaggt gagctgggcc ttccctggag gcggggcggg ggctggaggg 22320 cccttgtttg caggggctga tctggctggg gactctccgg gctgcaggtc ttcatgatca 22380 acctgaggcg gcggcaggac cggcgggagc gcatgctgcg ggcgctgcag gcacaggaga 22440 tcgagtgccg gctggtggag gccgtggacg gcaagtgagt ccgaggcctg ggggtggggg 22500 ggcgggtccg cacgtggatg tgggtgtaga cctcgctggt agacggcaag tgattcagat 22560 gggggcgggc gtggtgtcca aacagatgta gacctcgtca gtgggcgtcc tgaaggggaa 22620 gtgaatggga ccctggggaa ggggcagatc ctcacagttg tagaccatgg aaggcaagtg 22680 agtcctgacc caggggaatg ggtaggtttg catgctgcca gtgtagactg gtggggactg 22740 tggaggggta agtcagtcag accccaggag aggaggagag caggtttgcc cgcgagtgta 22800 taccatgtgc aggtgagtga ggccccatgt gcccggaagg ggtgccagtg ctacaagagg 22860 tggaccagct gctcaacgcc gcagggggtg gtggaatggc cggggatggc agaatggcag 22920 gcagggtgaa ccttcttcgt gaccctctcc tcctcctctc cagagccatg aacaccagcc 22980 aggtggaggc gctggggatc cagatgctgc ctggctaccg ggacccctac cacggccggc 23040 ccctcaccaa gggtgagctg ggctgcttcc tgagccacta caacatctgg aaggaggtgt 23100 gtcctgagtg atgggcgggg ccagagttat gactctagat ctcatcggag atttggacgg 23160 gaaaggggtt gaaagagttc cccaaagccc cggctaggca tccagcctca gccatgggac 23220 ccatggcctc tctttagtga atgatgcgcc acaccagctg tatcaccccc aggtgtacct 23280 gccatccttc cattgcgcaa atgtggaaac tgagcctggg ggtaggggtg agcccttttg 23340 agcagcaggt ggtgtctggg gcctgggacc tgtaaacaaa tcctcattac tcccagcctg 23400 gtctctgtgc ttgatgttta gtactagaag tcatggccac agagccactt taaaccagca 23460 cctgcccagt gctgctgggg gcactcacca gcccaggcat cctcatccac cctcagaggg 23520 agaggctgtg attggaggag ggtgtctgac taggcttcga acttgggcca tcagggccgg 23580 gcatggtggc gcacacctgt ggtcccaact atttgggagg ctaaagtggg agagtggctt 23640 gagcccagga gttaaggctg cagtcagcca agatcgtgcc actgcactgc agactggaca 23700 gcagagcaaa accgtgtctc agaaaaaaga aaaatggctg ggcgtggtgg ctcatgcctg 23760 taatctcagc actttgggag gccgaggcag gcggatcacc ttaggtcagg agttcaagac 23820 cagcctggcc aacatggtga aacctagact ctactaaaaa tacaaaaatt atctgggtgt 23880 ggtggtgggc acctgtaatc cctctacttg ggagactgag gcaggagaat cacttgaacc 23940 caggaggcag aggttgcagt gggctgaaat catgccattg cactccagcc tgggcgacaa 24000 Página 17 gagtgacact ccatctcaaa aaaagaaaaa taaaatccgg gcgtagtggc acatgcctgt 24060 aatcccagct gctcaggagg ctgaggcaga attacttgaa cctgggaggc ggaggttgca 24120 gttgagatcg ttccactgca ctccagcctg ggcgacaggg cgagactccg tctcaaaaaa 24180 aaaaaaaaag aaaaagaaaa gaaaaacttg ttatcgaatg tgaagccaaa tgggggtgtg 24240 cggctgcaag gcgggaggtg catgaggcgt gggcatttga ggggctggga ggcctttctc 24300 ttctgagatc cattatggac ggcagagggc agaggtttgg atgtccagat gtccctggag 24360 ctaggagagg cagggagatg cactggcttc tctacgggtc tttcaaacct tctcaaagca 24420 aagctctgtg ctttagggtc aggcctggcc ttggcctccc tgtgatgtgg cggggcttcc 24480 tccctcaggt ggtggaccgg gggctgcaga aatcgcttgt gtttgaggat gacctgcgtt 24540 ttgagatctt cttcaagaga cgtctgatga acctcatgcg ggatgtggag cgggagggcc 24600 tggactggga cctcatgtga gtgggggtct gaggatgggg tgaagctggg gcctggggca 24660 aggccaggac ttagaggtgg gggtgggggc agggtggagc tgggacctgg ggatgggtca 24720 tggcttagag gcggggcttg aaggtggggt ggaactggag cctaggtaca tggccagggc 24780 ttagaggtgg ggctgggagg cggagtggag ctgaatccta cgggcgtggc cacagcgctg 24840 cagctgagcc tagagcctgt atgtctgggt gtggtcaggg tggcaggcgt ggccaaccct 24900 tggaagcgta gcaggagggc tcacgtggtt cctgggcctg aaggcactgt cagggctgta 24960 gcctataggg aagggcgttg gaaggatcac ccagaactca agggacctgg ccggaagcct 25020 gcaggcttgg tcaaggctta gagacttgac tgaggcctgt ggaggtggat gtggctaaaa 25080 tttgaccggg cagcctgtgg gcgtggctga agagcatggg ggtgtggtca gagctggagg 25140 tgtggccgaa gagtgtgggg gcgtggccag ggcgcctggt cttagacaag cccctggatg 25200 ggagtgccac caacatgttt ccagcactgg agccgtcctt ctcttctgta agtgggctgg 25260 tttgtcctct cccttcctcc atctcttttt tcccttccat gtgcagtgcc ctaatctgca 25320 ttctgggaac actgccccat gtgaatagta actgcacccc tccattcctg actgcccccc 25380 catcagggca cctcgcccac ctccaccccc actgtcctct gaactcagag cagcttcagc 25440 ctcagagaac gtctgcgtga tcctgctctc cccagctcca gatcctccat ggctccctca 25500 cgccctttgg aaaaactcac tcttctcccc catgaccgcc agacccctgg gctcctgcat 25560 tcactccatc cagtcacaga gctctgcaaa catgctgagc ctgctcccat cccaggacct 25620 gacggggtaa ctagatccct ggctttctgg gcaagctccc tccggagggc gggaggagag 25680 tgacaggccc gatcttgcac cccagctatg tgggccggaa gcggatgcag gtggagcacc 25740 ccgagaaggc tgtgcctcgc gtgaggaacc tggtggaggc cgactattcc tactggaccc 25800 tggcctacgt gatctccctg caaggcgccc gcaaactgct ggctgctgag ccgctctcca 25860 agatgctgcc tgtggacgag ttcctgcccg tcatgttcga caaacaccca gtgtgagagg 25920 ggcaggcggc tgctgggctg gggtttcacg gtgggtctgt cctgggagaa tggggatgtg 25980 agactcacgg cctccgagaa gatgtctctt cttttgccta cttctccctc cgtttgcccc 26040 ctcgcagatc tgtctccatt tgtatcccct gcacacttac gttttaatct gtccccgctg 26100 Página 18 acttcttcac ccccaatttt tcctccagct gtcccgtccc ctgaagccat tgctgcccct 26160 cactcccctc ctcctccccc caggtccgag tacaaggccc acttctccct ccgcaacctg 26220 catgccttct ctgtggagcc gctgctcatc taccccacac actacacagg agacgatggc 26280 tatgtgagtg acaccgagac ctcagtcgta tggaacaatg agcacgtcaa gaccgactgg 26340 gaccgcgcca agtcccagaa gatgcgggag cagcaggcac tgagccgtga ggccaagaac 26400 tcggacgtgc tccagtcccc actggacagt gctgcccggg atgaactctg aggggtagca 26460 gccagaaagc caaagcagcc atcggtggcc caggctccac gtgcttactg aggacatcag 26520 gtccacctct ggaccccttg gcaggccaca gagggctctc gtgtggggtg gtgtccagcc 26580 agctcttgct aagcaatcac gtgcacacag gcagcattaa tggagtgcct actgcatgcc 26640 agcaacaggg cttggccctg gggaattggg aggaaccaag ccctcttcat ctgttcatgt 26700 gcccagcatt tattaagcac ctgctgtatg caaggttccc atgttacggc agtgaatgag 26760 gcataattgt tccctccatc agcgattgat tcagtcatca agcagttact gatcagatta 26820 agaatcaggc actagtgata cacattcatt tttaaaattc attcaaggat ttattgagtg 26880 cctactgtgt gttgggtgcc attccaggct ctgggatttt tttttttttt tttttaagag 26940 tagagtctgt ctctgtcacc caggctggag tgcagtggtg tgacggctca ctgcagcctg 27000 cgcctcccag cgtccagcaa ttcttgtttc tcggcctccc aagtagctgg gactataggt 27060 gcgtgccatc acatctggct agtttttgta tttttagtag agacggggtt tcaccatgtt 27120 ggccaggctg gtctcgaact cctgacctca agtgatctgc ccgccttggc cacccaaagt 27180 gctagggtta caggcatgag ccactgtgcc cagcccaggc tctgggaata ttgagataaa 27240 taagatgctt ctatccattt attcaagcac atattggtca cctactgtgt gcctggcact 27300 catgtcacaa agataagttc ctgattcggt acacttactg agcacctgct gtgtgcaggg 27360 agctgagcta tgggatggga atgggagtaa acaaggtact ttttactttt ttcttttttt 27420 cctcactgct agacggtgtg ggaacttctc actcattggc ttctttccca cacacctgaa 27480 gagcactgac tgtgtgccgg gcactagtga tacaaaagag tgtgacagtt gttcagtctg 27540 cattttcgat catgggctac atgccgagtg ctggggcaca gagatgaaca agatcggttc 27600 cttcacttct tcatgccaca agtgtttatt gagcacctgt gtgccaggcc tcacagactc 27660 ccagttgggt tgaagaatgg ttgactgagt ttgattcttc ctgtaccctc ggtcgtctga 27720 gctgtgtgca gacaacatcc ccccaccacc caagagggag ggtagctctt ccgccaccag 27780 gggcaagcac aggtcctggt ggccccacgc cacatgttag cccccctgga gggggcgcca 27840 gttggagacg ggggctgggt gtccctggcc cactcccggt cccctgtgct ttacctcctt 27900 gcccttgtgt ctcaggtgtg gtccctgcct gcttgatgaa gttgctctgt tcaagccttt 27960 ggtgggatca tgtgtttggg ggcttttagg ggacccagct gcactggggc actgcccgtg 28020 gcctgggtag gacatttccc agcaagggct ggaggagttg ccgtgccttc agcctgaatc 28080 gaatgtcaga accagccagc ggtgcttcac cctcttgggg ataacttgct tagtttttta 28140 ataaatgttc ctggttggtt ttcacagcag tttgtgggat tttgctcggc accaaaacac 28200 Página 19 tgcccacgtt ccccacccct ggatggccga caagatttgg gaggaaacca gggcaggtgc 28260 agtagggaag ctgcccagtg gggcctggca tggtggctca tgcctgtaat cccggtgctt 28320 tgggaggcta aggtgggcgg atcacttgag gtcaggaatt caagaccagc ctggccaaca 28380 tggtgaaacc ccctctctat taaaagtaca aaaattagcc tagtgtagtg gggcggggtg 28440 gcgggggggg ggtacctgta atcctcgcta cttgggaggc tgaggcagga gaatcgcttg 28500 aacctgggag gtggaggttg cagtgaccca agattgagcc actgccctcc agcctgggcg 28560 gcagagcaag acacaatcaa accaaaaaaa aaaaaaaaaa gctggccagt ggagctactg 28620 tggggtgagg gtgtggtaag agccctgtgt cccctcatgc cataaaactt cccccaaaca 28680 ggcgggggac cgacagctct gtcttgagtc aacttcagga tccttccaca tgacttcgaa 28740 taaagagggg ctgtcgtgct ttgagtccc 28769 <210> 3 <211> 2241 <212> DNA <213> Homo sapiens <400> 3 tagaagtagc agaaaaatac taagcttcat ggggacagaa agtttattct ccaagtccct 60 ctttcccctt agctttgcct ggatgtatta cttgatgttg aattagtcaa agttgaaggc 120 actttttagg gtcttcagca gaaagcagaa tcctagaata tcctacaaat acaagacaac 180 ttgagaacta taaaagaaag aaaaggcctt gttcccatag cccacaagag ggctgagctc 240 agcgatacac tctgtgtggc tcaggagctt ctggcagagc acagagccat cagagagggg 300 gcccagagag cagagagagg ctctgctgac atggccagcc cagcgcctca tcccatccat 360 aaccctgctg ccctgcaatg actctcttcc cagcaataaa atctgggtca caggagttgg 420 agctctagcc atcacttgtc tctaataaat aactcccatt gattttccag ctcagggctc 480 accactcctt caccgtaagc gccaggaggc agacctggaa aatcactcac atattattgg 540 tgctcttcct cccccatcct cacccaaggt gcatataaac cctgaataac ctgaagtcta 600 agggcatgaa tatcagacgc tagggggaca gccactgtgt tgtctgctac cctcatcctg 660 gtcactgctt ctgctataac agccctaggc caggaatatg aacaagccgc tgctttggat 720 ctctgtcctc accagcctcc tggaagcctt tgctcacaca ggtaaggagg tgaaggaatg 780 gtcaagaatc ataaagtgag aaaataggtt gaagctgaga tatcttttcc ctgcatttat 840 actgaaggtc attatctttc tttctttatc ccgcagacct cagtgggaag gtgtttgtat 900 ttcctagaga atctgttact gatcatgtaa acttgatcac accgctggag aagcctctac 960 agaactttac cttgtgtttt cgagcctata gtgatctctc tcgtgcctac agcctcttct 1020 cctacaatac ccaaggcagg gataatgagc tactagttta taaagaaaga gttggagagt 1080 atagtctata cattggaaga cacaaagtta catccaaagt tatcgaaaag ttcccggctc 1140 cagtgcacat ctgtgtgagc tgggagtcct catcaggtat tgctgaattt tggatcaatg 1200 ggacaccttt ggtgaaaaag ggtctgcgac agggttactt tgtagaagct cagcccaaga 1260 Página 20

P201430887 ES 2 553 786 A1 09-06-2014 ttgtcctggg gcaggaacag gattcctatg ggggcaagtt tgataggagc cagtcctttg 1320   tgggagagat tggggatttg tacatgtggg actctgtgct gcccccagaa aatatcctgt 1380 ctgcctatca gggtacccct ctccctgcca atatcctgga ctggcaggct ctgaactatg 1440 aaatcagagg atatgtcatc atcaaaccct tggtgtgggt ctgaggtctt gactcaacga 1500 gagcacttga aaatgaaatg actgtctaag agatctggtc aaagcaactg gatactagat 1560 cttacatctg cagctctttc ttctttgaat ttcctatctg tatgtctgcc taattaaaaa 1620 aatatatatt gtattatgct acctgcattt gtttagtgct tgtcatagtc ccatatcttt 1680 atcttatgtc tactacttat ctatctacta attggtgttt cattggtaat tggtgtttca 1740 ttatcctgaa aactccaatt gccaagtacg gggaggaaaa cctgtaagta actagaaaga 1800 tatatcacaa agccagagca ctcaatgagc acaacagtgg caatacttaa aagctactaa 1860 caatcatttt aatgacgatt caaaatatgt gtggaattgt aatcacaatt ctcctatttg 1920 tttttccagc tacaaatcga tcaaaaaggg gtctgaggtt gcatcaggta gacaactata 1980 atgatataag taagcaatag ttgagaacct gacagcaagt aataagacag gaagaataaa 2040 actagaagaa gtcagaatga aaaccaaaaa agtatgagac tgggatcatt ttgtatgaag 2100 acaaacataa ctttatgtct caaaaacctc agtaggactg tacaatgctt gattttcata 2160 atgttctctt gatgtcatca aaaaatatta tactctgaat attgctcaca tgaatatgct 2220 gtctaaaatt cttccatgga t 2241 <210> 4 <211> 10638 <212> DNA <213> Homo sapiens <400> 4 cctggaaaga cctggttttc aaataactgg cttcgtctgt gtaaaacgag tcttgttgta 60 tgcattaaaa attatcttgg ctgggcgtgg tggctcacgc ctttaatccc agcattttgg 120 gaggctcgtt ctgttgccag ggaggctgca aaaggaggat gcggctattt ctgcttccat 180 catggaaggc tgggattcca caggcacaga aaggaaggag ggagagatgg gaatgtgact 240 gtcctccaga cacagcctct ggcaggatcg gatgtgggag agtgagggtc ccaccccagc 300 tggggtctac ccaggtccat gtcttggaca tgttgagagt ttttctggaa ggcagggata 360 cagtgtggtc caaaaacaca caaatgcccc tactggccca ggggttgtca caatagactg 420 gaagggtgac acatcccagg cgcttgccac ccatcacacg cacctcctac ccactggcat 480 ccttccaccc caggcacaca caaagcctca gtccagagat caactctgga ctcagctctg 540 aatttgcata tcctgtgtgt agattcattc ttcataacct ctgcccagcc tagcttgtgt 600 atcatttttt tttctctatt aggggaggag cccgtcctgg cactcccatt ggcctgtaga 660 ttcacctccc ctgggcaggg ccccaggacc caggataata tctgtgcctc ctgcccagaa 720 ccctccaagc agacacaatg gtaagaatgg tgcctgtcct gctgtctctg ctgctgcttc 780 tgggtcctgc tgtcccccag gagaaccaag atggtgagtg gggaaagcaa gggatgggtg 840 ctggagagga ctggaaggag gtgaggaaca ggacatgtgg ctgggagaca ggctggatgc 900 Página 21 agctgggata ccctggcata cggcaggaat gggtgcccaa ggctgtcaac tccctcagct 960 cacacacttc caggagcatt cagggagcct ctgcgctggc ccgaaataag accttcagga 1020 atctgaatct aaaaccccta gtttacagtg aaaacaaaga ctccaaagac caagcgacct 1080 gcttggggta gacagtcagg acggagtagg aaccatatgc ctggagctgc ttctgctcct 1140 gttccttccc tccttccgat ggctgggtac acctgcctga cgctgaggga aagagagagc 1200 agccccaagg ggaaagtggg aaggcaggtt ggctggaggg atggtgctag aaggaaaccc 1260 gtgcccaaat cccacactca gacaccactg cagtgggtct ggaaggcgag tggctggaag 1320 agaagagagt gggagctccg ggagatcaag agtcactcct aggataaggg aaggaggctg 1380 tttgtggcat gagaatgtgc aggataaaga catggaagcg aatggcttct cagttgtgtg 1440 agtttaaaat tcatgacatt tacaaattgt cagaaaaggt gttatatgtt tgttatataa 1500 caatcacttt ggaatgttaa tctgattctg tgccaaaatc tgaattactc agggttctcc 1560 agagaaacag aactaatagg tggtacacat atacatatat atgtacgtac acatacatac 1620 atacactgta tacacatgga tacacacaca cataggaaga gatttacata tatgtataca 1680 aaagagagag agagtagaga tttattttaa gaaattgact cacactattg ggaggagtaa 1740 caagtcctaa atcttcagag ccggccagca ggctggagac ccagggaaga gttgatgtct 1800 tagtcttgat tccaagggca gactgtaggc agaattcttt cctctttagg ggacatctga 1860 ggctttttct cttaaggcct tcaactgatt ggatgaagcc caccactatg gagagtaatc 1920 cactttactc aaggtctact gatttttttg taaattaaaa aaaaaactgt gggtgcatag 1980 tatgtgtata tatttatggg gtacatgaga ggttttgatt caggcatgca atgtgaaata 2040 atcacatcat caaaaatgag gtatccatcc cttcaagctt ttatcgtttg tgttacagac 2100 aatccaatta tacttttttg gttattttag tttttaaaag tatttgatta tttatttatt 2160 tatttatttt tgagacagag tctcactctg tcacccaggc aggagtgcag tggcatgatc 2220 tcggctcact gcaacctccg cctcccaggt tcaagcaatt ttcctgcctc agtctcctga 2280 gtagctagga ctacaggcac ctgccaccac acctggctaa tttttttgta tttttagtag 2340 agacgggttt catcatgttg gccaggctag tcttgatatc ctgacctcgt gatctgcccg 2400 ccttggtctc ccaaagtgcc gggattacag gtgtcagcaa ctgcgcctgg cctctctttt 2460 ggttatttaa aagtgtacaa ttaaattatg attattatta ttatttttga gatggattct 2520 tgttctgtca cccaggctgg agtgcagtgg cgtgatcttg gcttactgca aacctccgcc 2580 tgttgggttc aagcaattat cttgcctcgg gtgtacactg ccacacacgg ctaacttatg 2640 tatttttaat agagataggg tttcaccatg ttggctagac tggtcttgac ctcttgacct 2700 caagtgatcc actcacttca gcctcccaga gtgctggaat tacaggcacg agccaccaca 2760 cctggcccca gttaaattat tattgactat agtcaccctg ttgtgctatc aaatagtagg 2820 tcttattcat tcttcttttt tttttttttt ttgtgacaga gttgcccagg ctggaatgca 2880 gtggtgcaat cttggctcac tgcaacctct gcctcccggg cttaagcgat tctcctgcct 2940 cagccttctg agtcgctggg actacaggtg tgtgccacca cgcccggcta atttatgtat 3000 Página 22 ttttagtaga gatggggttt caccatgttg gccaggctgg tttcgaactc ctgacctcaa 3060 gtgacccacc tgcctcagct tcccaaagtg ttggaattac aggcatgagc caccacacct 3120 ggccccagtt aaattattat tcactggagt cactttgttg tgctatcaaa tagttttcta 3180 actatttttt ttgtacccat taaccaccct cccaatttcc ccccaaccct gccactaccc 3240 ttcccagcct ttggtaacca tccttctact ctctatgtcc atgaattcaa ttgtagggtc 3300 tactgattta aaggctaatc acatttagac actcaggagc aagaataatt ttagtaattg 3360 aactaggatt ctgccatatg acctccaaca tcattagcac ctgtgtaaat tgtatcataa 3420 aataattatg gaactattat ggaaatgtcc ctctctccca gatcccacct tgtaccaaaa 3480 tgcaaggtac aaccccggga attctgagct ccatcctagt cttaccctgt gctaattcag 3540 tctgggtcat ttcttgaatt ttctggtaaa ttctcctttc taccctttct aactatatgt 3600 atttgtcagg ttaagctaga agtgttaatt tttttttttt tgagatggag ccttgctttg 3660 tcacctaggc tgaagtgcag tggcatgatc tcagctcact gcaagctccg cctcccgggt 3720 tcatgccatt ctcctgcctc agcctcctga gtagctggga ctacaggcac ccgccaccat 3780 gcttggctaa ttttttgaat tcttagtaga gacggggttt caccatgtta gccaggatgg 3840 tctcgatctc ctgacctcgt gatccacccg cctcggcccc ctaaagtgct gggattacag 3900 gcgtgagcca ctgagcccgg acgaaatgtt aatttgtttt ttttgagacg gagtctcact 3960 ctgtcatcca agctggagtg cagtggcatg atcttggctt gttgcaacct ctgcctctct 4020 ggttcaagtg attttcctgc ctcagcctcc agcatgactg ggattacagg cccgcaccac 4080 catgcccagc taatttttgt attttttaat agagatgggg tttcaccatg ttggccaggc 4140 tggtcttcaa ctcctgatct caagtaatct gcctgccttg gcctcccaaa gtcctgggat 4200 tacaggcatg agccacggag cccagcctag aaatgttaat ttctaacgca tgtcagattc 4260 catgcacact gggcaaggtt ccattcctcc atggggtgac tcagggatcc aggccaattg 4320 catattgaga ctctttcata ttatcctgtg gccttcaaag tcgtcacctc tagggatgag 4380 aaacaaaagg gacaagccag ctggtagggt cttggacaag aagaaagaca tcacttctgc 4440 tcacattctc ttttgacaaa actcagtcac atggtcccaa tatatcttcg aggtggctga 4500 gtaatgttat cttcctatgt gtcaagcaga ggaaataatg tagtgaagac acaggatggt 4560 ctctgaaata tcatctcagg catgaaagta gagcatattc acttgagtga gcctccagtg 4620 gtgtgaagtt gatggcagga gaaagagctg gggaagaaaa ggccagtggc aggtctcccc 4680 tcctagccct atgcagcccc acagtgggac ccttgcatgg acctcaacca tcagaatctt 4740 ttcttttgca ggtcgttact ctctgaccta tatctacact gggctgtcca agcatgttga 4800 agacgtcccc gcgtttcagg cccttggctc actcaatgac ctccagttct ttagatacaa 4860 cagtaaagac aggaagtctc agcccatggg actctggaga caggtggaag gaatggagga 4920 ttggaagcag gacagccaac ttcagaaggc cagggaggac atctttatgg agaccctgaa 4980 agacatcgtg gagtattaca acgacagtaa cggtcagtga ataacagacc acaggggtgg 5040 aaggtctaac ccaagaggca gcccccccag tgtgagtggc aagggatcag caggatggaa 5100 Página 23 atagtcccaa tcccagggga agaacaggag acacagcaga aacacagaca tgtccacatc 5160 ccacccaccc cacagcacag gtgctccccg cttccccatc aattgcccca tcctcatccc 5220 aggcctcagg tcacacagga agtgatggca gagtcacttc ctatccaggc acctatgacc 5280 tctcacctcc acaccccacc catcggaggc tgataccccc gtgagaaggc atcagactca 5340 cccctgtcca gggaggttgc ctggagagtg agccactctc aaagtcactc agacctgggc 5400 tcacctggtg gttctgccag tcctagctgt tgacagtgaa acgttcccaa aatatctggt 5460 tgaaatctgc aaacattgga gcactgagac ctacctccaa acaagtctgt aatatttaac 5520 tatgtctgtt ctatgaagga tgtcacagtc tgtcctgatc tcccttgcag ctccatcacc 5580 tagcacaggg tacagccaat attggctcaa ttgaaatttg tggaatcaac agagaaaagc 5640 acccagcaca caccgtagcc catgctgggg gctcaggaag tgctggattc aaaactgtgg 5700 gctgttagag ttccttggag ccctaaagtt cctccttacc atacgatgca gacccaggaa 5760 gggccacctg cgctatggtc agaggagctg gtggcagagc ccgtgcagag atggtccctg 5820 tgcccccggc ccagtgctct ttctcctaaa ccacactgcc agccccaagg cagccaacct 5880 caggtctggt gaactgctgg tgttaaatta tcatagagtg ggtgtcaaaa gatgggctac 5940 taagtacaaa aatgcccaag gtgctacatg ggatctgaag attttcaaaa ggaggcaaga 6000 aagagatagg cagatgtttc aaggatgtgg ggtgggggag gtcttggtaa ggaaaatggc 6060 ccaggctgtg tgtcagcaat aggagaggag ggggcacagg tgatcagaaa agacactggg 6120 ggaagcattg atggacagga atagaaatgg caaagtggat aattaagagg aaggaggatg 6180 aggagatgaa cacagggtat tagaaaataa tagaaggcag ggcttggtgg ctcactcttg 6240 taatcccagc actttgggag gctgaggcag gcagatcacc taaggtcagg agttcgagac 6300 cagcccggcc aacatggtga aaccctgtct ctactaataa tacaaaaata gcctggcatg 6360 gtggcacacg tctgtggtcc cagctactca ggaggctgag gcaggagaat tgcttgaacc 6420 caggaggcag aggttacagt gagccaaaat cctaccattg cactacagcc tgggtgacaa 6480 gagtgaaacg ttgtctaaaa acaaaaaaca aaaaacaaaa aaaggaaata atagtagctg 6540 acatttactg agcacttact ttgtgccagg cccatctatg agcatatata atgctcagaa 6600 tagcccccta aaacagtgct cttggcattg ccatttcaga ggtgaggaaa tagaggcaca 6660 gggagttgag tggctccagt tcaggcaaca caccaggtgg gggtgggggg ctggggagag 6720 acctgggacg tgagcccaga cagcttgaga gctttcagag tctatgccaa cagcaccaac 6780 cagtgctggg taaacacctg cttttatcat cagaacaaag aggctgtgtc ccctgcccta 6840 tgaggtccat ttctgagagt tgtggctaat gggcaagaag gttggggctt tagagatttg 6900 ggataaagat atcaaacacc agaaaggtag aaagaagtga tcagattagg gttacttagg 6960 tgatgatatg aactcttcct agaactgaga gaaaaagaga gccttccttt actcatatga 7020 aatcacaaat aatttctatc caatttggaa gtacactttg gtgtagttgt gacagcttcc 7080 tcaggactca gcataaattc aaacaaataa ttgtccttag aagagatgct atagaagaga 7140 tagaaatata ttcatattct gtagcttttt tttttttgag atggagtttt gctcttgtca 7200 Página 24 cccaagctgg agtgcagtga tgcaatctca gctcactgca aactttgcct cctgggttca 7260 agggattctc ctgcctcagc ctcccgataa ctgggactac aggctacagg catgtgtcac 7320 tactcctggt taattttttt ttttttttta agactgagtc ttgctctgtc tttcaggctg 7380 atgtacaatg gctccatctc ggctcactac aacttctgtc ccccaggttc aagcgattct 7440 cctgcctcag cctcatgagt agctgggatt acaggcatgt gccagcacac ccagcaaatt 7500 tttgtatttt tagtagagat gaggtcttac catgttggcc aggctggtct caaactcctg 7560 acctcaggtg atcctttggc ctcagcctcc ctaactgctg ggattacagg catgagccac 7620 tgcgtccagc ctaattttat atttttggta gagatggggt ttcaccatat tggccaggct 7680 ggtctcgaac tcatgaccta aggtgatcca tcctcctcag cctctcaaag tgctgggatt 7740 acaagtgtga gccactgggc ctggtgcttt tttttttttt tttttttttt tttttgagat 7800 agggtctcac tctgtcaccc aggctgaaat gcagtagtgt gattttggct cattgcagcc 7860 ttgacttccc aggctgaagt gatcctccca cctcagcctc ctgagtagct ggggctacag 7920 gcatgcacca ccatgctgcg ctaattttta tattttttgt agtggtggga tttcgccata 7980 tcaccctggc tggtctggaa cccctgggct caagcgatcc actcgcttca gcttctcaaa 8040 gtgctgggat tacaggcatg agccacagcg cccaggctgt agctctctta aggaggaaca 8100 tatctcatct gagacaaacc tgaaatgcca aaccaaactg agttagcccc tctctgtctg 8160 ttgtatatat tggagtaata acctatttgt cttgataaag ggattgcatg cttgaattgc 8220 aaaaaccttt atttcttttg ggttgcccaa tgtgcaagac taagagttat tttgataaat 8280 ttctcaccag gctgactgtc tctctgtggg gtcgggggag ttttcagggt ctcacgtatt 8340 gcagggaagg tttggttgtg agatcgagaa taacagaagc agcggagcat tctggaaata 8400 ttactatgat ggaaaggact acattgaatt caacaaagaa atcccagcct gggtcccctt 8460 cgacccagca gcccagataa ccaagcagaa gtgggaggca gaaccagtct acgtgcagcg 8520 ggccaaggct tacctggagg aggagtgccc tgcgactctg cggaaatacc tgaaatacag 8580 caaaaatatc ctggaccggc aaggtactca ctgcttcctg ctccccagta ctgagcccag 8640 aataaaagac gatctcaggc taggagctca ggcaacatct tagtccggtc tcatctgttc 8700 ctggatgtcc ctcagacccc cagctttcat cttttaggat ttattccttc cctgggataa 8760 tataatttgt ggtccaaaaa gaacatcatc aaaatttcag gcagaatggg ccaggaaggc 8820 cattctttct tgatgagtgt ccccaaatca tctccaatta acagacaagg agcttgaggt 8880 tagggaggtg agggtaacac tgtctgtaag aggcagagct gggactcaaa ttccagattt 8940 cagattccaa atcccatcgt tttttatctc tacaatgatg cctcccatct gggtggtgga 9000 gagaagggag gcgtgtaaaa tgtcagcccc agaaggacaa gagcaagcca gtgtgagcgg 9060 aattgatggc tgcaagctga gacttggatt ggagacgtag tgagactcag gattgtgcag 9120 tgctgcaggg aagtggttgc tggatagagg catgggctga accaagcagc tggactgaga 9180 ctgggggaca gaactccaaa gcccactgag atgtgggaaa acatggagaa gcacacggag 9240 cattcacaac ttattgccgt cagagtcaat acatgggtga ggtggggatt gggcaagagg 9300 Página 25 gaaagcgtca gccttccctg atattctgga aagtctcccg gggctggggg tgggcaggta 9360 cagagcttcg agctctgctg atcgctgaca tccaggggtg ggggtaggaa gagacctggg 9420 ccgggagaag tccacctcaa gcctgcagtg tcacactcta tccctccaca gatcctccct 9480 ctgtggtggt caccagccac caggccccag gagaaaagaa gaaactgaag tgcctggcct 9540 acgacttcta cccagggaaa attgatgtgc actggactcg ggccggcgag gtgcaggagc 9600 ctgagttacg gggagatgtt cttcacaatg gaaatggcac ttaccagtcc tgggtggtgg 9660 tggcagtgcc cccgcaggac acagccccct actcctgcca cgtgcagcac agcagcctgg 9720 cccagcccct cgtggtgccc tgggaggcca gctaggaagc aagggttgga ggcaatgtgg 9780 gatctcagac ccagtagctg cccttcctgc ctgatgtggg agctgaacca cagaaatcac 9840 agtcaatgga tccacaaggc ctgaggagca gtgtgggggg acagacagga ggtggatttg 9900 gagaccgaag actgggatgc ctgtcttgag tagacttgga cccaaaaaat catctcacct 9960 tgagcccacc cccaccccat tgtctaatct gtagaagcta ataaataatc atccctcctt 10020 gcctagcata acagagaatc ctttttttaa cggtgatgcg ctgtagaaat gtgactagat 10080 tttctcattg gttctgccct caagcactga attcatctga aactcttggt ttcccctgga 10140 ggccatggtt cctgggcacc ttgacctggg caatcccaag tgtggcctga accccctttc 10200 ccttggggat tgttcaggtg tccctagacg ccttgtggta ttgtacctaa tacccatgaa 10260 gggagaggat gatattactt gccagtgtac acccccctgt gatattgttc ataatgtcca 10320 gagtgaagaa agatgatatt actcccaata tcacagaagg tgtacacccc cccttgatat 10380 tgttcctaat acccagttgg ggaggggaga atatctctcc caatatacaa ggggtgttta 10440 aactctctgt gatattgttc ctaatattca ggggggacaa ggatgatatt acccaaatat 10500 tgcaggggtt gtacaccccc cctttgatat tgttcctaat atccaggggt ggagaggata 10560 ttactcccaa tattgcaggg gtctacatcc tccccccgtg acattgttct taataaccaa 10620 aaggtgagaa gctgacat 10638 <210> 5 <211> 27502 <212> DNA <213> Homo sapiens <400> 5 ctaaatgtca gtgaggccat agctaatatt ctcttgaaaa gggaaagttg tatgcatcct 60 aagagggtgt tacttggaca tgcatgtgtg tctgtgttat atcacatatg ttgagtccag 120 ggagcagttc atggagcctc atccatagtt tccctgacat gctatagcag tgctaaaagc 180 ttaaaaaaaa aaaaaagtct ggagaagtat gcataatgca atagctacag tcattagaag 240 aaaaaaaaag tatggttctt tctcaggtac atctgaagtt tgggtatata cttcagtaat 300 gttggtatcc tttattcaga ttgataaata ttttattagt ctatacaggt tgagtaattt 360 ttgaaattgt aatttacaaa tattcattca cttaagaatc taatattttt aaaactaggt 420 atttcttgaa tgactccgac tgcactttca atggccagtt gccatgcatt attaaacttt 480 Página 26

P201430887 ES 2 553 786 A1 09-06-2014 cttttttttt cttcttcaga atcttccagt agacgtctag agtttagcta gaagtcttgg 540   ctacgataca aacagtgatg gaaaacacat gagcagtaac aagttttaat cttgctcctc 600 agtactaaca tggactaatc tgtgggagca gtttattcca gtatcaccca gggtgcagcc 660 acaccaggac tgtgttgaag ggtgtttttt ttcttttaaa tgtaatacct cctcatcttt 720 tcttcttaca cagtgtctga gaacatttac attatagata agtagtacat ggtggataac 780 ttctactttt aggaggacta ctctcttctg acaggtatgt ttcatgtcta tcttacaagt 840 atcgatgtat actttacagt caatactaag gagacattaa tgttattaat aaatgcttat 900 aaataatagg ataaagtcca aagtttatct ctataatttc ttaaaaatca gcatttaaat 960 acaaacctaa atttgtacct aaaattattc tagttttatg tcttacctat aatgaatgta 1020 ttttaaatat aattatgtga cttttttttt cagctaagtg aaaacctgtc attatgcctt 1080 accataaatg ttaacatgat tgattttaaa agtcatctaa ataaacatct tgtatgttta 1140 tctaggaaaa taacattgct ataataatga tcatgaagtt tggggatatc acagctatat 1200 taaatgaaac agtaaatata tttttcaata tttaaaatat tttctaatgt gtatttaaaa 1260 tgtgtgaatt actgaaatgt caattttact tatacatttg aatattcatt tttttccttg 1320 ataaatgtct tccttattat aatgaaatgg cactgaaaag ttcaaatgga aatctattca 1380 attccaagaa agaatactta tcagcaatag tttagctagc actatattca atatgaaaga 1440 ttaggaaatt ttcacagcat gtatacagtc agaatttaac actttcaaag atttcctttg 1500 tctactccca aagtaaattt ctgattaaat tttagattaa aaaatttaag caatgtattc 1560 aatattctac tccctagtaa tctaaatagc gcacagcatt ctttcatgtt aatctattca 1620 gaggtgtggc acccaggaaa cagtggccac atggtgtagg gactgagtca taaagaacct 1680 gagggggttg tatttcccta aaaataaagt tgtttaaatc caagaatcaa gctgttaaaa 1740 gaaagaaatg aaaaaagaaa gaaaaatcga gcacaagccc acacacataa aaggatcctg 1800 atgtttttag tttgtttttt ggcattaagg agtatagtgt agtagtggaa agaacagagg 1860 atatatagtc ttctgttaca actaactact caattaaaaa caaatattct gataactgat 1920 ctgaggtttg agacaaaaac aattaacttt acaagcacaa gtcttgaggc actgtgggaa 1980 acatcataaa aatggagagg cagtagattt tgttttttaa gacagtagct tgattgctag 2040 acatgtggag aaattaatga agggcaaaat tagtataaaa ggaagaacag ctagaatgct 2100 ttgtcagaat gctagttata cttctaaggt aaaattaact actttttaag gaaagtgcta 2160 tctttatcag tatccatgaa caaatggtac tgtgaataag tttccaaatg catgttggac 2220 ttttaactca tttgttagct tacaagacta tgccttgatt acatctgaat ttggtttgga 2280 ttccttcggt gaaatatatg gagtatgtta tatcacattt atatgctgaa atctgctact 2340 ggtacctgtg aactgatagg catgtttaaa cccaggggaa aagttgccaa gcgggccttt 2400 aaacatggga tttaaaagca cagtgactta tttacctaat aatagtgtct gagaggaaat 2460 accatttcac ttagataaac tttctaagtt tgtagaccag ttaaatggaa acaagaaagc 2520 ttatgtgctt cttaagcttt atttccagtc catatgttat gaactctttt aagaacttgg 2580 Página 27

P201430887 ES 2 553 786 A1 09-06-2014 ccaaacctcc ttacctaggc ttttccagag gaaagtctgt ttactgtctg gaagtaacta 2640   tgagattaaa atccatttag gaggacatgc agtctagtgc aaagcacaac caacaagcag 2700 tgaggaagcc agccctcagc tccaccacct ccagccagtt ctggacgctc actgcctctg 2760 ctttttctca gtaaaagagg gccatggggg gaaagtctca aagacctctc ttagctctag 2820 gctactatga tttattagta atagcagtag cactggaaga atactccaaa cactactctg 2880 attaagagag acttgaaacc aaaatccaaa gctttccatg agtggaaaac actggcaaaa 2940 ctggtctaaa tcagggaaat attgagtatt cctgagaaga agatttaata tttttaaagg 3000 gtttaaaaat agagtaacct gaatactgcc aaaactaata aaacagaggt tgtacctcat 3060 taataaactc aaaataaaac agccaaaagt catatcattt taaatgacat ataatattct 3120 ctacattctt tctgaataat aagaaaaaaa tactgctatc tagggttctc tcctagacat 3180 tccattattt tcctattggt aaacagttgc acactgaact gggggaggtt taggacctat 3240 acttgattgt acttattaac aaagcagtgg aagagaccca gcaagagact caggtaaaga 3300 gtgtaaataa tgaattcctc atggtatcaa ggttggcctg acttttttct ttgcaagcaa 3360 ccaggataca caaatgcaaa agattagatt aattgtaaaa ggctaacaga agacagaact 3420 agcagagaga aatgaatttt ccagaaggca tttttgagtt tccatataaa gactttccta 3480 acagccatgg atggacaact gtggaagatg ctgccttgag gtagtatcct ctccctggag 3540 ctattcaagc agggtggata tgctccctgt tccagaatgt tctggaacct tcaccaccag 3600 gaggaactcc tgtttcaaag gtcttcatct cttattctcc aggaaagggc ctaactacta 3660 tataaaagtg gctgcctcca ctgctcagca actggaatgc ttcccaacag ctaaagataa 3720 tgctactgcc taaaacttgc aggcagaagt ctccatttca tattttaatt ttaccgcagt 3780 tttgattaaa ggcagggagg gtctcctgta acttatcagt ctcagaaaga ggagagacaa 3840 aggaaggggc cccggctgat gcttctcctg atgccactgg gggactggtc agcagccctg 3900 aggcagggat gtggaaaaaa gcaggaccac tactgttctg ctccctgcct tccctgccct 3960 gtgtgccttc tccttctcct ctcaactctc agttctgctc ctcatacctg atccagttcc 4020 tcatctcgaa cctcagctca gtactgggga agcctctctt gacggtggca cgaggctgaa 4080 ggcatctggg aaaccattac gtggtgtgca aaggagctga ggccagtcct tgctcccgct 4140 gccaggccac aaggaacacc acgatgtgtt cttggcaccc cactttggat ctctaacaca 4200 ttcctggtgt tttacttttt ttttttaagt tccatagttt ttttgtttct acattttgga 4260 tatattatct gttaaatagg tttttccggt ccagactggg aatctaaagc ccatttggtt 4320 caaagattct atgggaaaaa acttaaacta aaacattcag gctgggtgca gtggctcaca 4380 cagtggcaca ctttgggagg ccgagatggg tggatcgctt aaggtcagga gttcaagacc 4440 tgcctggcca acatggtgaa accccatctc tacaaaaata taaaaaatta gccaggcatg 4500 atggcacatg cctgtaatcc cagctacttg aaggctgagg tgggaggatc acttgaacct 4560 gggacgtgga ggttgcagtg agccaagatg gcgcaactgt actccagcct gggcgacaaa 4620 gtgagactcc atctcgaaca aacaaacaaa caaaaaaccc caaaaaaaca aacaaaaaag 4680 Página 28

P201430887 ES 2 553 786 A1 09-06-2014 cacaatcaac caacttaaaa aataaccttg tcaaaatctt catttcccat tgaccagaac 4740   aaataggatt aagcctcaag aaattgtgaa ccccaaaaca atttcccaag taggtgctat 4800 tgtttgactt ttgggtagaa atagatgaga atagtgtgta tgagaaacct ttgattacac 4860 caattcctac caaaagtggt aggaaaagac agcagtatat gcagaaataa agcaaagaaa 4920 attctgttgg cggactgaca tttaaaatat tttaaaagca acataattaa gaaactatgc 4980 atgggaagaa aaaaaaaatg ctttgcttat aatcccatta tccctcttac caggtttgta 5040 cattctattt caatcttttt ttcatgtgaa tatatgtttt tataaatgtc tttagttcta 5100 ttggtctcaa acagtaaact gagggttatg cgtagacaga cacggtgaag aattttactt 5160 tcaaagctct gggtaccaca catctagtgt taaagcccta cacccctgtt cctaccccat 5220 aagtcacagt atatacagtt tacattgtct atttactaat ccaggcattt tattttttag 5280 tttttctatt aatgtacctg acattcaagt gttaacttta cgatctcgta ttacctgaca 5340 gtagttgatt aggagttgcg ggttttttat ttttgagtag ggaagtgtgg gagagaagag 5400 gatggggagg aaggtgtgct ctactttaag aaattcagca ttctgacgag tgacactgca 5460 tggggtacag tgggtgcttg gtaaatgccc actgaataac tccagcaacc tcaaagaaag 5520 ccagaaacag gaccttaaat gacattataa ttctatagct ccttgttgcc aaggtcagac 5580 aaggtcaagg gcagctatgc acctagaaga cagagctgta atgcaagaat gttacagaat 5640 aaactggaat caggggccaa ctttgattta gctaaggacc aagagctgaa ttttctaggg 5700 aatgagtatt ttgaaggttg aggcaaagct gggcactaaa ccttaaggag tcaggagcca 5760 cacaacagcc ctaagtcaaa acacataatg agtcaaagtt agacagacag caaaggcaca 5820 gagacaatgt gccagggaca aagtgatatt gagaaggaag cccccagtaa cctttaccag 5880 gaccccatac agcattcaca ggatgactgg aatacgaaac atcaacctgc ctgccagcag 5940 ggacacccca tgcctgctac agaacagtag tcagccacag ttggtgattt ccacctgggg 6000 ctctccaaaa gaagccactg aaccctgtgt tgccagcaca atctctcacc cagtactaca 6060 caaatctgat cacacaatca ttctgttctc taccttccaa tccaagctac acaggtgctt 6120 ctttatgtac agatgtgtac agaacagtaa tttgtatact ggttagataa gaaaaaatga 6180 cagagtatgc ccatgaagcc acgagatttc tggataaaac aactgagtcc ccccacatga 6240 gctggagcag aaggcagcac agaacaggga gttgggacac atgagcccta gctctggctc 6300 catttatatt tggtaggtga ctttgggcaa gtcacttaag ctctttacgc ctcatttcct 6360 atgagggatg agtctagaat aacatctgaa ttaacacctc cacaaagtag tgtacagatg 6420 ggaggctagg gctagttttg aaattggaat cagcatagga ttattaaaat ataaaaaact 6480 cttgccattc tcagatctgt cctgtaacct ccttcctagc ataagttagt gtggattatc 6540 acaggaatat cacacatacc tgaccagtgc catccagcta cccagtgggc aaatgttcat 6600 gccaccattt agatttttgg agcatatgag aaattaaata aagtaattat caggttaata 6660 actaatgaca gtaggacatt ctagccctcg tctggtgatt aaaaaagaca taccatatat 6720 aaatgaagat atttattaag ttaatgaatt cattcttgat ttttaaatcc aggaaaaagc 6780 Página 29

P201430887 ES 2 553 786 A1 09-06-2014 aggcccatgg agagatgtta aagctgattt tttggttctg ggaaattgca accagttggg 6840   atttggaggg gtaggtcttc ccgaggctgg gccaatcctg gctgactata gaagtctttt 6900 gcagctcagc tgctctctgg cactcgggca atggcaggcc tggaggacta tttaggtgac 6960 tgtagcctgg tggactatta gggtctgcgg agccctctgc tgtggtggtg agtggatgcc 7020 ctcctgccag gactcagttt caccagtgag catctctagg atgcatctat tttgaataat 7080 ttcataatgt ttttaatttt tgaaattttc aaagaatata cacatttcac aggtaataat 7140 ttaaaaatta ggatatgtaa atatggcaat aaatctatgc tctgaaggtt ctcatttgta 7200 tagttctgtt ttgtgtgcat tttaaaaatg caactgaaaa caacctggcc ccccaaaaac 7260 aaaacaagca aaccgaactc agtggaaaga tgagtaagaa agaatagtct ggacatcaga 7320 cagtttggat caaatattag acaatggaac agattagaag gaaaaagata ccaattgtgg 7380 aaaaagtgac caactatgag agtgaggttg ggaaaggtgg agagaaatca gttaaggaaa 7440 aattccagat gttgtctaag gagacaatga agatattcct ccttcaggga cactgaatac 7500 attaaggcaa tagaaagatt ttgggaatac agagttaggt aagataatct gtttctgttt 7560 ttacgatgtt tattagcttt ttcattataa aggtaatact cattgctcat tatgaaagtt 7620 aaaggaaaaa ggaaaacaca agtcatctat ggttctagtg cccagagttt atcatcaatc 7680 aggtatattc ctgccaggtt tgtttttgtt tgtttatgag tgtttgtaag tatacagttt 7740 atggattttt tatatttgct tttttttatt tcacaaaaga taatatccca tatttaaaag 7800 tgtctttgca agcattttgt gggttccaaa atatttcatg gaataaatat actcttttat 7860 tttactattc ccctttaacc attatataat tgtctcaaat atttctgcta ttataattct 7920 gtgatgaaca tctttgtgca ctttagaaat gtttcctgag actagatttt aaaaagtaga 7980 attactatct gaaaaagaga tatttttaga gttcccaatg cacattgctg aattgctttc 8040 caaaaatctt tataaattta ctctcagatt agctaagcaa tggattaaaa tgccatttca 8100 ttgcactctt gccagaactg agaaatgtat atatgcagga attatatcca tttaaattta 8160 atatcccatg tctgtttagt cctagactgg tcttctacac taagacacca tgaaggagta 8220 tgtgctccta ttattcctgg ctttgtgctc tgccaaaccc ttctttagcc cttcacacat 8280 cgcactgaag aatatgatgc tgaaggatat ggaagacaca gatgatgatg atgatgatga 8340 tgatgatgat gatgatgatg atgaggacaa ctctcttttt ccaacaagag agccaagaag 8400 ccattttttt ccatttgatc tgtttccaat gtgtccattt ggatgtcagt gctattcacg 8460 agttgtacat tgctcagatt taggtaagaa tataagtcga ttttgttttg aagaatagta 8520 atgctattct gacaatttaa aggatggaaa aagtctcatt gaaatttcaa aaataatctg 8580 agtgtataag tttttttcat ttaagttttt aggtggaaag tacagcaaac cccaaagtac 8640 atccaaactt atttttaaaa ttaagaaaat caaaggaaaa ctaagggaat gttgtccata 8700 gaacatttcc ttctcttccc cagttaaatc aaagcattta attttaattc ccttcagaga 8760 gaatggacat cacatgcagt tctatctcag ggtgctagca ggttgagact gtacttttca 8820 gtaaaactcc atgataacaa aataagctgc atgtctagaa caatgaaatg agttatagaa 8880 Página 30

P201430887 ES 2 553 786 A1 09-06-2014 agcttgtgaa atctctaatc tagacctttt aaagataatg ctttatttgc tttttagcaa 8940   tttgggttta aaactgccta agaaaaaagt ggataaagtc tttttaaaat ttataattct 9000 ttgctgagta ttttatttct ttaatacttc taatgaagga gcactcaaga gcacagccat 9060 gtcccgttca aggacgggac ttaatgggaa tgcatatcaa gagttgttgc cttcagctat 9120 ttccaagagg ggacagctga gactggcccc actgtggagg ccaaggtctg gcacacaact 9180 cccactcagg ggctgatggc ccatcagggt cacttcatga gtctgtatga gcagatgtct 9240 tgaaaagcat tagacgtgct tcctactgcc atagcattca tggcaagagt taaagcttac 9300 aataatctac tctagagacc ttaatgaagt ttgtcattat atgacaaaat gagaggcaaa 9360 caaaaagcat tcagaaaaag gggagactaa tacgagctag acttactagt aaagtctaat 9420 gaaataggct aggaaaaaaa atgggtctta agctttacct gtggaattct catgagaaag 9480 agattaagat gcaagtactg tttgagaaaa cttgttcatg tagaacgact gtggaaacag 9540 catcaggaac aagaaatgca gaagctgaga cagatgctgg gtgtgagaag aggttagtta 9600 gggaatatga gaatgtacta ttgtactaaa ctgcatctca gacaagaaaa aacgttacct 9660 accatcagtt tgcaaagtgg gtgcatgtta aagcactttg taagtcaaaa ttccagataa 9720 aaatatgtgt atctgctatg actccaccag atgtaaactg ggttagttct gggtaagatg 9780 gtgaataagg acacatttat ctttagtgca gaccaccccc acgtgctggc ctccatatgt 9840 gccacggcag agcagtcata tgcttccaac atgaagaccc tgcatgagac attgcataaa 9900 actactccag aacacacttg tcaccaaaga cttgagaagc ccaagctacc tcatggcagg 9960 aagctggtgt tcccatcaca cacagtctcc caaacattta gctttgaaaa aactctagta 10020 aacaaaatcc acctaagaat atctgtgaca gtcagacatg ccatcagcat gctgctgcac 10080 ccatcctacc tcccccaaaa cgtgaccata aaaagggtct gggcacttat cactcttcct 10140 ccctcaggag atgaaactct tcagaacttc agttttaaca ggggcagggc aggagtaggt 10200 ttgtcaaaat ctgtgctacc aggaggatcc cttctgcaga acctccagct tcctataaga 10260 cttccacttc attttctaaa accaaaataa tatcctgtgt tcataaaaat ggcaaaatta 10320 atctattcta acaaacaaaa ctgcacccta ccttgctaat tcatcaagtt accccccttc 10380 ttcttcccat atagggttaa atttcttaag aaagtatcaa ttttatttta gtattattat 10440 tatttttttg agacagagtc ttgctctgtc acccaggctg gagtacaatg gcgcgatctc 10500 ggctcactgc aacttccgtc tcctgggttc aagcgatttt cctgcttcag cctcctgagt 10560 agctgggatt aaaggcgcac accaccatgc ctggctaatt tttatatttt tagtagagac 10620 gaggttttac catgttggcc aggatggtct tgatctcctg acctcatgat ccacccgact 10680 cggcctccga aagtgctggg attataggcg tgagccaccg cgcccagcct atttttttat 10740 ttttattttt gagacagagt ctcactctgt cacccaggct ggagtgcagt ggcactatct 10800 tggctcactg caacctctgc ctcctgggtt caagcgattc tcctgactca gcctcccgag 10860 tagctgggac tacaggcacg tgtaacaatg cccagctaat ttttgtattc ttagtagaga 10920 cggggtttct ttcaccatgt tggccaggct ggtcttacaa ctcctgacct taagtgaccc 10980 Página 31

P201430887 ES 2 553 786 A1 09-06-2014 acccacctcg gcctcccaaa gtgctgggat tacaggcgta aggcaccatg cctgaccaat 11040   tttaaagtat agaaaggaaa agtacataga gctgtaggat agaatgttga tattcaaata 11100 ctagattttc aattcttcaa tttttggcta ttaaatgtat gactacactt caggagtgag 11160 gacggttcta tcaaaagtgt actgacatct aggccaaggc aggcatctcg cttgagtcca 11220 ggagttcgag actagcctgg ccaacatggc gaaacgctgt gtctagtaaa aatacaacaa 11280 ttagccaggc atggtggtac acatcctagc tactcgggag gctaaggcag aagaatcact 11340 agaacccagg aggtggaggt tgcagtgagc cgagatggcg ccactgcact ccagccgggg 11400 cgacagagca agactgtctc aagttaaaaa aaaaaaaaaa aagaataata tatgaatcag 11460 tatgtggaaa tcaaagaatt tacaactaat tagagaagtt aattacttaa aggaaatggg 11520 tggtaaagtt tttggtaata tacatgaaaa aaatctaatt tttccatttt ctaaacacaa 11580 ctatctaagg cttcttaaaa tgatcaagac ccggctgggt gcggtggctc acgactgtaa 11640 taccagcact ttgggaggcc cagtcaggcg aatcacgagg tcaggagtct gagaccagcc 11700 tgaccaacat ggggaaacct cgtctctact aaaaatacaa aaattagcca ggcgtggtgg 11760 cacacacctg taatcccagc tactcaggag gctgaggcag gagaactgct ggaacccggg 11820 aggccgaggt tgcagtgagc caagatcatg ccactgcact ccagcctggg caacagagcg 11880 agactccatc tcaaaaaaaa aaaaaaagaa agaaaaatta tcaagaccca tatgctccaa 11940 tttagcacta taacagcctg aaaatttgca aagaaagcta acattcctca gccaaaggta 12000 catcaacaga agctgcacct cagtggttgg tcaccttctc acagccacta aggccactcc 12060 aatttatctc cttttattcc accttagagg ggatgagtag tgacaactat accaatctag 12120 acaccttgta aaaattaata agttactcaa aaaggtcctg aggtcttccc ccaaaacaat 12180 gttttttttg tcatctgtta tgactgttaa gtcatctgta acttgatgat aatcatgggt 12240 tttaaaaaat gtatatttct accatattag taatctcatc ttcagcatga ttctctatta 12300 tataatatgt ttgtttcttt ctaaggtttg acctcagtcc caaccaacat tccatttgat 12360 actcgaatgc ttgatcttca aaacaataaa attaaggaaa tcaaagaaaa tgattttaaa 12420 ggactcactt cactttatgt aagaatatat cctcatactt tcaaagattt aagtgaaaac 12480 tctgtatctt tgctataatg attaattata ctatgttagt ataaacaagt cttacttttc 12540 tgtaaagaat gacaaaaatc cctgcattca acagcgttct agtcaattaa aaattataga 12600 tttcattcaa ttaatagtct aattcaatgg atgtttatta aataatagcc atgtaaaatg 12660 tagtgggctg agtttaatgg tcctcaaata agcttacaat ctattcaggt agtaacagtc 12720 actatacatt aaaatgaaca agaaaacaat tacttacagc aatcattagc aaacagtgta 12780 agaaatctct acccaaacgt gttaagacac cacaaatctc taacagcagc acacagaata 12840 tatctgattg attaatatat acatgtatgg cttatttatt ggatctttaa agaagaaaag 12900 aattttttct ttactgtatt agtatcattt taatattcta ggatttaaaa gattactact 12960 tccatgttta acattttggg ctgggtgtgg tggctcatgc ctataatccc agcactttgg 13020 gaggccaagg cgggcggatc acttgagccc aagagttcga gatcagcctg ggcaacacaa 13080 Página 32

P201430887 ES 2 553 786 A1 09-06-2014 caagactcca cctctataaa aaatacaaaa ttagttggca tggtggtggt gcacgtagtc 13140   ttagccaaga ggtagaggtt gcagtgagct gtgactatgc cactgcactc tagcctgggt 13200 gacacagtaa gaccctgtct taaaaacaaa aacaaaccaa aaaaatcatt tcgaagtctc 13260 cagattttag caagtaaaat ttctgattta gtctgaaatt gggtttggag gagcacctca 13320 tttcccccgc caccgcctcc cctcagcaca gctcctgcct cgctgactct ggcatggtgt 13380 tagaggaaga gctctggttc tgtatcatct gaggtggtaa gccaggcctg gctattccag 13440 gccatttccc cacactctca ggctgtgctg gagaaaacaa atttaaagtc tgtcatctct 13500 agataagata aaactaagag aacagggtag aaaataccat aacaatatta gccccttgct 13560 accatgcagg cctggcctgt tcctgtgtct gagagatgtg gggtcaccat gcctccctgt 13620 caccctgggt cagtgcagtg gaccctgctg gcccatctct tcctccctgt caccctggga 13680 ttgaggacat gcatgctgat catacttaag gcagactgag ggatgctcaa tccttgcatc 13740 aagcctccct acaaaatcca gctctcacac tgcccggtca ggtagccagc accttgtctg 13800 ctcttttcac tttcaaagtg tgcaggcagc tcagatctgg taagcctcca ttatcaatat 13860 aaaagagcaa ctagaagagc atatatttat aagttaggtc tcactaaaac attaagacag 13920 tcagaaatga cacaatggat tccaccgagg atccacccag tccaccccac taactttagg 13980 ccacagaatc ttttggagaa tggcaggcca ttattccacc aacagaagtt ggaaatatag 14040 cctgttgatg cgtttaccac ttcttcaacc ccttttcagc ttagataacc acaagaataa 14100 taactaatgg catatttaat actggggcta tgaaagtttt aaattcatca tatcattatt 14160 ttattacatt ttaggagcat tccagggact tagtccatac ttattcttgt tattcacagg 14220 gaaatgagaa actaaatggt atcaggagct ttcttagacc tacttgattt cctttgagaa 14280 atgcatgtca ggtgtagagc aatggaggga aagcccccag ctgttaagta gtattactgc 14340 caagctacta ttagcagact gaccaggtgt actgatgtaa atcacttttt aaagtacatg 14400 ctttatactt gaattgtagg tataccacac aattacaaaa catttatata attatagtat 14460 caccttatat ggtacctgtc ttttaagaga atcaaactat tttttagaca ttctacaaat 14520 tctctgtgtt aagttttagc tgcttgtttg gcacttgggt tcttacacaa aggatgatac 14580 agtcagagca aaatcactga acacaatcac agccctccca gctcacttcc agccattatg 14640 agacacatgt ggcatgaatc actgtcctac tactgaatgg ctatgctctt ctcatcttct 14700 gtccttacac tgtttgttaa tgatgaattg gaagctctgt gataatcaag ccagcactga 14760 gagtgcagtt taactggatc actcagccag ctcaccatgc agggcaggca gtccaccatg 14820 tggcgcggct cttaccagtg ctgcacaaaa cctcttacac agttttgtat tacttttcct 14880 tccttttatg cagttccaac aactgcatgt tttaattagg aaaaacaaac taataaaagc 14940 ccagtgcact agacttggat ctcactgacg cacaggttca ctttgtggtg gggcctctct 15000 aaccctcact tgttgcatgg cataggcaag tcacctttct tcactttacg catttcctca 15060 tcactaaaag gagagtaata attcctgcta aatttacctc ttggaatcaa gagaggattc 15120 acaaaccatc ttgatgatcc accaagttgt taaattcccc tcacctcatt tttcagtgta 15180 Página 33

P201430887 ES 2 553 786 A1 09-06-2014 accaaaggaa aagagaagat acttttagtt ggcatcacac actcacaaac gaggatattt 15240   taccagttgg taacaaaatg tagtttcacc tcttctccta ggcttaccct ttcttggtga 15300 aacttttagc aatagtgata tatctggaat ttccagaggg tgagaaaagg aaagcacaaa 15360 gggccaagag tgagatgagg aaacgtgcag atacaagttt actgagcaac caaaatgtgt 15420 atttctgcca tggaaaaaca acaacaatat gagtaatacc agtgaggcat attaaacaaa 15480 gggagatttt tgtgaaatga atttgagaac aaaatcataa aatgaatgaa tctagagctg 15540 ctccttgaga aaatcagatg acctggattg gtaaagaggg acaaaaaggt cctgaagacg 15600 cttagtggcc tgtcatcatt cttggtaaac acagaaattc tctttgaaca atctggcaaa 15660 gagtaaagaa ctgagctatg ctcattttgc aatgaaaatc cttatcagag ttaccaacat 15720 gtcccagttt gcctaggaca ttcccagttt gggttctgaa atccccacat cccataatct 15780 catgatctgg gcagactgag atggctggtc acccaagcag ccatgcaccc ttggacatgt 15840 tgcaaaagac ttgtgcagag agcacactca cactggtacg agctcttttt actctctgga 15900 gttattagac ctcctctgga ggatgctgtc ttattgccct gagaaatacc caaaaaactg 15960 ataagagatt gagtcatttc tcaggatcca ttactatatc cccaatatct aaaatatgcc 16020 agaatgctga gggcacatgg taggattttt ttccttacag gcctctgttc tgggagaaat 16080 ggtaaacatt agtaaatatg aaagaaatga ggttttcaaa gtagacaaaa tcatgcaaaa 16140 gtatatttgg tgtgcactaa acatagtttt gtagagtaaa tagattttaa gataagataa 16200 agataatatc actggtcact tccctgaagg gaaataggag gctgagtaga ggttgaaggc 16260 ttagccatat gaaagtatta tctattcaaa gattaaaaag atgcacttct atctaaacca 16320 atggcacaac attaattatt atagctctgc acttttctaa ctcagtagta aaattttttt 16380 aaaagcttag attgggctgg gaaagttttt acatgggtga tctagtacac cactgatata 16440 aattgtactg atttccatca ttggctaatc actgtagaat actggtaaat caaatccact 16500 tcctaatatt gtgtaacttt ctatgcttga tcaagggtct gatcctgaac aacaacaagc 16560 taacgaagat tcacccaaaa gcctttctaa ccacaaagaa gttgcgaagg ctgtatctgt 16620 cccacaatca actaagtgaa ataccactta atcttcccaa atcattagca gaactcagaa 16680 ttcatgaaaa taaagttaag aaaatacaaa aggacacatt caaaggaatg aatgctttac 16740 acgttttggg taagtttttc aaatgaatgg gacatcttga aattataaca aacaagcaga 16800 tgtagaacac tttatcgtca ctattaagaa taatttccaa aattaatttt tgaataatct 16860 ttgcctagat aagccattta taaaccaatt aaaatgtcca acaaaatgtt tagcacttaa 16920 agaaaatatg atcttcgtaa tactgtctct ctctccctga agaacctcct ttgaggccag 16980 gcctggtggc tcacgcttgt aatcccaaca ctttgggagg ccaaggcggg cggatctcct 17040 aaggtcagga gtttgagact agcctggcca acatagtaaa accctgtctc tactaaaaat 17100 acaaaaatta gccgggtgtg gtgacaggtg cctgtaatct cagctactcg ggaggcttag 17160 gcaggagaat tgcttgaacc caggaggcag gggttgcagt gagccgagat tgcgccactg 17220 cactccagcc tgggtgacag aatgaaactc catctcaaaa aaaaaaaaaa gaacctcctt 17280 Página 34

P201430887 ES 2 553 786 A1 09-06-2014 tgaaacactt agcgtggttt ctgtttctga ccagacccta ataaaatata acttattatt 17340   taatttaaag gtagtatttt taatgtattg cataagctac tcaaatataa tacacaaaat 17400 tagtttggat attatttgga atgtgcacct aacatttggt tatctgcttt aagattatcg 17460 atgtgaggaa ttttttgtct tatatttaaa actctacctg attttatttc tgacacctat 17520 catataacca tgccatctcc ctataatatc cattcaaaat tcataaccaa gatactaatt 17580 catttattca tttaattcaa ccaagtgcct ggcctcactt actggcattt cttcaaggtt 17640 atatttctgc taacaaaaca acaatttcta attgacttac aatttaaaaa aagtttaaga 17700 cacaaaaatg tacacagaaa aacataaaca ttttggatta tatgaaggat gatctttttt 17760 gatgcactat tacaataaca aaaccttaat tgtgctcatg gttggaggag agtgaaaatg 17820 tcactgatat ggtaattcaa agtgaaaaat agtgaacttc tcatatattc cagtttacat 17880 aatacaaagc cgtatttttc tgatgctgac agaaaggaca gtagatagac agaagcagat 17940 ataccgagtg aaaatgagcc taaaggatga agctcacgct tcttgggata ttcattcttg 18000 ggatgtgtct ctctgcactg tgagtttcct ttatatacaa cctatgtgtg ctaagtcatg 18060 tcattctccc ctgacagaaa tgagtgcaaa ccctcttgat aataatggga tagagccagg 18120 ggcatttgaa ggggtgacgg tgttccatat cagaattgca gaagcaaaac tgacctcagt 18180 tcctaaaggt ttgtatttac tttatctaag atatggtatt ttaaagttgt cacctttcaa 18240 taacgattca atctaatatt gtaaactgtg cagtatacac tgcaactaga aatctttgca 18300 ccagtaaatc tggtcaatat agtctacaca cacataaaat gccatatgta gtgccttttt 18360 cctgacagaa ttaagccaca atttttttta ctccactaag aataaacatt aagaagcaat 18420 gaacttttag ttttccttct ctttcctgac atttactcat ttatacctgt cattctgtgc 18480 agtacctgtt agaggtagag aattctatac agaagaaagc agagaaagat agatggggca 18540 agagaccctg tccccaggca tttagccaca gtttgaggtg aagcctatga gcccagactg 18600 ggcagcccct ggctctggca ggaatggaca tgccattcaa ggcaaggcat tttgtaccca 18660 gcttcttccc aggtgtactg tgaagactaa tgggccaata cacagaaagg tctgaggaca 18720 acatccagca cgtaggaagt gaccacctgt gacataatca ttaccaagat gagcactgtg 18780 ctctttatca tggctttgtg tgacccaagg ctagcacctc aagtagaatg ctccttaagt 18840 ctgccagatg accagtgttc taacccatta cttccaagct ccctgtctga tgattagctg 18900 cataggattg cctttcttgg aactcttgct caaagtcttg ctttccttat tcccaacaag 18960 ggcacatgct ctctttgctt tgatgactaa ctgggccaaa aataacccct atgattaaca 19020 acatattttt actttccaac agctccgtct ttcagtatcc atgagttaaa gcagcaactt 19080 catcacgacc ccctctaatc tactcacctg atccagaaga tcaataaaac aaacatatac 19140 agataattta aaagacacag taaagctgtt attattaatc aagaggtgac ctttcactta 19200 ggtcacctaa agatcatcta aagtaaaaga ggaaaaataa cttttctatc caggaaaaca 19260 acagtttaat tcagaactat acaaatccaa aaaaacacct cagtgtagct ttaaaggagg 19320 tggatgtttt tctacaagaa accaaaaatg ttacatttac cttcccattt tagaaaaaca 19380 Página 35

P201430887 ES 2 553 786 A1 09-06-2014 acaaaaaatg caaatgctac ccaataagtt aaacatataa aatccctttc atctgctgga 19440   agataacatc cagtaaagga gagtgaagac aaggaaaaga ggaaggtaga gggaggagag 19500 gaggacagcc tacagggctg gaggagggag ctgctgttcc aggccacatc tcctgacatg 19560 gccattcttt atgttcacac caaaagtctt tcctacactg caaaattcta tttaaatttc 19620 aaagtgtatc ttaaaagtaa aggtttaact tctcatgagt tttcaagatt ctttcaaagc 19680 caaaaggaat ctttagaaat ttaaattgga atcaaatctc tcaacttaaa taactattcc 19740 ttcaaatccc cttgacattc agaattcact aacctgtgaa agctgactgc ctgcatggca 19800 taatccagtc agtattaccc cctgtggcaa gatgaaagga tgcaggtatc ctgagggtcc 19860 ttaccagacc caacaagtta tcatgtggac aggatgaaaa tgtcttcttt cctattcgtt 19920 caggaagttc tactgcataa tattatgtgg ggaagagggg agacctgttt gaagacaggg 19980 tgggaacaga aattccggta caaaagtgtg ctaacatttg tcagcagtta ctgagcttct 20040 gccaaattca cacctctgct cgttttatcc tagaggctac acttcaatct tctctctggt 20100 tacccacctt ccccatttcc taagggacac aacagttccc tcaacttcta caagtcctct 20160 cccagagatt attctcttcc aactttgtac aacctattct agattcgctg gcacgttgca 20220 ccagctattt ttctagtgat ttttgtatgt atgatggatc tgctctaaat tagcaaataa 20280 tgtctttgag gacagaacct ttaccttaca tactggaggg tccacataat cattccataa 20340 atacaattaa gctcaattaa tcaaaattca agaaattaga accttctcag tttagaagaa 20400 ttatttttct gctccctagt ttatttattt taaaattcaa aatagattct gttatcaaaa 20460 taaattcagt catggaaact attattgcta ttcataaaga tgtttcaatt atcttcatcc 20520 gtctttattg ctaatataga agggaaatat ttcatcaaga cttgaaaaaa ggagagcatt 20580 ttccagctag ctaaccagat acttgggttg acaaataata ctttgtatat agggctaaca 20640 aaatgaggtt tgatggaatc ttctggtcag tccctttcat tccagcttca gttcatttgg 20700 ggagagtggg ggtcaggata tgccccgttg agaagagaaa gaacgattat tcactgggca 20760 cctgccatgt gcgggggtac tacagataca cttagcttac acaaaaacta ctgctaattg 20820 aaagaataga gccaggcaca gtggctcatg cctgtaatcc cagcattttg ggaggccaag 20880 gtaggcggat cgcttgaggt caggagttca agaccagtct ggccaatatg gtaaaacccc 20940 atgtctatca aaaatgcaaa aattagctgg gcatggtggt gcacacctgt agtcccagct 21000 acttgggagg ctgaggcaag agaatcagtt gaacctggga ggcggaggct gcagtgagcc 21060 aagactgcgc tactacactc cagcctgggt gacagagtga gaccctgcca caaaaaagaa 21120 aagaaaagaa aagaaagaat aaatactgca atgacctgaa catatcaaat agggtaaaaa 21180 tccgtgttta taatggtgtt ttaaaaaaaa cacaaaaaac cttaactggt cacctctggg 21240 cattgcatga attcattact tgaatgaatc aagttttgct gccttttcta taaaaacaat 21300 cttacaaagt aactaaataa ttaatgaaag aaaattcttt agagaagaat tccagctaat 21360 aaatccatca agaatgacat caggaagtca ccattttcca attcctaatg acagaatgga 21420 tctaggcaac aatcgtgcat gaatgctaag accctcaggt gaaaggctga tttgctttta 21480 Página 36

P201430887 ES 2 553 786 A1 09-06-2014 tctgaatgtc tctctgcatc tgactaccag ggcataggaa gaagttaaag gatcctgata 21540   aatgatatca catggaagct gtcagccaaa tccacaaaag gagtgtctca aacaaattaa 21600 tatggaaata aatcaaaaga agagggagaa aaaaggaggg agtatgttgt acattaagag 21660 agatttcaag agcgataaga accaaatgta ttctgtaaac ttcatttaat cctaacttga 21720 acaaatcaac tgtaaaatga cgtatttgag acaagtgggg aaactttact atattagatg 21780 acagtaaaga atgtattaat cttgttagat gtgatattaa cagggtggtt atgttaaaaa 21840 acaaaaaaca aaaaacaaga tgaccttatc agttagagac atctaattga agaatttata 21900 gaagaaatga cattatgtat aagatttgac tttaaatact ccagcaaaag aaatatggca 21960 aaataaaaat agataaacag atcaataaat aattaagagt agataaaaca agataggaaa 22020 aatggagata actgttgaag ctgagcatgg tggttcataa tactagttac tattttatga 22080 atggttacaa ttttaccata ataagaagtt aataaaaagt aggtaccagg ctgggtgtgg 22140 tggctcacgc ctgtaatccc agcactttag gaggccgagg ggggtggatc acctgaggtc 22200 agaagtttga aaccaacctg gccaacatgg tgaaacccca tctctactaa aaagtacaaa 22260 aaattagcca ggtatggtgg tgcatacctg ttatctcagc tactcaggag gctgaggccg 22320 aagaactgct tgaacccagg agatggaggt tgcagtaagc tgatatcacg gcactgcact 22380 ccagtctggg caacaagagt gaaactctgt ctcaaagaaa aaaaagagtt agtgcctaaa 22440 aagttgccta aatccataat ctgaaacttg aaaagtaaac aaatagtcaa ttgggcttag 22500 tgatacttga cttaacatat atatttctct tcttattagg cttaccacca actttattgg 22560 agcttcactt agattataat aaaatttcaa cagtggaact tgaggatttt aaacgataca 22620 aagaactaca aaggtaaacg ttcccaaaat tttaacttag aatgatacct cctggagaat 22680 gtgcacaggg accctggtag agatcactgt ctgtttagcc agttgctgtt ggaactggag 22740 agtgtgaagg gaaaactaga aagaaccaca attggccggg tgtggtggct cacgcctgta 22800 atcccagcac tttgggaggc caaggcgggc agatcccgag gtcaggagtt cgagaccagt 22860 ctggctaaca tggtaaaacc ccatctctac taaaaaatac gaaaattagc caggcatggt 22920 ggagggcgcc tgtaatccca gctactcggg aggctgaggt tgcagtgagc caagactgtg 22980 ccactgcact ccagcctggg catgggcaac agagcgagac tccatcttaa aaaaaaaaaa 23040 aaaaaaaaaa gaaccaccgt tattaccacc tctgctgata ggggcgaatc aagtgaaaag 23100 aagaaaatga cttttcaaat ttcccttttg ttaaatttag gtcaaagaat tttctgacaa 23160 aactggaaga tagttgttac atactgaagt aggttattaa ataaagtaat gaaatatctt 23220 tgaacatata tataaatagg acaggcttat attctaacta gtttgcggtg ttttcagcta 23280 actctatcac acctaaccat ctgtgtaaga cttgatgcat tttatatcat ttttaggctg 23340 ggcctaggaa acaacaaaat cacagatatc gaaaatggga gtcttgctaa cataccacgt 23400 gtgagagaaa tacatttgga aaacaataaa ctaaaaaaaa tcccttcagg attaccagag 23460 ttgaaatacc tccaggtaaa acattctact tgtgttcagt agatattggt atttttcttc 23520 agtttttata acacacttta gcacacctca agcaaagacc aagtaagcag caagggtgat 23580 Página 37

P201430887 ES 2 553 786 A1 09-06-2014 tcaaacataa tgactctcca ggttgcatga ggtgttttaa gaagtaggag agctttagga 23640   gaatggtttc tacatcgacg tcacaagaaa gctcaggatc catttccatc ttttggtttc 23700 tcctgttgaa actgctgagg acattgcggc aaagccgctg gcacagttaa tttcagattt 23760 tagggcaggg gtggctacgc agaggcagga ctggtcagga ggacatggag cagtgtcacg 23820 tgtccttttg atctggaaac atttctcaag gcagagcaag aggattaggc tcctggtatt 23880 ttcgctttca gtgtggtgct aggatagaca tgtatatttt tttttaaaca ttccaaccag 23940 aatacagtat ataaccaatt taaagtcacc atctggagca tcatgagttc ccattttgtt 24000 gtttgttttt attcattatt agaaatcttt tccttctatt tgacaactct taactggctg 24060 gaaggggcca cagattcctt ggagaatcta ataaagattt agatcttccc aagaacaaaa 24120 gttttcatct tccaaggagc ttgagaacaa aactgggcaa caagccactc tgcctcttct 24180 ctttttcttt ccggtgtatc tttaaacaag tttcgttcac tgtactcctt tgagatacaa 24240 accatcaaaa tgaatgtaat ataggcaggt gctaatctca agatcacaac ttttgctttg 24300 acttttccaa atgctgcatt tggatgtctg tttagccagt gactacaact tgagtccgtc 24360 ctctctcaag ctgccccatc cctgatgtca tttctgctta atttgctcca caactctgct 24420 tccagcttct ggtctctctt aaatctacct atactcttgc tagcattaat taaatgaata 24480 gaattataac acaaacagaa gaacacatgt cataagcata tatttcaatg aatgtccaca 24540 aagtaaacac actgatgtcc agcaggtttt cattcccagt gagatcagta ctatggtaaa 24600 ctataccttg cacttatatt gagcagctgg gggactgaac accaaactta aatgttttag 24660 caatgcctag aattttcatg attggtctca tatcagtctt actaagacat aaaggcagaa 24720 tctagaggta acaacagcca gggaggatat cccacgttgg ccagcaaaag acttctgctc 24780 ttcagtacac aaaaatgctg tcagttaagt agattgcttt tatttcccag aaatctcact 24840 gttaccaaaa aaggccaaag aagaaattag aagggctgtt aaagggaatg agggaaagtt 24900 cctctattta ccatactttt tgagtaagaa tttaatttaa aaagacatgt acacggcctg 24960 taaaattgtg acttgtccac tggtgtacat aagatcaagt gatttcaatt attgatgcta 25020 tattacaatt ctgcatttag gatgttgata gatctttcta caaaacaact tagaaaaatt 25080 ctcctttggt cacagaaaat gctagctaat aattcttcac aatcaaattg tgagcctaat 25140 tcttagagca ttaaatttca ttcttctgat catttctaat gttttaaatg cattattgta 25200 aatatggcac tgaagtaacc atatatatac acataaatat gtatatttaa aaatatgtat 25260 gtttataaaa gtaaacatta cgcatgtatg tatttatgta tatatgtatg tatgtacgta 25320 tgtatgtatc tatctatcta tctggagaga gagagagaca gcgacccatg tgaccaggca 25380 gtatgctctg ggccctggcg ggagtccttc cccaacactt ttgtgtacaa cacatgagct 25440 tgagttttta taataggtat ttaacatgca taagtgagta catctacttt acctgaaaat 25500 acattcaagc caatgtaaaa taaacagatg aataaaccca caaacaaatg gcgactacag 25560 agtatcttcc gtttacattt actgggtatt tttaatcctt tcttttttcc tactacaaca 25620 gataatcttc cttcattcta attcaattgc aagagtggga gtaaatgact tctgtccaac 25680 Página 38

P201430887 ES 2 553 786 A1 09-06-2014 agtgccaaag atgaagaaat ctttatacag tgcaataagt ttattcaaca acccggtgaa 25740   atactgggaa atgcaacctg caacatttcg ttgtgttttg agcagaatga gcgttcagct 25800 tgggaacttt ggaatgtaat aattagtaat tggtaatgtc catttaatat aagattcaaa 25860 aatccctaca tttggaatac ttgaactcta ttaataatgg tagtattata tatacaagca 25920 aatatctatt ctcaagtggt aagtccactg acttatttta tgacaagaaa tttcaacgga 25980 attttgccaa actattgata cataagggtt gagagaaaca agcatctatt gcagtttctt 26040 tttgcgtaca aatgatctta cataaatctc atgcttgacc attcctttct tcataacaaa 26100 aaagtaagat attcggtatt taacactttg ttatcaagca tattttaaaa agaactgtac 26160 tgtaaatgga atgcttgact tagcaaaatt tgtgctcttt catttgctgt tagaaaaaca 26220 gaattaacaa agacagtaat gtgaagagtg cattacacta ttcttattct ttagtaactt 26280 gggtagtact gtaatatttt taatcatctt aaagtatgat ttgatataat cttattgaaa 26340 ttaccttatc atgtcttaga gcccgtcttt atgtttaaaa ctaatttctt aaaataaagc 26400 cttcagtaaa tgttcattac caacttgata aatgctactc ataagagctg gtttggggct 26460 atagcatatg cttttttttt tttaattatt acctgattta aaaatctctg taaaaacgtg 26520 tagtgtttca taaaatctgt aactcgcatt ttaatgatcc gctattataa gcttttaata 26580 gcatgaaaat tgttaggcta tataacattg ccacttcaac tctaaggaat atttttgaga 26640 tatccctttg gaagaccttg cttggaagag cctggacact aacaattcta caccaaattg 26700 tctcttcaaa tacgtatgga ctggataact ctgagaaaca catctagtat aactgaataa 26760 gcagagcatc aaattaaaca gacagaaacc gaaagctcta tataaatgct cagagttctt 26820 tatgtatttc ttattggcat tcaacatatg taaaatcaga aaacagggaa attttcatta 26880 aaaatattgg tttgaaataa aatatttgtg ctttgatgtt atttttcttc acccacccag 26940 caatataaac tattcttcag aaaactctaa tctatatata acatgtttag agcagtatta 27000 atgtcaatta ttattacttt ttgttttgtt ttgagatgga atctcgccct gtagcccagg 27060 ctggatggag tgcagtggcc tgatcttggc tcactgcaac ctccgcctcc tgggttcaag 27120 cgattctcct gctccagcct cccaaatagc tgggattaca ggcacatgcc accatgccca 27180 gctaattttt tgtatcttta gtagagacgg ggtttcacca tgttggccag gctagtctcg 27240 aactcctgac ctcgtgatct gcccgcctct gcctcccaaa gtgctgggat tacaggcgtg 27300 agccactgag cctggcctaa tgtaaattct taataacaat aatacatgtt attaatacat 27360 ataataataa caatacacca tgtaattcct atgctatgaa agataatcac ctttatatta 27420 agctacatca aaaacaagat tttaaataac ttgggggcga gggggaaaga acaacattac 27480 agatatacaa gagatggagg tt 27502 <210> 6 <211> 50674 <212> DNA <213> Homo sapiens <400> 6 ctggatgtat aacatcatag ggtagctgaa gactctttgt gaggccagag ctttaggatt 60 Página 39 taaaaagcca ccaaccatga ccgtgtccga cacgttctac agagaactcc taggttactg 120 ggtgattgtt tggtggggaa gcggcgagtt gtcttttttt caaaagacgt tttggggtat 180 ggagtttgct cgctctgcat acagaaggaa ttctagaagc tgggatcgca ccacccaccc 240 cacgcacccc ttacttgcag aaacctttgc cccccaaccc ccacccccac cccaaataag 300 ggctcttcaa ggggcagttg ccagctccag agccagctgc ttgacaccta ttgtccccgt 360 ttgggcgtca aacgatttcg cctgaaggac cctagcgtcg attgctctca aaactcaagg 420 ggcctttcct tcggccttgc cggggccatc cccacctgcg tccaggaggc gccccacagc 480 gccggggccg ggggacggcg gagaagctag cgggcggcct cttccgggca ggcgttcgcg 540 ccgggcagcc cgagcggccg cgaaggcccc cgctctccgc ttctcccgcc cctcgcgacc 600 cagagggctg ctggctggct aagtccctcc cgctcccggc tctcgcctca ctaggagcgg 660 ctctcggtgc agcgggacag ggcgaagcgg cctgcgccca cggagcgcgc gacactgccc 720 ggaagggacc accacccttg ccccctcagc tgcccactcg tgatttccag cggcctccgc 780 gcgcgcacgg tgagcgccac ccgggaccga gccgctgcag gggaagaggg ccgctgcgcc 840 cgggtgtcct ttatctccgg acccgctgga gcttccgagg ggcttgcccc caagtccccc 900 caccccaccc cggtcatttc ccatgccctt ctctgccccc aagccccgac ctctctcttt 960 cctcccttct ccggaagccg gcaaaagccg gccctccccg gtagggaccg ttgcagtggc 1020 cgttggcggc cggcgcggcg atgccccgcc tccggcgcga gcctcggagc ccccgggctg 1080 gtaggccgag ccggcggctc cgcgggggag gggcgggtcg gggggcggtg cgaggcccag 1140 ccgggcgccc cgctggcggg tcgcgcgcgc gcccgcgcac tcttcctgcc ctcgaggcgc 1200 gccgcgcccc ctcccccacc cgctcgcgta ggctaccgct cgctgcgcgt tttgtcccgc 1260 gtctcgcccc gtccgtctcc tgactggccg ctcttgtcct tcctcccgct ttttcttctc 1320 tctccttgcg gtctgaagat gccctcggcc accagccaca gcgggagcgg cagcaagtcg 1380 tccggaccgc caccgccgtc gggttcctcc gggagtgagg cggccgcggg agccggggcc 1440 gccgcgccgg cttctcagca ccccgcaacc ggcaccggcg ctgtccagac cgaggccatg 1500 aagcagattc tcggggtgat cgacaagaaa cttcggaacc tggagaagaa aaaggtgcca 1560 ggagttggcg gggaagggag gggtggctgc ggccgggctc tgcggcccct ccgaccctgg 1620 tcgctggagc cttcgcttct tttcgtctcg ggagcgttac taggtcccct cctcccaccc 1680 cctggcccac acgccccgtc tccacgttca gcgggagctt cgtgcccaga aaacgggctc 1740 ttggaagagg cacttgtcac ctgactcgga cgcggcactg taccccaggc ctctttatta 1800 ctcttccgct gtgggtccgg ctttttggcc tttaggagtg ggacatgtga gggtgggggc 1860 ctgtcgtcag gacttcactg tatggtgccc ttctttccgt ctctgaggcc cgatttctct 1920 gacgagggcc caaaatgaag aggtccctgc gcggggggct ccgggttcaa ccgaccgcct 1980 cgtggagttg gggcggcctg cgtcctgcag ccttggggtc tgtccgctcg gttaccatgc 2040 actcgagacc tgtcgagcgt cccctcttct tccgtaggag agaagtgtgt ttagaatctt 2100 aaggtagaac tgcctttccg gcaggcccat tttgaatggg tcttcgattt gctacccccg 2160 Página 40 cgcccatgcg atgggctccc ctgcgtttcc ctctttgttt caattgttta ggtgtccccc 2220 cgagcctcag gctcagctca atcgcgagat gattttctgc agcgactttt tgttcctagg 2280 ggactgtgaa ggggcggggg actgccacga tttagattcg ttgggggctg ggtcctgggg 2340 agactggaga ggatggctgg gactcggggc acatggagag agcgtctaac atggcggcgg 2400 ctgcggggag agggaagcgc tttactggag ctgcattgtg agcacaaagc gaaagcagag 2460 ggggagggca gagaccaggc agccgccccg actggcctcc ttaggccccc ctctaaaaaa 2520 aaaaaaaatc gagccacacc cacgattttt tggattcaat atttagtcct tgtagatcaa 2580 actactgagg tatatcttca tctgcaagtc agccttttgt tttatgcttt catcgcagga 2640 cagtgtaaac tcttgtttag aggggcgtgt gtatgtatgt agagaaaagg tctgggcaga 2700 gtgaataatt aaaatgagta agatcagagg tggaagggga gaaacaaatt agtcgtttgt 2760 aaaaacgagg taattacgtc tgtgactatc atgttaactt gaattttacc ttataaagta 2820 aaatgaagcc ttgataactt ctacttgtct gcctctagga aaacatattt ataacatctt 2880 gaatttccag gaaatcattt tgcagtgttt atgtggccag acacctaata gtgttacttg 2940 aggtgctgat atagtaactg gctaaaactt gggctgtggg aaataagttg aagaaaactg 3000 gtgatgttta ggtcttatta attttactta tatattttac attttgggag agttttaaaa 3060 catttagatt tgatacttcc ctgtttcatc ttcggtattg aaggttggaa gttttacttg 3120 aatttcatgg acttgggatt tctttttttt cccaatcctt tattttgata aatgtatgtt 3180 ttattatagg taattggaat agtaaatgta gttacatcaa gaaagtaaca aaagtatttt 3240 aagtgtaagg tagctacatt caaatgttga atggaataag catgcccaag gccagtatct 3300 tctgagtctg acacatgatt tagtttaccc tgttgggtat cttcttaaat tttttttttt 3360 ttgagacgga gtttcgatct ttttgcccag gctggagtac aatggcgcga tctcagctca 3420 ctgcaacctc cacctcccgg gttcaagcga ttctcctccc tcagcctccc aagtagctgg 3480 gagtacaggt gcctgccacc acgcccagct aattttttgt atttttagta gagacagggt 3540 ttcaccctgt tggccaggat tgtctcgatc tcttgacctc ctgatccgcc cgccttggtc 3600 ttccaaagtg ctgttacagg agtgagcccc tgtgcccggc ctctttttaa aattttaatg 3660 cagtaagcaa gcctgctgat ctggctgcta cttgagtttt tgattcttta gaatttcttg 3720 gaaatgtttt tttctaggac agtaattgaa cataaaatat taatgattgt gaacattaat 3780 aatgtgttaa tactaattat gaacattaat gattagtgat ataaagtgta gagacattaa 3840 tgactgaaag ataactcctc agagaagtta atataaaggt aggtgctgat tggcagccaa 3900 tttagttgtg aggtggctgt tagaatctag tgttcaagta cttctgaaaa aaaaatataa 3960 atctagttta taagcccctc ctgaggactt gaaccatgac tggtcattaa atgtgtatag 4020 gtgtatgtga attactatac tctgtcatac cctaccctca agtgattttg ttattttatt 4080 tttatttttt gagatgaatc tctgttgccc aggctggagt gcccaggctg gagtgcggta 4140 ggatgatctt ggcttcctgc aacctccacc tcccgggttc aagtgatcct cccgcttcag 4200 cctcctaagt agctgtgatt acaagtgtgc gccaccaccc caggcaattt ttttttcttt 4260 Página 41 gagaagtctc gctcttgtcc gccaggctgg agtgcgacga tgtgatctcg gttcactgca 4320 acctccgcct cctgggttca agcgattctc ctgcctcggc cccccgccca gagtagctgg 4380 ggttacaggc acctgccacc acgcccaact aatttttgta tttttagtag agacaggttt 4440 taccttgttg gtcaggttgg tctagaactc ctgacctcag gtgatccagc cgcctcggcc 4500 tcccagagtg ctgggattac aggtgtgagc caccatgccg ggcctcccct aaagtcataa 4560 aggagaaaat aatgtaatta ttacataggt tattaactag gctaatacat actgaaagat 4620 tgccgtgtta ataatggaga ttcaacaaac tgcacaaagt aacttttttt tctgtcttct 4680 cagtgtttta agtggtagat agcagcaaaa aggtcaagtt acagttaagt cttgagactt 4740 tgataagcca cagactgaac tctacctaca tgttaagtag ttaagttggc agtattgatg 4800 ttgacttaat tgctattaaa actatatctt ttgccctttg aaaaacccag ggcatttgga 4860 tttgccctaa atttaagcac atctggtttt tagtttaaat cctttttata tttagatgat 4920 ttacttgtga gaagacttaa ctgtttttaa gtataagtga gcatttctaa tgcactaaaa 4980 taggattgct ttacaaatca gttttgaatt cctctttaga aacccttgtg gagtaaagtg 5040 aggtactatt tacaattaga tttgttttga cttcagtcca tttagcaact tacatttgag 5100 ctttatttca atcttgacct attcttatcg gagccttctg gaccaaaatg ctttttttat 5160 ggattttaaa atcaaatatc ctggcaaaaa tgactatgga tatgtagtat tgcttaaatt 5220 aaaacagaga attgaaataa ttttattgta ctttaaaaaa caaagttgtt tatttcctaa 5280 taatttgagc cattaaagaa aaagctaagc atctgctcat tgagaatgca tgctcttaat 5340 gttgatgaaa tatgatcgtg ttatgtaatg caactaaaag gcttggtggg tttttaaatt 5400 caggcttata aagagtacat gaatgtttag caaagagaag aaatacagct gtgataatca 5460 agtgtaaaat ccatttgcaa atcttacagg taatattgaa ttgaatgatt aactgcctag 5520 ttttctttat cagttcattg gtgctgaact gggccctagg ctatgcaaga tatttcaaaa 5580 ccaagtctta attttaactg aagagagacc tcatttgata ttattagatg taatcagttg 5640 tgatatagaa taaaggatgt tttaatagat gacatttaaa attgttatat tctttgtgaa 5700 tataataggt ttagactcta gtgactttgg taggtgaaag attaactaat gatcacttgc 5760 gtaaaatgca aaaatagcct gacagctttt taaccactaa gtgaccaaaa ctgatagcca 5820 gaagtgtagt gtttttaata ctttttcctg aaggctttct gcacttcatc tttgcagtta 5880 gtagtattct ttaaaaagaa tgctgttgtt gtgagggtaa catttctttc tagaacgttg 5940 cagtgtgtct gtgcttagaa ttttcattgc agctgttgtg cagaacttat gtgttcagtg 6000 ttttaaaata aaaacattct taactatttt ataagtaaaa tctttccttg aggctattac 6060 ctgaagcctt ctttgacatt taagatctct tgatgtgttt gcttttccat gggttgcaag 6120 aactattctt ctgcaatgca gagggcaaga ttattttgca ttcaccttgt catagaaaaa 6180 agctgtaatg cttaatttgt ttccctttgc ttgactgtgt gtgtttgtat gtgtagcact 6240 gggaagtatt taaagctgtg aattccccca agtgataatg ggtacctttt tctagggtga 6300 gagtcgaagc ctaagtatta cattgagaat gtattgtttt aacgtggcca aattagtgta 6360 Página 42 ctctaggata ctacccatgt ggcagatatt tgagaatgca ttttgtgtga cttacagatt 6420 aagcatacaa tttgccaaaa ttttatgtaa ttaatttcct agtttacatt tagggctaga 6480 tgaagactag tactgtttca tcttttagaa aaactaacac ttttccttta gtaaaagtgt 6540 taatttttgc aatacttttg caaaaggtta aacttatagc aattttgtca tagctataat 6600 cttacactgt tataaaattt agaggatttt taatttttat ttattatcat tatttgagac 6660 agttttgctc tcgttgccca ggctggagtg taatggcatg acctcggctc actacaacct 6720 ccccctccca ggttcaagct attctcctgc cttagcctcc tgagtagctg ggattacagg 6780 cgcccgccac cacgcccggc taatttttta tatttttagt agagatggga tttcaccatg 6840 ttggccaggc tggtctcaaa acgcctgacc tgaagtgatc cacccacttc agcctccaaa 6900 gtgttgggat tataggcatg agccaccatg tccggcctaa gagttttttt ttagagctta 6960 aaccacctta gaatttagtc cagttcattt tatagaagac aaaattgaga tgtttatatg 7020 gaatgactta ggttggaatg ggtgatttcc aaaattctcg cagttttttt tgaaacagaa 7080 tcttgctctg tcgcccagga ctggagtgca gtggtgcaat ctcagctcac tgcaacctct 7140 gcctcctggg ttcaagtgat tctcatgcct cagcctcccg agtagctggg attacaggtg 7200 catgccacca cgcccagcta atttttgtat ttttagtaga gacggggttt tgccatgttg 7260 accaggctgg tctcaaactc ctgacctcaa gtgatctgca cgccttggcc tcccaaagtg 7320 ctgggattac aggcgtgagc caccacaccc ggcctcttaa ataatgtttt atgggagtaa 7380 ttagaatttg taatgttcca cggcctaagt gtagttttca tgtttaatta tgtagaatca 7440 agtaaagcct tttgcttcaa atccttagag tttttctgtt ttaaaaaact gaatgcaaaa 7500 gaaaaatgct ttccatttcc ttattattag acttttatta atgtctcatt gttgaacttt 7560 gtgtttgcat tgtccgggta atggggttct gagaatatcg gtaaggtaaa atcccagtgt 7620 gtcaggtatc attgggacat ccatattgta atgaaataaa cttttataaa gttaaaactc 7680 tgaagttttt ctttatgttt agcttcctat gtacatttgt cagactctac tccagcttgg 7740 tatgttgtag accggaaaaa tctggaaaaa gcattaccag tagagagaaa taagaagtgt 7800 gacaaccttt tcatccaaat tactgtattc caagcttctg ggtatttttt ggtagttggt 7860 tcctttttct gggggaaatg aatggtgtgt gtgtatacag tatagaagag tgagaggagt 7920 agcagaagag aaattcatcc aaagttggaa ctgtaaattg ctttgtttta gctcatttat 7980 ttctttcttt cactagctct actacagtgc ttttgttaga tagactatga gtacaaaaac 8040 gtgggtgaaa gataatttac tgagtagagt tcaaaattca aacttcctga ggaaagggga 8100 gggtgtgctt cttgaccatg ctcagctaaa gtagtttgtt tcctttaact tcccctgtta 8160 cctattgtct gtacacttct tgacattgtt tttttttttt ttttgagacg gagtcttgct 8220 gtgtcgccca ggctggagtg caatggtgtg gtcttggctc actgcaacct ccgcctcctg 8280 ggttcaagtg attctcttgc ctcagcctcc tgagtagctg ggactacagg tgcatgccac 8340 cacacctggc taattttttg tatttttagt agagacgggg tttcgccatg ttggccatgc 8400 tggtcttgaa ctcctgacct tgtgatctgc ctgcctcggc gtccaaaact tcttgacatt 8460 Página 43 tttatattgc cttgtgttgt taaccttaca tgtttttcta aattggtaat aagctctttg 8520 tgggcagaga ctattaacat tactttgctg cgctttctca cacatggtat atgctgaata 8580 agtacttggt agtttggcca aatcattaca tagaaatatc tgtagcttca ttaacaaccc 8640 tgttaaaatg gattaatcca tggggttagg gaggaaatgc tttttgcaca gaactattta 8700 cttgcagtgt ttttttattg aaattgattt ttttcctgaa gggtttttta ctttttacag 8760 gtgtgtagag ttgatgagta ggcaagtaga agaatacttt tttttttttt ttttttttaa 8820 gctgggtagc aggctgggca tggtggctca cgcctgtaat ctcagcactt tgggaggctg 8880 aggcaggtgg atcacctgag gtcaggagtt cgagaccagc ctggccaacc tgtgaaaccc 8940 cgcctctatt aaaaatatga aaaattagct gggcatggtg gcatgcagct gtagttccag 9000 ctacttggga ggccgagaca ggagaattgc ttgaacctgg gaggcagacg ttgcagtgag 9060 ccgagatcgc gccactgttc tttagcctgg gcaacagagt gatactccat ctcaaaaaaa 9120 aaaaaaaaaa aaaaaagctg ggtagcatta gcaagatatg tgaatggtct taagagaaca 9180 cagataattc ttattattag aaccattgta cattattgga aatttcattg cattctcctc 9240 aatactgttc taaaaatatt ttaattttaa ttttttagag acagggtctc actatcaccc 9300 aggctggagt tcagcagggc aatcatagct cattccaacc ttgaactctt agccttaagc 9360 gatcctcttg tctcagcctc ccaaagtgtt gggattacag ggttgaccca ctgtgcctgg 9420 cccccctcaa tactgttatc taaacataga aataactgaa atatatttta gtcattaaaa 9480 aaccctttgg gcttacactt tgagttacat tgaacttctt tttacattgt ggacaggaaa 9540 gatagtaagc aaaagtttcc tcaattttta aaaggacgac ggtagaaaga acacattgca 9600 atctatagat gatccatggc agctatcttc aaatgctgaa agcttgctca tgtagcagga 9660 gtctgtgctg ttttagaaaa cgaaaaagta ttaaaacagt gatggtgggg atgtaatttt 9720 tttacattta actcccaagg aatgtattaa tataaataag ttgtacagaa ttatgctaag 9780 gaatagcttg gttaaagcaa ctaatatttt gaaagatgcc ctttaagatt atttatggta 9840 atttgctttt caaatctaga agctttagac tttttaagaa tatagttcaa agtaggtgat 9900 gctggaactt gttaacattt ctttttccta ctagagtcag ctgcttcaat tcactcagac 9960 ttacctgcat aattataacc ttggacaagg aataaaggtt tttacaggat tggcttttat 10020 cttttttaaa aaattggaca aacggcttgt gaaactaaac tcctggatac ttaacctgct 10080 tgaaaaatta tcttacaatg gaaccttagg taacatcctt tttttttttt tttttttttt 10140 tgagatggag ttttgctttt gttgcccagg ctggagtaca atggcgcaat ctcagctcac 10200 tgcaacctct gcctcccagg ttcaagtgat tctcctgcct aagcctccca agtagctggt 10260 attataggca accaccaccg cacccggcta attttctgta tttttagtag agaccaggtt 10320 tcatcatgtt gcccaggctg gtctcaaact cctgacctca ggagattcgt ccactttggc 10380 ctcccaaagt gttgagatta caggcatgag ccactgcacc tggcctaggt tagcattctt 10440 atgccattct tagcgttcag aaatccagca ttcctgacag gtgttcattc agcctctgct 10500 ttaaccagtc ttccagggcc tggtagagtg ctcgtttctc aatgaaaatt tgtttcattg 10560 Página 44 gtgtgccact ctttaagttc ttggtggtag aagtatatcc ttaccggccg ggcacaatgg 10620 ctcatgcctg taatcctaac acttttggga ggctgaggcg ggcagatcac ctgatgtcag 10680 gagttggaga tcagcctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaat 10740 tagccgtgcg tagtggctta tgcctgtaat cccagttacc tgggagtctg aggcaggaga 10800 atcgctggaa cctgggaggc agaggctgca tgagccaaga tcgcaccact acactccagc 10860 atgggtgaca cagcgagagt ctgtctcaaa aaaaaaaaaa aaaaagtata tccttaccac 10920 cactgtttaa tagtctttgt tttctggaac agcatagact cccgctacat gagcatgctt 10980 tcaacatttg aagaaagctg ccatggatca gctatggatt gtagtgtatg ttctttctac 11040 cctgctttta aaaattgagg aaacttttgc ttactatctt ttttgtcttc tggggatttc 11100 actagctaac aatactcagt tgaatttgtg gagggcaaat aggagacagt cagctgccta 11160 ccattgtggg caaagtcaaa actcgtaatt gtctaagtga agaacagaga atgtggggat 11220 tggggacttg aaataatacc tggaaaaact ggtaaagatt ggaccgggcg cggtggctca 11280 cgcctgtaat cccagcactt tgggaggccg aggcgggcgg atcacgaggt caggagatca 11340 agaccatctt ggctaacaca gtgaaacccc gtctctacta aaaataaaaa aaattagccg 11400 ggcgtggtgg tgggcgcctg tagtcccagc tactcgggag gctgaggcag gagaatggcg 11460 tgaacctagg aggcagagct tgcagtgagc tgagatcacg ccactgcact ccagcctggg 11520 cgacagagca aaactccgtc tcaaaaaaaa aaaaaaaaaa ggaaaactgc taaagattat 11580 ggaaagttga gaggaaaaga aatattttgt ttttgcaaaa gttggtacag tactctagaa 11640 gtgatttatt tggcctggat acataaagta tagctaggtg ctcttaacta ctttggttat 11700 tttaggcttc atttttaagt attccctctc agtttagaca tctccttatt tgagaatagg 11760 agttacgaag ttttcctgga aagccaagtt agtttttttc agatgtttcc tcctaatctt 11820 ccttctgact atttaaaatt gtctagttga agaattttta gggttttttg gagtttatca 11880 tctctctttg ctatttattt ttaattgcat aattaaaaat ttcttcttaa attttttatt 11940 tgtggaattt gttggctata acaataaaga agcaaagccc aggaggacat ctatcatgga 12000 tatccctctt ctggcaccct aatggcacct actgaactta atttaaaaaa tccatttcaa 12060 gaaagtaact ttggtggtga tgaaaaactt cttgggaaga atggaagatc tagatgtatt 12120 gcaattcagc acaacataat aatctgattg gagaaaggaa gaaaacagca gcagcagagg 12180 cagagctgga atgtagcaac agctggaatc cagaatgaca ttctaagggg gagggttgtt 12240 aaggcacaaa tgatttttct gggatttaag accttactta ggtaagttat ttaactgtgt 12300 ctttcaattt acagttaggt gaaatatgat tgatagtaat gcctccctga taggtttagc 12360 taccttttaa atttgaatgt ctgttacata gtgaatactg tcaactatta aaagcagtaa 12420 agaaacagga tatagagcga gactggatag cacttgttgg gataattatt tcccagtacc 12480 acatgactct gacatctact gggtgtggtc acacctctcc catgattccc ccttaaagac 12540 tctgggtaat ctgggaaatg gcctgatttt tatcttgctc atatgtgtgc tgtaaatgga 12600 tttttaatac acttaggata ctcagctgaa aaggaactct aaattgaatt tcaagttaga 12660 Página 45 aaggatctaa gagggcaggt gtgtgttatc aacattgtaa cgtagtaggc tttctgatga 12720 agatagtttt tttttgagat ggagtttcgc ccttgttgcc caggctggag tgcaatggtg 12780 tgatctcagc tcaccgctgc ctcaccctcc ctagtagctg tgtttacagg catgtgccac 12840 catgcctggc taattttgta tttttagtag agacggggtt tctccatgtt ggtcaggctg 12900 gtcttgaact cctgacctca ggtgatccac ctgtctcggc ctcccagagt gctgggatta 12960 caggtgtgag ccaccgcgcc tggcctgaag atacattttt atgctaggaa aatggtttca 13020 ttctctagga aaaatactta atatcttatt ttatttgttt catgagtagc tgaccaattt 13080 attgttacct cttctgctgc tgttagccat gttccagccc aggaaagaat aaagctgtgt 13140 ctgtctggag ccctttatta ctcctatctt accattctgt tcttagtata atgttggatc 13200 tgtcaatgtg acaagctatt ccttgtatat tcgcttagtt catgctgtaa attttaacac 13260 cagtggacaa attttctagt tggactttaa tgtaaaccat ttgaatagga agtgacaata 13320 ggaatgaagc cacttaagat ggcatcattt ttctcttgag tagtctgtgc tttcaaagat 13380 taggcaaatt gtatttggag aagtgcagat accatatcct tttccttatc atggaaggcc 13440 acttaaggag taagctgaga ttgcaagcta tagtaatctt tatagctata gtaatagcta 13500 ctttcatttt gaaaagtaaa aaattagacc aattgtcgta agaggctttc tgtttatagt 13560 gtacattttg gtatttacca cttagtttaa cttctgaggt gtcagctaag aatgcaagat 13620 ttaacaaaag tactacttac aaatggcagt ggtatgcctt tgttttttct ctctcacctc 13680 tccttctcaa aggtggtaac ccctaagtgt tcagatcata aacgagtgtt ctctttatga 13740 aatagttact aggttagatt cgtaaactgg tctagaaatc cagccacagt tcaagttttc 13800 tgggttgttt aaagtttcaa ctttaaagtt tattaaacaa cttacttcca aattaaagct 13860 gctgtataat ggtttttttt tttttttttt tttttgagat ggagtctcgc tctgttgccc 13920 aggctggagt gcaggggcgc tatctcggct cactgcaagc tccacctccc gggttctcac 13980 ctttctcctg cctcagcctc ctgagtagct gggactacag gtccccgcca ccacgcccga 14040 ctaatttttt tttgtatttt tagtagagac agggtttcac cttgttagcc aggatggtct 14100 cgatctcccg acctcgtgat ctgcccgcct cagcctccca aagtgctggg attacaggcg 14160 tgagccactg cacccggccc cgtataatgg tttttaaggt cactaatcat accatatgtt 14220 tgattcagaa taatttattt ccaggttcta ctgggctatt acaagttaat tacaatgtat 14280 ttgaacgaga tgagtgtttc tcaaacttaa gcatgcatca gaatcaccca gaagactcaa 14340 taccaactac aaattgctgg gttcccccag ccaccactga gtttctgatt cagtaggtct 14400 ggggtagtgc ctgagaattt gtgtttctaa caaggtgcca gttgatgctg atgttgctgg 14460 tttggggcct acagttttaa aaatcactga cgtaaaccaa catagggtct ctgctctgca 14520 gagatctgat tatatataat agtgaaacaa agtccttccc agctcagatt ccatggtgat 14580 aaagttcttt gtatacctca atagctgaga gatcaggaaa tcctatattt tactgataag 14640 ggaaaaacta gtgcctttta attaagtttt tattgtcatc ctgcagtttt cttaataagt 14700 tttggtattt cctcttatga gtgctgtttc ttagaaactt tgatcagact taggatcctg 14760 Página 46 ctttcctgaa gcttaggcaa ggacagggga taggatattt ataatagtag tgtagaaaat 14820 gttaacagcc atggaagaac atgtgtaatg ctatgatgaa actttctttt tttattgtgg 14880 ttagaaaaat gttatatgga tgacctgtag tttcttttga tctcactctt ggtcaggctg 14940 gagtgtgata gcgtgatcac acgttgaggc tactcactgc agcctcaccc tccccagact 15000 cagtgatcct cctacctgca cctcctggga ctgcaggtgc gcgccaccag gcccggctac 15060 tttttgtatt ttttgcagag acagggtttt gccatgttgc ctgggctggt cttgaactcc 15120 tactcttgag ctcagatggt ttcctcacct tggcctgtca aagtgctaaa gtgctaggat 15180 tacaggtgtg agccactgtg ctcggccaag acctgtagtt tctgtacctt tttaatttat 15240 ttttatttat ttatttattt attttttttg agacagattc tcactctgtc acccaggctg 15300 gagtgcagtg gcacgatctt ggctctctgc aacctctgcc acctgggttc aagcagttct 15360 cctgcctcag cttcccgagt agctgggatt acaggtggcc gcctccatac ccggctcatt 15420 tttgtatttt tagtagagac ggggtttcac cgtattggcc aggctggtct cgaactcctg 15480 accttgtgat ccgcctgcct cagcctcccg aagtgctgga attacaggcg tgagccactg 15540 tgcctggcca ccttttttat ttatttattt ttttgagacg gagtctcact ctgttgtcca 15600 ggctggagtg cagtggcagt ggcatgatct tggctcactg caacctccac ctcctgcctc 15660 agcctcccga gtagctggga ctacaagcat atgccaccat gcctggctaa tttttgtatt 15720 tttttttttt cagtagagtt agggtttcac catgttggcc aggctggtct ccagctcttg 15780 accttgtgat ccacccgcct cagcctcccg aagtgctagc attacaggcg tgagccatca 15840 cacccagcat tttttttttt tttttttaag acagtcttac tctgtttccc gggctggaat 15900 gcagtgacac aatctcgact cagtgtagtc tccacctcct gggttcaagt gattctcgtg 15960 cctcagcctc ctgagtagct gggattacag gttcatgcca ccacgcccag ctaatttttg 16020 tatttttagt agagacgaga ttttgtcatg ttgaccaaga tggtcttgaa ctcctgacct 16080 caagtgatct gcctgccttg gcctcccaaa gtgttgggat tacaggtgtg agccatggcg 16140 tcgggacctg tacctttgat ttactacatt tttttgactg ggcaattcag ttcgctgggt 16200 ataaggaact gtggtctgct ctttgaaaat tctgtaaaag agtcttgaga ttgttgagtt 16260 atgatttaca tacttatttc cttacagtaa actcatcagt tcttcacctt ttaaaaatct 16320 cagttattgg attgaaacat gagaaatatg ttaatagtaa tactaaatca gaataaatag 16380 gcatgtgagc tttaataaaa tgcacagttg tttttttttt ttaattttta ttttattggc 16440 caagatactg tgctgtcacc caggctggag agcagtcgtg cacatcacga cttccgactt 16500 gtggtctcgt gatcatcctg tctcagcctc ccaagtagct aggaccatag gcactaagtt 16560 aaaaaatttc cacgcctcgg taatttttaa attttttgta gagacaggtt ctcactatgt 16620 tgtccaggct ggtcttgaac tcctggcctc aagtgatcct tctgccttgg cctcccaaag 16680 tgctgggatt gcaggcctga gcaaccatgc ctggccataa tgtgtagatc tttattttgg 16740 ctatgcagag ttctttttgc atactttctt ttgtcataat gttccatgaa gatgtgtacc 16800 atgaagctga gtttcacata ctggctgttt cccttttcat ttccccttta accttgttcc 16860 Página 47 agttattgcc gtgtaacaga ttaatccaaa atttaaggga ttaaaaccat gattttctta 16920 tgcacaaaga ttctgcctgt cagggattca gacagggcac acaggagttt tgatgtttct 16980 gttcgatgac actgggggcc tcgtgggaag actaagactt gttcattcat atgtttgttg 17040 cttggactaa aatgagtgga accacaggga ttgctgatca gaagcaagag gcctttcttc 17100 atggcatggc ttcctcatca tgtggcagtc tcagagttac tgtatttgta tgatggctga 17160 aggctccaaa tacaaggtgt ttggatcacc agcaaacaag gcagagatag attgctttta 17220 tgactcagcc ttggaaatca tacagcatca cttatacagt actcttggtt gaagctcact 17280 caagtacaat ggcaggggaa gtagactagt tgttaatgga gtagtgccaa ggtcacattt 17340 tagaacagta tgtgagactg catgcagatt ttgtagctat ctttggaaaa tgtaatctgc 17400 gatagctctc ggtttggatg aattctaaat ttgttattgt gtagaaaatt ggaggttttc 17460 tactctagga tagcttgtcc tactatagga tagtataggt tcataattaa ggattgttat 17520 tggtgagagt cctaacaatg tactgaagtc tgtcaatttt agtatctttt ctgttgcgtg 17580 gaattcttat tgttttcatt aaacaaacta tatgttcatt gcacagtagt taagtgtata 17640 aaacaaagca aaaggaacac agctctggct ataattttac cactcaggta ccattcttac 17700 ctttttcatt gtttatcttt ttatatttat tttcatcgct acacaaacat tttttaggag 17760 tttgattcta cctccatttt ggttagatat acaaactcta ccccatgagg gatgtatggt 17820 gtatttctag atttagcaac aattttcttg aaaaatgtac aatactatag aaaaatgaag 17880 atagtaaata ccaggtataa gttaataaca gtgtttcttt tgttcagtaa taatgaactg 17940 tgtactagca ctgaacttta ggccctccta tttgcgtatt ttctgtttgt atatttttaa 18000 atagaggaat tgtgattata atattattat tttggaatat cctaaatcat aaattcaaaa 18060 cttatttagt tttttttttt tttttttaag atggagtctc gctttgtccc aggctggagt 18120 gcagtggcat gatctcagct ctctgcaacc tctgcctccc gggttcaagc gattctcctg 18180 cctcagcctt ctgagtagct gggattacaa gtgcgcgcca ccatgcctgg ctaatttttg 18240 tatttttggt agagacgggg tttcacagtg ttggccaggc tggtcttgaa ctcatgacct 18300 tgttatctgc cgacgttggc ctcccaaaat gctgggatta caggtgtgag ccaccgggcc 18360 tggtctagtt ttttatttct taaaaatagc ctacccttta agcaaataga attttttatt 18420 ttaaaaattt ttagcttccc aagcttatga gtcttccctt ttcttccctt ttaaaaaaga 18480 gaatgaacta tctgttgatc ctcagagtat tttgtgaggt aattggacac atcttctgca 18540 cctggggtca ggtctgtcat atcagtgtaa aaaaaaattt ttttccctca aatcagtaga 18600 ctgaaatttt atacctgttt atttggaggc ttatagatgg tgtgaaatag ttcatctaat 18660 aataaaattg ggtactatta aaagccttta atgtcttagt gattatcttg gttttattta 18720 cctccagtgt taggaaggaa ttgtggtagg gttttcaatt tggggtagaa tggctaggca 18780 agttgacatt tgtttatggt acaaagaaaa tagatcattt gacctaaaaa aaaaaaaaaa 18840 aaagaaaaaa caaaacttat taccattgct tttaaactgg cttctgtggt ttctgaatgc 18900 cctttattag aatttaactt tgtactttgt ttcacaattt tattattggt aagggggtaa 18960 Página 48 ggaactatgt atgttcataa tttattggga ttaagtgttg tcctgttaat ttagatttat 19020 cctcattcac tgtcctcttg acctttacaa taataatagt ttgtgactct gttgcattac 19080 ctgaatatct gtggggtctt acttaatagt agcctgggaa acctgcaaag ttttaatctt 19140 agcaagaaaa tgggatctta aaccagatgt tagttttctg tcctcaccct tgaactaaca 19200 aagcaaagct gttgacttgt gtattagtga ggtggtagct atcttgttca agataaatgg 19260 atgaagtaca ttaaagacaa tatgcccatg agtttattca gaaaaaaaat actttttttc 19320 cccttggggt ggggagcagc atctcacgct gtcgcctagg ctggagtttt ggcattattt 19380 cagctaactg cagccttcac ctccagggtt caagtgattc tcccacctca acctcccaag 19440 tacctgggac tacagtctcg taccaccata cccagctaat ttttgtgttt tttggtagag 19500 atggggtttc atcatgttgg ccaggctggt cttaatctcc tgacctcaaa tgatccaccc 19560 accttggcct tccagaatgc tgggattaca ggcaggagcc accgtgcctg gcccgaaaaa 19620 atactctttt ttttttggat gcaaaatttc actcttgttg cccaggctgg agtgcaatgg 19680 tgcgatctcg gctcaccgca gcctctgcct cttgggttca agtgattctc ccgcctcagc 19740 ctcctgagta gctgggatta caggcatgca ccaccatgcc cagctgattt tgtattttta 19800 gtagagacga ggtttctcca tgttggtcag gctggtctcg agctcctgac ctcaggtgat 19860 ccgcccacct tggcctccca aagtgctggg attacaggtg tgagccaccg tgttcagcct 19920 aaaaatactc ttatatcacc tagtcacatg aattctttgg ggagagggag aggcaaaaat 19980 ttaacttgat aaatgtctga tatgctcact tgggtataag caggatccta accaaattgt 20040 ggcccttacc catgtgggta ggagccatat gcctagtcca tctaatactc tttcttgatt 20100 aagctaaaga atgaataatg ttgtgccatt ggtttacagt acagcctttg atatcattca 20160 gcaatggttg gagtatatct aaaaagtttt atgtacttag gctgggcgcg gtggctcatg 20220 cctgtaatcc taacacttgg ggaggccgag gcaggtggat cacctgaggt caggagtttg 20280 agatcagcct ggccacatgg tgaaaccctg tctctacaaa aaatacaaaa aaattagctg 20340 ggcgtggtgg tgagtgcctg taatcccagc tactttaggg gctgatgcag tagaatagct 20400 tgaacgtggg aggcagaggt tgcattgaga caagatcgtg ccattgcacg ctagcctggg 20460 tgacgagcga aactctgtct caaaaaaaaa aaatttatgt acttaaactg gaatatatct 20520 taaaagttta tttaagtcaa aatttgagac aaacttagag gattgtgagg gttttgtcaa 20580 gcatgcttaa gctggtatat accttcaaaa cggaatgtaa ttcttttttt tcttttaaca 20640 tagggtaagc ttgatgatta ccaggaacga atgaacaaag gggaaaggct taatcaagat 20700 cagctggtaa agatgttata ttttttattt tagacctaat gctcactatt ttaaagacaa 20760 aaattaattc tgtggttttt tgtctttcca gtaaagtttg ggttctttgt cattttagga 20820 tgccgtttct aagtaccagg aagtcacaaa taatttggag tttgcaaaag aattacagag 20880 gagtttcatg gcactaagtc aagatgtaag taaaagaaag tatacatatt tatgaaatac 20940 ttttgttgtt tctttgggtt ttagtccttc cattactatt gataagctct ctgcaaggtg 21000 agacagttgt atccaattat atctaagatg ccttcacatt ctgtaaagta aaatgtaaca 21060 Página 49 cctgaaagat gtcttttaaa aatactaagt ttgaaattgg gggcggtggc atgtgcttgt 21120 agccctggct cctcaatagg ttgaggccaa gagttcatgg ctgtggtgca tatgattgtt 21180 cctgtgaata gccaccgcac ttcagcctgg gcaacgtgat aaaaccccat ctctaaaaaa 21240 aaaaaaaaac attaaattta aaaatttttt taaaaggacc aagtttgaga tttgacaacc 21300 atgtatagta gctatgctaa aggtctcatt ggtttaaaat gttagctctg caaatacata 21360 aaaatcagat agtcattaga aatacataaa tgttttttat ttatcatgtt ccttatgtct 21420 aatgactcac aatttaaact gtcagaaaat aaagaggctc gtttatataa ttggtaatta 21480 ttctctgctt taggaacctt aaggggtatg gcaaactgat gtgctcctat atcagcactc 21540 gatccaactt aatagtgggt ttttgatgtg acaaaaacct ttgggaataa ggacaaaagt 21600 taaatgcaag caaagtcaga taatttgttg aggccagaaa attaagccat ctgaataagt 21660 gtcatcttct ttggagaaga ctaataacat tgaaatacag gcatgtactc cataatgatg 21720 tttcagtcaa ctttggacca catatatgat gatggtccca taacattgta atactgtatt 21780 tttactgtac ctattctgtg tttcgatata taaatacctc tgtgttacag ttgcctacag 21840 tagtcagtac agtaacatgc tgtacacatt tgtagtctag gagctaatat gctataccac 21900 atagcctagg tgtgtagtag attgtactat ctaggccgtg taagtacact ccatgtttgc 21960 acaatgagga aattccctac tgacatattt ctcagaatgt atccttgtta agtaatgtgt 22020 gactatgtaa agttgcctct aatttgctga aacaaaaaag tttattatat gagacaatgc 22080 agtgtaggga ttaagagatc agattctaga aacagactgc ccagttgaat cctaattttg 22140 tgacttgact ttgtagtttg accatggatg agttacttaa tttcactgtt cttgtattag 22200 tcaaggtttt ccagagaaac agatccaata ggatagaaag ggggctgatg ggcagaggcc 22260 atcacagtgc ctcggttttc taatctgtaa agtggtaata ataacctcat acggttgtgc 22320 ttagaacagt atttgatgca taactaatat atttcaagca cttaatcatt tttgtttgtt 22380 tgtcttgttt tgagacagag tcttgctctg tcgcccaggc tggagtgcag tgccgctgtc 22440 tcagctcact gcaacctccg cctcctgagt aactgggact acagacctgc gccaccatgc 22500 cagtctaatt ttctaatttt tagtagggat ggggtttcac catgtcagcc aggcttgtct 22560 caaactcctg acccctcaga tgatcggcct gcctcagcct cccaaagtgt tgggattaca 22620 gtgtgagcca acgtgcctag cttcaattac ttaatcttag aattacttat tacatctgat 22680 cagggaagga aaatctttgc tgaaaacaaa aaaagtaatt taattttgta cctagtgtct 22740 tagtcaactt tgtgttacta taatggaatg cctgagaccg gataatttat ataaagaaca 22800 gaaatttgtt tctcacactt ctggatgctg ggaagtccaa gatcaaggta ccagcatctt 22860 gttgcattac tgtgtcctca cctggtggta gaaggcttaa gggcaagaga gagtgatcat 22920 actcctgcaa gctcttttta tagtagtatt aattcattct aaatagctcc caaaaggccc 22980 accctcccaa cactattgcg ttgggagggt taagtttcta acacttgaat tttaggggga 23040 tgcattcaga ccatagcacc aaaggagaga tttattccac ttagcttaat gaaccctgcc 23100 caatttcttt ttcttgcttt tttaaaatag aagcaggatt gctatacagt ttaatgtaac 23160 Página 50 atctattttg gaagttacta tcactgtgta atgaaaatac ctgtatcctt ttttgcttct 23220 cttgtaacac tggtattttc aggacctttc tctgagcttt aacttcatta gcagagctgt 23280 tatttatctt tgatcctttg gtatactgta cacaattatt aaacatgctt tttgtttagc 23340 attcaagaac ttctttagcc tggctccagc ctaccttttc acctttttcc ttcttgaact 23400 gttcatttca tacagaatag ctttctttct tatcttcttt tgctttgtta acttcctttc 23460 atattcctgt ccctcttcct gtgtttcctg cctccaccta cctataaaga ccttcctggg 23520 cagggtgtgg ttgctcacgc ctgtaacccc agcactttgg aaggccgagg tgggtggatc 23580 acctgaggtc agaagttcga gaccagcctg gccaacatag tgaaaccctg tctctgctaa 23640 aaatacaaaa attagccggg cttggcagca cacacctgta atcccaggag gctgaggcag 23700 cagaattact tgaattcgag aagtagaggt gtcagtgagc caagatcgtg ccactgcact 23760 cctgggcaac agagtgagac tccatctcaa aaaacaaaca aaaaacacct tcctggctgg 23820 tcatggtggc tcatacctgt aatcctagta ttttaaggag gctgaggtga gaggatcgct 23880 tgaggccagg agttcaagac ccaagaccag ccttggaaac atagaccttg cctcaaaaaa 23940 ctttttttaa attatttttt taaaaaagac tttttttttt ttcttgagac agtctcactg 24000 tttcacccag gctggagtgc agtagcatga tctcagctca ctgtagctat cacttgccat 24060 ttattgctaa gatatttatt ctgcacactc tgttaccatt atagatttgt cttgttcttg 24120 cagccttcat cattcttccc aggtctcctt ccccattttt ccctttagta taggtttcat 24180 atgtccctat tttggttttc tgtgtcttgg ttcatcctag tgaggcttga gaagggggaa 24240 aaggtggaaa ggaaagcact accatggctt ttgagaagac tagccttcct ctattcccaa 24300 cctcatgtta gatacacggg agagggagag gaataattga gtttggctga tgctttcctt 24360 tcagcctttc caggaaagaa aaaaaggaat gtgggaaaaa tacattcata cttagcttta 24420 tctatttttc tccaccagca tcatcttatt cataaaaaca aattaggcac tcttttcagt 24480 aagatggaat aactttctga gactggcagc ggattatttg ggacaaaggg gcccttgtgg 24540 gtttttggca tttccttgtg agtcattagt agatactcaa agttagaact ttgggtcatt 24600 tgcccataga ggagctagat tgaggtaaga tttttattgt tgctgtggtt gggtttcttt 24660 tttaattggc ctaggccttt acatttctgt ataatttcta aattcattaa atttttactt 24720 tttatatgca taatgaaaaa cttcagatat atatacctaa ctaaagaaaa caatacaatg 24780 aaactctttg tacctgtacc cagcttgtat atttatcatc tcatggtcaa tcgtatttca 24840 tataaatcca cattcatttc cttgctccct ttgccctcta gattattttc aaacaagccc 24900 caaacacatt gtttcatcag taatagttca gtagtaaaat accttctagg gaaagagctg 24960 ttctgaattt ttaacaattg cttaaaatag attatgttta aaactatttg taagtcagga 25020 atcatccttt tgtgtattga ggtcatatct cactcattga gtaaaacatg ttttatttaa 25080 gctggacctg aaatggattg aactaagttt tatataacta attttggtgt tttactttta 25140 tattgttttg cagattcaga aaacaataaa gaagacagca cgtcgggagc agcttatgag 25200 agaagaagct gaacagaaac gtttaaaaac tgtacttgag ctacagtatg ttttggacaa 25260 Página 51 attgggagat gatgaagtgc ggactgacct gaaacaaggt ttgaatggag tgccaatatt 25320 gtccgaagag gagttgtcat tgttggatga attctataag ctagtagacc ctgaacggga 25380 catgagcttg aggtattagt ggtatttgat aatagaaact tctgagtatt taagttgaca 25440 actgaaaggt tattaattag ctatttacta ttaaaaggtt gaatgaacag tatgaacatg 25500 cctccattca cctgtgggac ctgctggaag ggaaggaaaa acctgtatgt ggaaccacct 25560 gtgagtatca ctgtgataac tttgatttta taactaggaa tctttaaaaa ctaattttct 25620 tatgtttata gttcacttgg aagaaaaaaa ttagtttttt tttttttttg gagacagagt 25680 ctactctgtt gcccaggttg gagtgtagta gtgtgatctc agctcacagc aacctccgcc 25740 tcccaggttt aagtgatttc tatcacctca tcctcccaag tagctgggat tacaggcatg 25800 cgccaccacg cctggctatt ttttgtattt ttagtagaga cagggtttcg ccatgtaggc 25860 caggctggtc tcgaactcct taccacaaat gattcacctg cctgggcctc ccagagtgct 25920 gggattacag gtgtgagcca ctgcgcccag ctagttttcc tatttaaaat taatattaat 25980 tgaataaaat ttagaaatgt atacatagca ttcatctgct atttactgtt tggtttattt 26040 cttttttgtt tctttgtatg tttaatctgt aatgtggaaa tcagaacacc agcaacaaac 26100 aactaaaact gggaatatga tagtcctaac ttcacatggt cttgtatgta acttaactgt 26160 gtttgaggtg gacagattaa cattagattg actttccaca gcttttggta atagataggg 26220 actgtttgtt ttatggctga agttttgtga aacaattatt gcatttcata cattctgctc 26280 atggttattg ccttagtttt tctttagttt gtcttagaca tctgctaatt tgaggatgtt 26340 aatttttttc tgtatttaaa atatgctgat acttggtcta gttttctttg tgagctcctt 26400 attctcaaac atgcaactgt gaactgattt ttttaaaaag ggacatttac gtttcactcc 26460 ttcagtatag gaatttacgt ttttagcctt ctgtgaaatc agggaataga ttcttatctt 26520 tgccatttat aaggttgcat taggaaggta gatttttgaa cataaaatga aagtatctgt 26580 atttatgcat ttttagctat tggttgaaaa gaaatcagat tggattataa gctttaatca 26640 ccaaaatggt atgagcttta attggcaaaa tttagaagag tatatttgct ttaaggaaat 26700 gggtgccagt ccttgtctgt cctttcttca tttaagaaat aattttcttg gtttgttaac 26760 atttactctg gtctgtattt ctttgtacaa tatgtgttta cccttttgct tttagttctg 26820 caagttctat atgtataagc ttgttaactt aaaaaagtag ttttaggtca agcttcatca 26880 gattttcatg agcattgttg aagagtaaca aaggtgttat taaaccttta agcttatagc 26940 ttgttttggg gttattttct acctaatctt gttcccacat cttaggaatg taacatcttt 27000 acaatggaaa ggtactaatc tttataatgg gaaggtacta atatacccaa attagtgttt 27060 ttatgtacat ttgatttgta tctataactt tttgaaaaca gttttgagcc aggagccgct 27120 gaagtgaaat aaggaaaaca tatgaagtgt tcattatcta aagagttgtt ggtagtttat 27180 taagattaat ttcccaatgc ttttgataca atatggtcct caaagtttta tttttcttca 27240 cagtgaccta tcggggagtg gccctactat gtatctatta ataatacaca agctaagaaa 27300 attgaaagta ataactcttc atacatctcc ccctctgccc tgcactttta aaaaataccc 27360 Página 52 tggtacacca aattctgata gtttttgttt gtttttgaat atctttcgat tgtctacttt 27420 tttctcttct acttttatac ctttctcttg tctgacgcag ttgcttaact gagtccaccc 27480 ctctccctct ttaaaatctt tagtggcttc atctcagttt tattttatat aagtttgtcc 27540 ttaacttcaa ggacattcat ggtctggcct ttaccagttt ctccagccac atctttccct 27600 atgcttgttt tttattccct gtattttagc cacagtggct tcctttcctt ttcttgtatt 27660 tgacatcttt tgtataggac tttgtaatgc tctttcttct cccttgaaac acttcttccc 27720 ctctactctt ctggatttca actcttgtag cacttaccta gggaaacctt ttgtggcctc 27780 actctgattg ggtccagtcc attgtagttc tgtgtagtac ttttcacaga tgtaagtttt 27840 ttgtagttgt atttgatacc acttctgtta gaccataagc ttattgaggg gatatattgt 27900 gtctttacat aactttttgt tttcccagtg cctagcatat tgtctaatgt gtagtaggtg 27960 ctgaataaat acttttgaat gaataaatgt taaatgtcat ctttttccac ctaactagtt 28020 tacttaaaat acataaagtt caggccgggc atggtggctc atgcctgtta atcccagccc 28080 tttgggaagc caaggtgggc atatcgcctg aggtcagacc ttcactaggc aacatggtaa 28140 aaccttgcct ctactgaaaa tacaaaaatt ggctggacgt ggtggtacac gcctgtaatc 28200 tcagctactt gggtggctga ggaacaagaa ttgcttgaat ctgggaggca gaggttgcag 28260 tgagctgaga taacgccact gcactccagc ctgggtttca gagcaagact gtatctcaaa 28320 aacaaacaaa caaaaacccc gtaaagttta atataactac attcttcttg ttccctatca 28380 ttctgtaata catttctgtt cttggtgaaa tgtaatcttt ttatgtgtat atgtgtttta 28440 gtaacagtta ttttttaatc acaatatttt atagaatgtt ggatcttctt caagccaggc 28500 atcctcagat aagtcttaca ttataattca tgttcttttt cttagataaa gttctaaagg 28560 aaattgttga gcgtgttttt cagtcaaact actttgacag cacccacaac caccagaatg 28620 ggctgtgtga ggaagaagag gcagcctcag cacctgcagt tgaagaccag gtacctgaag 28680 ctggtgagta ttaggtggat atcaacttta gtttagggtc ctggttttat ttgattttgc 28740 tacaaattta aactatacac ttacttagtt ttcatatatg tacactagat tttattttta 28800 aagagacttt aagcatgaca aagttttttt tttttttttt tttttttttt ttttttttgg 28860 agacagagtc tcgctctgtt gcccaggctg gagtgcagtg gcgtgatctc ggctcactgc 28920 aagctccgcc tcctgggttc acgccattct cctgcctcag cctcctgagc agctgtgact 28980 acaggcgccc gccaccacgc ccggctattt ttttgaattt ttagtaaaga cggggtttca 29040 ctgtgttggc caggatggtc tcgatccctt gacctcgtga tccacccgcc tcggcctccc 29100 aaagtgctga gattacaggc gtgagccact gcgcccggcc ttgacaaaat gttaagacag 29160 attatcaaga gtaattccta ccagtattca ttatatttgt cttagtagtc atttgtctta 29220 ctagtcttga tcactattat aaactgatag atagttcttt tgcagtagta ttgatgggca 29280 ggagtatggg tgagggccag ctgttacaag gattttcaaa taggtttctg tctgacatgc 29340 ccagatttgc tatttactat gccagtgcat tggaggaata gtatgagttg cttttgtttt 29400 gttttaatca tggggagatt atagctccat aatcttgaac tataaattcc tccaaggcaa 29460 Página 53 ggggtctttt ccagttaatt ttatcatgta gcacaacact aattatatag ctagacactt 29520 aactgtgaat acttttatga taactcttat gttgatgagt aaaattctga atacaaggaa 29580 acattggagc ataagttttg ttagaatcag agtgcctgaa tttaaatctt cgcttcaaca 29640 cttactagct ctgtaacttt gggcaagtta atgaaactct tgtacctcag gttccccgtt 29700 tagaaaatat gtcaagtgtg tatacagtgc ctgacacgtg gtaagcactt agtaactggt 29760 agctagtagg ttgaaactag aagtgaagat tgtacattgg tggagttaat agttggagat 29820 taatataagg caatcttttt ccccctctta ccactttact aagtaaagta agatttttaa 29880 tctgtatgct gcttcatact actacttatg agacgggaga gggcttttaa tatagtagct 29940 ctttatttgc attatacatt atctgaaata gctactgttg aacctaaagt aattctggaa 30000 taaatggtaa agaaaacttt ctaaaatata aaacactgtt aattaacttt ataaataagt 30060 ttgtaagtaa attcagatta tgtgatggca aactatttac ttatttggaa tttaagttga 30120 attctttttt ttttttttga gacagtctct gtttgtcact caggctggag tgcagtggtg 30180 tgatcctgac tcactgcaac ctctgcctcc cgggttcaag cgattatcct gtctcaggct 30240 cctgagtagt ggggactaca ggcgcatcac cacaccaggc taatttttgt attttcagta 30300 gagatggggt ttcaccatgt tggtcaggct ggtctcgaac tcctgacctc aggttatcca 30360 cccgccttgg cctcccaaag tgctgggatt acaggcatga gccactgtgc ccagcctttt 30420 tttttttttg agtcagagtc tagttctgtc gcccacgctg gagtgtagtc gcatgatctt 30480 ggctcactgc agtttccacc tccaagggtc aagcaattct cctgctttag cctctcgagt 30540 agctgggatt acaggtgcat ggcaccacac ctgactcagt tttttttgta tctttagtag 30600 agacagggtt tcaccatatc ggctaggctg gtctcaaact cctgacctca agtgatctgc 30660 ccacattggc ctcccaaagt cctgagatta taggcgtgag ccaccatgcc cggccttaag 30720 ttgaattctt ttttgtgggg gacagggggc actgagtctc actctgtcac ccaggctgga 30780 gtgcagtggc gcgatctcag cttgctgcaa cctctgcctc ccgggttcaa gcgattctca 30840 tgcctcagcc ttcccagtag ctggtattac aggcacacac caccatgtct ggctaatttt 30900 tgtattttta gtagagacgg ggtttcacca tgttggccag gctggtctca agctcctgac 30960 ctcaggtgat cccccaacct cggcctccca gagtgctggg attacaggcg tgagccagcg 31020 cgcctggcct agttgaattc ttaactttaa aaaagattta ttacacttta tggcatcatt 31080 tctaaaaata gactttattt ttatttttta tttttatttt ttgagatgga gttttgctct 31140 tgtttcccag gttggagcac aatggcctga tctcggctca ctgcaacctc catctcccag 31200 gttcaagcga ttctcctgcc tcagcctcct gagtagctgg gattgcaggc gtccgccacc 31260 atgcccggct aattttttgc atttttagta gagttggggt ttcaccaggt tggctaggtt 31320 ggtctcgaac tcctgacctg aggtgatcca cctgtcttgg ccttccaaag tgctgggatt 31380 acagacatga gccactgtgc ctggccgact ttatttttta gagcagtttt aggctcacag 31440 caaaactgaa cagaaggtgt agagatttcc catttacttt ctaccctcac agatgcacag 31500 cctccctcat tgtcagcatc cccccaacca gagtggtaca tttgttaaca atggataaac 31560 Página 54 ccaaactgac acattattat cacccaaagt ccatagttta catatgggtt tactcttatt 31620 gttaataatt ctctgggttt ggacaaatgc ataatgacgt gtatctacca atatcacaca 31680 gagtagagta gtatcactga cctaaaaatc cttttgtttt gcaccatttt ttaacctctt 31740 agaacctgag ccagcagaag agtacactga gcaaagtgaa gttgaatcaa cagaggtatg 31800 attttaattt aatgctgcct ttactttgct gcctttcaaa caaatgtctc aaacatttac 31860 tttgctttgc agtatgtaaa tagacagttc atggcagaaa cacagttcac cagtggtgaa 31920 aaggagcagg tagatgagtg gacagttgaa acggttgagg taagagttct ctgtattgca 31980 aagttgttgt ctttgtcttc agttagtaat ttttatctct actgagaaca aattaagatt 32040 gttttttgca ttattagtac atttattata ataacagact cattacacca gactgttact 32100 tccaaaaaat gaatgtttat ccctgtggat gtttaatagg atccctgctt tgctgaacca 32160 atctaaaaaa attattttat acaaagttat ctgtggatta atctgttacc atgatttgtc 32220 tcttactgaa attaggttgc tctgtaaaaa tctgggctcc cacactgata gctgtgtttt 32280 ggggtatcat cttgcactcc tcctttaccc taatgctgtt tggtcaccag gctgtagact 32340 tcctctagcg ttttctaatg ctgtctctca actgataatg atgatttttt tcgggtcctc 32400 atgtctagtt cagtgactct cttcatatta ctcctctctg actgcctcca gaccatccta 32460 ttcattgtca caacttaatt attggaaaag ttagctttaa gttacttgta cttgaggctc 32520 tcagtgatgc cttgttacct gtaagataca gtctaaaaac cttaccaact ggtcctggcc 32580 ttccttttga tcttctttta gatgtctttc tttacacccc caaggtgcag gaaaatagct 32640 gtaagctgag ggtaatatgc ttttcctttt aatatgttat tcttatatca agaccattct 32700 cttggccggg cacggtggtt catgcctgta accccagcac tttgtggggc tgaggcaggt 32760 ggatcacatg aggccaagag ttagagacca gcctggccag catggtgaaa cccagtctct 32820 acttcaaaaa caaacaaaaa cctgggcatg gtggtgcatg cctgtaatcc cagctacttg 32880 ggaggctgag gtacgagaat cacttgaact ggggagacag aagttgtagt gagctgagat 32940 cgtgccactg cattccaacc tggttgacag agactctgtc tcaagaagaa aaaaacccat 33000 tttccaaaga gattgcaaag tttttttttt ttgagagtct cactcttgcc cagtagagat 33060 ggggtttcac cattttggcc aggctcgtct tgaattcctg acctcaagtg atctgcccgt 33120 ttcagcctcc caaagtgctg ggattacagt catgagccac tgcgcctggc ccatagatgt 33180 tataattgtg ccagcaactt catccctctg ttggagcacc aaaatgtccc attggtaagg 33240 taaagagagt aggcacttac cccagaaagg tacttgggat gaaaatactg ctcaggaagt 33300 cccaacaaaa tagtgtatat ttgctgaatt aaagaatgca gttcagaaat gttataggag 33360 gattagaaga gaaatcaatc aaaaagatta gtagaggtga tttacagttg ttccttgtta 33420 taccaggggc attggtttta ggacactccc acacaccgaa gtctgctcat actcaagttg 33480 tgccatgtat ctgcgggacc cacatatata caggtgtttc acatctcaag agtactggag 33540 gataagtgaa cctgtgcagt tcaagcccat gttgttcaaa tgtcagctgt atatatgagg 33600 tgtacaaacc cattgagcct tgactaagtc gatgggatgt atgtttttag gggagccagg 33660 Página 55 taatagggat gtatagcatg gatgtagaag tagaaatgaa ctattaacat atttgtttta 33720 ttgaacatag aatgcaaggt aaatattgac atagtaggaa gaagttggga agcagtatac 33780 agtgctttgt agttaagtat tttttggatt ttatttgaga agagcatact acttgccact 33840 gtgccagtgt ggtttgttct ttgtatctag taggtgggcc tttctaaagg ctatccacat 33900 gagattccac gaatttttgg agcatcctga agttggtatt acacagattg ttggtttcgc 33960 tttggtagtg atttttatct gtgttgttta taaagggaat agctgatttt gcctagtttc 34020 aaccagtatg acttgtccag ttttaaatcc agacagaata atataaattt gatgtaataa 34080 aagataggat ttccttgcag agcagggaat tactaagaac aataagcaga ggaaattatt 34140 agagctggga aaaggctaat agagtgagct ttggcttctg tagcagttta gatgagttgg 34200 taaagcttga tcctatggtg ttggctgaga aaatggaatg ggaaaaaccc aaatcttgat 34260 gataataata gctaacattt cttgagtgct atgtaccagg ttgtgagata gatatatatt 34320 tgacatagat atataaatcc agttactata gaaggcataa cagttttaag aaaaatacat 34380 tattttagga tgtaaacaca ggtaatcttt ctttgaaagc agcttataaa ataaatctga 34440 ggctgggcat ggtggctcat gcctgtattc ccagcacttg ggatgccaag gcgggtgggt 34500 cacaaggtca ggagttcaag accagcctgg ccaatatggt gtgaaaccct gtctccgcta 34560 aaaatacaaa aattagccgg gtgtgttgat gggtgcctgt aatcccagct acctgagagg 34620 ctgaggcagg agaattgctt gaacccggga gatggatgtt gcagtgagtc gagatcccgc 34680 cactgctgtc cagcctgggt tacagagcta gattccgtct cgaaagaaaa aaaaataaat 34740 aaataagtaa atcaacatga aatgctacat agtggtctta tggaactgaa acactgtaga 34800 agtgatgaca tttttcagaa tgttaaattt ggcataaatg taattcattt gggtaactgc 34860 attaaagccc gttctgttta tagtatagat ggtttatgta gtgtggggga cccatcatgg 34920 tggtagtgag tggagctttt ttgctctcct attccttcta atcctttttt ttctacctta 34980 ggtggtaaat tcactccagc agcaacctca ggctgcatcc ccttcagtac cagagcccca 35040 ctctttgact ccagtggctc aggcagatcc ccttgtgaga agacagcgag tacaagacct 35100 tatggcacaa atgcagggtc cctataattt catacaggta tgttcatttt agtcagactc 35160 tgtaacagaa agtttaagtg tttatattat ttgactttat tctatcctaa cttaacctgt 35220 aggattcaat gctggatttt gaaaatcaga cacttgatcc tgccattgta tctgcacagc 35280 ctatgaatcc aacacaaaac atggacatgc cccagctggt ttgccctcca ggttagtagt 35340 ggtacatttt tatgtgagag agaaatataa ggccagtact ttcaggtttt aaaaagattg 35400 tgaaaataaa ttttgtttat tttaatgact gtttaatttt gactcttagg tcttttaatt 35460 tgatagaaag aatgttattg ttcctatgat ttgaattaaa aatgtagttt ataactgttt 35520 atttttaaac ttttcattgg catgtagata tagaaaaata tacgcaagtt taatgagttt 35580 ttataaactg aaaacacctg cagctagatt aagaaatgaa acattaccag taccccagaa 35640 acctacgttg tttcctttca atcactagtt accctcaccc ctagcgatag caaccacttc 35700 cgtacttgta actgtaatag accagttttg tctgtttttg taactttaac aagtgaaatt 35760 Página 56 ttgcttggct tttaaaattt caaaattaat ctaggagtaa aaataataga ggtgcctttt 35820 tttgaatgct tttagctttc taggagaatt tctggatttt attaccttaa aaaaatacac 35880 agcaatgaag tgggtaaggg aatatgtaag aggcaaaggg aagagagaaa ccacaagaca 35940 gtttcagact ctttctggac ttacaccatt atttgaagta gtagcactaa atacagttgg 36000 tgccttccat tgggttaagt ggaccttctc tccaggacta ttagtgattg tgagtcatct 36060 tggtttttcc cagaacacat cagttttagt tgcacaaaag tggaactaaa taaaataacc 36120 tatttaatgt tgcatgatgt taaatatcat aaaataaatt gctgagtaaa agtatgttta 36180 atgacagtta atttggtgta aggtagttag gatttttctg aagtaaaggg agctcatatc 36240 tctcacattt tttttttttt tttttttttg agacggagtc tcgctctgtc gcccaggctg 36300 gagtgcagtg gcgcaatctc ggctcactgc aagctccgcc tcccgggttc acgccattct 36360 cctgcctcag cctcccaagt agctgggact acaggcgccc gccactacac ccggctaatt 36420 ttttgtattt ttagtagaga cggggtttca ctgttttagc cgggatggtc tcgatctcct 36480 gacctcgtga tccgcccgcc tcggcctccc aaagtgctgg gattacaggc gtgagccacc 36540 gcgcccggct ctcacatttc tatcaagagt tttagaaaac agatcaaagg tgacacctac 36600 aagagagcaa tcatggtttt tagtgttcat tttctgagct ctaccaaagg aagagagtaa 36660 gtcgttttct cagctgggga gttgtgtgaa agtcagtata catagcactg ataaaacctg 36720 taaggctatt tagttattta cataatgctg agtccattag actctccagt gaaaatgggt 36780 actttctaaa tgactaacca aagatcgtcg ttttgattat ctgtttaatc attgttggga 36840 agggaggtga gagagtgatg ggaattgtta agaagatgca tgctgagttg aatataggct 36900 gttaaaaagt atatattatt tatttgttta tttagagacg cagtctcgct ctatcgccag 36960 gctggagtgc agtggcgcat tcttggctcg gcacgctgca acccctgcct cccgggttca 37020 agggattctc ctgcctcagc ctccccagta gctgaaagta caggcacaca ccacactaca 37080 cccagctaat ttttgtattt taagtagaga tggggtttca ccatgttggc caggatggtg 37140 tcaatctctt gacctcgtga tccacccgcc tcggcctccc aaagtgctgg gattacaagc 37200 atgagccact gtgcctggcc gaaaagtaca tattttaaat tttctttttc tctagaaaca 37260 cttgaaattg aaagttggtt atgttaacat atattgagcc gggtatggta gctcatgcct 37320 gtaatctcag tgctttggga ggctgaggag ggaggatcac ttgagcccag gagtttgaga 37380 ccagcctgag caacatagac ctcgcctcta caaaaaaatt aaaaattagt caaataaaaa 37440 agttagcttg gcagggtggc atgcatctat agtcccagct actcaagaag ccaaggtggg 37500 aggatttctt gagcccagag tttgagacta cagttagcta tgatggcgcc actgcactcc 37560 agcctgggca acacagtgag accctgtttc agaagaaaca aaaggtcaaa atggaatact 37620 atctgtctga ggtctagagt atgaataatg ccactttatt gtacagcttt aaaagtcttt 37680 tttcatggca ctgattattt gttagtgcat tctattaaca ttttacttta cttttggaaa 37740 aaacaagatg aaaccaattg tgaaagtaaa ctattaaata ataaccactg ccggtaaacc 37800 aaaatgctca cttgaaagct aaaattttat ctgcatttcc caatttactt tcatgattgc 37860 Página 57 taaaaagttt atttatggtt tggctataga aatttacctt taattgctgg gcatggtggt 37920 tcattcctat aatcccagca ctttgggagg ctgaggtggg cagattgctt gagcctagga 37980 gtttgagacc agcctgggca acatggcgaa accctgtctc tactaaaaat acaaatatta 38040 tccgagtgtg gtggcacaca cctgtagtca cagctacttg ggaggctgag gtgggaggat 38100 cacttgagcc tgggaggcag aggttgcagt gagctaagat cacatcactg tactccagcc 38160 tgggtgacag agtgagacac tccccccccc cccccccccg caaaaaaaaa aaaaaaaaaa 38220 aaaagccttt aatagcgaaa taaaaggtat ttagacgcgt ctctctaaaa atttaatttt 38280 gtttgacaaa aatgttttgg tcacctttgc agttcattct gaatctagac ttgctcagcc 38340 taatcaagtt cctgtacaac cagaagcgac acaggtaaga gtgataaaac tattttcttc 38400 agggccaggt taggtggctc gtacctataa tcctagtact ttaggaggct gagatgggag 38460 gatcacttga ggtcaggagt tcaagaccag tctgggcagt gtagcgagac accatctcta 38520 ttttaaaaaa ataattaaaa aatatttttt cacttttgtt ttaattggtt ccttggtttc 38580 tttcttagct tatgaaagaa aataagaatt tcatcagtgt ccaagtcttc tgttggaatt 38640 cagcaaattt attgttgtgg atagctgtca gcctttattt ttatgtttag gttcattttt 38700 cctcttgatg actttttaag tttttcttaa gtcttgcatt ttaaataatg tattataata 38760 taataagcct tttttattta gaactgagaa tttcagaaga catagtttag acataattct 38820 aaaatttagt gcagatttct ccatcttaga agtacttgtg gagggctttt ataacgagac 38880 ttgggtttat ttaacgtcga gcttcaaaaa tatatatatt tttgcaattt ttaggtttta 38940 tattatacaa atttaaagag agatggtaat attaatttct cccttcttta gcagttgtat 39000 ctatttctta gccttatgcg tcttagaggt aacttgtttt tttaacagtc aattttgtaa 39060 gcaggaagaa gcttttattt ctttacttat gtctaggttc ctttggtatc atccacaagt 39120 gaggggtaca cagcatctca acccttgtac cagccttctc atgctacaga gcaacgacca 39180 cagaaggaac caattgatca gattcaggca agttctgtta ccgggtcaca tacatttgat 39240 gaggcactta ctcatgaatt gaacagatgt acattaccat taatataatg attcttcttt 39300 ttggacctac tttgctttca tgaaatattt gagtttgtta atacatataa gtttgagatt 39360 aatttaccac tttagtacat ctgttcactt tttgtttggc taagtttagt ttaccgctaa 39420 agtgcatcta ttcactttgt gtttaggcaa caatctcttt aaatacagac cagactacag 39480 catcatcatc ccttcctgct gcgtctcagc ctcaagtatt tcaggctggg acaagcaaac 39540 ctttacatag cagtggaatc aatgtaaatg cagctccatt ccaatccatg caaacggtaa 39600 gcaaattaac taacattaat tgcctagtat gtaatatgaa tcatggtaga ttttcttttc 39660 ttttttaaag gtcttcattt aactgtgctt gagtctgcat ctttcattaa ctgtagggta 39720 tatttaattg aacataaact gattattcca gagattaact gatactaacg gatattctag 39780 agataaattt tagccttatg agtgatgtgc ctgtatcatc ttaatttgta gttttaccct 39840 tttgatttga ttaacaaaag cttaaacatt cagagaaata gactaatata acatccatat 39900 aatcattacc tagatttaat agttgccctg tttgcttaat cttttatttt actgaagtat 39960 Página 58 tttgaagttt cagatgttat gctttacctt gattcttgag caagcacctt tagagaattt 40020 ctagaaaata ataataatac tataatctgt ggggtgcagc taaatcggtg ctgagaggaa 40080 agttcataag attaaatatt aaaataactt ttgattaata tgttaataaa aatgaaaaaa 40140 cattcaaccc tgttaaagtt catagaacaa acttctgtaa gtggtactgc atccaggagt 40200 ttgtcttatt tatttatttt ttgagacaaa gtcttgctcc gtcgcccagg ctggagtgta 40260 gtggcgtgat ctcagctcac tgcaatatcc gcctcctggg ttcaagcgat tctcatgcct 40320 cagcctttgg agtagctgac actccaggca taagccacca tgcccagcta atttttgtat 40380 ttttagtaga gacggggttt caccatgttg gccaggctgg tcttgaactt ttggcttcag 40440 atgatctgcc tgcctcagcc tcccaaagtg ctgggattac aggtgtgagc cactgtgcca 40500 ggccagagtt tgtcttttaa aaagatttct catatatgta aaagcatttc caaggctgct 40560 gattgcatgt ctttttattt tttttaattc cctacttcca tttcacagca tattatactc 40620 ccctttaagt actatatggt atatatgtct ttttccacat tgaatcactt ggagggattt 40680 ttgtatgtgt gtgtgatgtt tttgtgtttg agacctctgt gatgtcttta tttatgtctg 40740 aggtaaaacc accattgagt ttggccatgt tataaaccag agaataaaag gatgaactaa 40800 tcatttactt tatttactaa caggtgttca atatgaatgc cccagttcct cctgttaatg 40860 aaccagaaac tttaaaacag caaaatcagt accaggccag ttataaccag agcttttcta 40920 gtcagcctca ccaagtagaa caaacagagc ttcagcaaga acagcttcaa acaggtacga 40980 aatccagtgt cacctcattg gctccttgct ttccagcaca gttattgaca gtgttaggac 41040 agtttagact tcagagtggt ggtgtccaag agtttctgtt ttagtagcag accatatgaa 41100 tttttcattt cagatcatga gttaaattga gtctgtactt gtatatgtga attatgtgca 41160 atttttggag gctttatagc cattttcctt ttgtcactga acttacataa tatccctgtt 41220 gcattgtata atttatatgg aattaaattt gttacttgaa ttaccataaa gtgtactttt 41280 tttttttttt ttgagatggg gtctcactct gtcacccagg ctggagcgca gtgccgtgat 41340 ctcggcttac tgcaacctct gcctcctgga cacaagcaat cctccctacc tcagcctccc 41400 aagtagcttg ggaatacacg catgtgccac cacgtccagc taattttttg tatttttggt 41460 aaagttgggg tttcaccatg ttgcccaggc ttgtcttgaa cttctgagct cacgtgatct 41520 gcccacctca gcctcccaaa gtgctggaat taaaggcgtg agccattgca cctggtgata 41580 aactatactt ttaattgtta attgattgaa ggcttttagc atgatatctg gcattgagtc 41640 agttagacaa agttaagaaa aaactcatgg tggctgcatt tcgtggactg ggttgaaaca 41700 taatctattt tgtcaagtaa ggtcataatt tggctagtta ccatacctgt cacgatagta 41760 atgtaggtag ggacgctttt atgtatttga gacaggttct cactttgttg cccgggctgg 41820 agtgcagtga tgccagcata actcactgca gcctcaaact cctgggctca atgatcctcc 41880 tccctcagcc tcctgagtag ttggtagttg ggactacagg tgcttaccgc catggctggc 41940 taattttttt tttttttttg tagagatagg gtctccagga gctcactatg atgccaggct 42000 gatctccaac tccttgcctt gagcgaactt attgtctctg tctcccagag tggtgggatt 42060 Página 59 atgggcatga actaccttgt ctagctcgat agagatactt tagatttttt tttatatata 42120 tattttttta agaaatgggg tctctgtctg ttgcccaggt tggagtgcag tggtgtaatc 42180 agatactgga gcctttaact ctggggctca aatcctgtac tggagccttt aactccccac 42240 aagtagcttg gactgcaggc ttttctcaaa ctcagggcct ccagcagtcc tcccacctct 42300 accttatagg catgagccac catgatgtct tctttagttc tttaattcct cagaatttaa 42360 ttggaatccc acaacaaacc agcagtcaga ggagttaata ctttcatttt gtcagcccga 42420 ttttgaaaag ttgtaaaatt ttctaattat tcaatttctt ggtaaacttg gatcagcatt 42480 agatttttca gtagtaaatt cttacacatc ctgtagtatt cagtatcact aatatgaagc 42540 tcgaatcttc catactctga tagaagttat cagttatact atgctcagct tccaaatgat 42600 aaaaactagt ggtgtgatca ccatggctca ctgtaacctc tgcttctggg ttcaagggat 42660 cctcctacct cagtctccca agtagcacag gccaccatgc ctggctaatt tttttttttt 42720 ttgtattttt agtagagaga gggtttcacc atattgtcca ggctggtctc gaacaccagt 42780 cacatacgca gcaagttctc tttaatctca gggccttcat acttactttc cttcttgccg 42840 aaaactttct cccactgata agtacatgga ttgctttttc tattttttta aaaaaagttc 42900 atttgtttat ttttaattga gaagtagaaa ctatatatat gtgtatttat ggtatacagc 42960 atgatgtgtt gaaatgtgtg tccgttgtgg gcgggcttca tggctggcac ctataatccc 43020 agctacattt gaggctgagg tggcaggatt gcttgaggcc aggcgttcat gatgaaataa 43080 tatgtataca ttgtgggccg ttgtccagtg cagtgatgca gtctcggctc actgcaacct 43140 ccgcctctta ggttcaatcg cttgggttca agcgattctc ctgcctcggc ctcctgcctc 43200 aggcctcagg tgatccaccc gcctcggcct tccaaagtgc tgggattaca ggcgtgagcc 43260 accattcccg gcctgatatt tgttgaagaa atcatttcag tatgtcccat cattttagaa 43320 attttatttt gaattagtgt ctaatcagga acaacatgac agaatctttg gctttttaaa 43380 atggcctaca agtttatact ttaccaaaat ttaagtagga atttgggtat tttaaaataa 43440 aatgaaggct gggtgtggtg gctcacgcct gtaatcccag ctctttggga ggcccacttg 43500 agaccaggag tttgagacca gcctgggcaa cacagagccc cacctctata aaataaatac 43560 agaaattagc agggtgaggt ggtgaatgcc tgtagttgta gctactcagg aggctaaggc 43620 cggaggatca cttgagccca ggagttcaag gttgcagtga gccaagatta tttgactgaa 43680 ctccaacctc agcagtactg ggtgagagag ctagaccttg tcttaaaagt gaaaattaaa 43740 taaaataaag atcacactta agttattatg ctgtgagttt cttcctttct ttcctttcct 43800 ttttcctttc attttttgag acagagtctt gctcttgtct cccaggctgg agtgcagtgg 43860 tacgatctcg gctcactaca acttcttcct tccaggctta agccatcctc tcacctcagc 43920 ctcccaagta gctgggacca caggcatgca ccaccatgcc tggctaattt tttgtatttt 43980 gttgttgttg ttgttgttga gatggggtct cactgtgttg cccagctggt ctcaaactcc 44040 tgagctcaag taatctgctc agcttggcct cccaaagtgc tgggattacc agtgtgagcc 44100 actacaccca gcctggctat gaatttctta cagtgagatt tgatcaagat taaaagctgt 44160 Página 60 tattgataaa atgattctaa aattcagttc ttttggctac tttgtacatg gatacacatg 44220 aaccatttta caaggaaaat gttatgtgta tttgtcattc acttacaatt ttaaattttg 44280 ggaatataat aaaaggcaat ctatgtaaaa agatgacacc gatgtagttg gtttactaag 44340 taattcaaga ggagcagtgg ctctctcttt ttctctaggt attccctagt gctttcatcg 44400 taaaatagga ttctaacaac tattaatgta tttggagttt cttaagggtg taaaataggt 44460 caagtaaaga ttttcaagag tcatacagct gcttttctct ctgccccaaa aggggagatt 44520 tgggttggcc agcagcttct gacccttgtt gttagtgtgt gggccttcct ttgttctgtt 44580 gccttcctca cctcccaaag gtacttttag caccctattt ttttctcctc tttgaattat 44640 aaacattgtt ctgtagtatt gaatttttga aaatttctag attctagaac tctgtccatt 44700 gtggatggag cttgtatata tgttagtgtg taccttagtc tagaaccttc aagtgggttg 44760 agtgccaatg tgagtaccat gtgattgttt tctaaattgg ctatacttgc cattttaaat 44820 actttgaaat ggaatttggc attaagggct acaagtcgaa ggcctctgct gattaaacta 44880 tgtagttgat gacatattct accatctagc tgcttaaata tgagagagtg gttttgtatg 44940 ttttactaag taaaaaaaag gatatttaaa agaataagaa aacttctacc actaaggagc 45000 tttataatga aaagaagtaa ttaaatggta caaaatggta atgtactaag agtaaatctt 45060 ttgagttatt ttgggtctct tgtgctaaaa agtagatgcc tttcagaaga cgttaatata 45120 gcctttcaaa taatttgttt ggaaggatca atcatgcacc ctgctttcaa aggtttggaa 45180 ttgtggttgg agaattttac ccccaatagc tgagtctaag ggtaggagaa aggtaagaga 45240 ctttattcat gtgtagtttt tcttatcatt gtatgcaaat ttaaggatta aactttaagg 45300 agactgtata agacacttct taaactagaa agtgcgtggg agaacaaacg gtaatgagct 45360 gtttatgtat atatcttttt cttttttaaa ttatagtggt tggcacttac catggttccc 45420 cagaccagtc ccatcaagtg actggtaacc accagcagcc tcctcagcag aacactggat 45480 ttccacgtag caatcagccc tattacaata gtcgtggtgt gtctcgtgga ggctcccgtg 45540 gtgctagagg cttgatgaat ggataccggg gccctgccaa tggattcaga ggtaaaaaaa 45600 taaaaaagga ggttctaatg accttttact agttcaaatt attttttgat ttgtaaaata 45660 tatcacacag tttttgggaa ggatgtatct gcattagcct cctatgtgca atttaaacaa 45720 tgtatatttt ggtacaattt gtgtatttgg tataatttgt tatttaaata acagatcatg 45780 gaatttttgt tcatttggtt atgtcaaatt aatgtctacc actatctcct ggaggataag 45840 tattttccac attaccaaaa cttacgggga ttgtttatta tatttgtaca gatgtgtgtt 45900 tacatgcata gatgggttaa aagtttatct tctgaggggc agttagtact tacagaaatt 45960 tataaacaga ttggatcaag ataggaaatt ggagattaat ttgattaact agcctggctt 46020 ataatttcta gttcttcccg tcttcattaa taaaaaagta aaaattcctt gtgaagataa 46080 gaaaattatt tcttttcttg tcctaaattt taggaggata tgatggttac cgcccttcat 46140 tctctaacac tccaaacagt ggttatacac agtctcagtt cagtgctccc cgggattact 46200 ctggctatca acgggtaggt aaagtagttc taaagtgtaa acctgaacta aatataccaa 46260 Página 61 tgaaagtgac ttagtgttgt tgcttaatga acctaagtaa ctaatttggc gttaactttg 46320 tggtgtccaa gacactctgt tgaaacaaaa gcttttagca ctcaacatca gtactccttt 46380 agtaaagcct gttaaagaca gtgatttcca agagcagaga aatatatttc actgaatgtt 46440 ctttgagaat agtagaagta caacaattac agaacaaggt gtagctgtga taaactgata 46500 ctgaagtgtc taaaagatta aggaagaatt ctgtattgag tgttagactg aaagaataga 46560 tgggtaagca ttttttaaaa agtacctttt caatactaac tagcttgtct tttaggatgg 46620 atatcagcag aatttcaagc gaggctctgg gcagagtgga ccacggggag ccccacgagg 46680 taatattttg tggtggtgat cctagctcct aagtggagct tctgttctgg ccttggaaga 46740 gctgttaata gtctgcatgt taggaataca tttatccttt ccagacttgt tgctagggat 46800 taaatgaaat gctctgtttc taaaacttaa tcttggaccc aaattttaat ttttgaatga 46860 tttaattttc cctgttacta tataaactgt cttgaaaact agaacatatt ctcttctcag 46920 aaaaagtgtt tttccaactg aaaattattt ttcaggtcct aaaacctgct aaatgttttt 46980 aggaagtact tactgaaaca tttttgtaag acatttttgg aatgagattg aacatttata 47040 taaatttatt attcctcttt catttttttg aaacatgcct attatatttt agggccagac 47100 accctttaat ggccggataa gccatagtta acatttagag aaccatttag aagtgataga 47160 actaatggaa tttgcaatgc cttttggacc tctattagtg atataaatat caagttattt 47220 ctgactttta aacaaaactc ccaaattcct aacttattga gctatactta aaaaaaatta 47280 caggtttaga gagttttttg tttttctttt actgttggaa aactacttcc cattttggca 47340 ggaagttaac ctatttaaca attagagcta gcatttcatg tagtctgaaa ttctaaatgg 47400 ttctctgatt tgagggaggt taaacatcaa acaggtttcc tctattggcc ataacatgta 47460 taaaatgtgt gttaaggagg aattacaacg tactttgatt tgaatactag tagaaactgg 47520 ccaggaaaaa ggtacatttt tctaaaaatt aatggatcac ttgggaatta ctgacttgac 47580 tagaagtatc aaaggatgtt tgcatgtgaa tgtgggttat gttctttccc accttgtagc 47640 atattcgatg aaagttgagt taactgatag ctaaaaatct gttttaacag catgtaaaaa 47700 gttattttat ctgttaaaag tcattataca gttttgaatg ttatgtagtt tctttttaac 47760 agtttaggta ataaggtctg ttttcattct ggtgctttta ttaattttga tagtatgatg 47820 ttacttacta ctgaaatgta agctagagtg tacactagaa tgtaagctcc atgagagcag 47880 gtaccttgtc tgtcttctct gctgtatcta ttcccaacgc ttgatgatgg tgcctggcac 47940 atagtaggca ctcaataaat atttgttgaa tgaatgaatg aatgagtact ggtggaatac 48000 tccattagct ttactcttct tttagctaag agaacatgag caaatttgcg catgacaact 48060 tccaggacag gggaaacttg aacactgaag aattgacctc ttaagcctaa taatgtggtg 48120 acaggctgcc cacatgcttc ttgacttcag atgaaaatct gcttgaaggc aaaacaaata 48180 atatttgaaa gaaaaatcaa atgccatttt tgtcttctag gtcgtggagg gcccccaaga 48240 cccaacagag ggatgccgca aatgaacact cagcaagtga attaatctga ttcacaggat 48300 tatgtttaat cgccaaaaac acactggcca gtgtaccata atatgttacc agaagagtta 48360 Página 62 ttatctattt gttctccctt tcaggaaact tattgtaaag ggactgtttt catcccataa 48420 agacaggact acaattgtca gctttctatt acctggatat ggaaggaaac tatttttact 48480 ctgcatgttc tgtcctaagc gtcatcttga gccttgcaca tgatactcag attcctcacc 48540 cttgcttagg agtaaaacaa tatactttac agggtgataa taatctccat agttatttga 48600 agtggcttga aaaaggcaag attgactttt atgacattgg ataaaatcta caaatcagcc 48660 ctcgagttat tcaatgataa ctgacaaact aaattatttc cctagaaagg aagatgaaag 48720 gagtggagtg tggtttggca gaacaactgc atttcacagc ttttccagtt aaattggagc 48780 actgaacgtt cagatgcata ccaaattatg catgggtcct aatcacacat ataaggctgg 48840 ctaccagctt tgacacagca ctgttcatct ggccaaacaa ctgtggttaa aaacacatgt 48900 aaaatgcttt ttaacagctg atactgtata agacaaagcc aagatgcaaa attaggcttt 48960 gattggcact ttttgaaaaa tatgcaacaa atatgggatg taatccggat ggccgcttct 49020 gtacttaatg tgaaatattt agataccttt ttgaacactt aacagtttct ttgagacaat 49080 gacttttgta aggattggta ctatctatca ttccttatga catgtacatt gtctgtcact 49140 aatccttgga ttttgctgta ttgtcaccta aattggtaca ggtactgatg aaaatctcta 49200 gtggataatc ataacactct cggtcacatg tttttccttc agcttgaaag ctttttttta 49260 aaaggaaaag ataccaaatg cctgctgcta ccaccctttt caattgctat cttttgaaag 49320 gcaccagtat gtgttttaga ttgatttccc tgtttcaggg aaatcacgga cagtagtttc 49380 agttctgatg gtataagcaa aacaaataaa acgtttataa aagttgtatc ttgaaacact 49440 ggtgttcaac agctagcagc ttatgtgatt caccccatgc cacgttagtg tcacaaattt 49500 tatggtttat ctccagcaac atttctctag tacttgcact tattatcttt tgtctaattt 49560 aaccttaact gaattctccg tttctcctgg aggcatttat attcagtgat aattccttcc 49620 cttagatgca tagggagagt ctctaaattt gatggaaatg gacacttgag tagtgactta 49680 gccttatgta ctctgttgga atttgtgcta gcagtttgag cactagttct gtgtgcctag 49740 gaagttaatg ctgcttattg tctcattctg acttcatgga gaattaatcc cacctttaag 49800 caaaggctac taagttaatg gtattttctg tgcagaaatt aaattttatt ttcagcattt 49860 agcccaggaa ttcttccagt aggtgctcag ctatttaaaa acaaaactat tctcaaacat 49920 tcatcattag acaactggag tttttgctgg ttttgtaacc taccaaaatg gataggctgt 49980 tgaacattcc acattcaaaa gttttgtagg gtggtgggaa atgggggatc ttcaatgttt 50040 attttaaaat aaaataaaat aagttcttga cttttctcat gtgtggttgt ggtacatcat 50100 attggaaggg ttaacctgtt actttggcaa atgagtattt ttttgctagc acctcccctt 50160 gcgtgcttta aatgacatct gcctgggatg taccacaacc atatgttacc tgtatcttag 50220 gggaatggat aaaatatttg tggtttactg ggtaatccct agatgatgta tgcttgcagt 50280 cctatataaa actaaatttg ctatctgtgt agaaaataat ttcatgacat ttacaatcag 50340 gactgaagta agttcttcac acagtgacct ctgaatcagt ttcagagaag ggatggggga 50400 gaaaatgcct tctaggtttt gaacttctat gcattagtgc agatgttgtg aatgtgtaaa 50460 Página 63 ggtgttcata gtttgactgt ttctatgtat gttttttcaa agaattgttc ctttttttga 50520 actataattt ttcttttttt ggttatttta ccatcacagt ttaaatgtat atcttttatg 50580 tctctactca gaccatattt ttaaaggggt gcctcattat ggggcagaga acttttcaat 50640 aagtctcatt aagatctgaa tcttggttct aagc 50674 <210> 7 <211> 3939 <212> DNA <213> Homo sapiens <400> 7 aaagaaatta gagcaacagg ggtctcagca gggtggtctt gggccaaaca ctgaaagcag 60 gcaggcttac cctttcctct tctgccccct tcaacttttt cctgatgttc ttacccacat 120 ccctcaccac accacaccct ttcattcatc cttgtcccag acttattaag tatatacaga 180 taagcaatcc agggaacttg cattcattag gagaaaccca gaaattcaaa agcaataatg 240 atctaatccc agaggagtag aaaacaggaa gtgggcagct gccagctttc ttgctttgct 300 ggagtattct ggaatttgat gggttgaggg ttctggacac aatgccccaa gccccttcct 360 tgttgtgctg ggttcctatt tctgctctcg gcactgactt agcagctgct caagagctca 420 ctatgttggc ttggattaca cggtctcacc cacatctccg gcagtttgtg ggcaaacttc 480 ctgagcagcc ttgggtgatg aaacctttca tggtagcagg agaatgggac tgtgaattct 540 caatcccctg tccccacccc ttccttcctc tctcagggcc ttaaagtcta ggaggaggaa 600 gcacagcagc aactgactgg gcagcctttc aggaaagatg cagccactcc tgcttctgct 660 ggcctttctc ctacccactg gggctgaggc aggtgagtga ccatccccac cctcagaggc 720 ctgacctcat cccatagatt cttgagccaa attgccttgg tatatcctaa ttctgtactg 780 ttgagcaagt tatttgaatt tgtgtttcct catctataaa atgagaataa tattaatacc 840 gatcttgcag agttgccatg agagttaaat aagttagagt atttaaatgt cttggaattg 900 cccgcacact ataagtgcta taaaaacatg ctttgtgtaa ataatttggc agcatgtgtc 960 agaccctacc taggaggtaa gaatacagca ataacagtac catcagctca tgtctagatt 1020 tttaaacacc agtcccacgt ggtcttgaat tggactcaga gggctctggg aagctccatg 1080 aggataaaag tataagggaa cttcaggaac aatcctgtac ttacagcaaa gcattctcct 1140 caatacctga ggctgaagct ggccttgcct ggaacaaggg ttgttctccc tcttttggag 1200 aggaggaggg aggtgaggcc taggatgggg aaaagggctc ctttcaagac agcagtgttt 1260 cctgtagaac cctggagccc cctcccaatc tgctgcccca tagactccaa gcctcagcac 1320 catctcctcc ctctcctgca ccctctctcc tgccgtcccc atcttccagc ctttctggag 1380 ccaccaatct ggtacccaca ttgcaggttc agcaagcata gagctaagtg ccaaatgctt 1440 ccttccaggg gagatcatcg gaggccggga gagcaggccc cactcccgcc cctacatggc 1500 gtatcttcag atccagagtc cagcaggtca gagcagatgt ggagggttcc tggtgcgaga 1560 agactttgtg ctgacagcag ctcattgctg gggaaggtga ggagctaagg aacttcctgg 1620 Página 64

P201430887 ES 2 553 786 A1 09-06-2014 ccagccagga acacagccct gcggagctct tcggtggaag agccatctga aagaagagtt 1680   gtagcaatga aagggtgaaa gaaagaccaa gtgagtcttt gcgggaggga acaggccagt 1740 gtaaatgagg aggaaaggag gataagatca aaaagagcaa gaggaagaga tggaagacac 1800 atattggggc tcaaaatata aactcaggct atttatcaac ttaatctggg gaagcaaacc 1860 tgaaggcaag taccaccctg tcatccctag ctcagagctg ctgagaaaga ggatacagct 1920 gagccccagg gccctcccat cccctcgatt ctggttagct gcagtcttgc cctccccgtg 1980 ctgtctgcct accctgcaga gctggtggac catagctcct gcagcccaga cctacctctt 2040 gcttttgcag caatataaat gtcaccctgg gcgcccacaa tatccagaga cgggaaaaca 2100 cccagcaaca catcactgcg cgcagagcca tccgccaccc tcaatataat cagcggacca 2160 tccagaatga catcatgtta ttgcaggtac cacctacctg gccctctggc tccttcctag 2220 tgtgtccggg gacaatggag gaggaagtga gggcaaggct ccggggtggc ggggagggca 2280 tgggatgtgt actgcaccag cgacccccga gccttggctg gaggccccag ctgagcggga 2340 acgcctacat tcttcctcca gctgagcaga agagtcagac ggaatcgaaa cgtgaaccca 2400 gtggctctgc ctagagccca ggagggactg agacccggga cgctgtgcac tgtggccggc 2460 tggggcaggg tcagcatgag gaggggaaca gatacactcc gagaggtgca gctgagagtg 2520 cagagggata ggcagtgcct ccgcatcttc ggttcctacg acccccgaag gcagatttgt 2580 gtgggggacc ggcgggaacg gaaggctgcc ttcaaggtaa ggcatgggca ttggccaaca 2640 caccccggga gagaggggcc cgtgcagagc caggcagtgc gaacagattc catccccaca 2700 gcctcagcct ggcagccaga ccagggtggg ctggggattg ttttccccat caacctggtc 2760 tctgggggaa taggaggaag acccacaaca catacatagg caacattctc ctggagaagg 2820 gagaggtacc ttgactcaga ttgggctgga gacagtaatt aaggcagagc tgaagtccag 2880 cgaccgaaaa gatccagagg cttggctcct gtaccccacc gatcttccat ctcacacaca 2940 cccagcaatt gaaggggccc acccacccct gccttccctg agagcccgga gctcagggaa 3000 gcaggagcag ggaggcctgt ctcagtctcc cttctcctct ctacctacag ggggattccg 3060 gaggccccct gctgtgtaac aatgtggccc acggcatcgt ctcctatgga aagtcgtcag 3120 gggttcctcc agaagtcttc accagggtct caagtttcct gccctggata aggacaacaa 3180 tgagaagctt caaactgctg gatcagatgg agacccccct gtgactgact cttcttctcg 3240 gggacacagg ccagctccac agtgttgcca gagccttaat aaacgtccac agagtataaa 3300 taaccaattc ctcatttgtt cattaaacgt cattcagtac ttagtttgtt tggattgcta 3360 caacaaaata gcacaaattg ggtggcttat aaataacaaa tttatttctc acaggtctag 3420 aggctaagaa gtctaagatc aagtcactag cagattcagt gtctaattag ggcccatttt 3480 ctggttcaca gacaaccatc ctctccctgt gtccacatat ggcaaaaggg gcaagggaat 3540 tctctgatgt ctcttttaca agggacctag tctcattcaa agagctcagc ttttacgacc 3600 taatcacatc ccaaaggccc cacctaatgc catcacattg gggattaggt ctgggaaaca 3660 tagggaaaca ctgtctctac acaaaaattt taaaattagc caggcatggt ggcatgtgtc 3720 Página 65

P201430887 ES 2 553 786 A1 09-06-2014 tatagtccca gctacttggg aggctaaagt ggaaggatta gttgaaccca cgaggttgag 3780   gcttcagtga accatgcact ccagcctgag cgacagagca agacaccatt ccaagaaaga 3840 aaaaaaaaaa gactggcagg ccaaaaagac agaactgaaa ttccaaaaaa aaagacctac 3900 tttagtgtat gaaaaaggtg gcatctcaaa tcactggga 3939 <210> 8 <211> 33141 <212> DNA <213> Homo sapiens <400> 8 cctgccgcca cgcccggcta atttttgtat tttttagtag agacagggtt tcaccacgtt 60 ggccaggctg gtcttgaact cctgacctca gatgatccac ccgccgcggc ctcccaaact 120 gctgggatta caggcgtgag ccaccgtgcc cagtcaattt aaatgttttt aatttcacaa 180 cttacattct agcttcaaaa atatatttta cattattacg aaccactcac caagatttta 240 tggccagata cccaaattca tctcagtctc caagtgcaaa ttttaaaact aatttcttcc 300 atcattcaat tcaagcagaa tggtagagta gtattttaga acagatagaa ctagtaaatc 360 ccagctctgt gaacatactt tctctgttac cttggccaag ttatttgcta aaggcatttg 420 cttcccatcc tgtatctgta aaatgggtat ttcctattgc aaaaggtaga taagtagcat 480 gtgcttggtg ggttagtgtt tttccctctc cagctggaaa aaaaaaacct ggtgtggggg 540 aagaagggga acagtttgtg caacagaacc ctaagaggaa atcagctgct catcaagata 600 agggctgagg cataaaactg ccagagggtc tcaaggcagg caaagaagaa ccatgaggct 660 catcctgcct gtgggtttga ttgctaccac tcttgcaatt gctcctgtcc gctttgacag 720 gtaaatctta cttcctgtgt tccagtctct gtgtagaaga gaattaaagg ttgtttcctt 780 acagttcact tttttttttt catttgcctc cacaaaggga gaaggtgttc cgcgtgaagc 840 cccaggatga aaaacaagca gacatcataa aggacttggc caaaaccaat gaggtaagca 900 tttagaggga tattttatct tttcttactg ttctctaaaa gatgcttctt cttattttac 960 tgtcaatgcc catgggacta caaaagacta ttgaacataa ggggaaagca ggagctatct 1020 ggataattca gccaatggcc aatacttcac ctgttctggt tttggtcttg gtttccaaga 1080 ctaccacttc tgtttttcct cccaaaagct tttcaaacac cagctttttc aaggtaaaac 1140 tatgaaatca ggagctgttc ttggcctcct tatcagggca tctttctctt gcctacgggt 1200 gccattccct ctccattctc cccactccga ccctcatctc ctctggtgcc ataatttctc 1260 ttgagtacta actgaaaacg ttgaggcact ggctaatatc aagatgtgac cctttccaag 1320 agcaggtaca ttttcaaata agacttttaa agttagatca atcctttaaa atccaacagc 1380 ctaatataat tttatcatgt attcagctgc tcctatttat gttgcaccag ccaccttata 1440 tatgccattt caaattctcc agcagattct caatgtcagg gttataatgt aactcatttg 1500 aaacagaaga gctaaagtgc aaagacaata aattaaatga ccaagattac acatcaaatt 1560 taaacccaga actgggtctg ggatttattc cagtcaaaca tacagttacc tctacatcaa 1620 atcaatcaaa ggccctgcct attctaactc ccaaatgttt ctcaaatcca cacattgccc 1680 Página 66 tccattccac tgccactgcc aagttcatgt tcactctacc tcttgcaagg agaatttcca 1740 tagtccctta actagcaatc agggctctag tcttgactcc cacaaagcca actctgcatt 1800 gcaacctgat tgctcactct aaaacttgac aattgcattc ctccgtttga gggtcattac 1860 taagaagcag cctagtacgg aaaaagcatt ttcttcaaag tcaaacgctt acattcaaat 1920 ccaagctcta cgctagctct gtagccttag gcaacttact caacatctct gggtctcaat 1980 ttcttctgct ataaaatggg gataatagtc atagctactt cctagggttg ctacaaagac 2040 taagtaagcg tttgatagca cttagaagca ggcctgccat attaagcacc atagaagcgt 2100 tttttgtttg ttattgtttt tgttttgaga cagagtctca ctctgtcacc caggctggag 2160 tgcagtggca caatctctgc agcctccgac tcccaggttc aagcgattca cctgcctcag 2220 cctccctatt agctgggatt acaggtgccc accaccatcc ccggctaatt tttgtgtttt 2280 tagtgaagac ggggttttgc catgttgccc agctggtctc aaactcctga cctcaagtga 2340 tccacccgcc tcagcctccc aaaatgctgg gattacaggc atgagccacc atgcccagtc 2400 agaagcattt tcttttggta ttggtatagc attcaaagcg ttttatgatc tgccaaacta 2460 ccagcctctt caatatcctg ctcctccacc ttcttccaca cccttcaagc cccataaaca 2520 ccaaaatctc acccaccttg gccctgtaca tcttttctca tgaaaatgtg tttctctccc 2580 ttttgacctg ggtaagtcct acttatttct caagatccaa ctcaggcagt gtctcctgca 2640 ggacgtctct tctgttcatc aactctcgtg actcagtttt ggctgctcct tgtgctcctg 2700 gaatacccgg ttccttcctc tggcattggt taacatgtgg gaaacatgca tgtatgactc 2760 tgtgttccac accaaacctt tcacatctca taagtccctt attagtctct acaactgtgg 2820 cacccagctc tttgcctcct gcttaataca tgaaagttca ctaagctcta agctcctgct 2880 gcacattacc ctgctagaac acagaaatgt ctattgtgat aagatggctc tgcctaactt 2940 gcctttgcat cacactacat ctctcatatg tccaactcat gatgtagctt tttgatcaaa 3000 ataaacattg gttggttcat agcagcctca tattgtcact tgattgacct cgaggtagag 3060 ggggactcaa ccaagaaaca gccaggcaga cctgaacaca tacacaagca ggggtggaaa 3120 ttgagctttt ccttcacatt tcccaggctg gggacttgta cttcatttag tttcacaatt 3180 gagtatgatt ttgaagaacc acaagaactg gaatcttttc aatgtttgct tttgtttttg 3240 ttttttgtgt tttttctgag acagagtttt gctcttgttg cccaggctgg agtgcaatag 3300 cgagatctcg gctcactgca acctccacct cccaggttca agcaattctc ctgcatcagc 3360 ctcccgagta gctgagatta caggcatgtg ccaccatgcc tggctaattc tctattttta 3420 atagaagtgg ggtttctcca tgttggtcag gctggtctcg aactcccgac ctcaggtgat 3480 ccgcacctca gccttccaaa gtgctgggat tacagtcgtg agccacaaca cccagcctcg 3540 aaattatttt gatctgaatg ctatacttct gagctcatat accaaatttt tgaaattgtc 3600 agctagagga agagaaagga aaaaaaaatc tgcacctgtt aactgtcttc atgccccaga 3660 cctcagacct atttcacaat cttcacaaca cttcccagtg gaccctcatt tgccccatta 3720 tttcaggaga gaggagtaaa atttaaagag tcctagtaac ttgcccaagg acatattgct 3780 Página 67 agaaaaatga ctttgctggg ggtctatgcc aactgtttga tacaatatct tgtatcagga 3840 tttccagagt ttatagggac atcaggtttt gaggactaac taaccagata tttaacttaa 3900 atttccaatt agaggcagat tctgtggcta gatgaattgt gatcccattc aatcccaaaa 3960 ttgtggaaga aaaaaattaa ccaaaagatc tgcccatcct ttttaacttg atagacctga 4020 agtccttaaa aaaaaaaaaa gtgatcaggc actaggaagg tttctttcct cctccctaat 4080 attcaacagt tcttaaatat atttgcaaaa atcccataaa cttattaaaa gaagggtctg 4140 tatcttagtt atgctgagcc ccaaattcct ttcatggtgt atgagacatg atcatttctt 4200 aatcaataag tgttgggtaa gcaaataaac tctgactaac attgagctta tctctgcagc 4260 ttgacttctg gtatccaggt gccacccacc acgtagctgc taatatgatg gtggatttcc 4320 gagttagtga gaaggaatcc caagccatcc agtctgcctt ggatcaaaat aaaatgcact 4380 atgagtaagt ccttggcaaa tattgaaatt tgttggatat tcaaagtttt gggagccttg 4440 aagtagagga aagtattaca atggacctat ttttaattgg gccccccaga acgaaagctc 4500 tttctgtaag atacagatca cagttacttc caaacacatt atcgaagcct gtttacagag 4560 gtgatagaat caaacttggc agttcaacat ctaccttaca tttgctctta gctataagaa 4620 taacaattac ctatatctac catctccaaa accagcccct cataagcaca gagcccacat 4680 gagcaggcat gaatggttta gccacatgtc atcactactg acaggtaatc ggcccagatc 4740 tcatgagcta ctggcgctgg cctcctttta tatatttgaa ttttcctgat acataaaagg 4800 agaccaaaaa aaaaagtcat tggtatgtca gaaatacagc aattggtatg tcattggtat 4860 gtcagaagta cagcaattaa aaatatacaa taaataattc tttatgaaaa aaattcttcc 4920 tcagagaaag cacaagcaga gcagtagaat acagtttaaa tcaaagagaa aagaatctca 4980 aatagccaaa gatgcagaaa tgagtcattc tggccccaca gagaagtaag agaaaatctg 5040 aatatattga gcagcaacca tgggccatgc ccagtctggg ccctgggcag tgaatgagaa 5100 ggaagcccag caatgaatat cataaatcaa tgtgtaattt agaaaataaa atgtgttggc 5160 catgcgcagt ggctcacgcc tgtaatccca gcactttggg aggccaaggc aggtggctca 5220 tgaggtcagg agttagagac cagcctggcc aatatggtga caacccatct ctactaaaaa 5280 tacaaaaatt acctgggcgt ggtggcgtgt gcctgtagtc ccagctactc gggaggctga 5340 ggcagaagac tcacttgaac ctgggaggca gaggttgcag tgagccgaga tcgcgccact 5400 gcactccagc atgggtgaca gagcaagact ccatctcaaa aaaaaaaaaa aaaaaaaaaa 5460 agaaaatgtg tttttatact ttcaaacatt tcatagtttg atgtacagag ggatcccatt 5520 ttaacttccc caggccatgt tatgccagga ttcccctttg ttgagaccct cattgtcaaa 5580 acactgctaa acactagttc attttttttt tttgaacttg ccattttata cctccattac 5640 ctgacttggt actttaactc aaaaggtctg cttctggctg agataaagaa agagcctgtt 5700 gatgtcagtg atgttatatt gcagagcagg atttactact gctcaccata aacttgattt 5760 tatttatgat attgccacaa tatctcaaat aaactccatt gaaatttaaa aatcacgtac 5820 ataagtgagc aaaaaacatt cttattcacg gctttaaaga taacattcta ttatttgtga 5880 Página 68 tggttattga tgactttttc ggttttgtta ctgtttcaag aaggttgtgg cagaaatgta 5940 aaagttaaca aattgaaaat atataattca cgctgtgcac atgtacccta gaacttaaag 6000 tataaaaata tatatttata aaaaaaacta attgatacca gcttttaacc cttttaactt 6060 aatatactaa gtttttctgt ttttataaat cacatcatta aaattagaca cttcaaaaat 6120 gtaactacaa gactgcagaa atttgtatta cattatctgt ttacattaag gttcagataa 6180 tgtattgact ctttcatcta aaagaaatca accctctatc ttaaataacc cctggttact 6240 gtgtctcttg ttttgttttt tgagatgaag tctcgctctg tcacccagac tggagtgcag 6300 tggcgcaatc tgggttcact gcaagctccg cctcccgggt tcacgccatt ctcctgcttc 6360 agcctcccga gtagcttata ctacaggcac ctgccaccat gcctggcttt tttttgtatt 6420 tttagtaaag acggggtttc accatgttag ccaggatagt cttgatctcc tgaccttgtg 6480 atccactcac ctcggcctag ccaccgcacc aggcctactg tgtctcttga ttcacttcat 6540 tgccagcttt ctagtatatg tgcctaaatt attacactct tcactttact tcaataatat 6600 agacctggtc tggattccta tgataaacta attcttacaa agcattcagc ccaaggtaaa 6660 ataaagtagt ggtgtggcca aattttatat aatttggctt gaacagcaag gtaaagaatt 6720 aggtattatg ttttccttaa tagccctata acgcagttac aatgtagaaa atgtatctag 6780 aaaagctagt tgcttggcat gagcatgaat agtggagtaa atcactgtaa gacacctagg 6840 caggcagcta gcatccttcc aatttatcaa atagctcaca tcagcctttt ttctcctttg 6900 gtcctctagg cctcttctat cctgaaatga ttctgattca actagatgtc taaatccaga 6960 tcctcaaatt agtgtgtttt tcactctgtc ttatgacaaa ggagtttctt gctttctacg 7020 tcaagtacca aagtgttaaa ttacctacaa aaattggttt tatcaaatta aaacatgaat 7080 tctacaaagt ggcccaaatc agccacagtt atgggaaagc caaataatta gatagttacc 7140 tccctcagaa atataaatat gtaaagtgat aagtgcagac aagaactact taaaatcttg 7200 tctccaagta ctaattatat agataatttt atttgcatat taattatatg cattacttgg 7260 tgtcagtcag taacagaaaa gagttctaag aacagaaaca tctggtcgga cccaggcacc 7320 aggctgaatt aaaccatatt aaaaggctgg tttgacacaa agatttactt acacaccctt 7380 cattagacag ggtatatcaa ctactattta gtttaaagca tctgtgtggt ttttctttaa 7440 tttttagaaa attaagttag taagccagat tttattttaa agtagcatac ttgtttcttt 7500 ttttacttat ttacaaaatc ataaaaggcc aagttcaaaa aacaaacaac atggatatac 7560 taacaaaccc aaacagactg gcaaacaaat atcaaaggga aggcacgtcc atcggactga 7620 gcctctgggg cagacactat acttggactc agcagttaaa aatcctagtg tttttaacat 7680 tgttcacatt ttagacagtc aatttttaac attgtctttt ctttgatcaa aggttaaaat 7740 tagaaaataa agagttgtta atgaaaggta actcagaaaa caactattaa tataataaga 7800 aaactcaaat ggtacaatta agtaaaatct tacgaggatc catataagat tatgtgagaa 7860 atgcaaaaga gatctatgcc aaactgacac agtgataatc aacacctaat attaatgtct 7920 aactgcctaa taataatgtt cagtcagata caaattcata ttccagggat atacacagtc 7980 Página 69 ctatccagtg tttcaatcaa atcattctaa tgtgtcattc cattcatttt tttcttctgc 8040 ttcacatttt tacgtattac ttacctaaga gtataacatg catgttatac tacaacatgc 8100 tacatggtac aaatgttgaa gttacaattg gtcatgtgac aaacaggagt gtggaaggta 8160 ggaaagtggg ttctgaagca acgctgtctg ggtccagtcc cactgaagcc atgcattaga 8220 tactcaacat tggcaattta tttaactttg ctttacctca tacctcatct ataaaatggg 8280 aataataatg gaatctattt cataggggtt tcatgaagat tgactgggat cgtaaagttg 8340 ctgtctgcct ggtcctttac ttctatgaat acacacacac acacacacac acacacacac 8400 acacactcac acagaaacag ggaataacta gaggctatca ccagatgttc cattttcctc 8460 ccagtgaata aatgagtagt attcctcaaa ctttgagaaa tccatgtcag taagtgtaga 8520 atttgatgtg tggtaaccaa attagggagt taccaggggg atattgaatc ttagggaaac 8580 ctgaaaccat gctttttgaa tagcaccata tcctgatgta atgtgggcat caggagaatc 8640 cagtcccatt tataagtcac cctgacagtg actctgcctt cctgaaacat ctttccccag 8700 tgcatgcacg cgcgcacacg cgcacacaca cacacacaca cacaccccag agcctacgat 8760 agtcacatat attggcccat agttctccag tcctttgttg ctttctaaaa gcagcaaagg 8820 atgggagcct tgaaactgtc aaagtagaat ttatctcatc tcttctctga acctcttact 8880 tgctccctga ccttgggaca cagacttcca tgagagttgg ttgattgggc caactgtgca 8940 ccaacctccg aagactaagg agagtgcaga tctgacggca atacccaagg atttcactct 9000 catgatgaag gcactattgt acaatggctc acagctacgg tgctgatgtc agaccctcca 9060 ggttcaaatt ccaacttctg tattttaaca gttgtgtcca ttttggaaac tggccaaacc 9120 ttcataaaaa caagagctga taatggtacc cagttaatca tgttgagtga taaaatgtaa 9180 atacagtgct gagaaaagtg cctggcacat aagaaaggtt cagtaaacat taaacatttg 9240 tattattcaa tactcagtga taattattta tcctttcacc tatatttagg aattttctta 9300 aacaaattaa gcaaattttg gagctcaaaa taatatttga gaaaaagtaa tttggtttca 9360 tttgtttatg cctggctgct ggttagtaga agggcttgtg aaaataacat ctggccccag 9420 ttcttaattt ccagccttag gcttaatttc tagtccctat cagcaacaat ctggcaccgt 9480 tctgatgttc tcatgcagct acatcatttg tggaaaggtt gtacttcaac tcacactgtt 9540 ttttttgctt tgttttgttt ggttttgttt tgctgctgtt atcataagag ctaaattgat 9600 atgtgtaagt ctaaaaatat tcttagatac aagcttcctg tgactaatta atactgcctt 9660 atgttacaaa tcaacctctg ggaccataaa atttctcttc tgcctggttt ctccacttct 9720 attaatgcag gtggagcaaa agccacgtgc cctttttaga gcttaaagca attagttatg 9780 tctgtaatga ccacccaaaa tataatttca aaccttcccg ggttttgtgt gagtttcagt 9840 gcaacatgct ccacctgatt ccaaaattgc tgtcacaagt ttattttctc agaaatccta 9900 ggttcatcat aagtcaaaag caaagcatac agtgagttag atatgatgta cataatgatg 9960 tgcttgtcag tgctgctaat aggaatcaat attcatgagc agtacttggt cccatgtgct 10020 aaataaactc taattaaggg aatacagcgt ttgtgttcca catcagaact cagatcagtc 10080 Página 70 agtcaatcag caaggagaaa ccaacaagta gagtggagct cagcagtgtc agtgtcatag 10140 ctcattatta taagaaattg aagaaatcaa agagtcaaac atctacatac catcaaagcc 10200 tgctttaaaa acatgttatg actgtaaaat ggttgtcgat tttatgaccc aacttcacta 10260 ttattctgaa gttcaatggg agcctgaggc caccaagcac ttaggtttta cttcatttca 10320 tcctcaccac aagcctggtc accacaattg taaaagttgg aaaactgagg ttcagagggt 10380 aactaagcca cccaagatca catgttcgta ttatgtagct gaactggggt tggaacccaa 10440 gaaggtctga acacaggtca ctcactgctt ccttatttga taagatttat agtgacggaa 10500 agagtacatg atattgtccc aaagactaga gtgaatgtta aaaaatagac ttcttcctgc 10560 acccaggact cactgctaac agcagaaaaa aaaatacatg tgcatttcat taccaaaagg 10620 tgagtaattc ctttatttat atagagtcaa tgagaaatga gataagccaa ataagaaaat 10680 tgttcagata agtacgactt caagaaatcc tttcttttta atatttttat tgaaacattt 10740 ccattataac gataattttc tgccctacaa aatagagtat attgaatatg gtttaccttt 10800 gggtaaagaa ttatcattat caatatgaat tttcatactg tgctatgaga ccactgaccc 10860 atgttttcta agtccttctg tctagggagt tttttaactt ttctcttttt ttttcttttt 10920 gctgtcagct atcacctact gataacagtg tgttcgctgc ttgctttcag caagtcattt 10980 tccctagatc caatgcattc cttctgggtt aaacaagatt tttagaacag tatctaaaat 11040 aagacagaca agattttttg tgagggtatt tgtaaatctc ctacagctgt aaaataatat 11100 ttaacaaaat aaggaatcta ataataggtt ttaatgcaac catacatcaa cggacaataa 11160 tttgatcata taaattgata ctgccatatt aatctcaaag tggcattcaa catcattctt 11220 aacagtgaaa gataagtttt cctgtaaaaa gcagaaaaaa agaatgccgt ctatggctac 11280 tattatttat catagttcag agagttttcc aatgcaaaac agcaaggaaa aaaagaaata 11340 gttattaaga aaattagaaa gtatagatat tggcagaaga aataacacag aaaataccct 11400 aaaaacataa ctaaaattct taaaagtata aagatagttt tttaatctaa taaaatagct 11460 aagtgtaatc aaagtaaatg gttttttaat atatgaatac tgtaataacc aaaaatgtag 11520 tgagaaaaaa agtcaaaaaa ctggtaaaat atatatatat ataaatagat gatcaaaata 11580 cttaacattt tactgaagaa tcaaagatac aattatgtta tgatccatta ttaataaaat 11640 tcttatattt atttataatt taatgtctat caaaaaatcc cattttttct gatcattcta 11700 attcctaaaa tgattctgat aagacatttt tttttttttt gagacagagt ctcctctgtc 11760 acccaggctg gagtgcagtg gcacaatctc agctcactgc aacctccacc tcctgggttc 11820 aagcaatttt tatgcctcag tcacccgagt agctgagact acaggtgccc actaccacac 11880 ctggctaact tttgtatttt tagtagagat ggggtttcac catgttgccc aggctggtct 11940 caaacttctg gcctcatgtg atccaactgc ctcagcttcc caaagtgctg ggattacagg 12000 tgtgaaccac catgcccagc caagacattt atttaaaata ggtgaaatta ctcaaaattt 12060 ttggaaaaaa agaataagat acattatcca gtattaaatt ttactgtaat taaatatgat 12120 ttggtttcta ttaaggcata agaaaaaaga ttaatgaagc aaatagaaaa ttcccagaca 12180 Página 71 aaataaataa aatacttgca tatatgatga tgacattttt taaaaataaa tcttgaaatg 12240 aggcagtttg tattcaaatt cccaactcca tctcatacac tgtgagtatt taaaccttct 12300 gagcactaac ttccccatct gtaaagtgat aatactgaca agattaatta aataatgtgt 12360 ataaagcagt acctggcctg tattacacat atggatatct gaatccaagt gaaaacgtca 12420 tgtaggcagt tggatgtgta agcctagagt tcagaggaga gtcaagtata agtgaccatc 12480 aggtgaccat tacagccact ggactccata aaatgatgac atgagatggc tcagaaagag 12540 atgaaaatag gaagatgagg ccgggagcaa tggctcacgc ctgtaatccc agcacttcag 12600 gaggctgagg tgggcagatc acctgaggtc aggagttcga ggccagcctg atcaacatgg 12660 agaaaccccg tctctactca aaatacaaaa ttagctggcg tagtggcaca tgcctgtaat 12720 tccagctgct caggagacca aagcaggaga atcacttgaa cccgggaggt ggaggttgtg 12780 gtgagccgag atcacaccat tgcactccag cctgggcaac aagagtgaaa ctccatctaa 12840 aaaaaaaaga aagaaagaaa gaaaaaggaa ataggaagat aaggtgtaag ccgtaagcct 12900 cttgaccctc aacattagtc tcctagtgat ttttcccacc tcttatttca cccccttcaa 12960 atcatgttag ccattttcta gatccatcac tataggcacg ttgtttcaac actttgtacc 13020 tcatttttct catctgtaca ataagcataa taatctaatg tgaagattaa atgaattaat 13080 aatgtacata tggaggtcag agcgatgcct ggcacaaggt agtgctaagt acctgcttac 13140 tattataatt atcattatta ttcaagtttc tcccagctca gaaggtgtga aattataagg 13200 tatgatctgt agatgtgtgc atgaaagaat cccttgttgc ctgtgtttat gtggatgtag 13260 atgtgtgtgt gttttggaga aggatgggga gtactatagc agtacaatac gagccacatg 13320 cataatttta aaattgtggt aaccacatta aaaaagtaaa aagcaacagg taaaattaac 13380 tgtagcaata cattttattt agcccaatat atctgaaatt tttattctac acaacataaa 13440 acttattagt gagatagttt atatcatttt tatactatct tcaaaatctg gtgtatattt 13500 tacacataca gcaatctact cttggacaag ccccacttca catgtcctgt atgcacttgg 13560 ggctagagac tatcacactg gacagcacag ctctagataa atggggagat cagaagccag 13620 acacatgata tgtctaaagg agatagctag aggagaataa tgaagaaaca gagcaaactt 13680 gattaaagat aaaggagaag gaagagaaat ttctgcaaat gaaagataac tgtgttttcc 13740 tttctcatga taaaacatgt attttatcat tcccctgtca aacagaatct tgattcatga 13800 tctacaagaa gagattgaga aacagtttga tgttaaagaa gatatcccag gcaggcacag 13860 ctacgcaaaa tacaataatt gggaaaaggt acagtaaaaa atgcctgtac ttttttttaa 13920 gttaccctta atatttattg tcattttgtt ttcttttatt ctaatttctc aaaattgatt 13980 ttgctcttaa gattgtggct tggactgaaa agatgatgga taagtatcct gaaatggtct 14040 ctcgtattaa aattggatct actgttgaag ataatccact atatgttctg aaggtaaaaa 14100 taactcaaga accactaatt cttattactg ttgaaaaaca tgaatttaaa agttactttg 14160 taacacaact aagctaattc tgagctaata catattatct ctgaaagaat atttaagctc 14220 tagacatcca ttaaagaata gaaatgacaa gcggttttgg tggaaccaag aaagtgtctg 14280 Página 72 gataaacatt tgtcagagat tgcacagtgg acaaacccaa acaaatattt catcccacag 14340 ctttattaca agagtccatg atgtctctgg tataaaaaaa accctcatcc cttaaaatgc 14400 agtgaaactg atgaatgaat gtcatgaagg gaatttaaat atcatagcat cataggactg 14460 tagaacagtg tgttaggcat ttcaaccatg gattgcttga gggttcccta tatcagagcc 14520 aacaatttcc actccattgc tgctggattt ttgcacatcc aaagatactg ctccctgaag 14580 cagccactta acaagtgaga agcccatcca catcccaaac ccccattcat tcattatctc 14640 caaccactca aaacaaacct gcactctctt caaaatgaca gccattcaag tatccagtac 14700 tatttccctt ccccactcca acacaacaca agatcttctc cattccaggg taaatatccc 14760 cagtttacac aaccagaaaa acaaaaggaa gtggcagaaa caaaagtgac tttataataa 14820 atttctcaga acacaggatg ttagtaataa aataaaaaca atggactaca aatttttttc 14880 aaaatcctac cagctgccct gacactagaa aaattttttg aaaaatatgc attgtaatag 14940 attatgaatt atgtatagac atttaaggat atgtcccatg gtcccttctg agaacaatat 15000 gtgcatacat ggttctcatt caacaataga caggggaaat aattgctttg agaatatgaa 15060 tgagttattg gtcaacaagg gatcaatgtg tgagtttgtt caaaacaata tctcaagttt 15120 acttttaaat agattgggga aaagaatgaa agaagaaagg ctatttttac ggattgtggc 15180 attcacgcac gagaatgggt ctccccagca ttctgccagt ggtttgtcta tcaggtaagt 15240 gaatcagaag actcccaatt ctcctttgac tgccaagtct ccagcacttc actaagtggc 15300 gacatctttc caaacacgca attccactta gctagaagag cccatacttg gtgctgtcag 15360 ggaagaaacg ctctgaattt tactcatcat tacagttttt atgaaattga caacttccct 15420 ccaaacaatt cttaaactca agctaagagt ttatgaaact cacacttttc ttgggctatc 15480 acatgaaagt ttttactgta gtcaagtatg gaaaatctga aacaaccttc acataaccta 15540 caaatgtaac ttttcttcaa tgagctcaaa acatagatat ttaattttaa ttcctcttta 15600 gataatacat tggccgcaca tgtacttgga attttaatat ttaagtttcc tttctgagtg 15660 aaaaataact cacttttttc tttttttttt ttttgagatg gagtctcact ctgtcaccca 15720 ggctggaatg cagtggtgca atctcgtctc actgcaacct ccgcctcctg ggttcaagca 15780 attctactac ctcagtctcc aaagtagctg gaactacagg catgcgccac catgcctggc 15840 taatttttgt atttttagta gagactggat tttgccatgt tggccaggct gttatcaaac 15900 tcctgatccc aagtaatctg tccccctcgg cctcccaaag tgctgggata acaggtatga 15960 gccaccacac tgggcctaca attcactttt ttaaaaggtt tatctagttt atatattcaa 16020 tattcctctc actctattgc caatgtattt tgactcctac catattttaa ttttctcttt 16080 ctgtcagctt ttgcacatgg cacagtggtg aaatatgtgt aacaatggtt ttctgggcat 16140 agatattttt ctagaaaaga atccaccagg aagtgacctg tagttacttt tgctctccca 16200 actgagggcc aagagctccc cctactcaac acataaagga atgcacatca caggtctaca 16260 aaaaatcttg tctccaattc agatgtacct agaaggactt cccaagagtg gtgagagaga 16320 ttttaggtag ctacagaaag tgcatgtgat tagagaaatt tcagtcagat atagaaaaaa 16380 Página 73 aaaagttgtt caatctctga attcttgggt attttattaa tacaattttt tatttaatcc 16440 tgcttataac tatctcacaa attctctcca atattttcat attcctgtgc ttacagactc 16500 tatctatatt tatgtaaaag atgtgagaga atcaattaaa aataagttgt attacaaatt 16560 ttccatttgg cttccaatct ttctatgaaa catatctctc atgctacatt tggaatgcta 16620 taagtctcga taattaaatg ctcctttaaa gactattcat ttccattaat gtcactagtc 16680 taaataagtt aggttttttt cccctttaaa ctatatggat tgtttatttt tgttcatttt 16740 agggaaaata tgcttgaaaa catgtgacct tgggaagtga ctcaagttat tactattata 16800 accacagctt tccacataat agctaaactt cataccaata gcttaatttt ttttcacctc 16860 cgacaggcaa ccaaaactta tgggagaaac aaaattatga ccaaactctt ggaccgaatg 16920 aatttttaca ttcttcctgt gttcaatgtt gatggatata tttggtcatg gacaaaggta 16980 ctgctctcta ctctcttgtt tgcatttaga tattatttgc tggctttaat acacaatgtt 17040 atgcattcag cttagggttt aggtaactag ttaattctaa ttcagaaaag tatatttttt 17100 aaaatctcag tttcaaatta agtatgattt cttggttgca taggtatcct tgaaataata 17160 taaaattttt gctgctgaag ctagttatgt gggaaaatga aataaagtag taattacaga 17220 ggaaatgtat gattgcatta tatgatatgg catatctagc taagaataaa gccaattaat 17280 tgattttaaa acaaaaacct ttgtatttca tcaattttga atagaatttg aggtagaatc 17340 attgtatcaa aaaaaataaa agagaggtac agatacctat ttgtcttttt acagtatatt 17400 ttattatcct gcttttgcta aataagaact ctcaggcaga cactgtcaca tcaaattatt 17460 ttctgcaaat aatgctccaa cagtaaaaat ttgacctgca ttatatctga atctatatat 17520 ggtgaacaag ctaatgaagt tataatttaa attatggtta atttcagaac accgttagtc 17580 atcttctaat actgtgaact aatcaacagt gtttaaaatt aactgaatta tttcatcaaa 17640 gcctaaggat ataatattaa aaaccatgat tctgaaaata ctacaaatta taagaaaaca 17700 atattttttt ctttttataa taaagggcct caagttaact agatagattt caaataaagt 17760 tgcagacacc tgcagagaga atttgaaatg atcaaattga aaaatgcaaa ctgatcttgt 17820 gtaaacactt acgtcattca atctggcaga accgcatgtg gagaaaaaat cgttccaaga 17880 accaaaactc caaatgcatc ggcactgacc tcaacaggaa ttttaatgct tcatggaact 17940 gtgagtagca gacttgctat caaggaaaat tgctataagg aatatttagg tcccaaactt 18000 aactaaaaca cctacttgtt cagtaaaaat agttatgctt tgagtgagtg ttaacttttg 18060 tatctataac atgaaagaca atcatcacta ccattgaggg atgtcttgct gtgtggaagg 18120 aaatgaggag gaagggactg tttatcaaac catctcttac ttactatatc tagtttgcta 18180 aaaattaagc acaatccaaa tgtataaaaa ttcagataat ctgaataaag acctcagatt 18240 cctctgcttc ctgatgtgag aaatgtcagt ggctaaaagc aacatacaga cagtttttca 18300 gatatttagt gaaaagagtc atctggagca aagaaagtga aaaagtttaa cagaaatacg 18360 atgataagca gaggcctgct acatcagacg atgctttagt tgctatacaa ctatgacttc 18420 atcactgcac actttcaagg agaaattacc attgccccaa tttatatatt tcttctgtgc 18480 Página 74 ctaattttgt tgaaaacatc acctgagctt ttaactgtat tctaccataa tgaacataga 18540 agagcagcag ctatctctaa ttgagagctt tctgctgaaa aaggctgaag aaacttgtgc 18600 ccagggaagg taattcacac cagcccccag cgcattagag ctggggttga attagaactg 18660 gagtgtatct ggctccaagt catggctgct tctgatttat tactcctgtg gccttgggaa 18720 aggacaagga agtaaacaag gcttagaata ttccagtggg ctaagtctgt tacaatctgg 18780 catgtgtgtg caatgttaat ctgtagtgac tatgatacaa gagacattga agcagccctg 18840 taaacatgag aggcaaaaac atttaaaaca ttctgtgaat ctataataca ttagaagagg 18900 caggagctat atggatgggg agcagactgt ggtctcatcc acctatgtct tctgcagcca 18960 ttcctaacac caatgaccca tgtgcagata actatcgggg ctctgcacca gagtccgaga 19020 aagagacgaa agctgtcact aatttcatta gaagccacct gaatgaaatc aaggtttaca 19080 tcaccttcca ttcctactcc cagatgctat tgtttcccta tggatataca tcaaaactgc 19140 cacctaacca tgaggacttg gtacgtagac aaaagtttgc acttcatgca tcgacaatac 19200 cattgacttt cagtctgttc ttcattaact tgggtatgtt gaaagaattt cacattttaa 19260 tgtcaaagaa aagaactaat gaaatttgcc ttgaagttaa aatcatgatc tttagattga 19320 tttttcattg ataaaagtat atagataata aattccttta atgtgattct caggaggaaa 19380 aaaaaatcag gaagaaatgt ctaggaaagg cataatagaa gtctattaca acacagctca 19440 ttgtggggtt taacatttac catgggttgt acggtaaaac catgcacgga aaaagcccaa 19500 tagaatagca aagacattta ctagtcctgc cccccagata tcagatttaa gaagatacat 19560 tgtattttta tcctgatcaa cttggaaatt atattctttt acaatccaaa gaagattata 19620 aatgtttgtg aagcttcttc actaagaata tgttatcttt ccaaaactat gatccattaa 19680 gcaccatttt gtttataaaa actgatttga taatgtgagc tttaaaaaaa aagtctgcat 19740 atgggttcca atgaatcaca ggaagtgaca gagtgaatgg gtgcatagag ggataaatat 19800 tttgaattgc tatagaagaa aataaataaa acagaaaaag tttagtggcc cagatcccat 19860 ggtgattggc aaatatagca ctttcagtaa tagctgtggt ccaaatactg cctcataaaa 19920 tattttaaaa tttttaagag gttacaattt tcattctgac ctcagtccat tgtatttagc 19980 acaacagcat ttaatgttaa ttggagcaga gacctgaatc agtcattaaa atcatctcca 20040 tatatacaac aaagaagaca taccagcaat atatggccca tagtcattta ttatccaatg 20100 taggtgataa tctgagggcg tgagttcaat taatgcatac caatgtacag cactgtgatt 20160 tcaatccact gttaggaaaa tgatattatg ggttaaaaaa aatacatatc cacaaaaaaa 20220 aaaaccactt tgagtaaaat gagagttctt gcatagcaac taaattgatt aagaaaaaaa 20280 ttatttattg gttatatacg ttatatgtat agtcttttaa aaatctttgt gagtgcaaat 20340 atgttagtaa ctatattcca ttaaaattca ttctgacaat cactctcata gcacaaaaca 20400 ctaacgtgta ttaaaaggtc atgacaaaat gccactctga aagagacacc ctaattaaca 20460 actattttaa aaagcggtca accacccttc ttcccttggt atgctgaagt cagatgagta 20520 gagaagatcc tgtagcaata tgagcctgtt agggaccaag gaatgtaaaa catggaagaa 20580 Página 75 aatggagaaa ctgtcagaag agacaattat ctgaagccaa aaaaattgac aggaaaaata 20640 atgtatattt tatattttag aagaaaggaa tgaggagaga gagagaaaga agagtagaaa 20700 cacaaaatga gatatggcat tactgtatat aatcgactgc atatttaagt cttttttttt 20760 tttttttttt tttttagacg gagtctcgct ctgtcaccag gctggagtgc agtggcgcaa 20820 tcttggctca ctacaacctc cgactccctg gttcaagcga ttctcctgcc tcagcctccc 20880 aagtagctga gactacaggc acatggcacc acccccagct aattttttgt atttttagta 20940 gagacggggt ttcaccatgc tagccaggat ggtctccatc tcctgacctc atgatctgcc 21000 cacctcagcc tccgcaagtg ctgggattac aggcgtgagc caccgtgccc ggccaagtct 21060 ttatacttac cacatatatt actgaaaata agtttctcgt ttaaccattt attttatttt 21120 gatcttcaaa tgccaaatac ctggtaaatt tgactttttt catccctagt aatttacata 21180 tttacatata tatatgtatg ggctttggtt ttgttaaaac caggaactga attccggctt 21240 caccagttgc aactaaccag gaaatagtac tgtccatctc atagggttgt tatgagtctt 21300 gaaactaaag atcaagggat aagcacagtg cctaacctgt aagactccat taaaaaattg 21360 catacataca taattacata ttccttggta tttacacagt atcctattat ttcactctaa 21420 ctttcctttc tctccaggcc aaagttgcaa agattggcac tgatgttcta tcaactcgat 21480 atgaaacccg ctacatctat ggcccaatag aatcaacaat ttgtaagtca ttcctcttat 21540 ttactgagcc cttttcccta attatttttt acaaatatta aagaaaatta tggaatttgc 21600 aatttaggtt agagcatctg gaattgctaa tttaaattct actttttaca ggatattctg 21660 aattatacgt gaatctaggg gatagattct gaccttttct tgggataaga tttttctaga 21720 aacaaattat actgaacttt tacagggtta caaggtcaac ggaagctatt aagtcaagac 21780 agatttacag tttactttat ctaccttcct gtttcccacc tgtaccacca acaatgttgt 21840 atccttccag gaactaatga gaattcactg gagtgagaaa aaaaaaaaaa ttagccaggc 21900 atggtgacct atgcctgtag tcccagtttc tctggaggct ggggtgggaa gatcatttgg 21960 gcctgggagg tcaagactgc catgagctgt gatcgtgcca cggcactcca gcctgggcaa 22020 cagagcaaga cctcatctaa aaaaaatcac ataaaagaaa ttagatggag tagagtctac 22080 atttttttta accatttaac tttaactgga ctctttctta cttgccttgt ctacatgtaa 22140 gtatggtctt ttccctagct gaaaaacagc taggatagga aaacagatag aaaatcagtt 22200 tcagctcctc tggtcgtgta aaacaagtta tctctccttc tcacttgctc cttctcacta 22260 tgttcagccg aaatctgtat ggtgaactag aagggagatc acaagactct agttctgtca 22320 cttttgtttc atactctcag caccatttct tactcttccc tatttttaaa tttatgttgt 22380 ctttgtgtgt ttttaagtta ttgacttgga tttcttggcc ttgattttct tgtctcttat 22440 tctatataaa agaaatcagt aatttttttt tctgtaaagg gccagatagt aaatagcttt 22500 ggctttgtgg aggtacagtt tctgttgcag gtactcaacc ggagaatcat agctcaaaaa 22560 cggccataga caataagtca gcaaatgggt gactatgtgc caataaaacc tcattcacag 22620 aaacaggagg ctgaccagga tttgccaact cccatacttt atactaaata atatctgcaa 22680 Página 76 atttttatgg agtctttaca agttaggcac tgtgcttacc ccttgatttt cacaatctca 22740 agcttcacaa caaccctatg aggtggggag tagtatttcc cagttattag taaccggcga 22800 agctggaact caatctcaga ttttaacaaa caaaagccct gatcctgacc actgcacata 22860 ctgtttgtgc atttggattt tgtagctgaa atatccagga ttttctattt gcaatgaaca 22920 gccaaaaaat ccatttgagt atcaccgaag acaattaact cagatcctgg gaagtgagac 22980 cactttctgc tcttacagca actcccacta agcttagttt gggaattatt tagtaaaaac 23040 taccttttct ccaaaccaag ttcaagcttc agttcttagt ctcaaaattt atacaaaatt 23100 ccccatgaaa cttctcaaaa gcaagaatta tgcttcagat ttcctcttag accctgtaac 23160 atatagtaca gtgcacggca tggaacaaca gcagaattag ttcccataaa cttgctcaat 23220 gataatggtg tcctggctta ttcaaaagaa gtgaatgtga gttgaaacca caacagtact 23280 ggacttgatt aagcctgcat cactctctag accaaatatc caacagtgtt tagcattaag 23340 actaccattt aacttttaaa aatttcatga acaacccttc caccaccaaa gatacactca 23400 tatttttatt acacttttag aatctgtgca ttaaaaaata catatgtgca tatgaattca 23460 ggattccttg caacaatttt acctgaccac agtttttaag tcactttcgt attccaagct 23520 gaaagtataa actttgaact gaaagtctac atcctcagca attgcgatgg aatttgaaaa 23580 tgccggaatc aacatataca gtttctagga cttacttatt agatgcttct ttggcagaac 23640 tggaaaatga ctaaaaaatg gacaagtccc tttcctcgag cacattcatt aacaatcacc 23700 tatcaaccag tcactgttaa ggtgctgaag aaaaagtgta gtgatacaga tgatccccag 23760 catccacata gatcttgcta caacctagcc atgctgggga ctcattacac atacaggtgg 23820 atgaccacaa gatttcaaaa tacatgttat gtacccagct atgtgagtgg acaaaaagta 23880 agcaaagtaa agaacaagaa gacagactag aagatcagtt taaaatggca gcccacttag 23940 tagatactaa taaatagcag ggccagattg gccacccaga caccacatga gagcaattcc 24000 tctaagcaag aaaaacccac agatagtctt agaggcaaag aacaaagcat tccaaacagg 24060 aacaaacttt gcaaaaggca attaaagcat caaataatta tccgtgtgtg tgtatccaca 24120 aaagtatgag aatacagagc tgtgcatagc attgcattaa gacctcttaa tgaacaaaaa 24180 tatatggtgt acctagctag caggctagca ctttggagct ttcagagata aatgagagga 24240 cttaggacac aataaactac tcttaaggaa gtcacattct aagtggaagg agcggagagc 24300 caaaactacc atagctccat gccatcatgt gtcactttca aaatggaaag atacagtcaa 24360 gagggattac tattctgttt aactgtgcag cattatttaa aatttttatt acattatact 24420 acaacatttt aaaggcattg agatttagaa agaattgcct ttgtcacgca gtgctgcagc 24480 agcttgataa acgatcaaga tttctagaac agactgcttt aataaagcat ctgatagaat 24540 gttaatcaaa catgcatgag aaacagggta gcaaagcagt tgacttggta agaataaaaa 24600 ataaaaatgt gattaaagtt tagtcattcc aataacctga ttgtcactta acatgtcccc 24660 agatttagga acagcatcta gcatttgtca gtgatttcct gtcttcgact tgatgaagac 24720 agaaaaaaaa ggactggggg agcatttttt aaactcaact tatggaggat ctctggcctt 24780 Página 77 tagaaaaaaa tatatatatg tttgctcttt gaacatgaga ggcaaacata tcagataagt 24840 taaaatcata aattttgaaa ccagggagaa acataggcaa tgatctattc catggttctc 24900 aagcctgact tcccattaga atcatcagga agctggccag gcctggtggc tcacttttgt 24960 aatcctagca ctttgggagg ctgaggaggg cggatcacaa ggtgaggagt ttgagaccag 25020 tctggccaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc tgggcgtaat 25080 ggtgggcacc tgtaatccca gctactcaga aggctgaggc aggagaatca cttgaaacca 25140 gaaggcggag gttgcagtga gccaagatca cgccactgca cttcagcctg ggtgaaagag 25200 caaaactcca tctcaaaaaa aaaaaaaaaa aagaatcatc aggaagcttt taaaatacat 25260 gaatgattat acccccagcc cccagagatt ctgatttcat cagtctgagg aggagctcgg 25320 cactcaattt ttttttaagt accttaagtg attctaagat gaaactaggg ttgagaatcg 25380 ctgatctaag caaaacttct catttataga ctgaaattca gatacagaaa tatttcatca 25440 ctttagggca gaagaaaaac aaaaatcagc attcaacacc agagttaaaa tggtatacct 25500 accactttgc cccaaagcag caatattgag atggcacaaa aaagtaaata gtaatgttta 25560 atgtgaaatg attatatttg catataaaca gcatatccaa tccttcatca tcttagaaat 25620 aactaaacat agtacctagt gagcaagaat agttatttga gttgataaga accaagattg 25680 cattagtaat aaaattcatc tgtgagtcac atcatgaatt aaaaagttaa tttcaaagta 25740 catttcttgt agcttccttt gtgtaccaaa attgctagat ctaccactga ttctcaaccc 25800 agtgctcttt ttccatattc tacatattct actttttcaa aatttacatt ctgaaaaaga 25860 aaagttaaga cttgtagttc ataacaccag atctctactt actaagagac attcaaactg 25920 atattacaga gaaaatattt cagtgtatgc ccatgtatct ctggcttcag ctcttgcttc 25980 taatataatt ttcacttagt attaatataa aagtacaggt tattatattg aatacattta 26040 aataatattt tttaaaacga tacaattttt cagaaaacac tgtatcaagt aagcaataaa 26100 tgcagcacac attaagtcac caacgtcact ttatatggat ccctttgggc tgaaatcaga 26160 tttctagttt ggtacggttt cattttgatt tgttctcatt gaatttgttg caaccaatat 26220 tgtgccttga aataagtagg aaatattttc ttaatgttga acatactcag aatatgctgt 26280 caacaaaaac aaaattatct tatagaactg agtaaagact tggtattggc tagtatatag 26340 agtggcacat aggtagcaca gtacaatgat taacaacatg aactctgaag acaccacctg 26400 ggcttgaatc ctgattcgac catctactag ctatgtgttt ttcagcaagt tgcttaatct 26460 ctctgagcct aggtttcttc ttcggtaaaa tggtaattgt tacttacatt tgggatagga 26520 attaattaaa tgagttaaca tgcataaagc acatagaagg gtacttggta tttagcaagt 26580 gattattact gtattttata aatgcataca catgttttag taggtacaca tggagataaa 26640 gaaaaggcta agtatcatgt taaacaaatt aagttctggc caggcacagt gatgcacacc 26700 tgtagtccca gctactcagg aggctgaggt ggaagtatca cttcagcctg ggacgtcgag 26760 gatacagtga gccatgatca tgccaccgca ctccagccaa ggtaacagag caagaccctg 26820 tcacatacac acacacacac acacacacac acacacatac acacacacac acacacaaat 26880 Página 78 tctatatttt tttctcaaag taaaaacttg caatgttgta tttactttat gacttgatat 26940 agttttgttt gcaaatttaa gatctagaag atatgaaatg tattctactt catagcatca 27000 cataattatg aaaaatcaaa ttccatatat tctcaatcac cactattaat cttaatgaca 27060 aactccacat aaagtaaatc tctcaaaata gaatagccat gccctttaac ccttggaaat 27120 cacagcagtt tactcgactg caaatagaga gctactgcaa ctaggaactg gccaagttta 27180 ttaaaatgtc taacatatcc taaattacaa gacataattc ctatttactt tacctccttt 27240 gctaccaagc ttgcatctta gtgtgatttc tttctcatga acttaaatcc aactagctaa 27300 aagtggcaat ctgtttgatc actgaagcca gtctctatat ttcagctcac gtgctccata 27360 aattacatgc aatatttgac cctgttaata acttcttgcc attcctttgg cttccttgac 27420 tttgaactct actggttctc ttcttcctcc tcctcctttt tttctactct cccactgact 27480 gcttctaaaa gtagacattt tccaaaaaat agggtacaat atatggatac ttcctcaggt 27540 tctctcctca ggtccctcct cttacttctg actctcctca tcaagaaata acctctatcc 27600 ccacaggctg gaatccctca tttgttacct agggcaccag gcaatcacct tttacccact 27660 aagtgaacca accagaccaa aatagcaatg caaaggcttt gaaaactata ttgtcagctg 27720 agcacggtgg ctcatgcctg taatcttagc actttgggag gccaaggtgg gaggatcacc 27780 tgagaacagg agtccgagac cagcctggcc aacatggtga aacccggtct ctactaaaaa 27840 tacaaaaatt agctaggtgt ggtggtacgc acctgtagtc ccagctactc aagaggccga 27900 ggcaggagaa ttgcttgaac ctggaaggca gaggttgcag tgagctgaaa tcgtaccact 27960 ccacttcagt ctgggcaaca aagtgagact ctatctcaaa aacaacaaca acaacaacaa 28020 caaaaaacca aagcaaaact gtctgggtgt ggtggcacat gcctgtaatc ccagcacttt 28080 gggaggccga ggtaggcaga ttgcctgagg tcaggagttc aagaccagcc tgaccaatat 28140 ggtgaaaccc tgtctctact aaaaatacaa aagttagcca ggtgtggtgg caggcgcctg 28200 tagagaggag aagcacttgg acctgggagg cagaggttgc agtgagccaa gattgtgtca 28260 ttgcattctc gcctgggtga cagagtgaga ctccatctca aaagaaaaaa aaaaatacta 28320 tattgtcatc agtatcacaa gacacaaaag taggccaggg cctgtttact aaacctgaac 28380 agggtgatta cctgctaaat tgaagattta agttacaatt tattatttaa tgtaatagct 28440 aaaatgtcca gaatataatc aaaaatcgct tgtaatacta aaaacaagaa aaattacagc 28500 ttgaatacaa aaagataatc cacagatgcc aacactgaga tgattgcagt ttcaaacatt 28560 ggaaaagaat ttcaaagttg ccatcattaa aaaaaaaatg cctcaacaaa caattacaga 28620 tggccttgaa acaaatgaag aaatggaaac tatcatcaaa gaaataaata taagatacaa 28680 aaaggaacca aatggaaacc atagaactag aaaatgtaat aacttgaaca acaaaaaaac 28740 tggaagggct taatagcaga ataaatatga cagagggaag aatcagtgaa cttaaagaca 28800 gagcaatata attcactcgc tctgaagaca gaaaataaac aaaaataaat aactaaacaa 28860 agcctcagga acaaatggca taataaaata tccaacattc atgtcatcgg tccaaggaaa 28920 agataaataa agggaacagg agctggaaaa aaaatgtttg aagaaataaa agctgaaata 28980 Página 79 tcctacattt gacaaagaca taaactaaca tagtcaagta gctgagtgaa acccaaacag 29040 gaataaccca gagaaactca catcaaagta catcataatt aaacttctga aaactagaca 29100 aagaaacaag tcgtaaaagg aatcagacag aaatgatcta gagttaaaaa cagttccagt 29160 gacagcagat ttttcatgtg aaaccatgga agtcaaaagg aagtgacatt ttctcaagtg 29220 ctgaatgaaa acacctatca accctaaatt caataaattc aatgtattgc aaaaatattc 29280 agaaatgaag gagggaataa gacattctca tacaaaggga aatcagcaga tgtgtgcccc 29340 gcacacctac tcttaatggc taaaagaacc ctctgaacaa gaaggaaata atcacagcaa 29400 aaggcttgga actgcagaga ggaaggaaga aaaatggatt cagtataaat aaataaatta 29460 aataatagac tatctttctc cacatgatga ttgaatcaaa aattgtaagt ctgtttgatg 29520 tgatgttcaa tgtatgtaga gaagtactca agacaattgt actttaaaag tgggaaggga 29580 aaaaggatct gaaaggaagt aaagtttcta cacctcactt gacatagtaa aatgtcaata 29640 ccattagact gtggtaagtt atgtatgtgt attatagtac ctggagcaac cattaagaaa 29700 actaagcaag tgagactata aatcaatcaa atggaatcct aaaaatgtca tgtaaccaag 29760 aggaaggtgt aaagcaagaa aaaaaagata aagggataaa aacagaaaga acaaaaaaaa 29820 aaaaagaaat aatggcatgt ttaagtcata tcaataattt acctacacgc actaattaaa 29880 gacacatggg cagaatgaat tttttaaatt ataattcaac aatatgctgt ttataagaaa 29940 ctcatttcca atataacaac acagataagt tgaaatgaga atgatggaaa agatatacta 30000 tgccatagga agaatagcta cattaagtat cagataaagt gaatttcaga gcaaagaaat 30060 ttgctagtga cagagacatt aacaatgata aaaggatcca tcccaccaag aaaataatga 30120 tcctaaatgt gtgcacacca atttcaccta tgatgtctat gccaataatt taaacattca 30180 tttttccaag ctctttcttg aatgtctgat tgatgttaaa cgtatcactt tgtcttcctt 30240 tgccttttct ttttcccatc ccaatgctct ctgagttccc atttaacagt atgttttttc 30300 cagctaccca gattgaaaca tcaatcattt ttatgaaatc ccaatgtttc ttatgtagaa 30360 tccctcagtt gtttctaatg tggtgactct accctagtca ggctttcatt tcacactact 30420 tcataactgg tttctattct tttcaatcca gattaacaaa cctaaagtac tagaaggcct 30480 ccaaaagaaa atctaaacac ctagtcccga ttcacaaggt tttccaagct ttactcacaa 30540 actctcactg ctccctttgc tctggtccag ctggatctcg ttggtttcta acaatgcctc 30600 catgcttttc tatccttgta gttcactggc tagaattcct ttcttccatc tccagctgaa 30660 aacacactag cctttcttca aggctctcct ccaataccat ctcctccatc atgaaggcag 30720 tatttgagct ggcactgggc atgaaaggcc atactcctca tcaagaataa tctctttttt 30780 cttttaaatc ttggtaaaat attgtacctt ttctatggta cttagcatat tctgctctgc 30840 ctctattgac ttataccttg acttctgcct cctaaattgt aagttactga agacaccagt 30900 ggcatcttct gcatttttgt accctgcaac aattactctc cccagtgcca agaaatgtgt 30960 cttgtaaata ttaaaggttt aataaatatt tggtgaccaa tttaagagcc aacactatct 31020 cttcatcaaa atatcccttc tctctttcat cgcagctttg aattcttatc tttcaaattt 31080 Página 80 ttcagatctt tcaaactgtt attattagtt aaactcatta cttgtcctag aacataaatg 31140 ccttcacata caaaaaaaac cttttatatc acataaagca aaatgtgagc acataaatgc 31200 aattatgata tgtatatgca cttgtatatg tatatagcct ctagatgtga gttatatgta 31260 tataaccttt agatgtgtgt ttatatttcc aatgttttta ccaaaaaata gaaccttgag 31320 ttaaatttca taaaagttga catggaaatt ttgaattagg agattaaata tgtctttaaa 31380 ataactaaat tacattttct tggtcttttg actatgaaat agtttaccct agcaacatga 31440 aaaacaagag acctaagcta ttagaagaaa tgcaattcta tgtatcttgt gtgtatagtt 31500 tttccctggt ggttttcaac gaccagtgac tccttagctg gtttcctcag ctgctagcac 31560 ttgctctggg tacttgtcct caacacgtcc atctgcaaca atgtgtgcct aggaaataaa 31620 ctcaacttac tactcaccca accaaaatgt aattttttaa acgcagcaca cactgggtgg 31680 attccaaagt catgattatg ctttactatg cactctgtac tattcagacc actactctca 31740 ttcattactg caattaactg cacacataac tattttttat tgctaattat acaccactga 31800 tttccacttt aaaaaaacat tagcatttgt ctctaattaa atatttactg cttgtgtttt 31860 acagacccga tatcaggttc ttctttagac tgggcttatg acctgggcat caaacacaca 31920 tttgcctttg agctccgaga taaaggcaaa tttggttttc tccttccaga atcccggata 31980 aagccaacgt gcagagagac catgctagct gtcaaattta ttgccaagta tatcctcaag 32040 catacttcct aaagaactgc cctctgtttg gaataagcca attaatcctt ttttgtgcct 32100 ttcatcagaa agtcaatctt cagttatccc caaatgcagc ttctatttca cctgaatcct 32160 tctcttgctc atttaagtcc catgttactg ctgtttgctt ttacttactt tcagtagcac 32220 cataacgaag tagctttaag tgaaaccttt taactacctt tctttgctcc aagtgaagtt 32280 tggacccagc agaaagcatt attttgaaag gtgatataca gtggggcaca gaaaacaaat 32340 gaaaaccttc agtttctcac agattttcac catgtggctt catcaattta tgtgctaata 32400 caataaaata aaatgcactt aatgctttaa aattcatctt tttatgataa actatattct 32460 ctgtatttct ctatagcatt aataatcaat attaatgcca ttcattcagt ctgttaataa 32520 gaaataatat cttcaatttt caaaaacata atttgtctat ctttttctga tagaagtaga 32580 cattgtttat atcttcaaaa aagcaaaagg atgtcctagc aggaaataaa gtggttcata 32640 tagagatgaa tctcagtcct ttaaataacc gatccagttc tcatcagcat aatgtacatt 32700 aaattcaaaa tagtttaatt taacctgcca taatcagaag aaaccacctg ctaaaacatc 32760 tgtttgccgg tacagacaca gacaagacag tctggtcagc tgtgacccct gccctcctaa 32820 tggatagaaa ggaaacctgg aaacatactg taagttgagg acggaaagtc atgttgacca 32880 aaggcaatca gggtaacttg ctgcatttgt accatttata ctcctattat ttaagatagt 32940 attattggat agcttctccc caacaccaat acctcaatgt gtgatcaagt ggcaacagtg 33000 gcagtgtcta cattcccaga atccagacac agatgcccac cacaggactg actataattt 33060 gagggacaag tagagagttc cttgacttcc agtaaactta cttctcagaa caccccagac 33120 agttttcaac gactgggaaa g 33141 Página 81 <210> 9 <211> 65178 <212> DNA <213> Homo sapiens <400> 9 cgccgcgtcc cggcctcggg gactgtgccc cgtcccgagc ctggcgtccc caaaggaaag 60 gcagggctcc tcggacgctc cgcgtgcgcg ctggccctcc gctgccgccc tctgcaggga 120 gatttctcct atttcggact aggaagggaa gatacgctcc ggaagacccc ccgggcgtcc 180 atgcaaggag tctccgtagg acccctggag aagggcaccg gagcccccta gggcaggaga 240 tggaaaagcg ctcgccatgc gcggggtccc cggcccccgg tgcccccagc ccgcctgcca 300 ttcccgggcg cttagcagtc cggggtcccc aggtgcccgg caggtccctt cgggacctcg 360 agccgcccgc tgggcacacg ctgacgccgc tgtcgcttta cagaaattga gcgcagccga 420 ggcgggaccc gggcgcagag agcgataaag gaaaagcatg gtcgtgctct aatcattaca 480 gtctaaggga cgacacgtcg agacggcgcg cgcctctgcg tgcgtggaga tggcacaaag 540 gccgcgccgc ccccggcggc ccccgccctc gcagcgcgcg tggtcccggc ccggccggat 600 gttgacagcg tcgcctagca acgggaaatg gcggaaccgg gcggcgcggc gggccggtaa 660 gccgggccga ggggcagcgg gtcttggagt cgccaggccg cgctctccgt tcaccgctcc 720 aggtggcccc cgcgtcggct cctgcctcgc cccttcgcct ccactccccc ttcctctcgc 780 ctgtgtccct tctctcgcca ttttgctggc ctttcccgtc cactgcgttc agcccctcac 840 ccccccgcca acccttctca cttctcccct cctgtccctt tgtcctctct cggcctccct 900 ctttccccta ctccaagcgc gcgactccct ctaaaacccg ggaccgctca ctctgcagtc 960 accatggcaa ccactctgcg tggcggtccc tgcgcgcagt cctcctaaga gtagagggct 1020 ctgcagggcg cggggctgtt ggataccgcc cctgaccttg ctccggggcc actcgctgtg 1080 gccggagacc agcccggccc cgcgcctccc tcctgcaagg acagatcccc tctcgcaggc 1140 ttgggggtga cccgcgatgg gaggggtccc tgcggttagg cggcccgcga tagtccgcgg 1200 tcaccgtcct ggggcctggg tggaagcact gagcgcgcac agggagggcg gctgagtgaa 1260 gatccctgcc accgggcctc tgctcgctta ggctctgttt aaaaggatag aaacgattgg 1320 aaagagtttg gcctttttac cttagacaca tcggtattgt ttcatttttt taaaggtggg 1380 tctgtatgta ttgacatgga aagactaaag gtattattaa taaaacgata ggcataaatg 1440 taaaagggta ggtatactat gatctctaat tcagggtgtg tgtgtgtgtt taaaacatag 1500 aaaaatgttg aaagaatgtg gtcctaaatg ttatcaatga ttatcttggg aaggaaaggg 1560 aagatcacag ggaactgtca ctgtctgtct ctttgaacat atctatattc ctttgacaga 1620 taaaaatagc ttgaatcttt aattttttaa aaaagatata catatatata tatatatata 1680 tatattcctg tgctacgtaa atcgtggaga aactcagagt ccccagaaca cttactctga 1740 tcgcgctact ttctctacgt tgtatttctt ttccccagtt ttgtcccaga cacaagttat 1800 atttgaggtg acttttctgg ggtgatctaa tcctgctgtt ccttcgatgt tttaataatt 1860 Página 82

P201430887 ES 2 553 786 A1 09-06-2014 atatttttca ttcattcatg gagctttgct tttgtggcat ctccgccacc tgacaggcat 1920   gatatagtgc tatggttcct gacaaacagg acaaagacgt gacaacagcc tgggggtggc 1980 agagaagtaa caagtaaata aacagatgtg cagaattcag gaggggataa ggaccaagaa 2040 aaagaaagct gttgcttgaa actgttcaat tgtttctcta aaaccaggtc ccatccggaa 2100 gatggatcgg cttctgaggg agagaaggaa gggaataatg aaagccacat ggtaaaattc 2160 cctatgggca gttattccgg gcttatattt actaggaatt aaagagaatc agagtacggg 2220 cactgtggct cacgcctgta atcccaacac tttgggaggc caaggcaggt ggatcacatg 2280 aggttaggag tttgagacaa gcctggccaa catggtaaaa ccccatctct actaaaaata 2340 taaaaattag ccgggcgtgg tggtgcgcac atgtagtccc agctactcgg gaggctgagg 2400 caggacagtg gcttgaactc gggagacaga ggttgcagtg agccaagatc acaccattgc 2460 actccagcct gggtgaccag tgaaactcta tctcaaaaat aaataaatag gccgggcacg 2520 gtgactcacg cctgtaattc cagcactttg ggaggccgag gcaggcagat cacgaggtca 2580 aaagatcgag actatcctgg ccaacatggt gaaaccctgt ctctactaaa aatacaaaaa 2640 tttgccaggc atggtggttc acgcctgtag tcccagctac tcgggaggct gaggcaggag 2700 aatggcttga acctgggaga tggaggttgc agtgagccga gattgtgcca ctgcactcag 2760 cctggcgaca gagcgagact ccatctcaaa aaatagataa ataaaattaa attaaaaata 2820 aataaataaa gagaattagg acttggtcaa gtatattgta tgatgacatt atcttgcacc 2880 agaacaaact caattcagtt gaagagagac tcattttctt cctaccccat tctacagtgt 2940 cagtgattag tcagggatgc aaaggatgtc caactttggg ttgccctgag tttttcggaa 3000 ctcatttcct gtaacaaagg atgcaaaaat gattatgaaa agcagagagg gccaggcatg 3060 gtggctcacg cctgtggtcc cggcactttg ggaggctgag gcggatggat ctcttgaggc 3120 caggaattca agaccagcct ggccaacatg gtgaaacccc atccctacta aaaatggaaa 3180 aattaactgg gcatggtggt acacacctgt agtcccagct acttgggagg ctgaagcagg 3240 agaatcgctt gaacccagga ggtggaagtt gcagtgagcc gagatcacgc caccgcactc 3300 cagcctgggc agcagagtga gcccctgtca caaaaaaaaa taaaaaaaga aagaacagat 3360 aaactgaagc atgaaacatg attttttttt tttttgagac agagtctcac tctgtctcca 3420 ggctgaagtt cagtggcacg atctcagctc actgcaacct ctgccttccg agtttaagca 3480 attctcctgc cccagccttc taagtagctg ggattacagg tgtgcaccac catacccagc 3540 taatttttgt atttttagta gagacggggt ttcaccatgt tggtcaggat ggtctcaatc 3600 tcctgacctc gtgatctgcc tgcctcagcc tcccaaagtg aaacatgatc tcttagtgat 3660 gctgagaagg gtataaatgc agttttccca ttgatataat tacactataa agaataaaac 3720 ctcacaaggt cctttatact ttgtttcctg atttttttcc tgccacacct ttacaggtgt 3780 caccaccaga gaaggatgat ggccagaaag gtgaagaagc tgtcggtagc acagagcatc 3840 ctgaggaagt cacaacccaa gcggaagctg caattgaaga gggggaggtg gagacagaag 3900 gggaagcagc agtggaaggg gaagaggagg ctgtgtccta tggagatgct gaaagcgaag 3960 Página 83

P201430887 ES 2 553 786 A1 09-06-2014 aggaatatta ctatacagaa acttcatccc cggaagggca aatcagtgct gcagatacga 4020   cttacccgta tttcagtcct cctcaggaac tgcctggaga ggaggcatac gatagtgtta 4080 gcggggaggc tggtctccaa ggcttccagc aagaggccac cggtccacca gaatccagag 4140 aaaggagggt cacctcccca gagccatccc acggagtctt aggcccgtcg gagcaaatgg 4200 gccaggtcac ctctgggcca gcagtgggca gattggtgag tagccctgac ttctgttttg 4260 tgccagtgtc gcacggccca cggggtttgt caccctatgt gaggaacttg ggaatacatt 4320 ataaatacaa attgcaatcc ctgttagaaa tgtcttagca aggctgggtg cggtggctca 4380 cgcctgtaat cccagcactt tgggaggcga aggtgggtgg gtcacctgag gtcaggagtt 4440 cgagaccagc ctggccaacg tggtgaaatc ctgtctctac taaatatgca aaaattaggc 4500 aggcgtggtg gcgcacgcct gtaatcccag ctactcagga ggctgaggtg ggagaattgc 4560 ttgaacccga gaggcggagg ctgcagtgag ccaagatccc accattgcac tatagcctgg 4620 gcaacagagt gagaccttgt ctcaaaaaaa aaaaaaaaaa gaaaagaaat ttcttagcaa 4680 gcttaggtct caggattcac ggtcaaatgc tgagagatcc tggactctgc ttcagtctgc 4740 ccaagcccaa ggctgggggc ctccatagcc gccatccacg taagggcatc caagttccca 4800 ggcttccaga gcagcattgt ccaatacggt ccatcagtca catgtggcta cagagagctc 4860 tccaaatgtg actagcgagc tggaggaatg gagcttttaa ctgtttaaga ttctaatttc 4920 catttaaata gccacctgtt gccagtggct gccataatga atagtgcagt tctagataaa 4980 aacaatgaca atagctgcgt tcttatattt tttcatcaat tttctttaaa caatcacaaa 5040 gttacagaaa aaaatggagt acaataaaaa ggatctttta ttttcttaaa cactggagag 5100 tgggttgcgg atctggtcac caaagccttc gaacgcttct gtatgtttcc cacaaacagc 5160 tgggacacaa ccatcaaaat ctagaaattg ggtcgggcat ggtggtgcac gcctgtaatc 5220 ccagcacttc gggaggccaa ggcgggtgga tcacttgagg ccaggagttc gataccagcc 5280 tggccaacat ggtgaaaccc catctctact aaaaatacaa aaattagctg gacgtggtgg 5340 tgcacacctg taatcccagc tactcgggag gctgaggcag gagaatcact tgaactggag 5400 aggcaggggt tgccgtcagc cgagatcgca cccctgtact cctgcatggg cgacagagcg 5460 agactctgtc tcaaaaaaaa aaaaaaattc tggaaattgc cttgctccat ttccaaggaa 5520 tgctcaggcc tcattcaggg ttcaccaaat gtcccaatga tgtcttttgt agcaaagaga 5580 ttcagttcag aatcaaatgt tgccttgagt gctcatattt ctgtagtctc ctcagtcttt 5640 ccttgacaac cttgaccctt gtgaaggtca taggccagct gtcttgtaga gcgcccctca 5700 gcctggattt gccccgtgtt tcctcatgat ggggttaggg tcatgaggct ttagtgggac 5760 tatcacggaa gcgacgtggg gctctcagtg cgtcccacca gggatgcagg attccagctt 5820 ccaccattcc tgatgatgtt cacttctgtc accaaattta aaagcaccaa gattcttcat 5880 tgtgaagcga ccttttactc ctttatactt aatgaagatt ttgtgggaag gtgctttttt 5940 cttttttggt ttaagatagg aaggcgaata ctatttagaa tgggaaaaaa attgcaacag 6000 attccaacca gttattgagg acttcttata tttgcttaca aacgtataca ggtgttatac 6060 Página 84

P201430887 ES 2 553 786 A1 09-06-2014 aacttttggc agatttatcc ctaagtattt ctcttttttt tgagatgtag tctcgctctg 6120   tcacccaggc tggagtgcag tggcatgatc ttggttcaca gcaacctctg cctcccgggt 6180 tcaagcaatt ctcctgcctc agcctcccaa gtagctggga ctacaggcac acaccaccac 6240 acctggctaa aattcggtat ttttagtaga gatggggttt caccatgttg gccaggctgg 6300 tctcgaactc ctgcccacaa atgatctgcc tgccgcagct tcccaaagtg ttgggattac 6360 aggtgtgagc catcgctcct gcccagtatt tcacattttt gatgccatta taaatggttt 6420 ccaattgtct gtggctagca tatagaaata caattggttt ttgtatactc acctgatatt 6480 ctgccacgtt gctaaagtcc ctcactagtt agactagctt gtttgtagaa tcggtaggct 6540 ttttcacaaa gataatcatc tcatctgaga aaaaagacag ttaacttctt cctttcccat 6600 ccagatgcct tttctttctt tttcttgcct gattgcattg gctagaaccg ccagcaccat 6660 gttgaataga agcggtgaga gcagacctct tgtcttgccc tgatcttaca ggaaaagcat 6720 cagtctttga ctgtaaagtg ccatgtttgc tgtgggtgtt gcagatgccc tttatcaggt 6780 taaggaagtt cccttgtatt ctcggtttgt tgtatgttgt tgggttgttt tttttttttt 6840 aatcataaaa gggtattggg ttttgtcaaa tccttttctg tgtctgttaa gaagactgta 6900 ttttcctttt tagttagttg atttggtaga ttacattgat tgattttcag atgttcaagc 6960 aaccccgcat tctgagataa acacagggag ccactttgga gtgatgtgaa tgtcggttcc 7020 tctttaaact cttggtttat ttatattctt acatctgcat agactcaggg ctctccatgt 7080 gattcactgg gttataaccc attactgtca ttatgtattt tgatgctcag tttggccagt 7140 gagggcccat ttaaaccagc ctttgtgtga tcggacgcac ctccatcctt ctttgagggc 7200 tttcttgctt tctgccatag actgcccagc cttagaatca gacatttctc caggagccct 7260 gtttctgtta gtggaaaata gaatttagaa gttatcactt gggtgctggg gtcctcattg 7320 atgctggggt gtcactgtcc ccaggacctc tcagcggcag gagatagggc ctgtgtgcgt 7380 gtactgtacg tacttccccc acatttatac atacaccatg tacacagaca ttcgctcaca 7440 tctatattta ttggaacaca cccctgcggc cggccttggc tcacacccct gcggccggcc 7500 ttggctcaca acagaacctc taattccatc tcacctccat aaggagtccc tcctggtttt 7560 ctcctcttcc tttttttttt tttttttttt gaaacagagt cttgcccagg tagctgggac 7620 tgcaagcact caccatcacg cccggctaat ttttgtattt tttgtacaag ggggcgtctt 7680 accatgatac ccaggctggt ctcgaactcc tgggctcagt caatcctccc tcctcaacct 7740 cccaaagtgc tgggattaca ggcatgagcc accacgcccg gcctcctctt ccatatttgt 7800 agctcctttc tccaacaggg agaagcctgg ccccatgatc cttactgtat tcactgatgt 7860 ggtcaatcct cctggatgta acctgtctcc cacttttact gccttggctg ccccctactc 7920 ccagcatacc ttaggtttca attgttctgc gaggggagat gggagtatgg aagggaggca 7980 gggaaagagg atgctttata cttcttagca ctgactatgg gatagacact gttctgtgtt 8040 gtcttagaat cctgacaacc ctacgaggta ggaactatga ttgtgcccat tgtacagatg 8100 aggaaactga gaggtgcaag gtcattgcat agtcacccag ctgttgcggc aaacggtagc 8160 Página 85

P201430887 ES 2 553 786 A1 09-06-2014 tcttgcttca aagccaccgt tctgaaccac aaggcaccca tccctcctac tcccctaccc 8220   tgggaaaccc gaaagagttt ctaaaagtca ctttggagaa cagcatgatt cagtatttgg 8280 tgagccctaa ttaagtttta tgatcacaag tgacaaatat aaaaccaaaa ccaaaatctt 8340 attttaagaa tttatcaaca acaacaggcc aggcctagtg gctcatggct gtgatcccag 8400 cactttggga ggccgatgca ggcggatcac ttgaggccag gagttcgaga ccagcttaac 8460 caacatggcg agaccccatc tctactaaaa atacaaaaat tagccgggtg tgttggtgca 8520 cacctgtagt cccagctact taggaggctg aggcacaaga atcgcttgag cttgggagtc 8580 agagattgca tgagccaaga tcatgccact gcactccagc ctgggagaca gagcgagacc 8640 ccatctcaaa aacaaaacaa aacaaacaaa caaaaaaaaa aatatatata tatatatata 8700 tatctcaaca acagcaaaac cagtgtcttc acctttgttt aagtgaagtc taggtcactt 8760 gttgctctgt aaacccgatt ttcatccttg ggcctagttt ctagaaaata cactgggaag 8820 tagttttcaa atatgattga agaaagggca gggacagccc ctgagcgagc cttgcttccc 8880 acctcccact ggctctcagt ctttgggaca gtgtgagtgg agcttgtgtc cagttgtgca 8940 cacggacacc cggaaacctc tcattaggag aagccactgc tgcgcaccct ggagatgggt 9000 tttgaccctg ggctcccgtt aatgttgttg tggctccaga tgcctcagaa ataacttcca 9060 gagtcaacac catctgcgga agtgccgtga gacggtgcat gggctggaga cagagacagc 9120 cggcgccgaa catacctggg gctgcccgtg caaactgggg caagcccttc agcctccatg 9180 tggctgcttt actatggaga acagaaatga ctagaacctg acttgtgggg ttatggcgag 9240 ggtggcatga gatgagcttt gtaacaatgt gttgtttatg ggcagcaaaa ccctgactca 9300 ttgtctgggt tactaatatc caagagttca tcatcagcga taattattgt caatagtcgt 9360 aactgcaaaa gtctctttta aagctaaaat ggatgccggg cacagtggct gtaatcccaa 9420 cactttgcga ggccgaggcg ggtggatcac ttgaggtcag gagttcgaga ccggcctggg 9480 taacatggca aaaccccgtc tctactaaaa gtgcaaaaat tagccaggtg tggtggcagg 9540 tgcctgtaat cccagctact caggaggctg aggcaagaga atcacttgaa cccaggaggc 9600 ggagtttgca gtgagccgag atggtgccac tgcactccag cctgggcgac agagcgagag 9660 tccatctcaa aaacaacaac aactacaaaa aacgctgaaa aacagagctg gggaaaggca 9720 ttaaggggag ggcttctcat aacaaaaact atcacaaaag actctgcaaa ccccacaatg 9780 ttgcacaaag atcatcataa cctttcaaaa aaaaaaaaaa cacttctgct aggacagctg 9840 ccagcaactg cctgtcgaaa cttggactga tgccaccctg ttattgatcc ttacagccaa 9900 ggagaattat cgcaaaacaa ttatgtaatc ctcctcattt ttcctgtgtc aactttcatc 9960 ttcctttacc tccccaaata caaacataat ttactatgac acccgtattc ccattgcaat 10020 gccctatccc caaataaatg tcattttcct ttacagaacc tctctctgtt tgttatttag 10080 gatgatacat tgctcaaaat ttaacatgat tgttaaagta ataggaaatc acttggatat 10140 aaaaatcatc atttgacttt tgcaaatgtc caaaatggaa aacatctaac tctcccccgc 10200 ccagggaatt cagaagtggt tcccccagct cacacctgta atcccagcac tttgggaggc 10260 Página 86

P201430887 ES 2 553 786 A1 09-06-2014 caaagcggaa aggctgaatg aggccaggaa tttgagacca gcctaggaat catagcaaga 10320   ccctacctct aagtaaaata ttaaaaaatt agaccagtgt ggtggtgtgc acctgtaatc 10380 ccagctactc tggaggctaa ggagggagga tcaccggagc ccagaagttg ggggttgcag 10440 tgagctatga ttgcagcact gcacgccagt ctaggtggca gagtgagacc cttactcaat 10500 aataataata ataataataa taaaagagtg gtttctgcgt gtctgcatct gtagctaagt 10560 gtaaacaccc aggcacgaga atgcatgggt cctgggatct tttgctccca catgctgagc 10620 gcctcgagga tgggaaacca caactctgag caccctcttc atgaaagcat gcggaaaagc 10680 ctcggctcct ggccagggtc tcccaagagg actgtttcct cttctctcct ttcaaaccag 10740 ccccctttag ggaaatttca ataagaaaat gtcttccctt cataaaaaca cctggctcga 10800 ttttaacttt atttatttat ttatttttga gaaggggtct tgctctgttg cccaggctgg 10860 agtgcagtgc tgtgatctct gctcactgca acctctgcct cccgggttca agcaattctc 10920 cctcctcagc ctcccaagta gctgggatta caggtgcccg ccaccgcacc cagctaattt 10980 ttgtatttct ggtagagacg gggtttcgcc atgttggcca ggctggtctc gaactcctgg 11040 cctcaagcga tccacccgcc ttggcctccc aaagtgctgg gagttacagg catgagccac 11100 gtgcccggcc aggtttttta aaaaacacac aggtgactat attttgagtc tgacaacttt 11160 cacaaatgta atgagttaaa attgaataac ttctcagtgg caattaagcc ctgttgactt 11220 agttttggtt gttcttgcca tagacaggat ccacagagga gccccagggg caggtgctcc 11280 caatgggcgt ccagcaccgc ttccggctga gccacgggag cgacatcgag tcctcagacc 11340 tggaggagtt cgtctcgcag gagccaggtg ccacccacct gctgaggtca ccctgccctg 11400 gcgatgagcc acctgcacag gcccttctgt gcaagggatg ccactcgttt gtcatccgtt 11460 acctgtttcc tgagtggctg tgagctgaaa gagaaaaatc ttattaacag atatggataa 11520 catttattgg gcatttactg ttttatctca tttaatccta acagtgaccg atgaagtagg 11580 aatccttctc catttaacag acaggttccc taaggccatt aaggaactgg tccgattaag 11640 tgacagaacg cggccttcac caagattcag tgacgcccag ccccatcccc tgacagccat 11700 ttctcacggg ctcctggtct cagagcgaga cgtgccgtga cagcaacccc aggcctgaat 11760 ctgtctgctg gctttcaaag gctttccaga acccctgtct tcttacgtag tcccagtatc 11820 ccagtgttgt ggacgtggga gggcagatca ggcagttgca aattccctgt ggtaccgacc 11880 tgcagccggt ccaaaccttt cattacttgc aaatgacatg aaaacagcac gtgtctaaat 11940 tagtaaaaaa acaagccggg cgcggtggct cacgcctgga atcccagcca aggccggtgg 12000 atcacctgag gtcaggtgtt cgagaccagt ctggccaaca tggtgaaacc cctgtctcta 12060 ctaaaaatac aaaaattacc gggcgtggtg gcgggtgcct gtaatcccca gctgctcggg 12120 aggctgaggc aggagaatcg cttgaacccc ggaggtggag gttgcagtga gccgagatca 12180 cgccactgca ctccagcctg ggcaacagag caagactctg tctggggata aaaaatattg 12240 tatccaatcc actagttaag tggccacctt tctgttcact ctttatgtgt aaagaaagcc 12300 tctcaaaaat aatttccttc ctgcctacct ttaaaacggg acgctttctc tgggatgcat 12360 Página 87

P201430887 ES 2 553 786 A1 09-06-2014 tgagtcaggg aatagaagat ggggtgaatg atgtttctga cccacagacc gttgggatgc 12420   ttttgctgtc actttcccat catgctgcat gaggcatgac agcagctgtg ccattgatgc 12480 cccagaatag aatcactgag gcttctctcc agcagctcct caatggtgtc gctgtctctc 12540 cccccagtga tccccccagg ggtgcccgat gcccacccca gggaaggaga cctgccagtg 12600 ttccaggacc agatccagca gcccagcacc gaggaggggg ccatggcaga gagagtggag 12660 tccgagggga gtgacgagga agcagaagac gaagggtccc agctggtggt tttggaccca 12720 gaccacgtaa ggaagccttc ccaggttttg cttttgccta catggatggc gaatgactca 12780 ggcccctttc tctgcctgca ctgtctccca ctcctgaccc taaatgctgt acttgtatct 12840 cgcctgttca ctgcaccgtt tattggcact gattgacctg cctcttcgta gggtactctc 12900 ctctgaggtt ggtataggtg aggcctgtgt ttctcaaccc cggaaccact gccccgtggg 12960 gccgggtcat tctgtgctgt gccttgcatg gtgtggaaca gcatccccga gctccccctg 13020 ctacatgcca ggagcaccac ccccccgcct tggttgtgat catcaaaaat gtctccaggc 13080 tggacgtggt agctcatgcc tgtaatccca gcactttggg aggccaaggt ctgtggatca 13140 cctgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccccat ctctactaaa 13200 aatacaaaaa aaaaaaaaaa ttagctgggc atggtggtga gcacctgtaa tccctgttac 13260 tcaggaggct gaggcaggag aatcgcttaa acccaagagg cggaggttgc atgcagacag 13320 ccaagatggc accagtgcac tccagcctgg gcaataagag cgaaactctg tctcaaaaaa 13380 aaaaaaaaaa aaatgtctcc agtcattgcc aaatgttggc ggtgtggggc ccatcttcgc 13440 agccactgcc ttgagggcac caattggatc gcagctccct gccccaccca ctggcaaggg 13500 gaaaaggcag atgttgattt catttaccca tcaggacagc tgcagagctc caggaactgc 13560 cggaaggagc tgggggctgc acagggaggt tctctcccca gaccactgct ccaccccacc 13620 ctctggcccc agctcaccat cattttgcca aaatatgcac tcagttctct gcaagtgcct 13680 cagatgagac catgaggtgc ctttaatttg tggcttccag agtaagaatc ccaagcagaa 13740 gcagggagca ctccacacgg aagtcgtctc tggcccaccg gagggagacc tgtggccacc 13800 tgggctgagc cctgggtcgg gcaggagggt aaccagaaag gtaaccacct gtggttttcc 13860 attgttctag cccctgatgg taagattcca ggctgccctg aagaactacc tgaaccgaca 13920 gatcgaaaag ttgaagctgg acctccaaga gctggtgtgt atccgtccag tctcccaccc 13980 tggtcggatg cctgcgtcct ggtgaccctg tttctctctt tggtccaggt tgtggctacc 14040 aagcagagcc gagcccagcg gcaggagctg ggggtgaatc tctatgaggt gcagcagcac 14100 ctggtacacc tgcagaagct gctggagaag agtcacgacc gccacgcaat ggcctcgagc 14160 gagcgcaggc agaaggagga ggagctgcag gccgcccgcg ctctctacac caagacctgc 14220 gcagccgcca acgaggagcg caaaaagtgt aaggcaaccc ggcagcccca cacgccatcc 14280 ggtcctggag ggtttcccag gggtgtctcc atgtaccatg gccaggcatc tagaaaagta 14340 agatgtgtgt gcatcctgga ggggttccca ccctttttag gaggggaagg cacataaatc 14400 aaatgtcttt ttgttgttgt ttttttgaga tggagtctca ctctgtcacc caggctggag 14460 Página 88

P201430887 ES 2 553 786 A1 09-06-2014 tgcaatggcg cgatcttggc tcactgcaac ctcccccttc cgggatcaag ccagtctcct 14520   ggctgagcct cccaagtagc tggtattaca ggcacctgcc accatgcctg gctatttttt 14580 gtatttttag tagagacggg gtttcaccat gttggccagg ctggtctcga actcctgacc 14640 tcaggtgatt cgcctgcctc ggcctcccaa aatgctggga ttacaggcat gagacactgc 14700 acccggttat aaatatgtta aatggcacct gtcaggacaa agcagcaaat gctgaagctg 14760 ctaacagcca gagcgtagag attcaaaact gggagagatg ggtgagctgc agaggtccca 14820 ggatagatga gaccaggagg cgagagcaga ccgggggtga tggagggttt caatagatgc 14880 gaatgcgagg gtgaggccgg cacgacggtc agaccatggc ccagggcctg accgccgtag 14940 gatgtgtgcg gcaggtcagt gggtagcttt gaatcagatg agacagtggg ggctacagca 15000 cgtgctatgc aacattaccg ataaagcaac gtccttgcac agagctggtc atgtaggtga 15060 ccggggacag tggcttcctc ttgtgactac ggagtatttc agtctttatg ctttttgatg 15120 ttttcaactt tctcaatcaa ctgtgtatta ctcttataat ggggaaatga cctacacaaa 15180 cctggaggaa aacagaagca catggctatc ccagctgttc tggaaagaaa cattttaaac 15240 cctgagaaaa gtggaagagg ttctggaaat ttcagagtta gggtaagtgg gcacttatca 15300 agcacctctc ttggctgggc gcagtggctc acgcctgtaa tcctagcact ttgggaggcc 15360 gaggcgggcg gatcacgagg tcaggagatc gagaccatcc cggctaaaac ggtgaaaccc 15420 cgtctctact aaaaatacaa aaaattagcc gggcgtagtg gcgggcgcct gtagtcccag 15480 ctacttggga ggctgaggca ggagaatggc gtgaacctgg gagtcggagc ttgcagtgag 15540 ccgagatccc gccactgcac tccagcctgg gcgacagagc gagactccgt ctcaaaaaaa 15600 aaaaaaaaaa aaaaaaaaag aaaaaagaac ctctctccag ttagcatcaa atgaacagaa 15660 aacagtaaaa ggaaagaaag tgacatccac actgaactga aagagccaca tcctccagaa 15720 gtaaccaaat ttacacccac ctgaaggagg acgcgtgccc ctaactgctc cccacacctg 15780 cagtgaggct ggagccgtgg agctggtgtg gagcgccctc cggctcccct ctgctagggc 15840 ttaaagagtg ggtgggattc caaaaagatc caaacactct ggtggactct gcttcctgga 15900 gattaggaga gggccagagc cgaggctctt caacccagca aggcctgcgt caaacagcac 15960 cgtctctgcc ttctcagaac tgaagaattt gggcaacggt cccggccctg accggggggc 16020 agccaccact gcacagtccc ttaggtgaga cgtgggtcct ggcccctgga gaaagcccac 16080 ggtcacctgc ctcatctggg agggagactg tattagggtt gtctagaggg acagaactaa 16140 caggatagat atatagagaa aggagagttt attcagtatt gacacaggat cacaaggtcc 16200 cacaataggc cgtctgcagg ctgaggagca aggagagccg gtctgagttc caaaaatgaa 16260 gaacctggag tccagtgttc aagggcagga agcatccagc acaggagaaa gatgtaggct 16320 gggaggctac accagtctct cttttcacat ttttctgcct gcttacactc tagccgcact 16380 gtcagctgat gagatggtgc ccacccagat tgggggtggg tctgcctttt cccaggccac 16440 tgactcaaat gttaatctcc tttggcaaca ccctcacaga cacacccagg atcaatactt 16500 tgtatccttc aatccaatca agttgacact cagtattaac catcaccgac actaaacctt 16560 Página 89

P201430887 ES 2 553 786 A1 09-06-2014 cacaccaaaa tgagttacca acccgagatc cccagacctg agaggagact gagccggaca 16620   gacaggcaaa cccagccctg attctaaaaa cagagcatgc ggaggcacca actggtagtc 16680 tcatgagatt ttagaggacg ttgtatccgt aaagagaaca aagtgttagg aagaggggta 16740 cgtgaaattt aaaaatataa tcatcatccc agagtgtgca gaggcgccaa ctggtagtct 16800 catgagattt tagaggacat tgcatccata aagagaacaa agtgttagga aaaggggtac 16860 gtgaaattta aaaatataat catcatcccc ccaaaaggca ctaactagac aaatgaatgc 16920 agttgaaaac tgaatttctt aactaaaaag ccagttcgag gaaccttccc tggaaataga 16980 gcaaaacccc aaatgattga tatcttgagg aggaggtaaa agacatggac gacagattag 17040 ggaaatcgaa tcagtgtccg aaagggagat ttcaggagat gagaggcaat agccaatgtc 17100 caggagaaca gatgcgtgag ttcaggaaag acgaatctgc agatagaaag actcgtgacg 17160 ggccatgcag ctgaaagaga aaataaacct ccgcagacat agctggtggg atttccaaat 17220 accacggcaa aagaaaaaat gctgcaggct tccaggcggg aaaacccaga tggcctcttg 17280 aggccgggcc tgggctacgc tttcatcaag gcctccatca gctgcgcctt ggaggaacca 17340 gggagagctc aaaaccacca ggacctatcc cagcccagat ttcagattgg tttgttctgg 17400 gaaggaccag gcattgtttg tttctggctt tctttttgac ccttaagctt ccagatgatg 17460 ctaacttgca gccagggctg agaatcacag atcttaaatt taaatagcag gatgtcaatg 17520 catacagaat tcagaattct cttttttgtg ttttttgttt gtttgtttgt ttgttgagat 17580 ggagtctctc tctgtcgccc aggctggagt gcagtggcgt gatctcagct cactgcaacc 17640 tccacctccc gggttcaagc gattctcctg cttcagcctc ccaagtagct gggactacag 17700 gggcccgcca ccatgcctgg ctaatttttg tatttttgta gataacgggg tttcaccatg 17760 ttggtcaggc tggtcttgaa cccctgacct cgtgatccgc ccaccttggc ctcccaatgc 17820 atacagaatt ctaagggaga aggatggtta gcatttgacc tacatgtcag ttagactctg 17880 gaaattaaca acaacgggaa gtccacgcat gaagacttct ggctgcagcc aaatctgctc 17940 agacaaaacc catgacagag tttatttaca tttccacaaa caagcctgaa aacagacatt 18000 ctattcgaga agctaaaaag agggaaataa actgaaagaa gcagaaaaat aaaccaataa 18060 agatcaaaag cagaagctga tgaaataaat aaaaaatgaa ttgacttgat aaataaactg 18120 cttttttttt aaatgaccaa taaaccttac acactgctgg cttatctggc aataaaaagg 18180 agatcatgca agtaacagtg ttgggaatga ggacaacttg ggggagggtt ttttttgttt 18240 tgttttttgt ttttaattgc aagaaagcta tgcattgtac tggtttcatc atgcaagaaa 18300 ttgaaaatgt caaaaatctg ttttccctaa atgcaccagt attggaagat gttatggaag 18360 gcttctagta acctttcaag gaacaaacac ttcctgtgtt atcaaagctc cagggcatgg 18420 aagattccgg aaactcccca caggctggtc ctgcaatgct tagtgaaagg ctggctgcaa 18480 acgctgacag catacaagca ggaaactgta aagcggcccc acatgtgagg agtgaaaatc 18540 ctgaacaaaa tgttagcaaa aataagtagg atttacttcc agaattcaca caggaataat 18600 tcacaattag gaaatctact aattttgtgc attatattta taaattaaag aatggaggcc 18660 Página 90

P201430887 ES 2 553 786 A1 09-06-2014 ggatgtggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcagattac 18720   ctgaggtcag gagttcgaga ccagcctggc caacgtggtg aaaccctgtt tctactaaaa 18780 gtacaaaaaa ttagccaggt gtggtggcag gcacctgtaa tcccagctac tcaggaggtt 18840 gagacaggag aattgcttga gcccaggaga cagaggttgc agtgagccga gactgtgcca 18900 ctgcactcca tcctggccaa cagagtgaga cactgtctca aaaaaaaaaa ataaataaat 18960 caaataaaac aaaatacaag gataaaaaaa aaaggcttcc tgggtgggtg ccaaatgggt 19020 atttaataaa actcatcatc catcccaaag taggatagaa ggagagttct aagtatttat 19080 cagaaactaa caagaaaatg ttacccagtg gaaagactag acttaaaatc aggaatgaga 19140 tgaggaggcc tgctagcata gcagttaccc cagactgttt tggaggctcc agcaacgcaa 19200 agaaaacaag agaaagaaat gagatatgga tctgggaatg aaatactgaa attctcaacc 19260 tctactaatg aaaaataaaa gccaatagaa acagtaagaa atcaataaag tagctggata 19320 ccagctctgt agttttcttc tacaccagta atatagttag gaattacaat ttttaaaaaa 19380 gctcattcat aatagctata acaactttta aataagtcca ggaagaaatc caacaaggaa 19440 tgatgagcct gtctgaaaaa aaacaataaa tgttatgaaa ggtcataaaa cagatttaaa 19500 taaatggagt gcccacgtta ccagctggga agacgcatga tataaaaatg ccatttccct 19560 ccaaattagc aataaaacca ttgcaattcc cgttaccctc cgtggtgaga tgttttgggt 19620 gaacttaaat ttattcaaca taattattta cttattttgg aaaagtaatg attcaaaatg 19680 caagagctct acaactaaga ggaagttttc gtctcttttc cccttccccc acccagccac 19740 cagggccctc cgcagaggca acgtagattc ttgtggattc tttttgtttt tgttttcttc 19800 gagacagcga gacgcatctt gctctgtttc ccaggctgga atgcaatggc agagtagcct 19860 cgaactccca gccttaagtg atcctcacac ctcagcttcc caagtagctg ggactacaca 19920 cacaccacca ggcctggcta attttcatat atatatatat atatatatat atatatatat 19980 attttttttt ttttttggta gaaacagggt cttactgtgt tgcccaggct ggtctccaat 20040 tcctgggctc aagtgatcct cttgcttcgg cctcccaaag tcctgggatt acaggcataa 20100 gccactgtgt tcagcccttg tggagtcttt tggagatttt ttgcatatct aagcaaagtc 20160 acaagggtgt gtgtgtatgt gtatctctct ctctctcttt aacttaaatg gctgcatatt 20220 atacccactg ctcggttcct cgcttgctgt cccttagcaa cacgtgctgc ggatattcca 20280 cctcaaaaca aaaagcacct cgggccaggt gcggaggctc acgcctgtag tgttgacact 20340 ttgggaggct gaggctggca gatcgtttga gctcaggagt tcaagaccag cctgggcaat 20400 gcggcaaaac cccatctcta caaaaaatac aaaaatgaga aattggccgg gcatggtggc 20460 atgtgcctgg agtcccagct acttgggggg ctgaggtgaa cccaggaggt tgaagctgcg 20520 gtgagctatg attgtgcgac tgcactccag cctgggtgac aaagtgacac cctgtctcag 20580 aaaacaacaa gaacaacaac actttattct caacaaattg attttaaagt tcatttagaa 20640 gactaaatgc acaaaaatat ccaagacaat tttgaaaagg aaggataatg aaagaaatat 20700 ttaagaataa taacaagtcc ttagccaggc ctggtggctc acgcctgtaa tcccagcact 20760 Página 91

P201430887 ES 2 553 786 A1 09-06-2014 ttgggaggcc gaggcaagcg gatcacaagg tcaggagatc gagaccatcc tggctaacat 20820   ggtgaaaccc catctctact aaaaaaaaaa atacaattac tcgggcgtgg tggcgggcac 20880 ctgtggtccc agctactcag gagactgagg cagaagaatg gcgtgaaccc gggacgcaga 20940 gcttgcagtg agccgagatc accactgcac tccagcctgg gcgacagagt gagactctgt 21000 ctcaaaaaaa aaaaaaagaa gaatagcaag tcctcaaaga gaacttagag gaaattactt 21060 tggaatttag ctactgcaag ctatattaat gcacaggttg cttttttttt gagacagagt 21120 ctcactttgt cacccaggct gtagtgcagt ggcatgatcc tcccacctca gcctcctgag 21180 tagttgggat tacggacgtg caccaacaca tcctgttaat ttttgtattt tgagtagaga 21240 cagggtttca ccatgttggc tagactggtc ttgaactcct ggcctcaagt gatccgccca 21300 cctcggcctc tcaaagtgct ggggttacag gcgtgagcca ccacacccag ccaaaatggc 21360 tttgcaagtt taagctgtat ccttcgagca cacctggctc caggatgata tgcgtccagc 21420 agccttttgg cctgtaattc agttttctgt ttggatccag ccactgaaag ggagtgctct 21480 gtgcagtgag caagcaagta ctgacccacg tgtagctccc tcaataaatt tgcactccag 21540 ctttagaaat ccatctcatg gccgggcgcg gtggctcatg cctgtaatcc cagcactttg 21600 ggaggccaag gtgggtggat caggaggtta ggagatggag attatcctgg ctaacatggt 21660 gaaaccccgt ctctactaaa aatacaaaaa attagccggg cgtggtggcg ggcgcctgta 21720 gtcccagcta ctcgggaggc tgaggcagga gaatggcgtg aaccctgggg gcggagcttg 21780 cagtgagtcg agatcgcgcc actgcactcc agcctgggcg acagagcgag atttcgtctc 21840 aaaaaaaaaa aaagaaatcc atctcatgca agttttgtta aaggaatcag ttcctcgggc 21900 cttggcctcc tctgagagca ctgacataaa tctgtcactt aacttgggac aggatggaag 21960 ctgctgcctc ttctagcctc gtcctctctg gcctgcactg ctgtgcagcg gtgtcagtgc 22020 aggggcatct gtggagctca gcctgccctg gatgttctcg tctcctccca ggggacttaa 22080 gactccacct aaggttgcca gcctttcagt ggtaagacat ctatgcaatc aacccgaagc 22140 cttaccacct ggcactactt cagtgtatcc ttagactacc aggaggatct ctgagacttg 22200 gtggggaatg gaacagcttg ctgcaatttg tggatgtaga ttccgtatat ttttgtctct 22260 tccaagagac tgtaaactct ttgctgacaa agtctgtgtc ttgatagttt aaaagcagtt 22320 tcccagtctt acccaaaaat ggcaggaagg gtgcccagaa cggctgttcc ctgcttcctc 22380 ctgggtctct gcatggggga cgctgggaca gcctccccac tcactctctc tctctttctc 22440 ccccgccgcg ccccgcagtg gcggctctgc agactgagat ggagaacttg gccctgcatc 22500 tcttctacat gcagaacatc gaccaggaca tgcgtgacga catccgcgtg atgacacaag 22560 tggtaaagaa ggccgagacg gagaggatcc gggcagaaat cgagaagaaa aagcaggtat 22620 tctgcaaact cgacacatgt ttaatgatca ccagaccgtg gagcttcaaa aaggggctca 22680 gctttgcctc ctgcgtgaag gcttccggcc ggaggggtgg cggccggcct gggtggcgtc 22740 aacttgtatc aagggttggt ggagaacagg ccctcagcca cgggcacctc ctgacggggc 22800 tgcttctcat cctgtttccc aggacctgta tgtggaccag ctcaccactc gagcccagca 22860 Página 92

P201430887 ES 2 553 786 A1 09-06-2014 actggaagaa gacattgccc tgtttgaggc tcagtacttg gcccaagctg aggacacccg 22920   gattttaagg aaagcagtga gtgaggtaaa agcagtcccc gcagctctca gtgttcgacc 22980 ctccagtgag tgtccacgca cagggtgctg gtgggtctac tagactgcac ctgcccgtct 23040 gctggatgag tgactgcagc cagcttacat ctgcaaacat cgggccctcc ccatggtggg 23100 gccacagtag atactgacag gtggacagcc cggattccta ttccttccct ggctagtggg 23160 tgacagaagg cctcgcaggg ttcaggtact ctagtcgctt catgaccgcc aaggccagct 23220 tgctgcgggg atgctcagca agttccttag cctgcaggga cctcttccgg ggaggactga 23280 agtctttcta acaattctca cccccgtggg cagccggcct tccgggtagc tcctacatct 23340 ctgcacctcg tggagtaggg agtggaggga acgaaggggg tgaaagctgc tccctcttgg 23400 ccccagattc aggtctgtag tggtagcacc agaaaccaaa gttactgcaa cttaaaaaaa 23460 aaaaaaaaaa aactatgagt caccatcttc attcacgggt gcgggaatga cacggaggaa 23520 acaattaact tttttttttt ttgagacaga gtctcgctct gtcgcccagg ctggagtgca 23580 gtggcacaat ctcagctcac tgcaacctcc gcctcccaga ttcaagcaat tctcctgcct 23640 cagcctccag agtggctggg actacaggcg cccacctcca tgcccagcta atttttgtat 23700 ttttagtaaa aacagggttt caccatgttg gccaggttgg tctcaaactc ctgacctcag 23760 gtgatccacc cacctcggcc tcccaaagtc ctgggattac agtcatgagc caccgtgccc 23820 agccaatgaa aaagaaggaa gaggacttga aggaacggat gagcacgctg ggctcccagg 23880 gtaaagggag ggcccggggc tgggcgttac tcagcactgg tctctccagc tacaaatgca 23940 attaaagtag agcacgtccc aatcagaatc tcaggaacaa acaatccctt agttaacaaa 24000 acaattctgg agttttatct gaaaaataaa ttaggaaggc tagccaagaa tggttttgga 24060 agagaagatt caaacggggc aagcagccat cccagtctgc tcaggactga ggggtcccca 24120 agacaaggga ctttccatgc taagcccagg gggtcctgga cacagcagga tggcagatca 24180 ccctagcatc gccgcaccaa atattaaagt atacagtaaa gctctggcca ggcaaggtgg 24240 tgcacacctg taatcccagc acttggggag gctgaggcaa gaggatggct tgagcccaga 24300 agttcaagac cagactgggc aacatggtga gaccctgtct ccacaaaaaa ataataatta 24360 aaaaaaaata aaacattagc ccaccatggt ggtgtgcacc tgtggtccca gctactcagg 24420 aggctgaggc aggaggatca cttaagcccg ggaggtcaaa aaaaaaaaaa gaacaacaac 24480 actttattct caacgaattg attttaaagt tcacttagaa gactaaatgc tcaagaatac 24540 ccaagaaaat tttgaaaagg aaggatcatg aaagatcctt gaactatgaa agatccaatg 24600 aaatatgatc ataccactgc actccagcct gggctacgga gcaagaccct gtctaaaata 24660 aaacaaaacc gtaaagttct agaggctaaa ataatgtgtc acaagataga caggcaagac 24720 attgaagcct atgagagagc cccaaagcaa gccagagttt atataaaaac ctagtagatt 24780 ataaattacc agagagctaa tgaattatgc atccaatgat gtcgggacat ttggttaatc 24840 atttgggaaa aaattaaatc ttttcctcat accagacact aaaataaatt ccagatggaa 24900 tcaagtattt aaatggggga aaatgtgcca gacgaaaaca aatgaaaata tttatataat 24960 Página 93

P201430887 ES 2 553 786 A1 09-06-2014 cctgggctgg ggaggccttt caaagtataa caccaaaagc aggaacctta aaggaaaaga 25020   ctaggagggg ccgggtaagg tggctcacgc ctgtaatccc agcactttgg gaggccgagg 25080 ccgctggatc acctgaggtc aggagttcga gaccagcctg gcccgcatgg caaaacccca 25140 tctctactga aaatacaaaa attagctggg cgtggtggta cacgcctgta atgccagcta 25200 cttgggaggc tgaggcagga gaatcgcttg aacccaggag gcagaagttg cagtgagccg 25260 agatcatgcc attgcatttc agcctgggcg acagagccag aatccatctc aaaaaacaaa 25320 acaaaacaaa agactaggag gacaatcaca ccctcaataa aacctttgta gattaaggac 25380 gccacaaacc agatgaaggc ggggagacag gcaggagaag acaactcgca gccattagta 25440 aatccggggt tgtgaagaga ggctgaaagc caaggagact cgccctgtgt gcttccacac 25500 cctggaggca ggtgggctac ttggtagatg cttccttttg cacctcccgc cctcccctcg 25560 atgcaacttc cccagggaag ggggccgccc gcacttcctt catttctcat ttccagtacc 25620 cagaacagtg cgggggcaac agcagggccc ctgttcatcg agcgaagtca caagtaacca 25680 aaggacaggg agtcccctac agagttggca aagataagga gagatgagcc ctccctgctg 25740 tcggccatga aaatacagat tggcctttat ctttatcaag atcttcatcc agggcgatat 25800 gatcatatgc agccactccc tccctaaccc taaccctaac cccgcaccct gttagtgctt 25860 agactccatt ccaaggaacc tagcaaagac ctatgcagat aacatttttg tatgttaaaa 25920 atgataaagc caggcttggt ggggtgcacc tgtagtccca gctactcagg aggctgaagc 25980 aggaggagca cttgtgccca ggaagtcagg gctgcagtga gctatgattg caccactgca 26040 ctccagcctg ggtgacagag tgaaaccccc gtctctaaag aaataaatac agtgaataga 26100 gactcatggg ggagatgacg ctcatcaccg tgttgtgtca tcagaaagaa agaccccaag 26160 aagaggacat tagtgaaacc cattttcata cacctgtgca tcagaataca ctacaccaaa 26220 aagagctcta ctgacatgga aacctgtctc gatattaatt tcttatttta atttttttta 26280 aattatactt taagttttag ggtacacgtg cacgatgtgc aggtttgtta catatgtata 26340 catgtgccat gctggtgtgc tgcacccatt aactcgtcat ttagcattag gtatatctcc 26400 taatgctatc tctcccccct ccccccaccc cacaacaggc cccgttgtgt gacgttcccc 26460 ttcctgtgtc catgtgttct cattgttcaa ttcccaccta tgagtgagaa catgcggtgt 26520 ttgggttttt gtccttgcaa tagtttgctg agaatgatgg tagagactaa gtctcactct 26580 gtcccccagg ctggagtgca ctggggccct catggctcac tgtagcctca aacttctggg 26640 tccaagcaat cctcccacct cagcctctca agtaggtagg actataagca catgccacca 26700 caccgtgcta atttttttat tatgattatt ctttttgtag agacggtgtt tctttttgtt 26760 gcccagactg gttgggaact cctggcctca agtaatcccc ccgcctcagc ctcccaaagt 26820 gctgggatta cgggcatgag ccaccgcacc tggcacaata cattaatttt taatatggcg 26880 gggcatggtg gctcacacct gtaatcccag cactttgtga gaccgaggtc ggcagatcac 26940 ctgagggtca ggagttcgag accagcctgg ccaacatggt gaaaccccgt ctctactaaa 27000 aattcaaaaa ttagccaggc gtggtggcga gtgcctataa tcgcagctgt tcgggagact 27060 Página 94

P201430887 ES 2 553 786 A1 09-06-2014 gagacaggag aattgcttga actcaggagg cggaaattgc agtgagccaa gatcgtgcca 27120   ttttgctcca gcctgggtga cgagagtaaa agtgtctcaa aaaaaaaaat taataggaga 27180 ttatgaaaca atatatagaa tttgatttcg cacacacaca caatcacagg tgtaagaagt 27240 tagaaatggt tatctctaag tgttagggtt attgaatttt cattttcttt ttgcttattt 27300 gcacattcta tttgcatagg ctgaacactt gcctttgtga aaaactgggg tctaaatgca 27360 caggtgactg agcccggcag ccatctttcc atccttatgc cttgacctgc acctcagtca 27420 accaggctgt ggccggcagc ctcaggggca ccatggggag gcctcgcaca ggctcagttt 27480 aaggtgcatc ctggctgaat ttgggtcccc acctgctgcc tgggccagct cccactgccc 27540 aatggcacag agcagcctcc ttagtgaata acttaccccc atacaaaact gtgacccagc 27600 agtcccacga ctgggcattt atccaaagga aagggaatcc gtgcatccaa tagacacctg 27660 cacccccatg gccaggctgg tctcggaccc ctgacctcag gtgatccgtc cgccttgacc 27720 tcccaaagtg ctggggttac aggcatgagc cgccgcacct ggcccagtca acaataattt 27780 attgtacatt ttcagatagc tagaagagag ggttttgaat gttcccaact caaagaaata 27840 acaattgctg gaggtgactg atacgctaat taccttgatt caagcagtac acattgtaca 27900 tgtgtcgaaa tatcactctg taccccagag atatacagct gtaacatgtc agctaaaata 27960 aaaggaaata ctacagacaa aagggaagtc agtcccggga tgtacacagt gtcccttcct 28020 aggctgccca ataatcctaa gtaagcgtct gtgagaggaa aaaaaagtcc ccctcatcgt 28080 ggtatactta attcacacca ttttaggtta cgtcgtaatg aatagatggt tcagaaaccc 28140 tcacagccaa gcatggtgtc tccagggcga tggcctctct catgcccggc gctgccctcg 28200 gctcccccgt gatgttctag cgcactgtgg ttcagtcact gtctaccaag cttgcctggg 28260 tgtcacggcg tgcaggcact tctgggactt ggcgttctac aggacgcccc agttggctga 28320 ctcgggccgc cagcttgctc aagtcacagt gcttgcattg gggatgactc atcaagaatc 28380 ccaaacacca ctcaaaacaa gaccgcgatc caggccgtgc tgggcatgca ggcatcaact 28440 cacttgaccc ggcagccccg gggtcgctcc tgtacccatg gaggtgccgc tcctgtaccc 28500 atgtcacagc tggggacact gaggcacagc gggtgagatt cagcccaggc agccgtacca 28560 gccttaacct ctgtgcccca agcataaagg aactcccctt tcccttggag taaattcctg 28620 aaccaccccc ctagttttca agcccctccc ctgcatgggc caagccctta ctgcaggtgg 28680 cccctcactg ccccccacga tgcccctaga cttccagcct ccgctcagcc tgcctgacct 28740 gcccacccct ggctgtccag ttgtgcctcc tcattcccag tctaggcagc cctgcttccc 28800 ccagctggac gagagcatcc agccctggcc attcttgaga caaacacctc cttccatcat 28860 ggcctcccta caggaagcgg tgctgggccc gtcctgtggg acctcagtcc gaatcaatga 28920 caccaccaac cctgcagagg tgtttcacgg atgctggcca ggatcccctc ctcctctccc 28980 tcctcctctc cctcttcctc tccgtcttcc ccctccccct cctccctctc cccctcctcc 29040 ctctttcatc tcctccccct ccctctcccc ctcctccctc tttcatctcc tccccctccc 29100 tctccccctt ctccctcctt catcttcccc ctcctccctc tcctcccctc tccctccttc 29160 Página 95

P201430887 ES 2 553 786 A1 09-06-2014 atcttccccc tcctccctcc cccttcctcc ctctcctccc ttccctcctc ctcctcattc 29220   ccaagcactg agcaccgcag gccctgagca aaggctcaaa gcgggtacgg gttatcttga 29280 aagctacatt caggctcgtg tttacccctc tgcagatgca tgatcaagga aagtaccggt 29340 gatagaagga aaagaggaag atttgggaat gtgaggctct ggtgttcttg ggctttgctc 29400 gcaaatgaaa tgagacagcc attcctgccc cctcccctgt tggctgcagg cctgcaccga 29460 gatcgacgcc atcagcgtgg agaagaggcg catcatgcag caatgggcca gcagcctggt 29520 gggcatgaag caccgcgacg aggcgcacag ggcggtgctg gaggcgctca ggtactgcag 29580 ggccacaggc agcgaggatg tgcgggaacc ccaggggtcc gtggcaggcc cgccccacac 29640 cccctctctc tgggtccacc ggatctctgg gacagagggt gcaccttgat ccccgggtcc 29700 gggcttccgt ccggaaagct ccctcattgt ttggtaagat ttcagcgatt cttaaatcct 29760 ttccaacact gcggcgctgg gaggggagag gcttttctgc tcagatttcc tggcaggatt 29820 aagtagaaac agagcagggt aaagagaaag ctatctttgg gaggtaaagg tgtccctttg 29880 atttgcagta tcaccacctg agtgcggaaa ccccatccct tctcgattgt tctgcctgag 29940 ggctgcattc caaccgaaat cctattttaa tctccaaagg aaggggagga agaggcctcc 30000 tctgggcatc ccctcacttc tggggatgga tgcgtggctc agggcagggc gttggagaca 30060 caggtgctgc cttcattcct aaaaccaccc agggtgacca ggtctcggga cgcggaaaga 30120 aaaagccggg cactgtggtg gcacgtgtct cacccgctga gctttaactt cccctccacc 30180 tttcgtagtc tccacccctt gtgcccagca cagagcctgg catacagcaa gcgctcaaga 30240 aaggctggac caaggaatga gggtctggct ggccccacag cacccgcagc caggcagcca 30300 gcagcagtca cacaaccagg agatgctttt ccttttgggt gctgtgatta aagaaacaaa 30360 atgaaaccat tttgttttta aaagttttta gaccaaaaca ttttcaaatg aataatattg 30420 gattaaccat actcatttct ggccaggcgc agtggctcgc acctgtaatc ccaacatttt 30480 gggaggctga gacgggtggg tcacgaggcc aggagttcaa gaccagcctg gccaagatgg 30540 tgaaaccccg tctctactaa aaatacaaaa attagccagg catggtgtgg gcgcctgtaa 30600 tccccgctac tcgggagggt gagacagaga actgcttgaa ttgcggaggt tgtagtgagc 30660 cgagatcacg ccactgcact ctagcctggg agacagagca agactctgtc tcaaaaaaaa 30720 taaaaataat aataatactc atttccttca ctcccttgag tcaacaacat aaagccaaag 30780 ggaacactgt ggtttgatac aggcgatgtt tggctgaagc ttcgtttccc ctgtaaagat 30840 gcaggtcgag gaaccagagc cagctgtggc cgggcaaggg ctcctctccc tgtgtcacca 30900 gggttgcctg aacaccagga cgagaggact tggccatctg cccacttggg tgtctttttc 30960 ctcctgcccc aatgctagga cttgatacct gactgtttaa ttacacggct cagctgccac 31020 gggccttaag aaaagtcaag gccaggttct ctctgagggt ccagcacctg gcctggctct 31080 ccgaggctca tggcctgtga accctgcagc gtccccaagg gaagacgtca cctccgagat 31140 ggtcctgttg tccagctctc ccctgcatcc cagactaacc agtgtcctct ctgcaaaccg 31200 tcctcattgc cctcagagac atggcttcct tttggttgca aacattgtaa aaatcgtatt 31260 Página 96

P201430887 ES 2 553 786 A1 09-06-2014 cgatcaggtc tcctcctcct cggcccgcag tcactagaac cccctcccaa gacaagcaaa 31320   ggcacctggt tttctgggat cccctgccta acttgtgtgc aattgcaaga aagcatatgc 31380 gttcacccgg agtcttcctt ccctctcttg ctccgtggga gcacaccaca ctcactgttc 31440 tgcacctctt tgctttttcc atttaacagc gtgtccctag agcgcttccc aagtcaaaat 31500 ataaacaccg ctcgttcccg cctttctacc acatggcatt ccgctgggat acttctacgg 31560 ggaagcttcc tgcccggggc atcgagggcg ttcgcgtccg tctgttatgg cggtgctgct 31620 gtagataacc ggatccgcga atgctaacgc tcaccaggat gctatatagc cttttttata 31680 ttgcctatca agcccggaat gtctgggtct agcgggtatt gctaagtagg attgtgacag 31740 tcacgccccc ggcagcggtg tttcaaagtc ccctgacagc tcagcatgtt gtcacacttc 31800 aggactgtgc caatccgatt gatgaagaaa atagataatc ttgttttata aaacgtgcat 31860 gcgcagaatg ttgagtgaat attttagtgg actatgtaca cgcacaaaca cttcacaacg 31920 agtgagagag cctctgactt cacctgcagc ttgccacacc aaggccccgg ggaggagtga 31980 ggcccaactt ttatttatta tatttttgtg gttcttgcaa tggagtctcg ctctgtcccc 32040 caggctggag tgcagtggca ccatctctgc tcactgcgac ctccgcctcc tgggttcaag 32100 cgattctcct gcctcagcct cccaagtagc tgggattaca ggcgtgcacc accacgcctg 32160 gctaattttt gtatttttag tagagacggg gtttcaccat gtgggccagg ctgatcttga 32220 acccctacct caggtgatcc acccgtcttg gcctcccaaa gtgctgggat tacaggcggg 32280 agccactgcg cccggccagt cttttaaaag tgcaggccgt gtagaacatt gtgagaagta 32340 taaactgtaa ttacagagat ttgctgtttg cacccagata gatttgaaga agcaacttgg 32400 agacaggttt aatagatcag ggccattatt acagaaataa attattgcat agcttaggac 32460 ttccaagcta ggagtgcagt gactgaacta tacctcaaat attgaccttg agatgttcag 32520 atttgtagag catcttagaa aatggtgaca ttcctggctg atggtcagga tggtgcatac 32580 caggccggta ccctggtggc tgtctgggca tttctggagc cttcaccctg cgagatcccc 32640 atggggcagg accccctggc ccagaagctt ggttttgcca tcacaccgag aaggcacact 32700 tgtcctggag ttagtttaca tgaatcgagc tcaccagagc ctgacgtgta actgagtata 32760 atagcccatt tatgtgcatg atgaaatata aacaccaaag aaccgaatgc tccacgctcg 32820 gactagcaga ttcttatctg tgggggagga cacaggagcg gatgacacag acccctgctc 32880 agggaccggc tagagggcgg aatgcctggg ccccggccct gtctgcttcc tgcttcttcc 32940 ccgaagttca tggcctgtcc gtccacatgg gcgggaggtg tcccgcgagc agccctcacc 33000 ctgaccttgg ctgctttctc cattccattc cccacccctc ctccctcctg acacccatgg 33060 cattttttca gataagttaa tacctttgat taggttccag ccaaacctca ccctttctct 33120 ttccccatgc ctttgtgtct ctcttcgtct gatgtcgagt ctacaaccta atgctttgaa 33180 gacagactga cttccccgtc cttggtcagg gggttgctgc tgcgtggggg gggcggtaac 33240 cataatcttg cccccgtgtc tcatacacaa gctgcaagct tagctcagaa gctgtgcctg 33300 tcttggctgc tttttcttgc tgtcttccct atttttgcag gagttttgca cacggtcata 33360 Página 97

P201430887 ES 2 553 786 A1 09-06-2014 aaagttcagg agaaacatga aacgtgttat tctgtttcct gtttaagtcg acctgaggaa 33420   gctgaagggg tcaggcgcgg tggctcacgc ctgtaatccc agctctttgg gaggccgagg 33480 cgggcagatc acgagctcag gagctggaga ttgaaaccat cttggctaac atggtgaaac 33540 cccgtctcta ctaaaaatac aaaaaaacag ccagacctgg tggcgggcac ctgtggtccc 33600 agctactcag gaggctgagg caggagaatc gcctgaaccc gggaggtgga ggtggcggtg 33660 aagcaagatg gtgccactgc actccagcct gggtgacaga gcgagacttc gtctcaaaaa 33720 aataagaaag aaaaagaaaa aaaagagaga gagagagaca gagagagaga gagaaaaaaa 33780 gaaagaaaga aaagaaaaga aaactgaggg cttgccctaa tctcctagac ttccttttcc 33840 ctcagtcctg atgatggcag agacgactcc tcaaaggctc ttccccttgg catggagtgc 33900 tggagcctgc cctagggagg gaggacagga tggagcaaga cactgaacgc agaattagag 33960 ctaggcaacg agcgggtgat ttcactgttt cctgggtaac aagccccagg ctcagctcgg 34020 tctggtgtag cccctcaaag gggacactgt ccttgccccc agttgatgga ggaggaagga 34080 gcggaaggca gtgtgggatg ggttgggtgt gggcattgcc acagtgtccc cagcaggcct 34140 ccttctagcc tggggatctg gcaggtgggt cccagtcacc accaatgccc catataccca 34200 aggacactgg tgacccagca gacctgaggc cacagaccaa agacagagta acaaccccat 34260 taaaaatgtg cccccatggg cgggcatagt ggctcctgcc tgtaatcaca gtgctttggg 34320 agactgaggc aagaggatcc cttaagccca ggagttcaag accagcccgg gcaacatagt 34380 aaagtaagac cttgtctcta aaataaaata taaaaaatag ccaggtgtgg tggtgtgtgc 34440 ctgtggtctc atctacttgg gaggcagaag caggatgatc acttgagtcc aggaatttga 34500 ggctgcagtg aactgtgatt gcacgaatgc actccagcct gggcaacaga gcaagaccct 34560 gtctctcaaa aaatttttaa ttagcggggc atggtggtgt gcacctgtag acctgtagtc 34620 ccacctactc gggaggctgg gtgggaggat tgcttgagcc caggaggtcg aggctgcagt 34680 gagccgagat ggtgccactg cactccagcc tgggcaacag agccagagcc tgtctcaaaa 34740 aaataaaaaa gtgtccccag acacaggggc atgggtgagg cctgtcagga ctgctgtggt 34800 agctcatggt gtcctgtccc ttcttcccac cagggaatga ccgtggctgt gggcacaccc 34860 cctgtccatc tgggcctgcc tgtgggagct ggacactgcc ctccccagca gccagaagtc 34920 ctgaaggaac cgtgtgtgac cctcaagacc agaccgggcc tgccacacca acccttcaaa 34980 gaccgcagcg gtccaggcaa tccaacgtgg gtcccaaagc taggtgaata accacgagga 35040 gcccacggtc agccccttcc catcacatac gcagggaaat gggtcacttt cactttcaga 35100 aaacaaagcc tggaccgcac ttaacttgga ggcagataac ctaatcagaa ttcacacacg 35160 cctgggactt ggagccaaaa gcacccgtgc tcttacctgc ctttgtccta tttcctggcg 35220 ggaaatacag agggcagaca ggtcttggcc cgcagccaca gcccctttac cccaagatgt 35280 gactcggtca gccacacggc ctcacagcct cctcccaggc cctcagctgt ggccacggca 35340 gccaggcagg ccgacccaag gacaaaagcc acgggcagtg tcctgggaga gaacccggcc 35400 ttgaccacag gctgctggac acctcctgtg tccccccctt aatcctcaga ggcacggtgc 35460 Página 98

P201430887 ES 2 553 786 A1 09-06-2014 ccaatgcctg ggccatattc cagattccat ccgttctttt tgtttcattt acagacagtc 35520   cccgacgtca cgatttttgg actttaccat ggtattaaag caacaggcag gcaacagaaa 35580 ctgggctttg agtcccacac aacctccctg gttttcagca cggtattcaa taaattacat 35640 ggatgcccca cactttatta tcaaacaggc ttcgtgtgag atgattttgc ccacctgtag 35700 gctcatggga gtgtcctgag cacgtttgag ggaggctggg ctgagccggg gtgcctggca 35760 ggaaatctgc aggaagtgca ttttgggttt ttcagctttt tttttttttt ttttttttga 35820 gatgaagttt cactcttgtc gcccaggctg gagtgcaatg gtgcgatctc agctcactgc 35880 aacctccacc tcctgggttc aagtgattct cctgcctcag cctctcaggt agctgggatt 35940 acagacatgc accaccacca tgcccggctg attttgtatt tttaaaagag acggggtttc 36000 accatgttgg ccaggctggt cttgaactcc tggcctcagg tgatctgccc ccacttggcc 36060 tctgaaagtg ctgggaatta caggcgtgag ccacggcacc agcctgcatt ttggacttag 36120 gatattttca acttacgatg ggtttgccgg gctgcatccc caccgtaagc tgaggagaac 36180 ctgtactttc tattggtgcc tgctgatcta cggagttttt aaagtacgat ttaaaaaaat 36240 aataatcctt atcaaggata agtgattgcg ttacaggaca tttgaaaaac agagaaaagg 36300 atttaaaaat accatcgact ttctcttttt gtgacaagaa gactcattag catgtcagca 36360 cactctcagg cacacatttc cccgagtgtt aggagttctg ttgcacagtt tgtaactgta 36420 tctttttaaa ttgggcatct tatttttatt gtcaaattta gacatttata aggctgctcc 36480 ttcctaaaaa aagaaaatga gtaacttatt tacttgaagt caggatgact ggggataatt 36540 tatgtacaaa attgcatacc tccagccctg gcaaccgctg tgccgccttc tgtgcctata 36600 gctctgccat ttctagaatg tcatataaat ggaatcgcgc agtctgtagc ttttcttgtc 36660 tggcttcttc cacttggcat catgcttttg agacccaccc atgttgcaag atcagtagtc 36720 tgttcctttt tattgttgaa tagtattccc ttgcacggat acatcagatg tatttgtcca 36780 tccaccaact gatggacatt tggcttttac ctttggaata ccgtgaagaa agctgctgtg 36840 gctgtcctga aaagatcttt gcatggagac gtgtttccgt ttctcccggg taaatacagg 36900 cgcatctcgt ttcagtgtgc ctcgctttct cctactgcgt ggaatcgctt ttgtttgttt 36960 gtttgtttgt ttgtttgttt gtttttgaga tgagtttcac tctgtcaccc aggctggagt 37020 gcagtggggc gatcttggct cactgcaacc tccacctccc gggttcaagc aattctcctg 37080 cttcagcctc cagagtagct gggattacag gcacatgcca ccatgccctg ctaatttttt 37140 gtatttttta gtagagacgg ggtttcactg tgttagccag gatgatctcg atctcctgac 37200 ctcatgatcc acccgcctca gcctcccaaa gtgctgggat tacaggaatc gcatttttta 37260 caaattgaag gttgacggca gctccgtgtg gagcaagtcc accggcacca tctctccagc 37320 ggtgcgtgct cacttcctgc ctctgcacca catgttggtc gttctcataa tatttcaaac 37380 tttttcattg tcatcgtccg ttatggtgat ctgtgatgag tgacctttga tgttaactat 37440 tgtaattggt ttttggcaaa gccacgaact gcccttgttt aagacagcaa actgaatcaa 37500 gacatgtcgt gtgtgtactg actgctcgcc ggctggcgtt cttccatttc tgtccctctc 37560 Página 99

P201430887 ES 2 553 786 A1 09-06-2014 cttgggcctc cctattctcc aagactcaac agtattgaaa ttaggcctac aatggccact 37620   aagtgctcaa gtgaaaggaa gagtctcatg cctctcactt tatttttatt ttatttattt 37680 atttttgaga cactctgtcc cccaggctgg agggcagtgg cacgatcttg gctcattgca 37740 acctctacct cccgggttca agcgattctc ctgccccagc ctcccgagtg gctgagattg 37800 caggtgcctg ccaccgtgcc cggctaattt ttgtatgtta gtagagacag ggtttcacca 37860 tgttggtctc gaactcctga cgtcaaatga tctgcctgcc tcggcctccc aaagtgccgg 37920 gattacaagt gtgagccaac gctcctggcc gcctctcact ttaaatcaaa agttagaaat 37980 gattaagctt catgaggaag gcatgtcaaa agctgagata agccaaaagc taggcctctt 38040 gcaccaaagg gatagccaag ttgtgaacac aaaggaaaag tttttgaaga aaatttaaag 38100 tgctgctcta atgaacacac aaaagaaagg gaagcagcct aattgcgcgt ctggagaaag 38160 ttcaggtggt atggacagaa gatcaaacct tccggccggg cgcggtggct cacgcctgta 38220 atcccagcac tttggaaggc ccaggcaggc ggatcacgag gtcaggagat caagaccatc 38280 ctggctaaca cggtgaaacc ccgtctctac taaaaataca aaaagttatc caggcatggc 38340 ggcaggtgct gaggcaggag aatcacttga acccaggagg cggaggttgc agtgagccga 38400 gatcgcgcca ctgcactcca gcctgggcaa cagagcgaga ctctgtctca aaaaagagaa 38460 tgcacctggt gggcatgcta gctcaagtaa tctcagcact ttgggagggc aaggtgagag 38520 aattgcttga ggccaggagt tctagaccag cctgggcaac atagcaagag cctgtctcta 38580 aaaccgaaaa aaggaaagaa agaaaatgta cctggtcacc caagagtttt gatggagctg 38640 gagctgtgca agatgaatgt tgtttccaca cctgtaacac agcatttatt ctgcaaccca 38700 tgggttgagg agtaatttca actttcaagt cttactattg cagtaataca gtctgtaaag 38760 ctatagctgt catagatagt gattactctg atggatctga gcaaagtaag ttgaaaacct 38820 tctggaacag actcaccatt ctagataacg ttaaggatat tcgtgattca tgagaggagg 38880 tcaaaatatt actcttggtt tttttgaggt ggagtcttgc tctgttgccc gggctggagt 38940 gctatggtac gatcttggct cactgcagcc tctgcctccc ggattccagt aattctcttg 39000 cctcagactt ctgagtagct aggattacag gtccttacca ccacacctgg ctaatttttt 39060 atatttttag tagagatggg gtttcaaccg tgttggccag gctggtcttg aactcctaac 39120 ctcaagtgat atgctcacct cagcctccca aagtgctggg attacaggca tgagccacct 39180 cagcctccca aagtgctggg attacaggca tgagccaccg tgcctggccc aaaatattac 39240 tttttttttt tttttttttg aggtggagct tctcttttgt cgcccaggct ggagtgcagt 39300 ggcacgatct cagctcactg aaaactccac ctcccaggtt caagcaattc tcctgcctta 39360 gtctcccaag tggctaagat tagaggcacc tgccactacg cccaactaat tttatttttt 39420 taaggttgga attgctttta ttggggacag atgtgcaagt ccccgctcat ggtcaggtta 39480 gtgttctgcc cttgcagagg tgccagcagc ctgacacctc catctgccgc ccgccccggg 39540 ttagtggaac atgcaaagct cagagggtgg aggcaggggt ggtcgctgct gaagccagac 39600 gtccagctaa tttttgtatt tttagtagag acgggttttc accatgttag ctaggctggt 39660 Página 100

P201430887 ES 2 553 786 A1 09-06-2014 ctcgaactcc tgacctcagg tgatctgcct gcctcggcct cccaaagtgc tgagattaca 39720   ggcctgagcc actgcgcccg gccccaaaat atcaccttta atggcaaaac tgcaattact 39780 tttgcaccaa cctaatatca acattaacag aagttgattg taacgcctgt ggatggcttt 39840 gagggctcag gacttcagcg cagaaagtca ctcccgatgt ggtggaaaca agaactagaa 39900 tgagaagtgg agctgagatg ggatggaatt gctgtgttca tatgatcaaa ctttaatgga 39960 tgaggagttg cttcttacgg atgagcgttt tcttgaggtg gaatctgctc ctgtgaagat 40020 gccatgcgca ttgttgaaat taacaaagaa tttagaatat tccataaact tggttgatga 40080 ggcagcagca gggtttgaga ggactgactc caattttgca agaaggtctt gcgtgggtaa 40140 aatcctatca aacagcatca catactacag agaaatcttt cataaaagaa gagtcgatcc 40200 atgtggcaat ggatgtggca ggaagagtca atccattgtc ttattttaag attgccgtcc 40260 aggtggggtg actcacacct gtaatcccaa cactttggga ggccaaggca ggcagatgac 40320 ctgagctcag gagtttgaga ccagcctggg caacatggtg agacctcatt tctacaaaaa 40380 atacaaaaat tagccaggtg tggtggtgtg cacttgtagt cccaggtact cgagaggctg 40440 agggaggtgg tggcttgagc ctaggaggct gaatttgcaa taagccaaga tcacaccact 40500 gcactccggc ctgggtgaca gagccagagt cagagcctgt ctcaaaaaaa aaaaaaaaaa 40560 attgccacag ccaccccagc cttcagcaac caccaccctc atcagtcagc agccagcaac 40620 atcaatgcaa gaccctctac cagcatactt tatcaagtat gacttgataa acacttaggt 40680 gattgttagc attttttagc aataaagttt gttttttttt tcttttttaa aatagagtct 40740 cattccatta cccaggctgg agtgcagtgg tgtgatctca gctcattgca acctctgcct 40800 cttgggttca agggattctc ctatctcagc ctcctcagta gctgggatta caggtgccca 40860 ccacgacacc tggtattttt agtagaaata gggtttcacc atgttggcca ggctggtctc 40920 gaatttctga cctcaggtaa tctgcctgcc tcagcctctc taagtgctgg gattacaggt 40980 gtggaccacc acgcccagcc taaagtaagt acattcttta gacatgatgc tattgcacgc 41040 ttgatagact acagtaaagt atgcaccttc tgtatgcact ggggaaccaa aaaagattgt 41100 gtgacttgct ttactgtgat acttgcttaa ttgcggtggc ctgcaactga acctgcagta 41160 tctccaaggt tccggctcaa catacatttt actttataac aaatgcttgc cggccgtggt 41220 ggctcacacc tgtaatccca gcactttggg aggctgaggc ggatcacttg agctcaagag 41280 tttgagacca gcctgggcag catggcaaaa ccccatctct acccaaaaat accaaaaatt 41340 agctgggtat ggtggtgcat gcctgtaatc ccagctactt gggtggctga ggcaggagaa 41400 tcccttgagc ctggtaggtg gaggttgcag tgagccgaga ttgcgccatt gcactccagc 41460 ctgggtgaca gagcgagact ccgtctcaaa aataaacaat aaaacagctg ctgcggtgtt 41520 ttcccaagtg actggttcca atttgcattt tctccagcaa tttatgagag tcccagttgt 41580 tccacatcct cgccaacatt tggtattatc agtcatctaa ttttagccat caaatatagc 41640 cattagcaaa tgtgtggtgc atcgccttgc ggtctgagcc tgcgtgtccc taatgactag 41700 cgatggtgag catctcttcc ccggcttatt cgctattcct gtgccttctc tggtgaagca 41760 Página 101

P201430887 ES 2 553 786 A1 09-06-2014 acttctgctc atttttccgc tgagtggctt atcattgagt tgtaagagtt cttcatatct 41820   tctggagaca tcttttatca gacgtgtgct ttgaaaatat ttttgtccca gtctgtggct 41880 ttgtcttttt tacctcttta cagtgtcttt tgaagagcaa aagttttaaa tttttgtgaa 41940 gtccaactta ttaaatattt tctttcctga ttcatgcttt ttatgtcttc tctaagaaat 42000 ctctaagggt caggccgggc acagtgtggc tcatgcctct aatcccagca ctttgggagg 42060 ccaaggtggg cggatcacga ggtcaggaga ttgagaccat cctggctaac acggtgaaac 42120 cccatctcta ctaaaaatac aaaaaattag ccgggcgtgg tggcgggcgc ctgtagtccc 42180 agctacttgg gagggtgagg caggagaatg gcatgaacct gggaggcgga gcttgcaggg 42240 agccaagatc acgccactgc actccagcct gggcaacaga gcgagactct gtctcaaaaa 42300 aaaaaaaaaa aaaaggaaag aaaaagaaat gtctaagggt cacgaagatt ttctcccaag 42360 ttttccacta aagttttcca ggtctcgctt ttaggcatct ggtccatttc aagttcacgt 42420 ttgttgtggt atgagcgggg tccaggctca ggttttgtgt gtctctctct agttgtccca 42480 gcaccacttg ttgaaaagac tgtcctttcc gtattgaaat cctgtgacac ctttgtcaaa 42540 gatcaatgta ttgtgtgtgt gtgtctgttt ccagactctc tattctgttc cgttgatctt 42600 tttgtcattc tttcaccaat accacattgt ctttctaact agagctttat ggaaaatctt 42660 gaaatcagat agtctgagtc tttgatgttg ttttacaaaa ttattttggt tactctaggt 42720 cctttaggtt tccatttaaa ttttaaaact tgcttgtcaa tttctgggga aaaaatgcct 42780 tctgggatgt aactgaaatt acattgaatc catagatcag tttgaagaga attgaggcct 42840 taataatatt aaatcttctg cttcatggac atggcaaatc tctccagtat cagtatcttt 42900 tttttttttt ttttttgagt cagagtcttg ctctatcacc tgggctggag tgcagcggaa 42960 caatctcagc ttactgcaac atccgcctcc tgggttcaag tgattctcat gcctcagtgt 43020 accaagtagc tgtgaacaca gccacacacc accacgcccg gctaattttt tttgtatttt 43080 tagtagagat ggggttttgt catgtgggcc aggcttcctt tctctattga tagtgtctta 43140 tcctttgaat aagtttttat tcaaatagtc agaaagtact ttcttcttgg actagaataa 43200 taccttccat atttttctca catctctccc cagtctttca attctctttc ccaagcaacc 43260 tgttactgtt tcataaaggt ctttccagat agatttcgtt catacatatg cattattctc 43320 gggtgtttat ctctccactt aaaaatcacc cgcggccgct tagtgtgtcc cgctctgcag 43380 cttggtgttt cttgtgctgt gtcttagagt tattccatgt cagaacacat agaaatcacc 43440 gttgttcttt gcagttctct tcacactgtg ttctaaatga tgcctgtgcc ataatttaat 43500 catcctcatc gatccataat gaggcccttt cctgtttttt ggctttttct gatctcatca 43560 gtggatcaat aaatatccac acacattaaa aatagatact ggatcaccag gcacggtggc 43620 tcatgcctgt aatcccatca ctttgggaag ctgaggcagg tggatcactt gaggtcagga 43680 gttcgagacc agcctggcca acagggcgaa accctgtctc tactaaaaat acaaaaaaaa 43740 aaaaaaatag gcaggcatgg tggcacacgc ctgtggtccc agctactcag gcagctgagg 43800 catgagaatc gcttgaaccc aggaggttgc agtcagccga gatcgcgcca ctgtactcca 43860 Página 102

P201430887 ES 2 553 786 A1 09-06-2014 gcctgagtgg cagagcgaga ctctgtctca aaaaaaaaaa tactggatgg ccaggcgcag 43920   tggcccacac ctgtaattcc aacactttgg gaggccgagg caggtggatc acttgaggtc 43980 aggagttcaa gaccagcctg gccaacatgg tgaaacccca tctctacaaa aatacaaaaa 44040 ttagctgggc atggtggcac acacctgtaa tcccagctac ttgagtggct tgaggctgca 44100 gtgagctgag atcatgccat tgcactctag cctgggtaac agagtgagag actgtctcaa 44160 aaaaaaaaaa agaaagaaag gaatgaaagg aatgtttaaa gtaccgcaga acatctcaga 44220 ataataggaa aacatgcctc acacacacaa aattcaaatc ctcatgctga ggcgtaagaa 44280 tgacttgaac ccaggaggca gaggttgcag tgaggcaaga tcgtgcctct gcactccaac 44340 aaatacagga tttgaatctg attatttcat ttgaatcagt attttagatc tgattatccg 44400 atatctgtgt tttagagctt gacgttaatt acaggtatct catcgcagca tgccgagggg 44460 aaagacaata gaatttgaag tgggcccact ggtgttccct cagccacgct gtttcctgca 44520 gaccttgggc tagtgattga aatgctctga gtctcaatgg ccacatctgt aaagctggac 44580 tatttccttc ctaggattat tgtcatggtt aaggaaggtg ggcagatgag aacccctagc 44640 ccaacgtctg acccatgcgt cactttcctt ctccccataa tcacagtaca aaagagttgt 44700 caacttgggc tttcaataga taatagttct cttgatctat ttgaaaataa tagtcaagat 44760 ttggctattg gctgcaaaaa tacagtgagg gagaaggaac aaggcccagt gttcaatagc 44820 atgtcacagt gactacagtt cacggtaagt tagtgtatat ttctgaatag ctagaggaaa 44880 agatttggaa tgttctcaac acgaaggaag gatcatgtgt gaggtgatag atggccggtt 44940 cccctgattt gatcatgaca tgctgtatgc ttgtgtcaaa atatcgcatg tacctctcaa 45000 atatgtgcca atctatccat aaaaattttt taaagatttg gctgctatta aaagagttgg 45060 tttcctgctg ggtgcagcgg ctcacacctg taatcccagc actttgggag gccaaggcag 45120 gcacattgct tgagctcagg agttggagac cagcctgggc aacacggtga aaccccatct 45180 ctacaaatag agtttaaaaa ttagccgggc atggtggcgc acacctgtaa tcccagccac 45240 tcaagaggtt gaggcatgag actcgcttga acccggcagg cggaggttgc agtgaaccga 45300 gatcgcacca ctgtatttca gcctgggtta cagagtgaga ctctgtctca aaaaataaat 45360 aaataaataa ataaataaga gttggcttcc taatttattt ctctgtgcat tgagttcgcc 45420 ttagtgagct ccctcgtgtg gggcgcagct ctgtgcactg gctctctgat gtctcacacg 45480 taactggctc tccccgctgc atttctacag aggatgccag catcaagcca aatccaccga 45540 cggcgagatt gaggcctata agaaatccat catgaaggag gaagaaaaga acgagaagct 45600 ggcgagcatc ctgaaccgga cagagacgga agccacactg ctgcagaagc tcaccaccca 45660 gtgcctgacc aagcaggtgg ccctgcagag ccagttcaat acctacaggc tcaccctgca 45720 ggacacagag gatgccctca gccaggacca gctggtgagg ccgggcccgc cccacaggtc 45780 acacctggcg cacggtggtg cctcttcagg cacgtgcacc ctgtggctcc ttgtctccag 45840 gaacaaatga tactcacgga ggagttgcag gccatccgcc aagccatcca gggcgagctg 45900 gagctcagga ggaagacgga tgctgccatc cgggagaagc tgcaggagca catgacctcc 45960 Página 103

P201430887 ES 2 553 786 A1 09-06-2014 aacaagacca ccaaatactt caaccagctc atcctgaggc tgcagaagga gaagaccaac 46020   atggtaggcc cctgccccag ggaggggctg tgcgaagccc cctgcagcct gggcatatga 46080 gggcaagccg tcctggaggc ggagagggcg gagtcagtgt gagcagaggg ccctcctgtg 46140 ctcactcctt tccatggtgt tcaggttgta agggtgatac atttttactg tagaaaacct 46200 agaaataggc caggcgtgag ccaccgcatg gccagctgcc agccaaaggc tgatttccct 46260 ggggggacct ggagtgtgac ttcgacgtcc atggcaggga acccccaatt gtgagctcat 46320 gttcgcatcc cctgggatct tgctttatcc tttatcacct gtggtggggg tggaggggac 46380 ttgtgtcctt agaaaaaaca attccttact tgaattgttt tttctttgcc tcttcccgag 46440 gggtgaccgc ctccccaaca ccccgcctca agcaggcccc tttggaggac ccccagaggc 46500 taccacaggc tccaccattt ccagagcaca tcctagcagt ggggcctgcc caacagtccc 46560 cattttagtc tcagaggagg gtgacagatt cccgatgcca agctctgccg gttttgccct 46620 cctgaggggt gggaaaggag ctggccaggc agagctgaag ggcgtggtgg gtgtgaagga 46680 gcccatccag ccgtgctgct accagccaag tccagttccc aatccccagg cccccgggcc 46740 cccgccgagc ccctgtctgg gcagcccgat aggtcatacg tgttttgctg ccagtttcca 46800 gaagagggca gcaaagagtc ttggaccaac acattcgtct attacgacaa ttttccaacc 46860 gatgccagtc cagctgctga aaagagtacc cccgacacga tgtttgaact gctcaaagcc 46920 tcatgggctg atagaaggtg gggtggggag gcatatctgg gaggaggagc aaagtgtgga 46980 tgggcgggac cacccatccg gagctggggt caaccacggg gtccaggcag ttaatccagg 47040 gatggtgtag atgcctaggg ggagccaggg tgggctccac agagaccaca aacagccagg 47100 agtggagcgg gggtgcaggc ccggctgtga cggggaggga ctgaagggga cttggagcca 47160 tagcccctgc agggcagttg gggagggggg aggcagggag tccttggggg gcccagatct 47220 cagggtgaac ttggcagagg aggaggctgc gagctgacat tgccacacaa ctccagatgc 47280 cggaagcttc cactccaggt gggcagggtc tgggttccac cacctgggga cattgggtct 47340 cctgggaagc cgcccgtggt ggccagtgag agacatggag cccacaggcg tggcgggagg 47400 agaagctcag atggccctga ggaggctggg gtaggcagga gccacagtcg tgagagagcc 47460 aaggccttgt gtggcaggag ccgacgggca ggggtgctca gggcagacac agggcccgag 47520 gccacctgtt agaaccatgc cctggggaag aggaccctgt cctggtggtg acagcatctc 47580 cctgttccca gagcagcttt ggccacacca ttgcagctgt gactgccact gcctcactcc 47640 tgattatcac aaacgtcctc tcgataaacc ccccgttgcc agaagggatc caaagtctgt 47700 ctaatgcctc caaagagccc acagaggagg ccagcactgg cggctcagac ctgccggaca 47760 gcaggagggg tcagaacgca tggaggaacc agtgtctaac aattgcttct tgcttcataa 47820 actatgctgc aaatgtgata gagtacagca cagccattac agcttacaga gcacaggaac 47880 ataagacccg acttaccaga ttaaaaagca ggttagcacc cagtgtgtag ggtgtgatcc 47940 tatttttatt ttggagaatt atatagaaaa gactgggagg aaaaatggat tcagatggga 48000 atggtagcta acttgtgtca gaattgcagg caattgaatg tgttctctgt cctggcctgt 48060 Página 104

P201430887 ES 2 553 786 A1 09-06-2014 attttcacat ttcctcacaa tgtgtgtgct acgatttaag aagtgtgtta gtctgatctc 48120   acactgctgt aggaaatacc taagactgga taactgataa aggaaagagg tttaattgac 48180 tgacagttct gcatggctgg ggaggcctca ggaaacttac aatcatggca aaaggcgaaa 48240 caggcacctc cttcacaagg cagcaggaga gagagtgtgt gtgaagcagg aaccgtcaaa 48300 cacacaaaac catcagatct catgagaact cactatcatg agaacagcat gggggtagcg 48360 gcccccatgg tccagtcacc tcccacaggg gccctccctt gacatgtggg attatgggga 48420 cacaattcaa gatgagatgt gagtggggac acagccaaac cacatcaata agaaaagcta 48480 ataccatgat ctctcttttc tgtaaaaagc caacatctgg gttccaacaa gtaggtccct 48540 tgctgggtcc tggagacagt gggaaatcca gcctcctgca ctcgtgactg tgcgtttgga 48600 atatctccag aggaacatcc cgaccgtcag ggaacggtgg atcagcaaac tcgtcccggg 48660 ccttgggtgg gggcaatatt cacaggtatt tcttttcatc aattcagatg acacatcttt 48720 ccaaaatcaa cggtgacatt gcccagacca ccctggacat cacacacacc agcagcaggc 48780 tggacgcaca ccagaagacc ctggtggagc tggaccagga cgtgaagaaa gtcaacgagc 48840 tcatcaccaa cagccagagc gagatctccc ggcgcacgat cctgatcgag aggaagcaag 48900 ggctcatcaa cttcctcaac aagcagctgg agcggatggt ctccgagctg ggggtgaggt 48960 cccaggcagg gagacgtggt ccccggctga ctgtggtgcc tggtggggca gagccccctc 49020 agatccccca cggtcagaca tgaactcctg gaaggcacag aactgcctct ttccctacct 49080 gctttacaga caaaatggca cgtgtgccaa gcgctctaag tcacattttt ctgcacaagg 49140 ccagagagta ttccggcttt gtggccagtt ggtctctctg gcagtgacac ggctctgcct 49200 ccatagcgag aaggagcata ggtaaaacgt aaaggaatgg gcacggctgt gtccaatcag 49260 atgttattca aggccactga agtctgaatt ccaaataatt ttcacccagc acgaaatatt 49320 ctgctgctct aagaaaagtg gcctaatgcg tttgaggcct gatgccatat acgtcatcca 49380 ggtccctgta ctctcaaagc ccctttgggt tccagaggcc ccacccaccc tgccagcgca 49440 cccaccatgg ggaagctaga gggggctcca gagcccctta gccatatttc ctccagcggg 49500 gtctgtggct tgcggccctg ctgagagcta acttgagccc ctcggccttc gtccagtttc 49560 atgacctcag ggttccaggc cctctgcagc ccactcacaa agacctttga gcccaagaag 49620 gctaattttg cttttttttt tttttttttt ttctgagacg gagtcttgct ctattgccca 49680 ggctggagtg cagtggtgcc atcttgctca ctgcacatct gcctcctgag ttcaagcgat 49740 tctcctgcct cagccttcca agtagctggg accacaggtg tgcaccagca cacctggcta 49800 atttttgtat tttgggtaga gacggggttt caccctgttg gccaggctgg tcttgaactc 49860 ctgacctcgg gtgatccacc cgcctcagcc tcccaaagtg ctggaattac aggcgtgagt 49920 cactgcgccc agccctaatt ttgctttttg atgaatatcc ggtctagggg gaagaagtgg 49980 ggcccctgga gcttgaaatc aaaaggctga gcaagctgat cgacgagcac gatggcaagg 50040 cggtccaggc ccaggtgacc tggctgcgcc tgcagcagga gatggtcaag gtgacacagg 50100 agcaggagga gcagctggcc tccctggacg catccaagaa ggagctccac atcatggagc 50160 Página 105

P201430887 ES 2 553 786 A1 09-06-2014 agaagaaact acgagtagaa agtaagagcc gccgtgcccg gccctgcagt gatgctgaga 50220   cgagctctgg gacgtgggca cctcccaggg gaggggcact cagtggggca cgtcgctgga 50280 tttgcacgca gccttaaaag caaataacaa acgcgcatgc tccctgtatt ttgtaaatgt 50340 gaaccactgc ctgcccagct gcccagttcg cagtcacagc gggagggttg agaaatgtca 50400 cgaaatggct ccaagctcac ggacttcaga gctctccttg agagaggagc atggaaggtt 50460 atcatccccg ccaagccagg gcactcaggt ggaaacactg gcacgggaaa agccagggtc 50520 ctgccaggca ggctcctggt gctgtcccca catcacctcc agttgggctt agaaaaccat 50580 tccaccgggg ctccccaacc cttctgaggc ccaaggggct gccaaagcac cagggtgcct 50640 ggaatgatgg aggcgggcat ccttcctgga ccactctcca cccacatgtc cacctgccga 50700 gacatcccgg gtcctgcccg gtcttgggtc ggggatccat gctggtcagg cctgcagcag 50760 agcccccatg ggaaatgctg cccagacaca tcatgtgccc ttctcggagg tcctgctgcc 50820 tctcgccctg cccttcttgg gttgcccaaa cccgtctgtt ggtgagtagc aagtcccaaa 50880 agaccctatg gagctgtcag ctgagtatcg gtgtcccaag gcaagagctg ccgaaatacc 50940 atgctgtgag atggggagga tcacccatgg agagggcaga gagaggggct cacatgccca 51000 tgtcctgggg tagtcagggc acaccatggg gacagcagga ggagctggag aagccctgtg 51060 aggagtggcc agcggatgaa ccagctgtgg cctcttgtgc cctccaccca tcttaacatc 51120 aagaagagct gttgttttct gcccctaccc ctgagcttgg ctggggcagg gcaggggtct 51180 aagggcctcc ctctcctgga gactcacagt gtctgagcat caaccaggtc ccggtgctcc 51240 acagatttgc aagtgtctgg gggagggagc ctggccctcc cacacgccct gcccacacct 51300 gctggctgtc cccacaggca ggtcctctca gttccgttgg aggaccaggc tttgggagct 51360 tagcagccaa aaagagaccc cctgtcctct cctctcctct gtcctggcag ggacgagatt 51420 caggcaggag cgccaggaac gacaagaggg aggggatgaa gggagctaca gggagagaca 51480 aaacctggct cacctctcgg acactgctgc ctgcgggcga ggacccgtac cctcctgggg 51540 tctctccctg agtctctgtt ttctgccata ggcaagattg agcaggagaa gaaggagcag 51600 aaggagatcg agcaccacat gaaggacctg gacaacgacc tgaagaagct caacatgttg 51660 atgaataaaa accggtgcag ctcggaggag ctggagcaga acaaccgggt gacagagaat 51720 gagttcgtgc gctcgctgaa ggtccggccg tgtccacgca gtcccggggc tcaggacgat 51780 ggagggcggg ggtacggtcc ttgcggtggg cgttctgcac caggatgtaa tttccacacc 51840 cgttcaagat gcttgtaggg gtattagaaa tccagcctgc agccctgccc tcggtgccgg 51900 gatagagggc accagccccg gcatccacaa tcccatggcc ctccccacag ctgtcccgcc 51960 ccctccccca tgcaggcctc tgagagggag accatcaaga tgcaggacaa gctgaaccag 52020 ctcagcgagg agaaggcgac cctcctgaat caactggtgg aagcagagtg agtcccagtc 52080 tccagccaca cgtgggtcat gaaggtcact gcacctacag gcctctgtcc gttgaagacc 52140 atgtaggagg ccaggtgtgg cagctcacac ccatatccca gtgctttggt cattttttgt 52200 tgttgttttg ttttttgttt tgttttgttt tgtttttaga cagtcttgct ctatcccaca 52260 Página 106

P201430887 ES 2 553 786 A1 09-06-2014 ggctggagtg cagccgtgcg atctcagctc actgcaacct ctgcctccca gcttcaagtg 52320   attttcctgc ctcaacctcc tgagtagctg ggattacagg tgcccgccac catgcctcac 52380 taatttttgt atttttagta gagatggggt ttcaccctgt tggccaggct ggtcttgaac 52440 tcctgatctc aggtgatctg cccacctcag cctcccaaag cgctgggatt acattcatga 52500 gccaccgtgc ccagcaatcc cagtgctttg ggatgccaag gcaggaggct cctttggggc 52560 caggagttca agacaagacg gggcaacaca gtgagacccc atatctacaa aaatgtttta 52620 aattggccag gcatggtggt gcatgccggt agtcccagct actcgggagg ctgaggtggg 52680 aggatcgctt gagcccagga ggtcaaggct gcagtgagct aggattgcac cactgcactc 52740 cagcctgggc gacagagcga gaccctgtct ctaaaagaag aaaaagacca cctgggcatg 52800 ggtctggaac ccaccctagt ggatcccaga ttccccacag agtctgtcta ccccccttgg 52860 tggcagttct tgagccaaac gagttactgc tagaaattga agggtttcct ttgtgataaa 52920 gtttttaagt atccattatt ttatggtgtc tgattattaa agtaacacac acccagctct 52980 aaacatttta aactatacaa tgcgtgcaaa gtacccaggg aaaattgcat ataattccaa 53040 cgcccttcac ttcccagaaa accaatgtgt agctatattc ctttcttgtt ttgctctgtt 53100 ttttacacaa atgggattgt ttcagaagtt cccccttgaa gcactttagt attttcatgg 53160 ccatctttcc gtgtcacaca cgtgggccca tatctccctg tggaaagggt gcggagcagg 53220 cgtggtgtgg aggcaccgtc ctttcttcag cgtgctccgg aagggatgaa tagcgcaggg 53280 atcgcctgtt ccttgcggtt tgatagaatc taggcaaaaa attatctggg accaatgctt 53340 tggggggctt gtatctttgg tgacatttaa atagctttta gactattggt gtattcaggc 53400 tttttacttt ttcttaagtc agcttctatc aattatactg actttctcag ctcctacagt 53460 tatatatccc tgttctctct ctctctgtct ctctgtttct tccccacccc catctccctc 53520 cctccccctg tatgccagag gttggcaaac gtttgcataa ggagcccagt agtgaacact 53580 tcaggctttg agagcctcac gctttctgtc gcagctgctt ggctctgcca ttgcagcttg 53640 agagccttgt aaagccttag agtgtgagct caccgaagca tcagaagaaa actcctaatt 53700 tcttacactg cctctcctac ctctaaagac accagattat gctttgggag aaaaaaatcc 53760 aactggcaaa agagatgcgt tcctcagtgg attccgagat cggccagacg gagatccggg 53820 ccatgaaggg cgagatccac aggatgaagg tgaggggagg agagcggcgt ggcagggcct 53880 gctgggtgcc agcccttggg ctctggagac ctggccacac caaggcctcg gctctcccgg 53940 ggctcctgtg ggaaccacac tggccacatt ggctggtggc aatgggtgag atttccaggg 54000 agcgacccgc tccagcagag tgacctgcac tccagccgag cactggcaaa gcgcacgtcc 54060 cccttgaccc agcttttacc acacgcttgc ttttaatgtg cagaaatatt gcagaacaac 54120 acaggacgca cacaggcacg tgcacgaaca acacgggacg cacgcaggca cgtgcacgaa 54180 gaacacggga cgcgcgcagg cacgtgcacg aacaacacgg gacgcgcgcg ggcacgtgca 54240 cgaacaacac gggacgcgcg caggcacgtg cacgaacaac acgggacgcg cgcaggcacg 54300 tgcacgaaca agggacgcgc gcaggcacgt gcacgaacac aggacacaca cagcacgtgc 54360 Página 107

P201430887 ES 2 553 786 A1 09-06-2014 atgaacaaca caggacacac acagcacgtg catgaacaac acaggacaca cacaagcacg 54420   tgcatgaaca acacaggaca cacacaagca cgtgcatgtc atctcacaaa acgctgtttt 54480 attcctactc catgtaatca cagcacgctg gtatttttaa atgccggttg taaccctcaa 54540 actttgtgac cctctaacgt atcccactgt gagacagtct cacaccacag aagggctcag 54600 agagcacccc catctcatcc ttcacagccg cgttgtctct ccatggtcac aattagattt 54660 cattgccttt aaaaggctgg taattaaatt gcaagtggtc atcaagctaa aggttcaggg 54720 ccttaaggat aacagtaaga gcagttcata aaataaatgg gcctcacttt caccatgcca 54780 tgctaaatag aaattcctct gctgagttat ttttcagatc aagtgcatat gctaataaga 54840 tgttgtgttt aaaaatacca aatttaattg acttttcata ttacagaagc cacatgtatt 54900 tgctggagca agacaagctc tcctccacag agtgggggcc aaagagaagg tccgggctgc 54960 tcctccctgt cccttcttcc ccggctcccc ctcctcagcc agggcgactg tgtcagccgc 55020 tgcagggata aggcctctca ccttctcgga tctcacacaa atgcacaggc agggcttgcc 55080 ttggccctac atggttacta acccattctt taacagttac aatatatact atggatattt 55140 cacaatttat tgatccagtc ccaggttggt gaaaattcag gttgtttcca atttgttgtt 55200 ggtgttattg ttttgtccta gacacaatgt gtgttagggt tctccaaaga aacagaacca 55260 gtagactaca cacacacaca cacacacaca cacacacaca cacacacaga gagagagaga 55320 gagaaagaaa gagagattta ctatgagaat tggctcttat gattatgagg gccgagaagt 55380 cctagtatcc ggcatctaat ctgcagaccc aggagagccc atgattcagt caagtctaag 55440 acctgagaag gaggcaacgg tgtcatccca gcccagtgtt cccccacccc caccccgtcc 55500 caccaccttc ttctgccttt tctcctcagg ccctcaacag attggatgat gtcacccagc 55560 ctggcaagag ggatctttac tctgttcaaa tgccaatcat ttccagggac accctcacag 55620 ttctacccaa aacagaaatc atgtttttcc agctatccag gcattcctta gcccagttag 55680 gttaacccaa aatcagccat cacacagcat tataatcaca tccttcctta ctggttcttt 55740 tttttttctt ctagactatg ttcccaaagg tgagattact aggtcaaagg gtgtataaat 55800 tctgactgta acagcctgac agattacttg tctaaaaagc acatggcggc agtcatatct 55860 gtaccttctt ctcagttctg gtgttattta tctatctttt ttttttttta attgaggttt 55920 ttcagctgag tggaagctca cagcttaggg cattcagccc tataaggatt ttctgggttt 55980 ttttgttttg ttttgtctgt ttgttttttg ttttgtcttt gagacagact ctctgtcatt 56040 caggctggag tgaagtggtg ggatctcggc tcgctgcaac ctccgcctcc caagttcaag 56100 cgattctcct gcttcagctt cccaagtagc tgggattaca ggtgtgtgcc accatgcctg 56160 gctaattttt ttgtattttc agtagagacg gggtttcgcc attttgccta ggctggtctc 56220 aaacttctga gctcaggcaa ttcgcccacc tcagcctccc aaagtgctgg gattacaggt 56280 gtgagccact gtgcccagcc agccctacaa gttttgatag agacgtacaa tcatgtagcc 56340 actgccacat catgatatat ttcctcatcc tcgaattccc tcatgccctc tgtagtcagc 56400 tcaccgcata ccccagccgc catgacagcc accagtctct ctccatgcct gtcgttttgg 56460 Página 108

P201430887 ES 2 553 786 A1 09-06-2014 cttttccaga atgtcacata aatggatcaa atagggtgag acatattgag cctgactttc 56520   cttgcttagc ctcatgcatt tgagattctt ctgtgtggtg aagcccaatt acccagtctg 56580 ttctcttttt ttagagacag ggtttcgctc tgtcacccgg gctggagtgc agtggtgcaa 56640 tcatggctca ctgcagcctt gaccttgtgg gctcaaagga tcctcctgcc tgggcctccc 56700 aaagtgctgg gattacgggc acacaccacg gcacccaccc ctcagtctgt tctttcatgg 56760 atcgtttcag tagcttatct gaggagcctc tgcctagctg aaggtcacga agagcttctc 56820 ttctgttttc ttctagaagc ttcctgcttt taggttttac atttaggtcc ataatgtatt 56880 ttgagttaat ttttgtgtat ggtgcaagtt gtggactggg gttaattttt tttgcatttg 56940 gatgtccact ggagtcagcc ctgcttgctt cctgaaaaga ctgcccttcc tccaccgaac 57000 taccgtccag tccttgttga aatcagctga cacgtttgtg tgggttcgtt tctgggctgt 57060 tttgttctac tgatttctgt ttctgtccct tcaccaatgc cctgctgtct tgatttctgt 57120 aactctatac ttacgaaatt cctccgactt cctttttttt taagacagag tcttgctctg 57180 ttgtccagac tggagtgcag tggcactcac atctcagctc gctgcaactt ccacctcctg 57240 ggttcgagca attctcctgc ctcagcctcc tgagtagctg agactacagg catgtgccac 57300 cacacccagc taattttttg tatttttagt agagatgggg tttcaccatg ttggccaggc 57360 tggccttgaa ctcctgatct cagatgatcc acctgcctcg gcctcccaaa gtgctgggat 57420 tacaggtgtg agccactgtg cccggccagc tgattttaat attaggctgt tttcttattt 57480 ctcttttttt tttttttgaa acagtctcgc tctgttgccc aggctagaga gcagtggcac 57540 gatctcagct cactgcaacc tctgcctccc ggggttcaag tgattctccc gcctcagcct 57600 cctgagtagc tgagattaca ggcgtgcacc actatgcctg gctaattttt gtatttttgg 57660 tagagacggg atttcaccat gttggccagg ttggtctcaa actcctgagc tcaggtgatc 57720 caccggtttc ggcctcccaa agtgctggga ttacaggcgt gagccaccgc acccggcctg 57780 ttttcttatt tcttaacatt ttttaggagt tccttataca ttcggttatt aacccctgtc 57840 ttcaatacct attaaaatag tggctctgac ctatcattgt ctttgccctc tgtttagggg 57900 gtcttttgcc acacagactt tttagtgttt cttagtgtgg ctccaagtca ctttatggta 57960 cattttaaac ctgagtaagc ttggtctccc ttcaccctgc ttatcttcgg gattcttgcc 58020 tgttttttct tttaaatcaa ctttaggcat aactttcata agataaaata tgcttatttt 58080 aaacgcagag tttgggctgg gtgcggtggc tcacgcctgt aatcctagca ctttgggagg 58140 ccgaggcggg tggatcactt gaggtcagtt caaaaccagc ctggccacca cggtgaaacc 58200 ctgtctctac tgaaaaaaaa aaaaaaaata gccaggcgtg gtggcaggtg cctgtaatcc 58260 taactacttg ggaggctgag gcaggagaat tgcttgaatc tgggaggtgg aagttgcggt 58320 gagacgagat tgtgccatcg cactccagcc tgggcaacag aaggagactg tgtctcaaaa 58380 aatttttttt ataaaaaggc tgggtgcagt ggcttatgcc tgcaatccca gctttgggag 58440 gccaaggtgg gcggatcgag accatcttgg ccaacatggt gaaaccccat ctctactaaa 58500 aatacaaaaa ttagccaggc ctgggggcag atacctgtaa tcctagctac tcaggaggct 58560 Página 109

P201430887 ES 2 553 786 A1 09-06-2014 gaggcagaag aatcacttga acccgggagg cgaaggttgc agtgagccta gatggctcca 58620   ctgcactcca gcctggtgac agagcaagac tccgtctcaa aaaattttta aaaaagcaca 58680 gtttggtggg ttctaacacg cgcacacatc tacgtagcca ctgacgccat caagacatag 58740 aacctttcta tgactccaga aagttcctgt gcacccccgc agccaatcct cacgctacaa 58800 cccagtcccc agccccaggt cctccaccca agccaaggtg cattgtcaca actaagaaat 58860 taaccttcat gcaatactgc taaccaaact acaaactcta atcagatttc accaattttc 58920 tcaatgagat ttttttctgc tgcaggatct gaccctggct tagttgcttt tagttctcac 58980 atctccttgg tggcctcagg tctcggccat ttctccacct tgcactgtct gcctgtggat 59040 tccgggttcc cacccagggc tgctgcctcc atgtcccttg ttcctcctgg cggcacaggc 59100 ctcactgttt ccccgccgat ccccatgcgt gtcaccggag gatgagcgag gccagcgccc 59160 cggccactct ctctgcagct gcagctcagg cctgccccag ccccagcccc tctgtcctgt 59220 ctcccaggtc aggctcgggc agctgctgaa gcagcaggag aagatgatcc gtgccatgga 59280 gttggcggtt gcccgcagag agaccgtcac cacccaggcc gaggggcagc gcaagatgga 59340 caggaaggcg ctcacccgca ccgacttcca ccacaagcag cttgagctgc gccggaaaat 59400 cagggacgtt cgcaaggtag ggagcagcgg aaaggaaaca gggcgcctgc tcctctctct 59460 gggattcaag gaacactcca ggaaggcgtc ttgctgggtc cggggtgagg atgcagaggc 59520 tgcagtgggg gcgtgctcag cactgctaac ctgctgctgg gtgctgggtc tggggtgagg 59580 atgcagagag accatcccca gttctgctaa cctgctgctg ggttcggggt caggggtgag 59640 gatccagagg ctgttagagg ggcgtgctca gcactgctaa cctgctgctg ctacggggcc 59700 tgtctgggag actgcagaat gcccgcaccg gacagagctg ctgacaccca gagacggccg 59760 tgtttcagcc cctccctgca tatcggaggt ggcattggga aggcatagag ttctggggaa 59820 gaggccagct catgctgggg agcccgagtg ggcaccgggg accagctgat gggagcgggg 59880 tgggcgcctc gagagcctgc atccgcatac cccaggccat gtccactggg cctgcactgg 59940 gagggcccag ctggtgctgt ccggtgctta ccacctcaac ggttgccagc caggggccct 60000 gcactcacac ttcccaggtt ggccccacag ccccgctgac ccgctgtgtg acctcggagt 60060 atgtgggcct tgccagacct gcagggcctc gtctgctggg gggtggaggg gcagagttaa 60120 atgtgacagc aaccacagcc gtgggtgggg aggtggcctt ggggacagct gacagcatgg 60180 cttggagcca cgctggacca ttcctgactg gggcatacgg tctgacctcc cagagccttg 60240 gtttactgac ctgtgaaatg ggtgcccacc tctcagagtc acccagaggg ttccctggag 60300 agtgctgaag tcatccctgt agggaaaggc tagccaaaaa tggcagacat gcatgggctg 60360 ctcatttgga agtaactgga agtttctgga gagaggcggc agagtggcct cttctcagtc 60420 cttttccact acattggcta ctcctgatgt ccatccctcc ctcagcttcc tagcccggcc 60480 cctgaccact ccttgctgcc ctgggcaccc cctgagtccc ctgccaggac cccatgccca 60540 cccctcacct cctgtctgct ccaagccaca ctcaagttct ccagccccag gccctgcgcc 60600 ccacacgacg ccatcactga tgggtccttg tcctcacccc tgccagcccc accccaaaga 60660 Página 110

P201430887 ES 2 553 786 A1 09-06-2014 tcttccgtgt ccccagccag ccctgagagt cactgtgtct cctgcatcac cccctggacc 60720   atgtcagctg ccaaacactg cctgcccggc ttttctttct cttaattgtg ctgctttccc 60780 cgaaggcgga acgaacacca cacagatggc cccagcctcg ctcctccctc agcagaggcc 60840 cccaccctcc tctctcccag gctccccagc ctgcctctcg gcccttacag cctcagccct 60900 gcccttggca cacggctgct gaactgtgcc agtctcctgc ctggggacag acccactgca 60960 cggggagccc cagaaccact caggccccca tctctctgcc acacctgcct taaaggagca 61020 gtgtgcagtg tgggctggct gggcctggca tctcccaggc ctcgcctctc cagccctccc 61080 attcctcttt gggagcctcc ctggatggag tgtgtggaag gtgcctggca ggtcctccca 61140 gcctgactct tccctgtccg ccaagtagcc gggctgcagg ggcccagcat ggtcctgtga 61200 ttctcctagg ccaccgatga gtgcaccaaa accgtcctgg aactggaaga aacacaaaga 61260 aatgtgagca gctccctcct agagaagcag gaaaagctgt cggtgattca ggcagacttc 61320 gacacactcg aggccgacct cacccggctt ggggccctca aacgacaggt aaacgtgtcc 61380 caggaggtcc ctggggatga cggccatgga acatgccact cacacagagg tcctgcgtcc 61440 cctctgtgcg agtcacggcc tctcctgatc aggtcacggc ctctcctgat cccaggccag 61500 taatagcacc accggctgct cacatgtttg tggctttgtg atttgttcca ctgacaaatg 61560 ttgatggagt atctgttatg ggctgggctc atgttcagcg tgcgagggtt acaaaataga 61620 acacaaaaaa caaacattcc tgtgctctta gaggttacct cctggggcag gaggacagat 61680 gatgagcaaa ataattttaa aagatacagt gtgttgtagc taggcatggt ggtacacacc 61740 tgtggtgcca gctactcagg aggctgaggt gggaggatcg cttgagcctg ggaggtcgag 61800 actgcagtga gccaaggttg taccactgca ctccagcctg ggtgacagag ggagatcctg 61860 tctcaaaaag aaaagaaaag aaaagaaaag aaaagaaaag aaaagaaaag aaaagaaaaa 61920 gggaaatggt gtgttaggtg gtggtaaatg ctttgaagga agataaacca gagaaagaag 61980 cgtcagggtc attggggtga actgagggat tgacattttg agttagggtg atgcgggaag 62040 gccctgcgga gcagacattg gagtccagac ctgaaggagg ggacagccca caaaaccacc 62100 ccaggtggac aggacagccc ggcaaggcag aagcctgaga ctgcgcaagg gctactagag 62160 gccagtgggg caggctgggg aggttagggt atgtaagacc caggcagaga ggggcggccc 62220 agactgtgtg cggccttagg gagagcacaa tcatgacttt ggacttttct cttggggagg 62280 tgggcacaca gaggagggcg ttgggtctga gaggtgactt gggctttagc gggctcccgc 62340 gcgctctaag attgcatgtg gatgaagcat ggatgcgggg ggcacctggg gctatttgca 62400 gtgcttcagg gcggcccctg tggggctggc gagaagccat caggctctgc atatgcgtta 62460 tgccaacatc gcccgatggg attcctgctg ggttggctgt ggtgtgagca gagacggagg 62520 tggagaatgg ctccaaggtt ctggcctggc caactgagat gatgagggga acgtgcctgg 62580 cactgggcct gacacacggc aggtgtcaag aaggttgcct aagccgggca cggtggctca 62640 tgcctgtaat cccagcactt tgggaggccg cagcaggtgg atcacttgag gtcaggagtt 62700 cgagaccagc ctggccaaca tggcgaaacc ccatctcaac taaaaataca aatattagcc 62760 Página 111

P201430887 ES 2 553 786 A1 09-06-2014 aggcatggtg gcgggcgcct gtaatctcag ctacccgggc gtggtggtgg gggtgggtgc 62820   ctgtaattcc agctagttgg gaggctgagg caggtgaatc gcttgaagcc gggagccaga 62880 ggttgcagtg tgccaagatt gtgccattgc actccagcct aggtaacaga gcgagacagc 62940 ctcaaaaaaa aaaaaaaaaa atgccggcgg gtcacagtgg ctcacacctg taatcccagc 63000 actttgggaa gccgaggcag gcggatcacg aggtcaggag atcgagacca tcctggctaa 63060 cacggtgaaa ccctgtctct actaaaaaaa aaaaaaatac aaaaaattag ccgggcctgg 63120 tgacgggcat ctgtagtccc agctactcag gaggctgaga caggataatg gcgtgaaccc 63180 gggaggcgga gcttgcagtg agccgagatc gcaccgctgc actccagcct gggcgacaga 63240 gcaagactcc atctcaaaaa aaaaaaagaa tgcctcctag atggtgatga tgggtgaccc 63300 ataaagcacc gacccagtgc ctctcagcct cttccctgag atccaggggc gcaacacctt 63360 cacgccgtcc cttttcaggc gtaggtctcg cctcctcttc ggcatttcct ggaatctgag 63420 tttgtggggg gccagcaggt gtctttcttc tggtttgcat agccctatat ggagtctctt 63480 ttcctaccca gaacctttca gagatcgtgg ccctgcagac acgccttaag cacctgcagg 63540 ctgtgaagga ggggcgctac gtgttcctgt tccgctccaa gcagtcccta gtgctggagc 63600 gccagcgcct ggacaagcga ctggctctca tcgccaccat cctggaccgc gtgcgggacg 63660 agtaccccca gttccaggag gccctgcaca aggtcagcca gatgatcgcc aacaagctcg 63720 agtcaccagg gccctcctag ggagcagcct ggactccgcc ttgcaaggcc tccaggaaga 63780 gatccggaat tgtgtttgtc atgagggact tggaatcttt tgtgttccta aaaaccacat 63840 gtaccctcag aagggcatcg tttaagagaa ataagccagc cccacccata ggaatctttt 63900 tagccactca gcaatttaat aaaccaggta aaatcctagc gtttcccatg gcatcccatc 63960 gcaaagacag agcctgtgac tgcagaccca cacacccaca ctcccacact gggcttactc 64020 gtccaggtaa cactttggtt tgcagcactc ccaaatctgc acgtgcctct cacaacacaa 64080 cgctgccaca ggtccacaag ctggtgggct gagcagaggt gggaaagtta aggcagctcc 64140 agccagcctg gcccgggagg ctggtccccc cagcacttcc ctctactagg tgcatctgaa 64200 aacccacaaa ccaccttctt taccagtttt cccatcccca ccccttagaa ctctcaggtc 64260 ccttttcctg cccccatgtc cccatttgag ttaaattcag atccacagct tgcaggagaa 64320 agtcagtggc cccagacaca cgtaacaggg tgagcactga aataagagca cgctggggcg 64380 tccacaccaa gggactacgc cccagtctgc ccacctatct tttctccatc attaacccag 64440 cgctctttct ccctggactt ccaagtacca atgaccttgg ggcttctttg cagtttaaag 64500 ggaaaatgct ctacaaaata atttcacttt caaacatttc agcagaagaa taaaatcttt 64560 tttctgaata tctagtaagc ctttctgagt cagccttact tattttaaaa cattgtagaa 64620 atacagaaac cacaacagag gtggaaggga ggcttttgtt tttttttttt tgagacggag 64680 tctcgctctg tcgcccaggc tggagtgcag tggcgcggtc tcggctcgct gcaagctgga 64740 aagggggctt ttaatgcccc tatgccccta cccaggaaca acacctctgt gttttggtgt 64800 ggctcctttt gtatttttct gcacatacat tttattaggc aagttaaggt tatactgtgt 64860 Página 112

P201430887 ES 2 553 786 A1 09-06-2014 gttttttgta tctcacatgt aaaaatgtgc tcctcttaat gtaagcattt tctcatttta 64920   tgaaaaaatt ccccctgtgt cagtttaatg ttttctcaat tgtcagtttt atgggttatc 64980 acaatgtttt gattattcct ttctggaata actgtgagtt atggagcaca cttaaggact 65040 ttccaaatgt tggctgtttc taacttggcg ctgagcgcct ttggccgcct ttccgatgat 65100 gccctcggga cgcgttggca ggaggaatcc ctgggcgcaa ggcgcggctg ggccagcccc 65160 ttacaaagcc ctacgagc 65178 <210> 10 <211> 4113 <212> DNA <213> Homo sapiens <400> 10 cttctgtcaa aaacatgtgg ttcagaggag gagagagatc caggtcaatg tttttcaaat 60 tacaaggaat tatcatttaa atggggttgt tgctcaagtt ttgacgtgta gtggaatgga 120 gtggagtgga gtggaatgga aactaacaga aaacactgca catggttaag ataaagattg 180 tttcctgaaa cctttaattt gtgcttacat actcacacat acatatgtgc atgcactggg 240 actctgcaat atgcatttct gactatggaa catagccata aaagtctttg cactgaacgt 300 tcagtgggcc tttcacaagc tgccctaatt gggaaagaaa aacatggtcc ctccatttcc 360 tgcccccaac tccagaaaag tcaccatagt tgagggtaca tctgagaagc cagcacttgg 420 gagttcaggg ctcaagttcc tttctagaaa aacactgggt gattctaggg gaacttctga 480 tcagaaacag ccaattcaga gtgagagaag aaaacgtgac catgcagttc ctgtggttac 540 cagccttgcc cctctcttgc cttctgggag ttataaaacc caagactgga aaggaaaacc 600 agcatttgct caggcagcct ctctgggaag atgctgcttc ttcctctccc cctgctgctc 660 tttctcttgt gctccagagc tgaagctggt gagtatcagg gttcttccct ctgaaatctg 720 cagtatcagc tcctgaaaca aagatgttta gtctgaaaat agctgactcc taaacagggt 780 tccaagatct ctcttcaaga gtcccagagg gaaatttcca cttgggatgt gtgccacccc 840 acccccaccc ccacccactg ccattctcta cagcctagga cagcccccag gaacaaggaa 900 tttcacctca attgtagaaa agcccagagc aagtggaagg aaaaggggta tccccaggaa 960 aacagacatg tcctcttaat cttctgagca tcagggctac ccattacttt gtgactttct 1020 cactctgtga ccatgctcaa gagctatgga gaaatctaaa acaggaacct ggacagtggg 1080 tcctacacag agacagagga gggtgggcca gggcaaggtg ggagtgggag aagtctgaga 1140 tgaaaacatc agaatggagc agaggcaaga atgagatttc acctgggagg ttatgggtgg 1200 ggaaagatac gaaatacagg agacaggaga gggaagatgg gcggaacaca gggtgagaat 1260 gagattccag ggaagcctag ctcagcttta acccaatttg tccattcatt ggagagagta 1320 tctatggccg tgttcaaacc ctggggtgct ctgttccagg ggagatcatc gggggcacag 1380 aatgcaagcc acattcccgc ccctacatgg cctacctgga aattgtaact tccaacggtc 1440 cctcaaaatt ttgtggtggt ttccttataa gacggaactt tgtgctgacg gctgctcatt 1500 gtgcaggaag gtgagacaac agggtctatt tatctccaaa tgggagatga acaaccagag 1560 Página 113 tagcatccag gaatacacct gcactgggga ctgaagaggg ggtcctgggt cttgtcaact 1620 ttcaggagag ggaagacttg ggctgaaaga ctttagtctg tgtttgaata gttccttgag 1680 cctcagtcac tgtgagctaa gctccccttc ggaggaaaag gaggtcctgt ccaaggtccc 1740 tcttgttgca gtagcacccc tcacccctac ccaactcaag acacacggct cacttttcag 1800 ggccccaccc agtctcaggg ccacttcctc tatggccttt tcaagaacac tggcctctag 1860 ttctcagggt cctgaaccca tcattttatg ggaggcagag aacagggtct acatgagacc 1920 cccactttcc cgtttaactg atatctcctg cttcaggggc tggccctcat gcagggttcc 1980 ctgaattagg aagtgtgaac cctgtcccct gagtcctccc tggcctgttc agtccccagc 2040 aattccaggg gtcgtagaaa ttgtgtctgt ttcctgagaa agctctttca tgagttaagc 2100 ctgagccctc aaatgccaca agtggcccat gaaaagggag atgggtagag tccggcgacc 2160 cagtgacaga gtttagtcct cttttctcag aatgagctca cctcagaaga aaccccaagc 2220 catcactgtc gctccttttc cttccttctt cctcacaaca ggtctataac agtcaccctt 2280 ggagcccata acataacaga ggaagaagac acatggcaga agcttgaggt tataaagcaa 2340 ttccgtcatc caaaatataa cacttctact cttcaccacg atatcatgtt actaaaggtg 2400 acaacacctc tcttctccct ttccacttcc cattctccta agcttctcct tcaggtcctc 2460 attgccctga atttttctta ggacttggct ataacatgaa gctactcacc ctgtccctcc 2520 ctgatcacct ccaactgtcc agagcccatt tcgaggactg acagtccttc attcccttca 2580 cagttgaagg agaaagccag cctgaccctg gctgtgggga cactcccctt cccatcccaa 2640 ttcaactttg tcccacctgg gagaatgtgc cgggtggctg gctggggaag aacaggtgtg 2700 ttgaagccgg gctcagacac tctgcaagag gtgaagctga gactcatgga tccccaggcc 2760 tgcagccact tcagagactt tgaccacaat cttcagctgt gtgtgggcaa tcccaggaag 2820 acaaaatctg catttaaggt gatcctccaa ctaggtttcc tctccaaaac tcactgttca 2880 gggaccagaa tgctcttaga aggagatggg gtcagaaggt tgtcagtcag tgacagggtg 2940 agcatcacag gaattgctgt cctcccgtgg tccaagacag cctctgacca tccattccag 3000 tctactgcac tgggggcatg gggtgatgtg gagaatgtgg atgacggtcc caagaaagga 3060 agaaggggca tcagaactag atgtataagt gaggagctcc acctcctgcg tctgacttta 3120 ggtctcactg tgactccaag ctggctggca gacaggagtg gaggacttcc cgggctcacc 3180 ttcttctctc tctcctcccc ctacagggag actctggggg ccctcttctg tgtgctgggg 3240 tggcccaggg catcgtatcc tatggacggt cggatgcaaa gccccctgct gtcttcaccc 3300 gaatctccca ttaccggccc tggatcaacc agatcctgca ggcaaattaa tcctggatcc 3360 tgagccagcc tgaaagggaa gctggaactg gacctgagca gcaaagtgtg tgccactcat 3420 tctggtctac ccttggtccc tcagccacaa ccctaagcct ccagaagtat cctacaggtc 3480 acagaactct caataaacct cagtgaagac acagcttcta gtcgtgagtg tgtgtcccct 3540 ctctgctgct ctcttctccc tgcacatagt gacctgattc ccagcccaag cacccaagga 3600 tttggaaggg gtttgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtatgg 3660 Página 114 ggggggaggg agagagagag agagagagag aaatagagag gaattaatga agaaaaaaaa 3720 atgaggaaaa agaagagatt ttccctggaa aggcaggatc catatttcca gcttaagaaa 3780 agacaccaaa tccttctttg ccttaatcat caaccctata ccaattctga tttatcttta 3840 gtaatattca gaagcactaa gaacattttc aattataagc aagatataag atgtttacag 3900 catccctggc ctcttcctac tagatgccag aagcaacacc cccttctcca ccgcaaagtt 3960 gtgacaacca aaatgtctcc aggcattgct aaatgtcccc aggcgaggga gggaggagga 4020 aagaaagatc actgtctttc gttgaagacc actggctctc tttcgttgaa gaccatggtt 4080 tagatacatg atataaagaa ggcagctgat gcc 4113 <210> 11 <211> 74718 <212> DNA <213> Homo sapiens <400> 11 ccgggggcct cacctgctgg aggagcaact gcaggagaag cacctgttag gggccgcacc 60 tggccggagg ggctcctgcg ggggaagcac ctgcccaggg tgcacctacc gtgtgcaggc 120 tgcggaccac ccggacaggt gccccctcgg cagggagggc ggtcacgggg gccggccagg 180 tcggggtggg gtcctcccgg ggatccagac acggccctgt ggcctctccc cgccccaagc 240 ctttcctttc tctccccctc tctctcttcc tctccttcct ccttcccaca acaccgcccg 300 ctcgcagcgc cccgccctct cctggaccgc gcactccctc cgcggaggcc ccaggacgcg 360 cacgagcgcg cagtggacgt cggcgcgcgg accgggcatg ggttccccag ctgtggcgcc 420 ccgcgtgcgc gttccgtagt gcccggtagg gcactgggct tagctgctcg aggccgcgcc 480 ctaagaggcg gggcatagac aggaagaaga ctggcgggca tgtgggcggg gcatgatctg 540 gaggcggggc gggccgggcg tgtgggcgag gcccgaggct cgcggcgccc cagctctcgc 600 gagagcggcg cctgatgacg accgggaggg cggggcccgt ctggggcgcc ggcgggtgcg 660 tttgaatctg gtccgagcgc gggaaacggc gggtccccga gcccaggtaa gagctgcggt 720 gccgagccgg gattgggttc agagcagggg ctgggaagta gcagggatcg ggcgggaagc 780 ccctcctcgg ctggtcgggg tcccagcctc ccctccccta aggaggcggc cgacctgcgt 840 gcgggcagtg ctgcctctga cggaactgga cggaactggc gaccccgggc catcccccct 900 acccagctca gcgacgcccg tccttcttgt ccgtgtcgga ggaaaatccc agccccgggc 960 gcgggcactg ccctcagaga gcgacccccc agccctgagc atgggcaccg tcctcagaga 1020 gtgtcccctc agtcctgggc atgggcactg ccctcagaga gcgacctcct ctgtcctggg 1080 catgggaact gccctcagag agtgtcccct cagtcctggg catgggcact accctcagag 1140 agcgaccccc tcagtcctga gcatgggcac tgccctcaga gagcgtcccc tcagtcctgg 1200 gcatgggcac taccctcaga gagcgacccc ctcagtcctg agcatgggca ctgccctcag 1260 agagcgaccc cctcagtcct gggcatgggc actgccctca gagagcgtcc cctcagtcct 1320 gggcatgggc actaccctca gagagcgacc ccctcagtcc tgagcatggg cactgccctc 1380 Página 115

P201430887 ES 2 553 786 A1 09-06-2014 agagagcgtc ccctcagtcc tgggcatggg cactgccctc agagagcgac cccctctgtc 1440   ctgggcatgg gaactgccct cagagagagt cccctcagtc ctgggtgtcg gtactgccct 1500 tagagagagt ccccctgagc cctgggtgta ggcactgccc tcagagagta tctccccagc 1560 tgtggacgtg ggcattgtcc tcagagacat cagtctcctg aactcttgtt gctggtttgg 1620 tgcctcttgt tgtgtccatg aggaaggagt ttggggacgg agtgggaagt cacaggtggt 1680 gagaaggtaa cagggatttc ttctttttaa tgctcatctt gatttagtac cagacctcct 1740 gtgcgaagag taacctgctc ttcggactga taactggatg gtgagatgac tccttacctt 1800 gaaagtagca ttctggctgc agggctgagg tcttatgcac atatggtaca agaaacatgg 1860 aatattgcca ctttgggaga tagattgaaa aattaaccat taaaaaatta cagtcactaa 1920 tataagaggg aaaatgggaa atataggaat aagtttggta gtctagagga agtgtattac 1980 tgtaagttgg actaacatgc caaagaggta cacttggaaa tagagcaaac aagaaaagtg 2040 accagaacta tgaaaaagtg gagagtgttc acagacttgc cgggcgaaga tgtatgattc 2100 catgtgtttg ctgcacctta ttggattatt tttctaaaat catgaatttg tcctagccac 2160 tattcattat gcttgttact ggccactctc ccttccctcc ccattttctt tgtcagtgaa 2220 aaatgtgcca gtcatgcttg atttaaagag ggagacacgt tgtcgttagg caatttcatc 2280 attgcatgaa catcacagag tggacttgcc tacacctaga ggtgtagcct acacacatag 2340 gctgtatggt gtagcctact gctcctagaa tgttactgta ctgaatactg taggcaactg 2400 taatacaatg gcaagtattt gcatcgctaa acatatctaa gcatagaaaa agcacagtaa 2460 aaatatggca ttataatctt atgggaccac ggtcatacat gtggtctgtt gttgactgaa 2520 atgttatgtg gtccatgacc gtagttcata gttcagccat ttgagttgag gaatgagatg 2580 accagacttc actgttaact tatttcggga gtcattaaac tgaggttatt tttgctttgt 2640 tcaatttgga cattaaaatc tagtattata tgtttaagat gactctctgt ccccataatt 2700 attggcaata attttccata ttgctctatt tataatggtg caggtggttt tcatttattt 2760 ttaaagtgag ggggctccta ctgcaaatgt gttccatcat ttgctattac ctcatcttta 2820 ggttgatgtt ttttcagtag ggcaccagta gcaccaggta ttgtgaatgc gaaatagaat 2880 ttcctggaaa aacacaggca ggatggaggg tatacaaagt cccctgagct ctcattatcc 2940 cgaaggggtg ggaggagggt gctgtggttg agcatgccta atgcatagtc taacaagatc 3000 ccaggtgacc cccggggcca ctgttttcca tctcactttg aataacaaga tgacactaac 3060 agtgggattt ttttgatgga ggaatggcct ttagaaaggg agcatcttca gaatctgcag 3120 ctgggatcag attgttcttt tgttgaatca actcagctct gccgagccag catcttgcta 3180 aggtactaaa aagggagaga tggtggtgag cttcctaagg ctatttggat ttctccctcc 3240 ttagttggta attttattaa caattgttga taaaatatca ttaatatcat gttattcaca 3300 tccccagtaa aggaaataag taaattgttt ttcagatatt atagcgtgtt ttatgtcaga 3360 atgtttttag aaactgtctg ccatacgtgg ttgaggaatt ttcttgcagt tcttggatgt 3420 taatatcaaa ttaaatctta caggaaaaga tatatttgca agtgtttcag tatgattgtg 3480 Página 116

P201430887 ES 2 553 786 A1 09-06-2014 ttttccatta gggttacaaa ataaatgcca tttgaacagt gccatctgtc atggaaaaac 3540   gtgagacgtt tgtacaagcc gtgtctaagg agctggttgg agagtttttg caatttgttc 3600 aacttgatgt aagtttcatg ttttagtttt gttgtgattt ttgactgtga atatgaaata 3660 tgttctaaag tcattatgtc cccaaaagaa acatagttat ctcagtgaat ccttagcgac 3720 caatgtttat ttgaaagaag aaaacaaaac cctttatact caaatctacc tgctggtggg 3780 ctacgctaag atgtaaaaga taaacagaag ttaaccagtc aaagagggat gttgggggaa 3840 aggacccatc taacaaagaa ggtcactctg aagactagag aaggtttgtt gtgtttgaac 3900 ttgaagttca gcaggaaggc agaagatgag gctgggggct aggctacacg agtctttacc 3960 attttaagga attcagactt tatcttgaga acggtgggtg cttgaagcag ggagcgagct 4020 gtaggcaagg gaggaagaga acaaaagaga aggagagaga actagtggac aaaatagagg 4080 taaggagaaa aatatggttt gccttttgga aatattcctc tgactacaag tgagaaatat 4140 gtcaaaggga catatttaag gctaacctct taggttgtgc tcttcaaaat gatggttgaa 4200 ttaggaactg gaaatgggaa gctgcttggt agtgaagtga tggcactatt ggactgattg 4260 gatatggata tggtggggaa gggcccaggc gtctgactgt gtagtaccat tcagcaagct 4320 catgaacgtg ggaagagggc agattcaagg gagaatgtgg ctccattttg gaggtaccag 4380 atgactggtg gtgggatgtg caccagcgga tggccagtag tcagacatgc acgtctggat 4440 accaggggaa agggctgagc tagagacagg ttgggcatgg aagcctaagt catgggaatg 4500 cctgcagtta tctctgtaga gtttcagata aaagggccta ggacacatct ctgaggaagc 4560 cagcattgga ggcactgact ctgaaatacg aaagtatctt tggggcagga gacccttggc 4620 acacttgtct cacttgttct tattatgtgg tgaaaatcaa attagtgaca aagaattaga 4680 ggaatctaat aatgaatttg ttactggcaa catttaagaa atcatttttc tttataagag 4740 aaatgagctt ataacatgtt ttggtattat aaaatgatat cctgtaaact taaaaataat 4800 cgcaaactca taggcatctc atcaccatag aagtgtttat aagagcaaat tagttagata 4860 atatataaat gtctgcttta gcagtagcag tgtatatgga ttgtattgga aatgcagtac 4920 atacatattt taaagtctaa aagattgttg ttgcaaagtg cataccataa tgttaacaaa 4980 atcacagaaa actaaattga aaatcagagg taaaaatagc aactcaaaat cacactggtg 5040 gccacaatga caggtgccct tctggggtgc gttgtttcca gccacccgtt gtgtgccaac 5100 cagcctttgc agtgttgctg gaaagccagc agacatctca ggagaatact gaattagtcc 5160 ttatactaat gaggcattaa ctctagttta tcaataagct ttattaacac ttaacagttc 5220 agcttagtac ctagtcaccg tgtggctctt acgtgtaaaa atgaaaatgt gtaggattgt 5280 gcatcacgtg gtttcatcaa gttgaatgac agaaatgcca ttttatataa taatgatggt 5340 ttcccatagt tcaatttgat aagaatttaa atcagtttgg ggcctatcag gtagatcttt 5400 ccaagtacag ttagttctgc tgtaatccca cacatgcatt accaacagtc actgcactct 5460 gcagaattgg ttaaaataaa taaataaata aataaataaa taacccagag agattatggg 5520 gaaaatggag ttagagggac aacactaaaa aattttgcca gtgacatgtt aaaaacagga 5580 Página 117

P201430887 ES 2 553 786 A1 09-06-2014 acctaataaa acagtagcat aattttatat gttaaatcag taagaaatgc ataaatacta 5640   tagtaagcat ggcactttac cttgaaaaat atttacattc tatagttggg agtaggtgcc 5700 tgtgctccca aggtacacct gcccctctgt gtgtaagagg aagaaaatga ggtagaacag 5760 aggagaaaaa ggcaagcaag gcagagggga atacagagca ttggagagca cggtgggcct 5820 ggggagggtg cagtgcagtg gggttggagc ctttgggtca tagcaggtga ggggcacaat 5880 gtgtggccca ggtatgaatg gactgagctg gtaggtgtct gagttgtgtt tcatgggatc 5940 ctggtggctc cagtcagtgg gtgcagtttt ctgcattcac ctggtatttc ttgcctatga 6000 aatcccacat aagcaaatgg gaatttgcct ttggtcaaat tgttccttga tgtattgaca 6060 atgttggaac aaatttttat tttcaagcaa gtgttccaga gtggagctga ttatactgta 6120 tgcccttgtc cttcttggag aatcaatgat ggggaggagg acacagcact gaggagaatt 6180 ccatcattta acaaacatgt cctaagtgcc ttctgtgtgc cagacactgc actgagagtt 6240 ggggttatag tacacacaaa gaaaagtttc tgcacaaatg ggggtttatg ttctagtggt 6300 agaggaagaa aaacaagaca catagagaaa taataaagca ggtggaggct gggcacagtg 6360 actcacctct gtaattccag agctttggga ggctgaggca ggaggatcgt ttgaggccag 6420 gataacactg gcctgggcaa catagtaaga ccccgtctct acagtaatgt taaaaaattg 6480 gcctagtgta gtggcttgtg cctgtggtcc caactacttg ggaggctgag gcagtagaat 6540 tacttgagcc caggagtttg aggctacagt gagctatgat tgtgcaactg cactccagcc 6600 tgggtgacaa agtgagaccc tgtctcaaaa aaaaaaaaaa aatactacta ctactgataa 6660 agcaagtgga agtggaagtt gggaacgatg gagtggctaa agaaaacctc agagatgata 6720 tttgaacaga gttggtacag tcacatgact cttgatgagg ataggttctg agaaatgcat 6780 cattaggtca tttcattgtt gtgtgaacat cctaaagtgt gcttacatac acccagatgg 6840 agcagctcag tacacacctg ggctagatgg tacagtctac cgtcctaggc tacaaacctg 6900 tgtggcatgt tactgtactg aatactgtag gcacagtgtt gtaacacaat ggtgtgtgtc 6960 taaacattga aaaggtacag taaaaataca gtataaaaca taaaaaatgg tacatctgaa 7020 tagggcactt agtgtagctg gagctggcac aactggaagt tgttctgggt gaataactga 7080 gtagtgagta aatgtgaagg cctaatacgt cattgtacac tactgtaaac tataaacaca 7140 ttacacttgg gctacagtaa atttataaaa acatttttct tcaataataa attaacctta 7200 gcttactgta actgttttac ttgataaact tttaaaatcc tttataataa cacttagctt 7260 aaaacacaaa cttattttgc tttacaaaaa atctttcttc attttatttt attttaactt 7320 ttatattcag ggttacatgt acaggtttgt tacataggtc aacttgtctc atgggggttt 7380 attgtacaga ttatttcatc actgaggtat taagcctagt aattagttat ttttagttat 7440 ttagttatat tagttatttt tcctgatcct ctccctcctc ccaccctcta ccctccaata 7500 ggccagtgtg tgttgttccc ccgtgtccat gtgttctcat aatttagctc ctacttataa 7560 gtgagaacat gctgtatttg gttttctgtt cctgtgttag tttgctatgg ataatggcct 7620 ccagctccat ctatgtcccc gcaaaggact tgatctcatt ctttttttat ggctgtatag 7680 Página 118

P201430887 ES 2 553 786 A1 09-06-2014 tattccatgg tgtatatgta ccacattttc tttatccagt ctatcattga tgggcattta 7740   ggtttattcc atgtctttgc taaaaatact ctctttatac ccctatttga tagctttttt 7800 ctatttttac tttttttttt ttttcttttc agttggagcc ttgctctgtt gctcaggctg 7860 gagtgcagtg gcgtcgtctt ggctcactgc aacctccgcc tcccgggttc aagtgattct 7920 cctgcctcag cctcctgaat agttgagatt acaggcacac gccaccacac cggctaattt 7980 ctgtattttt agtagagaca gggtttcgcc atgttggcca ggctggtctc aaactcctga 8040 tctcaggtga tccacctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccacc 8100 atgcccagcc atctattttt actttttaaa cttttttgtt aaaaactaag acacaaatat 8160 accataagcc tgggcctgta ccaagtcagg atcatcagta tcactgtctt ccaccttaac 8220 atcttgtccc agtggaaggt cttcaggggc aataacagac atgcagctgt catctcatct 8280 cctatgataa cattgccttc aggaatttct cttgaagcac ctgcctaagg ctagtttaca 8340 attaacttaa aaaaatgtag aaggaatata ctctaaaaca atgataaaaa gtaggtttgt 8400 ttacaccaac attaccacaa atgtgattaa tctgttacac tatgatgttt tgacagccat 8460 gacatcacta ggtgatagga atttttcagc tccattataa tcttatggga ccactctcat 8520 atatgtggtt tgtcattgac tgaaatatca ctatgcattg cctgactata tttgatcaga 8580 gatccaaatg ggccatgcag agatttggga aaagaagatt ctagacaaaa ggaatgggaa 8640 aggccgagcc cctgaggcag ggcacatttg ggaagctaag ggtgtggact taggaggagg 8700 agggtggcag ggttagggtg gagaagtaat ttctttcctg ttgaaataac tgctaagtta 8760 aaagaaaagt tgcaagagga attcaaagga atcctgaata ccctacgtcc aggtttgcca 8820 gtttttacca cttgccacat tttctttatc atcctttgta tttacatttt tttgaatcac 8880 ttgagtcagt tgtaggcatt gtgcctcttt atctctaaac atttcagttc gtatttttct 8940 aaaagatatt ctgttatata atcacattaa aatcctcaaa atcaggaaat ttaacattgt 9000 ggataatcct gttaaataac cctctgcagc ctatgtcctc tcctcttgaa tctggattgg 9060 gcttgtgctg ctttgacgga cggaatattg aggaagtggc cttcagaaag tttggcagct 9120 tctacttcct ctcggagccc gtggttgtca tgtaagaagt gcaggatcac cctctgctgg 9180 agagagagac cacacacaaa ggctggagga tgagactgca gagggagacc tcattagtgg 9240 gcaccaaagt gccagacatc caacacccag ctgccacctt aagcacaggc atgtgtcccc 9300 aagagtgagc atctgattca tgagatacag taaaattgtt gctttatgct accaagtttt 9360 ttgctacgca acaagacttc ccctgcttca tacacattgt gccagtcaca agaggatacc 9420 tccctctggg catatagact acaaaaaggc accttgctgg ggcacaggtg gccagggcac 9480 tcacacaggg aggagaggcc ctgcaggatg tccaccccac cggcccctca tcctggtgcg 9540 ctctgtacag cacagggctg cacagcttct gcatccgggg gctggaggtg gttgtggaag 9600 gatgcccaca ggcagctcgc tagtctgcac gtgttctttc taactgctgg gcttttgtgt 9660 tgccctgcct ttgcccagtg tcctatggcc ctagaggcct gggccgtcac tgctaatgtc 9720 gtggcaatgc caggcaatga ccaccccaag gccatgctgg ggagaggtag aacattttga 9780 Página 119

P201430887 ES 2 553 786 A1 09-06-2014 tatttgaaca gcttttgtcc cccatccttt ccttgccctt ccagccagct cttcagtgcc 9840   ctaggcaaca gccactcatt tctcacatcc ccagctccaa acagccttca gtgaagctgg 9900 gtgtgtgtct cattttgttg ctatagtttg ttactggaac ctctctcact ctcatttctt 9960 cagggttgat ttttcaggaa ggagttagca gcccatccta gtttgtcaca taggtggatg 10020 ggcagctatt tcttttcctt caggctatat ccttcagcat acacctctaa tagattttaa 10080 caatctgtag gttgttattc ttgcccctag actgtgaact tactcagggc agggtgggtc 10140 ctgattcgtt tctgtgccct aaccatcagt caactagtat ttcctgatgt aagcgtcatg 10200 aatcagccca gtcatttctc tggtcacctt cagtcaccag agtttgccct gaatagaacc 10260 tcttgatctt tgaacacagt agctgtggtc catcacccag atgaatgacc ccagcaccaa 10320 aactgtccat tgatatactg gaaaattacc attaatggac ttaagcgggc cattaactta 10380 ttttttctgc ataattgagg cgtaaagaat tattcaattg ttcatgattg aatgtcgggt 10440 ctataggtag atcaagatac tgtctaaggt caaacatttg agagctggtc tgtgtttgca 10500 tgtgattgac aggcaaaggc ttaaggaaaa tggagaggag aattgaaggg gaggagggtc 10560 aaggaaacga ggaaagagag tagatagaag tgaacaagcg gaggtggaaa aagctagatg 10620 aaaaatgaag gagcgctaag aagaggagaa aacaaacacc agggcaggag aggagctagg 10680 agagcaggaa gagaggatgg ggggatggag ggcttatgag gttatcttta ctctagttcc 10740 tccatcttac tgtgtttttt atgaccccga cagttttgaa gagtgcaagt ggctcttttg 10800 tggtatagcc ttcaatttgc atctgttgag gatctgatta aattttagtg tgcattttgg 10860 caggaactgc ttagcagtgt taggtcctcg gcgctgtcaa gacaggaagc gcatggcatg 10920 gtctgtccgt ccctgtgtgg gtaggtgtcc gccaggtctc ttctgggaac ctgcctctgt 10980 gggaaagtgg tgacactgta atgtcctgct gctcaccagg cttccaccca cttgtttcag 11040 catctcccga taattcctgc cagagtccat aattattgtg atggctataa aacagtgatt 11100 ttctaaccct gtattgcatc tatgtttatt cactgacatt ctagagcatg caggtgctat 11160 taattaatga tttgatattt attatcagta tgctgtcatt gattttttct ttttagagac 11220 gggctcttgc tatgttgccc aggctggagt gtaatggtac aatcacagct cactgcagcc 11280 ctctctccca gagtggttgg cttggcctcg tttatgctta tttcattcaa ctggttataa 11340 ttaatcactg tcactgtttt ggtgctcaca ttgttccaaa tttggctata gggagtccct 11400 ttaattggat tctatgccct tttgatgagg gccgctattt gcttcatcaa agagtacgtg 11460 aggtcatctc agataagagg aaatgggttt agagggttgt tggaggagat ctgaaatcat 11520 cttgttggct ggtgggagag aatgatattg aggaatgagt agaaggtggt gttgagggcc 11580 cacttggggc tggaatctgt ggccacagta ttattattgc cattgttatt gaactttagc 11640 ctacttttgt aatctaattc taggtatgga gatggtggac atttgggtcc cttttaggga 11700 gggttttgct aagtgggtga aattttaaaa actctgaaga ttaggatgct aggaaagaat 11760 aggtggagaa tccctgtgct tcttcccttt taggaatgga ttttgaatac tgcaaccaaa 11820 ctcttgaact tgtaatgaag ttaacactta acttttcttt tgatgacatt atgaaaagga 11880 Página 120

P201430887 ES 2 553 786 A1 09-06-2014 tatgattaat tttttgtatt tgaaatgtga cacttgctat ttatgttaca gaaagaggcc 11940   tctgatcctt tcagcctaaa tgaattacta gatgaattat caaggaaaca gaaagaagaa 12000 ttatggcaaa ggctgaagaa tttattgaca gatgtgttgt tagaaagccc agtggatggg 12060 tggcaggtag tggaagccca gggtgaagac aatatggaaa ccgaacatgg ctcaaaaatg 12120 gtagtatttg tttttcaaaa ataagaaacg tttttctctt ttttttgtca aaaaataact 12180 tcactgtgta tcattgaatt ttacattaag acagattttg aagttagaag tcaagaattt 12240 tagaagttta gtctgttgta gttttattca cttttcaacc ctactgttat taatctaata 12300 ctaaatattg ctgttctttt aggatgattt acttttattc aactttaatt ctttttagaa 12360 taagctagaa ttgtggcttg atttttagaa aatttgtaac tgaaatttct gctaaaaact 12420 gattttaagt tgatgatttt aattcactca tgctttgatt tttcatttat agagaaaaag 12480 catagaaata atttatgcaa ttacatctgt gattcttgct tctgtgtctg taataaatga 12540 aagtgagaac tacgaagccc tactggaatg tgttattata ttaaatggtg agttgatttt 12600 gttataaatg gcatatttag aagtgggtgt tgaaatactt gtttttgttt ctgtttttat 12660 ttattcattc atttatttat tttttttgag acggagtttc gctcttgttg cctaggcagg 12720 agtgcaatgg cgcgatctca gctcaccgca acctccgcct cccgggttca agcgattctc 12780 ttgcctcagc ctccctagta gctgggatta caggcattca ccaccacgcc cgcctaattt 12840 tgtattttta gtagagacag ggtttctcca tgttggtcag gctagtctca aactcctgac 12900 ctcaggtgat ccacccgtct cagcctccca cgtggctggc ctgaaatgat actttgtaaa 12960 aggaaactag ttgttttcat gagcattgtt gaatttagta gcagaagttg tataaaggta 13020 tagctttgca gtcaagttct ttttcttcag ctagaatagg agcatactta cataagagtt 13080 gtcctgaata cttatttatt ttatatttat catttttttt tagagacaga atctcgccct 13140 gttgcctatg ctgaagtgca gtgacatgaa cccagctcac tgtagccctg acctcctggc 13200 ctctagctat cctctcacct cagcctcctt agtagctggg accatggccc atgctttttg 13260 ttttgttttg ttttgttttg ttttttggta gagacaggat ctaactgtgt tgcccaggct 13320 ggtctcaaac tcctgtgctc aagtgatcct cccaccttgc cctggcaaag tgctgggatt 13380 acaggcatga gccattgtgt ctggcctaat tagtttaatt taagctccat tcagatgtta 13440 tagatggtga gatgggcagt actcagcaac taactgctat ttacaggttt ttcagggaag 13500 tctgacttac tggaccaatg atcaagaact tgttgagaag aaaatacctg attatgtgat 13560 taccattgct agatagtgtc aacttaacta agaatttgtg acactgaatt ttttcttaaa 13620 gtatgttgtg aacgtgatct gaggagtgat tattgactcc taggggagtt ttactgtatt 13680 gaaatttaaa tgatggtact tttcaagttt taacaaaact gtaaaactag ttattaattt 13740 agtctaagtt aatgaaaata tttgattatg aaatatataa aattttagtt acaaaagatg 13800 taaaaatatc ttaatgattt ttaagaaaac ttttcacata ccctcatcct tcactgtgcg 13860 agtgtaatta gtttgttgtg acaaagtatc tcatcaagct tcttattctt agcatcactt 13920 ggatttatgt atgttttata gtacattgtt ttattctgaa ttcttgagtt gaaatacagt 13980 Página 121

P201430887 ES 2 553 786 A1 09-06-2014 gtcttattaa aaagtcaccc caatcataat gaaaatagct tccaaatgct ttgtgaattt 14040   tactatcagt ttatttgtat ggtctgcaaa taactagtga aatgattagt gctaacactg 14100 tagttgctat caacttccca gttaattcag gaatgttata ttagtgtaat gacattcaga 14160 tacctacaga ttataattat gagcattagt atcattaatc taattattga gcttttctgt 14220 taataaaagc actgcagttt ttgtattcat tatggtaatt gctttgactg tttttcacct 14280 ctgagccaaa atttgaggct ggcacattga gggatagtag tggattattg attggtcagt 14340 agacctgtct tggctctggt gttaacagag ataccattgg tgttgttaca ctgaggtttg 14400 gttagcctca gcatctgcct ttctaaaatt ggtgatacga tttctctgag acttccagtt 14460 ccaaaaatct cttttctatt atgtctgttg agggtctttt tataacaatc gtcaaacagt 14520 tttttaatta acattatttg cattttataa ctaatgtata taaatctttg gcaagttaaa 14580 cataactaat attatttgct tagcaaagct ttaaataata tataaagtca tgatactcta 14640 aactgttgac tctgaagtaa taagaatttg ccttactaat tggaaaatta ctgtgctgta 14700 ttttaggtat tttatatgca ttacctgagt ctgaacgaaa actacagagt tctattcagg 14760 atttgtgtgt tacctggtgg gagaaaggcc tgcctgccaa ggaagacaca ggaaagacag 14820 cctttgtcat gttactaagg aggagtctgg agactaagac agtatgctca ctttttattt 14880 ttttaaagac agggtctctc tctattgccc agatggagtg cagtggcatg atcatagctc 14940 actgcagcct caaactcctg ggctcgagca atcctcctgc ctcagcctct caagtagctg 15000 agacttcagg agtgcaccac ctagctagga ctttattttt aaacgtcttc ctaacattct 15060 aaacctgcgc tattcaacgt agtagccact tgccacagaa agctgtttaa atttaaagtt 15120 aaaaataatg aaaaattcag ttcctcagtt gcattagtca cattttagta gctctacagt 15180 gaaatgtggc taatgtctac tgcactagac agttcagatg tataaaatct tcatcatcga 15240 ggaagttctt aaacttgctg gatttttaat tattttcctt atgttttaaa aaaatgttct 15300 gtagagctat agggggcatt tgcaaatttt aaaatctgtt tttatttgtc gttatttttt 15360 aatctttgat gaatcaacta gaattaccat tatttatgat ataaaatata cttgatttga 15420 aatatgactt tactgttcat tgaaaaaggt atcacatttt ttgtgtcatt cctagggtgc 15480 agacgtatgt cggctttggc gtatccatca agctttatat tgctttgatt atgatttgga 15540 ggaaagtgga gaaattaaag atatgttact tgagtgcttc ataaatatta attatatcaa 15600 gaaagaagag gtaaataggt atttgttttt tgatctgttt gtgagctgct tcttaataga 15660 tgtttctcct gtgttcacat ggttcctgtc tgcaccatgc tcggtgttgc ttagctacca 15720 ggagctattt actgcacatg atttttactg catggcagta ctagagaaga cattttacaa 15780 gtccttgctt atttcatcat taaattggat ggtaacaggt ggctgtgtgt tacctagggg 15840 aaccgtaatt acattttaaa ttaagaatga ttaaaaataa ggttgagaaa gcacttctct 15900 atgaatgaga tctggccttc tgccctaatt ccattttaat tgccatgtac tcaaaactgt 15960 catcccataa tatcctccct ttcttttttc tacccatcct gtaaatccag agaggcttct 16020 ggcctgttgc tgcactgccc gtcctggggt caactcccat atgaggctac tgagcacctg 16080 Página 122

P201430887 ES 2 553 786 A1 09-06-2014 aaatgggacc caactgaact gagattagcc ataagtataa aatacacatg gatttgaaga 16140   tttagtggga aagaaatgaa cataaaatag ctcattaata atttttgttc tatacttaat 16200 ataatagaca atatttttat tgtctgttat attaaatatt gctttacata aaatatatta 16260 ttaaaattaa tcttctttac ttttgttaac atgactacta aagaattgag aattacagag 16320 aggctcgcat agttcttctg tgttaggggc cttctgcagt tgtttactga gcgtcgacta 16380 catgctcagg cagtgccagg ggagactaga acaagctttt gcatttggat gctcatggct 16440 cagcaggcac atctctgagg cagaaggagg aagtcatccc tcctccctga aggaggtgga 16500 gaagggcttc agaggaagag gaggaccagc tctgaggtac agaataagtt tcctccaggt 16560 gtcacagctg ctcagcggca gagacagaac tggaccccgg cgagccatct gcagtctgct 16620 agacaaaggg ccatgtgatt aggactgaga cctttggctc ccagggtctt tgttcacttt 16680 ataggtggtg cccttggtca ggcctttcag cctcagagtt ttgttctgta aaataggagc 16740 aacagttact gtttcacagg attgttgtta ggaacagatg aggtaatatg tatcaaaccg 16800 cagcccaggc gctggtggat aagaacccct ggggagggct gccctttgcc atccttgctg 16860 tgtcagcacc atcgttatta caaagatgtt ggacacagcc tgtgccccac acatgtctcc 16920 aggattgttc tgaaatggga gagtgaagaa attaatgatg gattcaaaca ataaactatt 16980 ttatgttgac ttatacataa ggagttgatg aatcgtactt gttaacttat atatgtgtgc 17040 agatatataa cagacataaa tgtatgtatg tgttataacc tctacccttt ttaaaaaatt 17100 gatgtctcct ttgaatttaa gatatctaaa tgtagtttcc taatcaatca ttaatttggt 17160 caggtcagtt tccagtcatt ctgggtaaac cataaacatc ttgtactgta ctaacagatt 17220 acttccagtg aatattactg tttttttttt taacttgcct gttgtgagca tggttaccct 17280 gcatttgaat caaaatgtat tgcatttctg taggattcca gttctgtgca gtggtgtgct 17340 ggtaagagat gaaggtgcta ttcactgaga gagttctaga tagatgcatc ttatgcactc 17400 tatagagtat gaagattgta ttcattcttc ttaggttcag atacataatc tagtagcatg 17460 catataaatt atcatcacat gatgtattta tgacttgaag actgtgtatt tggaaattct 17520 agcttgacaa acacttagcc ttttaactat atgagtcctc agttttctca tctataaatg 17580 agaaggtgaa atgaactggg atattcaact ccattcccac ccacctatgc tagatttaaa 17640 gctttctttc atttgagact atggaaccat ccatgacaga gccagaatga gatgtttatg 17700 gacccatggt tactgtctgt ggtctccatc tctgcacctg tggcccttga ggacagaggc 17760 gctcagtgta gcggctgctc ggccctgggg gaggtggctt gtgtggctcc tggctgtgca 17820 ggccccgcag acagctcaac tcgtgcatgt gctctcagtg ataattacat gtgcctcgtt 17880 tttagcaata gcaatgttta gcttactaga cgttcaaata attgtttgtt atttggcact 17940 ttttatttgg ttgcaatgta aacattctat ccttttttat ttctagggaa gaagatttct 18000 tagttgtctc ttcaactgga atatcaactt catcaaaatg atccacggga ccattaaaaa 18060 ccagttacag ggattacaaa agtaagtgtt aaaagtactg aagattttgt gctgtcttaa 18120 tctggttttg aaagattcca tttggtctga cttcttaagt tatagtaatg gattagaagc 18180 Página 123

P201430887 ES 2 553 786 A1 09-06-2014 tttagaaata cgttatttat tatgtaccat tggatcactg ggtagctttt tccttttata 18240   ggaaatcatt cttttccagt attgaccact gaaattaagg ttttaatttg tggtagttct 18300 ttaaatagtt aaaatagttt ccagttgaac cttagcctcg ctcgtaataa agccatgtcc 18360 atggtacttt gaatgcaatg tgtgcttttt ggttgaacgt ggcctggcca gggtggcttc 18420 tcggaagagc ctgtggaatc tgcaggagca gcagggaacg ttgcagtcat gactctgcca 18480 ctccctgcgt gatggagatg tcaagtgtgt gcttgtcgtt tgccaggcac aaggcagagt 18540 acttcatttg ctccagcact gagtacttag tctccatttt aaaatttaat cctcacaact 18600 ctcttttgag ataggctttg ctttctaaat ttcccagtgt caggcaactg tataagtacc 18660 aagttgggat ctgattctgg atctctgatt gcaaagctcc tgttgtatac tagattgctt 18720 tttcatattt cctcatcttc agaatatttg agttgaacta atagatttct aagcttatga 18780 ttcttaagtt gatactggta ttttagggct tcttgtacct caggaattgg tagcgtgaaa 18840 agtccaacgt gactccaagt cgacaattta tttatattta aatatttttg actttagaat 18900 tttgttctgg acttatgcac tcatagtttc acagaaaata gtaaagtttt gggtaagcct 18960 tgactgagaa ggatgaaata gttcgtcact tcagtttcct ttcccaaaac cttctccgtt 19020 ttctactttt tgctacaggt agataaccta tttctataga tgatttgcaa agcactagtt 19080 taaactgagt ttcttcttca ctatggttgg agagtagctg aaatgataca tgttgaaaga 19140 ataattctta aaatttgcat taaaactatt ttgatctttt tatataggtc tttgatggta 19200 tacattgcag aaatttattt cagagcttgg aaaaaggctt cagggaaaat actggaggta 19260 ttttcatttt tttaaatgtt aacacttatt tttattatat tttagttact aaataagtag 19320 tcaaagaagg gttatttaag atccatgttt atgcactctg tcaaaataaa gccaaataat 19380 gaaaatctat ttgatgggca atccagtcac ttgctaagat gtgtggtttg tgggaggtag 19440 gactgtgctc tttcagctgg gagggagctc tgaccctgat ctttccagcc atgtgctcac 19500 tgggcatttg gaacgtggcc agtctgaatc aagatgtgtt gtaagtgtaa gaaacatacc 19560 agatttcaaa gacttcatat ggaaatgaga atataaaata tctcagtact ttttaaaaat 19620 gttgagtgaa tgttgaaatg ttagtggttt ggatgtatta ggcgaaatgt ggtagttggc 19680 cctttgtggg tttcgcatcc atggattcaa tcaaccaagg atcgaaaata tttgggaaaa 19740 aaatgcattg tacttaacat gtacagactt ttttttcctt gtcatcagtc cctacacata 19800 tagtgtcaca actatttcca taacattgac actgtattaa gtattataag taatctagag 19860 atgatttaaa gtgtgcagga gtgcataggt tatatgcaga tactactcca ctttatatga 19920 ggaatttgag catccgcaga ttctggtctc tgagggaggt cctagaactg atcccccatg 19980 gataccaagg gatgactgtg taatattgaa gtaattttac ctgtttcttt tgtctgtttt 20040 taatgcagcc actagaaaat ttaaaattgc atctgtggct tgcattcagt ttctattgga 20100 tagtgccgtt cagggacttc aagtcacctc ttttagttac attatttttg agaatttgaa 20160 gatattttct ttgattatgg gtaactctgg tgaatacata gtatttatgt tatgaagata 20220 gggctatgta atccacaatc ccaactcaac atccagatac ccttttggac aaaaaagtgt 20280 Página 124

P201430887 ES 2 553 786 A1 09-06-2014 gtttgttttc ccttatattt ttcttatacc aggttctcaa tcattttatt tttctctgag 20340   aataaaattt ttactctagg tcagaaagga gcctctcaca accctgtgtt ctatcctgac 20400 ttttcattcc tctttggaga gcaggccctg cactgatggg cagagggagg aacctgcaga 20460 gtggacagag gctgccccat gtctgggttt acttccatcc tctctgctcc tctgcacaac 20520 ttacacttga tttgtattgc caaggtttat cactgacttc tagaaaataa aaaataggct 20580 gggcgtggta gctcacgcct gtaatcccag cactttggga ggccgaggag ggtggatcac 20640 ctgaggtcag gagtttgaga ccagcctggc caacatggcg agaccctgtc tctacagaaa 20700 aataaacaaa ataaaaacta tttgactaga tgtatacaaa attggtatca acaatgtgta 20760 tttctcagtc tcactccatt cctctctgcc ctccctctct ttaagttttt caggcaaatt 20820 ccagacctga catttcattt ctacatacta ctttattcat ctctcaaaaa tgtgcttatg 20880 gaatgccatt gtaagaccta aaaatgtgac agtaaatcct tggtattttt aaaaataatc 20940 aagccacatt aaaatttttc cagtgatctc aaatgtctcc ttagagtttt tttgaattag 21000 gactcaacaa gttgcccaca tggcatttgc ttgttatacc attaaaatcg cttattctag 21060 agcattcctc cctcctttcc ttttcttaaa atctatgcca ttggcatgtg aggaaactgg 21120 accagttgtc ctgtagaatg ttggcatact gatagttagc tctaaaggtt tggattcaac 21180 ttttatggta caaataactt cccaggtagt gctgtgtatc tcatctttca ttgcaagtca 21240 gacaatgtgt ggttgtccca cattaagtga tgctaagtga cttcaggtga aggaaatatt 21300 ttcaaatata atggggaaga ggaacttgag catctgcaga ctctggtttg tattagtatt 21360 aaccctagga gcgtttcctt aggtccttcc tcaaagccac agaaatcctg ctcatgtgtg 21420 agggtgggca cagagtacag gtacagacat agggtccact ggggtttttt gctactctta 21480 gaggctaggc cttttcccag ttgctgcact ctgagtacca ttagtgcatg gggctgatga 21540 agggcttccc acacaccttc cttgctcagc ccttgtcaac agtggccctg aaatatctta 21600 tttacagttt ccgccgtaga ggtagttctg tttttgttct gtggaggctg ttggaacaaa 21660 tccagtcttc tgaaggttgt ccaggtcagt gatgagtcag aagagggggc tccacactca 21720 ccatgcactc agtctctgaa atttgtctga tttgaactag ccttgagtgg taggtggaat 21780 cttacattgc catttggcac agatttgata tttcatcaaa taaaagagaa gcaaagcatt 21840 ctccttgcta taagaaaacc aaagggattc taagaagcat ggacttaaaa taagaaagct 21900 tggacaaaag ggtccaggtt tttttctcat gaaatataag atggacaggt cagactcttt 21960 gtactcaaat gccgcactgc ttgtcaggtc gtcagtagga cacacacaca ccaagtgctt 22020 tgcattgcat ttgttatttc aggcgattga aaatgattgc atccaggact tcatgttcca 22080 cgggatacac cttccgagga ggtctccagt gcattccaaa gtgcgggagg taagattgtg 22140 aacagattgt ttttgaaata atgtttcctc tgttttgttt ttagataatt gttttggtta 22200 aattttaaaa ttaagctttc acagacatca gttaggggga tttctcagaa ccttgatatt 22260 tgatgtctgg cagttttatt cctgccacca aagttttaat gaggaaagca aaggtgtatt 22320 gttgagatgg ttagtattgt atttgaatga ccttaaattc aattctctgt cttgagattt 22380 Página 125

P201430887 ES 2 553 786 A1 09-06-2014 tccagaatta ttggtttcta atggccacta tcattttttt caaagatcct agagggtatt 22440   tgaaattatt tttattattt tacttattaa attccaattt tgctcttctg caaaccaaat 22500 gaataaatgt tttgattgtt tcttttgata ttttgttctg taaaggtaat ctcagaattt 22560 agattaatct cagaatttag atatgaactt tacctttata ttaataattg taaatggact 22620 gactagataa gattctatca tcagtgccat tactacactg ataggtgttt gatggatctt 22680 aaggatcctg gcaggaggaa tgggaaaatc tggtctgctg tgtttattta aattaagcag 22740 ctgctgttga tcagtgttct aacccatggg atgccttgtt tgcttgctgt tagttttggc 22800 aaccatatgt caagaaacca agtgaataaa gactactcat ttctttgttt tgttgtagag 22860 tgaaactact gctatttata gaatgtaaat atactaatta tattaatttt gagtggataa 22920 gaaaatgttt ctttgcatta ttgatgattt aatttcagtt acacaaggat aaagaaccca 22980 gagatttatc tagactactg agttttccag aggatttaaa aatcgtgatt gcatatattt 23040 aggataaata tattcaatga actccctgtc ctacccaccc cccaccccca tcccagtgtg 23100 gctttattta gttgtagtca gtttgggtta tttatttcac atagatgagt tggtgtttca 23160 aattttattt agtagaattg cattaaacta tgtatttatg taaactatgt ttatgtaaac 23220 tatatgtgta gtttatatgt aaactatgta tgttttcata tgttattttt gctgtggtag 23280 tctgagtaat taagatatta taagtataga tatcactatt tggtaaattt atggaaaaat 23340 gcacaaaaag aatttaaagg gagaatatta gatttcactc aagtgaaacg tgttactcaa 23400 ctccaagtaa ttgtttttgt cacaacttat aacacattat agtttcttcc tcaaattgtt 23460 tttatttgat aactattaaa tttatctgat aagtcatttt attgatattg aaagaggttt 23520 caggcagtgc ttcagacatc atttgaaatt aaaaatctca acattgttga tgaaaatgtt 23580 ctagaattag acagtaacaa tggtagcata gctctaaata tactgaaagc cactgaattg 23640 tatactttaa aacagtagat tttgtggcat gtgaattaag tcttaagctg tttagaaaat 23700 ttttctatga agcaagtgta ctgttgatat caaagtttga tagtattgta cacaaaaagc 23760 aaactataga ctaatgtcac ttatcaccat caatacaaac tacaaaataa taatcagaaa 23820 aaaataatcc ccatactgca gctcttctag ggttaagttg atacaagctc acttaaagtg 23880 taggctgttc ttttacagcc tgtttaatct ttcaaaattt tcatgtttca ctaataaagt 23940 ttagccccaa aaggtgtgaa tagagaagta aggcaaaatt aattgttgtt agggacatga 24000 ggctacaaag aattttggga agattctgac tggaaaagaa gtgagtagga aaagaagaat 24060 gaaagctaca agaatgatca ttttctgatt ttttcataag ttttgggagg aacttgatac 24120 ctaaattaat ctcatacagt gaggggtcac taagtgtgac acctccttgt tacaaagtta 24180 tgaaacagtt accacatgtt ggtaataaag aggttagtta atgttttgga acaagcgtga 24240 gctcttagaa ccattcagga atctcccctt ttccatttta tcctgaaggt cagaggttta 24300 aacgagtctt tttttgaggt tatgtggctg ttggcagaat agcagaaact agaacccaaa 24360 ccattttata gcccaaggcc attaatcttt ttatttcagc cgtagattct ttcttgtgat 24420 tgactgcatt tactactgtc ctatatccat tgaagttact cctgctgaag aattgtcatg 24480 Página 126

P201430887 ES 2 553 786 A1 09-06-2014 acatgtggat gccagccaga gcctacttgt ggtggagaga acaattctcc ctgttgctct 24540   ttccaaatgc cattttattt tatttattta tttttttgtt aatgccttcc ttttcctttt 24600 tttggtcctt aggttctgag ttactttcac catcaaaaga aagttcggca gggagtggaa 24660 gagatgcttt atagattata taagcccatc ctttggagag gattaaaggt atacatttca 24720 aatagtttat ccgtgtttgg aatgtactac ttgtgctttt gaatttagca aactctaagt 24780 ccaaattaca ataaaatagt aaagataagg ctgaagactg aatgctttct gaaatttttg 24840 aacaaatgtt tttttctttt attaaaagca tttcttggtt tcatttaact ggaaatctgg 24900 attggtttag tgctaactac acagttattt ttaagtaacc atgtttaggg aaggagatta 24960 gaggcatgcc gtaaagcaaa ccagctgagg ctgtgggtgg tttgccgcgc tggcctgggc 25020 tgtccagggc tgtccagatc cttgagatct aacaaacaca caataacttt cagtgcagac 25080 aacctggtat ctttagtgag gatgtggggt gaccacttct tagtgacatg aagtgggctt 25140 tgaagtgagg aagctttatc ttttcatagt atctgttgac attgaactga gcaatgtttg 25200 gtcaatttaa acgttataat tgtctgtaat ttgaaaataa atctgtatca agataattaa 25260 agtgttactt tgggaacact gtacttaagc cttcgtatgt taactctttg ggattctgag 25320 atactcttct tttattatta taggccagaa actctgaagt tcgatcaaat gctgcattgt 25380 tgtttgttga agcatttcct attagggatc caaaccttca tgctattgaa atggatagtg 25440 aaatccagaa acagtttgaa gagctctatg tacgtacttc aggtggtcaa gcttcttaca 25500 gatatcagct ttgtccaggc tgtggcatgt actgcttgtg tgtgtcccca cctcccctgt 25560 aaccgccaga gctctgctcc cacatggcat ggtttctaaa cctggactgt tcttcagaga 25620 gatgccactt ctccctgggg ccttctataa cagcgtggac ctgtggtgtc tttttctact 25680 tttgggacat ttaattattt attactatgt gtggttttaa acattttatg catatgcctg 25740 ttgtttcccc aatggagagg tggtgtcata tggtgggtaa agcacatgct ctggtgtcag 25800 ccccctgctc tctggggtca gagtccacca ctctcactta ataggtatgt ggctttgggc 25860 aagtcactta acttctctgt gtctttctct gtaagtgtga ttgcgatatt gcctatccta 25920 aaggtgttgg gtagcataat gagcaaacac tggttatatt tcagggcaag cctacaaata 25980 atgcctgtgg caggtgattt ttcagatgag gtgctaggat gttaagatgc ggcatttatt 26040 tccaaggagt attgtggatt cttttcatct acttagtctg tatttcctaa cacagcttac 26100 ttaagcagtg catactatct actgtcctaa gtagtaaagt tttaggaaac aatgacaaca 26160 aagtgctgtt gtaatgctgt tgcctgtggt gcttctgaag tgctcccttt tttctttttc 26220 ttttctaact tatggaaaac ctgacatgca gaaagttaaa gtaatagtat aataggcctg 26280 cacagtggct tacgcctgta atcccagcgc tgtgggaggg caaggtagga ggactatttg 26340 aggccaggaa tttgagacca gtctgggcaa catagtgaga cctcgtctct acaaaaagtt 26400 aaaaacaaca acaacaacaa acaaaaaaac agcccggtgt ggtggcacac gcctgtggtc 26460 ccagctactt gggaggcttc agcccaggag gtcaagtcta cagtgagcca tgatcacaca 26520 actgcacccc agcctgggtg acagagtgag accctgtctc aaaaaataaa aagaaaaaaa 26580 Página 127

P201430887 ES 2 553 786 A1 09-06-2014 agtgtaataa atatctgtat acttcttcaa gcacacacac acatccctaa atgaagtcat 26640   tagtattttg ctgtgtacat tatgtatatt tatctacaat tccttttttt ttttttaaag 26700 attccttatt tttaaatttt attttatttt attttatttt agagacagag tcgtgctctg 26760 tctcccagcc tggagtccag tggcgtgatc atcactcact gcagcctcaa atgggaggat 26820 cgcttgaacc caggaggtca aggctacagt gaaccatgat tatactactg cactccagcc 26880 tgggcgatag agcgagaccc tgactcttat tttaaaaaaa gaaaaaaatt ttgtggacaa 26940 caaaatttta atctcatgta attttcacat gccataaaat gttaatttgt tcattttttc 27000 caaccattaa gaaatatgaa ccattcttag cactgtgggc tgtgtaggag caggtaccag 27060 ctgggtctgg cctgcggcat tgttcaccaa agctggctga gagctcctgt ccctggtgct 27120 gcacctcttg aggctttaac tcaaccttta gatggaaatt aggctctatc atgaggagac 27180 aaaggaggtg atctgataaa taagtaagag cagtggttat ttcctgtatc ctctgtgtac 27240 cttaactgtt ctctcatgct ttttgcttta ttggtatttc ttaaacctga gtaatatgga 27300 gaaccttttt ttttttttta aaataaaaaa gggtctaggt gcagtggttc acgcctgtaa 27360 tcccaacact ttgagaggcc gaggaagaag gattgcttga gcaatcctgg gcaacatggc 27420 gaaaccccat ctataccaat taaaaaaaaa atcagctggg cactgtggtg catgcctata 27480 gtctcagcta ctagggaggc tgaggtggga ggatcacttg aggctggaag gtcaaggctg 27540 cagtgagctg acattgtgcc actatactcc agcctgggtg acagagcaag accctgtttc 27600 aaaaaagaaa aggattcttt gaatgttttt aaatgaaggg atgcgacaga aacagcattg 27660 caagtcatgt gctgtcattt tgagtgcttc tctggtgatg gtgtaattgc aaacaggtct 27720 ggacactgaa tccagagagg atgtggttgt aaggtgattg tctggaatat atttttatta 27780 tttttaaaga ttattattga aagtaattaa tagaaaacaa aatgtataaa aacttctgaa 27840 tcccaaggac aggccttcag attcctaaag ttcttttctg tttttttttt tttttttttt 27900 tttgctttat ttttatcatc tttttttctt cctatttgct ttttcttaaa tgactggtca 27960 tcttttccat tcttatgttt ggataaagga ttgggttggt aaggtagtta gcaggtgttc 28020 ttctctagtt gtgtagagtc atgtctcagg tttgcctaaa tgggcagagt gcaacagcag 28080 gaggacttcc cttagtttct gtggaggaag agcaggcagg caggtgaccc ctcggtaccc 28140 aagtacaaag ggccctttcc ttctgggtgg cattgctctt ccttcttttg cttttctgga 28200 ggcttagagt tattgctggc tctttttttg ttcttctttg tctgttgccc agtatctctt 28260 cctggcagat gacacacgtg gtttagaaac catttgtaag actttatcct ggggagcaca 28320 tccttgcccc tgaactcctg ctggcctgta tgcctcatca ggggttgttt gcagcccttg 28380 ccacaaactc ttctctgtaa cctgggctct gggttcgggg ctgatgtgag ctctctgagg 28440 tcacagcctc ctgtctttag agcaccctta cctaggaatg tctaggttac aaccttttat 28500 gctcttttct ccatgaatct attccttatt ccctctctta cagaaatttc tcagtctttt 28560 tgtttctatt attgctaata gaaattgatc attttggtca aattttgggg aagagatggg 28620 gtaaatgctt aattttaact tgaaatcttt ttttctaatt aaagtagtaa gaattctgtt 28680 Página 128

P201430887 ES 2 553 786 A1 09-06-2014 gtgtttttca acgtttctaa tagaaaatgt catgcataat aaaaaagaga ctggagtaat 28740   aacccctgtg tgcccacaac acagttttac tcattgctga ctaatcccaa tctgatttct 28800 tcttcccctg tcttgaaaca tatttgggac atcatatcat ttcagctcta aatgggtcag 28860 aaggtattga taaaagataa tttttttttt aatcatgcca tgatcacagc taaagataaa 28920 ttaacgatga ttgcttagtg tctttgggta cccattcgtt gctctcattt tctcgttttg 28980 tttgaatgtt tctctaacta aggcccatgt gctatgacta actgacatgt tgcttaagtc 29040 tcctggacca cgagctctct tgccataatc tttttgtgtt ttgttttctt aaaacttgct 29100 gtttttgttg tcattgaaga agccaaatta ttctatgacg tttccagcag tctggatttt 29160 atagaaccca ttcctgtgat gccattagtg tgtccctctg ccctttgtgt ttcctataaa 29220 ttggtagtta aatgagagag ttgatccgat tcatgtattt gggattttgt ttcgtgagat 29280 tatttccctg ttgatgtcga atactcccat cggggtactt attgcctcat tgtctgtttt 29340 tgaattttta gtaccactga cgatcatggc ctggattagt tcattacaag tagaattatt 29400 ttattctggg ctctaaaatg cattacagca ttttagaatt caaaagcgtg gtgtacgtgg 29460 gccatgccta atctgaacac ctgccatggt cagctgagtg tgcaggtctc actgaatgac 29520 agagctggtt ttgaggccct gctgtcaggg gatgtggcac atgaggcacc ccatgtttct 29580 ggcttgatct taaatactct gctttagaag cgatagcaag taatctcagg tctaggaatc 29640 catatgtgtc cagtatttct atgctcaaag tttctctaag ttacgaatcc ctgaagtgct 29700 cacgtgtgaa gcagatgtgg atttcgggaa ataagtcaag gtttttaagc ctttctcccc 29760 tcctacttat agagcctttt agaagatcct tacccgatgg tccgttccac agggatcctt 29820 ggtgtttgta aaataacttc taagtactgg gaaatgatgc ccccgaccat tcttattgac 29880 ctcctgaaga aggtgactgg ggaactggca tttgacacga gctcagctga tgttcgttgt 29940 tctgtcttta aggtaagatt ttttaaatta tgtaagtaat gtttatttgt tgtagaataa 30000 ttagaaaaac aggaaaagaa aaagattaaa ataatacctg taatcctact ccacaaagat 30060 aacatttttg acctgtcata tatccaaagt aaggttttta aaaaccaaat tcaaagtgtt 30120 ttctacaaaa aatgatgact tgaactaata gtagttttta gtgtaagggg ggaaggggtc 30180 ccagtactgt tgaatttatt ctcttttgtc tctttgtgta atgtcttgga gaaatatgct 30240 ttgcatagaa tcttgtacat ataatatatt tggattcact taagtaattt tttagtatct 30300 cccacctatc accaacacca attgtagctc aaaccttgca agaagaactc acattttatt 30360 ttctaagcaa cctgaactgt cttcaggttt atagaaattg taatatgtat gttagatggt 30420 agtggggtgg ccactgatct tttttccccc tgactttggt gagaaaatgt gaaacggcca 30480 ggtgtggaat gaaccagagg gagggggcta cccaggctgc aaaagcaaat gctcttggag 30540 agagggtttg gagaatctgt aaagctctca gagaggccaa ttcagagaat ttcttgaggt 30600 actgtgagat gacctaagaa gaactgatct cactttcctg ctactggaat caactgttta 30660 gaagctctga ctcccctgag cacaaagcag gtgacttcct cttctctcag gtgcaaaaca 30720 gacattttca gagcagctct tgggcctcac ggccatgccc tagtgggagc ttctgtggat 30780 Página 129

P201430887 ES 2 553 786 A1 09-06-2014 cttcctcccc acttctcagg aacctgcttg cttattttct gtattggaaa agttttctgg 30840   gctaggtgca gtggctcaca cctgtaatcc cagcactttg ggaggccaag acaggtggat 30900 tgcttgagtt cacgagctcg agaccagcct gagcggagtg gtgaaaccct gtctctacaa 30960 aaagtacaaa aaaaagtagc tgggcatggt ggtgtgtacc tgtagtccca gctacttgag 31020 aggcagaggt gggaggatgg cttgagcgtg ggaagcagag gttgcagtga gccaagattg 31080 tgccactgca ctccagcttg ggtgatagag ccagaccttg tctcaaaaaa aaaaaaaaaa 31140 tttttttttt tctgtgcata ttcaacctct ccctctcagc agtgtccttc ctataggttt 31200 gtaagcatgt tcgcatctcc atccgaggca gaggctcccc catttctcct cattgcagag 31260 aaagatattc tgaggagcat gtctgtgttt gttgagtgat cagacatttg ggctcatgcc 31320 tgttgctctg cagtaattgt taggagcaac cttcttactc tcaaaagagt cttagtttag 31380 tggtcaccta aatagtctat ctccatttcc tgcaactccc cagtctacta taaagcgtct 31440 tctatgtcca ctactccagt aaagcatttc tagccaaggt gaatttcaca tgaccacttc 31500 tctagacttt tttgacctct gagcagaatt cattcctaca ccattccctt gtccctctgg 31560 atgttgtggt aaaacctcag tccctcttct tcctcctggt ctttggttga atactcttac 31620 tcttcaagtg ctggctgagg agccagggag ccgtgcgcct cttgcactgt gacgggctcc 31680 ccctggctat ccggtttcca gccttgctct gactgtggtt tgcatgcggc tggtcccagt 31740 ttacagacaa gcgtcttctt tgagagctct gctcaggtga ccagcaggta gctctgagat 31800 tcagactatc cacagcatgc agattaggaa gtgctcctgg ggtgcacacc tgtgtaaggg 31860 aagggacatt aagccgtgac acagcctggg aaagcctcgt gcagacccac aggcagctct 31920 ggagccagca gagcccttca gactgggccc atgctgattc actattgcac actggctgcc 31980 cgggaagaag aaggcatttt cttcaggagg ccatccccaa gcatgctgat ggcgagggca 32040 gctcagcagc cccaggacag ctggggtgag tgcttcattt ctgatggggc cttggttgta 32100 cgtcatagca accaccctgt ctccactgct gagttgatga ccatcttttc caaacctgct 32160 gccatccaag agttttattt attttcctct ctcccccttg ctcctctttc tccttgaagt 32220 gatgatgcca tctgctgagt cactcacttg cgtgctgttc ttgcttcttc ctccttcacc 32280 caagtcctgt ctttcccttc ctggtgtctg aggttcacct gctccttcct gttgctgtca 32340 tccaaagtgg ctgcagctcc ctggccggtc ttctcttggt cctgaccttc tgaccaccgt 32400 ctggtgcttt catgcttctg aggaaaccct tgcagggcca ctctgagatg cctcccttgc 32460 ccagatgggt catctgtgag gagggatgag tgggctctgg agtagaggaa gagtcagcag 32520 agaatctaca gaagaaagac cagagaagtt gaaggagaat taggagaaca cagtgttatg 32580 gcaggggcta caggggctgt gggattgggg gaactggcaa ggtaggtggt ggccggtggc 32640 cggtgtccag tgggagggca ggatcaagag gaggctgtgg acacaggtgg agcagatgat 32700 tcaaatcagt ctgcccttga gtgctttgga agaagagctg tatatacttg aaattttttg 32760 aaaaaattat cgtcattaaa atatatgtgg ccaggcatga tggctcacgc ctgtagtccc 32820 agcactttgg gaggccgagg cgggcagatc acgaggtcag gagatcgaga ccatcctggc 32880 Página 130

P201430887 ES 2 553 786 A1 09-06-2014 taacaaggta aaaccccgtc tctactaaaa atacaaaaat tagccaggcg tggtggcggg 32940   cgcctgtagt ctcagctact tggggggctg aggcaggaga atggcatgaa cccgggaggc 33000 agagcttgca gtgaaccaag attgtgcccc tgcactccag cctgggcaac ggagtgagac 33060 tccgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa tatatatata tatatatata 33120 tatatatata tatatacaca cacacacaca tgtgtttgga ataccgtata tacttttaat 33180 aaaaacctgt gaaaatgtcc tttctcctga aactagatgg agaaggcagt agagcttaag 33240 cagtgctgga gtttgggggc ccagactgag ccttggcctg tggaggagtg ccacctgcta 33300 cgtggccact gtagtcagcc gagagtgcgt tcgagtcaca cacgctggct ctgttccctc 33360 caatcctcat gcagtatcga gtcaggaaat gcagagttct tggacttggt gcctttggag 33420 accatgtgac cagtagttat tctgtgtttc tttcaactca aaaattctct aaaatttagc 33480 tgagagagag cattaaagat ttcttttata attgctttaa tcttatttga acaaaacaat 33540 ggatggacca aatagcagtg gttggaccta tactggttca ttaaaagtat gccttttata 33600 tgaaatagtt ctagaaaaag tggtattttc cataggtata tttatttcac tagtagttct 33660 aataaagatg gaaccgaatg ttttctttaa tgaagttttc ctacctgaac ctttcattgg 33720 catgttctga ttttgaattg tttatctttc tctctgttgc agtgtctgcc aatgattttg 33780 gacaacaaac tgagccaccc attgttagag cagctccttc cagctctcag atacagtctc 33840 cacgacaatt cggagaaagt gagggtagct tttgtggaca tgctgttgaa gatcaaagct 33900 gtgagggctg ctaaggtagg atgaataggg cttttttact tatgacatga aatagggaca 33960 tgtgttcatc aaacagaaag aaagtagttt taattccaca ttttaaactg ataactgata 34020 tgatttgacc agttatctct gtcaaaaatg ttattttgtg tttttcatca aaggttctag 34080 aaatattatc aatgtgtttt ctttctgaaa gacattaatg taagcacccc tgccttccat 34140 tgtattttcg tcatgtatga aggttttcag tgagatattt ggtgtaatat ttggatactt 34200 ggcacctggt gagcacttct ggagagtgtc tagtatgagc caccccccac ccccaccccc 34260 ctgccccaca cagagtgaag gagggagaca cctgctttat gaggagagtg tctagtatga 34320 gccacccccc acccccaccc ccctgcccca cacagagtga aggagggaga cacccacttt 34380 atgagagatg tgcgttttga tgttttataa actactgaag tgattgttct ctttcagctc 34440 tagttctctt cagctttttg ccaagaatat tgcttataat gttcttgact tcattattat 34500 ttggtaccat tgtgaacttt ctccacacag tagcttctca gaaatttact ttgagtgctg 34560 ttctgctatg gcacaggatc cagaaacaga ctgataacgc cagagtgtag ggtcagccag 34620 acagatttgt gtattcataa gagaagtggt gccgtgtggc catgaaaaga acaaggagga 34680 actttttgtc gggcttcctt ggaaaggcct ctaagatatg gaagtataaa agcatagtgt 34740 agatgtggtc ctggtgtgct accagctgaa taaaatggag acatatatat aagtaaatat 34800 tgctcagata tgggtaaaat atcctttgaa gagaacgaga atttagtgtc agttgcttag 34860 ggtgatgagg tgagggggag acagggtccc actctgatgc ccaggctaga gtgctggggt 34920 gtgatcttgg ttcactgcaa cctcaagcca tcatccctcc tgagcctccc aagtggctag 34980 Página 131

P201430887 ES 2 553 786 A1 09-06-2014 gaccacagga gtgtgccacc atgtctggct gatttttgta gtttttgtag ggatgaggtt 35040   tccccatgtt gcccaggctg gtctcaaact cctgggctca agcgatctgc ccaccttggc 35100 ctcccaaagt gctgggatta caggtgtgag ccaccgtgcc cagccaatga tggggatctt 35160 gtcactgaat gtagtacata ttacgttgtg tgttttgagt tttgatctgt gaattttttt 35220 atattagaag aaaacaaagg atattttgag tgaccaatgt agtattaaca cccaatgtca 35280 tatgcaattg agttactttg atgcttttgt tgaaaatcat tgaccatgtg tgtggtcctt 35340 ttctggactc tgtcctgttg tgttgatccg tttattctgt gtggatctta cagtaagtct 35400 tgcagtgtgc attctccagc tttgctgttc ttccagaatt ctttggctac ttcaggtctt 35460 ttgcatttca tataaacttt agagtaacag ccgggtgagg tggctaacac ctgtaatccc 35520 agcactttgg gaagctgagg tgggaggatc acttaagctc agaagtgtga gaccagcctg 35580 ggcaacatag tgagacctta tctcttaaaa aaatgtagag taagcatgtc aatttttttt 35640 tttttttttt tttttttttt gagacagagt ctcgctctgt cacccaggct ggggtgcaat 35700 ggcacaatct tgccttactg caacctccgc ctcccagctt caagtgattc tcctgcctca 35760 gcctcctgag tagctgggac tacaggcacg tgccaccatg cccggcgaat tttttttttt 35820 taaattttag tagagatggg gtttcaccat gttggccagg ctggtctcga actcctgacc 35880 tcaggggatc cacctgtttt ggcctcccaa agtgctggga ttatgggcgt gagccactgc 35940 gcccggccaa gcatgtcaat ttcaataaaa atactggctg caattttgat ggcatttttt 36000 aaaacagcct gttaaaactg tagttctgtg cttttacact gttggtggga gtgtaaatta 36060 gttcaaccat tgtggaagac agtgtggcaa ttcttcagag acctagaggc agaaatacca 36120 tttgacccag gaatcccatt actgggtata tacctaaagg aatataaatc attttattat 36180 aaagatatat gtttgcgtat gttcattgaa gcactattca caatagcaaa gacatggaac 36240 caacctaaat gcccttcgat gatagactgg ataaagaaaa tgtggtacat atatactatg 36300 gaatactatg ccgccataaa aaggaacgag atcatgttct ttgcagggaa tggatggagc 36360 tggaagctat tatcctcagc aaacaaacgc aggaacagaa aacaaaatac cgcatgttct 36420 cacttataaa tgagagctaa atgatgagaa cacgtggaca catggtgggg aacaacacat 36480 actggggcct gttggagggt ggagggtagg agaagggaga gcatcaggaa taatggctaa 36540 tggatgctgg gcttgatacc taggtaatgg gatgatctgt gcagcaaacc accatggcac 36600 atgtctacca atttaacaaa cctgcacatc ctgcatttgt acccctgaac ttaaaagttg 36660 gaccaaaaaa cccagaaaac aaagtagact ttaaggcaat tattggagaa aactttttgt 36720 gaatattttt actttttttg ttttaatttt ttattttgaa ttttcaaaca tatataaaag 36780 cagagagact aatatagtga attagataca cccatcaccc agcttcaaca attattgcta 36840 tgtccgatct tgttttatct aaactgtatc caggccacac tgccggacta ttttgaaata 36900 aattccagac atcatattgt tttctttgta tttcagaatg tatctctaaa agataagcac 36960 ttaaaaccac tctaccatta ttttataaaa aaagaataac tcttcagtaa aacaaaacag 37020 aaaacagtaa taggtaagga gggcggaggg acccagtagt gggtaaggag ggcggaggga 37080 Página 132

P201430887 ES 2 553 786 A1 09-06-2014 cccagttgtg ggtaagggag ggcggaggga cccagtagtg ggtaagggag ggcctaggga 37140   cacaaggtag gtaaggaggg cagagggacc cagtagtggg taaggagggc agagggaccc 37200 agtagtgggt aagggggggc ggagggaccc agggtcggta aggaaggcgg agggacccag 37260 tagtgggtaa gagggtggag ggccagaggg taggtaagga gggcggaggg acccagtagt 37320 gggtaaggag ggcggaggga cccagtagtg ggtaaggagg gcggagggac ccagtagtgg 37380 gtaagggagg gcggagggac ccagtagtgg gtaaggaggg cggagggacc cagtagtggg 37440 taaggaaggc ggagggaccc agtagtgggt aagagggtgg agggccagag ggtaggtaag 37500 gagggcggag ggacccagta gtgggtaagg agggcggagg gacccagtag tgggtaagga 37560 gggcggaggg acccagtagt gggtaaggga gggcggaggg acccagtagt gggtaaggag 37620 ggcggaggga cccagtagtg ggtaagggag ggcggaggga cccagtagtg ggtaagggag 37680 ggcggagggc cacagggtag gtaaggaggg cggagggacc cagtagtggg taaggcgggc 37740 ggagggaccc agtagtgggt aaggaaggcg gagggaccca gtagtgggta agagggtgga 37800 gggccacagg gtaggtaagg agggcggagg gacccagtag tgggtaaggg agggcggagg 37860 gacccagtag tgggtaagcg ggtggagggc cacagggtag gtaaggaggg cggagggacc 37920 cagtagtggg taaggcgggc ggagggaccc agtagtgggt aaggcgggcg gagggaccca 37980 gtagtgggta aggagggcgg agggacccag tagtgggtaa ggagggcgga gggacccagt 38040 agtgggtaag ggggggcgga gggatccggt agtggctaag gagcggaggg acacagtagc 38100 ggagggacac agtagcggct aagggtggag gagggacaca gggtctctga gggaggcgga 38160 gggacacagg gtctctggcc caccaggaag tttgggcgcc agagcagagg aagaaggcag 38220 aacgtttgcg tttcagtcct tatctttgca agtgcaaggc agacagccat ttggttgtga 38280 ggtgtctgga aaggtttgtg acgagcatgc aagctaattt cccttgaaag ttaaggttac 38340 agaatgacat gagtataaga ggcagtctgg ctggccagag gacagctgtt ggagctgacg 38400 ggagggcatt gtctatgggc aggaacaacc tggcacatga agccaggctg ccgggcctgg 38460 cgtgcacacc tcagtaatgg gtgtgctggc ccagtggagg gtcttgtaca tgcagctcta 38520 gaaggattga gagttatact ttctctttgt ttcctttgtc agctgtggta ggcctgggct 38580 gctgggctga gcccagtggg ccaggagatg tcaaccctct cccttcaatg cattgtcttc 38640 tttttatttt atttatttat ttttttttga gacagggttt ccctgtgttg cccagggtgg 38700 cgtcaaaatc ctggcctcaa gcgatcctcc tgccttggtc tcctgagttg ctgggactac 38760 aggcgggagc cactgtgccc agccaataag tctacttcta tttcttcagc agtgtgtggc 38820 ccgtgcagct ctgatctgtg catttgtgtg ataatgaaag gcagcgtggc agactagata 38880 aaagtgctat gatcttgtac ttaatcactc taagcctgct tcttaccttt aaagtgggaa 38940 tactaatatc tatgctgggg gtggtttcaa aaatacagta aatagtggct caggcacttg 39000 gttctgtgct tgacatcctc aggcatttcc agacaggttg gttgccaaca gcactgtcac 39060 ctgcaggccc gctggtgcag tgttcagggc ttgatacctc gctgtcagaa gtaaccaccc 39120 gttggggctg gagcctgtgg ccaggaggct ttcgtgtgtt gggacaggca gaaggggctc 39180 Página 133

P201430887 ES 2 553 786 A1 09-06-2014 aggatggagg tggacagttg ttctctggtc agaatatgag tcctagtatt tttctctttc 39240   ttgtcctctt aaaccgtgac agcacagcct ctcaccctta ggtaagaaat ctccagtccc 39300 ttaatttcca aggcttcagt caggtttggc agaagattct tgtccctgtg gctgtaggtg 39360 agagctggga accttggccc tgtccactgt cctgtggctg cttgaagtac tggggttgct 39420 ctgtctttcc aatgctagaa tgtgagtaaa ctgccccgtg tgggatttgg gcttattgtc 39480 cttactacag taactttttc agaaatacca agaagtgcct gagtggaagt atccccgggg 39540 cgcttcagga ggtagtaatg acagtgtcag atgctgcaga ttttgtctga gttgagggcg 39600 ttcatatgtc tatttgaatt tgcagtatga gatcatgacc ttggcaagaa caacttcagt 39660 gagggtggac tgcattgtca atggggttgg gaggtgagat atggaggtgg aggtgggatg 39720 caggcacact taggagcagg tcgactgaca agggggaggg aaggtgggaa ccaggagatg 39780 ggaacctcag gttgagtttt gtgtgtgggt ttttgttcta agagttggaa tgatgtaaag 39840 aagaaagatc caattgaaaa tactagaaag aaggattggt ccttggagca aggttcttga 39900 gaaaaatgca aggtcgaggg tttcgctcac catgcaggtg aggagcccga ggcagggctt 39960 gatgtggtgc cattcaattt tgctttgtca tgttctgcat ttttcttttg tcttggattt 40020 cttgtgcaga agattggtgc ttgctttctg taggtagttc gaatgctttt gagaagaggg 40080 acgctatcac tatgatcagt tctgattttt gcaggttgtc tggaggctgc atgtgagatg 40140 ggtgcgggga gatgagacta ggctgtgggc gtccatgatg atctgggcag gcttgtgtca 40200 gagaaggagt caactgtgga tgggacaggc agccccaggg attcaggagt gatgccccag 40260 cctcttagat aggagatgga gtgtccacgt caaaaacgtt gtatatattt ttactcactt 40320 ttcacattaa tgggccaaaa gttaaggtac tttaagaaat taaaaaatat taattgacaa 40380 tcatagctat cattggagag tttactgtat gttaatcatg gtgttaagta attttaatta 40440 aacctcttag caccctaata cttgggtgcc ttatataaca gtacttttaa aaatatagat 40500 ttattaattc taatttctct acagaaagtc acagattttg gtgtagtcat tcgaagtgaa 40560 tttttttaaa tataaaaatt agttcctttt ttggttgtgc ttgaaatttt tcttaagctg 40620 tttccagggt tacaggcaca attgattatt tccttctgca tatgtgcttt ttgcacagtt 40680 ttggaaaata tgtcccatgg agcacattct ggttcgtctg gaaactgatt ctcgacctgt 40740 gtctcggcgc ctggtgagcc tcatctttaa ttctttcctg cctgtgaatc agccggagga 40800 ggtctggtgc gagcgctgtg tcaccctggt gcagatgaac cacgccgctg ccaggaggtt 40860 ctatcagtac gcccacgaac acaccgcctg caccaacata ggtagggagt gctgttattt 40920 ctcagttctt gttatgtttt cccccaaaag cataatacaa attacagagt tcagtatttg 40980 tcaatttaat aagcttcata ctttaatgca tttctgaatg atttccctta aaatagtact 41040 tttgactaat tgggattata atttcactat cagatagtta attttgtaga agaaacacat 41100 ccattaattc ttgtttatcc taaacatttc agcaaagctg attcacgtta ttcgtcattg 41160 cttaaatgcc tgtatccaga gggcagtgag agagcctcca gaggacgagg aggaagagga 41220 cggaagggag aaggagaatg tgactgtgag tagaacaggg ccaggccggg cagatagtgc 41280 Página 134

P201430887 ES 2 553 786 A1 09-06-2014 ctcagtggca tcactcccat gggccattat gttaggaata ttcctatgtt ttctttgttc 41340   ctttagtatt gttaattaaa caagttattt tggaaggtca taaataacat ttgtgaaaga 41400 attgctatat gtcctttgta gttcattttg gagctcaggt aggacttaat acagaagaaa 41460 aattcttacc agtcacatct tgtcccagat tttctttacc ttaaatgtct ctgtatttca 41520 gttcaatcct ggatgtagca tggctggatt ggattctggg tactcccata tttttgaaag 41580 tataatttat taaagggaca atttcttcag aatccaaagc aaccaattat attagaagaa 41640 aataacgttt aagacttaga caaacttgtt acttataagc attatcttaa gcttctaaac 41700 tcctgtgctt gtggacgtct aaagtaagat tttggggtca ttttgcaatg cccactacat 41760 taagaaacta gactttaaaa ggaaatcaca aaacacagtt tgccctgtgc tgaggcacag 41820 tgttggtgtg ctcccctaac agctggtcct gagccaagtg cttctgggtc tgaccccact 41880 gtgtccttcc tagcaggggc agcagatggc tcacccaggc cctgctcatg ccccatggtg 41940 ctttctcctc catctcccac cacaccgtga tgggccacca gcccagcccc tcagtcagtt 42000 atgctgggtt gaaattgttc agaaggcact taccaaaaac atacaggaaa tagatgtgga 42060 atagagagaa gagttcagtg agagtgagag ccacttccgt cttcacagcc gttgggcagg 42120 ccacctccct gggctcacta caccctcact gccagtgttc agagcttcag agctggttct 42180 gctcttggtc ggtggagttt gagtttcttc tctcagggct tctccctcag tatacgttag 42240 agttgcgtga caggcctcga cagcagggat tgttggtggg tctggctgtg tgtctgtgct 42300 ggtgagtggg catgtccgct tactggcatg cagccacaat gcacttacgt gtggcttgcc 42360 gcgttgacag cgtgggactg ctggctctgg gtagaagagg aatttgttag agtgtgtttg 42420 tagtttacag tgaacaggtg agtactgtgc actatcagca tatgttcagg aaagtgtaag 42480 taggtctatt tattttaaaa caaactaaag aagcccatga tcatagtcat tattccagcc 42540 tctcaggctg tgttctgcct gcctgtaggg tggagttggc caaccagaga ctgtgtcctt 42600 tctgtgacct gataggctgg gttttggcgg ctgagtttca gtagcagtca ccttggagga 42660 aagcagcctt caccattccc ctccccctgc atcgagattt gtggtgaaaa gtgatgtctt 42720 ttaataaaac agaagataca gtgaaagaaa aggcatgttt tttaataggg tgttatgttc 42780 ccagatggag acaatagttg atacgttttc ctttttagag gagttttctt catgtaaact 42840 gtttctttaa aggatgtaga gtcagtttgg aatttatatc gtggtgggca tttaaaaata 42900 aatttacctc cctagaagat tctaaagtgg agagtagaag acgtgaaagt aagacggatg 42960 ttctctacat ttttgcttta gagctctaat tctgagatgc tgttaccttt tagtagttgc 43020 tatgattaga tcctttcaca ataaaattat ttttatctta ggttctggac aaaacactgt 43080 cagtaaacga tgttgcatgc atggcaggtt tactagaaat cattgtgatt ctctggaaaa 43140 gtattgacag aagtatggaa aataataaag aggccaaact ttacacgatt aacaagtttg 43200 cctctgtgct tccagagtat ctgaaagtat ttaaggtaag tcttgaacta tacttgtaag 43260 caaggtatat taaggttacg tttgtttaga atttaacaaa agttctcaaa catgtttacc 43320 tccctggatc tgtgttctca tctgtaaaat gagagggttg gattagtgtt taccttgcag 43380 Página 135

P201430887 ES 2 553 786 A1 09-06-2014 tatagtttct ttctgttgcc cctcttgagg gtggagatct tgtgtctctg tctgcttcca 43440   tatcctcagc acccagagaa acgtcttggg taagcacatg attcttctgc ctccgatggt 43500 cagcgacatt atttcagaat ctaatttgat ttgcaggggt ttaagaaaga gtttcgtgaa 43560 catggaggta cagtagtact caagttctgt gggcagttag gtacccgaag gcacccagta 43620 agcaaatatg tccctgaagt atttgagttg tgtgtgttgt tggggcaaac agttgtgtgt 43680 gtgatttctt ttttaaaaaa atttattttg aattgacaaa agttgtatat actttattgt 43740 gttcaacatg atgttttgaa atatgtacac attgtggaat ggccaaatcg agcctcacat 43800 acttaccatt tctgtggcga gaatgcttaa aatctgctcg cggtgatttt caagaatata 43860 ttgtattgtt attaactgga gtcaccatgt tataggatag atcttttgaa cttactcctc 43920 tgatctaact gcaattttga atcctttagc taacccttcc cacccccacc actcttctct 43980 gtgcgtgatt tctatttgca tgcaggacct tctcattcct tgacttttta cttctgaagg 44040 aagtttatat ttcaaaacta aatttaaaaa taggccaaca gcatgtaaaa atgcaaatat 44100 attcttaact ctgaagaaag tgtggtttaa atatagaaag atcgtaggtc ttatgaacca 44160 catttctctt cctaaatgtt actcttgcct ctttttctac ctacttatgt gactttggac 44220 catgtagctt ttctaaccct ttcaaggccc tgagcttcat tctgcctctg acgtgaaagc 44280 atggcctgtc tgcctctgac gtgaaagcag attgtattag ttgccaaaat tgtattagtc 44340 tgttttcatg ctgctgataa agacatacct gagactgggt aatttatgaa gaaaaagagg 44400 tttaatggac tcacagttcc atatggctgg ggaagcctca cagtcatgac ggaaggcaaa 44460 aggcacgtct tacatggtgg caggcagaga gaaaatgaga gccaagcaca aagggaaacc 44520 ccttagagaa ccatcagatc tcgtgagact tactaccata agaacagtat gggagaaacc 44580 acccctagga ttcagttacc taccaccgtg tccctcccgt aacacgtggg aattatggga 44640 gctacaattc aggaggacat ttgggtgggg acacagccaa accataattt accagtaaat 44700 ggtaaagctc attagctggg catggtggtt cacacctgta atcccagcac ttttcgaggc 44760 caaagcagga ggattgcttc aggctgggag tttgagacta gcctgggcaa catagtgaga 44820 cctcgtttct acaaaattta aaaaattagc tgggcttgat ggcctgtgcc ttttggtccc 44880 agctatgcag gaggctgagg caggattgct tgagcccaga gtttgagact acagtgaact 44940 gtgatcatac tactgcactc actccagccc tggcaacaga gtgagaccct gcctctttta 45000 aaaaaaaaaa aaaaaaaaaa aaaaaaagaa agctgaaata atgacctggg actgagaaac 45060 cagcattatt tcagaatatg aacagaagcc catataggac accaggtagg ttggcggaca 45120 gggcagttgt ggccttgggg tatttgaaac ccttagaggg tcttgggatt cagttaattc 45180 tgagtatgtc tataagaagt ctctccacca ctaaggaaaa ttgcttcctt ctctaagtaa 45240 agagatgatg ggtgagccac acagatggaa ttggccatca ttatcagtat acttgtaaca 45300 ttaacgagat attttctttt tttttttttt tctcgctctg tcgcccaggc tggagtgcag 45360 tggagtgatc ttggctgcaa gcctcgcctc ccgggttcac gccattttcc tgcctcagcc 45420 tcccgagtag ctgggactac aggcgcctgc caccattcgt ggctaatatt tttgtatttt 45480 Página 136

P201430887 ES 2 553 786 A1 09-06-2014 tagtagagac gtggtttcac cgtgttagcc agggtggtct cgatctcctg acctcatgat 45540   ccgcctgcct cggcctccca aagtgctggg attacaggcg tgagccaccg tgcccagcca 45600 ttaacaagac attttcttcc catattgtta gttgggggta aggatgggtc actgtgaatg 45660 caaattaatt cctaatcaaa ttttgatttt ggtttgtttc tgtttcatat gtattttcag 45720 gaaaattatt attattatca ttattttagg attcaccatg tcctcattct cccagccaag 45780 aatatctctt attgagtgtt cttgaggaag ggtggatgta ccccctttta cttattgttt 45840 tagtaataat aatttagctg caatttacta agcactgagg acactctaaa tactgtactg 45900 ggattctgtg tggtgtagtt cactttggtt cttccaacag tcctgtgttc cttttgcaaa 45960 gggagaaact gactctgaga gcttaactcc tctcctctgt gctatgtcag ctgttgggct 46020 acagaatctg attgggtcta gatttggttc agtagcctca aagcttactt ttttttttct 46080 tctttttttt tttttttttg agatggagtc ttgctcttgt cacccaggct ggagtgcagt 46140 ggcacaatct cagctcactg cagcctctgc ctcctgggtt caggcgattc ttctgcccca 46200 gccttccgag tagttgggat tacaggcgtg agccaccatg cctggctaat tttgaatttt 46260 cagtaggaac agggtttcac catgttgatc aggctgctct cgaactccta acctcaggtg 46320 atccagctgc ctcagcctcc caaagtgctg ggattacagg ggtgagccac tgtgtctggc 46380 cttttttttt tttttttttt tttaaatata atgccctgtt gcccaggctg gagtgaatgc 46440 ttactgtagc ctctaactgt tgacctcacg cagtcctctc acctcaggct cacaaagcgt 46500 tgggattaga ggcatgagcc actatgcccc actgcatttt cccttgaact atactgtctt 46560 cctaaagata ttctgatttt gttttataac attttctctg aataatttcc ttcttttgag 46620 atttgtgttc aggataccaa gtgtatagag ttaatttttt ttcatttcat cagtgttgtt 46680 ttttaaagta gattcaattc atgacagcat atgattttgt ttatcctgct tactggcata 46740 ttcccagggt ctagattggt actgggtaca tagcaagtgc ttaataaata tttgcaaagt 46800 agtaaaatgt tatataaaac ttccataaca ctcaccaagt aattttctct gcccctcaaa 46860 catgaggctg gtttaagttt tccttttgaa cgtggaaagg actgccatgg ttcttcttga 46920 gcaactttgg tagtaagtta tcaggaattt acgtagagag actttcagaa tttatagtgc 46980 ttacatatgc tttgttttgt ttttcttttt tcgcttttag gatgatcgct gcaagatccc 47040 tttattcatg ctaatgtcct ttatgccggc ctctgctgtc cccccattca ggtatttgct 47100 ctgttttttg gtacggtaga aaagtaggaa tcctgtccat tgttgtgctg aattattaat 47160 tcatgtcagc agaccataac atttagcttt cagctcactg tggcctcttc cttctgccct 47220 tccctctccc tgtggtaggg aaaatatcag gatgtgattt tctttttttt ttttttttta 47280 ttgatcattc ttgggtgttt ctcacagagg gggatttggc agggtcacag gacaatagtg 47340 gagggaaggt cagcagataa acaagtgaac aaaggtctct ggttttccta ggcagaggac 47400 cctgcggcct tccgcagcgt ttgtgtccct gggtacttga gattagggag tggtgatgac 47460 tcttaacgag catgctgcct tcaagcatct gtttaacaaa gcacatcttg caccgccctt 47520 aatccattta actctgagtg gacacagcac atgtttcaga gagcacaggg ttgggggtaa 47580 Página 137

P201430887 ES 2 553 786 A1 09-06-2014 ggtcacagat caacaggatc ccaaggcaga agaatttttc ttagtacagg acaaaatgaa 47640   aagtctccca tgtctacttc tttctacaga gacacggcaa ccatccaatt tctcaatctt 47700 ttccccacct ttcccgcctc tccattccac aaaaccgcca ttgtcatcat ggcttgttct 47760 caatgagctg ttgagtacac ctcccagacg gggtggtggc caggcagagg ggctcctcac 47820 ttcccagtag gggcggccag gcagaggcac ccctcacctc ccggacgggg cggctggccg 47880 ggtggggggc tgaccccccc acctccctca aggatgtgat tttcaatggg ccctaagtta 47940 gtacgtgatg aaagaagaga ctgcatggaa ctgaaactgt tactccactt taagtctggg 48000 gttactctta gcacctggtg tgggaggttc tggagcacaa ggtcaccgtt ggtcacatgt 48060 ggccctgagc acctgggctt tggctatttg agctgagatg tgctgtgagt acaaaataca 48120 tatggagtca gccttgaggc aaaaagaaga gtgtgaaata ttgattacat gttaaaatga 48180 ttttggatag attagattaa ataagattat gttattgaaa ttagttttac ctgtttctct 48240 ttgtgttttc aaatgtgggt actagaaaat ttttaattac atttgtggct tttgtgtctc 48300 ataatatttt tcattagagc tctacaatgt tggtgattat ctcaataaaa attattttta 48360 ttcatatttg tggaagaaaa aggaatattt tgatgctaaa caaaaattgt tcttcaaaag 48420 tagaaactct tgctctagaa tctgacagat ggcacagaaa cagaaggatg agggctttgt 48480 gtggctgctg tgccctgctt cttcagtgtc cagagctggt ctcaggtctt gtggtgggat 48540 gcagctgagc agcaattgtg ggaaactgta tttattcctg cattggagag catggaagtg 48600 ctaatataat aacaagggct tatgcaccgt cagattttag cttcttggtt ttcctcacct 48660 tttgacaaag ttggggagtc tccgttgaaa tactcagtcc gattttccgt ctgacatttt 48720 cagctgtggt gtgatttcca cgctgagaag ccgggaggag ggcgctgtgg acaagagcta 48780 ctgcactttg ttggattgcc tctgctcctg ggggcaggtg gggcacattc tggagcttgt 48840 tgacaactgg ctgcccacag agcatgccca ggccaaggta ggttgacatc atgtttcctt 48900 aaaattaggt gagtgaggat aactgtgtat tagaaattac atgcttttct agggacgtgt 48960 gttttcatta tcagtttctc tctctcttct ttcagagcaa cacagcttct aaaggtaggg 49020 tgcagatcca tgacacacgc ccagtcaaac ctgaattggc attggtctac attgagtatc 49080 tgctgactca tccaaagaac cgcgagtgct tgctctctgc tcctcggaag aaacttaacc 49140 atcttttgaa agcccttgaa acgtcaaagg taactctgtg ccctgagagt tgagtggttt 49200 cctatgattg tgggggtgac aaatcaaagt gtgaagcttt catatttaca gtgctataca 49260 agtgttctgg ctggaacaga attgagagtg atcatgtcac ctcattcagt tggtacaagg 49320 catggagcct ggccagggca aggttgggag tcaagtccca gttgacacgt gttcagaaat 49380 ctcacatttg tgttgcacct gctagggcgc taggactcag gaggatggcc ccagtgtctc 49440 agaacacacc ctctgcagga gatgtgtcac ataccctttc atgtggacac tcactccctg 49500 cagtccttgg cagttttttc tgggaatgtt tggagagcat ttcctgggaa cccatcatgc 49560 tcccagctgt cccacggagg ccgtcatctc ttcctctcct ccaggagcca gccctctgaa 49620 caccctgtta cgctgccctc aagtgtgact gtaccagaag caaagcccca gcagagtgga 49680 Página 138

P201430887 ES 2 553 786 A1 09-06-2014 gccaggcaga tggggaggac ggggcctggt catgaggcag ggaggggacg ggtggtgctg 49740   cgtgcagggc aagggctgtg gacggtgagc tgaggctgct cacctggctg tacattttcc 49800 cataccaccc agcacctcat gtccgggtgc agagtcagca gacactgggc ttcaccagag 49860 cgggggtctt ttcagctcgc ctgaggatca ggtgcttccc attgttcttg ctgtacgggg 49920 tgtggtggtg ccttgtcagt cagcatgtgg cccttgggtt ttttctatta caggcagatc 49980 tggagtcact tctgcagaca ccgggtggga agcctcgtgg cttcagtgaa gcagctgccc 50040 cgcgagcctt tggtctccac tgtcgcctga gcatccatct tcagcacaag gtgtgcctgc 50100 tcctggccct ctattaggat gatacacagt gctctttttg ttactgattt atcttcttgt 50160 ttttggacag ttctgctcag aaggaaaggt gtatttgtcc atgttggaag acactggctt 50220 ttggttagaa agcaaaattt tatcttttat tcaagatcaa gaagaagact acctgaagct 50280 tcatagggtc atttatcagc aaattatcca ggttagaagt cttaagacac agaaaacttt 50340 ctctttacca agtttgttat gtttcaggat ttcattttct actttagagt ggtaatttta 50400 gacattagtg ttattcttaa aaacttacag ggacatttat ctaactttct agtttatctt 50460 tttgcaaagc gtaaactgca tactttcagt gtaattttat acattacata taagaggtgt 50520 tcgattatgt ttgtggaatt acataaaata tgtctctaga tttcttacaa aaacaagaat 50580 taatgtatct ttatgaaaat tcctttataa aacatcttta taaaaatctg ctttataaga 50640 taactagcac atggatagga gaagctttgt gaggctggat ttactccctt tttaaaaatg 50700 gcctttgttg ctaagctgtg tctgtctctt acagacctac ctgactgtgt gtaaagatgt 50760 tgttatggta ggccttggtg accatcagtt tcagatgcaa ctcttacagc ggagtcttgg 50820 aatcatgcaa acaggtacag tcagggctgt tttagagcaa taaatactca gaaccagtcc 50880 ttccctccct ccctccttta ctgtgtagct cagaactctc acttttaagt gactgattat 50940 aatgcaacct ggcatatccc aaaaaaggga tttgttaggt ggttcagccc ggaaattaag 51000 aggtgtttct gtgtcagaca tgactacatc cagagtttgt gacagggtcc ttgggattct 51060 gcctgtcctt gtggtcagct ttgttgccag gctgactttc cctgtggatt gggctagtgg 51120 ctatttcctg gcatctgtgt gggaaaccat cacctttttg ctctgctctg gtcatgtgct 51180 cctgtggatg ggggcgtgag tcagacatta ttgggtggta ccccaccagg acccccggaa 51240 gttgctgtta ccacagggaa agggttagca cagggtgacc catggcaaca gtgagtgaga 51300 ggacagccct cgaatcacat cagatgatga cgggaaaggg tgtggggcca gggggagtgc 51360 agctggggtc attccatatc tccttggcct tctgatcaca gtctggtaaa gaagagtact 51420 gctgagctgg gaccctggtc cctggcccct gacgcctagc ccctagcccc tagctcctag 51480 cccctactcc ctaaccccta acggccagcc tccccctcag ccgcttctgt ggtgtagctg 51540 actgctgtgt aaacctgttt ctggatggtt tttaagtagt atcccaatat cccagtgctg 51600 catttgattc tcactgagat ctgtaaaagc ctcaacattt gatgttgaca tttctttaag 51660 cctagttatt tgctagaaga gattgaaaat gataacattt agtaaattca acattaagtt 51720 ttgaaaatta gattaagttg gttgtccaat ttctagtgga tccatctgta gtctctttcc 51780 Página 139

P201430887 ES 2 553 786 A1 09-06-2014 catagcctta aatatcttca tggcagattc cagaggggtc tgtgtgtgtg gacaccccca 51840   gtgtatctgt cttcatgacg ttgcaactga agtagatgct aggagaacac tggagccagg 51900 atactgggca gtgtcttagt taatctttaa ttataagcaa aatcatccat catttgttta 51960 acagatctaa agtttaagag taaatattaa atagaccaat attatttgct tcagcttttt 52020 tgtttaatta ttattattat tttttttttt attttttttt ttttgagacc aagtctttct 52080 ctgttgccca ggctggagtg gagtgcagtg gtgcgacctt ggctcactgc aacctccacc 52140 tctaggttca agcaattctc atgcctcagc ctcctgagta gctgggatta caggtgccca 52200 ccaccatgcc tggctaattt ttgtattttt agtagaggtg aggtttcact gtcttggcca 52260 ggctggtctc aaactcaagt gatccaccca ccttggcctt tcaaggtgct gggattacag 52320 gcgtgagcca ccatacccag cctgtttaat tctttataat tcacttctgt tgtgaaaaca 52380 gcattttata cttaagctta atgattgcaa cagtcaaaat tatttatttt ttaaacttca 52440 cttatcattt aggaattatt ttcccgtaag gaccaaatct acttttatta tttaaaaaat 52500 ttactttttg gaggagctaa ttataactag aattctagat ctccagtgta gccagtttca 52560 ttgtataggt atatctgttc tcttaaaaat aaaacagaac caacaacact gttctctaat 52620 tcaggtgttg agggaaccac actgctgaac ttctgtatgt tcacatgtgc aatgaacaca 52680 atttttagtt tagtgactaa tacactatta ctgttattga agatatcagt tttaacttaa 52740 atgggacaaa cgtcatactt atttatttat tttggttaga atttaggtta acctgatcaa 52800 cctggctttt ggtattggct caccaaatac caaagtgtaa taatctcttt tttgttacca 52860 ttttatacat gtgttaagtg agaaatgtgt aatgatttca acaaacttgt gtgattagaa 52920 aactgatata ttccaatttt ctttctagtg aagggatttt tttatgtttc attacttctt 52980 gacattctga aagagataac tggaagttcc ttgattcaga aaacagattc agatgaagaa 53040 gttgcaatgc tgttggacac agtccagaaa gtatttcaga aaatgttgga atgtattgca 53100 cggagcttca ggaagcagcc ggaagaaggc ctgcgggtac tcagaactcc ccaggacggg 53160 gttcgctaga tgggcttttc agggctggct acacctacac agatgcatca gccctggctg 53220 tgctgttcac gctcgggtga cacgcagtgt tgtgtgggag gtccctgctg gcgaggtgca 53280 ctgagagaga tggagtccgt gtgggagtcc cccatggtgg atacactgag agggagatgg 53340 tgacccctgt gcatgggctg gaggcaggaa gggcaggagc tccagctgtt agattctacc 53400 caatggtctt agaacaggat cccaagagtt caggttgacc agacggcagg acaggaagca 53460 gaggactgat tgctctgggt tctgagcgca taattgttaa gttcacagag ttttccaaat 53520 aaaatatacc tttcttttga aagatgctaa ttttgatact tgtagagtgg cagacatctt 53580 gtcaggtgaa atgctaattt ctgtcatgag ttacctccct gtcctatgtt aaccttctcc 53640 aggttggaaa cgagagtcac agaccttgaa ggggcccgtg gcttcccttt gctggttgaa 53700 agctgatgtg aagtgagatt gttgtataag cacttcatat aaaaacctgt ctgccagatt 53760 tgcttcatcc taaaaacaat gtcatgtcag ttctcgtacc acgtgatgtt gttatcagag 53820 agagccatta ctttttctag gtagtagctt aaaaatatca atgagctatt attttttaat 53880 Página 140

P201430887 ES 2 553 786 A1 09-06-2014 gaagacttta aaaaatgctt aaatgggagg ctatttatga aatattgaag actcggtgtc 53940   ctttgctgat agaggtcatt gaaggttgtt ggccatactt tttctagtct agttcaattt 54000 gagttcattt gaaatgttcc tgtttttgat gaatttgttt caagtgcctg tgatctttta 54060 tgtaatttgt gccaaaacct ttaggtttcc catcagacct gtgtagcttt agtcagaata 54120 cattgcctca tagctgatgc cttattttaa tgtattgatg ttttgcctct ctccctcctt 54180 attcctgagg gtttttcttg gctttgggga aagaatatca tcagggcagt tcccagtggg 54240 ctttggtccc gtctatcatc ttctggccgt ggtgcatagg aggtttgagt cagcctggga 54300 gtggaatgta gtgggcactg gtagcaggca aacaagatca gtgactcctt gagtcctggg 54360 ggaggatagt aagaatactt attttaaagt gtttttttgt ttttttcaaa accatggttt 54420 ttagtcatta aaagtgacgt atgtgttttc ttgtagctgc tttattctgt tcagaggcct 54480 cttcatgagt tcattactgc tgttcagtct cggcacacag acacccctgt gcaccggggt 54540 gtactttcta ctctgatcgc tgggcctgtg gttgagataa gtcaccagct acggaaggtg 54600 aagtgcttta atcctgaaac tgctgtgcct cttattgatg acacaagatg gtgtttctac 54660 tagcagtaca ttctctacgt ttctcaaagt attttttaag aattttcaaa cttgagtgag 54720 tggtgcactt tcctagcagc tacacctcag agtttgatag ctagttagta ttttagactc 54780 gtgactattg tgaaacatat accaaggata ttatcactct tgattaaaac agaaatatag 54840 tccttacatt tgaacatgct tttatgctac attcaggaga tttaaatgag ttgataagtt 54900 tcttaaggtt attttccctc ctaaaaggat agaagtagtt gtaatcagtg gtgagcagaa 54960 tacaagacta ctctaggagt gcttttgtgg aatagttcac atatctttgc atgttatatt 55020 attagcctcc cccacctttt tttcatttct aagctaggat gttcaacctt ctaatgtcag 55080 tttagactgg gcgcagtggc tcatgcctgt aatcccagca ctttgggagg tggaggcagg 55140 tggatcatga ggtcaggagt ttgagaccag cctggccaac atgatgaaac tctgtctcta 55200 ctaaagatac aaaaaattag ctgggcatgg tggcacgcac ctgtaatccc agctgctcgg 55260 gggctgaggc agtcttgaac ccgggaggcg gaggttgcag tgagctgaga tcacgccatt 55320 ggactccagc ctgggcaaca gggcgagact ccgtctcaaa gaaaaaaaaa tgtagctaat 55380 atcagtttaa acagacaagt tattcattat tactgactat cttattttcc taccggtagc 55440 tgtagatgaa ttgaagatga ttattaatac agaagttatt agtctatttg gttaaaggat 55500 gttataatca ggatgataat tcaagccaaa acaaaaagtg gtgttttccc acatggaata 55560 ttcagggtgt tgttttcctc tttacctctt aagaaaatag taaaaaatca tgttttcata 55620 tagagaaaaa aacttctctg tatgaaaaga taaaaactga cagggaaggt cattgaatta 55680 tatgcatttt taatatttac gtgaatcata aattttgtaa tataaaatca tgactaataa 55740 aaagatgtta actaaattct aaaacatcaa atagaattta aggccttcct taaagcttga 55800 agggagatca ttttggtttg gaaagtaatt actagattac acaatagaat aaaaactagg 55860 atttgtttat tccggtgagc tatgtagcta aaaatgataa aaaaaatgtt tgacctgtga 55920 gtcacatctg gctcaccatc tgttttttat cagtaaagtc ttattggaac atagctgtgc 55980 Página 141

P201430887 ES 2 553 786 A1 09-06-2014 ccatttgccg tgttttttct ggctactttt gtgcagagtt gagtaattat gacagagacc 56040   attgcaactc tgcccacaaa ggtgaaaata tttactatac tatttaaata tttactattt 56100 tgttacttta cagaaaaagt ttgctgacag ctgttgtatt tccttatgga ttttgtctac 56160 ttattttata tgtgattgtg ggtttgtctc ttttttcatt tgttctgtca attttctttt 56220 catgtatttt cttgtatttg ggagcttttt ctttttgatg aattgactcc tattattgtg 56280 gaatctctct ggctctgact cctcatgaag tctactttga tatttttaca gccaaaccag 56340 ctttcttgtg ctttgtgttt gcatagccta tcttttaaaa cctcaccccc acatgggtag 56400 ggcttaaaaa atctagtcca acaacctctg acttttcttt gccgtggttg tagtccattt 56460 gccatggtta tagtccattt gccgtggtta tagtccattt ggcgtggtta tagtccattt 56520 ggcgtggtta tagtccattt gccgtggtta tagtccattt gccgtggttg tagtccattt 56580 gccgtggttg tagtccattt ggcgtggttg tggtccattt ggcgtggttg tggtccattt 56640 ggcgtggttg tggtccattt ggcgtggttg tggtccattt ggcgtggttg tggtccattt 56700 ggcgtggttg tggtccattt ggcgtggttg tggtccattt ggcgtggttg tggtccattt 56760 ggcgtggttg tggtccattt ggcgtggttg tggtccattt ggcgtggttg tcgtccattt 56820 ggcgtggttg tcgtccattt ggcgtggttg tcgtccattt ggcgtggttg tcgtccattt 56880 gccgtggttg tcgtccattt ggcgtggtta tagtccattc tttttttttt ttagtccatt 56940 tgactttaat gaatttattg ataggtttgg gtttaagtta atgttgtttc ttttctatca 57000 gtctgtctgt tctgttagtc tttctgtttt tttttctttc ctgtcacttt tatgatgaat 57060 tgtttttact acgccatttt atctctgttg actttatatt atcttttgtg taattttttt 57120 ttttagtgat ttctctagag atctcagcac gcatgtttaa cttatctcag taccttcaga 57180 aattatgctt gtccattgca tggtaggaat ctccagttgt gttctcctat cccttatgct 57240 gttgttatta tttttatttt aatctgtcaa tagtcttttg tctcactgtt taagaaatgc 57300 atttacaaca atcactttaa gatgtaaagt attttaatga gaaacagtgc tatttgatgt 57360 atagtgatga ttgacttaaa tattcaaatt tgtattataa tcctggcaga ggaagtgtgg 57420 gaagacttat tggaagtgct gtctaggcca ggcacggtag ctcacaccat aatcccaaca 57480 ctttgggagg cctaggcagg aggattgctt gaggccagga gttcgaggcc aacctaggca 57540 acatggtgcg accctgcctc tattaaaaaa tatttaaaaa ttagctgggc atggtggtac 57600 acgcctgtag ttttggctgc tcgggagact gaggcaggag ttcaaggctg cagtgagcta 57660 tgatttgtga ttgtgtcact gcactccagc ctaggcaaca gagtgagact atgtctctta 57720 aaaaaaaaaa agcagtgttg tttagtcatg cctaaatgaa atctcctaag atagccaaga 57780 atcgggccta acacagtggt ggagagatac aggggtagga taggcatatt catgtctcag 57840 ctattacagg tggaaaacca aggcataagt ttccacctgg agcaggaatt ctgcacttgg 57900 actttctgag gagcatgtgg aattcatggt gaaaggctca tcgaagctca caaggctgat 57960 aattaagagc acaggtccag gcaggtgccc tcgtggctct aaacttgcag tacttcactg 58020 tgggcttctg ccctgcaggg ggcactgtga tgtgtaggaa catttttgtt tggcacaact 58080 Página 142

P201430887 ES 2 553 786 A1 09-06-2014 gggtgagggg gtgggcaacg tgccccaggc attgagtggg tggaggccag ggatgctctt 58140   cagcctccaa cagcacctag cacagcctcc caatccccca aagaacgagc tggtcaggtc 58200 agtagtgctg agattgagaa acgccaattt agacaggagt acaatgttaa atttatttag 58260 cataaaagca cattatttac agtagatgat aacaagataa agactttttg atgaaagact 58320 tattgagtaa tatgtctgtt tttctttatt tttgtctcac tgaataaaca ctttcgttta 58380 tctttttttt ttttttgtca tattgagaca ggatgtcgct ctgtcaccca ggctggagtg 58440 ccatgataca tggctcacta cagcctcaaa ttcctgggct gaagtgatcc tcctgcctca 58500 gtctcccaag tagctgggac tacaggtatg caccaccatg cccagctaat tttaaaattt 58560 tgttagagag gcagggtctt gtcatgttga ctagcctgat cttgaactcc tgacctcaag 58620 cattcctctt gcctcagcct cccagagcgc tgggattaca ggtgtgaacc accacgccca 58680 acacacttat gtttataata atagattatt cataattatt gtagacattt caacagttaa 58740 taaaaataat tcttttgaat ttctagaaag tttttcttag gtgttgaaga aaacccaaag 58800 caatgtaatt tacaagtaag tagcctagtc tctgtttaca acttgctgat ttggaacttt 58860 tttaggtttc tgacgtagaa gagcttaccc ctccagagca tctttctgat cttccaccat 58920 tttcaaggtg tttaatagga ataataataa agtcttcgaa tgtggtcagg taatcacttt 58980 ctctttactg tcctgaaatg ctcatcgtgg ctgtaagcgc tcagcagctt ttgttctatt 59040 ccttttacac tcaagttttt caaagctaca ttcttttcta tgagaaaaat gtttcatata 59100 attttttctc cattttatca gtaattagaa atatttacat taaacttaca cagagaaaaa 59160 ttctaacttt ctgtaaagaa tattcatcta aatagtctct ggttagttat gcttctcata 59220 acttaaattc agttaaggga gaatatagaa tgttaatgtt tagtaaaata cttcttacca 59280 agtgtgcttt caaaacactt gacaaggtta aataccggtg ccattttcgt tgaatacgca 59340 gctgctactc attttccagt ccatatgtca cttgatcaga attacagggt ttgctgtggt 59400 gcatgcaggg ctgacaggtt acagagggaa ttgctttgca gatgtctggt acctgtcgaa 59460 ttttaatagc agatacattc aatgaaaact tttaaaagca ccatctttag cagctatgag 59520 tcatctttca acaacatatt aaatcttttt tgtgtgcatt gagggtatac agagtagcct 59580 ttttcactca gcacagcatc cctgttccca gcagcatcct ctggttttaa tatctcactg 59640 tacaatctgg cacactctcc atgaaaagca tggggtgagt tcagtcacct tcccacgtcc 59700 cctgcaaact ggggtttgtg gttgtggttg aaccttggct gtacttctgc tataatgtat 59760 tagggtctat atgatacagt aattttgatg tttgttgatt tttttgcagg tcatttttgg 59820 atgaattaaa ggcatgtgtg gcttctaatg atattgaagg cattgtgtgc ctcacggctg 59880 ctgtgcatat tatcctggtt attaatgcag gttggttaca ttcccctctg tcatctggaa 59940 ggtggctggt gcacctcaca ggtgctgtca tgggattccg gggatcagcc cctgcacttg 60000 gctactcctg gccagctcag gtgtccccca gcctttccac tccctgcctt ctcatgtgct 60060 ggacacagtg ctgtccacct gggcttcctc tccttagccc accctgcatc tgtttttata 60120 tcagcttgct cactcttcag tggtggaggt cctgttcatt ttcacctgtt gccactaggt 60180 Página 143

P201430887 ES 2 553 786 A1 09-06-2014 ccatttaagt gttcctgtct gtgcctcggc attgaatttc tgttgatttg atgtgttacc 60240   tgtatcttaa aatctgaatt tattttggtt gatgacggat attttggtgt taatatttga 60300 cctatctact atttctcgta agccttagcc ttgcctattc tgaatatccc aaccagttca 60360 agtagtactg ggaaaataat tggagatatg tataagatgc ttagctcagt ataaaatgta 60420 gtaacatccc tgcagggtga ctgcctttac ctttctgtat tatttgctca gttttactaa 60480 cgttgaaatt attttcagag atgatacatt gtagataggg agtgcttcta ttgaaacaaa 60540 ctctccctgt aagcctaaat ggataggata tctgcagatt gataagaata ctccttaact 60600 ggtttgaccc aggttgggca taagaaaaga cttccctcag ggactcccct gcattgagat 60660 caccaccagg aggatgttga ggatggatgt tggatgctgc caggtgcctt gcccttaata 60720 catccttaac tacctgcgat agttaaacag gggaaggact ctgaaacagg attggtttgc 60780 tggcatggac ataatccttc ctctcatggc ttcatggggt gaggtccatt tgaagtcttc 60840 ttcccagtaa acgtttgttt gatctttaca acatccctaa agaagggaga attactattc 60900 cgcgggtcag tatgtaggtt acctcaaagg gaaggatagg gaggcccagc ttagggaagt 60960 tgtaccacat gtgtaccaga gtgtttgtct ttgtgtagtg atgttaaagt cttttctgtc 61020 ttttaatata attttcccag gtaaacataa aagctcaaaa gtgagggagg ttgcagccac 61080 tgttcacaga aaactaaaga cattcatgga aattactttg gaagaggata gcattgaaag 61140 gtaaaggaga gatattcacc agatgtgatc atctaaaact gctcattctt ctttggatct 61200 gcatgaggtt gtattttcat ttctgctact tacacccagg tggttaggag actggggact 61260 ctaaggagag aaatgtttct gttggcaaag acctttagct tacgtttaat ttacttgcta 61320 attctgtctt caaaaacaaa acaaaagtgt catttgcaaa attctactgt agaaaagtga 61380 gggcatacaa acttatttta tttagtttta aaatcagaca ttatttttgg tggttgctgc 61440 attattgaaa ccatgggcgt ttcccaagga tagacaccta gcggacaaat acccacatgg 61500 ggatgtgcgg tccctccaga gcctctgaga tgtgtgtaat ttcccccttg ctggacagcc 61560 cattgctacg cacagcctgc aggctaccag tgtattcgta gggctgcttt gcagctgggt 61620 gtttttgctg ctgtgtgctg tttggtatgc tctgcatttt actatagact cggttttgaa 61680 ttgtgtttga cttttagatc aaccacaaag aatttttctt gctattttat gagctaaata 61740 ggtgaagcgt tgtaaagctc tgcactagga aattcacctt tgccagggaa acaaaccact 61800 ctccatagct acttcctctg gagaaaggtt ttccaaatca gaaactccta atttgtgaat 61860 aaacttccaa agcgtggctt tttatagact gttggcttgt tctatagaca caatacactt 61920 aatgctcact tcactagaaa atttggtttg taggctgggc gcagtaactc aatgcctgta 61980 atccaggagt ttgagaccag cctggccaac atggtaaaac cccatctcta ctaaaaatac 62040 aaaaattagg ctgggcacgg tgactcatgc ctatagtccc agcactttgg gaggccaagg 62100 caggcggatc tcaggaggct aggagtttga gaccagcctg gccaacatgg taaaaccctg 62160 tctctactaa aaatacaaaa attaggcctg taatcccagc actttgggag gccgaggtgg 62220 gtggatcacc tgaggtcggg agttcaagac cagcctggcc aacatggtga aatcctgtct 62280 Página 144

P201430887 ES 2 553 786 A1 09-06-2014 ctattaaaaa ttacaaaaat tagctgggca tggtggcagg tgcctgtaat tccagctact 62340   tgggaggctg aagcagaaga attgcttgaa cctgggaggt ggaggttgca gtgagctgag 62400 attgcgccac tgcactctag cctgggcaac agagcaagag tccatcttga aaaaaataaa 62460 taaaagtaaa aaataaaaat aaaataatta gccgggtgtg gtggcacgct tctgtaatcc 62520 cagctactct ggaagctgaa gagcttagtt agcctggcta gaggtttatc aatttttact 62580 gatattttca gagaactagc ttttggtttc gtttattttt tctgttgatt tcttattttc 62640 aagtatatta atttatgctc tagattttac tgtttctgtt tttcttactt aggatttaat 62700 ttgctcttct ttttctgttt tccgaaggtg gaagtttaga tgattgattt tagatttttc 62760 ttcttttcta atatgtactt tcaatgctat aaattttcct gtaagcactg ctttattccg 62820 cattaaaaaa cttttttttt ctatttatct ttttgtcctt tttcttccca tcagttttta 62880 ttttgttttg ttttttgttt tgagatggag tcttgctttg tcacccaggc tggagtgtag 62940 tggcacgatc acagctttaa cctcccaggc tccagcgatt ctcccatcta agcctcccaa 63000 gtagctagaa ctacagaagt gtgccaccat gcacagctga tgaaaaaaat ttttttgcag 63060 agatggggtc tcactatgtt tgcccaagct gtccttgaac tcctgggctc aaacaagcct 63120 cctgcggcct cctaacgttc tgagattacc agtgtgagcc accatgtttg gcctttccat 63180 cattcttgct tcccttttat gcatctcaca aatttttgat aaactgtgct gtcattttta 63240 tttagttcaa aatattttta aatttctctt gtgatttcct ctttgaccta tttagttgcg 63300 ttgtttaatc tccaagtgtt tggggatttt tccagctttc tgttattgat ttctttttta 63360 attccattgt agcctgagag cagacattgt attgtttctg ttcttttaaa ttcgtgaagg 63420 tgtgtcttat ggctcagaat gtgttctctc ttggtgagtg ttcatgtgag catgaggaga 63480 atgtgtattc tactgttgct ggaggaagta gtctgtagac gtccattata tccaattgac 63540 aatgtttttg ggttgaacta tgtccttcct aattttctac ctgttagatc tgatagaggg 63600 tgttatagtc tccaactata ataactgact tatctattac tttttgcagt tctgtcagtt 63660 tttgcctcac acagtttgat gctctgttgt taggtccaca cattgatgat tgttaccatc 63720 ttttcattat gtaatgctct tctttatctc tgataattct tcttactgtg aattctgctc 63780 tgcctgaaat taatactact actcctgctt tgttttgatt agaataagca tggtatatct 63840 ttttattcat ttcctttttt tttttttttc caagatatga ggacttgctg tgttgcccag 63900 gctgggctct aactcctgga ctcctggact caatctatcc ttctgcctca gtcccaattg 63960 gctaggactg caggcacaca ccaccagacc cagctaatgt aatttctatc tatatgtgtc 64020 tttatattta aagtggtttt tttatagaca gtatataaat gggtcatgtt ttttgatctt 64080 ctctgacaat ctgtcttaaa attggtgcat atgtaccata ttcaaagtga ttattgatat 64140 agttggatta atatccacca tatttgttat tgtcttctat ttgttcccct tgttatttgt 64200 tcctatttct gtcttccact ccttttctgt cttttgtggt tttaactgaa cattttatga 64260 tgccgttttc tttcctagca tatcagttat actttttttt ttttaaacct ttcttagtgg 64320 tttctttaga gttggaattt ttatttgttt ttatctttct tagtggttgc tttagagttg 64380 Página 145

P201430887 ES 2 553 786 A1 09-06-2014 gagttttcat ttataactaa tccacgtttg ctttcagatg acactatacc actttgcagg 64440   tagggtggta tataataaca aaataatcct aatccttgcc tctcgttcct tgtatcattg 64500 ctgtcattca ttttgctaag gtataagcag acataagcat acataattga atatattgtt 64560 gctattatta ttttgaacaa actacatctt aggtcattta agaataagaa aaataaaagt 64620 ttttatttac cttcacttac tccttctttg atgcttctcc tttgtttgtg ttgatccaaa 64680 ttctgaccta tattcttttc cttccctcca gagaacttct tttaatgctt ctttcaaggc 64740 atgtctactg gcaactaatt ctcttaattt tggtttgtca gagagtcttt tacttctact 64800 ttatttcttt gcagggataa tgttatgtag tttataattc tagttgatga atttttttct 64860 ctctgtactt tatttaattt attattatta ttttttgaga cagagtcttg ctctgttgcc 64920 tagggtggaa cgcagtggtg tgatctcagt tcactgcaac ctctgcctcc taagttcaaa 64980 cgattcttgt acctcagcct gctgagtagc tggtatacag gcacatcgcc gccacaccca 65040 gctcattttt gtattagtgg agacagggct tcaccatgtt gcccaggctg gtctcgaatt 65100 cttgatctca agtgatctac tcgcctcagc ttctcaaatt gctgggatta ctccccgtgc 65160 ccggccactc tctgtacttt aaacatttcg ctatactctc ttcttggctc gtgtagtatc 65220 tgagaaatag gatataattc ttttttgctc ctcagtagat aaggtgtatt tttccctatc 65280 tggtttcttt caatactttt tctttgtttg atttttctgt aggttgaata tgatatgcct 65340 aggtgtagtt ttcttttctt tttttttttt ttttttggca tttattctat tcagtattct 65400 atgagcttcc tggataaatt ctcagttatt attgtctgaa tatttcttct gttcctttct 65460 ctcttctgaa attcttatta tacatgttaa caccttttac agttgtctca caggtcttgg 65520 atatttcatt ctatcaaaac agctgcattt ttgaattctg tttgctaata ttttatttga 65580 gaatgtttgc attaggtttg aaataagatt aaatggttgt tggttgtttt gttttgtagt 65640 gttttgtttt tgttttttca gtaggacctc taccagtttt gctctcagca ttagttggta 65700 acttctccct tttcagtgtt gtggagcagt ttaaatcaca tctgatgctg tggaacaaca 65760 tacccccaga aatctgggat gacttttccc tgtttcttct atgttagtag ttgggtctga 65820 tttcctatta ctgcctgaat aaattttggt aatttacaat ttcttgcatt ggtctagatt 65880 tttaaattta ttaacaaaat ggcttgtggt ttttgtttat tgattttaat agaatagaat 65940 ttactcattg agatatacat atggaaaaga atgtaaataa tatgtgtacc actgaattaa 66000 ttgttataaa atgcactcac aagccaggtg cggtggctta cagctgtaat cccagcactt 66060 tgggaggcca aggcaggtga attgcttgag tctaggagtt cgcaaccagc ctgggcaatg 66120 tggcaaaacc ctgtctctac aaaaaatata gaaattagtt ggatattgtg gcactcacct 66180 gtggtcccag ctacccaaga ggctgaggtg ggaggatcac ttgagcccag gaggttgatg 66240 ctgcagtgag ccgagatcac gtcactgcat tccagcctgg gtgacagagt gagaccctgt 66300 cttaaaaaaa aaaaaattca gtcaccacct aaatcgagga atacacctcc tgaacatggt 66360 ccctctctcc ctgtttgaag gtatcagccc accccaatac ctcagtataa ttttgggcat 66420 tgtccggatg aagagcaaag tgtgtgtggt tttatacttg atatgaggtt tatgtttact 66480 Página 146

P201430887 ES 2 553 786 A1 09-06-2014 gtggctttta acaccatttc ttttttgtct tttttgattg tacgtctgag actggctctg 66540   tggctcacac acagcatttg tgagtgcttg tgcataggag tgtgtgtttt agagaggtgg 66600 agtgccacct gatcagttca cgttcgttaa ttgtgttacc tcaacttttc tatgttttta 66660 ctgatttttt gttacttatt ctacagagac ttgtgttaaa tttctcatta tgcttgtgaa 66720 tttgtccaag tatcatattt aggactgctt ttgcattata tattttatgg ccctgttatt 66780 aggtgcatat aagtttagaa ctgctgtatg ttcttgatta attgaccctt ttattttaat 66840 aaagggtctc tctttactcc actttgtcag gtactgagat aacaatgttg gctgggcatg 66900 gtggctcgcg tctgtaatcc caacactatg ggaggctaag gtgggtggat tgcttgagct 66960 caggggttca agaccagttt gagcaacaca gcgagacctc atctctacaa aaaatacaaa 67020 tattagacag gtgtggtagc atgtgcctat agtcccagct acatggacag ctgaggtggg 67080 aggattgctt gaggtggagg ttgcagtggg ttgagattgc gccaccgcac tccagtcttg 67140 gcaacagagc aagacttgtc tcaaaagcaa acaaacaaaa aacaatgttt ttctgtgtgt 67200 ttgtcaggtt ccaggagaag accaaaacca cgcagtgatt cggataggga aagctcagtg 67260 tcagggattt ttttgtttgt ttttgagaca agagtctccc tctgttatgc aggctgtagt 67320 gcagtggtgc gatcttggct cactgcaacc tttgcctccc aggttcaagt aattcttgtg 67380 catcagcctc ccgagtagct gggattacag gcatgcgcca ccatgcccgg ctaatttttg 67440 tatttttagt agagacggag tttcaccatg ttggccaggc tggtcttgaa ctcctggcct 67500 caagtgatcc gcccgcctcg gcctcccaaa gtgctgggat tacaggggtg agccaccgtg 67560 cccagccaag tgtcagggat ttttataggg agttggcacg atgggttatt ggctagtgag 67620 agttaaagag aactctagag aatacaggac tagcagatga agagaacacc tccaacccta 67680 ggtgagcgcc gccaaggaag gagcccccac ccggacaggg agacctggct tcctacgtgg 67740 aagaaattgt tagcggcctt ctgtgggacc tgaggacgtc cactcacctg ggtgggtggt 67800 gggccggggg gatgtggagc catcgcaggg gaggtgctgg ggagctgctg gagccggagc 67860 tggaaagcct actctcttga gtcccacagg ctcctgtgtg tggctcggat ggggtggggg 67920 cttgtggggt agttgtctgg tgtgctgctt gtgctgtcag agtctgctgg agaaaggggg 67980 gccttacgga aacctggaga aagtcccctc cttccccagt gaccttccag caccccacgg 68040 tgatgggacg ttgaactggg cactaaagca ggtgggtggg tttgggctcc tagcgactga 68100 gtgaatgaaa tgcattcaat tatgtacttt attctaaaaa tgattgagtg tccactatgc 68160 tagttttaat caggttagac tttgcaactt tatattttaa gaagaaaccc tctcagcact 68220 ttgggaggcc aaggcaggtg gatcacgagg tcaggagatc gagaccatcc tggctaacac 68280 ggtgaaaccc cgtctctact aaaaatataa aaaattagcc gggcatggtg gcgggcgcct 68340 gtagtcccag ctgctcggga ggctgaggca ggagaatggc atgaacccgg gaggcggaac 68400 ttgcagtgag ccaagatcac accactgcat tccagcctgg gtgacagagc agggctccgt 68460 ctcaaaaaaa aaagaagaag aagaagagga aacccaatag actattggcc ttaggagctt 68520 gtttttaggg cagtggtctg atttggggat gacagaggag cacttgtcca tttcagaaaa 68580 Página 147

P201430887 ES 2 553 786 A1 09-06-2014 taagtggcaa tgatgtaaat ggtccatcag gcacaaatat taaacaagat gaccagaatt 68640   accaactgta agaatgttaa attgttttca caggatgtag taacaacctc aaaagtctaa 68700 gcatttttct ttattagaaa taatgttggc cgggcacagt ggcttatgcc tgtaatccca 68760 gcactttggg aggctgaggc aggcagatca cctgaggtcg ggagttcaag tccagcctga 68820 ccaacatgga gaaaccccgt ctctactaaa agtacaaaaa ttagctgggt atggtggcac 68880 atgcctgtaa tctcagctac ttgggaggct gaggcaggag aatcacttga acccggaagg 68940 cagaggttgc ggtgagccca gatcgagcca ttgcactcca gcctgggcat taagagtgaa 69000 actccatctc aaaaaaaaaa aaaaaagaaa aaaagaaata atgttgccaa ggaaggctta 69060 tttggatata gaatagtgta tactattctg aagatgaaag ggaagaggaa cattggtttc 69120 tcactaggaa tgccttccat ttccacttat acttagtttc aggctaacta cttgaattat 69180 gttagttaca ttgagagaag aaaagacctg agaaattcag aacttacaat gtggaaaagg 69240 acatgaacag aacactgggg atggagcgtt ttgtttctcc attattcacc tgcatgccat 69300 cccctctact aagatgatac acagatgaaa aaaagagctc ctccctttaa gaaggaaaca 69360 tcctagaaaa taaataggtc aggactgtga aatattggct tcttacttaa atatgcaaga 69420 agcaaactat agaaaaacca gtgtctaaaa aaatcaatct gacaaattga tgaaacaaga 69480 aaaatcaatc taacggaaga taaacaatta agatttaaga ctgtatttta aaatattatt 69540 gatttaacgt tggactagag acattaaagc aagtaaacat ctttaagaat ctgggaaccc 69600 cttgctccaa ttaatatttt aggcagtgga gcttgattta aaagtgcacg ttttcttaac 69660 aactaatcta gttttcaggg ctagtattct gttgactggt ctgtcttttg ggtgctaaat 69720 aaaaatcggc atctcattgc attttaattg cctcatccga tatagcatat tgtaaactgg 69780 acattttctg aggagaaaca acatgcattt gcccatgcac tggtgcattt aaatgtcaag 69840 tatgttaaat ttattgcttt cataaattgt atcgatagta ataaatttgt aatttgaaat 69900 aaattacaaa tataaataat atatttctta aggtttgtgt tacctcatga attttcccca 69960 ctaatcatat tacaagcaaa ttacttgcca atattaattg tgcctctact tgcaggcaac 70020 gttaatagta aaataatgta ggtgccaaca ttaaaccttg aagggaaaga gtactccctg 70080 aaaatggcct ctcttttgtt atcaggtatt gataaatgaa tatcaattca ttttattctg 70140 ctttaatttt aacagtcttt ttttttaaac gaatttgagg ctggatgctt tttatagctt 70200 atttagtggt atgcttccat catccatacc caatgaaatt ggtgtggata atttaaaagt 70260 attcatgtgt aaaaccaccc tttaataaat acagacactg tctttttatc ttacggtttt 70320 tctcaaaaaa ttgattctgc tgtgtttctt gtggctgtga tcaccaacat gtgatcctaa 70380 cctgacatag aaggaaaggt ggcgaagttt tgagtcctcg tgtttgacac attttacaga 70440 cgttagtgct gaggggactt gcacatggtc tggtctgtgt gtcttgttac atatcaggag 70500 aaccctggcc cagggagctt tttgtctaag ctttttgtca ctgtcccttc caactttaaa 70560 attccttcat tttgttttct tcatttgttc tttagtagtt cttatttctc tgatttacat 70620 agtgtgttca attcttgctt caggtaatag aagaatgagt aaatttgtat tgcagtagtg 70680 Página 148

P201430887 ES 2 553 786 A1 09-06-2014 ttccagtagc aggagaaaaa tggcctgggt ttaaacccag actgcccttc ccatctgagt 70740   ggtcatgggc agtttgcttt accacttttg cctcagttag cttatctgtt acaggataac 70800 gataaagagt cattcttgtt gccagtctag acttaggtca gtgtaagtag ctctttacta 70860 cctggtaaat gagaacactt ggccctccgt atccatgggt tccacgttcg taaatccaac 70920 caaccatagt ttgacaatat ttgggacaaa aatggatggt tgtgcctgta ctgaatatga 70980 acagactttt ccttgtcatt attccctaat ataatataac agtataggat aaacaatata 71040 gtatatagta taacaactat tagtatagta taacaatata gacgatatag tatatagaca 71100 atatagtata acaattatta ccatagcatt taccttgtat taggtattat aagtagtcta 71160 gagatgattt aaagcataca ggaggatgtg ggtagactat atgcaaacac tataccaggg 71220 acttgaacat ctgtggattt tagtatctgg ggggtcctgg aacacatctc ccacagatag 71280 tgagggttaa ctgtactttt aacgtaacat ttttctctaa agtattttta aattcatgtt 71340 cacttaagga gacaatatta tttttgagta attaaaaatt aattttaggc caggtatggt 71400 gtctgtaatt ccatcacttt gggaggctga ggcgggcaga ttgcttaagc tgagttcact 71460 actagactgg gtaacatggt gaaaccccat ctctacaaaa aatacaaaaa aatctgctgg 71520 gtgtggtggt gtgcaccata gtcccagcta cttgggaggg tgagctggga ggattgcttg 71580 agcccgagag gtcaaggctg cagtgagctg tgacctcact gctgcacttc agcctgggtg 71640 acagagcgtg accctgtctc aaaaaaaaaa attaatttta gattttggag ggttcatgac 71700 ttcctgggcc tgttctcctc tgtcttgcct ctggctgcac tgctgctgag ccaggcagtt 71760 gctgggctga caggtgggcg gaacctggtc tgtggacaga gagcactctc ttctccttgg 71820 gggactcagg gaatgggcag gagaccctga ggcagcaggt ccagtagagg cccagcgagg 71880 ctgggagagt gaaggggctg tggggcaccc agagtctcct gtgtcgctgc atggcagcct 71940 ccacatagct gtgccctcac ccctggttca acacaggcag aaataaccac acagagggtg 72000 gcccaggcgc ttccagagtg atagtggtgg gtgagtaata agagtctttg aagaagagtc 72060 aactgtaacc ccgaaaggac agtctagagc tcaagtgtca cagacacact acagagatgg 72120 ttcctgtgat agtcaaattc cagaaaggtc aatttggaga gatgtctcag aacatagacc 72180 ataaatactc acgaggagag gtcacgaggg tggggataga cttgggggaa aaggcccgag 72240 agacctaaca gcaaggagaa gcagtgattc aacaacgata ggaaaaaatt ccccagagct 72300 taaagaaata tatgcagatt cccttttttc tttcactaca ttctggattg atggaaaaaa 72360 aaaatcacag ctaaataatt atggataaga ttcctaaatt ccaggaataa agagaaaatc 72420 ttaaaatttt tctagattca tgcaggccaa tacagtggct gctgaacaca tgaaacctgg 72480 tgagtctaag ctgagtgtgg ccctcataga aagtgcaagc aggttttgaa gacagtatgg 72540 aaaagagaat gtgaactatg tcataaataa ttttatattg attacaagtt gaagcatttt 72600 ggatatgttg ggttaaataa aatatattaa gatgaatttt gcttaaaaaa ataaaaagaa 72660 gcaaggtctt gatccattgt accctttgac ctgtttcaat gtgattactg gaaaatgtaa 72720 aatgacgcat gtgactggca ttgacattac aggggctgtg gtagacagca gtctgtctcc 72780 Página 149

P201430887 ES 2 553 786 A1 09-06-2014 aaaggtgaag accaggtaga catgagtctc acttgcagtg ctggacacag gaagacaata 72840   ggattgtaag agttttaaat ctcgctgaga ttcatttgga gtgaaaggta gatatttgtg 72900 tccaggagga attcagagat gagcttttct ttattgcttc tctgaggaga ctgctttgga 72960 gtgccctgta atggaacaag cattggagcc atgcaggagt tgtgggacag taaaaaggga 73020 agccatggtg agccacgcac tttgtaaata tgtgtatttg aaggaacagt gatatgctac 73080 ctgtctaata atgattctta aaataggcac actgccaggg aagtgaggac aacgtctggc 73140 aaggaaaagt actcagtgct ctcagccaaa gccgcggcct aggtggggct ggggaggacg 73200 tgaggaggaa gagtctcgcc ttgagggaca gggatgtagg gcaggggagt gggaaagtga 73260 ggtttttcta aaggcttcag gttattagag gtagtaggta aatgtcatgg tagtagagta 73320 tcttggtagg tcacatagtt tttatttatc ttgttttctt gtgtaataga gaaataggct 73380 cagaactgtg ggtgctggaa aggaagagca cacgtcctgt ttgctcacca gcatagcaca 73440 ctgcccagtg agcacgtttc attgcctggc agtgcttggt gtccacggtc aacccaagcc 73500 tgtgctccag tgccatgtgt cctgactgct gtggggattc tgactccatt ttacatacaa 73560 gaaacaatta atgaaacatc tatagattat ttcaactttg tttttaaatg catggttgca 73620 aaccattttt agattatatt tttgaaaatg tacatttgga taatttggtc acttttttct 73680 gtagctaaat atttctttat ttgtgtttca gatttctcta tgaatcatca tcaagaactc 73740 tgggagaact tttgaattca taaccaagcc aacatctcca gacatgtaaa aatagggaaa 73800 agtgattcaa attgaaatgc ctgtgtattt tcctattgtt tttaatgtta ataacccata 73860 taatagggaa agggtgggat ttttttgtgg gaatgtggga aggtgggggt tatggaggag 73920 ataactcaaa acttcttcaa ttttgcctag tgcctgcgta aataatatat ttaatataaa 73980 ggactccagg tatgaatggt gtagaaatcc atgattccaa gaaaaaacac ttttctagca 74040 aacctggttg tttttaaaat gacttttata tatgtaatat tgcttggaaa ctatgagtaa 74100 taaagcaatg acaacatcca tttgtttatt tgaaagtatt aggggcccgg cgcagtggca 74160 cacgcctgta atcccagcac tttgggaggc tgaggcaggc agatagatca cttgaggtca 74220 ggagttcaag accagcctag acaacatggt gaaaccccgt ctctaccaaa aatacaaaat 74280 tagctgggtg tggtggtgaa tgcctgtaat cccagctact caggaagcag aggttgcagt 74340 gagctgacgt cgcgtcactg caccccagcc tgggcgacag agcaagactc tgtctcaaaa 74400 aaaaaaaaga gaaagtatta cctttatggc caggagtgag gtgctgtgat actccctgag 74460 tggagagccc agggcagggc ccacagcagt ctctgggtcc aaccttcatg ttgcctctat 74520 gggtattggg atgggtcctg tggctgtgaa cgtgagcagc acagacacca agtagctcag 74580 cctaaaggca aacactgtta ctctggtctt ttctttctga gagctgttct ggtagcagtg 74640 gtgctgacag cctcctaggc tgccctgacc tctcgcccac ctggtggatg ccagttgttt 74700 catggcccca tgctcctg 74718 <210> 12 <211> 19544 <212> DNA Página 150

P201430887 ES 2 553 786 A1 09-06-2014 <213> Homo sapiens   <400> 12 aatctgtaaa ttgttcccca aatattccta agctccatcc cctagccaca ccagaagaca 60 cccccaaaca ggcacatctt tttaattccc agcttcctct gttttggaga ggtcctcagc 120 atgcctcttt atgcccctcc cttagctctt gccaggatat cagagggtga ctggggcaca 180 gccaggagga ccccctcccc aacaccccca acccttccac ctttggaagt ctccccaccc 240 agctccccag ttccccagtt ccacttcttc tagattggag gtcccaggaa gagagcagag 300 gggcacccct acccactggt tagcccacgc cattctgagg acccagctgc acccctacca 360 cagcacctct ggcccaggct gggctggggg gctggggagg cagagctgcg aagaggggag 420 atgtggggtg gactcccttc cctcctcctc cccctctcca ttccaactcc caaattgggg 480 gccgggccag gcagctctga ttggctgggg cacgggcggc cggctccccc tctccgaggg 540 gcagggttcc tccctgctct ccatcaggac agtataaaag gggcccgggc cagtcgtcgg 600 agcagacggg agtttctcct cggggtcgga gcaggaggca cgcggagtgt gaggccacgc 660 atgagcggac gctaaccccc tccccagcca caaagagtct acatgtctag ggtctagaca 720 tgttcagctt tgtggacctc cggctcctgc tcctcttagc ggccaccgcc ctcctgacgc 780 acggccaaga ggaaggccaa gtcgagggcc aagacgaaga cagtaagtcc caaacttttg 840 ggagtgcaag gatactctat atcgcgcctt gcgcttggtc ccgggggccg cggcttaaaa 900 cgagacgtgg atgatccgga gactcgggaa tggaagggag atgatgaggg ctcttcctcg 960 gcgccctgag acaggaggga gctcaccctg gggcgaggtt ggggttgaac gcgccccggg 1020 agcgggaggt gagggtggag cgcggcgtga gttggtgcaa gagagaatcc cgagcgcgca 1080 accggggaag tggggatctg ggtgcagagt gaggaaagca cgtcgaagat gggatggggg 1140 cgccgagcgg ggcatttgaa gcccaagatg tagaagcaat caggaaggcc gtgggatgat 1200 tcataaggaa agattgccct ctctgcgggc tagagtgttg ctggggccgt gggggtgctg 1260 ggcagccgcg gagggggtgc ggagcgtggg cgggtggagg atgagaaact ttggcgcgga 1320 ctcggcgggg cggggtcctt gcgccccctg ctgaccgatg ctgagcactg cgtctcccgg 1380 tccaacgctt actggggcag gagccggagc gggaagaccc gggttattgc tgggtgcgga 1440 cccccacctc tagatctgga aagtaaagcc agggatgggg cagcccaagc ctcttaaaga 1500 ggtagtcggg ccggtgaggt cggccccgcc ccggccccat tgcttagcgt tgcccgacac 1560 ctagtggccg tctggggagc cgctagcgcg gtgggagtgg ttagctaact tctggactat 1620 ttgcggactt tttggttctt tggctaaaag tgacctggag gcattggctg gctttggggg 1680 actggggatg gccccgagag cgggctttta agatgtctag gtgctggagg ttagggtgtc 1740 tcctaatttt gaggtacatt tcaagtcttg ggggggcctc ccttccaatc agccgctccc 1800 attctcctag ccccgccccc gccaccccac ctgcccaggg aatgggggcg ggatgagggc 1860 tggacctccc ttctctcctc cctcgccctc ctcctgtctc taccacgcaa gccactcccc 1920 acgagcctgc cctcccgatg gggcccctcc tattctcccc ccgccctccc cctctcaccc 1980 tgtggttttt atttcacttg gcttcagcgc caatgggctg aggttggagt tggaagccac 2040 Página 151 cgcggactaa agctttgttt aaattcctga gaactggaaa gagttacagc ctccctggcc 2100 aggcgcctcg gcgctgtcac ccgcgctgat gaggagcagg cgagctttta aggatttgag 2160 gaaagaagaa cggggggagg ggcgggaagt gaaaaatcca agtgtgcctc ttagacccgg 2220 gggaaaggtg gttaagctgg gggttgcagt cactactgac aacgcccctc ttccgcctgt 2280 cccagtccca ccaatcacct gcgtacagaa cggcctcagg taccatgacc gagacgtgtg 2340 gaaacccgag ccctgccgga tctgcgtctg cgacaacggc aaggtgttgt gcgatgacgt 2400 gatctgtgac gagaccaaga actgccccgg cgccgaagtc cccgagggcg agtgctgtcc 2460 cgtctgcccc gacggctcag gtgcggctgc gctcggggcc tggggcctgg ggcctggggc 2520 ctggggcctg gggctggggc tgggggtggt cggcgctcgc tggccctccg tgctggaggc 2580 ctctgccgac gggagcagca ttagcaaacc ttggctctaa cgcgcgtctc ttcgtcccct 2640 agagtcaccc accgaccaag aaaccaccgg cgtcgaggta atctcctgcc ctcgaatttt 2700 gcccctgcgc ggcccgtgac tcctcacagt cctcccttct ctaacctggc ctcttgtttc 2760 ttctccccca atcccacagg gacccaaggg agacactggc ccccgaggcc caagggtaag 2820 cgttgcactc tgggctgtgg ggggctgcag gtgggcatgg ctctcggccc cacgctcacc 2880 ccggccccgc cctctccccc tgcagggacc cgcaggcccc cctggccgag atggcatccc 2940 tggacagcct ggacttcccg gaccccccgg accccccgga cctcccggac cccctggcct 3000 cggaggagta agtggagagg ccttgtgtgt ccactctccc ctgttttgtt tttgtttttt 3060 ggcagatgac ataattttat actttgaaat aatttcaaac ttacagaaaa gttgcaagaa 3120 tcctacagga aactctcaca tacccttcac agtttgtgac atgtgcttta ttagtctctg 3180 tttatgtata tgtatctttt tttttctgaa ctgtttgagc aagttgctaa catcaggctc 3240 ttttgcgcct aaatacttag gtgtgttttt cctaaaaaca agagcattct cttaactgac 3300 ctacacaatg attaaattca ctctctaatg tgcagtccgt attcaaagtt caccgatgtc 3360 ccgataatgt cctttataga ttccaccccc caccacccca atctgggatc cagtccagga 3420 ttatgtattg cgtttaatca tcatgtctct agtttccaca aatgtagaac gttcctcaga 3480 ctttctttgt ctttagtggc actgggagtt ttgatgagtc cagttgtttt gcagactgtc 3540 cctcaatttg ggattgtctc attagattag atgcagggat gcatctttgc aggaatgtct 3600 taaaagcaat gttattcttc tcagcacatc acaccaggaa gtgcatgatg tcagtttctt 3660 ccatcctcag tgccgtcttc tgcctttcaa ttcactgtcc tcactctgac ttctcttgtt 3720 tgttctagaa ctttgctccc cagctgtctt atggctatga tgagaaatca accggaggaa 3780 tttccgtgcc tggccccatg gtgagccagc agggggagca tggatgacag aagagagaat 3840 gggtatccag aggaggtggg cataggcggc tggtatagac agcttgggag gtccagatca 3900 cctttgggac ctcagagtcc agaaaggatg caggacgact gggtggtccc aacaggcatg 3960 aatgactaca tccacatgct ttcctacaga gggatcacca tgacccccct ttcttctccc 4020 tctatagggt ccctctggtc ctcgtggtct ccctggcccc cctggtgcac ctgtgagtat 4080 ccaggacgtc ttcatatgcc tccttgggct ttggtctttt ggagggaaga ctgggatgag 4140 Página 152 ggcaggagag atgctcagag atctcttggt aagattggag aaggttgaca gggacttgtc 4200 ttctaaccca tctttttcct tcttctcaag ggtccccaag gcttccaagg tccccctggt 4260 gagcctggcg agcctggagc ttcagtaagc actctctata cagattcata ctccttctac 4320 aaacacacag actctcctat agaagaactc ccaggcctgg ggtcttcctt acctcttccc 4380 ttcaatccca gccttcccct tctttttttc ttatccatat tctaaccacc tcttctatct 4440 tttctagggt cccatgggtc cccgaggtcc cccaggtccc cctggaaaga atggagatga 4500 tgtaagtatc cccagcaaga agataccatc tgaccccatg gcctccatgg gttgggtcct 4560 gcaatttcca ctccaccaca tttgggaacg atactcagag gaaggagggc aagtcctctc 4620 tgatgcacgg actgccctgg aacaatgatc ttttcgctta gtgagatgat tccatgtccc 4680 caacaaagtg actgttctcc tcaccccagc caccttagag caatccccaa ccccatccct 4740 ttggggaaat tggtgcgcag atggtgaaat taaaatgctg gtgacagaag tagacagaaa 4800 ttcctttaga ggcactcaga tttcaccaaa cgaaggtttc actgtagatt taaactgagc 4860 tctagattca aagataagat tctgggcccc caaacctgac ctgcaacaat ccaaagaaga 4920 ctgagacctt ctccactttt ccagccccta ggcggtggtg gggaggcaga ggcatgatgg 4980 tcttttctct ccctctcagg gggaagctgg aaaacctggt cgtcctggtg agcgtgggcc 5040 tcctgggcct caggtgagca gggggctgtg gctgaacctg ggcttcactg cacttgggct 5100 tcatttagga gctgggtcca cagtgatgtg ttctaatggc ccttccttgt cttcttcatc 5160 tctctccagg gtgctcgagg attgcccgga acagctggcc tccctggaat gaagggacac 5220 agagtgagtc acctttgagt catttaagct ccccaagtcc ctagcatacc cccatccagt 5280 cccaacctct tccccaaaag atactgagtt gcatcatggt gggtggcagc tacagaagtc 5340 ccaagggaca gagagtggac atccaaaagc acctccctcc atgggaaagc agtcccgatt 5400 aaacgattgg gtgagatcta gagccagttg gggtttagtc tagctcagaa acaaagggat 5460 ggcggtgatg acctcccaag gctctttctc agatctaggt ggatgtcaag gctgttccac 5520 cccctccaca ggttcttacc ttctacctct ttcctgcttt agggtttcag tggtttggat 5580 ggtgccaagg gagatgctgg tcctgctggt cctaaggtaa gaggctgtct gaacatcatg 5640 gtcctccaca tccccagagt cccaccatga atgaatttct cactcattat tctctgatct 5700 acagggtgag cctggcagcc ctggtgaaaa tggagctcct ggtcagatgg tgagtgtgcc 5760 cagttccaga gggcagggat ggggcaggag gcaggggcaa gatggaggcc tgggggaaca 5820 aggctgtctc ccatctcatc tgacttctct tggtttggtt gtcagggccc ccgtggcctg 5880 cctggtgaga gaggtcgccc tggagcccct ggccctgctg taagtactcc tggccccttg 5940 ggggatccct gagctctgga aggggctccc caggaactct agggactggc cagtgctcag 6000 tggacttaac ggggcttccc ctctctcctg cagggtgctc gtggaaatga tggtgctact 6060 ggtgctgccg ggccccctgt gagtgtggcc tgtaggcctc agggcctggg agtggggagg 6120 ggtctcagta tctgctcttg gggctgacaa tgggagcagg ttatgttggt ctgaacccca 6180 ggacttcctc tgtcccaggg tgtgacttgc agctgccatc tcttccttct cgctgacatc 6240 Página 153 tccatttcat tcacagggtc ccaccggccc cgctggtcct cctggcttcc ctggtgctgt 6300 tggtgctaag gtgagacccc ccactctcct ctaagcatga ccctcatggg ccaaggggtt 6360 catgtctccc tgttccccaa accaaaggga cccagagtgg caagagagca gcccgttcac 6420 taacaccttt gtcctgggtt ctccgtctct gatcttagag tcctgatcat tgctctcctg 6480 tccctgtctc cccttcctcc tgccatcccg agaggcaagg ttgggtttcc cagggtggct 6540 tctgatatgt cctttcttct gattcagggt gaagctggtc cccaagggcc ccgaggctct 6600 gaaggtcccc agggtgtgcg tggtgagcct ggcccccctg gccctgctgg tgctgctggc 6660 cctgctgtaa gtgtccccga ctcagtgtcc cctttgccac tttctaacct cagagtcctt 6720 gcctgttgct gacactcctt tctctgtgcc acagggaaac cctggtgctg atggacagcc 6780 tggtgctaaa ggtgccaatg taagtatcct gccaggcttc agtcccactc ctgccgcctg 6840 cagcctgcct gcccctttcc ctctgctcct aggctcacgc cctggctgtc tgcctcccac 6900 agggtgctcc tggtattgct ggtgctcctg gcttccctgg tgcccgaggc ccctctggac 6960 cccagggccc cggcggccct cctggtccca agggtaacag cgtgagtacc aaactctccc 7020 ttctgcccac cccatgcact ggctccagtg cggctctcat ctggggagca ggaagacgca 7080 ggccaactga gcgcccccga ctctcagctc atcctcttct ccccccttgc agggtgaacc 7140 tggtgctcct ggcagcaaag gagacactgg tgctaaggga gagcctgtaa gtctccccgc 7200 catccttctt gcagcccagc ccaccctgcc ctaggagccc cctgagggaa atccagaaag 7260 gaagaggagc ccctagtctt ctgggggagt ccctgccaca cccccaggaa cccctgacac 7320 tggaggccca gcctcagccg gctctgaggc tggcacagga tggcccctca ccacaggccg 7380 cctcctcctc tcggccctct ccagggccct gttggtgttc aaggaccccc tggccctgct 7440 ggagaggaag gaaagcgagg agctcgaggt gaacccggac ccactggcct gcccggaccc 7500 cctggcgagc gtgtaagtgt ccctgcccgc cccctcccgc tccaccctca ttgcctggct 7560 ggtgcctgtg tgtcgcggag ttcactggcc tcctctcctc ctgcagggtg gacctggtag 7620 ccgtggtttc cctggcgcag atggtgttgc tggtcccaag gtaacctctc cttgcggccg 7680 gggggctgac cctgccgctc cctgggcatc ttcttcctct tttggcccgt ggcaaagagc 7740 cacaaacttg agaccctaac tgttcctgtg acttccccca accagggtcc cgctggtgaa 7800 cgtggttctc ctggccctgc tggccccaaa ggatctcctg gtgaagctgg tcgtcccggt 7860 gaagctggtc tgcctggtgc caaggtgagg ccccaggctt tcagcctggc ttggccaggc 7920 cctgaccatc ccgtgtaggg tctgggatga ggcgttctgg atcaggccca agggtctgcc 7980 ctctggagtc ctcccccacc tccatcatgc ttctccccaa gtcccactca tacctctctg 8040 cctccctagg gtctgactgg aagccctggc agccctggtc ctgatggcaa aactggcccc 8100 cctgtaagta tcactccccc tgaaccccct gccattgtcc tgtctgcctc cctgctgtcc 8160 tcactgctgc tttcgtgcct cccatcctta gggtcccgcc ggtcaagatg gtcgccccgg 8220 acccccaggc ccacctggtg cccgtggtca ggctggtgtg atgggattcc ctggacctaa 8280 aggtgctgct gtgagtatta agtgaggatc catgaagagc cagggacaaa cacacctgag 8340 Página 154 acttgaagga gtcctgggct ctgggctcag ctgtgccgct gacctgccgt gtggccactc 8400 actctcactt tctggacctc agcctcccta tctgtaaaat gaaagacttc tcggcggggc 8460 acggtggctc atgcctgtaa tcccagcact ttgggaggcc aaggcgggca gaccatgagg 8520 tcaggagttt gagaccagtc gggccaacat agtgaaacca cgtctctact aaaaatacaa 8580 aagattagct gggtgtggtg gtgtgcacct gtaaccccag ctagtcagga ggctgaggca 8640 ggagaattgc atgaacccgg gaggtggagg ttgcagtgag ctgagatcac gccattgcac 8700 tccagcctgg gcaacagtgc gagattccat ctcaaaaaaa aaaaaaaaga agaaagaaag 8760 aaagaaaaaa tgaaacactt ctccaggctc catgaccact gctctgtcct ggaaataagt 8820 gttgttggtg gccctccacc ccgacacgtg gggataggac aggcctttga tatgataggc 8880 acccccagtc ttggtggatt ctttgaggtc caaaaggaga tagcagagaa gatgaaagcc 8940 ctttgcagtg caggccacag cgggcatcta acagggaaaa ggcagaggag cctggaaggg 9000 catcttggga ggagtgggct cagaaagggc ccagcaagaa gcacctgcag gggcattccc 9060 cgggggccaa acagtctttt gaaaagaaag tcccttaaaa agtcccactc agagtaaatg 9120 agaggcccca ggaggccctg gcttctcact tcagccccct caaccctaac tccctttctc 9180 cacagggaga gcccggcaag gctggagagc gaggtgttcc cggaccccct ggcgctgtcg 9240 taagtatctc ctttccatcc ctacctcctt cccattgctg ccccggcact ttctcctccc 9300 tgcaggaggg gtgctagagg ccacggtcct cagctgctcg gggcctccta accctgagtt 9360 cccctttgct ctctccctgc agggtcctgc tggcaaagat ggagaggctg gagctcaggg 9420 accccctggc cctgctgtga gtgtccctga tggggagatc tggggagcag aaaaggggag 9480 acaccctcag cccctcgtct cctcggcctc cccgtgactg tagtgttctc tctgtgcagg 9540 gtcccgctgg cgagagaggt gaacaaggcc ctgctggctc ccccggattc caggtgaggc 9600 ctcatggctg tcaggatgct gggaggtagg ggtaggaaac acctctttgg tctcttccag 9660 attctaaacc ttccctccct tcttccccca tttcccacct acagggtctc cctggtcctg 9720 ctggtcctcc aggtgaagca ggcaaacctg gtgaacaggt aagagggagc agccggccag 9780 aggggtggga gatgcaggga atccagaggg acaggccccc gctcctagct aatcagacag 9840 ccatcaacta gagggattga ggttagacgc cggaaagaac ttcctcccat gaagggagca 9900 gcacagaggg aagtgggggc tgcatgattg ctagtctggg tgacttcttt taagagctgc 9960 tggaatatgc tgtgactttc cctcaaccct tctattgata aatcttggtc catagtttgg 10020 ggagggggga agcctttgac acatccctag gaggaagaga ggggctgttt gggataatct 10080 caattcagtg ctgagaaggg gttcctctct aatcacggcc agaccccagg aggaaggacc 10140 gtgctttcca gcagagtggc cccaggtggg ttttgctcac tgtctgttcc tctctccctc 10200 cccctcaggg tgttcctgga gaccttggcg cccctggccc ctctggagca agagtaagta 10260 ggcctctctc gctgcatccg tcaaggtgcg tcgtacttgg ccctatctcc agagcagcct 10320 tcacatgccc tgtccttccc ttctagggcg agagaggttt ccctggcgag cgtggtgtgc 10380 aaggtccccc tggtcctgct ggtccccgag gggccaacgg tgctcccggc aacgatggtg 10440 Página 155 ctaaggtgag ggcagcgtgg aaggggctct ggcaagtggc ccagggacca ggtctcaccc 10500 ctcctgcagc aggggatggc gggccatgac caaagccatg gagatagggt gtggggtggg 10560 gggaaaagac cagggcaggg gcccacacac agcctggagt ctgggctgtg agtcttttca 10620 tcttttctca aggcttgtcg ttggccttgg aaacaagcct gggagatacc aagcggggct 10680 tagggctgtg acccactctt ggggccccag gcctcactcc agtcttcttg gttgtcacat 10740 agggtgatgc tggtgcccct ggagctcccg gtagccaggg cgcccctggc cttcagggaa 10800 tgcctggtga acgtggtgca gctggtcttc cagggcctaa gggtgacaga gtaagttcaa 10860 ccttccccct cccctgagcc ctacatggct cccatctctg cctgctttga atctctcagc 10920 atctctcctt ctctctggga tctgtccctc ttctcgctaa tcctcccttc ttcccctttc 10980 ccctctggcc tttttgctga tgaatcctct ccctgtggtc caggcccatc tatccccatg 11040 ggttaccatg gtgatgagag gtgggggcat ctccttggtg gaggctccct tattcatccc 11100 gctacacaag tcaggggcct cttaacctca gttccacctg agtctccagg caggcaccct 11160 ttttcctgaa agaatctttg agtccttggc ccaggtggag gcagggcaga gctgcagagg 11220 gcctctcagg aaacccagac acaagcagaa cactataggt cacctccttg ccccacactg 11280 gaaatctcaa gcttatccat gtctttaggg tgatgctggt cccaaaggtg ctgatggctc 11340 tcctggcaaa gatggcgtcc gtggtctgac tggccccatt ggtcctcctg gccctgctgg 11400 tgcccctggt gacaaggtga ggtggccgcc tccccacctt ctgccctaac acatagcctc 11460 ctcagcaggc ctgggcacgg ttccgtgggg ttgcgttggg agagcaggtc ctgccaaact 11520 gagctgtcaa cctgggaacc tggagggacc agaaggaggg gaggctctcc tggggtcatc 11580 tactaggagt attcagggga ggccctgacc ctgagcctct tgtcccttgc tctcagggtg 11640 aaagtggtcc cagcggccct gctggtccca ctggagctcg tggtgccccc gtaagtacag 11700 aagacctgtt aagaccccat acttggccct tccctccctt cacacagcac ccctggccct 11760 gtctgtgcct tcaccccttg cctctcccct caccgcatcc ccgccttccc tcctgtcagc 11820 gcatctctcc aatctgactc cttttcttct agggagaccg tggtgagcct ggtccccccg 11880 gccctgctgg ctttgctggc ccccctgtga gtaccaagac ccccatcatt tttcatcacc 11940 gactgggacc tgggacctcg agggacggaa tgaggacaaa ggcgtcagcc atcctcaggg 12000 gagaagggtg gagacgggat tgtttcccac ccaagcatct tcctgcctcc attactgctc 12060 ctcccccagg tagtggaaac tcctgcctcc ttccctccat tcaccgccct gcttcctccc 12120 ccagggtgct gacggccaac ctggtgctaa aggcgaacct ggtgatgctg gtgctaaagg 12180 cgatgctggt ccccctggcc ctgccggacc cgctggaccc cctggcccca ttgtgagtgg 12240 cttggccctc tgtgcccacg aggctggtgg gctgggaccc aggacgggtc caggcttgat 12300 gcctctgtgc tctcctacag ggtaatgttg gtgctcctgg agccaaaggt gctcgcggca 12360 gcgctggtcc ccctgtgagt atcacccgcc tctctgttga gcctctcccc tctccccagg 12420 cagcggtggc aggtgagggc agctgggtcg gatgagttgg ctgttctccc tctgactgtt 12480 cctatgttct ctccttccag ggtgctactg gtttccctgg tgctgctggc cgagtcggtc 12540 Página 156 ctcctggccc ctctgtaagt ctctgcagca gagtccactg ctctaggttg ggggtgctgg 12600 gtgggggctg ccagaaggat ggtggggctg actgaggacc caatgatgca ccagagcccc 12660 ctggagtctg acagcccctc ctatcctcat ccagggaaat gctggacccc ctggccctcc 12720 tggtcctgct ggcaaagaag gcggcaaagg tccccgtggt gagactggcc ctgctggacg 12780 tcctggtgaa gttggtcccc ctggtccccc tggccctgct ggcgagaaag gatcccctgg 12840 tgctgatggt cctgctgtaa gtgccagctc agatctctgc agctccggag gtgtgcagag 12900 ctggggaggg gtccctgtgc tgctctctgg cacctcaccc ctgtttgcct cccaaagggt 12960 gctcctggta ctcccgggcc tcaaggtatt gctggacagc gtggtgtggt cggcctgcct 13020 ggtcagagag gagagagagg cttccctggt cttcctggcc cctctgtaag tgcccccctc 13080 accttggggg gccctgagaa aaaccatcac aggacttgga gtggggcgga gccaaggaga 13140 acagatttgg tagagatgac tccagcggac tcaagggtcc tcccagaccc tatctctggc 13200 ctgactcttt cttctccctt agggtgaacc tggcaaacaa ggtccctctg gagcaagtgg 13260 tgaacgtggt ccccctggtc ccatgggccc ccctggattg gctggacccc ctggtgaatc 13320 tggacgtgag gtgagcagtc cccagccccc atgccagtac cctcagcatg gccattgtgg 13380 ccttgcctaa gccctcttcc ccggctgact ctcacttctc tctctctctc tctgcagggg 13440 gctcctggtg ccgaaggttc ccctggacga gacggttctc ctggcgccaa ggtaagatgg 13500 caacactcca tgaccacagc cttgtctgct gcttccctgc cccatcctgg cccttcaccc 13560 ggggctgacc catattcccc tgctctcccc gccagggtga ccgtggtgag accggccccg 13620 ctggaccccc tggtgctcct ggtgctcctg gtgcccctgg ccccgttggc cctgctggca 13680 agagtggtga tcgtggtgag actgtaagta gctgggctcc agttccctgt acctggtcag 13740 gccagggact cttcaggcct ccttagaggc ctggggatgg gtgtcggact tcacccaggc 13800 agggggagga aaggagatcc tgcaagatgt cagggcctta atccaaaaaa ctgagttaaa 13860 gctcagcccc aagtcccctc tcccagacag gaccgcctct cccatgagtt ggccccagct 13920 cccgtgaaga ttgcagtggg gaggtttccc tgggagttgg gagagatggc cacagtggga 13980 agcagctgag gagagagaga tccagcagag gggaggcctc atcctgcagc cccagcctca 14040 gccttccctg gccaagagct catgctttcc ttgctctccc cagggtcctg ctggtcccac 14100 cggtcctgtc ggccctgttg gcgcccgtgg ccccgccgta agtaccctgc tgtgtccccc 14160 atgcctttag aactctacag atgcagacag tgccccactc gatgccaatg gaacttccgc 14220 ctgacagttt gtccctttct ctcttctagg gaccccaagg cccccgtggt gacaagggtg 14280 agacaggcga acagggcgac agaggcataa agggtcaccg tggcttctct ggcctccagg 14340 gtccccctgg ccctcctgta agtatgctca gcccctcccc agtccccatg ctgtgctgtg 14400 ggataggagg gggagcttcg cctcagtttc cccctctgga tagtcattct ttcccctccc 14460 tagtggggac tggggtctga agatttgtgg gcatgtccaa gtagcttctg agagggtgag 14520 gggtacacag agagggatta tgggagaggt ctctgcctat ggacaccctc gggctagatt 14580 tccagaataa tgaaggggca tgggttgccc acactgccct tgtctctcca gccaggccct 14640 Página 157 caggctacat ttgacgctca ctgggcctga actgcctttt ttatctgtcc ttcagggctc 14700 tcctggtgaa caaggtccct ctggagcctc tggtcctgct ggtccccgag taagtcatgc 14760 cttctctctc ctcttcctga gccccaagcc caggctcacc tcggggaccc ttgccaggga 14820 cccaggcacc ctttgcctct ctggagaagg gttcagggac agggagtggg caaagagagg 14880 aagaatcctg aacaaacaat ctgatctagc tttggcctct ctgctcccca atccgtcctc 14940 ccctggctca gcggctggga ggagctatgg catgtcctat ggaaagaggc tgaggctggc 15000 tctatgagcc gtggggccag agccagcagg gagggtggtg ggcctctcct ccagagctgg 15060 ggttgttcgg gcttctggca gcctttctca aaccatttcc cccactccag ggtccccctg 15120 gctctgctgg tgctcctggc aaagatggac tcaacggtct ccctggcccc attgggcccc 15180 ctggtcctcg cggtcgcact ggtgatgctg gtcctgttgt atgtagcccc tcatcccctc 15240 tgctcatggc cctccagccc ccaaagcact tggatgccgg taatccccac tctcttccct 15300 ctctgtgcag ggtccccccg gccctcctgg acctcctggt ccccctggtc ctcccagcgc 15360 tggtttcgac ttcagcttcc tgccccagcc acctcaagag aaggctcacg atggtggccg 15420 ctactaccgg gctgatgatg ccaatgtggt tcgtgaccgt gacctcgagg tggacaccac 15480 cctcaagagc ctgagccagc agatcgagaa catccggagc ccagagggca gccgcaagaa 15540 ccccgcccgc acctgccgtg acctcaagat gtgccactct gactggaaga gtggtgaggg 15600 cctgccctag cctctccctc cctcctactc ctgccatgcc agggtcccca tgcccatatg 15660 tgcccctacc atatggtgct ggctgctccc tttccctgac tccatcttgc cctgccctac 15720 cacaggagag tactggattg accccaacca aggctgcaac ctggatgcca tcaaagtctt 15780 ctgcaacatg gagactggtg agacctgcgt gtaccccact cagcccagtg tggcccagaa 15840 gaactggtac atcagcaaga accccaagga caagaggcat gtctggttcg gcgagagcat 15900 gaccgatgga ttccaggtgc gtgagctgga cctcagagcc agtgttagga gatgggctag 15960 cccagtgctc agaagggaca tgaagtcctg gagtaggtct ctgctaaggg tgatggacag 16020 agctgggctg ggaggcaggg gtctcaggtc cctgatagtg gttcagacac aggctgccga 16080 tgggcaggtg gtgcctcctc tcgatataac ggtgcattgg gcagctctct gaggaccctg 16140 gacagggagg ccaggcagga ctagaggttc ccgcatagcg gctcactctt ccctctctcc 16200 cctcccctgc agttcgagta tggcggccag ggctccgacc ctgccgatgt ggccatccag 16260 ctgaccttcc tgcgcctgat gtccaccgag gcctcccaga acatcaccta ccactgcaag 16320 aacagcgtgg cctacatgga ccagcagact ggcaacctca agaaggccct gctcctccag 16380 ggctccaacg agatcgagat ccgcgccgag ggcaacagcc gcttcaccta cagcgtcact 16440 gtcgatggct gcacggtgag tgcccagaat ccccaggcag ggccccacct ctccggcctt 16500 gggctttttg gccaggccat agtgccctct ctccatcact cccacgtggt aatgccccct 16560 cccgttgtct ccgccccacc ccagagtcac accggagcct ggggcaagac agtgattgaa 16620 tacaaaacca ccaagacctc ccgcctgccc atcatcgatg tggccccctt ggacgttggt 16680 gccccagacc aggaattcgg cttcgacgtt ggccctgtct gcttcctgta aactccctcc 16740 Página 158 atcccaacct ggctccctcc cacccaacca actttccccc caacccggaa acagacaagc 16800 aacccaaact gaaccccctc aaaagccaaa aaatgggaga caatttcaca tggactttgg 16860 aaaatatttt tttcctttgc attcatctct caaacttagt ttttatcttt gaccaaccga 16920 acatgaccaa aaaccaaaag tgcattcaac cttaccaaaa aaaaaaaaaa aaaaagaata 16980 aataaataac tttttaaaaa aggaagcttg gtccacttgc ttgaagaccc atgcgggggt 17040 aagtcccttt ctgcccgttg ggcttatgaa accccaatgc tgccctttct gctcctttct 17100 ccacaccccc cttggggcct cccctccact ccttcccaaa tctgtctccc cagaagacac 17160 aggaaacaat gtattgtctg cccagcaatc aaaggcaatg ctcaaacacc caagtggccc 17220 ccaccctcag cccgctcctg cccgcccagc acccccaggc cctgggggac ctggggttct 17280 cagactgcca aagaagcctt gccatctggc gctcccatgg ctcttgcaac atctcccctt 17340 cgtttttgag ggggtcatgc cgggggagcc accagcccct cactgggttc ggaggagagt 17400 caggaagggc cacgacaaag cagaaacatc ggatttgggg aacgcgtgtc aatcccttgt 17460 gccgcagggc tgggcgggag agactgttct gttccttgtg taactgtgtt gctgaaagac 17520 tacctcgttc ttgtcttgat gtgtcaccgg ggcaactgcc tgggggcggg gatgggggca 17580 gggtggaagc ggctccccat tttataccaa aggtgctaca tctatgtgat gggtggggtg 17640 gggagggaat cactggtgct atagaaattg agatgccccc ccaggccagc aaatgttcct 17700 ttttgttcaa agtctatttt tattccttga tatttttctt tttttttttt tttttttgtg 17760 gatggggact tgtgaatttt tctaaaggtg ctatttaaca tgggaggaga gcgtgtgcgg 17820 ctccagccca gcccgctgct cactttccac cctctctcca cctgcctctg gcttctcagg 17880 cctctgctct ccgacctctc tcctctgaaa ccctcctcca cagctgcagc ccatcctccc 17940 ggctccctcc tagtctgtcc tgcgtcctct gtccccgggt ttcagagaca acttcccaaa 18000 gcacaaagca gtttttcccc ctaggggtgg gaggaagcaa aagactctgt acctattttg 18060 tatgtgtata ataatttgag atgtttttaa ttattttgat tgctggaata aagcatgtgg 18120 aaatgaccca aacataatcc gcagtggcct cctaatttcc ttctttggag ttgggggagg 18180 ggtagacatg gggaaggggc tttggggtga tgggcttgcc ttccattcct gccctttccc 18240 tccccactat tctcttctag atccctccat aaccccactc ccctttctct cacccttctt 18300 ataccgcaaa cctttctact tcctctttca ttttctattc ttgcaatttc cttgcacctt 18360 ttccaaatcc tcttctcccc tgcaatacca tacaggcaat ccacgtgcac aacacacaca 18420 cacactcttc acatctgggg ttgtccaaac ctcataccca ctccccttca agcccatcca 18480 ctctccaccc cctggatgcc ctgcacttgg tggcggtggg atgctcatgg atactgggag 18540 ggtgagggga gtggaacccg tgaggaggac ctgggggcct ctccttgaac tgacatgaag 18600 ggtcatctgg cctctgctcc cttctcaccc acgctgacct cctgccgaag gagcaacgca 18660 acaggagagg ggtctgctga gcctggcgag ggtctgggag ggaccaggag gaaggcgtgc 18720 tccctgctcg ctgtcctggc cctgggggag tgagggagac agacacctgg gagagctgtg 18780 gggaaggcac tcgcaccgtg ctcttgggaa ggaaggagac ctggccctgc tcaccacgga 18840 Página 159 ctgggtgcct cgacctcctg aatccccaga acacaacccc cctgggctgg ggtggtctgg 18900 ggaaccatcg tgcccccgcc tcccgcctac tcctttttaa gctttttctt tctttctttc 18960 ttttttttct taaattcttg cttcctcttc ccccctcttc tccgtccctt ctctttccct 19020 tcaccttctg cctgctcctt cccagaggcc ctgagaaggc gaggcccgga gggaaggtga 19080 ctgttcggct cccccatctc aggtaagggg gacagcgagt gtggtcagcg ggggacagag 19140 aatccagggc gtcagaagtc cagagagaac caggcacccg gagccaggga gacagcgaga 19200 cgacagctgg tcacctctct cacctcatct caggtctaaa cccaaaaaga acaaaaagcc 19260 cgcactcctc cctaaggtct ccagagagat ggacaagtct gtagatacca tccatcagca 19320 atactaatat cgtgatgtca ttaagtattc atggccgttc attatggcct tcaataattc 19380 atcattagca cttctaccac acttaggaca gtgtagaaag ggaatcagtg tagagaggat 19440 aagaatgatg gcatataaat gaaggcttat tcatatgcaa attacccaaa gttgtgtgat 19500 gcctatccat ctctctttct ctcttttttt tgagacagag tctc 19544 <210> 13 <211> 24514 <212> DNA <213> Homo sapiens <400> 13 ctatattgtg agcaactttg tcttcccacg gtacaaactg aaatatcttt ggcaaatacg 60 tatccgacta tactgtgaag aaatattgac gtgaaaaaag aacgcggaga tctgataaag 120 caacaattca gctcacggcg aggtcctctg caggaggcgg ttggtgggaa gaggcgagtg 180 agcctgcccg tgcgtcccgc atggagacgt ctggattgga aactaccgaa agatgtttca 240 aggaactctc cctgggtgac acgctggttt tcagacgttt gattcagctg ctgcagtttc 300 ctcctccctg acacgggaac tgaactgcag gccgcggcga gccagccagg gaaaccgcct 360 tctccctggg ctcggagctg ctgccggttc tggagggaga gaccccagca aggaggtggt 420 gactcatggg ccgctcctcc ccgccccgcc ccgcccctcc cctcccgccc cgcccctccc 480 ctcccgcccc tcccctctcc tcccgcccct cccctcccct cccctctcct cccgccccgc 540 ccctcccctc ccctcccgcc cctcccctcc cctcccgccc ctctcgcccc gcccctcccc 600 tccttgccct ccgctctcac tctggctggg agcagaaggc agcctcggtc tctgggcggc 660 ggcggcggcc cactctgccc tggccgcgct gtgtggtgac cgcaggcccc agacatgagg 720 gcggcccgtg ctctgctgcc cctgctgctg caggcctgct ggacagccgc gcaggatgag 780 ccggagaccc cgagggccgt ggccttccag ggtgagtggt ggcttggggt gcaggctcca 840 gaccccccgc tctttgctgc cggccagggc cagatgcgcg gggtcccctc ccacgcgtgg 900 aactgcagac tgggggcctg gagcccctga accccactcc ccgctcgggg cggctgcagc 960 gcccagctct gccccaccgg gccttggccg gggcccctag aggctcagca ttcagcattc 1020 tcagcggggc cggaccgcag gcagctcggg aggggctccc tggcgagggg gagctggtgc 1080 ggggctgtct cggcgccccg tgaatccgtt tgacccctca cctggcagtg agtccagacg 1140 Página 160

P201430887 ES 2 553 786 A1 09-06-2014 cacggccccc ccgacccccg ttctagaaga agtcgtgcgc tgctggttct gaatccagcg 1200   agaaaccttc ccgtgaggtc tcacttgtcc ggtcccgtgc cggggacgcc ctgcccttcg 1260 ggggaggttg tgaaggtttc tgactcccct cgaggcacag gagcggtttg gggtctctca 1320 ctccaccccc tccccaccgt ccccaccgag ggacgtcctg ctgccttttc ccgggagagc 1380 ctctccgggc ccggggctct gtgctgcagg cgctgggctg gccgggaggg caggcccagc 1440 agagactcgg ggaatggggc gagagcttga aggcccctct cctccatctt cggccagact 1500 gccccgtgga cctgttcttt gtgctggaca cctctgagag cgtggccctg aggctgaagc 1560 cctacggggc cctcgtggac aaagtcaagt ccttcaccaa gcgcttcatc gacaacctga 1620 gggacaggta ggagggacgc cccgtgacct tcctcctgtg cttctgggcc tcttggaggg 1680 aggggtgggg gcccagggga acacgggtgc gacggcctca acctcctaag gttgggcgag 1740 cgttgccctg accggggccc ctcccggcgc cctccagagt gaggccgggg ccctttccgg 1800 cgccctccag agtgagctgg tctgagcctc tcccagcgcc ttccagagtg agctggtttg 1860 agaccctgct cgcgggggtg gcacctgttc agcagggccg aggtgacagt gaggctgaga 1920 tgtagggaag agaggctccc gcaggctgac cgagagggct cagcgcactg gcccagacac 1980 gcagtcctgc ctggtgcgcg ggagcccctc actaaccacc tggaccctgg tttgttccgt 2040 gggcagtgag agcctctacc tgggtcctgg atcccacgtt ctgaaggtcc ccgactcggg 2100 agccaggagg ggtgtcgctc tgcagcccca gggcccccag gcttggttct gggcttggga 2160 cacggcaccc tctgctccac gttcctccat ctgtgcgtgt ggctgaggac agaccggggg 2220 gagaggggag tcggtcctgt gggtgcacag ggccgctgag gggggggcat gtagaacggg 2280 gctcccccac tgagacgggt cctggcagtg gggacacagc ttagccggcg taggaacccc 2340 cgtcctcctt gaccctgctg actggccgct gggccggagc ctcccgccac cagaaggggc 2400 acagtcagag gctgccggta acagcagggt ggaccttcca gcccacaccg tgcccagcag 2460 gagccattgg taccaggaac cctgagctta gtggacatgg ccaggcccgt gcggcagtgt 2520 ttgggggggg gtctggctgt ggatggcacc ggggaggggc ggccgcgtgg cccagcgtcc 2580 cccgagtcgc ccttgttgcc tttactcagt ctccccatga ctcagtttcc cacctgtgaa 2640 atggggcgga gtcatcccca tgtcgctgcc actggattcc tgcaggcgcc gtggtcactc 2700 tgctgaatgg atgggagggt gggtggggca gaggtgggcc caccccaggc tggggcagag 2760 cagacccctg agagcctcag gctcaggtgc tcagagggca gcgagggggc tgctcagatc 2820 cccggggtgc ctccttcccc cactgtcatg ctgccccact gcaggcccaa ggaccccacc 2880 ccagcagggc cacacactca gggctcctgg tctgagggcc tgagggatcg gggcgcaggt 2940 cgcttgctgg ccacacccgc ctgcacagcc ttccaggagg gccggcctca gggccacagg 3000 gcaagtccag ctgtgtgtca gccacggcca gggtggggca gcctgtccat ctgggtgacg 3060 tcgcgccctg ggacgggtag cgatggcgcc aggggccgcc cgcctcacgc ccgccgtgcc 3120 tgttcctggc aggtactacc gctgtgaccg aaacctggtg tggaacgcag gcgcgctgca 3180 ctacagtgac gaggtggaga tcatccaagg cctcacgcgc atgcctggcg gccgcgacgc 3240 Página 161

P201430887 ES 2 553 786 A1 09-06-2014 actcaaaagc agcgtggacg cggtcaagta ctttgggaag ggcacctaca ccgactgcgc 3300   tatcaagaag gggctggagc agctcctcgt ggggtgagtg gcccccagcc tcctgcccac 3360 gccagttctc acgcgtggta cccagcctgg gctggggttg gcctggggtc cctgtgcggc 3420 ttcagctgca gcctccctgt tctcttggag gctgcacggc ctccctgacc cactttgtgg 3480 gcaggaaaga gacggagaca gacagagaca gagagaaaca gaaacaggga gaaacagaca 3540 cagagagaga cagagacaga gagagataga gacagagaca gagagagaca gagacaaaga 3600 gtgacagagg gaccaagaca ggcagacaga gacaaacaga gacagagaca gagacacaga 3660 gagagacaca gagagacaga gacgggaaca gagacaggca gacagagaca gagagagaca 3720 gagacagaaa cagagacaga gggacagaga caggcagaga gagacagaga gacagagaca 3780 gagacagaca aacagagaca gagagacaga aacagggaca gagacagaaa gagagagaga 3840 cagagggaaa cagagagaga cagagacaga tagaaaaaga cagaggcaga gagaagcaga 3900 gacagagaaa caaagacagt cagagacaga cagagacaga gacagaaaca gagacagaga 3960 gacagagaca gaggggcaga gacaggcaga cagagagaca gagacagaga cagcgaaaca 4020 gagacagaaa catacagaga cagagagaca gagagaagca gagacagaca gaggcagaga 4080 gacagagaga agcagagaca gggacagaga cagagacaga aatagagaga tagagacaga 4140 gggacagaga cagagagata gagacagaga gggagacaga gagatagaag cagagagaga 4200 gagacaaaga cagaggcaga gagacagaga gagaagcaca gacagagaca gacagagaga 4260 cagggacaga cagagacaga gagaccggaa acagaggcag agagactgag agactgagag 4320 agacggggtg gttttcccca cagcatcaac accaagcagg gctaggatca ctgaaacaga 4380 ctcatcagac ccgaagcatg cgctttctcg gggtttttct ggactgaggg gtttcctctc 4440 atcccagtgt ccagctgtgg ggacgcaggg gccgcaagcc ccggagtgtc cagaggggaa 4500 cgtggcctcc ccacacccag cccttcacga ggcctcagga tcccagtggg ggtacccgag 4560 gctgccctgt ccagccaggc ggtgcggggg gtttggggag agcctctccc cgaggtcggt 4620 ctcagagggc cacatggccg gtgtgggccg gacattccct ttccaatggt tgtgcccact 4680 tccctccaga gttggtgcca agctgggacc tgggggactt ggagtctcag gaagtcgtcc 4740 gctgtctgca gggggtgcat gggggatgtg gccacacacg tcagagtgcg gccccctgtg 4800 gaagccacag acagacacga ctcccctaaa tgagctcgcc cttctggccg agatgctcag 4860 cgtccccagc aggctgcccg actgccctgc gatactgccc tccttcctgc tgctcccact 4920 ttccctttcg gggggttgga tttggggcat tcagggatcg ccctgttgtt tgctcatcac 4980 acccatttcc tgcaagagcc acggtgaccg agcagccttg agttgaggca gcttgtgggt 5040 agacgcggcg ggcatctcgg aggggcacgc tccctgccac cctcagcctc cactcactgg 5100 tcaggggctt tgcgccccag ggcaccccag gaaccgagcc tcctttgggg tcatgggtgc 5160 ctctcctggg agggcgtgga ttttccaaag cagtttagag aaatgagacc cacaggcgtt 5220 atttcccatg gtgaggttct tttcagtaac ccccaccgta tagccaggat cagcaaagag 5280 aggcggctcc tcccggtgag acagggacca gcacctcccg gacaggcttg ggtctccctc 5340 Página 162

P201430887 ES 2 553 786 A1 09-06-2014 cagttccccc acctagtctc gaggtctcac gctgccctct cctgtccagg ggctcccacc 5400   tgaaggagaa taagtacctg attgtggtga ccgacgggca ccccctggag ggctacaagg 5460 aaccctgtgg ggggctggag gatgctgtga acgaggccaa gcacctgggc gtcaaagtct 5520 tctcggtggc catcacaccc gaccacctgg taggcaccgg ccccccccgg cagatgcccc 5580 caaccacagg gagtggcggc tgcaaggccc ccggcagctg ggaccgtctt ttggtcctcg 5640 ggagggtgtg ggttctccag ccggccaccc ttgcccctga gaggccagcc cctcctgctg 5700 aggagcctgg agcgccccag cccagcctcc cctctggccc tgtgggaagc ggccccggcc 5760 gtcaggggtc ccagccctgc tcagcccacc ctgaacactg cccccaggag ccgcgtctga 5820 gcatcatcgc cacggaccac acgtaccggc gcaacttcac ggcggctgac tggggccaga 5880 gccgcgacgc agaggaggcc atcagccaga ccatcgacac catcgtggac atgatcgtga 5940 ggcccctgcc caggagacgg ggaggcccgc ggcggccgca ggtggaaagt aattctgcgt 6000 ttccatttct ctttccagaa aaataacgtg gagcaagtgg taagagccct ccccaccacc 6060 cccagccgtg agtctgcaca cgtccaccca cacgtccacc tgtgtgttca ggacgcatgt 6120 ccctatgcat atccgcccat gtgcccggga cacatgtccc ctgcgtgtct gcccgtgtgc 6180 ccgggatgtg tgtccccctg cgtgtccacc tgtgtgtctg cccatgtgcc tgggacatgt 6240 gtccgcctgt gcgtccatcc gtgtgtccgt ctgcccatgt gcctgggtcg catgtcaccc 6300 tgtgtcccag ccgtatgtcc gtggctttcc cactgactcg tctccatgct ttccccccac 6360 agtgctgctc cttcgaatgc caggtgagtg tgccccccga cccctgaccc cgcgccctgc 6420 accctgggaa cctgagtctg gggtcctggc tgaccgtccc ctctgccttg cagcctgcaa 6480 gaggacctcc ggggctccgg ggcgaccccg gctttgaggt gagtggtgac tcctgctcct 6540 cccatgtgtt gtggggcctg ggagtggggg tggcaggacc aaagcctcct gggcacccaa 6600 gtccaccatg aggatccaga ggggacggcg ggggtccaga tggaggggac ggcgggggtc 6660 cagatggagg ggacggcggg agtccagatg gaggggatgg cggggtccag atggagggga 6720 cggcggggtc cagatggagg ggacggcggg gtccagatgg aggggatggc ggggtccaga 6780 tggaggggac ggcggggtcc agatggaggg gacggcgggg tccagatgga ggggacgtcg 6840 gggctccaga tggaggggac ggcgggagtc cagatggagg ggacggcggg gtccagatgg 6900 aggggacggc ggggtccaga tggaggggac ggcggggtcc agatggaggg gacgtcgggg 6960 ctccagatgg aggggacggc gggagtccag atggagggga cggcgtggtc cagatggagg 7020 ggacggcggg gtccagatgg aggggacgtc ggggctccag atggagggga cggcgggggt 7080 ccagatggag gggacggcgg ggtccagatg gaggggacgg cggggtccag atggagggga 7140 cggcggggtc cagatggagg ggacggcggg gtccagatgg aggggacggc ggggtccaga 7200 tggaggggac ggcgggagtc cagatggagg ggacggcgtg gtccagatgg aggggacggc 7260 ggggtccaga tggaggggac gtcggggctc cagatggagg ggacggcggg gtccagatgg 7320 aggggatgtc ggggtccaga tggaagggac ggcggggtcc agcaggcagg ctccggccgt 7380 gcagggtgtg gactgtcccg ggggcgctgg gggcttctga gggtgtctct gtccgccctg 7440 Página 163

P201430887 ES 2 553 786 A1 09-06-2014 ccctcagccg cactctgttc agaaggacct ttctggaggt aggagggtga gaatgtgggt 7500   cccctgcttc tgtgtggctc acataggatg accttaaacg ttagaattag ctgctgataa 7560 ttaaaacttg ccatgaggct gctcatggac ctcagatttc tggcttctcc taaaaaccat 7620 caaacccagc agctgtgggc ccgagtccca tggccatttc ctgggggtcg agctgtgacc 7680 ctggggggct tctgtgctgc acgtccctcc cacctgtgcc tgggggtcag caaagccgag 7740 cagacaggaa cgaaggcagg gagtgggggg agctggcgtg cgggttggag ctcccagacc 7800 caggctgacc agatgtgatg gggaaggtgc tttaaagccc ttgatccctg aaggctggat 7860 gaagcgtctt tttaaaaacc tgtttcgtga gccagctttt tagaaagaaa cggggctgcc 7920 ccaaccttga cctgttttgt gttccaggga gaacgaggca agccggggct cccaggagag 7980 aagggagaag ccggagatcc tgtgagtgcc tgactgtggg gtgggggccc taagaagctg 8040 gaggcgggga acgactaggc ctcggaaact tccggaagag tggctgggtt ctgagtgcca 8100 aagtcacact gcctgttcct tgtgggtggg agcagacctg gaggggccac agcccagcca 8160 tccttccaca cagcccccca ggcagcccgt aagcccccct gccagggagg ggctgggtgg 8220 ggaggtggcc cagggtgctc aggccggcac cgtccggggc ccctgccgtg gctccttggc 8280 ccaaatccta tccatagact tccctccccc agctccacct tggagggcct cggcaccatg 8340 ggccccgtgc agcagggccc ctctctcggc ctgaccaggc ctgggctgga gggaggggtg 8400 tggggctggg tgggactggc ccctgcccct gctcctccgg gggtgtctca ccatctcctc 8460 ctgtgttcca gggaagaccc ggggacctcg gacctgttgg gtaccaggga atgaaggtac 8520 gtgccccccc tttcctggcc cgagcccggt ggtgccctca gccttgcaca gcactaacaa 8580 gccttcctct tcctcttctt ccgctgggtg tgtagggaga aaaagggagc cgtggggaga 8640 aggtgagtga ggctcgacct cggagctggt ctctccaggc gcagatgtgc catcctggac 8700 gagggtgtcc ccggggatga ggacagtgtc cctgacagga gaccacgtgt cctgcagacc 8760 cgctccaccg cccctcgccg tcccctccat ctggaaggac aaggacagcc acccaggcac 8820 ccagcaaagg cgcctgtgtc actttcaccc caccccagag caggggtccc ccgggcggtt 8880 accctctgcg gagccggggg tcccccgggc ggttaccctc tgcggagccg ggggtccccc 8940 gggcggttac cctctgcaga gcggcccctc cccatcactg tcagtcccca tgattctcag 9000 cagtgatgtt gtcccctcgg gttgggggca cccaagcccc tgcctcgcgt gggcctaagc 9060 caggcttgcc ctgccctccc caccccaaat accccctcac acccgcttcc tgtctccgca 9120 gggctccagg ggacccaagg gctacaaggt gagcgtgggc tgctgggagg ggggagttct 9180 gcccccacgg cagcatgtct gacctgcatc tgactcctgc cttcgttttc ccgcctcaca 9240 gggagagaag ggcaagcgtg gcatcgacgg ggtggacggc gtgaaggtga ctggggggag 9300 ataggatgga cggggaggga cgaggaggaa tggggcgaga tggggaggga cggagtggac 9360 ggcgtgaagg tgacccgggg agggatgggg tggacagtgt gaaggtgacc aggggaagga 9420 cggggaggga cggggaggga tggggtgagg tgatcccggc aggagggaca gggaggagtg 9480 gggtggacgg tgtgaaggtg accccagggg ggtgtctgct aggcagggct ttccagggag 9540 Página 164

P201430887 ES 2 553 786 A1 09-06-2014 ggtgtggagg gcatggaggg caccaagtct gacagttgat tggcctcagt ttacccactt 9600   ggccgtcaga ttttctagtt ttcttcctct ttccaggggg agatggggta cccaggcctg 9660 ccaggctgca agggctcgcc cgggtttgac gtaagtcact tcctctcact gatactttaa 9720 aactagcgct gtcagcagca cctcgtgtgg accgttttga cttctgtctg ggcggtctgg 9780 ggctgctgcc agaggccgcg gtggcctctg ccggtggtgt catgctgccc tcttttctcc 9840 agggcattca aggaccccct ggccccaagg gagaccccgg tgcctttgga ctgaaaggag 9900 aaaaggtgag tgacttgcgg cccctggagg accagggcct tcacggttgg ccaagcgctg 9960 aattggaaac ctctcctgga agcaagtcct ggtccgagca tgtcggccac ccgtgcggcc 10020 tcagagggga ggagctggtg gaggctggag gcaggcagag gagcagcggg gacagtgccc 10080 accgtgggga cagtggccgt ggcgctcccg cccagagcct tccctgcagc ccgagggcct 10140 tcaggcctcc gccattctgt cccccgcacc tgccgctcgc tcggcacaga tgggacccca 10200 ccgcgtcact cctagcctgc gagccgcagc ccagaatggc tctcagaact gagaatgggc 10260 tgggtggcac tgagggtggc gagtgggcgg gagggtggtg agcgggggcg ggaggagggt 10320 ggtgagcggg tgggagggcg agtgggcagc gggagggcgg gagcacgagg cgggagaagg 10380 agctttttcg tctgacagct gagtctgccg ttgctggtgt tttctctgga gtttctttgt 10440 tgaagctgaa gtgttgggga agacaaaggc gaatgctgac cccaccccaa acattcccag 10500 acgagctcct agaacccagc agacggtttc caaatctcat cttcaagttc ccagattacc 10560 ctccaggccc tagatttgag tttgccaatt tgccagcctg gcaaagctgt gccttctcta 10620 atgggaacca aatcctgccc cttagacaag atggcccttg gctgggcctc acagggaaca 10680 aggttggagc attccaggag gtctttgtgc agggttgtgg atggctgagg gtgctggggg 10740 gtctgggctc agacagtgtt ggtcagaggg agtggcctga agtatgggtg agaggccctg 10800 gatgtggcct ctgatggctg cacccctggt gcacacccct gccagcgtgt gtgactcccc 10860 cggtcttccc cagggcgagc ctggagctga cggggaggcg gggagaccag ggagctcggg 10920 accatctgga gacgaggtga ggagcttcac agcccccaca catgccaggt atgggcccag 10980 ggagggtcaa ggagatggag cgaccattca acccttgttc cccacagggc cagccgggag 11040 agcctgggcc ccccggagag aaaggagagg cgggcgacga ggtgagtgag ggctcctgac 11100 accttcctgg ggaagtgcat ggcctcagct tctgatcctc tttgctcggg gtctactcca 11160 cgtccctgag accaaatgca gtgtgtccac cagactaacg ccggcgtctg tttctcttca 11220 tcccagggga acccaggacc tgacggtgcc cccggggagc gggtgagtgg ggcaggggca 11280 gcctgcgctg ttggcctcac catgtagctg tggacgtggc ctctgcggcc cagtctggcc 11340 ctcccagcac tgagagccat ggcctcctgc ccaagacaaa tgggtttctt cacccacacg 11400 tccaggatgc ctcttcccac agtctcagag cgggtgggac ctggggaacc aggagattcc 11460 ggcctctgca accgtggggc atgcggtgga ggggtggccc ctcccagggg tcctgctggg 11520 ggagtcagtc caggccaggc ctcaagcccc accccagctg ggtgtgagtt ccagcagctg 11580 aggcttctcc cctccatgtc tctccactca gggtggccct ggagagagag gaccacgggg 11640 Página 165

P201430887 ES 2 553 786 A1 09-06-2014 gaccccaggc acgcggggac caagaggaga ccctgtgagt cacagttcct ggagctggga 11700   accaccccag gaaggggcag gcggaggctg gggctgggtc aggcctccag agccacagga 11760 cacatcatga agcccctgtg gcccctcaac gtggccagcc catccccacg ccgtcaggga 11820 gggcagcccc tgaagccggc gcccagccat gtgcctgatg ctgggacctg tttcatgtga 11880 aggcgttgcc cgtggacccg gtgcccactt tcccaccagg cggcttccac gtttctgcat 11940 ccgagcttgg gttcttcttt ggaataattt tccttagtta aaattcccag cgtgaggaag 12000 ttgggtcagt accccagacg ggaagctagg cctgcagggc gcctgcctgg gaaggcttga 12060 catggaaaac tcaccccaga gccgagatgc cggcggcctc agaggccacc ccccaccttc 12120 agctccgtgg accgtgggcc tcgctaggcc accccacagc ccagcctcag ggtgcagaag 12180 cacagggccc ttctctgtcc ctgtgacttg ctgggaaatc tgtgctggat gtggggcggg 12240 gcagctggca gactccgggc gtctcagtcc catccggctc agggagagcc agggcctggc 12300 gggcagagtg aaggggagag aatgccctag tgtgcccagc cgagctgcca ggcctcagag 12360 gcagcgcccc cgggtgcccc cttgtccgag aatcaagaca tgcgactgtc gtgtgctgtg 12420 acagacaggc ggggctccag cagggccaga gagctgagcc ggggccagag tcgccgccac 12480 cgagggattt ggctccccag tggggggtgg gggatttctg acctcctccc tgggagctcc 12540 ccagaagcgc acagcccccg tggaggggtc ggggggacgt caaagcaggg atcgtgtgac 12600 ttagtgactc agactgcctt ctaggcccac tcctctgaga tcaggatatg agactgacag 12660 ccaggcagag cccagaggaa gggccagcca cgcagctcca gcttcccggc gggccacaag 12720 tccatggcta caaacacttg ccgggtccac ggagcttgct ggagaagcag ggatgcacgc 12780 agggacgcct ctggggcccc aggaggagct gccggcctcc tgaatgaaga tagccatagc 12840 cagccacgcc gatggccacg cacgtgggcc gaggaaacgc ttggcgaggc caggaagggg 12900 ctgtgcgggg agggaaggcc ggaacagccc agtgaccacc tggacagcat gctgtggctc 12960 ccagcgtgcc cgggcagcca tcctccccaa ggatggccca gctccacact cacggctcgt 13020 ttctcttcag ggtgaagctg gcccgcaggg tgatcaggga agagaaggcc ccgttggtgt 13080 ccctggagac ccggtaggaa gcgctgtggg gttggggggc gttggccaat ttgggttttg 13140 ggggtagaag tgctccagca gctcacgcac tgggggtctg ttcatttccg tttgagggcc 13200 tctgtgtttc cgtagatctc gggggtgtcc ctgcgtggga gccggctgca gggggtgagg 13260 cgcggcctgg gccgggctgg tgtggattgt tgagagcagg cccagcgccc gggggcctga 13320 cgctgagacg ctcagcccag gtggagaagc gctgtctggg ggcccatccg gggcaagggt 13380 gcctcacagt gaggaagagg tgttggagcc cctgggagac actgggagct tggtcagcat 13440 ctgtttttct gggtcaggag ccaggcatga ctgtggctgg aggtcaactg gggagtgtga 13500 ggctatggag gtttccagaa tcccagggtg tcaggatgaa aatgcacttt catctcattc 13560 taaattccct tctccgagcc tctggaatcg ctgtgcacgc cgcacggctt tctgtctctt 13620 cccccattct gatgactgcc atgatggtgg ctccagtgtg gtgttgcccg caggctgggc 13680 tgggccgttg catcctcccg gagctcacct gccccacggg gacaggaagg cctccacacg 13740 Página 166

P201430887 ES 2 553 786 A1 09-06-2014 gtcacgcccg gagacagcaa gtctgtgctc ccgagcttgt ctgcttctgt ggacaaatcg 13800   accttacggc tccatgtgcg cagctgccca cacaccgagc acaaggccag accctgggca 13860 cggcagctgt ctcagacgtc cagcaagatg gggcctcaga cccagggaga tgggagaggc 13920 cgtcccagtg caagtcacat ttgtatttct gtgcacgagg tgaaatcgtg cttttgtggt 13980 gccaacgggt gttacacagc tgttaaaaat acctgtgtca tagatgagga ccagggcagg 14040 gcttggcagg cggggtctgg gccgttcgtc cacctggtcc tgcgtgccgc tcacggcagg 14100 ggcagaaagg gctcccgaca ccttcctggg gaagtgcacg gcctcagtct ctgatcctct 14160 ttgctctttg agctcccggg gctccagccc tgaggatgat ctgacctccc atgtggtcac 14220 ccaggacagg gccaggtgca gggcacagtg cgtggaagag gccatgcagc cagtggcaga 14280 ttgtggggag gggacggccc agggccacgt tccaggcttg ggaggctgct ccagaccttg 14340 gtagctgaaa gtctcagtgg gaatgagcgt tcagaggcca ggacttgctc ggagaattct 14400 aaccacaccc tgcctgtttt atatgttcag ttttcaaagt aatcaatagc cactataaga 14460 aaaaaacaaa gccactttca aagggttgtg gtaagaggca gtcctgtgag caggccggct 14520 gcagggcctc cagggctgtg gggcaggctg cacaggggct ggtgggtccc atgcctgggg 14580 gtctgggaat agtctctagg ctgctgtcct ggaggaggtt tcccccaacg cctgagacca 14640 gggcaccatg tgacccatga ctcacagttg cctggctgag gcaggcactt gttcacctgg 14700 agcctccctg gggcctttcg gggcccgggg gtgtggatag gtggctttgg agccacattt 14760 gtccatcggg acgttgggct cccagctggc cttccgggct ttccctgctc ccagaacctc 14820 cctgctcagc ccttgccagc cttacccctc ccctccaccc tgcccagcat ggggctctcc 14880 ctgtgtggat gccagaagca gttgggccct cagggctggt cccaggaggt gcccccagtg 14940 aggtgctctg cagaaactgc ccagtctggc ctcctgctgt ctgtggcaca gtctgactgt 15000 gtgtggtgag gtccaggcct tctgcctccc acttacctgg cccagggcac agagacctcc 15060 tttccatcct tcctcctggc ccccttttcg tgttcccaag gcaggatctc agggtaccag 15120 actaacccct gttgaacccc aagtttggtg agcttctgga cctccttgag gcccgtgtgc 15180 aaagtcccca gtcaagtgtg cagtcctgac tgctggggcg ttgaccacga agggtgcagg 15240 agcttcacag ccaggcctgg gtgcttgcac agtcggggta gagagagcaa tacactagat 15300 gcctcctgtc tgcctggtgg aggccacggg gtcaggatgg tgaatgggcc aagtctggta 15360 gtggggaagt tgtaaacatt tgaaccaccg gacaggcctc atcgggaagc atcagcctaa 15420 ccacaggcca gggacaggcg tctgagcagg cacaggccag ggacaggcgt ccgaccaggc 15480 tcatggctgg ggccaggtgg gccaggtggg ccaggtgggc cgggcgatgt gtacacggct 15540 cccttcttgg ctcagctggg cgcgctggga agtgcttggg gtgcctgggc tagactccga 15600 agggcaggga ctcgccgctg gagttgtcca cggagcaggc cctcaaaggt gggagctggg 15660 gccagctctg gaaatagacc cccacagggt cctcatgaga tgtgggggac ccaaggaagt 15720 ccagcaggca gcctcaggtg caggtggggg cagggtggtg tccaggctca gcccacagag 15780 ggtcctgcgg ttgggggtgg gctaagggga ccaggccagg cccaaagggg accatgaggg 15840 Página 167

P201430887 ES 2 553 786 A1 09-06-2014 agggcagtct ggggccactc tgataggaga aggggcaggt ggtctgcggc ctggggacct 15900   gtagcctcac ccctccgtgg ggacctgagg caccagccgg gcactcaccg aagtcatctg 15960 ggacaggctt cacccttccg tgggggcctg aggcaccagc cgggcgccca ccaaagtcat 16020 ctgggagagg cttcacccct ccgtgggggc ctgaggcacc agctgggcgc ccaccgaagg 16080 gcttcaacac ttgtgcccag gcccttcgtg caggcccttc gtcagaccca agagtgggcc 16140 tggctctccc cctgcactga tgggactggg gccagagcct gggggccctg atgcctcttg 16200 gtctgagacc ctcagcttag ggtcagggag ggctcaggct gggtgaggcc tgtggtccaa 16260 cgtgccatat ccatctctct acagggcgag gctggcccta tcggacctaa aggctaccga 16320 ggcgatgagg gtcccccagg gtccgaggtg agtcccactc cccacccaca cccgcccacc 16380 caggggggcc tgaggatcca gaacccactg tctgcccagt gctggccccg tgccctctga 16440 ggactctatg gccctgggtg tcctggctcc cgatgggacc tctcccggcc ccaggagggc 16500 cctgcttccc tccaaggtca ccatgctaag cctgctcccc tcacgcctcc tcttcctcct 16560 cagggtgcca gaggagcccc aggacctgcc ggaccccctg gagacccggg gctgatgggt 16620 gaaagggtga gtgtccaaca gctcgggccc tagggcggag gcctggccgc cagaggccct 16680 gggaagcccc agccccgcac tgtggagctg cctggggtcc ctgaccgggc cgggagtgcc 16740 cgcagcatca ctggctcctg gccacagtcg gcacctgagc cagaggccgc ctcggcaggg 16800 cccctcctgc cccgagatcc gggtcccagg gtccacgggg accagcaggg tggccccagg 16860 ggagggagcc ggcttctggg ctgacggagg ggccctgcgg gtgaggtgct cccgggcctg 16920 tgccagccag tgggtatccc aggccaggcc gattcgcacg gtgacggcta ctctgctccc 16980 ccagggagaa gacggccccg ctggaaatgg caccgagggc ttccccggct tccccgtaag 17040 tgtccggagg ctgagcccac aggaacatgc ccaagctgcc tgcggcgccc tctttagtgg 17100 actgggcact cttgggtggg cgggctggcc ccaggaccgc cggctggccc aggaattcca 17160 tggccgggat tctgtcagct caggcccttc cgctgtgcgc ccctcacagc ctcccctctc 17220 aaatcagaac ccggtatcac tgccctgctt ttccatgaca ggggtatccg ggcaacaggg 17280 gcgctcccgg gataaacgtg agtacgcccc ctcctccatc tggctgtggg cacacaaaca 17340 ttcacagtca cagggacacg cacgtgtgaa cacacatgtg cacacaggct cccgagcaaa 17400 cacacggggt acacaggcac ccacggctgc cccactgtct gtggccacag ccccagttgg 17460 catcggctcc tgcaggccct gcgaggctcc cactgtggtg tggcctgtgg gtctcctcac 17520 ggccctgact gcccggtgac cgatctcccc tcggtgcgca gggcaggccc agccccagag 17580 gccgccccac ggctctctag gccactccgg gacccagttt ctccagccca ggaaatgtgt 17640 gtggtggggg aagggaagag aagagtgcct ctcttatctt tatttttttc cttttaaaat 17700 ttccacttcc taaaaacaaa ataaaaccct tgttaaccaa gtgctctccc gtcactgcag 17760 ggcacgaagg gctaccccgg cctcaagggg gacgagggag aagccgggga ccccggagac 17820 gatgtaagtg tggatgggag gcagggccag ccccaagtcc acctgagcca gagggctggg 17880 cccttgaagg gcagtggacc aggacccgct tggggaggcc tcatgggccc cggctgctgg 17940 Página 168

P201430887 ES 2 553 786 A1 09-06-2014 atgctctgtg gacggggcca gcgcgcagat gcccgggtgg tgcacggtct gttgacacaa 18000   cgctgttccc ttctagaaca acgacattgc accccgagga gtcaaaggag caaaggggta 18060 ccggggtccc gagggccccc aggtgggtgg atgtggctgg gtgaggccac ggtgggctgt 18120 gcctgggacg ccggatgctg gggctgggga atgctggaag aggctgggag agtgggaggc 18180 ggcgggaggg aattttgggg agcacgtcat ctgggaggcc ctgggggtgg gaggtgccgg 18240 tcaccagggc caggtggtgg ccagggcagc agagccgagc ccagggacac agcgggtcct 18300 cagggtgggg cccacctggg atggccgcct ggaccaccag tgtgcgaagc cccagctgcc 18360 ctcacagcac cgtcactgga ggacgagggg ctgggtaggg agggaccggg caggggtggg 18420 cttgatgagg ggcagggccc tgggggtggg ggctgtctca gctcaggaag cacagtgggc 18480 tcctcaccct cagagctcct ctactccgtt tctcggacag ggacccccag gacaccaagg 18540 accgcctggg ccggacgtaa gtggggctct gtgaacattg ctgggggcga ccactgtagc 18600 ttccatccct tggggtgtgg gtcctgtcca tgggtgctcc tgtagacgct gctcacgggg 18660 gggtgggttg tggacaaaga gctggtgcca ggccctaggg acccgtgacg gccatgggag 18720 gacccgtgag gatcataggg ggatgtgtga ggaccataga ggggacatgt gaggatcatg 18780 ggggacatgt gaggatcatg ggggggacgt gtgaggatca tgggaggacg tgaggatcat 18840 ggagggggac atgtgaggat catgggggac ccgtgaggat catgggggac ccgtgtgagg 18900 atcatggggg gggacgtgtg aggatcatgg ggggacctgt acccatgagg accatgaggg 18960 gacccgtgac ggccacgggg agacccatga ctgcgctgtt tctatgacca cgtcaggggt 19020 ccagcccagt agcaggggtg tagtgggcag agccgggcac acctgcaaag aacctcctgc 19080 ccaaaccccg ccctgtgggg gccccaggga gggtgacctg gagatccagc agcccacagt 19140 ccccgctggg aggggctgtc tatggcccca gtaccctcgt ctctccctcc ccaggaatgc 19200 gagattttgg acatcatcat gaaaatgtgc tgtgagtatc tctgagaagc cgtcctcgtt 19260 agggagagca gggccgccag cctggcctgt tccactccta gaagggtgtc tccactgttg 19320 ggggcctggg tctctgggta catccttgag gaggctcctc agccagcccc taccggcctc 19380 caaagccctc ccaggccccc gggtccccgc acaggctgag agtccccggt gcggtgcaga 19440 gctgccacgt ggggagggcg gccggggagg cggggaggcg gggcaggagg ccggggaagg 19500 ggggaggccg gggaaggagg gcggccgggg aggcggggag gctgccccaa gagtaaaagc 19560 ctttctgacg tgcgcaggac gcggccctga ctggtctaac tgactctttc tcttctcctc 19620 agcttgctgt ggtgagaccc aggctctagc tcctgagaga atggatcccg ggggtcgggg 19680 agcgaggcct gggtcccaca catgtcacag gacagcacat ggcactctgg tccccgcccg 19740 cagctccctg cacctgcccg ccccctctgg ggcctgctcc aagccagcag ggttcccggg 19800 tgttgggctg ggccccgccc tctttcaccc ataactgaaa taaccaggag caggcttggg 19860 ggggtccctg ctccatcatt ctggcccaca ggccccaccc tagcctggct gagcaacgcc 19920 agccctgacc agccgccgga cagagcagcc tttacggggc catgggaggg ggtgggcttt 19980 tctggggctg agacgggggg accccaacgt gtcaggtgag gatgtggcag ccaaggaggg 20040 Página 169

P201430887 ES 2 553 786 A1 09-06-2014 gccagggcgg tggaggggag gggccagggc actggagggg aggggcgtgc tctgctgaca 20100   ccgcccccgc ctgcagaatg caagtgcggc cccatcgacc tcctgttcgt gctggacagc 20160 tcagagagca ttggcctgca gaacttcgag attgccaagg acttcgtcgt caaggtcatc 20220 gaccggctga gccgggacga gctggtcaag gtgaggcctc gccccgcccg gctttctcaa 20280 gcccaggtgc accccgaccc tgccggccgc ccctgcccgc gccagacctc agcctcccga 20340 ggccaccgct gcatccctgt gacttcccta ctcatgacaa ggatgccagg cacgcgccag 20400 cccgtccagg cctccagctc cacctggcga ggctggccca ttgtacacag gcgccccaga 20460 tgagggaggg tctccccctc tccttgaagg gcggtagtct ggggtcctga gtgctgggtg 20520 tgggcttgtc cctcgtggac agaacccagg agggcttcat ccaccaagga agattgcttt 20580 gcagggtacc caggtcccgg gggctgtgcc accctctggg cacccggagc caatcgcagg 20640 gtacccaggt cccgggggct gtgccaccct ctgtgcaccc agagccaatc gcaggggacc 20700 caggtcctga ggtcctgggg gccatgccac cctctgggca cccgcagcca atagagtcac 20760 ccttgggaag cttatgcgga cctggggcag cactcgcgtc ctgaccccgg tgccggtccc 20820 acagttcgag ccagggcagt cgtacgcggg tgtggtgcag tacagccaca gccagatgca 20880 ggagcacgtg agcctgcgca gccccagcat ccggaacgtg caggagctca aggagtgagt 20940 gccccacgcg gccaggaccc tcccacccct cgccccgacc gctgttccca cggcaggtcg 21000 gccctgaccc ctgatcccag gtgggctcgg ccccgcggca ggcctggccc caaccggccc 21060 ttcctgccct ttgctatgca gagccatcaa gagcctgcag tggatggcgg gcggcacctt 21120 cacgggggag gccctgcagt acacgcggga ccagctgctg ccgcccagcc cgaacaaccg 21180 catcgccctg gtcatcactg acgggcgctc agacactcag agggacacca caccgctcaa 21240 cgtgctctgc agccccggca tccaggtggg gtggccaccc ccaggctgca cctgccccgc 21300 ctagggcgcc ccgccagcca gggtggcctt gtccccagaa agacgagggc agagcaggct 21360 gcgccacacc gatactgtct gtccccacag gtggtctccg tgggcatcaa agacgtgttt 21420 gacttcatcc caggctcaga ccagctcaat gtcatttctt gccaaggcct ggcaccatcc 21480 cagggccggc ccggcctctc gctggtcaag gagaactatg cagagctgct ggaggatgcc 21540 ttcctgaaga atgtcaccgc ccagatctgc ataggtgcgc atggggccac ccgggcagtc 21600 ccagatctgc gtaggtgcgc gcggggccgc ccgggcagtc ccagatctgc gtaggtgcac 21660 gcggggccgc ccgggcagtc ccagatctgc gtaggtgcac gcggggccgc ccagggccgt 21720 cccagatctg tgtaggtgcg cgcaggcgcc cagggctgtc ccagaggcct cctcccagct 21780 cactgttacc tccaggggca cggccaccct gtaggtgcgc acggggccgc ctggggctgt 21840 cccacaggca tcctcctccc ggctcgctgt gacttccggg ggcacggcca cccctgtgct 21900 cggccgggag gtcctgtgac atctccttgc ggggttatag gtggagcagt gggctcacac 21960 tgcacggctt ttctctttta cagacaagaa gtgtccagat tacacctgcc ccagtgagta 22020 cctcggcggc cgggacacgt ggggaggagg gcaccgtggt tggggcgagg gctctgagag 22080 gacggggctc tgggaggagg gcctggcggt cacgagagta ggtgcatggc tcactccggt 22140 Página 170

P201430887 ES 2 553 786 A1 09-06-2014 ggctgagcac caccgtgccg tgccctctct ggggagctta gacgctctct ggccggccca 22200   ctgcggctgc atcaccaggg cctcatgcta acggctgccc accccgcccc gcagtcacgt 22260 tctcctcccc ggctgacatc accatcctgc tggacggctc cgccagcgtg ggcagccaca 22320 actttgacac caccaagcgc ttcgccaagc gcctggccga gcgcttcctc acagcgggca 22380 ggacggaccc cgcccacgac gtgcgggtgg cggtggtgca gtacagcggc acgggccagc 22440 agcgcccaga gcgggcgtcg ctgcagttcc tgcagaacta cacggccctg gccagtgccg 22500 tcgatgccat ggactttatc aacgacgcca ccgacgtcaa cgatgccctg ggctatgtga 22560 cccgcttcta ccgcgaggcc tcgtccggcg ctgccaagaa gaggctgctg ctcttctcag 22620 atggcaactc gcagggcgcc acgcccgctg ccatcgagaa ggccgtgcag gaagcccagc 22680 gggcaggcat cgagatcttc gtggtggtcg tgggccgcca ggtgaatgag ccccacatcc 22740 gcgtcctggt caccggcaag acggccgagt acgacgtggc ctacggcgag agccacctgt 22800 tccgtgtccc cagctaccag gccctgctcc gcggtgtctt ccaccagaca gtctccagga 22860 aggtggcgct gggctagccc accctgcacg ccggcaccaa accctgtcct cccacccctc 22920 cccactcatc actaaacaga gtaaaatgtg atgcgaattt tcccgaccaa cctgattcgc 22980 tagatttttt ttaaggaaaa gcttggaaag ccaggacaca acgctgctgc ctgctttgtg 23040 cagggtcctc cggggctcag ccctgagttg gcatcacctg cgcagggccc tctggggctc 23100 agccctgagc tagtgtcacc tgcacagggc cctctgaggc tcagccctga gctggcgtca 23160 cctgtgcagg gccctctggg gctcagccct gagctggcct cacctgggtt ccccaccccg 23220 ggctctcctg ccctgccctc ctgcccgccc tccctcctgc ctgcgcagct ccttccctag 23280 gcacctctgt gctgcatccc accagcctga gcaagacgcc ctctcggggc ctgtgccgca 23340 ctagcctccc tctcctctgt ccccatagct ggtttttccc accaatcctc acctaacagt 23400 tactttacaa ttaaactcaa agcaagctct tctcctcagc ttggggcagc cattggcctc 23460 tgtctcgttt tgggaaacca aggtcaggag gccgttgcag acataaatct cggcgactcg 23520 gccccgtctc ctgagggtcc tgctggtgac cggcctggac cttggcccta cagccctgga 23580 ggccgctgct gaccagcact gaccccgacc tcagagagta ctcgcagggg cgctggctgc 23640 actcaagacc ctcgagatta acggtgctaa ccccgtctgc tcctccctcc cgcagagact 23700 ggggcctgga ctggacatga gagccccttg gtgccacaga gggctgtgtc ttactagaaa 23760 caacgcaaac ctctccttcc tcagaatagt gatgtgttcg acgttttatc aaaggccccc 23820 tttctatgtt catgttagtt ttgctccttc tgtgtttttt tctgaaccat atccatgttg 23880 ctgacttttc caaataaagg ttttcactcc tctccctgtg gttatcttcc ccacaaagta 23940 aaatcctgcc gtgtgcccca aaggagcagt cacaggaggt tggggggcgt gtgcgtgcgt 24000 gctcactccc aacccccatc accaccagtc ccaggccaga accagggctg cccttggcta 24060 cagctgtcca tccatgcccc ttatctgcgt ctgcgtcggt gacatggaga ccatgctgca 24120 cctgtggaca gagaggagct gagaaggcaa caccctgggc tttggggtcg ggagcagatc 24180 aggcctcagt gggctggggc cggccacatc caccgaggtc aaccacagag gccggccaca 24240 Página 171

P201430887 ES 2 553 786 A1 09-06-2014 ggttctaggc ttggtactga aatacccctg ggagctcgga aggggagttg agatactgca 24300   gggcccatag gaagaagtct tgggaggctc cacctttggg gcagaggaag aagtcttggg 24360 aggctccacc tttggggcag agcaagaaga gggcggaggg cagaggcagc gagggctcat 24420 cctcaaaaga aagaagttag tggcccctga atcccagaat ccggggtgca cggctgttct 24480 gggggccgct aggggactaa gaggatcggc cgag 24514 <210> 14 <211> 35953 <212> DNA <213> Homo sapiens <400> 14 ggcaggggtg gctcgccgca tgcccaggct ctgccccaac ctccgcgccc aggctctgct 60 gtccctgccc tcccggctcc ccaccctcag gccccaggag cggcagtttc tgcaggagct 120 cctgacccgg ggcctctcgc gggaggcctg agcaagccgg acacaggaca cggggtaggg 180 gaggggtcgg ggggctgatg gggggaaccc tgcacccccc agggcagctg ctaccaaggg 240 gcgagtccca gggcccccgt cggccctgcg tgcggggcgc ggtccccaac acccagggcc 300 ccggaggcgg acacagcccc agccaggtcg tccgggaaat ggggcggggg cgacgggcgg 360 ccgggcccgg gacgcgaagt ccgagcagca gcgggcaggg gctggcgggg gagctcggcc 420 cgggctgcag gggggtcccc accctctcca cctcctccag cctcccgccc tcgagggtcc 480 ccgcttccct cccatccccc tcccgtgccc ccggccccct cctcccatcc gcggggccgc 540 agcgcttcct ggcggcgggg cgggtcaggc cggcggggcg gggtataaag ggggcggcgc 600 cggccgcggt tccctccctg ctgcttactc ggcgcccgcg cctcgggccg tcgggagcgg 660 agcctcctcg ggaccaggtg agcgcctccc ggaccccgca ccctggaagc cgctcggccc 720 gcggggggtg accccgagtc ctgggaaggc ggcggcggcg gctccgtccc tcgggtcccc 780 gggaaggggg actccagccc cagggacggc ggggggctcg gcgggttcgg ggctcctcct 840 cgcggggctg gggccgcgcc tgcccctgtg gctccgcgtc tctgggtccg accctcgggc 900 gcgcgacttg gggccacctc cccgcggcct cctctggggc ggagccggcc tgggcggggt 960 gggggggtcc ctgtctgcgc ccgagctcgg tgctgggacc cccgctcccg agacgacccc 1020 ggcaccgcac gccccgccag gccccgcgtc tgcgagcggt tcgggtccgg ctccggcccg 1080 cggggaagac gccccggctg gctgggacct ccgggggcgc agggcctctc cccgggccgg 1140 acggaagggg cggcggggcg gggggaggag gggctttcgg tgcccgaggg cgggactggg 1200 cggggagggg acgcgggtgg ccccgacgcc ccatcgctgc gcccctcccg gcctggagcc 1260 caccagggcc ccgccaggcc caggagaagc tgcagacgga ggcggctccc cagggcggcg 1320 ggacccgggc tgacagcgac ccgcagcccc tgccgggccg cccacacccg ccctgggact 1380 ccgccggggc gctggtggaa ccgctgggcc tgggtctcca ctgctggcaa ccgaacggat 1440 cggccctctg tggagccgca ggtgtgcggg cgagcggcgc ccatccgggc tgtgccagca 1500 gaaccccggt gcccgcgcct aggacgcccc tggagaaggg accttccctt tggggtcgga 1560 acccagaaag gaggggcctg cgatccgcgg agctccttgt tcttgggata acacagctct 1620 Página 172 ggcttggagg cccccttgca cttcgactct ggtgattatt tcaagaaagg ccagaccggg 1680 cacggtggct cacgcctgta atcccaacac ttggggaggc cgaggcgggc agatcacctg 1740 aggtcaggag ttcgagacca gcctggccaa cagggtgaaa ccccgtctct actaaaaata 1800 caaaaaaaaa ttagccgggc gtggtggcag gcacctgtaa tcccagctaa tcgggaggct 1860 gaggcaggag aaaatcactt gaacctggga ggcggaggct gcagtgagct gagatcgcgc 1920 cactgcactc cagcctgggt gagggagcga gactgtctca aaaaaaaaaa aaaaaaaaaa 1980 aaaaaaggaa agaaaggccc ggtgagatgc tttctcttaa acacggccct gcacgttgag 2040 ttgctgcctc ctgtggccta tttcacgttt atgcaaagtc gggcgcctga tgcggggctc 2100 acccgccaca agcaggggtc ctggtgctgc tcatggaagg ggccctaccc agcccgcggg 2160 gcactggctg ggacggggct gcccaggtcc gcccaggatc caaacaccca gccccgccca 2220 gcggcccttc ctggcctgca gtggaggctg taatgggcag gggtggtggg aatcccagct 2280 cacagggcgc ctgctcttag aagggcggca tctgggtcca gaggtcagaa acgtcagatg 2340 cccatcccag aagtggcggg gaacctgtct ccacaatgga tagcagcact gtcttttttt 2400 tttttttttt ttttttctca tttcatagat aaggaatgat gccttgttgg ggggtttgtt 2460 ctgcatgtct ttggtttttg tgcagtacaa ggctatttgg gctgtttgat cactgaccgt 2520 gtgtagtgat gtgcattgcc tggttgtgat gtccccatgt tcctaatgga tgttcgcttt 2580 ttgggttttt ttggtttttt gtttgtttgt ttgttttttg agacagggtc ttgctctgtc 2640 acccaggctg gagtgtggtg gtgctatcac tgctcactgc aatctgcaca tccctggctc 2700 aagcgagcct ccacctcagc ctccgagtag cggggactac aggcatgcac cactgtgccc 2760 agctaatttt cttttaagag acggggtctc actatgttgc ccaggccatg gatgtgtttg 2820 tttgtttgtt tgtttggggt gtttgggggg ttttttcttt ttttattgat ttgaaaaagc 2880 tttattttcc cgaatttttt attgtggtat acaatataaa atgtactgtc ttaaccattt 2940 ttaagtgtgc agctagttca gcgacagtaa gtacattcat agtgttgtgt agccatcacc 3000 aaggtccatc tccggaactc ttttcctctt gtcaaactga agcccatgga gcaccaactc 3060 gcatcacccc ttccctcccc tggcagccac catcctactt tatgtttcca ggaatttggc 3120 catttaggtg actcatatga gtgaaatcgt atgaaatgtc tccttttgtg actggcttat 3180 ttcacgtggc ttaatgtcct ccagattgat ccacactgta acgtatgtca gcattccctt 3240 cctttgtaag gctgagcagt attccactgc atgcatgccc tgcattttgt ttacccattc 3300 gtctgttgct ggacacttgt gttgcttcca cgtttgagct actgtgaatg atgtggccat 3360 gaacacacca cacagatacc tcttggagat cccactttca cttcttttga gtatgttccc 3420 agaagtggaa atgtggatca tttgattttt tcattttttt gagaattaat tgcctcactg 3480 tttcccacgg tggctgcacc attttgcttt cctgccaaca gtgcacaagg gtccagtttc 3540 tccacatctg caccaacagg tgtcattttc cgggttcgct tggttttttt taaatgttaa 3600 ccatcctaat gggtgtgagg tggtatctca ctgtggtttt gacttgcatt tccctcatga 3660 ttagtgacgt tgagcatctt ttcatgtgct tgttggccat ttatatatct cttgggagaa 3720 Página 173 atatctgttt aagtccttga cctatttttg aatcaagttg attgtttttt gttgttgaat 3780 tttaggagtt ctctgtatat tctggatatt aatcccttat tagatacaca gtttacagat 3840 attttctctc attctctggg ttctttttac tctgttaatg atgtcctttc actagataga 3900 tgcaaaaaat gtttttaaat tttggtgtaa tctgatttat ctattttttc ttattgtcat 3960 acccaagaaa tcattgctca gtcccatgtc acgaaggtgt taccttatgt tttcttctaa 4020 gggttttaaa gttttaggtc ttaaaacgta aagatccatt ttgagttaat ttttgtatat 4080 ggtattaggt aagggtctaa cttcattctt ttgcatgtgg atatctagtt gtctctgcac 4140 cgtttgttga aaagactgtc tttatcgaat ggtcttgacg gcttgattga aagtcatata 4200 tgcaagggtt tctttctgga ctctctgttt tattctgttg gtctgtatgt ctgtctttat 4260 gccagtgcca cactgttgat gactgcagct ttgtagtaag ttttgaaatt aggacatgtg 4320 agtcccccag ctttgttctt atctttcacg attttttttt tttttttttt tttttttttg 4380 gctattcgag gtcccttgag attccatcta aattttagga tttattcact atttctgaaa 4440 aaaaaaacaa tcactgggat ttttataggg attacattaa acctctagat caatttgggt 4500 ggtattgaca tcttaatata gtaagtcttc caatctatga acatgaatgt ctttttttaa 4560 atgtcctctt caatttcttt cagaaatgtt ttgtagttct cattgtacag gtctttcacc 4620 tcctaagtca atttttaagt attttattat ttttgatact atagtaaata gaattgtttt 4680 cttaatttcc tttggattgt tcattgttag tgaatagaaa tacaagtgat ttttatgtgt 4740 ttactatgta ttctgctatt ttgctgaatt tgtttattag ttgtaacagt ttttgtggaa 4800 tttttagggt tttctacata caagatcata tcatcagtga tcagagataa tttacttatt 4860 tctttccaat ttgaatgcct ttaatttctt tttcttgccc aattgctctg gccagaactt 4920 ccagtacagt gttaaataga agtagtgaaa gcaggcatcc ttcctttatt tctgacctta 4980 gaggaaaagc tttcagtctt tcaccactga gtatgatgtt cactgtggct ttttcgtata 5040 atatggcttt tattatgtta aggttgtttc cttctattcc taatttgttg agtgttttta 5100 tcatgaaagg gtattgaatt ttgtcatatg gtttctctgc atcaactgca atgatcatgt 5160 gtgagttttt tttcctcctt cattctgtta atgtgtatta cattgattga tttttttttt 5220 tttgtatgtt gaactatcct tgcactccag aaataaatcc tacttggtca attcattaaa 5280 ttccatttaa ttgcatcaaa ttataccaaa tttagtttac tattaatagt attttgttta 5340 ggatttttgc atcaatgttc ataaggaaga ctggattgta gttttctttt cttgcaatat 5400 ctttgtctgg tattggtatc agagtaatgc tggcctcata agaatgagtt aaatagtgtt 5460 cccttctctt caagtttttt gaaaattttg ggagggtttg gtgttagttc tttatgtgtt 5520 tggtagaatt caccagtgca gccatcaggt ccagaggttg tttgtcagga gatttttgag 5580 tattgattca atctccttac tagttatgtc tattcagatt ttctatttct tcatgatttg 5640 attttgtctt gataggtttt gtctgtctgg aaatttttcc attccatctg tgttattcaa 5700 attgttgaca tatagttgct tatagtacac tcttataatc ttttttattt ctgtagaatt 5760 agtagcaatg ttgccacttt cacttataat tttagtaatt tgagtttctt ctttttttct 5820 Página 174 tagtctagaa tctagcttaa ggctggtcaa ttctgttatc ttttcaaaga accaactttt 5880 gttgtcattg attttctcta ttatctgtct gttctccatt ttgtttatct ttgctctgat 5940 ctttattttt tccttctttc tgctagcttg ttctttttct agttccttac attgtaaggt 6000 taagctccta tttgagacct gtctttttta atataagcat gtatagccat cagtttcccc 6060 cttagcactg ctttcactgt cgaacaagtt tttaaatttg tgttttcatt ttcactcatc 6120 tctaagtatt ttataatttc ccttgtgatt tcttctctga tccttggtta tttaacaggg 6180 tgttgtttaa tttcgtgatt ttttaaatgt ccttgttgct gatttttaac tttactcctt 6240 tgtggtctga aaagatatct tgtatgatgt agatctttca aaatctattg acacagactt 6300 tgttgttgca actaaccccg tcattgcaag cccttctccg tctggttgaa gtgacttcca 6360 ggagatttaa agggctggca cccttttctc ccttcatttt tctctttttc ctcttttgag 6420 acgtagacat tgaagactag cacattcaaa agcaaccata tatgtggaga aaataaaaaa 6480 gtcattgcac atgctcaggg gaagtcacgg gcttagaaaa gacctaagaa gaccttaagt 6540 ttatacttta tgctgatcct tagcacagag acagcaacaa tcaaaattat aaaaacaaga 6600 aaaaccagca aactctgggg aagaaagaga ttttgatttc acaaggcata caaagaaact 6660 ttcctatttc aaaggaaaaa aaaacaacag aaactgtcac tgaaaaagac ttggtggtag 6720 atctactaga caaaggcttt gaaagaacta tcttaaagat actcaaataa ctaagggaaa 6780 atgtggagaa agtgaaagaa aatgtaggaa caaatgaaaa tatcaataaa aagctagaaa 6840 ttttaaaaag aaaccaaagg gaaattctgg agctgaaaag tacaataact gaaatttaaa 6900 attcactaga gaaatgcaaa ggcagatttc agcaggcaga ataaagaatc agggaacttg 6960 aagatacaaa aatggaaatt attgagtctg aggagcagaa ataaaaagat tgaataaagg 7020 tgatcagagc ctaaggggtc tgtgggatac catcaagcaa accaacataa acattgtagg 7080 agccccagaa gaagagagag caaagggagc agagagacta tttgaagaaa taatggctga 7140 aaacttctaa aatatgatga atgacatgaa tataaccatc caagaagccc aaaaagctcc 7200 aagcaggatg aactcaaaga gacccacact gaaacattct aatcaaattg tcaaaaccca 7260 aagacaaaga ttttgaaaac agcaagaaag aatgattcat cacatgtaag gaatcctcaa 7320 taaaactatt agcagatttc tgatcagaaa ctttgaaggc cacaaggcag tgggccaata 7380 tatccaaagt gctaaaagaa taaaaactgt ctaccaagaa gcccacatcc agcaaaactg 7440 tcctttaaaa gtaagggaga aattaacaca ttcttagatc aacaaaagct gagaatgttc 7500 cttaccacta gacctgccct ataggaaacg ccaaagggag tcctgcgggt tgaaataaag 7560 ggtgatagac agtaattcaa gtgaagaagt aaagatctca gccaggcata gtggctcatg 7620 cttgtaaccc catcactttg ggaggccgag gcaggaggat aacttgagcc caggagttca 7680 agaccagcct gagcaatata gggagaccct atctctataa aataaaaata tttttaaaaa 7740 tcgaccaagc atggtggtgc acacctgtgg tcccaactac tggggaggct gaggtgggag 7800 aatcatttgg gcctgggagg ttgaagctgc agtgagctgt caccacacca ctgcactcca 7860 gcctgggcaa cagagcaaga ccttatctca aaataaataa ataaataaat atctcagtaa 7920 Página 175 aggtaaatat atagacaatt ataaaagcta atattgctgt aacaatggtg tgtaatgctg 7980 ctttttgttt tctacataat ttaagagact gatttaaaaa taacattatg cttttggaca 8040 cataatatat aaaggtgtaa ttttgtgaca tcaataacta aaagggttgg ggacagagcc 8100 attcagggag cagagttttg tttatgccat tgaagctaaa ctggtataaa ttcagtgtag 8160 actgttataa ttttaggatg ttaaaatgca atccccatgg taacaacaaa gaaaataact 8220 aaagaataaa tacaaaaggg aatgaggaag ggatttaaat gtttcaccat caaaaaaatt 8280 aattaaacac aagacagtga tactggaaat taaggacaaa aaaatccata aggtatacag 8340 aaaaaaaatg caaaatgaaa gaagtccctc tttatcagta attactttag atgtaaatgg 8400 attaaactct ccaaactctc tctgttaaaa gacagagatt ggcagaatgg atttagaaag 8460 ccaaatccaa ctatatgctc tctacaagag atgcacttta gatccagaaa cataaataga 8520 ttgacagtga aaggatgggc aatgacatgc cacacaaata gtaaccaaaa gagagcaaga 8580 gtggctatac taataccaga caagataggc tttaaatcaa aaaaggttac aagagggaaa 8640 gaaggacatc atatattaat aaaaggctca atacagcaag atataataat tataaatatt 8700 tatgcaccta ataacagtcc atcaaaatat ttatatctta cactgggaag attgttgctg 8760 gctctcagtc tgcttccagt ctgctcatat tgcttttgtt gtaatgatgg tcatatgtgg 8820 gagctcagtg tcaagagggc agacttgagc ccacactgcc aggcttcaga cctcagctat 8880 tagctgagtg ccctgggcaa gttacctcac tgggccttgg tttcctcatc tgttggagtg 8940 gggatggtaa tagtacctat gtccaaggcc ataagtccaa ttgtgaatgt tgaatgaagg 9000 gatataggac agtatctggt acacaattat tatagatttt tcattgacat tttatacatt 9060 ctgttttctt caaagacttt ttggttcctg ttttgcactc agatacttcc ttttcctgga 9120 gtttatttgg gagcaccatg tgaggtagta cctttatttc tagtcacagg gtgagccctc 9180 atcccagcct gcttccacca ctctgaaagg ccaccatgtc atagcctaag ttctcgtgtg 9240 ttgttatgcc catggttgtg tggagtgttg gcctgttcca gcaccaaaac caaaactgta 9300 attttatcgt ttcatttgat agcacaagct ttctcatcac tctatttttt attttgctca 9360 actcttcttg ctttttctac caagtaaaac ttggattcat tttgcaaact cctatctaca 9420 aaaatgcaaa aaattttctt ggaaacttta attaaaattg cattctatta tagattcagt 9480 taggaataac tgatattttt aaatcagttt aagatagtgg gatgatttct tatccaaaaa 9540 caaggtttgt ctttccaata tatttctcaa aaattttttt gagttttttt cataagtcct 9600 gcacattttt attcagttga ttccttgggt ttatgttgtt tttcttacta gtgtaaatag 9660 catttttctg caacattttc taactggttg ttagaaaatg tttcttctaa ctgatagaag 9720 aaaatcaata actttttgta tgttgaggac taagctctga tttttttatc ttgcctatat 9780 tcttatctaa ggggtctggg gagtcatgcc ctacaaacca taaattctca tcagatggtt 9840 ttatctaacc ctatatgctg tgacttactt tccatctgac tctggcatga cactacacga 9900 ccaagaagaa aataaaaata ttttacccca aaacatgttt ctttgccaca ttttgaaatg 9960 gccctgcaaa gctgtccttt actggggaaa atttgcatct gtaaggaatc tctgttaaca 10020 Página 176 tagctagctc tttttcttcc aggccctccc aattctgaag agattaaccg agagtctagc 10080 agcttttaaa ggtctcagta ggaaacactt gtcattgatt gtctctaagg gcagccacta 10140 tgagacttca gaagaacctt ggtctccaca gtcttttatc ttaacctgag catttccttt 10200 ctatgatccc aggtctttag acaaactcaa ccaattgtca accagaaaat gtttaaattt 10260 acctgtagcc tggaagccat ctctccccgc tttgaatttt cctgcctttc tggattaaac 10320 caatgtattt cttaaatgta tttgattgat gtctcatgcc tccctaaaat gaataaaacc 10380 gagctgcacc ccagccacct tgggtacatg ttctcaggac ctcctaaggg ctgtgtcatg 10440 ggtcatggcc actcatattt ggctcagaat aaatctctta aaatatttta cagagtttga 10500 ctcttttcat caatgatata tttttctaag tggctcacta aattttctct ccctaatctc 10560 ccctcctttc tctttctttc tctctttctc tctgtctata tatatatata tttttttttc 10620 tcttttttaa aaaaactttg ttcagatgat tttctgggta gacaatccta tctttaataa 10680 ggacagtttt gtctcttctt ttccaacagt tatactttta tttttactgt cttattgcat 10740 tggcttccaa cacaacactg aatggtagcg taagatctgc actgtttgcc cccaccccat 10800 tttttttgta ctgtagtaag cattcttcta atgcaggatt ttttaaccca gggttagatc 10860 tacgaatgga atccctgaat tcctggacat gatttctgta tatgagcatc tatgcatttg 10920 tgtaaggtga aattgtgtag actcttaaaa gggtccatga ccacaaagat aagaaccact 10980 attttagctt tttgtgtaaa atatgatgtg agctcttgat ttgaaatgta tatcctttat 11040 agagttaatt ctactcctaa atttcttact aggttttacc ttgtctggct gttgttgttt 11100 cttagttaga aattgatgtt tcagggatct attgaagcaa ttgcatattt tttcccattt 11160 tatgttaatg tgacttacat taatgtattc cctagtgttt gtggcaacac tgtactttaa 11220 cttcatatta tagttctggt atagtggtcc ttaatatgct attggatttt agtttttaat 11280 attggctaga atttttgtga taatgttatg ggatttttag ggtgtcactt ttctggcctg 11340 aaacctctat ggccagtggc gcctttgccc aagttcttgt cctgtgtcca ggaagaatga 11400 ggtacacaga caagtggagg gtgtgcaaga cagagaagct ttattgagtg ttaggggagc 11460 tcacaggaga cccgcagggg gcagcccctc tctgtaggcg ggttgtcttg tcggcgggtt 11520 gtcttgtcaa atgttcagct ctcagcagag agaaggccct ggagtgggtg gctcctctct 11580 gcaggcaggt catcccattg tctctgcagc tcttagcaga gaggaggccc tcgagagcgt 11640 gtctcctctc tgcaaacagg gcatctcaac tagtgttcag ctctcagcag agagaaagcc 11700 ctggagaggg tagctcctct ctgcagctgg tcgtcctgac atcccttcag gtcctgaagc 11760 tctcagcaga gagagcacct cctctctgca gctggtcgtg ccatgctctg ccctgctctg 11820 actgagcctg gggcttttaa aggcctcaga gaggggaagt gcatgctgat tggtccatgt 11880 gcagccatgt gcaggcccag aagaaagcac cttgagttcc cctctggtcc gtaggacggg 11940 caacccggcc cccaggcttc aggcctgccc cagcctgaag gtggggcttc actggggacc 12000 catcctcttc tgcccaggag cctatctgcc tcctgcagcc atccatggtg cccaggctgc 12060 tggtaccaag gggcaccggt gcccagccac cctcagcacc cccccaagcc tcccctcctg 12120 Página 177 cacttctcag tgcccacagt ttggaggggg ccaagtcagc agggggctgg catgtcagca 12180 ctgccacaag catgcaccca cccggccagg ctgtgacagt gcccaggctc agccccaact 12240 ctgctctgag attggagtgg gtggtgggag cgggaagaag ctgggcagcg ggaacaggca 12300 cctccaggcc tacaagggaa agaggggcct tccctggctc cccaagagtg cagcgatgcc 12360 tgggtcagca gccccagttg gggcagctga aactgcacca ggagtggggg ctggctcctg 12420 cctcctccat ggagcagaag gcccagatcc acagccacga cttgggcagt tgtacctggg 12480 gaactctcac ctcgccaaac tgcaaggggc agggatccca cttatccccg gctcctgctg 12540 gctccgtgga gcatggtacc tggccatgtc ctctcgcagc ctggggcagg gtctccagac 12600 ctgggccagc atcccagaca ggggcaacac cgccgtgagc tccccttcac ccagcacacc 12660 acccggcccg gccccatggc agcggccccc agggaggcag tctgcggggt tgggggcctg 12720 tctgcctctt ccatgggccc tccctgagca gccagtgtga tggcagcggc cacaccagat 12780 gggctgccgc tgccatcagt aatatttata gtgatattta tctgtagagt tacttttagg 12840 gacttttttt tttatcaagc tttggtcaca ggttatgcaa catttaaaaa tgaattggga 12900 aaaagtttat ctttttatgt tctaaaacaa gttaaatagc atgaagtgct tgtccttgaa 12960 gctgtgaaac tcacccacaa actgcctgag ctggcacctt tgggaacgga cttcattcct 13020 ccctgggccc caggctgagc aggtctggcc tgggtcacct catccactcc agacgccgca 13080 aaatcacagc aacccttcag ggccctctcc tggcagcgcc tcccctagtc ccggtgcttg 13140 gacactcctc ccatctgcac cgaggagagg gcggcactcc aatccctgca ttacccctgg 13200 aactgcacgc tctgaaccag gcccggtgcc ctttctgccc agctgcccgg ctgctgccag 13260 ccccactctg cggagccagc agcacagtga ggcccgtcct gatggcctcc tggagctgga 13320 gcttaggcca agccacaggg catcagggag gatggacgtt caagggctgg atctgtttgc 13380 cccagggtcc tggcacccaa cagaaaggaa agccaggcta atgacggctg tgtccctaca 13440 cttgacagag tcctccctcc ctccttatca aagtcctgtt taaagggaat ggagccaggc 13500 tggagagaga gtgcctagct ctgcagggga gccggtctgg ggaagctggg atctctctcc 13560 cgccctcccc tctgcactgt ttccagggca gccccaggca gtggggggcg ccagacagtg 13620 gtgctccatt cccttccatg ccgacgcgcc cagctaccca ctccacccag ccctggagga 13680 catggaaggg cctcaaccat ccaaatccca cccaaaactg agcccagagg cacccactaa 13740 acatctgtga ccccacccag ggtggggcaa gagggcgcaa gccccccagt ccagatgctg 13800 gtgacggtgt gtgctgggcg cagaccccgc ttccttgaag actgagggca gtgcccccaa 13860 tcccgctgac ctgctgtgcg tgcgcctgcc atgggggagg gtgccagggg agaggcactg 13920 ggggtgtctg agcgaccccc acccctgttg caggacttca gggccacagg tgctgccaag 13980 atgctccagg gcacctgctc cgtgctcctg ctctggggaa tcctgggggc catccaggcc 14040 cagcagcagg aggtcatctc gccggacact accgagagaa acaacaactg cccaggtgcc 14100 aggggtcggg ggccgggggc tctgggcatt tggggggcag ttgggaccag tacccaggtg 14160 ccaggggtcg ggggccgggg gctctgggca tttggggggc agttgggacc agtacccagg 14220 Página 178 tgccaggggt cgggggccgg gggctctggg catttggggg gcagttggga ccagtaccca 14280 ggtgccaggg gtcgggggcc gggggctctg ggcatttggg gggcagttgg gaccagtacc 14340 caggtgccag gggttggggg ccgggggctc tggcattcgg gggcagtgag gtcaaaccca 14400 caaacaggca cggggccagg aaacggggct ccaacagcag tccctcctga ggctggctcg 14460 tgacaggtcc tgtgccccac agagaagacc gactgcccca tccacgtgta cttcgtgctg 14520 gacacctcgg agagcgtcac catgcagtcc cccacggaca tcctgctctt ccacatgaag 14580 cagttcgtgc cgcagttcat cagccagctg cagaacgagt tctacctgga ccaggtggcg 14640 ctgagctggc gctacggcgg cctgcacttc tctgaccagg tggaggtgtt cagcccaccg 14700 ggcagcgacc gggcctcctt catcaagaac ctgcagggca tcagctcctt ccgccgcggc 14760 accttcaccg actgcgcgct ggccaacatg acggagcaga tccggcagga ccgcagcaag 14820 ggcaccgtcc acttcgccgt ggtcatcacc gacggccacg tcaccggcag cccctgcggg 14880 ggcatcaagc tgcaggccga gcgggcccgc gaggagggca tccggctctt cgccgtggcc 14940 cccaaccaga acctgaagga gcagggcctg cgggacatcg ccagcacgcc gcacgagctc 15000 taccgcaacg actacgccac catgctgccc gactccaccg agatcgacca ggacaccatc 15060 aaccgcatca tcaaggtcat ggtgagccgc gggcgggagc accgtccacg cgccaggggt 15120 ggccacggtg ggccgtccac ccactccggg cctcacttta cccctctgtg agtgcggagg 15180 ccgaaggagg aagctccggg cagggcctgg gccactcagg tgtccctcca tccccaccca 15240 gactcgaggt gcagccgccc caggtctcga ggcacacggc taaccagcat gtctgtcttt 15300 tctgcagaaa cacgaagcct acggagaggt gagtggcgct tcccttcctg ccagtgctgg 15360 ccggcagctg acccagcaga gatgaccgcg ccaggctgcc gactcctggc gcctccaggc 15420 tggaacagat gagaggagag ggagtcacct gctccatgtt ggacctgagg ccttggagtc 15480 tggagaaagg gctcccagcc aaagctaggc tgtttagatc ccgtgagggt cagcgttagg 15540 gtcacccaca gagcacgtgt tacaaggaga ggtcgagggt ctggcctccg ggcaggtggg 15600 atccatccac cctggactcg aggcccgagc ccagcccagc aggtcagggg agaaggaact 15660 gacatcatcg gggtccatga catccccacc tccctgtgtg tcccagctcc agctctcagg 15720 aaggggagca ggcatctgag atctcccccg tgaggcttcc tgcaaaaacg tgccctgcct 15780 cagaatcgct gctcagtaac agtggtttca ttgccgtgta caaatggtgc ctccctcacc 15840 agtgcccctt gctcttccat ccttttgtaa aatttattct tttatatttg tttttttaga 15900 gacagggtct ttctctgtca cctaggctgg agtgcagtgg tacgatcacg gctcactgca 15960 gccttgaact ctgaggctca agccatcctc ccacctcagc ctcccaagta gctgggacta 16020 caggcacctg ccaccatacc tggtgtgcgc atgtagttcc agctacttgg gaggctgagg 16080 tgggaggatc gctttcgtat tgtttttttg tagagatggg atctcactat gttgcccagc 16140 ctggtctcta actcctggcc tcaagcagtc ctccctgcct cggcctacca aaatgttggg 16200 attccaggcg tgagctgcac ccggcctttc ttcccttcta ttttctgtca tggcttaagc 16260 caggcttggt tttttaaact tgcctagaac acctgaccga gagccaaact ctttggcttg 16320 Página 179 tccctgatgg gggcagagcc tcacagcacc ccatgtctca cagctccctc acgcccgccc 16380 aggttctcag ggcatttcag catctccttg gcccctgctg agagtcgtgg gctacacgtt 16440 ctgagaccct gccctgccac ctgaggaatg tcccacccat gcaaccttct gtctctgctt 16500 cctcgtttca gtgctacaag gtgagctgcc tggaaatccc tgggccctct ggccccaagg 16560 gctaccgtgg acagaaggta agatgcccag attacctgca gggtctgcgc taccaggaag 16620 cccctgattt gttttgaaat ccacacttgg ccgggcgtgg tggctcatac ctgtaatccc 16680 agcactttgg gaggccgagg cgggcggatc acaacgtcag gagatcgaga ccatcctggc 16740 taacatggtg aaaccctgtc tctactaaaa atacaaaaat tagccgggcg tagtggcatg 16800 cgcctgtagt cccagctact cgggaggctg aggcaggaga atcgcttgaa cctgggaagc 16860 ggaggttgca gtgagcagag atcacgccac tgcactccag cctgggcaac agagtaagac 16920 tctgtctcaa aaaaaaaaaa aaaagaaaag aaagccacat ttaaggccag ctgtatctca 16980 aattgtctca acacttctgt ccctggagaa actaaaactc tatatgtcta attcctttta 17040 aatagtatat tgagaaaagc agaagcttgt aaaaaatgag atatgccatt aaaatacttt 17100 ggtaagcaag catattcaag taagtaaaat gtgagatgca ctacacttaa taatatgatt 17160 gctcattaat atgaaggaac ctcttttgtg gcttactaaa taagcagttt tagggagcct 17220 ggtttgaatg tcccctgcat tttctggttt gaacatcccc tgcattttcc taacagaggt 17280 gcatcaaata aagtccttcc aaaactcact aacagagtat gtgaaactcc aacaattcac 17340 atctgttaaa aattataaag aaaagcatag gaggagaaag tagcttctaa ggagatgaaa 17400 taaggaattg accatcatag aggatgttac tgctacgtag cttcgtgttt ttctaaattt 17460 ggataacagc tgtctagacc agtaggtatc tggatgtact ttctccagga tgagacatct 17520 cgaggctgca ggtcaaatcc tgccatctcc ctccctggct tctccagtcc tggtggcaat 17580 gccgacccta ctacagctgg gaatgaattt gccacttggg gcagccttgg ctgcacacag 17640 cagtgcagtg acccgttctg ttgggggggc cactggaagc tgccacaggg atcactgtgg 17700 ttagagtttg aggggtggca aggtgccaag cggagcccag gacagggcac agctgtgatg 17760 ttccagaagc ctctgcccac ctcatcccct gccctgagtt tcctcccttt tcttcctttt 17820 gacctcttaa ttcttcccct ttcctctgct cctctttgca cttaaattgg gagcatatca 17880 ataaatagat gaatttattt aataaagttc tgtatcatag gttaaaattt taattccaag 17940 agagtgtaac ctttatgtgg tgttctgaag tcctgatctg tctaaagtta cttagataaa 18000 ggaattaatc tttgtagtga cggtgaccca ggcatcgctg gagaatcaga gcccagtgtt 18060 ggccacagtc acagctactg ggtgcagaag ggacccccac gggccaggca cccccacccc 18120 aggggtctct tctggctcca ttttgcaggt ggctttgtgg gaagcttccc tcagagctgg 18180 gagaaatggg tcaaagcaaa cccttgtctg acagaggctg gccctttggg gagcagctga 18240 caccaagact tctccacttg ggcaggggaa tcagtaacct ctgctgtgtc acctctcaga 18300 ggagctgtgg cagggtcccc agctgcctac cgcccaccct accctgcctc gatgtactct 18360 tttctctgct tttagggtgc caagggcaac atgggtgagc cgggagagcc tggccagaag 18420 Página 180 ggaagacagg tgagtgtcct tgccccacgc ccgccccgcc tgcagcccag cgccccaggg 18480 ctgggctcac actgctgcgt tgtccttcac agggagaccc gggcatcgaa ggccccattg 18540 gattcccagg acccaaggtg agtgacctcg gccaggggct tggctccacc ctgaggcccc 18600 agcactgcca ggcaggctcc ccccagccca gcctcggcct cagcctctac gaccctcccc 18660 ccagttacca aggaacagaa gcacctcgat aacttgatgg ccgtcccaaa acccagcctc 18720 cagcccgacc cagggctcag cctcctccgc agactgtttg tcgagaacac tagatgccag 18780 cggcccaccg agcactcccc tcagcctgca gggctggccc ttccctgcct gtgtctctgc 18840 agagctcctc actaatgccc ctctctcctc ctgcccccag ggcgttcctg gcttcaaagg 18900 agagaaggtg aggctcttgc cctgacagac ctcagacctg cgccagcctc ggcccagacc 18960 cacctcttgg cgtccgccgc agcctgtcac tgctcctggg gcaccggcct ggtcttttct 19020 cagtggtggc tttgggggct cctggggggt cctgtggcct tgagtttggc ccaagggctt 19080 tgccccccag aggcagcagt gcccatgatg ctttgaggca ccgagctcac tgcgccggct 19140 ttcctcctac acagggtgaa tttggagccg acggtcgcaa ggtaggctgg ctgggtaggc 19200 agagcccctc cttcctgctg ctcagggcag aaggaccggg gctaatggag ttccctcttc 19260 cttctctctt cagggggccc ctggcctggc tggcaagaac gggaccgatg gacagaaggt 19320 agagggagcc tcgggctcac agctggactg gtctcacaga ggcatcccag cctctgcagg 19380 gcccccagat ccagcctgat ctgtcagctt acacatgtgt acacacgcat acacacacac 19440 acacacacac acacacacac gaacttcagc tcctgccaca tcccactgcc ccacccaggg 19500 cttcaccagc ctgcatctaa ttcatggctg cacatcccgg cttggggcag ctccacagct 19560 gcacacagag gccagcaaca agcctaccca ctcccaggtc aaaccacagg acagccccac 19620 ccactccttc catggctccc cgtgggaaca tcctctgtgc ccagggagct ctgccctcag 19680 ggcctctggg aggcagccag ggatggcctg ttcctgcaca acggccactc tgcctccccg 19740 gagacagctc cacagcagcc gtggcctcat gtgggcaccc gtgtgccagg aggagagcgc 19800 tgcagccctg cggggcagaa ccgggtgggc tgtgtcttgg tcgttggcac acatggaccc 19860 cagaaccccg ccctgagact cctcctgccc ccttctcctt cagggcaagc tggggcgcat 19920 cggacctcct ggctgcaagg gagaccctgg aaaccgggta agggccgttt gcacccctcc 19980 ttcagcctcg gcccaggggg tgtgggtgcc tgaccgggtg ggagggtagt tgctgctgca 20040 gtgggagcgt gggttctccc ggcagcccag cagccccagc ccagcagccc cagcccagca 20100 ttctgccggg tcggagtcat gtgaggaact ccccctggga gctcctggcg gatccccgtg 20160 gcctggagac ctgatgcatc ccaaacttcg gtgtcactgg acagctccat ttccctgagc 20220 agcagatcca ggcctggcct cttggtcact gagcctgggc ctcacagtga gggtgggagg 20280 tgcgtcccgg gctgggacaa tggagcactt gggccctggc tcatggggag aaccccaccc 20340 gccgtgtgcc gagctccacc tctcactcct ctctcagggc cccgacggtt acccggggga 20400 agcagggagt ccaggggagc gaggagacca aggcggcaag gtaagtggcc ttgtcagggt 20460 acggggcagg cggggtcacc agcttccagg ggcctcctgg aggcagcccc agctgagaag 20520 Página 181 ctgagcagag agggcctttc tggaaacact ggtcagtgag gagccaatgg ccgtgggatg 20580 tggtggaggg tgccctgccc gttgcttcat cagcttctaa ccagggcttg ggcggccccg 20640 ccgctgctca ccgaggcctc ggcaacaaac ccacctcctc ccaggtggag ccccagggag 20700 ccccacccac acctcctgga gctccccatg ggaacgttgg tgccccaggg gctctgccct 20760 cctgggccgc ctgcagtgtc gccccgcccc tggcggcccc aggatcccca agggcttttt 20820 tctgggagct tggacttagg gcttcccact ttctgtccac cttccctcag cccaagccca 20880 agtctggctg agtcctctga gcagatgcac aggcgtcctg cccgtgacac acactctgcc 20940 ctcagctggc acggaggttc cagcagcccc cagccagcat ctggcatccc aggtgccccg 21000 tggacatcag ggaggtgcag tcccaagccc gaccgtgggt cctgcccccg cagcgggcat 21060 cctgcacccc ccttcccctg ccaaaagacg tgaggctgat tctgcaaacc cttccagggg 21120 gaccctggcc gcccaggacg cagagggccc ccgggagaaa tcggggccaa gggaagcaag 21180 gtgagcccct ctgcctcttc gcctgcagct gagctggcca cactcacgcc catggcccag 21240 atgaacagtc acgctggcca ccatctctgc tgtcaccatg gtgccgcatt gggctctggg 21300 gacacgggga gggacaggaa gaacaggcca tgtgccctga gccaccagcc cctctgacct 21360 gtgccctcct cacgaggctg aacaagttcc aggggaccct gcagggcccc catgtgcctg 21420 gcaagcagat tccgctggaa gataataggg gctccacacc acacaccgca caggcgtgac 21480 catgcctcag ggcccctgcc tctgggtgac tgtgctgtcc tctccttctt caggggtatc 21540 aaggcaacag tggagcccca ggaagtcctg gtgtgaaagg agccaagggc gggcctgggc 21600 cccgcggacc caaaggcgag ccggtgagtc cctcctgccc ctgcctcagg gccccgctct 21660 gggcatcctc cttgcagctt gaggaggacc atgggggaag ggcacctggg ctgtaggcag 21720 gatcccctgc tggcaaggca cagccaggcc cccatcctcc caagaagtgg acccggacca 21780 ccccacggga ccccccagag ctggacttag aggtaaagcc caggcaggtc ctccatggtg 21840 ttccctaaac ccagcaccag ctgcccaggg catcctgtga gggctgagca gggcccgtcc 21900 cagtgctgac cactccaagg ggactctgtc tgagcatggg gcctgcctgg gagtgaccgc 21960 agtgactgga cagcaccagg tccccaccag gccccagccc atcacctaaa acgccactca 22020 ccagacatcc aactccacct ggagcctccc cagatcattc ctaaatcctc ggcatgggcg 22080 ggaccgacgc agcagaggga cgagggctgg cagcagagcc actggcgcag gctgaggctg 22140 ttgggaagga gcctggggat cgaggtccca ggtcccaaag ccagagccct cctgtagaga 22200 aggagcatcg gccccggcac agcccccacc ctccacaggc tctgggcttg gactcagccc 22260 cctccctcac ccacacgcct gttctctgca ggggcgcagg ggagaccccg gcaccaaggg 22320 cagcccaggc agcgatggcc ccaaggggga gaaggtgagt cctcgtgtgg aggcagccca 22380 gggtctcact gtggtgccca tgggccctgc tgacgagggc cccaacccca ttcctcccag 22440 agaacaacag aaccccaggg cctcactctc cagagttcac tctctgcaga gtctgggaat 22500 gcagccctga gatccccaca ccccattctc tgctgaggaa gctccactac ccacccaggc 22560 acaccccgca cagctgtgca ggcaccattc acccccggcc cactgaggca ccactcacac 22620 Página 182 cccccggccc ccactgaggc acctcttacc cccagcccac tgaggcattg ctcacccacg 22680 tgacctcagg ggtgatgctg aagggctgtg tggtaaaacc ccggccacca gctccccttg 22740 acatcaggtg aaggggcttc ctcccaggaa gtggacgagg tcctacccac gtgtgggtgg 22800 cctcaggggg accgagagac accgtgctca gagcggcagc tacaggcacc gggaaggagc 22860 tatgggtgaa acaggcgact gttgcaggtc ccccgggaca gacggggttc ttcctcccag 22920 gcccccttcc ccaacccccg gccacacccg cctctcacat gggacccagg ccggaggcct 22980 cagctgagac ccgtggggcc tcccttccct tcccacaggg ggaccctggc cctgaggggc 23040 cccgcggcct ggctggagag gttggcaaca aaggagccaa ggtaggggag cagggtgggc 23100 cgcaccccaa ggtaggggat ctgagggggt gcaggggggc tgcaccccaa ggtagggtgg 23160 ccgggactgc accccaaggt aggggacccg ggtgggtgct gcaccccaag gtaagggggg 23220 cccaggtgag ggctatacct caaggtaggg gacccaggcg ggtgctgcac cccaaggtaa 23280 gggaccaagg caagggctgc accccaaagt aggggaccca ggtgagggct gcaacccaag 23340 ataggggtgc ttaggcaggg gctacaccca gaacccagcc tactccactc agtgtgctca 23400 gggctgaagg tcaagtggag ccacagcctc cggggagggt cataggggcc ggggccagac 23460 ccgtcttacc cccgaggccc tgcagtgtcc acaggattga tactggggac tccagggtgc 23520 tgctgtcagt caagagaacc ccaaattcct cccctttctt ccagggagac cgaggcttgc 23580 ctggacccag aggcccccag ggagctcttg gggagcccgg aaagcaggtc agtgtcagtg 23640 caggaggccg gtgccctctg accccacggg tgggtctccc ctatccatgt ggggacagcc 23700 tggagctagc cactgtcccc atagcaaacc caggcagcag agcctggcct cagaagccag 23760 gacctgctcc cctagacccc gagtacctca tacccaccct cagccccagc cccccatcct 23820 gccctgaagg acccaggttg tggagtcagg ggcaaggcag tgggcctgag gtcctggatg 23880 ggccacaggg aaaggaggag ctgggaccct caagacagag gtccacggcc cccacaggca 23940 gcaggaggag ctgcggccat gtggcctggt ggtcagggct ggacggggca tgtcaggtga 24000 cccctgggca tggccagtcc ctgcctgtgc tgacttctga atttctctcc tgccctcagg 24060 gatctcgggg agaccccggt gatgcaggac cccgtggaga ctcaggacag ccaggcccca 24120 aggtacgtgc ccctccccca gcaggacgta ttaggggttc ggggcagctg cctgaggagc 24180 aggacagggg gccggcctgg gggaccctgt tgccggcaga cgtgcctcag gacgggcctg 24240 tgcctcctgt tctcagctct ggagtgaggg gatgcctccg gggtccagga agcccccctg 24300 gctctcctct tcagcagtga cccttgggtg tgcatggcac atccttcctg aggcagggcc 24360 tgagggcagc tacgtggcct gagtagggtc ctccccgcgt gtgggcaggc ttcgggtctc 24420 taggcacgtc cagcccccac tggaggtgga cagggcgagg ttggccctgc caggcctctg 24480 ctcacagcca gaactcgacg gcacccctag cccacttcca ccccagtgtg caccttgcgc 24540 cctgttgagc acagcccccc agccccaccc cgtcctatga ccatgctgac cgactcaacg 24600 tcctcctcca gggagacccc ggcaggcctg gattcagcta cccaggaccc cgaggagcac 24660 ccgtgagtca cagcctggga tggcagctcc caggagtggg tggacattgt cccaagggcc 24720 Página 183 ctgaagattc ctagtagttc cctcaaggcc tcctctgtgc agaagaaagt gtgaggtccc 24780 tcctgcggga cagagtggtg agaaggcttc gggtgactca gtgaaggata ggtccagccc 24840 agcatcagga aaagagcaca gctcagaacg cagcacagtg gcctcaccca gagtgtgaat 24900 gagcgaggga gggaaacggg gctgcagaaa gctgcccaga gggaggaagg agcactggga 24960 tctgaggctg agtcaccctg gcttctgttt gcttcacagg gagaaaaagg cgagcccggc 25020 ccacgcggcc ccgaggtatg tgtgggtcct ggccacctgt gcccacccag ggtgggggtc 25080 tgcacgccca attgctggga acacaatgcc caccgtcact gacaggacca cccctgtctt 25140 gagatggtcc tggctcccca aggcccagcc atgtcaccta tgctgagctc tgggggagct 25200 gtcagccact ggctggtccc ttttcaacca aagttcaggc tttgcaaaaa aaccacatag 25260 atgctcccgt ttaaaggacc ccaaaatgcc agatcgattt ttccacataa aaatctcact 25320 ggtgtccctg gtagagacag ctcctctgtc ccaggctaac atgtgttccc tgtcacaggg 25380 aggccgaggc gactttggct tgaaaggaga acctgggagg aaaggagaga aaggagagcc 25440 tgtgagtgtc accgtcccga agcccacagc agctgggcag aggcagggag gggccctgag 25500 gctgagcgtg tgcatctatg agtacaggag aacgccaggc agcttggccc cagccatgag 25560 caccaccccc accttcctaa agggaacggc tggctcaggg gccccctccc tcaacccagc 25620 ctcccttcca gcgtcccctc cccagtgacc ccccaacatc ccccccacag catcccccac 25680 aagggtcccc tccctagtga cccctccaca acatcccccc agagtcccct cccagcatcc 25740 ccactacagc atcccccacc agggtcccct ccccagcgac cccaacatag catcccctcc 25800 agagtcccct cccccaaaag atgcctccac atagcatccc cctcagagtt cctacacaca 25860 gcattcccca agggttccct ccccaatgtc ctccccacag ttatccccca gaaggtgctc 25920 tgtgcctcca aatccctagc ctggccaagg gtttaaccag ggctgcaggt tggtctggaa 25980 ctgagcacaa aacaagggat ggataacgat ggatggatgg gcaagtggat gggggtgggc 26040 aaatggatgg atgggaggat gggtgatgga tggatgagtg aatagaagag tgggtggata 26100 gaagatggat gaatggatgg attgctggat gagtgggtgg gtggatggat aagtggatac 26160 atgggtgaat gagtagatgt atgggtgagt aggtgggtag gtgggtagat ggatgggtgg 26220 gtgggcgagt gtgtggttag atgatggatg gctgaatgga tgagtggggg gatggatggg 26280 tgagtgggtg tatgtatgga tgggttagtg ggtgggtgga tgaatggatg ggtgcataaa 26340 ggatggatgg atgaatgagt tagtgggttg gcagatggat ggatgggtga gtcagtggat 26400 agatggatgg gtgggtggat agaggatgga tggttgggta ggtgatgggt ggatgagtgg 26460 atagatgggt atgtgagtga gtggggggat gggtaggtgg gtggatggat ggttaggtga 26520 atgagtggat ggacagacgg acagtgggtg gatggatgag tgaacggatg gaccgatgga 26580 tgaatgggtg ggtgggtaga ggatggacgg acaggtgagt gggtgggtgg atggatagat 26640 gggtaagtga gtggatagat agatgggtgg gtggacagag gatgggtgga tgaatggatg 26700 ggttagtggg tggctgggtg gatggatgat ggatgggtga ctgggtggat ggatggatgg 26760 gttagtgggt ggctgggtgg atagatggat gggtgattgg gcgaatgggc gaatgggtgg 26820 Página 184 atgggtgggc gtggagttgg tgggtacatg ataatggggt ggaataccca tggattggaa 26880 tgagctgttt tggctgctat ttctgggaca cccagctctg ccaggcccct acccctctgg 26940 tgggccaggc tctgacggtg gccactcatg gcctttctag ctctggtgcc agcataggga 27000 aggaggaggc acagccttgt cttactcctt gcacctgtta gccccccccc ccgccaaggg 27060 aggacccgtg gttggggaca gcacaggggg ccctgctgtg tgcagggact gtccctgggg 27120 ccactgaagc ccacctgttc ttgttccttc tcaggcggat cctggtcccc ctggtgagcc 27180 aggccctcgg gggccaagag gagtcccagg acccgaggta ggttggtggc cagtccccat 27240 gccctccccc caacctgcca ggccaacaca cacccaagcc tcgtggttct gcccacggtg 27300 gacccacgta tcagtgggca gtggcctggg agagactcag ccacccagcc ttggccccag 27360 agtctcagcc tcatccttcc ttccccaggg tgagcccggc ccccctggag accccggtct 27420 cacggtaggt gtcacatggg gcagaaccag tgtccttctc ctgccaaaac tagacaccaa 27480 gagcagcagg ggtgggggaa ggtcagctgg cacggtcaga gagcaagatc agtggaggag 27540 gtcagagggc aaggtcagag agcaagcttg gttggggaag gtcacagggc aaggttggtg 27600 gggggaggag ggtggcagcg aggttggtag ggacaggacc cgccagcctc cccgcatggc 27660 tgcctccaca cgtgggctgg aatgtcccgg gacccccagg ccaggacctt gctgtggaaa 27720 ctcttctggg gccccggggg gactaccctg cctgccgtgt gcattgcagg agtgtgacgt 27780 catgacctac gtgagggaga cctgcgggtg ctgcggtgag gcactgccca cggcagggtc 27840 ggggcccatg caccgggtgg agggcgggag tgcagcaggg ctgggtcatc gctgggtcct 27900 gcatgtgcac gtgaccctag ggtctgaggt ctccccggta ccccccgatg accctgccac 27960 ccccccagac tgtgagaagc gctgtggcgc cctggacgtg gtcttcgtca tcgacagctc 28020 cgagagcatt gggtacacca acttcacact ggagaagaac ttcgtcatca acgtggtcaa 28080 caggctgggt gccatcgcta aggaccccaa gtccgagaca ggtcagcggg gcaggggcgg 28140 gtgcagcatt gcggggggcc gggcggggcg tgggaggcga tgagatggga gaagtccaga 28200 cgcgtccctc caacgagggc ctctgcatgg ctggggatgc cccagacccc gaggcctctg 28260 gcaacgacct cacgcgtgcg gcttgcaggg acgcgtgtgg gcgtggtgca gtacagccac 28320 gagggcacct ttgaggccat ccagctggac gacgaacgta tcgactccct gtcgagcttc 28380 aaggaggctg tcaagaacct cgagtggatt gcgggcggca cctggacacc ctcagccctc 28440 aagtttgcct acgaccgcct catcaaggag agccggcgcc agaagacacg tgtgtttgcg 28500 gtggtcatca cggacgggcg ccacgaccct cgggacgatg acctcaactt gcgggcgctg 28560 tgcgaccgcg acgtcacagt gacggccatc ggcatcgggg acatgttcca cgagaagcac 28620 gagagtgaaa acctctactc catcgcctgc gacaagccac agcaggtgcg caacatgacg 28680 ctgttctccg acctggtcgc tgagaagttc atcgatgaca tggaggacgt cctctgcccg 28740 ggtgagcgtg tgggcgcggg gcagtcggcc gaggagcagc aggccccagc cgctgtctag 28800 cgtgagcccc agggacaccc ctcacctgag ggatgaatgt gcagcccagg atcttgggct 28860 gtgggtggga aggggtcggg ccctctcggg gctgcagggc agaggccagc tgcaccctga 28920 Página 185 gcctgtctag gcagatcagt gaacggccgc tgagggttcg ctagggactg accctggcct 28980 ggcccggcct ctctcctctc ttccagaccc tcagatcgtg tgcccagacc ttccctgcca 29040 aacaggtaat gcagggcacc ctgagccacc accccagact agcaaagcag ccctggtgtc 29100 cttcctcctc gagggccggg ctgggggagg ggccgtgcag ggacccgggg ggcggcggag 29160 ccactgcgga ggctgctcct tagggagatg gccccaggat ggcagcacag gggaggaggg 29220 gcttggggaa ggcaggctcc caggaacgca ggaacagcat cacgaggcca tgaggtgggt 29280 gctgctagcc tggcgctgtg ctcggcatgt ggccactggt cttgaaggcc caccatgggc 29340 cttgcagtct ccctcagctg ccgcccagct cccatgggct ggccgtgcat gtgccactcg 29400 gaggaagccc tggattcagt gagtgaaacc atcccggggt ggaagcactg acacccccca 29460 gcaccagcag gtcttgctcc aaccctggcc tgcctcggag ctgcagctgc ggctctcaca 29520 tctctgggag tgggggagcc catgtcccgg atgtggccca cgtgggtgtg aagctggagc 29580 tgggggtgcc gtccaggctc tgctggacgt ggtgctgccc ccatggtgca ctgctgcacc 29640 gtacctgggc ccacaggagg tccccggggg cgttaggagc tgagtccccc tcagtgagcc 29700 gtcccctcca ggagtgtgag ggtagggatg ccatggagac agggtgggag ggtccgacct 29760 ggaggaccac agggaggaaa cctcagggtc tgcggtacga agtcagcgct tcctcagcac 29820 gcgggtcgcg gtgtgcgttc gggcgttcca tggggagctc ccggtgggtg agctgggcca 29880 ctgagcacat tcacaggccc tgaggctgcc ccaggggagg agccgtggac tcagagccga 29940 ggttccccat acgtgctgcg acagagaacc tagggcttgc acctgggtct ggctgccctt 30000 cagcaggcgg gcagcctctg gccccacaac agtgggctgt gcttctgccg ccaaggtgca 30060 ggcgtcctcc cccagggtcc acatcagcag caggggcacc tggaccctga gggcaggaac 30120 cagaccttgg ctcctccacc caccccctcg ttcctgatgg ggcagggaag tctcgggacc 30180 ccatgatggg cgacatggcg atggtcactg tgggtgcttt gctatcaggt ggggggcctt 30240 cctctccact ctgggtccag tgtgagtggc cgctatggct tcccctccac tccaggttct 30300 atcgtgagtg ggtgggtgct gcgtctgtgg atgtcacgtg acctttcctc tttagcctat 30360 cattgtagtt gggagttagt tagcccgttg agcgtcattg aatttccagt gttgagccag 30420 ccctgcgtgc ccgggataaa cccacctggc cgtggtgtgt ggccctgttt atgcacgtgg 30480 gccctgattc gctgatgcct gcctgagggt ttgcgcttat cggcgacatc agcctgcact 30540 tttcttttct cgtgatctct ctggttctgg cctcagggtg acgtgggcct cgtagggtcc 30600 tgtggtggct cctccccaga cggtgacatg gagtgagccc attctccctc ctgggagtgg 30660 gtcactcagg ccaccagagc accacaggga aagcagccag ggaggacacg gaggcccttg 30720 aagctctggc ctcttctgag gcctccagga cctgacagtg agtgggagca gccctggcag 30780 aacccctccc ctcctctcgg ccgccctgac acctcatccc cgacactcag agctcatcct 30840 ccttcccagc tgtttccaat ttcaaagtga actcgacctt gtggctccag gagatgcagc 30900 agggacagtg ttaaatcggc tttcaccagc ccacacggcc aggcatcctc ctcggccctc 30960 ctgggcactg ggtggacacc actggctgtg gcctggccct ggccttctcc agacagccct 31020 Página 186 gtccacccca aagcccagcc accctgggcc tgcagcaggc ctgtggagtt ctcagttgcg 31080 tggggaccag agggtgctgg agaaacaaac cagacgcagc tgaaggcagt cagggcaggg 31140 cgcaatcagc gataagagct gcataggggc cacagcgtaa cctgagctcc agtcggtgga 31200 aagaaaaggc agagacgttg cagaggccag gtctgctcag gggaagacag ttctgggtgt 31260 agaggactca catcccagag aggctgagga agggtttacc accgcaagct ttctcaggcg 31320 ggctcttgag gggtggctgg ggtcttcctg gcgacgggcc tgcggcactg gaagccctac 31380 tggagtttgg cctgtctccg gcacaggttt ggacggagct gttttgtgct gaaaggtttt 31440 ctcggggtcc gtggtgtccc ccaaaggtgc caccgtgcgg gtctcctagc tccctgccag 31500 cttcctgtcc ctgtgctcac tgcccccacg cctcctgcca aggccgagcc acacacccgc 31560 tccacctgca tttcctctac cgactcgcca gcccaaatgc cgctcttcac tctggcctcg 31620 ctgagcggct gcccgaggag gagctctagg ccgacgccca ccgcaggcct tacagtcttc 31680 tctggacgct cccttgcaga tgcaccgtgg cctggcggcg agcccccggt caccttcctc 31740 cgcacggaag aggggccgga cgccaccttc cccaggacca ttcccctgat ccaacagttg 31800 ctaaacgcca cggagctcac gcaggacccg gccgcctact cccagctggt ggccgtgctg 31860 gtctacaccg ccgagcgggc caagttcgcc accggggtag agcggcagga ctggatggag 31920 ctgttcattg acacctttaa gctggtgcac agggacatcg tgggggaccc cgagaccgcg 31980 ctggccctct gctaaagccc gggcacccgc ccagccgggc tgggccctcc ctgccacact 32040 agcttcccag ggctgccccc gacaggctgg ctctcagtgg aggccagaga tctggaatcg 32100 gggtcagcgg ggctacagtc cttccagggg ctctggggca gctcccagcc tcttcccatg 32160 ctggtggcca ccgtgtccct tgctgcggct gcatcttcca gtctctcctc cgtcttcctg 32220 tggccgctct ctttataaga accctggtca ttgaatttaa ggcccacccc aagtccagaa 32280 tgacctcgca agacccttaa ctcactcccg tctgcagagt ccttctttgc tgcatcaggt 32340 caccctcaca ggctccaggg tttgggtgtg gaagtctttg gaggccctta cttagcggcc 32400 cagctgggct gccgtgcgtc tgggatgggg ctgagggagg gtgctgccca ggtgctggag 32460 gatgttccag caccaggttc cagcggagcc tcggaaacag gccccagagg ctggtgagcc 32520 tcgctgggtg tgggcactaa tcccgtgcat ggtgactcgt gggcgctcac ggcccacctg 32580 gtggcaggtg aaggcttccg gttgggcagc agatagtcct gggggaagct ggcagtcctg 32640 gcaccatgac gtatctgggc tggtgtcatg cacagtaggg cgaatggcca cagctgcctg 32700 ccagcagccc tgatcccggg gtgtctgcac ccttccagcc caacctctgg gtctccaaaa 32760 gcacagtcgg gggagcatcc accaggcaca acctctgcgg tcctcagagg actgagcaga 32820 gaatcccagg gtccacaatg ttggggagcg gcagggatca ccatccaaag ggagcggccc 32880 ccacggcgag ctgaccccga cgttctgact gcaggagccc tcatccaggc tgggctcctg 32940 ccgggcacgg ctgtgaccat ttctcagggc caggttctcg tccccacacc cactgcacag 33000 ggcaggccag gctggtcttc ccactgtggg gatgaaggat cctccacagg aggaggagag 33060 cagagtccac agacatccca acagcctcag cctccctgtg cctggccggc ccccacagct 33120 Página 187 tccccgtctc ctccaggccc cacagacact gatgaatgga cagagacccc caaaaccagc 33180 tgccccttgc atgtctgtct ccatatgttt ggtgacagca gtgaaaatgt tattagtttt 33240 gagggggttt gggaagccca gcggtacctg aggagtttct ggacatttaa gccggttcct 33300 aggtgtggcc ttaacaggga ggctgccctt cctttcactg aatgagctgc gtcactcata 33360 agctcactga gggaacccca tctgccagct cgtgcgtgct cagacggcgt ccatgtctca 33420 agcgttctgt gaaggctgcg gtgcagcgtg aggtcaccct gctgtgttca gagctttgct 33480 cactgcctgc ggggctggac cgttgcacct ccagggcccc cagaaaccga gtttcgggtc 33540 agggtcctct gtgtgcattc ctgggggtcc atgtaccagc tgtgacgacg tccaggggtt 33600 gggctgagaa gcagacaccc ttggggaaac tggctctgtc cctcccctcc cccatcccag 33660 gagctgaggt cttggtgagg ccacagggcc aggtccacgc aaggactgtc cgtgtcctgt 33720 cctgtggtct ctggccccac gtgacaccca cacgtgtggt aggcagcctg gcctgggttg 33780 tggctatggc caggccccca agctgtcccc gatgcccagg gctggtgacc acccaggcag 33840 gtgggggccc cacttggtaa cagagtcata gggcagaacc cacctgggct gccacagaag 33900 gtctggctgc ccctgtgccc actgctcccc accatggcca atcagaagag tcaggggctc 33960 ctggtctttc cgggagggac gtggcccagc cagctctagg tgttctgagc agctctggga 34020 cccagcgatt gaggggtcag gctgggggtg tcagagccag ggtcctcctt aagtacctcc 34080 cacactacac agacagtggc ccttttgtgg gcagcaaatt cttgagccat gaaaggatgc 34140 tttgggcccc ttccctccca ggagggcagc ctgtgcaggg atggtgctca gcaggtggac 34200 agggcctggg gcctgtgtca gggtctcagg cctgggagca ccagcagagg agatggcggc 34260 tcccagcagt gccgcctgaa agtgtcttgg gctaaggacc cacacccagg gctgccctgc 34320 agaaacgccc ccgcagagcc cagtggtctg tgaggttgca ggcagggtgc gaatggaagg 34380 gcacaggtgc ggggctggca cctgcccggt cctgcccacc tcccctccgc ccagcccgca 34440 cctgcgtctc cccacagagc tgtccgtggc acagtgcacg cagcggcccg tggacatcgt 34500 cttcctgctg gacggctccg agcggctggg tgagcagaac ttccacaagg cccggcgctt 34560 cgtggagcag gtggcgcggc ggctgacgct ggcccggagg gacgacgacc ctctcaacgc 34620 acgcgtggcg ctgctgcagt ttggtggccc cggcgagcag caggtggcct tcccgctgag 34680 ccacaacctc acggccatcc acgaggcgct ggagaccaca caatacctga actccttctc 34740 gcacgtgggc gcaggcgtgg tgcacgccat caatgccatc gtgcgcagcc cgcgtggcgg 34800 ggcccggagg cacgcagagc tgtccttcgt gttcctcacg gacggcgtca cgggcaacga 34860 cagtctgcac gagtcggcgc actccatgcg caagcagaac gtggtaccca ccgtgctggc 34920 cttgggcagc gacgtggaca tggacgtgct caccacgctc agcctgggtg accgcgccgc 34980 cgtgttccac gagaaggact atgacagcct ggcgcaaccc ggcttcttcg accgcttcat 35040 ccgctggatc tgctagcgcc gccgcccggg ccccgcagtc gagggtcgtg agcccacccc 35100 gtccatggtg ctaagcgggc ccgggtccca cacggccagc accgctgctc actcggacga 35160 cgccctgggc ctgcacctct ccagctcctc ccacggggtc cccgtagccc cggcccccgc 35220 Página 188 ccagccccag gtctccccag gccctccgca ggctgcccgg cctccctccc cctgcagcca 35280 tcccaaggct cctgacctac ctggcccctg agctctggag caagccctga cccaataaag 35340 gctttgaacc cattgcgtgc ctgcttgcga gcttctgtgc gcaggagaga cctcaaaggt 35400 gtcttgtggc caggagggaa acactgcagc tgtcgctcgc ccaccagggt caatggctcc 35460 cccgggccca gccctgacct cctaggacat caactgcagg tgctggctga ccccgcctgt 35520 gcagacccca cagccttgat cagcaaactc tccctccagc cccagccagg cccaaagtgc 35580 tctaagaagt gtcaccatgg ctgagggtct tctgtgggtg gacgcatgat taacactaga 35640 cggggagaca gcaggtgctg agcctgttgt gttctgtgtg gagatctcag tgagtttttg 35700 ctgttcagac cccagggtcc ttcaggctca gctcaggagc cccacagtga accagaggct 35760 ccacaggcag gtgctgacct gacaggagtg ggcttggtgg ccatcacagg gcaccacaga 35820 cacagcttga acaactacca gtatcggcca caggcctgga ggcatcagcc gggccatgct 35880 tcctctggag ggctagagga ggactagaga agggcctgcc ccggcctctc cccagcatcc 35940 cagggttcct gat 35953 <210> 15 <211> 91573 <212> DNA <213> Homo sapiens <400> 15 aaatgggacc acaatttcac ctaataaaag aagacatctt tctatttaaa agggcttagg 60 gtgttgatgt ttgtgataaa ggagagaatg tatattgaag tgttttgaaa tgtgcaaagc 120 tttctagaaa cagaagttct tactcaagta ttttcccgaa gctttggcaa gataaccatt 180 tttattaccc cgtctgtgcc tagaatgggc ctataagcgc cacaatcaga atcattagat 240 atagaaatta agagaaatgt agcctccttt tttttgccgg tgaacagagc tttggttaac 300 agaaaaccaa ggcgatttta attgctggtt tttctatttg aagggggaag ttattagtag 360 aagtctcaat tcagaaactt caagaagaaa tgggagggtg tggtgagggt aagcggggga 420 ctgcatttcc tgttttcctt tcagatggtg ttggaaaaca ttgcaggaaa accatggata 480 cccacgaaga aattccaaaa tttattcttt ttgacgccaa gggcccagcc caaaaggtga 540 cgagtaggag tggtcaattt ttttttttaa gagttggggc ttgcaggagt ccagctaaac 600 gcttgtaggg tgaagacaga attcagaggg tgacatcagc ctgagcgggg gccagaagaa 660 acagagtgga ggagtctggt ttcatttaca gttttgggtc agttctgcag tgaggagggg 720 gagaggaggg gtccgggagg gaggaggagg aggaggagga gctggaggaa gccctgactg 780 gtatccctgg ccccagtcca gtttggagct cagtcttcca ccaaaggccg ttcagttctc 840 ctgggctcca gcctcctgca aggactgcaa gagttttcct ccgcagctct gagtctccac 900 ttttttggtg gagaaaggct gcaaaaagaa aaagagacgc agtgagtggg aaaagtatgc 960 atcctattca aacctaattg aatcgaggag cccagggaca cacgccttca ggtttgctca 1020 ggggtaagtg tgatttctct tctgtttttc caggtttggg gctagaagga aatgctctta 1080 Página 189

P201430887 ES 2 553 786 A1 09-06-2014 acctgaagtg atcctttcta ggtagcgtta gtggctctta cgttcatgct gatcgccagt 1140   tttctgtaca tgttttaggt ctctggaaga ttccgctgat ttttctttct cactttatgg 1200 caatgggatt tccttaaatt ggttaaggtc atgattgcct aagagtgtga gcacttttcc 1260 accgcgtgtc tgtggctgct acacgcgccc tgtgcattcc gggcggcagt gtgtttcggc 1320 ccatgattta tttaagttac tgccgccttc taaaacccat tcgggatccg ctttgtttgc 1380 agaagcgtct ttgctgagga ctagcatagc tccctgccgg gcggctccgc tgggagatgt 1440 tctctgagct ctctgggtgg tgacactagg tcagggtgca acaacctgca tgggttttct 1500 gcccagggcc gcccatggga aggtcctggt ggagcacatt tgctgctttc acaagattgg 1560 agtaactctg gtgctcagga tcagggccaa gtaaagggtc gctcagtcat tgccgtcaag 1620 ctttcgtctt tccaggaacc tgaagtctct attggagact ttgtcccttg gggttgctta 1680 aaggagttgc aggggtcaga ggagaagaag gaattgggca tttgggcagc atgctgagtg 1740 tctaaggcag ggcccctggg gctgcagggc cagcccatgc tgcacagagg tgaggccagt 1800 gccgagctgg gaggccccga gggctgttct ctggcccgga ggatgcaggg tggggctcgg 1860 gccctctctt gctgaggatg gacacgttcg ctgacagtgg ccagcctgtt tggggaacct 1920 gtttcaaggg gcctactatg ttggataatg aacgggtatt gaagtatggg tggggtcact 1980 gggagggact agggagtggt taaagaaaaa tctgcttcca caggaagccc caggagccag 2040 tttcgaggcc ggtgcagacc ccaggagcaa acccctctga gcacagggga gtctgctgtg 2100 ctggatgggg aggcagggct gtggccccgg ctgactggct tctctcccca catacagctc 2160 accccggcga ggaccacagg gtgctagagc tgcagggtgc tcagagctca cggggatggt 2220 ggatgctcaa cctgggatcc cccagctccc cagggtccca ttcttaatgc tgtaaaaaac 2280 aaccgaaatg gctttaaaat caaagttaca ttgctcctaa gcaaaactat attgaaaact 2340 gagtgggtgg ccgttgatga cattactggg acttctgagg tttttgttgg gctaaagata 2400 atggaagaga tttttggtca gaagccactg atgcagtagt ttcctggttt tcaaaatgag 2460 caaccagggg ctctgagatg cggaattcct tgcccaggcc agggagcgag tgcctgagat 2520 ggcagtgaaa tccttcccca ttgaaggaga gcagacaagc cagtgacgga ggatcccaaa 2580 taactcacat ctcgttggga aaactgcttt gggctcacta agactctacc aatgaaccga 2640 gaaagaaggg aggtggaccg tggggcgggg gcatcggttc cgtgaccgga ataccggggc 2700 tggccgccct gctcaggcca cctcctgggg gtggagggcg ctgaaggagg ggacctgtat 2760 gctcttcttt ctgaagtggg cttgtagctg aggatgaaag cctgggtggg gaggcgtggc 2820 ttttacaaag atcaggatgt aggaacagct gcctgtctgg acttctttgt ttagggggtt 2880 tcttgctacc cagaggttta gttctctcct ttcctcactc atggtcgaga gaagccagga 2940 agcagacact gagtggagca gagggcttgg gaaggaattc catgttgggg tgaagtgagg 3000 ctgtcctggc ttttcctatc caggcattgg agggtgtggc tacagcacct ttctgggagg 3060 tggctgggga agcctctaga atgttagccc ttggccccgc tctttccctg cttggcaggg 3120 agcgtgttcc accccactat agttgtggcc cacaggtgag gggacatgtg gcaaatgtcc 3180 Página 190

P201430887 ES 2 553 786 A1 09-06-2014 aaacctgggg tctgaatgat atttttgata cgaggtaggc acctttctga aaaattgtct 3240   ttacttcaca cttcatttta tttctaaagc attcaggact cagcaaattg cactgacttt 3300 atcatcagtg ccttttgtga tttcctatcc tagaacttaa tacgtccccg atgagaaagt 3360 aggaagaagc tcctctcttc agtcgattgt tgatttatgg ttccaatgag gctgctcatc 3420 ctgaccttag tttcaggaac ggaacccata gacctggatg cctaaagcca gcttgaaaca 3480 agaccgcctt ctttggaagc tttggaagct ggcagtgact ttttgccagc gaggtttcat 3540 ttgtttcctt gctcagagtg ttcagacaac tggatcaagc gtagtcttca ccagcggttg 3600 atatcacctc ccacttatat gtgaaattcc atgtttagga cttaaaattc accggcaagt 3660 cgtgaatact attgcgtgac acttccttgc aggcgcagta acagctttag caaaaatttt 3720 tatttgaaag ttcagttttg tcactgctct ttttggaaga agctgaaaat ctgctatctc 3780 ttgggggaag gattgcaggc ggtttccatc tgacagggat gttgtgtacc aggcagcttt 3840 tccaccctga cttacgggag caaacttttc atggtgtcct ggctgcagca agcaggcagt 3900 aaaaaacaca tcactgctac ataaatagct gacgatttga ggagggacct gacatttaaa 3960 gaaaatccta ttagctctag ctaagaaaat gaaagccgca aaccctccaa attttaaagt 4020 gggggagctt taaagtttcc tactaattca gacagccatg aactagacaa gaatggttat 4080 cttcattctc ccgtttctag atacagcttc tctgtttcca ctgtaaaact tcagtggaat 4140 tcagtgtaaa aattcagtgc aaagaaagga caatcctatt ctttaaataa aacatgttgc 4200 ttgccccctc taatgtgtgg tcatgaatgt cttatttcca gggagtattc cacaggtcct 4260 gattttgcag agatattccc ttcaacaatt cactttgtta attttgaaaa atataatttt 4320 taatacattc tggtcttata gtccattttg ggaaagagat gaaattttga gggctgggca 4380 ctgtggctca tctctgtaat cccagcactt tgggaggctg aggtgggcgg atcgcttgag 4440 cccaggagtt tgagacaagc ctgggcaaca tagggagacc ttgtctctac aaaagcgttt 4500 taaaaaatta accaggcatg gtggcatgtg cctgtaatct cagctacgag gctgagttgg 4560 gaggatcact tgagcctggg aggttgaggc tgcagtgagc cgtgactatg ccactgcact 4620 tcagcgcctg ggcgacagaa ccagaccctg tttcagaaaa aaaaaaaaaa aaaaagaaaa 4680 gaaattttga gttagcacgt tcatcctggt ctgtttttga aaaggcagtt tggttttctt 4740 tcctctagag ggaggtgtat ctctgcgagc ttcagaaaaa tctctgaagt ggtgcctgga 4800 gtctcccagg gtggagtttc agggtttgta gtaactcagt gatgaccatc tcagcagagc 4860 ttgcgggcag ttttaggact gatatttcaa tacatgattg tcattattat atttattgtg 4920 gctgttcata ataacggaag tgtacatacg ttagagcttt gtttttcttc tctgctcagg 4980 tgtaagtgta ttgagatgaa attgtgccat caaaggaggc atctttgttc ccaaacaatt 5040 gcattacaag ggtattcagc aaataagaca ttttatagga agcattttac ccatatctaa 5100 ttacagaggt ttaaatgaac agtcgggtgc ttgagaacca aagtaggttt gcatattcat 5160 gccattgcgt atccctgtag aattaccgga ttttagaact gtaagggtgc tcgtgacatg 5220 tcctttgata ctttccccta ataatggaca atgggtttta acatactttt aaaaattcac 5280 Página 191

P201430887 ES 2 553 786 A1 09-06-2014 acaagctatg attatgaatg tctcgtcttg aatatttatt aatacaaata tatattactg 5340   actctcagat ttatgtctgt tcgcttgaga taaccagcat taagactctg agggagacaa 5400 ttctagctca gagcaaaaca aacaaacaaa caaacaaaca aaaaaaacaa aaacctaacc 5460 ctttggttgg tctttgtgtt ctcatgttta cttaagttta acaagaccta ttgtgcatca 5520 tggccttgag ccctgaggtt cagggagggg atatatccct aatgctaaat gacgagttga 5580 tgggtccagc acaccaacat ggcacatgta tacatatgta acaaacctgc atgttgtgca 5640 catgtaccct aaaacttaaa gtataataat aataaaataa taaaaaaaga gaatacattc 5700 ttggggaata ttaaaaaaat gactaagaca tagccccctc tcttctggtt ggcaaacata 5760 taatttctgt ttggctaatt gaaatatcaa aaaaactact accttggtgg atggtttctc 5820 cacgcccttt atgcttcaga tgaagaaaga gagctcagag aggtatgccc agtgacaggg 5880 ccacagagct agtagcagaa ttgtctgatg tttccaatat gcagacatct tggaatctgg 5940 acatttcaag ggggacaagc ctttaagagt gtattttagg gtgccatgtg gagaaaggta 6000 ctcttcccat tcccagtctt ccttggagta gcctctttta agttgattca gcagaggagt 6060 aactgttgct taaaaaaatc tggaaagaaa aaggagagaa gaaaaaaaca aatacgaaaa 6120 gttctgccaa accttctccc aaaggcaaat tgttagtctt gtaggggtct ggctgcattc 6180 agcatagtat gatcctactg ttctcctgaa gtttaaactc atgaattaca gagaaacatt 6240 tgagaattgc aagtggccag ggaaaagtac aatgggaaat gtttctgtaa aaccccctgt 6300 gtgtgctata cattaggttt tcaggaaccc agagcatcag gaattggtca ctggaaggaa 6360 gagctcatgg ctcggtttaa tttcaaaatt aaaaattgaa cagcagctgg agttgactca 6420 gatctcaagg gaaaccattc caggaaactg gtttttcact tctggaatct tcattagttg 6480 attcagcagc ccagggccgg tacccagagt tagcgccaac tcagctaaac ccacagccgg 6540 cccggcggtg caccagggtg ctctgtttct aactggggct gcagaaaacc catcattcat 6600 cagagcccag ggcaacagat ggaagagagc agtcgcagga ctatggcctg ttcgagcaac 6660 aggcaaggag ccttctttta cacaaaaggg aggctgggag agattggccg accattgctg 6720 acagaggcag taaggaagta gaatttccca ggttactgca ataaatccag catggatgat 6780 attttatcag atgttccaac ttgatttttg aaaaggtttc tgttttcaag aatgatttta 6840 tcttctctac ttgattataa attagactag aaaacagaca aaatatctaa cttttctctt 6900 tacaaagaga gcacctttca gccactttaa tcatttacag tggaacacca cagttttgga 6960 aaggtcagta gcaccttagt tcattgccaa gaaggaaaag acaggaataa gtgccaagct 7020 ccaatttgga tccagcagcg tcacgtggca aggagttgga atggagtggg catttgtgca 7080 atatttcttg aagcattttc taatgcacct ttcttcttta atgttgaaat ggaactagtc 7140 tctgcctgat gtttataatt agcagtataa gtgcagacaa aatcttgtct ggctgccgta 7200 tatttcagaa tgtggaatgt gttttacatt tgcatggtgg cgtctagctt ttcaaatcac 7260 accagatatg gaactttctg cctcatggtt attatctgca atgctaggaa tatgttttaa 7320 agtaattttt tcaaatatct gggtaattaa tctggagttt cttaattgcc tttgtaatgg 7380 Página 192

P201430887 ES 2 553 786 A1 09-06-2014 gaaggagacc cacctctgag gagcttggcc taagcctggc tgcaggtcgg catattctta 7440   caggtgctct cattcacaga gggagggcat tggtagggga tgtccaggcc ttctctttct 7500 gcattgcttt gttataatcc acaagttgca gaacaggtgt tgctttgtta gattttacca 7560 ggaagagttg aagatctcga atccgctact ccatatctaa caaggacccc cgtaagtgac 7620 aaaggacccc agtaggtgac aaaggaggtc tagttaccct gcctgatgag aagagtttta 7680 aaatgttgct atcacaggat acacattcag tttgagtcaa acagattatt gttctagagt 7740 attttcatag aatagaaatt caaaggccag gtgtagtggc tcatgcctat aatcccagca 7800 cattgggagg ccagggcagg aggatccctt gagcccaaga gtttgagacc agcctgggca 7860 atatagtgag atattgtctc taccaaaatt caaaaaaaat tagccaggcg tggtggcgca 7920 cacctgtagt cctagctact tgggaggctg aggtgggagg attgcttgat ctcaggaagt 7980 tgaagctgca gtaagctctg atcatgccac tgcattccaa cctggacaac agagctatac 8040 tctgtctcaa aaaaaaaaaa aaaaaaaagg gaaaaaagaa agaaatgtga aatccaagtt 8100 gttaaataaa cagtaaaaaa acaaaatttg ctatatttct ttggaggttt cttggagctc 8160 ttccaaaaca ttttcttttg aggattctcc tttgggtctt tcaaacacca agagcatatt 8220 aaattccact ctcctcctac cctaattgca ggacttaata aatcctttct tagcttcctc 8280 cctgaggaaa agaacgggga ctcctttccc aggattcgtg caaaaagaga gagaaagagt 8340 gagaaaaaga gaaagaaatg gggcgctcct tcttgcagtc taggaatggg cgtggcaaag 8400 gcaagggtgg atgagtgcct caaatttact gaaatttgac tttctatttc acagtcagtg 8460 tgcacggctc tcccactgtg gtctttgact atttccactg ctcccatttt aaacaggaca 8520 attaggaact aacagaagtc ccagaacttg ataggaggga caggctgatt ttaaaaagca 8580 gtgcttggag aaaaccaaat aaatgacttc aaaatggaag ctctggattt atttgagtct 8640 ttgttttcaa actatttcct tgtgtgcatg cgtgtgtgtc tctttcttaa aaaagatttc 8700 cagacatgga aaatgaaaaa ggttttgagt aggctaaatg aaaactaatt tacagaattg 8760 caaaatagct tgggaaatca tattcattgg aatatgattg aatatgattt caggttgaag 8820 ggccatgtag ggcaatcttt ctgatgaaag gtatcctttt aaatttcaaa gggatagaaa 8880 ctaaacggaa aaaggcacct caaatccttt ttagaatgag gcagagtaaa caaaaagatg 8940 aataatccta aacagaaaga tgagaatgaa aatgtgatga atgtctctta ttgaatctgt 9000 ttcctttagg acacagaatc taggatgaag gaacagaccc cttccagccc aaggatctca 9060 agcagccaat tctgagtctt tttttcatat ttgaaagaat gatagtagac agccgacttc 9120 cattgacata gaatctgtgg tgtgtcacca ccaaggaagt ctattttttc cccaaaaggc 9180 atggggagtt tccttgagat ctgggccaaa tctggcacag cctctagggt ttcccggggt 9240 tcttcccatg agctttggaa atgctaactt gggttagggt tctggttcta tgttgttttt 9300 atctatgtag ctttgaacaa tcactttgcc ttgctggggt ttcaatttct cagctataaa 9360 atggagggaa atcagccatc ggatggttgg gaggagggcg tgaaatccca cccacaagac 9420 agaagcccag gaaacgttac cagcactctc ctctctcctt cctccgggag ggtggtgtcg 9480 Página 193

P201430887 ES 2 553 786 A1 09-06-2014 gggaatgagc gcggatggct gcctcattcc ctcttgttga agagggcggg tggtcatctg 9540   gtgagatggt gtttgacatc ttttaataat ctaaatgaaa aagttctcca aaatttgctg 9600 ccagggaatt tcgttttttt ataaatggag actccaggac atgacaaaca atagaagaga 9660 gttaattgca aacgaaaata tcagcaaata ttcaacagct gggctaggag cccacgagcc 9720 acaagacctg cttcccgcat gatggcagga aagtgtgtgg ggccaaaggc gtttttccca 9780 cctgggaatt cagctcagtc aaaccatatg ggttctgaat catcagtgga gcctggataa 9840 cgcattgtcc tacaggcatt atctcccgtc cttttcagag ctggaagggc tcctttcctt 9900 ctcttccctc ccctcctctt ccctcaatat ctggatatat tctggataaa ataattcctg 9960 tgcacagtgt atttatccca ttactttgtg ttccaatggg aagtatctcc actgaggggg 10020 ctactcctcc aaagattcac atcttgaaaa taaaaatctt tacatatgat tttcaatgaa 10080 ctaaaagttc attttactca gaatggttga agtaagtgag tgatgtctta gacttcccgg 10140 attttatttt gtaactattt agattgtatt gagcactctg gaagatgaga aatgtaattt 10200 tggaattgct ccagagtgag cccactcaat gctttatatg tgacagaatc agtggattca 10260 aaggctttca ctgtgtgagg tatgggaatg attaagaaaa ccattagcaa aacctgctca 10320 aggcataatt cacttgtgct ctttgtcaat gctccctgca caggtgtctg cagctcttcc 10380 catcccagac tcaacagtga ggagacagct ctcatcttat catgtcctat tttttccacc 10440 tggattacaa agccgaatgc tttacaaaga gcctctataa tactcttgtg ttctcattca 10500 caaacaaaaa taccacttaa aatcatgcct cttgaacatg gattaaacat ttaaagtaat 10560 cgaactggat cttccagaag atttgcatta aaatttttaa ttgaagcagt gatgcttaaa 10620 cttttggggg gtgaggagtg gcacaactgc cttttagaat cacatacaaa catggaccct 10680 tatctccaga aaaaccctca tccatagatg caattttgca ctcaactgtg ggaggatcat 10740 agactctttg aatctgttga tcccgtatta aaacattgat ctggaccagt tacaataata 10800 caggttgttt tggaaagaac aggccatttt cttagaaaga atctagcagg aagcttacct 10860 ttgctaaaaa aaaattgacg ctcaagcttg atagaacgaa tcaagaatag cacatataaa 10920 atgtactttt atattattct gaagtgtata tcattattta attgaggtca tacaaaaaat 10980 tagatattgc aattgctttt tttttttatt tgaagaaaca ctcaggaatg ggtctaacag 11040 actgtaggga agaaaggtag agcttggtgg aaaagtctgg aaggttccca gggttgcatg 11100 ggcttgaggg attcctagag agtgaagggg caaagttggg gctgtggcac ggtgggggta 11160 gggtcaacct aagtggaggg aggagaacag gcagtccagc ctgtcggggg tccctgagcc 11220 ctgctgtgct gcgaccgggc taaagcttgg gagcattatc aaaccacagc acaagcactg 11280 gagactgctc ttctacattg tgttaacata tatccatgtc caaaaggcag tgaccattgc 11340 aagggaaaaa aaatcgggct gagcttttgc aatactgccg ctatcaccac tcattgctgt 11400 cactttgttg cagaaaaata tctgttctgt tgataactgg cctcctgagc atcattagaa 11460 cagcattcct ttctcactgt tgatgcattt ccaagagact gctgtattga caggtggttc 11520 tattttagct gctgagatca tggcttcaag ttctcagaat ctgaatcaca gggtacattt 11580 Página 194

P201430887 ES 2 553 786 A1 09-06-2014 gtttcatcac aggtggtact ttttgttgac tttctttgga aatccaaagc cacatgggtc 11640   ctggtgttca ttcccttgtt tgtggcttca tctgtctcca tctcaccaat ttttggcggg 11700 tcaggcctag ggcccacact gtgttccgtc ttcctcatag ctgggccgca agatttggac 11760 tccagcttct ccctctgggc ctgacctcag gcaggaggaa tttcacggca aatccacggg 11820 actgagcttc aggtttcctt tgcacccact tagctcctgt ccttgactgg cagcctcaat 11880 cactctctgt ggctctccct gtacctttgc taagtggtcc atctggacac tagtctgctg 11940 ctccattcat ggcaaagtta catcactcat cagccggaca gactctcctc tgctatcaat 12000 cttcaggtgg caaggctgag aacattagat catcctcatc cctgatttca ttagctgtat 12060 ggggaaaatg gaattcctgt gctacacaac agacaaccat gaagacttgc agagcccatg 12120 ggggcacctg tggagagagg aagattaaga tagagataca aaagctcagg ccttgggtgg 12180 agccgattcc aaagctcaga ggatactagt caaggcagaa gccatgtttg caccaggtct 12240 gaatgttcat attagattct ttcccacttt catgagactc tgatcttctt tgccaaaccc 12300 taacattttg catgacatat actcttttct tatttctttc caaatcttat ttagaagtaa 12360 gggcaaacat tgtgttattt gaatacagcg gcatgtagac acactttagg atgtttagtt 12420 gtactgtttt ttcctagtag ctcttaaact ctatcacacc tcaaaaaaga gatgctgcac 12480 ttacatcatt cctgttaaat tgatggctac attttagggg tagttaccca tgcttttaaa 12540 acctggcaaa tgatatttcc tgtcctcatt tctattttaa ttgtggtaaa aaccatataa 12600 cataaaacat actatcttga ctatatttaa gtgtacagta cagcagtgtt aactatacgc 12660 accttgtgct acaacaaata tctataactt tttgatcttg caaaacagaa gctctatacc 12720 tatgggacag taactacaac tgcctccctc ctgacagccc atggccaaca ccattctagg 12780 ttctttttct aagactttga ctactttaaa taccttcaca taaatggaat tataaagtaa 12840 tgcatttgtc ttttagtgac tggcttattt cacttagcat aatatcctca agattcatcc 12900 atgttgtagt agataaaagg atttcattct tttataaagc tgaataatat tccttgtatg 12960 tggcatgtat aagacttagt ataatacagt aggccgtgca cagtggctca cgcctgtaat 13020 cccagcactt aggaaggcta aggtggaagg atctcttgag cccaggagtt caagaccagc 13080 ctgggcaaca tggcaaaacc ctgtctctac taaaaataca aagcttagct gggtggggtg 13140 gtgtgtgcct gcagtcccat ttactcagga ggctgagaag gaaggattgc ttgggcctgg 13200 gaggttgagg ctgcagtgag ctgtgatcgt gacactgcac tccagtctgg gtgacagagg 13260 gagaccctgt ctcaaaaaaa aaaaattaca gtataagtgg tgtaataaca gtgcaaagtc 13320 ctaggagaac tgtaggaata gcagttaatg aatttaacaa atatttatta tacacctaca 13380 atgatacaga caggcatttt gccatactct gtgctcagag tgtggctgag cttcacagtc 13440 ctggaagact ctttgtttat gataaagcag ccttggaaat ctataatcaa tttcataatt 13500 gcaaaaaatt ccattgtgtg tgtatatata catatatata cttaaccaag gaagaaaaaa 13560 acctgtgcac taaaaactat aaaacactgt tgaaatgaat taatttcttt attcatctca 13620 tctattgatg gacttttaag ttgtttccat cttttggata ttacaaataa tgctgaaatg 13680 Página 195

P201430887 ES 2 553 786 A1 09-06-2014 aacatgggtg tgcacatata tctttgagat cctgttttca cttcttttgg atatacccaa 13740   aagtgggata gatgaattat atgataattc tgttttcagt tttttgagga acattcatac 13800 gatggaggct agcctttccc cactgtgtag ctttgttgaa gctcaaagat catatacatg 13860 aggttttatt tctgggctct ctattctgtt ccattggttc atatgtctgt ctttaagtca 13920 gcatcatatt gatttcatta caccattttg taatatgttt tgaaattata agtgtgaggt 13980 ctcaagcttt gctattttcc accccttcat tctgttaatg tggtgtatca cattgattgg 14040 ttttcatacg ttgaaacatc cttgcattct agaaataagt tccacttggt tagagtgtat 14100 aatcctttta atgtgctgtt gatttggtca gctagtattg tgttgagaat ttttgcatca 14160 gtgttcatca gggatattgg tctgtatttt tcttttcaat attggcctta taaaaatgag 14220 tttgggggtg ttcctttgtc tttaattttt ttgagaaaag tttgagaagg attagtgtta 14280 attcttcctt aagtgtttgg aagaattttc caggagagac atctggtcct gggttttttg 14340 tttttttttt atggaaggtt tttgattacc gattcaaccc catactaatt ttaagtctgt 14400 tcagaatttt ttttattgct tcatgattca gtcttggtgg attgtatatt tcaagcaaat 14460 atctattttt tttctaggtt atccagtttc ttggtgtgct attttcctca cttcttacag 14520 atctcatgta gtcttgtcag tctttccaaa gtcttgtata aacaatttca cgtgcctgat 14580 ttgctctcat ttccccttgc tttcttcagg gaattgccaa attattcctg atgcagggga 14640 tataaaacca atctgtaagc atttggagtt ttagaattat aagatgaaaa aagtcacatt 14700 tcaaaatctg acatatactt gatacccaga aagatgtttt tgattttcat tcacactgat 14760 gctgaatgcc tttacatgct gtaatctgtg aaacagactt ctttttaacc ttcaaaccct 14820 aacagtgaaa tgatgatgaa aactcaatct ccctagatta tatgtatttc agtttcttaa 14880 gtcaaatgga atttctaatt taactgtagt ctacactata tcatttccaa tatcaaataa 14940 ttcttcctga aactcaatat aagaaaaaat gacaatatta actagtgtca tgaaagttca 15000 tgctgataat gagattgagt ctggtccttc ccctgggctt ctccggggaa atgtcagtcg 15060 tctacccatt ctaattctct cacttggtca cagggaggca gtgagctcca ccatcaaggg 15120 acatgggtcc cacttacagt taatggagtc cgagagagca gatatttgca aacccagtga 15180 tctgggctca gtggaggcct gggcaggtgg agatgccttt ggttgctgct tcagaggagt 15240 aagagcttag caaaattaga catggagagg aatagcccat gaaatgtgtt tggggaattc 15300 tgggttaaat caagtacagc aggtttcttt actttatttt tcagaactgc tatatattaa 15360 ggtatattgt aactgttcca gaaggaggct tggtattcag cactttccaa actgcgttgc 15420 tcatggaatg cctgtttttc cccttagaac atcgaatgga atgggtgttc catgaaatgt 15480 gctttgggaa atgctgatga atgaaacgtt gctggagaat ggtagttaga gttcacttac 15540 catccattcc gcgtcaggca tttaccaaac aggctaccac atgctcctca cagagggctg 15600 gaagagaggc atggctatca ttgttctgtg ttatagagga ggaaatggag gctttgagca 15660 agtataccac ctgcctgagg tagggtatgg tggatccagg atccagattt atctgattcc 15720 aagcaccttg tctttcccca acatctctgg ctccttttct gattcctaaa aagcccaaat 15780 Página 196

P201430887 ES 2 553 786 A1 09-06-2014 tcaggctggt gaacttgatt gaaaagttgc tatggaatcg tggggttttc atggagaaat 15840   aaaaatgttc ttcttatcct ctcatcttat gaaccctcag tgtggcaggt gctattgagc 15900 accaaggtgt ctgaatagtt gtgcaccttg gccacttatt ctctgcaccc ccattttttc 15960 ctgtaagcat gaggatcagc atctacctct aaggataatg taaagataaa taacacacat 16020 tatgaaaaat tatgaaaaac tgcaatgatc acatagtaga tgctgaataa cttttgataa 16080 catggcaccc aaaacagcgg tttaataaca tcctagccta cctgtgtcgc caatggcctt 16140 gttccccagt actgttaccc aaacctctga aaagggaacc cctgaccaga gagctcctaa 16200 ctggggaacc cctggccagt ctgggtaaga agagtcactg acatgcacat cattgcaaaa 16260 tgaaaatgag cttctcgttc aaatgtttta agaattccaa gatagcaaca tcaaagcatc 16320 aaactgagca tggggccctt cagagcacag ggtcctgtgg gcagccccgt ctgtggtcta 16380 agaaaaagtt aaaggaaacc agaatcctgc attaaggaga ggagaaaaaa gatgctgtcc 16440 tggcaagggg acttcagcct agacagaaag accctagctc tctggagggg tcttaaggga 16500 gaccccagcc cccaagctga tctcttagat tggagattgg agagtgaaga ggctgtcaca 16560 agatcttgtg gtaggaagaa aaggtgttgg caggggaaag gtctgatggc gcacgctact 16620 gagctgaagt gaatgtgaac ttggctggtg gggcatcatg tgtgcggccc ccagaggcgc 16680 gtgggtatgg gagactctgc atcagggcag ttagcctcca ggtctggctt cacagtctta 16740 ctaattaaat caccccaggc tcattccact gtgagattgg aggttggcat atggcagatt 16800 ttccttggag gaaaagtgct aaatattaat agagaatatg gacaaggctt gacatggtcc 16860 cagctgctgt ggttgggttg catttggtgt aatttgggca aagcccgttc tctccataaa 16920 ctgaaacttt cctctgaggt tcttttaaac atgacttaca aacttaagct gggtgtcaaa 16980 acctgatgcc ttgtgcctat gagtgctttt actcctgacc catttccatt ctgctctttg 17040 cttaggaata tgctatttcc aaattgctgc gtacatcact tagggaggaa aagaaggttt 17100 aattgcatag ctttttagct gtggccaaag taatagtcac tagattcaaa aattctcatt 17160 tatatgttta atcaaaacta tctttcataa tggataaatt tttcattcat tagtaatttg 17220 aaaaagaaag agaatatttt cagattgtgg agaaactact atgaatgcct attttctaaa 17280 aatgtaattg tgttctttga actatgttta agaatgtcca gagaggagag tgagcagtgc 17340 cattacaggt gacctatgtt ctgctaacaa gaagaggtct gaggtccctt tagacagaga 17400 gctctgccta ttcacttctc acttacctat tctttacctt cctcccacct tcccaccttg 17460 cctcctccct tcctccctcc ctccttccct ctctccctcc ctccctccct ctctctcttt 17520 ctttctctct ttctttcttt ccttctctct ttctttcttt ccttctctcc tctttgtttt 17580 tcttctgctt ctttctcttc ttctccttcc ttccttccat ccttccttcc ttccctcctt 17640 ccctccctct cgccttcctt tctttccctt cctttccttc cttcacttct tccttccttc 17700 ccttctttca cttcttcctt ccttcccttc ccttccttca cttcttcctt ccttcccttc 17760 tttcacttct tccttccttc ccttccctta ccttccttct cttctccctt cccttccctt 17820 ctcttccctt cccttctcct tccttccttc cctccctccc tccttccttc cttttatata 17880 Página 197

P201430887 ES 2 553 786 A1 09-06-2014 tgcatatatg tgcgcatgta tgtatctgta tagattttta tctatctatc tatctatcta 17940   tctatctatc tatctatcat ctatctaact gtctatcatc catccttttg ctgctggttc 18000 aaagaatgaa tcagatacaa agtcttcttg gaagtctaaa aaggacgtag aaagcatggg 18060 attttgagag attttgcata atgagagtca aaaactgatc attccctttg ccctgttttc 18120 tcttttaggt tcatatttgg tgcttagaca aattcaaaat gaggaaacat cggcacttgc 18180 ccttagtggc cgtcttttgc ctctttctct caggctttcc tacaactcat gcccagcagc 18240 agcaagcagg taagagccag aaacgtcctt gattttgtaa aaaggaatat cattctttga 18300 ttttagatct tagacatcag gcactgacat agagcttaga tatgttctta aggtagctaa 18360 gccatttatt ataggatagt cagataggat agttctagga tttataggcc ttttcagata 18420 ctctttatcc agtgagagat gacctatttt tattaaaact tgggtttggt atcttggaat 18480 tggcttgaaa atgatttgtt tttacattgg atgtgaacgg aaagtttgta tctcaaatgt 18540 tttaccacct gaagggactt tccacatttc tggcattggc tggtctctga gcacataaag 18600 tagggagaag tcaatgattg agagtaaaaa ctattttccc tgaaaaatac aaagatcacc 18660 ctctctctct aactccagat gcaggaaggc atttttcatc taggatcctt gaatctttaa 18720 gatttctgtt tcccaaaacg aattaaaagc atgggttcta attaactcta ttaagaattt 18780 gatttcagag ttttagaaaa gtgggaaatg cttcatgcat tgcaagctgg aaaggactca 18840 ggtgggtctc cctctccttg acccagagag cttggcctct gagggattct tcctccaggc 18900 caggttgctc ttagatggag ggaagtctag tgtcacttca atggaagaag aacgtgggtt 18960 ggggcatcag gtcagcctga ggtaagtaga gtccagcagc aagcctggct cacagctgca 19020 gaagggcacc tcctggggcc actgacagcc tgataccctg agctcccacc cttgagggag 19080 aactgggttc atctggaaat gagatagata atgtttgaca tctatggaga cttttctggc 19140 tctgaaaaat atgcagtaac taatagagta cagtttgttc atgctcaaaa aatctggaaa 19200 aaataagtct tttcccttct ctacatttac acaagtcctc ctcgcttaaa gaacatgtat 19260 ttattatatt tatttttcac gcaaattacc caaagcattg ggggttagtg aatggaaaat 19320 agcaattttt acttttcctt ttttgtcaag gcccggtttt gtattccaaa ctaaagaatg 19380 aatttataaa atgatggttg gttgtctgtg ataagacttc cttctggttt aatcaggtgg 19440 gtcttggggc tcaaactgcc acagggaatc atacttgagt taaagacagc ccaggaaatt 19500 gtttccccaa tctggagcat gctactggcc cattcatgat ggtctctgag tatggaactt 19560 gggctagtga ctgggcacca gcagctattg agtgcatggg ctcaggtccc tggttcccag 19620 gtaagtgagt ctaccttcct gtattatcag tgaggtgtga agtgtttagt agcagtatag 19680 tgtaaaccaa atttgtttag gaaggctttg cattgatagg aagtaattgc ttacatagta 19740 gaaaaatcta aaccaatgtc tttttttaaa gatgtcaaaa atggtgcggc tgctgatata 19800 atatttctag tggattcctc ttggaccatt ggagaggaac atttccaact tgttcgagag 19860 tttctatatg atgttgtaaa atccttagct gtgggagaaa atgatttcca ttttgctctg 19920 gtccagttca acggaaaccc acataccgag ttcctgttaa atacgtatcg tactaaacaa 19980 Página 198

P201430887 ES 2 553 786 A1 09-06-2014 gaagtccttt ctcatatttc caacatgtct tatattgggg gaaccaatca gactggaaaa 20040   ggattagaat acataatgca aagccacctc accaaggctg ctggaagccg ggccggtgac 20100 ggagtccctc aggttatcgt agtgttaact gatggacact cgaaggatgg ccttgctctg 20160 ccctcagcgg aacttaagtc tgctgatgtt aacgtgtttg caattggagt tgaggatgca 20220 gatgaaggag cgttaaaaga aatagcaagt gaaccgctca atatgcatat gttcaaccta 20280 gagaatttta cctcacttca tgacatagta ggaaacttag tgtcctgtgt gcattcatcc 20340 gtgagtccag aaagggctgg ggacacggaa acccttaaag acatcacagg taatggcaac 20400 gccaccaagc tacgccctgc cctgctgttc ttgggagatg agcttggcaa ctgctggcct 20460 taaagcaaca gctaggatgg cgggtgggcc agggaagaga tgagtgttca caggtttaaa 20520 aacaaaggtt tgatttggaa tattcttcca tagtcttctc cccaagtagg gcattcacct 20580 acatacaaga agagtctttt tttaaacaac taatattttc agtctaaaaa aacccacatt 20640 ctaatattat gatcccacaa aatacctctg ccttccttag aaaagaaagc ctcagagtgg 20700 tgaggtgtgc atctgatcaa actcctctat ttggtgttgg gatctgtttc ctttaaggaa 20760 agctccctgt tggagagtgc gtgaactgag acgggagcga gggcatctgt ttttgtgtcc 20820 agtggactag cagagagctt ctctcttcta ctttacggag ttaatttaag agtgttggta 20880 gaatcggaat tacaagaaac ctcagctatg atccagtcta gattgatttt ggaaaaaatt 20940 tagtcctgaa tggttagtga cagccggagc tggaggctgt gcatttgggc tgtgggtctg 21000 gtcttcttat ttcttctcca tgcggtaatc atggctgtgc ccacagagac tcttctaatt 21060 ctaatggagt tgatgagaac cactctggaa gtattgagag cacacggaca ttgcatcgat 21120 gtgtcatgtg cagttgcatg tacagagcta attggccgac aggttattta accagttaag 21180 cctgttagct ctccttccag ggctaagtgc ctaaatggcc aatggggaag gaatttgaca 21240 agtacaattt caaactctac cataccacag caactgtaat gagtgcccag agcttactca 21300 tcagcgatgg gcagagcaga gggacctccc cttgttagaa aatgagtcca tgcagccatt 21360 tgatagttgg tagcagagaa ttctgggtgg aatgagcagg aaatgagaga ggaatccagg 21420 gggagagttg agctccagaa aggagacaca catgttctct gagatggagg gaaggcatga 21480 gaaaaggggc tgtgtttcca agatattcag gtggataaga ggcacattga gagagttcaa 21540 gttgagttga catccatcat ctcaataaag gagggaagca gtggggcttg ggggcttgga 21600 gggattgaag ttatttttga tcagctgcta tagggatgtg aagaggggtc acaaaacatt 21660 caggaagcaa ctgctgattt gaagtggcat ccagttgcta tcagagatta caagtcagtg 21720 ggtgtctcca ttagtgtgga tccctgcctt tctgcagata tctcaggcac tcccaggatc 21780 aaaggagttc ccagaactgg aacttgcaaa gagggaacaa tagagaggac agaagaaaat 21840 tttctcagta aggaaatcca gagtggtagc tagtaaattc ctgaaacagc ctgccatggt 21900 gtcctagctg catggggagc taatgagagc tggaatgggc caggagacct ctgaagagcc 21960 agaggatgag aggccaggtc tcggaaggag agtcctggag acagctgagt gtgcaagttg 22020 gagacgctgc tggtgtgtag acagggagac ctctgagggc caatcgcggg gctggaggag 22080 Página 199

P201430887 ES 2 553 786 A1 09-06-2014 tttccaatgg tgctcagtgt ggtcctcaga tgtgtaggaa ctatagagag ccagccactg 22140   cagaaaccag agagggtggt gctcacaaag gttgtccata cagaccttaa agtctggaga 22200 tgaccacaga gtctgcagtg tgaacgcagg ctgaacataa tgtaactaaa tcatgtagga 22260 atgttggaga ctctcttctg tgtatttagt aggcatgagg aagtggataa ttctttgaat 22320 caaaaaagaa tgagtgggca accacatggc ataggggaac tgatcatagg aagcaagatt 22380 tatgaacaga tttttctcct acacttttaa aaatggttac caccaagatg gccactggga 22440 caggaggtag gaggtgaggt gactgatgga gagtcagtct cttgtgaata cacatggatg 22500 gtggggcagg aaaaagagag ttgaggcttg gaggcacaca tcactctaca ggaccacatc 22560 ggagggacag cagaagaatt gcaagattgc aatcagaatg ctggagcagt tgcagagaag 22620 cagtaccaga tgtcagtttt tcataacaag gattcagaaa gcaggagctg aagagagatg 22680 acccaacatc agcagaaagg aactagctgt cttgagcagg cagaacttga tgaagaagag 22740 ggtttcagaa ctagccagct ccagggtgtt tcagaagttt gttcataaaa tggttttccc 22800 agtggttact cctgatttca gctttaacgg ggctggcagt gctgatgccc ttacctgtgg 22860 gtctgcttct ccataggaaa gagtgagagg cagttcaaac actgcaaagt gttccctgct 22920 tccaaatgac aggcctcacc cctggcatta ccacacaggc atcagtcctg ccaaatgaca 22980 ggaaaagctg ggtgtctcca agagcacccc aaaccaaaca ctcaggttac caggaaatga 23040 caagagggta tctacaatga actgcactcc tcgctacgat agtctcagta tcattaattc 23100 cctgatccat cacatttcgg aatatcggga taataacaaa gacctaccaa aaaatagtga 23160 aaggggctca cgcctataat cccagcactt tgggaggctg agacgggagg atcatctgag 23220 gtcaggagtt tgagaccagc ctggtcaaca tggtgaaacc ccgtctctac caaaaataca 23280 aaaattagcc aggtgtggtg gtgggcgtct gtaatcccgg gaggctgagg caggagaatc 23340 gcttgaatcc aggaggtgga ggttgcagtg agccaaattt gtgacactgc actccagtct 23400 gggtgacaag agtgaaactc tgtctaaaac aaacaaacaa acaaacaaac aaacaaacaa 23460 acaaacaaac agtgaaaggg accagtagag aaatggaaca tcttttattg acgttttgtt 23520 atactcacaa aaatagctga gtttgccttt atgtttaacc attatgtaat ggacaaacaa 23580 tgagattacc atagtgaatg ctaaatgaaa ctaccaacat cgtgtgtttc cacacagatg 23640 ataaaacctt tgtttttatg ccaagaaagc atctctgtct tctagtgtcc aagccactag 23700 cagcaccagg gcagaaaatt aatccattca tgtgtctttt ctaattaaca tcactctgca 23760 gttcctccta gtaccacgtc ccgctgcatg ttccacggca aaaacatagg ataataatct 23820 taggaagaac agtacatctc tgcttatagt tttttggaaa gccagttaga agagcattat 23880 agagattgct aattagttag ggctgcctct tcttactacc tgtctgctgg gtaacttccc 23940 catagagtgt tcttgattat aaaacacaca tatgtgtaaa atatgaacga tcaccactgt 24000 tgtcaatgaa ctctactcaa ataatcaatc tctaatggtt gtgtttttaa aaatccctct 24060 gtcattcttt aaaaaaatga atatacctga gatataaaac ctttatttta aaacaaaagc 24120 taaaggtgac agggaggatt ttggcatcag ctttcttttc tctgtaaagg atgaagattt 24180 Página 200

P201430887 ES 2 553 786 A1 09-06-2014 ttaaaatttg taaaatatat atacaatttt gtgttttaca taggaaacaa gaatgggaac 24240   ttgtttttct taatgaaagg aggcatcaca tgagctaaga aaggcattgt gcccacacca 24300 gtgagctcgg gaaaagagct tccagggatg tcaaaggaaa ctgtgaattt tccttggaca 24360 ctgtaaaact tttctgtaga aaacaccaca gaggatgtga tacataaagc atagaagcag 24420 aaaaccagac aattttaaag cttttaaatt gtgcatagat ctgattcctt gtaacattaa 24480 cattggtcat tggtccgcct tgctgtacac aagcacacat ggcccctgtg tgcccttgag 24540 gcttcagctc tcttgaataa caaagcatgc ccttgtatgt cccattattg tgtgtgtaag 24600 aggataatgt tgttattcag tgatgacaaa ttatccaacg tgtttctatg actggccact 24660 gtagatgttc agtcttttac aagagaatgt tcaaggattt tccctcaggg tccatttatc 24720 ttatttgcat gactataaat ttcaacccaa aagtaagtta caaatggaga agaaatagtg 24780 ttatcctgcg acttagggat catttttaaa agcttgactg tattgatcat atttaatcct 24840 tcttttaaac gtcttgatat gctgaggaag tggcaaatcc ttccgtgtcc tttgaggtca 24900 ttggtttagg cctgggaaat gttgaggaat tttgtggaat ttgtggagcc tctgtattat 24960 gcaatgatgt aggccatttc tatggccttc tgtgtaattc acaccccctg gcaccacact 25020 ctcttgaaga tccttcagga atcttatatt ttggctgaac agtggcaaat gctttgggcc 25080 ctaatcaagg gcctagtctt atataaaact tttgtgtggc aattactaaa aacacaagat 25140 cttaattact gtagcacaac aattatccta ctcattgtat cttataagaa ggattgtgat 25200 agcaatgttg ccaggttaat atatttccct atgcaaagaa ttaatctgca aatatattgt 25260 taggaacttt cttgtatatt aggaagggaa gagggcagtt ccgaacctgg caatctctgt 25320 ttcagttcac acaatgagaa gagcttgggt aagaatgtaa tttcactaga gcagaactct 25380 tcaattttgt gagacaagct ttggatcctt ttctacagtg agaacaaaaa caattttgtt 25440 ggcacaagga aacattaatt ttaaatataa aatgttcact gtcattgaaa agatcagaga 25500 tcagagtgaa tggtcttacc tataatatta ccatcattta aaaatgatac cctgagtgta 25560 gttttctgga atcccagaat ataaatagat aagctcaagc tcacatataa tctcttcttg 25620 tccctaacac atactcaagt tatcaaaaac atcgactaga ataattgtgc tcctccttga 25680 gtttaaatca gccaaattta aacattcgaa ctgatgctgt gaaatctctg gccctgactt 25740 ttagatttct cgatccctat tcctccctca gggctgctat ataaccccgt tctcagcatc 25800 aggttgggaa ttctctgttt gccattatgg gggagagaag aggtcttggt cagctgtttt 25860 tctgcccttt gtataacccc aggctaattc taatcagggt ttattcgatg ctcatggtcc 25920 ttctaggtaa ctagtttagg atgtcataaa aacaaggttg gataattatg tcatgaccgg 25980 tttcatatca ctctgcttaa cattgttctg cattaagtga ctgaatatag aggcaatgac 26040 aaaataaatg aacaaaacat cctgcccaat cccagacctg catttgagtt ttatgcaact 26100 aaacatcatt tgagaaaaaa gaacaacaaa aatttcatca aagtattttt tacatgaaaa 26160 ctttaaatgt agtttgagtt ctgattcacg aagttgcatg tacaaggtca ttttggtttt 26220 taaagaaaag agaagaaaca atagtttctg aaggcatcca gcaacatact gggttgagga 26280 Página 201

P201430887 ES 2 553 786 A1 09-06-2014 atcaccaaat cgtgactctg ttttgtagct gtggatttgt ataaaaaatt attctaatca 26340   tttgaggagg caggagaaat gaccaaaaat tagaaatcat ctctaaagtt ttggtaacct 26400 actcattgat tttccctggt aggtttggta gtggacaatt catgctacta cttttccctc 26460 caaatttagt ggaaatttct agaatatgta cccaagattg tcccctcaga aaagtgaata 26520 tgatgtttgg aaatttaact atgaggatgg cacaaatgaa aaattgctat aaatgtccct 26580 tttttacacc atgatttcta agaggttgcc tcttatccat tcagaatgca gaactgaaag 26640 agaatttcac attccttcat caacatgtgt tttgtttgcc catatttcgt gtttcttatt 26700 ggtttccaaa gaaacatgtc agaacactga ataatgcatg tggtcacttg ttctaatgct 26760 ttcacatttt ttgcatttct ttcttttaaa gcacaagact ctgctgacat tattttcctt 26820 attgatggat caaacaacac cggaagtgtc aatttcgcag tcattctcga cttccttgta 26880 aatctccttg agaaactccc aattggaact cagcagatcc gagtgggggt ggtccagttt 26940 agcgatgagc ccagaaccat gttctccttg gacacctact ccaccaaggc ccaggttctg 27000 ggtgcagtga aagccctcgg gtttgctggt ggggagttgg ccaatatcgg cctcgccctt 27060 gatttcgtgg tggagaacca cttcacccgg gcagggggca gccgcgtgga ggaaggggtt 27120 ccccaggtgc tggtcctcat aagtgccggg ccttctagtg acgagattcg ctacggggtg 27180 gtagcactga agcaggctag cgtgttctca ttcggccttg gagcccaggc cgcctccagg 27240 gcagagcttc agcacatagc taccgatgac aacttggtgt ttactgtccc ggaattccgt 27300 agctttgggg acctccagga gaaattactg ccgtacattg ttggcgtggc ccaaaggcac 27360 attgtcttga aaccgccaac cattgtcaca caaggtatgt atcctcttct caccatctgt 27420 gtgggagtgg ggtgttgtgt gtgttggttt acatagacgt aaggtgggta ccagcatgat 27480 tcgccacggg agaagctgta agtacccaca gtccagtcct tccctgatga gctgggtcct 27540 ggatgtcatg tttgtgatgt catgtgtgcg gaaaaactaa agaccaatga gtgagtgaaa 27600 gctcttacga gagtatgagt tgctgagaaa gcgtgctttt aaggctaatt caacaaacct 27660 gttgctttga gattattaaa catcaccgta ttaactactt ataatccagt cttcctaaaa 27720 atgggcttga ggggctcatt acagttctga gaaagttact ccaggactat ggcattgagc 27780 tctaaaagtc agtgttagaa gtgtgctcat agacagagta tctttccaaa agcaaagatg 27840 gagtgagggt gtctcctcaa agtcattttg tgctagggtg ctgagagtta tacttctgaa 27900 ggtaagaaat aacagtgtaa tcacttgatg aaatatttat gaagtttttt ttttcttgtg 27960 cttgtgaagt gtaggagtaa ttctcctgag tggcaatatt aggatacaag ctcaaatgga 28020 gggcctttgg caaaacagcc aattggagtg gtttaaaaaa caaaaaaacc aaccaagtca 28080 cataacaaat atgcacttaa caaacatagg aggtatggtg ggggcatcag gatgcatagc 28140 ctcctctacc ttttgaactg ttttctgaga catcagtcac ttttcagacc tatcaatttc 28200 attacctagg tcaggccaat aggatgccat ttggtaaatc agggacacag tggcccccaa 28260 cagtttccag aaacacccaa ctcacttcca gtgttgctta cacactggga tgctctaatg 28320 agattagtcc ttgactataa gaccttattc ttcattttcc ttccagagta tgggctcaat 28380 Página 202

P201430887 ES 2 553 786 A1 09-06-2014 gaaaattggt gaatggatac cgaggctcct ataagactct gattatcatc tgcaaccaat 28440   catctaaatt ttcttgggtg aaataacaca ttgttacaac tcttatttgc taactttata 28500 aataaagtct gggtctacaa gataaatatt gtaataagat actgctttac ccattgtatc 28560 aattacaatt gatcaaggga ggttttcctt tgataaagga gtgaaaataa tttaaaaata 28620 accattttgg agaatatgcc attgtatgaa attaagagta gaagatttta aagtcttaat 28680 taaaaacatc actatctatt tatttaagga gctgacctct acttaatagt gccttgctaa 28740 tcattagttc tagttgctgc attcatgtaa aggcaacaca ccacatttcc ttacaagggt 28800 tacaaaattc acactgagtt agattgaact tgcctcaaat gattttaaac cacagctttt 28860 gttgtaataa aaattacagg tagaaagctc aggctatggc atctctactt aatctgtgca 28920 ttggaactgt gaccaggtga tgtagcaaga aaagtatatg tgagtgttgc cttctggaga 28980 aggctgtgtc tggcatttat ttaagtttga aaggtcaatt ctgtgtggct tagcttttgc 29040 tgcatacagt tttccagctt ttcctctcac ttgatgggac cataaaattg gcccaaatcc 29100 tccagatgag ctaatagaga gactagaatt ttgaaaataa tgttctgaat gcaaatggac 29160 attgagaagc aatggaaaca gtgtacagga ctacatgccc ggtgcctgga gctgctcatg 29220 ctcattccat catggtgccg ttttgtgact ctggcaatta agaaaacaat caagtgaaaa 29280 tttatgacct gctgaggttt ctctgagctt gcatactatt ggtgtgcatc ccaaagtata 29340 gaagcccaga gatttcccta tgttttgcag acaccgacga tgcaacatgg ctgtagatgg 29400 gaaagctggt ctctggtctt gggtcttctg tggacctgcc atgtgatcct gggcaggtca 29460 tgcaacctct ctgggtttcg atttcttgaa tttatgacaa aggagttgca ccagatgaag 29520 atatgtctgt accaggagaa gtttcaactt tttaatgaaa atgggcagca catgaccctt 29580 gtttcagatt ttccctagcc aagtagagtt tcaacccctt gattacaaac atcatgttta 29640 atatcaatga ttaacttgta aatattcaac aaatatcctt gactatctgg catgtgccag 29700 acactatgcc aagcactaga gatatggtgc tgtttaatga gacagatgtg gctgctcgtc 29760 tgttacagga taatggggaa agagacaata ataatataaa ctagtgacca ggcaaaatat 29820 tctgagcatg ataagttgca ttggggcatt caacagggct gtgataggaa gactggggaa 29880 gggaatttta gatcaggtgg atggaaggcc ctgagaaggt gtggaaccga aggcagatga 29940 gcatgcggag agcaggggga agagtggtcc aggcagaagg aagagcagga ggggtggccc 30000 tgcaacaaga aggcacttag tcccttccca gaactgtcag aaggcagtgt agctggagca 30060 cactggacag ggagcctgag gttcagactc cctggatgca tggaagctgg agaagcagct 30120 gctgtagggg gatgagaagc cacagggagt ggagcctgtg ggttgggagc caatggcaga 30180 ggaaggtagg ctgtgggtta gtggtggggg caggggctct cctctgaggg cttctatttt 30240 ctcagagaca gatgaggagg ccttggaggc agtggcagag ggctgagcag agagcacagc 30300 catgagacag tcattctgga ggacaggaca gccaacttcc caaggaggca tgggaggatg 30360 gtgggcaggc acaggtctcc tgatgggggt ctggagttcc gagcgtggca tgcaggtacc 30420 ttgttgtgtg gtcttctcca ggaatgtcca ctgcttgggt gatgcatgag gaagactgtg 30480 Página 203

P201430887 ES 2 553 786 A1 09-06-2014 ggcctgatgg aggctttcag gagagtctga tggaggtgca gggatgaggc atggaggaaa 30540   acagagagag gcgtgggagg agggctgaag agggttgtgc catgttggtg aggagtagca 30600 ggaccttcaa gttcatctcc caacaaggca gtgaagtcag gccctgcaga gccacattaa 30660 agagataaga cagctgtgtt tgggttgata tttatgtcaa gtggaaggaa atgcgtatgc 30720 atccctgacg tggctcacag aagagtcagc tgtgagaatc ccaaggtttt tatcactggg 30780 tcagaggaga ttcatggtgc agcccccaga gaaatgaaat gattctgcaa agcctaggtg 30840 aattgcgtca gagtcatgaa gcaaacatag gaattcagtt attcttccag ttactcaata 30900 tttttcagtg tttactatat ttggctaagc atggttctag gcatatcatc tgtcatgagc 30960 tcccatgact tgaataaaaa tcaaacgtaa atgacctctt acctaatcaa aggggactct 31020 gggacagagc ctctgggaac cagaggtgca tttcagggtt cccagagctg aatccttgtt 31080 gggtgcaagg agactaggcc acttgtttca ttagatctag aaggtattcc ttcccgctgg 31140 ctcatcggga gaacttttag tgatgcagtg gtagggggag ggaaaacgtg ggagggtagg 31200 ggatgatatt tatcttctcc caccccaaga gttgtgccat tgctggtact tataaagaag 31260 aatataacaa tctgggccac ttggtatagg agcaagtagc ttctcaggtc attgttatat 31320 gagtatttgt ctatttttct gtcatgtgtg atatacatag taaatacatg agtggtagat 31380 tcatggtata gcatatatgg aatttatatg tgtctatata cgtgtatgtg tgtatctata 31440 tacatatata ttctctctaa tggtacaaag gtataagtct tctagagatc tacacattag 31500 ttttatctgc aaagatattt taaatcaaaa tgaaggggta gcccagagag acagcatgtt 31560 ctaaattaaa tgaaggaagg aaagcccaga atggatgttc ataacaatga ccatgaaata 31620 ttgagaaaag gttcaatgat gttctgcaca cattgttaca ccagtaggca actgtgttat 31680 tgtattaagg acgttggtgc ataacatgtt acccttctct tagaacatag accttgtctt 31740 gatgctacag gtgagcaccc agatgaggca ctgctgtctt catttggcat gtatcagcga 31800 ttctcacccc aggcatcacg ctcccagctt ctggtccaaa caactagaaa tgaactgcat 31860 ttcaaaaatg tgttctaggc tggatgtggt ggctcaccct tgtaatccca gcactgtggg 31920 aggctgaggc aggtggatca ctcaaggtca ggagtttgag accagcctga ccagcatggt 31980 gaaaccccat ctctaccaaa caaaacaaaa caaaacaaaa attagccggg cgtggtcgtg 32040 catacctgta atcccaacta ctcaggaggc tgaggtggga gaatcgcttg aacccaggaa 32100 gcggaggttg cagtgagctg agatcatgcc actgcactcc agcctgggtg atagagtgag 32160 attctgtcct aaaataaaaa taaaaataaa aatatgttct agaaggtagc tctgattctt 32220 agaaagttct tccttacctt catcccaaac tttgtttcct ttgtctgctt ttacaaaatc 32280 aacttgccat gcaatctatc tgatggaata cagtaacaga ggactctttt gcaaaacagt 32340 ccatctcagg tttaatcatt tatgttcctc tacttcttgg aatctctgtc aggtttttgg 32400 gttaggtgtt gtggtcttaa cagagttcat ggttcttgca atatgggcag ggtgcctgca 32460 catggataca gcagttcaca gtcactgtga gacagttatc ttattgagat gtttttgctt 32520 tatggtttgc ctttaagtta tcactgtcat attacttagg atctttaaaa acaggttttt 32580 Página 204

P201430887 ES 2 553 786 A1 09-06-2014 tgtttttttt ttggagatga aatctcactc tatcacccag gctggagtgc agtggtgcaa 32640   tcccggctta ctggaacctc ctccttccag gttcaagtga ttctcatgcc tcatcctcct 32700 gagtagctgg gattacaggt gtctgccccc acgctcggct aatttttgta tttttagtag 32760 tgatggggtt tccccttgtt ggccaggctg gtcttgagct cctgaactca gatgatccac 32820 ctgcctcagc ctcccaaagt gctgggatta caggcgtgag ccactgtgcc tggccaaaac 32880 gcaggtctct taagtgaaaa atgtttgcgg cacttgctgg ctttgatgct gatttccttt 32940 ttatacgttt tatgttaagt aattctttcg tctgtcaaat gaagacaggg aatatagaac 33000 tgaagagaac agggatgtgc aggctctttc agcttttgca cttgacaatg agcattttga 33060 aatgaagact gtgaggcaaa gggttctctg agcagacatc agtggtttct ttaattattc 33120 aagcaatgac ttcactctgg ccaagttgtg tatttacggc agaagagaac ttattgaatt 33180 ttcagtgaca gcatacaaaa caggtggcta ctaaaactaa atttgttttt gtgcaactat 33240 tttgtaaaaa gtactgactg ggcagggtgg aaggtgagcc agctttcctc cagcaggtgg 33300 ggaggcaacc ataacttatg tgttcattag gacaaattcc ctttggggtg gccctgtggt 33360 cacgttggcc acagtaaatg agggtgtcct ttaaatggag ttagctttgt tgaaagtcat 33420 tgttgattgt gcttggtaag gccattctaa ttgccttata atgttgccac ctacagtcat 33480 tgaagtcaac aagagagaca tagtcttcct ggtggatggc tcatctgcac tgggactggc 33540 caacttcaat gccatccgag acttcattgc taaagtcatc cagaggctgg aaatcggaca 33600 ggatcttatc caggtggcag tggcccagta tgcagacact gtgaggcctg aattttattt 33660 caatacccat ccaacaaaaa gggaagtcat aaccgctgtg cggaaaatga agcccctgga 33720 cggctcggcc ctgtacacgg gctctgctct agactttgtt cgtaacaacc tattcacgag 33780 ttcagccggc taccgggctg ccgaggggat tcctaagctt ttggtgctga tcacaggtgg 33840 taagtcccta gatgaaatca gccagcctgc ccaggagctg aagagaagca gcataatggc 33900 ctttgccatt gggaacaagg gtgccgatca ggctgagctg gaagagatcg ctttcgactc 33960 ctccctggtg ttcatcccag ctgagttccg agccgcccca ttgcaaggca tgctgcctgg 34020 cttgctggca cctctcagga ccctctctgg aacccctgaa ggtatggtgg tgatggcttc 34080 agacacacaa tggggtggtc tccaggcagg gcctttaaga acaaaacaaa atgaagtgtg 34140 tttgtgttta gctaagagac aacaaatgat gaaaacagca gcaacgaaca tgatttattc 34200 caggtttcct tttgcactgg gttcaggatt gtatggttta caatgtcatg caatgaaatt 34260 tcatataaga accatatgat ttaaaccaca ggaccatggg ccaccacctg tctttgaagc 34320 ttctggccga ggaggtcaca tctcagttct tatcgcttgt cagatccctg tgttcttctg 34380 tttctactgg tgatttctgt ccagtctcct cctcatcacc aggatgtagc tttcctttcc 34440 tgagttgtcc atctacttct aaacagcccc agtctgagct gtttagggca cagtgtcctc 34500 agcttttaat ccctctcttc tctctcgtta agggattacc ctcaatggga aagcatattg 34560 aatggctaag tgtggagttc aaacctagtg gttcttcaaa tccctcattt aatatgattg 34620 ccagtggaga gttattttta aagacattat acagatctat gagctaatga gttgaagaaa 34680 Página 205

P201430887 ES 2 553 786 A1 09-06-2014 tacaattcac tgcccttaat gaagagaaga tgagcatcac agaatgatgc tttcccacct 34740   tgcagactcg atcactagag gattgcctga tgcaggcatg acccatgctg cctggatgca 34800 tgctttctct tcacactccc tggtcttcta tatccatctc tttctctctc ttttaaaatt 34860 tttcttaaaa cttttaatcc acactttcat agccaaagtt caacttagga tacaattagt 34920 tgtgaggtct aaattacagt agggcatcag ggaagaaata aaaaataaaa ttttaaaggc 34980 acatggtaaa tgtgttgggt caaatacact attttgagaa ttatactttt tattcttgat 35040 gtgtataagt ttggccaagc ctagcaacta gtctccttct attttgctgt gtatttacgg 35100 tcccatcatc tcactttggg ggaattcccc tgttggatga ttgcctagca agactgtgac 35160 ttcctaatag gagaagagtc ccagtggaga atgacaaacg gggaagtctg aagaagactt 35220 caatatgaga ccagcctact tttgctattt tttttagcct taaggaactc gttttctcag 35280 gttagtgagg gctaactgct tctgagctat ggatggaaga ccctctgttt gtgggtagag 35340 gtgagcccca gaggatccag ccaggcaaac ttaaacctgg ctgggatgag tgatatggac 35400 tgatgcagca ccttcatagt attcattttt agggaaggag tgtttggttt caaggattct 35460 gatcactttt gttgtctgta aacattctaa ctttgatgtt gtagctctct ttgagccaac 35520 ttggttttgt aaactcggct accaatatgt ctcacaaaca ccagccacca ccagaggaaa 35580 atatgcagcc atctgccata ttttacaaga tggacatgct ttgccatgct gactttctct 35640 gtgttctaaa tgttggcatg tgtgcacgtg ttgtaggcac acatgataaa actctccgtg 35700 gttgtgtatg tctcactttt ttttctgtgc ttcactgcag ttcactcaaa caaaagggat 35760 atcatctttc ttttggatgg atcagccaac gttggaaaaa ccaatttccc ttatgtgcgc 35820 gactttgtaa tgaacctagt taacagcctt gatattggaa atgacaatat tcgtgttggt 35880 ttagtgcaat ttagtgacac tcctgtaacg gagttctctt taaacacata ccagaccaag 35940 tcagatatcc ttggtcatct gaggcagctg cagctccagg gaggttcggg cctgaacaca 36000 ggctcagccc taagctatgt ctatgccaac cacttcacgg aagctggcgg cagcaggatc 36060 cgtgaacacg tgccgcagct cctgcttctg ctcacagctg ggcagtctga ggactcctat 36120 ttgcaagctg ccaacgcctt gacacgcgcg ggcatcctga ctttttgtgt gggagctagc 36180 caggcgaata aggcagagct tgagcagatt gcttttaacc caagcctggt gtatctcatg 36240 gatgatttca gctccctgcc agctttgcct cagcagctga ttcagcccct aaccacatat 36300 gttagtggag gtgtggagga agtaccactc gctcagccag gtaaacctcc cctgttgccg 36360 ggaactccct ctccttcctc agacaccacc ctggagggta gtttgccagt ctgaactcaa 36420 gagcactgtg gactgtacaa agacaattgg ctcccttcca ttgaaatagt ttgaatgggg 36480 acttgagaca ctgtaccagc aaggctggac tctgtctaaa gggtgttcac gaaggaaagt 36540 ctagaacatc cagcttatgt tctgtccatt ttgcctcacc ctttattcag aaggattttt 36600 tttcctctaa tgactgtgag gattctggag ttcgaatcca gatttgggga tcatggggtg 36660 gagggagaca gagagagatt tttcttacat gaatatgcct tgggattatt taaacgttga 36720 aattgtattt ttacatgatt tttaaatgtt caacatctgc tgtatctaga aaattatttg 36780 Página 206

P201430887 ES 2 553 786 A1 09-06-2014 ttataaaaca aacaaagggt gcatcttcat gcaatggtaa aatggtttct aggggaaggc 36840   taacttatta ttattattgc aaattattat ggtggtaaga tatggttgta tcagatctac 36900 cagtctgcta acatcacaca gatgaatggc aagactaaac caattgaaac ctaatcaaaa 36960 tagttctaag aactgtttta actgagaatg ttatttacat tacacattgc ggtgccatag 37020 ggcctgtcat ctgtgtttcc tattgtctca ttacaacaga ttgggaagca ttgacaagga 37080 gcctgaccca cacagcagta atgggcacta ttgtgggtct tggcccgtaa cctcaaattt 37140 aatgatttga tcattcaatt acagcagatt catggcaacc cagttatctt tgagtggttg 37200 acccatatca gccccccctt tttttttcta gagattgaga tcaatttttt taagcaaagg 37260 tatattaagg gccatgtttt caatactttt atttgtaaca gtttgaaact gctgtctgtt 37320 ttcctggagc gattgccacc tgatgtaaga acacaaccca gtggggcttt tccctggctt 37380 gctttattga agaagcatga tgctagatgg gataggctgt tctagttact agctttgcaa 37440 atatgcactg atttgaaata ggacattttc aagacaagtg gtatgaattt gggttttctc 37500 ttctcttgct ggcacagtgg tcatcagatg agtttcacca actcctgttg tcaaatggtg 37560 ctgggctgaa gtcgctttgg ttcctgttat gctctcgtcc ctcattgtat cctaatctac 37620 cttcattgca gagagcaagc gagacattct gttcctcttt gacggctcag ccaatcttgt 37680 gggccagttc cctgttgtcc gtgactttct ctacaagatt atcgatgagc tcaatgtgaa 37740 gccagagggg acccgaattg cggtggctca gtacagcgat gatgtcaagg tggagtcccg 37800 ttttgatgag caccagagta agcctgagat cctgaatctt gtgaagagaa tgaagatcaa 37860 gacgggcaaa gccctcaacc tgggctacgc gctggactat gcacagaggt acatttttgt 37920 gaagtctgct ggcagccgga tcgaggatgg agtgcttcag ttcctggtgc tgctggtcgc 37980 aggaaggtca tctgaccgtg tggatgggcc agcaagtaac ctgaagcaga gtggggttgt 38040 gcctttcatc ttccaagcca agaacgcaga ccctgctgag ttagagcaga tcgtgctgtc 38100 tccagcgttt atcctggctg cagagtcgct tcccaagatt ggagatcttc atccacagat 38160 agtgaatctc ttaaaatcag tgcacaacgg agcaccagca ccaggtatgg tagagaaatg 38220 ctagttgctc tgccactcag ttctctaatg catgagttga gggtaggctg ctggccactg 38280 gtccttagat agaagccctc cttgagttta caggaaaggt ggaaaattaa tcacctgctg 38340 gtttcagcag gaacaataga atatgagatg tccctcctta ctttgattct ctagctgctc 38400 tctcaggaga atgagggtga gtatttttaa gggcattaga ttatttcata gtaagacatg 38460 ttataaagat ttagatatca gtggttaaaa tcctttttta aaaacagttt ttatggtatg 38520 cataataaaa gccatatcat atggttacat tgtacctaaa acagccttca tcttcatatt 38580 cacccaatgc ctttatattg ttataattcc ttcattacat tcattaaaaa ttaaaggagt 38640 agaagaggta gataactttc caccataaac tctgcattaa aatcccccaa ctgctaattg 38700 acactgccat gacttttcat ttaacccctt taatttagtg ataaaaatgc agtgaagaga 38760 gtaatttccc ctgtatgcct tttgatgaaa aatgaagact ccagagcctc tcctttgatt 38820 actgggccca ttggccgttg gcttgggatg gtaactccga catctgggtt ccgtttcctc 38880 Página 207

P201430887 ES 2 553 786 A1 09-06-2014 ccattaaccc acttgtgact tgcagcaact caattgaaac ctcccatcga taaaatgcta 38940   gtggttgtgc aggtgctgcc atctcatgtc tctcctccca tcccaagttt tttcttgaat 39000 acatctttga aagctaacaa tactcttcaa gcattgaaaa gttccaaaat aaaaggggtc 39060 cctatattgg tgtattagtt tcccattgct gttataacaa agtaacacaa atttagtggc 39120 caaaaacaaa acaggccggg tgcggtggct cacacctgta atcccagcac tctgggaggc 39180 caaggcgggc ccattgcctg aggtcaggag ttggagacca gcctgaccaa catggtgaaa 39240 ccctgtctct accaaaaata caaaaattag ctgggtgtgg tggcgggtgc ctgtaatccc 39300 agctactctg gaggctgagg cagaagaatc acttgaaccc gggaggcgga ggttgcagtg 39360 agctgagatt gcgccactgc actctagcct gggcgacaag agcgaaattc tgtccacccc 39420 ccgacccctc cactgcaaaa caaaaacaaa aacaaaaaca aaaatcctta ttatctgaca 39480 gttttgaagg ctggaaattg gaaaccagtg ttgctaagct aaaatcaagg tgtcaacagg 39540 ctgtgttctt tctgcaggtt ctaagggatt cttcatctgc tcaccttttc cagcctccag 39600 gggctgcctg cattccttgc ctcctggccc catcctccat cctcattgcc agcagcttgg 39660 cactttctct cctctctgac ttctgtttcc atccttacat cttctctcta actctgaccc 39720 tcttaccccc tcttataagg acacttgtga ttgattacat tgggcccacc tggctaattc 39780 cagggtaatc cccccatccc caaatcctta cctgaatcac atctgcaaag tccttttctc 39840 aagttcgggg atttggactt ggacatccct gtgatgctct tatgcagccc acctcgttga 39900 tatgaaattg ctgctctgat gtcctgtgtg agttaccagg ctgtcctcct cccagtttca 39960 ggtgaaaagg acgtggtgtt tctgcttgat ggctctgagg gcgtcaggag cggcttccct 40020 ctgttgaaag agtttgtcca gagagtggtg gaaagcctgg atgtgggcca ggaccgggtc 40080 cgcgtggccg tggtgcagta cagcgaccgg accaggcccg agttctacct gaattcatac 40140 atgaacaagc aggacgtcgt caacgctgtc cgccagctga ccctgctggg agggccgacc 40200 cccaacaccg gggccgccct ggagtttgtc ctgaggaaca tcctggtcag ctctgcggga 40260 agcaggataa cagaaggtgt gccccagctg ctgatcgtcc tcacggccga caggtctggg 40320 gatgatgtgc ggaacccctc cgtggtcgtg aagaggggtg gggctgtgcc cattggcatt 40380 ggcatcggga acgctgacat cacagagatg cagaccatct ccttcatccc ggactttgcc 40440 gtggccattc ccacctttcg ccagctgggg accgtccaac aggtcatctc tgagagggtg 40500 acccagctca cccgcgagga gctgagcagg ctgcagccgg tgttgcagcc tctaccgagc 40560 ccaggtacgc agggaactct ttgcatcctc actcagtgtc attgtctggg gctacttgtc 40620 tggactgtgg gccacaaggt gttctcaatt ttgcttttcc tgccatgtga agtgaaaact 40680 aaaattacag gaaaatttag gaacccacat gccctttttg gcctcgatgg gcagaaatgg 40740 cagaggttca aggggggaga tgctaagatt catgttttgg ggcaaattaa attctccaaa 40800 agggacatat gtgcagcttg gaattcagga ctccttaact ttgcatgaaa gcttctgtct 40860 agatatccaa agggaggggc cgtctaactg ataacgcctg ttgcgtatca gtcctgcgac 40920 ccctggtagg tttggtcagc agccttctgt gaggcaggaa ggagtctgac cagggacact 40980 Página 208

P201430887 ES 2 553 786 A1 09-06-2014 ctgcaagctg ggacatagac tctgaaatat tggtatctcc agagccaagg tgtgaagata 41040   attttgactt tgcttggtgc tgagaagtgt cttaactggc aggaaggcca cctggctctt 41100 atgaccatag tttattctat tttctttttc ctgttccctc tttctaggcc tggtacaata 41160 aactaaaaaa tggtgggagc cctggtgctg agaaggaagg aggaaagata tatctacctc 41220 tcaataaatg tcctccaagg gccactctcc cgggtcactc gggtgggggg ggttcacagt 41280 ggcgaaggag gcagatgcgg ccttgctccc tcatatgcac tcacttgcct gctcttccaa 41340 gaggagagaa aagaaggaaa gttggggagg agcggaggaa ggagtaaaag caagtgaaag 41400 gaaatcactg caggatacag tgggtgatga gggaggtgag gatgattatt tgggtgcaac 41460 tgagaggggc ttggtttctc ctcgctggtg cctggggaag agagcagtgt ggcccaccag 41520 gtttctgtgg gatgttcctg agcatttatg atcaggtaaa tttgggcaac agtgggataa 41580 acaaagtgaa agaggctttc tttcttccta actaaggcgc tttgtgtgtc tccaacacaa 41640 gaaaggaaat gcaacatttc caaaatgtat ctgcctgcag gaggcctctg tgatgctgtg 41700 tcttggcccc agattgccga ggatggactt tgggaatatt gtcacagtgc gggtgcagct 41760 tctgttgtca ggaacgtaca tttccacaac gctgtggctc tttgcccact cactctcctg 41820 cgctccagaa cagcctccct ctttccccct tctccccatt cggaggcttc tctcacacct 41880 ctcctgaccc acctgactct cagctggtaa tcttgagtcc tatttctcca agaaaatgca 41940 agtaaaccca aagagagctg tccccggcca cgtcatcccg tggttccttg ggtggcctgt 42000 ctccgcttcc tcagctccct ttcctctcac ctgctcagtg gcaccatctg cagttccctt 42060 tcttgctctt gtgtcaccct ttctccactg tgctggatgg ttccatccat gataaaatgc 42120 attgcttctt ctctcttaaa caccctctct gatgcgccac ttcccctgcc agcagcacct 42180 gtctcctaaa gacttatcta tactctaaag ttcctttcct cccatcctct ctgagcccac 42240 cctactttgt cattcaccct tgctcctccc ccaagtgctc cagttgaggt cactccatct 42300 gacaaggtcc ctgtctctgg cgaagcccag tggctgaccc tcgggtccct gagcagcacc 42360 tgatgcagtg caggtcacgt ccttcccaag taccatcctc gctggtgctg atgaggctct 42420 tctgattctg cctccgtcgg gtttttcatc ctttgctccc cttctctttg atgtgtaaac 42480 actgaaatgc ccaggactcc cacttcttgg acttttaaca gtggtgattg gtgttaggat 42540 cccctgcctg tgaatccatg acaaactggg cggtggctca tgaacgctaa gaatttggtg 42600 acgatgaagg tgaagccatg ctcacatttg tttcgcaggt gttggtggca agagggacgt 42660 ggtctttctc atcgatgggt cccaaagtgc cgggcctgag ttccagtacg ttcgcaccct 42720 catagagagg ctggttgact acctggacgt gggctttgac accacccggg tggctgtcat 42780 ccagttcagc gatgacccca aggtggagtt cctgctgaac gcccattcca gcaaggatga 42840 agtgcagaac gcggtgcagc ggctgaggcc caagggaggg cggcagatca acgtgggcaa 42900 tgccctggag tacgtgtcca ggaacatctt caagaggccc ctggggagcc gcattgaaga 42960 gggcgtcccg cagttcctgg tcctcatctc gtctggaaag tctgacgatg aggtggacga 43020 cccggcggtg gagctcaagc agtttggcgt ggcccctttc acgatcgcca ggaacgcaga 43080 Página 209

P201430887 ES 2 553 786 A1 09-06-2014 ccaggaggag ctggtgaaga tctcgctgag ccccgaatat gtgttctcgg tgagcacctt 43140   ccgggagctg cccagcctgg agcagaaact gctgacgccc atcacgaccc tgacctcaga 43200 gcagatccag aagctcttag ccagcactcg ctatccacct ccaggtgaga tgggggcgtc 43260 ggaggttctc cttggagcat tttccatatg aaaaataaca ggctcaaagg ccatggtact 43320 cataataaat taaattaaaa taaaggttgt atgcccttac ctttatggtt tttattttga 43380 gacagggtct ggctctgtcg tccaggctgg agtgcagtgg catgatcata actcatttta 43440 acctctgcct tctgggatcc agccaacctc ccacttcagc ctcctcagta gctaggacta 43500 caggttcata ccaccacgcc cggctaattt tttgtatttt ttgtggagac ggggtttcac 43560 catgttggcc aggctggtct caagcccctg agctcaagtg atccacctgc tgcggcctcc 43620 caaagtgctg ggattacagg cctgagacac cgcgcccagc acctttatgt tcttcatgcc 43680 caccagccag accccaccag gacacacctg cgactgaaca agttgggtct attgctcatg 43740 gcatccaggg agaatgcata ccgtggcaaa gcatgagggc atctccatag gagggtggcc 43800 ggaaggactg gggggacttg agctagtggc aggtcatttt gtggaaggct taaagaaatg 43860 gaactgtggc ctggattgga tgttgtcaag acgtggaggt gattctgtag ctgtatctta 43920 agtcttacct agaagcagga tggccttggt atagattggt agagaagagc agtcactctt 43980 attaaccagg acagggagtg tttttgtcct ttttgtggtt tgcaccatgt ttttcttttt 44040 gtctgtgttc agatagggtt acaatgtggt ctcattttca tcttgcccca ttgtgatcac 44100 agagtagcct tgtctgttgt gggggtcctg tgagatcatg tgtgctcaac aggagaaccc 44160 caaggccatg tgtgctggac cagctcccca atgcgggggc tgattctctc tttcttaaac 44220 agctccatca caagagctgc tcagcttcca ctatgctgca tttacaccgt aaattgccca 44280 attgtgtatg aggcaaaggg caggttgaaa tgtgtggagt agcaacatac aagtttaata 44340 aaatagcatc tgaggagtac ctaaaattct aactaatagg aaaatgtggc tcatctttct 44400 caggatcttt tgattaattt tattgttaaa aatgcactag gctgggcgtg gtggctcacg 44460 cctgtaatcc cagcactttg ggaggccgag gtgggctgat catgaggcca ggagttcgag 44520 accagcctgg tcaatatggt gaaaccccat ctctactcaa aatacaaaaa ttagctgggt 44580 gtggtggcac acacctgtag tcccagctac tcgggaggct gaggcagatg aatcacttga 44640 acctgggagg cagaggttgc agtgagccga gattgcgcca ctgcactcca gcctgggcga 44700 cagagcaaga ctccatctaa aaaaaaaaaa aaaaattaaa ccagttattt aatagaatta 44760 aatattttta aaaatgcgct aatgtaaaga aaatgagtca gggtgggtgg gggaagctgg 44820 gcatggcggc tcatgcctat aattctagca ctttgggagg ctgaggcagg aggatcactt 44880 gggcccagga gttcaagacc agcctgggca acacagtgag accctcatcc aaaaaattaa 44940 aaaaaaaaat tttaatgaaa tttaaaaaat aaaggcacag gcatggtggt tcatgtctgt 45000 agttccagct acttggagga taaggaggga ggattgcttg agcctgggag gtcaaggctg 45060 cagtgagctg tgactgtgca actgcactcc agcctgggag atagaaagag accatgtctc 45120 agaaaaaaaa aaaagaaaga aaaggaaata gaggaataat agtgaaaaat aaaaacttca 45180 Página 210

P201430887 ES 2 553 786 A1 09-06-2014 tataaatgct agagatgtgt gagcaaaaag gaaatacgag ggcacaaatg cctggggagc 45240   attaatgtga ccccttggat atggcactgt gttatacgta ccctgccccc atgggctgag 45300 attgcgcagc atgctgggat ggtgttgggc tcctcagggg tctcacttgc taagtgatgg 45360 ccttggacaa ggcgagaacc tttggcctca gctgtttctc ttcttgtaca acaaagatat 45420 agatcccagt ggccttggtc tcttctggta gcaacagttc atgattctgt agattacggt 45480 agcccaagat tgatttctaa atgctcctta cattttagaa atcagtagta acccagacca 45540 caatgccaaa atttaaatag agtaaattca gaaagacacg ttttggataa cttcaaatat 45600 ttcaaggagc agaaattgtt ttggtgtaaa aggtccaatt tttaacggct aatttcaaaa 45660 agcccgagat acaaacaaca caggcatctt gggatataat cttaaggttg attaggatta 45720 tggtgcaagg tgcacaccaa acctgggtga gggctactta cacactgaat gtttcccttt 45780 ttcttctttg atctgcagca gttgagagtg atgctgcaga cattgtcttt ctgatcgaca 45840 gctctgaggg agttaggcca gatggctttg cacatattcg agattttgtt agcaggattg 45900 ttcgaagact caacatcggc cccagtaaag tgagagttgg ggtcgtgcag ttcagcaatg 45960 atgtcttccc agaattctat ctgaaaacct acagatccca ggccccggtg ctggacgcca 46020 tacggcgcct gaggctcaga ggggggtccc cactgaacac tggcaaggct ctcgaatttg 46080 tggcaagaaa cctctttgtt aagtctgcgg ggagtcgcat agaagacggg gtgccccaac 46140 acctggtcct ggtcctgggt ggaaaatccc aggacgatgt gtccaggttc gcccaggtga 46200 tccgttcctc gggcattgtg agtttagggg taggagaccg gaacatcgac agaacagagc 46260 tgcagaccat caccaatgac cccagactgg tcttcacagt gcgagagttc agagagcttc 46320 ccaacataga agaaagaatc atgaactcgt ttggaccctc cgcagccact cctgcacctc 46380 caggggtgga cacccctcct ccttcacggc caggtatgca ccgtgtgacc catgactaca 46440 gagtgtgaca tcaacatttt ttttttagtt aaaaaagtaa tcagtagtca tttttaataa 46500 ttttcttctc tctgggttgt ttcttcagat aatattagaa attaaatact ggaaaagtag 46560 ttccattgaa attgcagaag gaagcatatt attgatcttc catcactcct gagactaatc 46620 atagccccat tgaaaggttc tgcagtgttg cactgagata attacaaact cattggctct 46680 cagaatagga tggcatcttt gaaatcagcc agtccatgcc ccactgaatg tgactttgaa 46740 gttggcccat gcctactggc cagatgccca atatagtcca ggtcccctca ttccttggcc 46800 tggtgggacc atcagggagc accttcctgg aagacttgca gtcgtccacc tcagcttcta 46860 ccccgtgctc ctggttctcg tctttggggc tgcaaaagca aagtggatct ctccaccagc 46920 ccatattttt ctttgtccct cctccaagta atcgccatgt agacatctga agcaaaccat 46980 tagggttggt tcttcaaagg ggagcagtat gcctgtttcc ctagctcact gctccctacc 47040 aggctgcctg tggcacatct cacatccctc acactgtctc tcatcctttc tcctctctat 47100 tccagtctca gttgcttaat tataatcaag aaattaccct ccacaccact gatattcagc 47160 cagctcctac aaagctctca gaccatcatc caaaggttaa ggggcctctt cctattttcc 47220 aatctgtttc tcctagtcct tccttgcttt gcacctcaca cacatctctt cacttccagg 47280 Página 211

P201430887 ES 2 553 786 A1 09-06-2014 aactatttaa aattcttgac cacaaaggaa acttctagtg gcatttccta aaacacttga 47340   gatcacaaat gtcaaagcca ggtccctatt gaattcttgt cacaatgcca ttttgcacgg 47400 gataactgaa gttctctgtc actgagtttt cacagagtgt gacatcaaat aatttttctc 47460 ctttcctttt tgtttagagg atttatcatt catcttcttg tatttagcat gtttgggagc 47520 tgcaaattca ggaactacag gctaaagagg catggatttg agtgaaggtt tcactgtgaa 47580 taaattatta ggaatgtctt atttcagtta tttaatttta ccttttgtgt atttatgttc 47640 tgggtctgga aacctaatct ctccttattt tcactttaat cacttctaga gaagaagaaa 47700 gcagacattg tgttcctgtt ggatggttcc atcaacttca ggagggacag tttccaggaa 47760 gtgcttcgtt ttgtgtctga aatagtggac acagtttatg aagatggcga ctccatccaa 47820 gtggggcttg tccagtacaa ctctgacccc actgacgaat tcttcctgaa ggacttctct 47880 accaagaggc agattattga cgccatcaac aaagtggtct acaaaggggg aagacacgcc 47940 aacactaagg tgggccttga gcacctgcgg gtaaaccact ttgtgcctga ggcaggcagc 48000 cgcctggacc agcgggtccc tcagattgcc tttgtgatca cgggaggaaa gtcggtggaa 48060 gatgcacagg atgtgagcct ggccctcacc cagagggggg tcaaagtgtt tgctgttgga 48120 gtgaggaata tcgactcgga ggaggttgga aagatagcgt ccaacagcgc cacagcgttc 48180 cgcgtgggca acgtccagga gctgtccgaa ctgagcgagc aagttttgga aactttgcat 48240 gatgcgatgc atgaaaccct ttgccctggt gtaactgatg ctgccaaagg taactcccat 48300 tatgtgcata ttttccatcc tttcctgttg acatttgtgc ctctttagct gtctggtccc 48360 tggtgctgac ctctggagtc cttaggcatt tggttgcttc atacatttac ttatacccac 48420 tgggactggt cctgacaccc acctcaccac tacctagggc gttcttccaa gacaagagta 48480 gaagtctatc atattttgct tttataagat ttacttttct cccctattcc ttaatccctc 48540 aaacaattca gatttattga ttcctgtgtc taattataga tttattagat caagtatttg 48600 agatcagaat atttgatttt caagtgcttt taatttaaag cacaaacttg gggtgcatct 48660 aaacaccagt ggtgtatcat cacaccaaag ttaattaaca ccaccaacaa agctgacttt 48720 ttaaaatagc ttactatttg gcacctaaca gctaccctca tttctctctg tgagaggggt 48780 ggatagaatt gcttctcaaa gctcacacac acaggatctc attttgcact tgagtgcgat 48840 gccctggtcc tctgcctggg ttgtccctac tgctggtata agtagagttc gtctcctcag 48900 ccccagctga gaactcatca cctgcatttc tcctttccag cttgtaatct ggatgtgatt 48960 ctggggtttg atggttctag agaccagaat gtttttgtgg cccagaaggg cttcgagtcc 49020 aaggtggacg ccatcttgaa cagaatcagc cagatgcaca gggtcagctg cagcggtggc 49080 cgctcgccca ccgtgcgtgt gtcagtggtg gccaacacgc cctcgggccc ggtggaggcc 49140 tttgactttg acgagtacca gccagagatg ctcgagaagt tccggaacat gcgcagccag 49200 cacccctacg tcctcacgga ggacaccctg aaggtctacc tgaacaagtt cagacagtcc 49260 tcgccggaca gcgtgaaggt ctgtggggcc agttggttca ggtgctccct gggaaatttc 49320 caaattttta ctggaaagga ggaagccctt cccccaagtt aaatcctctt catgtttcac 49380 Página 212

P201430887 ES 2 553 786 A1 09-06-2014 tggattgtta gtgtctatat ggaaaatccc ttagttatta actgatctaa tgtcatgtac 49440   tgtcttcctc attttggtag tcttacgtaa gctctaaaag aatcctggaa atcagtagtt 49500 taacttgaat gagttgaatt tgtgattgat ttatgtttaa ttatagtcca gtcaggtacg 49560 ttctccactt tcatttctct gtgtgtatgt gtgcatgcat gcatgtgtgt atatacatgc 49620 atatatattg tgtagacaca cacaccatgt gagtttgcta gggatcatca tgaagtacta 49680 cagcctggcg ggcttttgga acagacattt attttctcac agtcttggag gcttgacatc 49740 ctcgaggtgt cggcagggct gtttctcctg agtcttctct gcttggcttg taggcagggg 49800 tcttctccct gtgtctccac atggctttct ctctgtgcat gtctgtgtcc aaatctcctc 49860 ttctaaaagg acatcagtca tactagatta aggttcactc taaagatctc attaacctta 49920 attacctctt taaagaccct atctccaaat acagtcccat tcttacggta ctggggttta 49980 ggacttaaca tacaaatttt gaggggacac aatttagccc ataacacatg cacacatgca 50040 cacacgcaca cacacccaca gacatgcacc cacacacatg cacgcacatg cacccataca 50100 catgcacaca catacgcacc cacacacatg tacacccaca cacccacaca tgcacacaca 50160 cgtgcacaca catgcacaca caatgcaccc atacacacac atatgtaccc acacacatgc 50220 acacacatgc acgcacacat gcatgcacac atatgcatat gattcgcaga aactacatct 50280 tagaaatatg agaatgagat aaaaattgtt tttattgtca ttgctgcttg tcttttttaa 50340 aataaattaa gcactcaaat atactcctcc attttaagtg caatatcaaa gtcttgtgaa 50400 catgggtaat cattcctcaa cttgggccct cagtttcctt aagtgtaaaa tgaagggctt 50460 gagacagcga gtctctcagt tttctatcag cagtctgcaa cactcctttt tagttttcct 50520 gggatttgac agctctctta tctgcaggtg gtcattcatt ttactgatgg agcagacgga 50580 gatctggctg atttacacag agcatctgag aacctccgcc aagaaggtag gtgccaaggc 50640 tttctaaata tgagaagtaa accctggtga ggcggggtgt actgctctgc tggagagaaa 50700 cctctctgct aatgcagcgc cccaagggag cagcgttgtc ttgggagact cttcctccca 50760 gcgttgtggc ccttcatcac ctgcttggag ctgtgggatg gagctaacaa aaattccttc 50820 tgtacttaga cagctttact gttgtgttgt ggctgttcag gtggtagaat gttcagaaag 50880 catgatgctt ttgcaaaaga tcatgacgta ttgattcatt taacttcatc acataaacta 50940 ggaattagtt actaataaaa atacattgct ctatttttgg tttgcagtta tcacagttca 51000 acatttaata acactacacc caaataatac aaagaaaata atgtaagcaa tgacgtacca 51060 aacataaggt gacagccatg cctattatca gatgtgatct ttgactattc acttgctttg 51120 gcgtttggta gcactgacta tcagaaagtg gatgccatta cagaagtgta atttatccta 51180 agaactttct atttattagc ttacttttcc caagcaatgg agatgaggct gctattatct 51240 gattttggag gtgttagtat ttcaatactt cccacagcat actcgtgtta cagagggcct 51300 gagtttgaga actcatgcat gaatacactt catggatgcc acttcctata tttttagtaa 51360 taggtttagt tattgacata ccggaaacaa ttattcagca gagtccaaag tttgagtatt 51420 tcaacaattc agagtagcca gtaaacttga ttaaatatat ttaagttaaa agctaaattt 51480 Página 213

P201430887 ES 2 553 786 A1 09-06-2014 tacactgaag ttttctttaa aaatgtagtc aggaaaaaag gacattgcat tttccacatg 51540   cctaggtgag ctgtattaaa tgtgtctttc tttgcaggag tccgtgcctt gatcctggtg 51600 ggccttgaac gagtggtcaa cttggagcgg ctaatgcatc tggagtttgg gcgagggttt 51660 atgtatgaca ggcccctgag gcttaacttg ctggacttgg attatgaact agcggagcag 51720 cttgtgagtt ttttttatgt ctttatacac agaccagtgt agataccaca ccttttggca 51780 tttcaagaga atgaagttaa ttatcagcag gtgaatggag gtgggggggg ggccttggta 51840 gatagttaaa tttatttaat tcacttggga actgccttgt tgccataaca catgtgaatc 51900 tggaaatgga gatagcaaat cgctggaaat ccagcgagct ggaaggggat cctgggcgcg 51960 ctgaggttgt ggccttagca ttttctctgc tcccttagca acggcctctt ttaacaccat 52020 tgcagggatg caaaccatcg agattgtcca tcctccaatt ggaaactgtg tcaagagcat 52080 ctgaaatctt gcatgataaa aacaacatgc aggaaaagaa aggctgtttc tgggtggaga 52140 agtgctttaa ttgccctccc tagtttccct ctgtgtcaat gaagctccct ctgaggcttc 52200 ctcattctcc ccagggccag cctctctcag ctggaggtgt gacctcctgg gtttagactg 52260 gggatggagc ttttggaaga tgtggggctg agctgcgaac tcagagattc tttgatggta 52320 gcaacagtgg actgtggcta tgagaatggg aggaatggac cttcctttct tccatacttc 52380 tttgcagggt tagaatcagg atttttttcc tagtggaagt aggttgagtt agctcacaaa 52440 tctgggatat gggagaaagg gaaagctctt ggaagctcgt tggaagaaag tgcatgtgcc 52500 caccattagt ttagcagatg gaaatgtatt tgggcatgcc ctttcccaca taaggtcagg 52560 ggccagatgg gatgagaatg tagagggtgt ctgtgtgacc tggagttgag aagcttttgg 52620 ctccgaggcc aggaccactt gtgcctgctc ccaccatggc tgctctggaa gcctctttct 52680 gggctggtac catatcccat gactctcacc ctggttccaa ggaagggtgg tcatggatat 52740 ctgttctgga accaccttca gtcttggcca tctgccattt gcttggcttt gcactttgga 52800 actggaacat atgtaagtta tagttaagat ctgatgatgg aaacttctag aaataaggtc 52860 cagcctgcag tgatattgtg gataagatct attttacttt ggttgttctt tactttccta 52920 ttggtgacct cccatctgca ccccgaccgc caggagctgg gccctcctga cttcgctggc 52980 aatttctatc atatcgtcag tcgtccagca aatgtcacct ggagggactt catctcacac 53040 cgtgaaaccc ccacacatcc gattttgacc cttaaagcgc atttatgatt ttctgctggg 53100 catttcttga gatctgaaca tttggtttct cttcctttcg gtaggacaac attgccgaga 53160 aagcttgctg tggggttccc tgcaagtgct ctgggcagag gggagaccgc gggcccatcg 53220 gcagcatcgg gccaaaggta cggtggcttt acccttgccc acgcctgaga tgaggtgtca 53280 gaagcccgac attactttgg tggggtaatt tctctaacag aagagtgtgg agatgaagga 53340 ggagacgaga gaccatttct tatgttagaa ggaggagctc tgaggggcag acctgcgtgc 53400 tgttctgctg gggcctgttc cagtgaagat ggttcaggcg ggaccctcct tttgcacagg 53460 ataaggggat ctgtgcttta acagcttggt ccttcatttc ataaaataat gttaaaggca 53520 gctggcgtcc ctgacagcag cctggctgcg aatggcagct ggaactcata gcatttgctc 53580 Página 214

P201430887 ES 2 553 786 A1 09-06-2014 tgagtcagta ggaactaaca ggctttcttg gcagagcagg agccttagag atcctgatag 53640   agagaatcgt gacatggtgt actgagggga aaagcagtaa cagggaaagc catgctgagt 53700 tttagtgctg ctctgccaaa tgaaggggga ccacagggat tcttactgta gagcaaagaa 53760 gaccacggga ttaaacagag gacccgatta ctttgtttca gggtattcct ggagaagacg 53820 gctaccgagg ctatcctggt gatgagggtg gacccgtaag taaaaattgt tttagtccct 53880 aaaatttcac cccctccttg atccttaccc attgggattg cattgtggat ttcatcattt 53940 gttcagttgc tgatggcttt ccctttggga gaaaaattaa tttatacttt tcttaacaac 54000 tttgcctgga tgtctaagta cgataattga agtatgacaa atgtgggcat gaagggtggg 54060 atttgttctt actctgtttc agaaggaggg attaattggt ttctgagcca gagggacacc 54120 gaatttgcac acccagtatc tactagatta agacatgcaa gtagagatgg gagtgagctg 54180 aggggcaggg acacagcagg agacctcacc agggctttag gggttacccc gttaagggta 54240 gtccctggag gggatgttgc tggatcagat catcagtatc cgagggtctt ggggatggac 54300 agaccccagt agcagggtcc atgggagcaa tgcccaagac agacacctgt ctggggagct 54360 ttgggaccct agatcaaggt ccagccctgg gataggggac agaggggctc acgaggaaca 54420 gtgtggtcac cagggcccag ccggcagggc tcggctagag aactgggaat caagcatcac 54480 ttggaggagc tgtcagcccg gtgggtcttc ccgggattca gcacccacag agacacagtg 54540 ctgggggcca cccacccttg ccccacaggg cagtgctgtc tgcgctgcta ccctcccaga 54600 tctcattccc ttcagggaaa ctgcaggttc caggccaggc ctcatgcagg ggcccaagag 54660 gctccctggc tcacgtagcc tcgatcggcg ttccccatgg tgaaatctgc tttctgctgc 54720 atgctgttca cagtaccctt tacgctgctg caagcccggc agagaaaggg tgatgaaggg 54780 ctccagcttg caaaatgcct ttgtctctca caacagggtg agcgtggtcc gcctggtgtg 54840 aacggcactc aaggtttcca gggctgcccg ggccagagag gagtaaaggt gaggcgtggg 54900 tgatggggtt gctagcgtgg ggaggggtca ggtgactcgc agtttctcca gatgctgcca 54960 gggagggagg cgctggtcca ggcttcttga cctcagcatt cagcagcccg tgacctctca 55020 ttggaaggca gttctgagca gggtgggttc aggagcaggg gctgcagctg gtggggagcc 55080 tgagaatgga gaaatagttt cctgtggaaa catgaagaag ccaggaaacc ctcacaagga 55140 gagaacatgg gccagggcgg agggtaggct ggtgcccacg gccccggccc tggaccgtgg 55200 gagcagtcag ggaagggagt ggagtgagag gacagcaggt gggttgaagg ctggtgaact 55260 tgcttctctg tttgctgaag tttgaaggca ggtgctgaag ggaagggctg caaagttaca 55320 aagtcagctc cttgccctgg gttttggggt ccacccccgc cggcccaggg agccaagacc 55380 acccaagcat tcagttctag ttttagtttt aaaacatcgc acgtggtggt gagagaggaa 55440 tccaaagggg taggactcta atattacatt ttcagacact gcaacattca aatggggtgg 55500 agtgggggaa cagcccttgg cctcttctgc ccgagggacc agccctgcag gaaaagctaa 55560 tgcttcccct atcgccttgc cttctagggc tctcggggat tcccaggaga gaaggtatgc 55620 aagcttggtt ttgttttaca aatggaaaac tctcccagta tttctcattt cttcctttgc 55680 Página 215

P201430887 ES 2 553 786 A1 09-06-2014 cagaatagct ttctatactt acctgtccgc cttattccct cttagggcga agtaggagaa 55740   attggactgg atggtctgga tggtgaagat gtaagtgatt ttactctaag tccaaactgc 55800 ttttggttct gaagattcca gaaactaaca actcagtctg tgatagaaat tgcagcaggt 55860 gtgaccttta atccttgtct ttggcaggga gacaaaggat tgcctggttc ttctggagag 55920 aaagggaatc ctggaagaag ggtaggtgta tttccacggt ggtgctatta tggaaagaat 55980 atcaacattt catttaggga atagttattt tctttcctca tatacatcaa gcccgcttcc 56040 tccaggcagc cttccctgac ctcccctgtg agtgcaccca ttacatcccc tctcagctct 56100 gacacattac agtacatttt cttgtttcga gatcacatcc catagggcag ggactgagtt 56160 tgttttgtta taaataaatc tccagtgcct ggcacaaagt gggtccccaa taaatattca 56220 tggatttact aaacgaatga aaaatatgtg gaagtgaatt tgccttcatg gtgaatgagt 56280 aaattgtaaa cattgttcta gttaagattt atgagttgaa gaatgtgatt tttagggtga 56340 gataaaaatg gaaacatcta gtttttagca tccacttgtg ctttttcttt agggtgataa 56400 aggacctcga ggagagaaag gagaaagagg agatgttggg attcgagggg acccggtaaa 56460 gatttcttta ttgacgattt cagacctgag cctggggaag agggttgttg ggaaaggggg 56520 atgaaaggaa gaattctact tttgaaattg ctttaaaaca cgttgataaa atatgtgctt 56580 tgtctttttc ttgcagtttg ggggtttggg gagatgtgtt ggttctcttg ctaaccagat 56640 aatcatttgc aagtcctgtt atacaaatat ctgagaagtt tccaaaaatg tggtatcagg 56700 gcacttcaaa tttgcttttg gaaaagagaa gagtttgcag cttttctcat tttgtgtctc 56760 tgtaaaacgt ttaagcaaat gagcagtaca agctagcctc ttcttccagt ccatcctgcc 56820 tctgtggcca aggataagca ggagtgagcc tggggcatcc tcctccctgg ggaagaacga 56880 ttgcacctgt ttggggctaa gagtgctttg ctgatcccgt gattgggttt cgtaagacct 56940 gcatggatgt tacctggatg ggttgtggcc gaagggcttg tccctcgaag ccttgcatgc 57000 aggtccttgc taatatttcc ctgaccatcc agtccagtgg cagctgcttt ccttccatat 57060 gtggctcatt tccctttccc atgttgcttt cagggtaacc caggacaaga cagccaggag 57120 agaggaccca aaggagaaac cggtgacctc ggccccatgg taaggtgctg cacattccta 57180 gactctccct gtactgaggg caagagaaag gacacacttc tcggctcatc agcagccaca 57240 gaggccaaag acgtggcctt taacactgca acgtagccta agattagcag cagagtcccc 57300 gtgaaggaag tctccgtggg gaaccagagt gacccttgcc aagtggggct tctcagcaga 57360 atctgtgcct cttagatatt tacggaaggt gcttgttaag ccaaaggctt gtagaggtgg 57420 gagtgtactg aagtccggtg catcctgcaa agtgtgcaac tgtcctgcag acgggctctt 57480 cctctgtgaa tcgacccctt tccctgcaat gtcttgtgca gcatttcaga gctagacatt 57540 cttctctgca gatgagaatc tcatgctaat tttccccaca ccagggtgtc ccagggagag 57600 atggagtacc tggaggacct ggagaaactg ggaagaatgt gagtgccatt agggctttgg 57660 ggggctctgt gacaattctt agtgccataa gatctgccca acatgacctg gtgcatggtt 57720 agtccacagc tctgcagtga gtgaatgtaa aaggatttct gaaacggttg ttactccaat 57780 Página 216

P201430887 ES 2 553 786 A1 09-06-2014 ctattttcat tcttataatt tccctggtgc ttcatctctt ctctctcccc aattcttgct 57840   ctccccaaaa acatactgaa cagatacttt taaaaataat atctttgcta ctttcaaata 57900 tcgggccagg tttgatccaa ctaaatattt aagagaccca aatggaaatc ctaatactgg 57960 gggagggagg gaataagggg caagagggct gagggagttg tggatttgtt gtttttgtaa 58020 ttatctgtgg gtttttgggg ggatgctgta agtgaaataa aaaaactaga tttcttcttt 58080 ttctggcgta ttgcatcttg caatttcaag acatttcaga aatgtctgta gcagaatagc 58140 tccttgtatg cctaatcctc agtcttgttg aataaatgct aaagtcaaag tgatgtgaat 58200 gatctttctg aagccaacca aaagcttcca aggtcctcgg gcacagacag catctgcctt 58260 gtagctggga gaagaccagt ggtgtagaag tttgtaacct ctcagaggaa attcaggatg 58320 ctggtgggtg cctaggggag gtctctgctc agaaatgaac agagcacaaa ggctgcaagc 58380 tggggctggg tgctgggaac tgggccctca gccacgccct gaggggcagt ggctcgttcg 58440 gcccggcact tgggccagta gagttcgctg gggtgagggg ctttcaaaag gagcgactca 58500 ccaaaatcaa attgatggac tatgggcatc attttgcttt gaaaattcag aagaaaatag 58560 aaattttgaa aatatcattt taaaatgttt gagcactatt tatttattta tttttaataa 58620 attgtaaaga cctggatcaa ctgcttggaa gtgagcatta tttttgaata atgctatata 58680 atgaaaaaga agctatataa tgaaaaagaa gaaatactca tcaaatgtta caatgggcta 58740 ttacaactca gcgtgtgagc agagccaaaa cttggtttca tgaaatgact taaaattgag 58800 tagttcatac aattaatttc aattctacac acaaggtaga aactggattt gaattcggtt 58860 tcagtcacgg gctcttgagg actcagttct tccttttgtg gtctaatggc ctgctatccc 58920 ttcccttagg accacagtgc caggctcagg ccaagctgaa atgtgtccct cccactgggc 58980 ttcagcatgc ctacatcccc tttctagagt ctccgcaggc ggcctctggc ctgagcaatg 59040 tatcactgag tgctgctgga ctctcatgga actctagcat gtctcttttg ggaggggcca 59100 ggccagattg ttggtttgta gaggagaaca gtgtcccctt gtctcaaatt ttccatggaa 59160 ggtggccaag atcttccgct gaagcaggtg gcattacagc gaataatggc aaactggtca 59220 ccgcagatca ctgggctggt ccattggaag tggagagtga ggttcctagg ttgatgtagc 59280 agatgactga gccccacaac agagctagtc ggtcacagcc tctgcaacac caaccctaac 59340 tttgcaaaga ccgcctggga cattcataaa gtcccacccc aaacctttct actgctgagg 59400 aaacaatttt gaggtggaaa ttaatggatt acttgtgaag taagcccaca tgtttgaact 59460 aaaggtcacc tctggagcat ccaggaagat gttgccaagt cgtgagccct acctaagtac 59520 acgagacgtt taggtgcaca tgtgtgtgct tcagatattt tacttaaccg agtgtgtgtt 59580 gtgtttggcc gggatcactt ggagaacctg ggactccctt ccattataat taatgtattt 59640 catgacttct cagtacagtt gggaaggtgg aagaaaaata gacaggttga cattcccttt 59700 tcacattcct catttgaaac tggctgggat cgtgcagcca aaaggagtca ttattttgct 59760 tggcaggtct gcagtaattc tcaaaacttc cattgggtga ttaacaggag cagcaaggaa 59820 gcaaaacttc acccggatga gggtggagga agggtgtctg tgtgtgcgag tttccccagg 59880 Página 217

P201430887 ES 2 553 786 A1 09-06-2014 gctgatgagg tgtggtttct ggttcttggc acgatgtggg tgcttgggaa gattcccctg 59940   agtaaccgca gaataagagg gtgaagtctg aaagagctct aggccccatg cccagcgtcc 60000 catgctcccc ctcacagttt gtgggacttt ttcttccaca gggtggcttt ggccgaaggg 60060 gaccccccgg agctaaggtg agcctcatgc agtgccccct ggagactctc ttcaaacagc 60120 ccagatgccg cccagcccag gagtgaaaaa cactctctcc tgtgaaccca aagcttcgga 60180 gacagatacc aatcaattta gaaagttgat ttcgccaagg ttaaagacat gcccgtgaca 60240 cagcctcaga aggccctgat gacacctgcc caaggtgttc ggggcacagc ttggttttac 60300 acattttagg gagacatgag acatcaatca atatgtgtga gatgtacatt ggttcggtcc 60360 agaaaggtgg gacaactcga ggcaggggag gaggcttcca ggtcataggt agataagaga 60420 caaaaggttg cattcttttg agtctctgat tagcctttca ctgaatacac agtttaccag 60480 aacagtcacc tatgccttag ttaggcttag tgaaaaacag ggcgaaggaa gcaattggat 60540 atgcctttgt ctcccatgag cagagggatg actttcagtt ctgtctgtcc tttgtccaca 60600 aggaatttcc ctgtgggcag aatgtgaggg aggtattcag cttaaaaaaa aaaaaatctg 60660 gccaggacgg tggctgatgc ctgtaatccc agcactctgg gaggctgaga caggcggatc 60720 acctgaggtt gggagttcga gactagcctg accaatatg